Aliases for CES1P1 Gene
Aliases for CES1P1 Gene
External Ids for CES1P1 Gene
- HGNC: 18546
- Entrez Gene: 51716
- Ensembl: ENSG00000228695
- UniProtKB: Q9UKY3
Previous HGNC Symbols for CES1P1 Gene
- CES4
Summaries for CES1P1 Gene
-
This gene is a member of the carboxylesterase (CES) gene family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene does not encode a protein and the sequence is similar to the CES1 gene, so represents a pseudogene of the CES1 gene. [provided by RefSeq, Jun 2010]
GeneCards Summary for CES1P1 Gene
CES1P1 (Carboxylesterase 1 Pseudogene 1) is a Pseudogene.
UniProtKB/Swiss-Prot for CES1P1 Gene
-
Has no esterase activity.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES1P1 Gene
Genomics for CES1P1 Gene
Regulatory Elements for CES1P1 Gene
Enhancers for CES1P1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH16G055752 | 1.1 | Ensembl ENCODE | 31.5 | -7.1 | -7051 | 2.7 | ELF3 FOXA2 CREB3L1 ARNT NFRKB TCF12 EGR1 FOS ETV6 MIXL1 | CES1P1 CES1 CES1P2 |
| GH16G055832 | 1.2 | Ensembl ENCODE | 13 | +72.5 | 72521 | 1.4 | FOXA2 ARID4B DMAP1 ZNF48 YY1 SLC30A9 SP5 ZHX2 MIER2 REST | CES1 CES1P1 CES1P2 |
| GH16G055773 | 0.5 | ENCODE | 14.1 | +13.7 | 13738 | 1.2 | NFIC NFIB TAF1 NRF1 ZNF24 | CES1P1 CES1 |
| GH16G055787 | 0.5 | FANTOM5 | 6.9 | +27.5 | 27530 | 0.3 | CEBPA CEBPG | CES1P1 CES1 |
| GH16G055757 | 0.5 | FANTOM5 | 0.7 | -3.4 | -3428 | 0.3 | HNF4A | CES1P1 CES1P2 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CES1P1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for CES1P1 Gene
- Chromosome:
- 16
- Start:
- 55,760,566 bp from pter
- End:
- 55,793,960 bp from pter
- Size:
- 33,395 bases
- Orientation:
- Plus strand
Genomic View for CES1P1 Gene
Genes around CES1P1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q12.2 by Ensembl
- 16q12.2 by Entrez Gene
- 16q12.2 by HGNC
CES1P1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CES1P1 Gene
Proteins for CES1P1 Gene
-
Protein details for CES1P1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UKY3-CES1P_HUMAN
- Recommended name:
- Putative inactive carboxylesterase 4
- Protein Accession:
- Q9UKY3
- A2RRL8
- B9ZVS2
Protein attributes for CES1P1 Gene
- Size:
- 287 amino acids
- Molecular mass:
- 30679 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAF14185.1; Type=Frameshift; Positions=92, 95; Evidence={ECO:0000305};
Protein Expression for CES1P1 Gene
Post-translational modifications for CES1P1 Gene
- Glycosylation at posLast=8080
Antibody Products
-
Abcam antibodies for CES1P1
- Invitrogen Antibodies for CES1P1
- Search GeneTex for Antibodies for CES1P1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CES1P1
- Origene Custom Protein Services for CES1P1
- Search GeneTex for Proteins for CES1P1
Assay Products
No data available for DME Specific Peptides for CES1P1 Gene
Domains & Families for CES1P1 Gene
Protein Domains for CES1P1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CES1P1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UKY3- Family:
-
- Belongs to the type-B carboxylesterase/lipase family.
No data available for Gene Families for CES1P1 Gene
Function for CES1P1 Gene
Molecular function for CES1P1 Gene
- UniProtKB/Swiss-Prot Function:
- Has no esterase activity.
Phenotypes for CES1P1 Gene
- GenomeRNAi human phenotypes for CES1P1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CES1P1
-
- Search ViGene Biosciences for CES1P1
CRISPR Products
- Browse CRISPR knockouts for CES1P1
miRNA Products
- Search ViGene Biosciences for CES1P1
Inhibitory RNA Products
- Origene RNAi and shRNA products in human, mouse, rat for CES1P1
- Browse OriGene Inhibitory RNA Products For CES1P1
- Search ViGene Biosciences for CES1P1
Clone Products
- GenScript: Custom all cDNA clones Services for CES1P1
- VectorBuilder custom plasmid, inducible vectors for CES1P1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CES1P1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
- Search ViGene Biosciences for CES1P1
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CES1P1 Gene
Localization for CES1P1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CES1P1 Gene
- Secreted.
No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CES1P1 Gene
Pathways & Interactions for CES1P1 Gene
No data available for Pathways by source and SIGNOR curated interactions for CES1P1 Gene
Drugs & Compounds for CES1P1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Capecitabine | Approved, Investigational | Pharma | RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines | 1342 | ||
| Clopidogrel | Approved | Nutra | P2Y12 receptor antagonist | 778 | ||
| 1,1,1-TRIFLUORO-3-(OCTYLTHIO)ACETONE | Experimental | Pharma | Target | 0 |
Transcripts for CES1P1 Gene
mRNA/cDNA for CES1P1 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (64) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CES1P1 Gene
CRISPR Products
- Browse CRISPR knockouts for CES1P1
miRNA Products
- Search ViGene Biosciences for CES1P1
Inhibitory RNA Products
- Origene RNAi and shRNA products in human, mouse, rat for CES1P1
- Browse OriGene Inhibitory RNA Products For CES1P1
- Search ViGene Biosciences for CES1P1
Clone Products
- GenScript: Custom all cDNA clones Services for CES1P1
- VectorBuilder custom plasmid, inducible vectors for CES1P1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CES1P1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CES1P1 Gene
mRNA differential expression in normal tissues according to GTEx for CES1P1 Gene
This gene is overexpressed in Liver (x25.4).
This gene is overexpressed in Nasal epithelium (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CES1P1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CES1P1 Gene:
CES1P1SOURCE GeneReport for Unigene cluster for CES1P1 Gene:
Hs.721645mRNA Expression by UniProt/SwissProt for CES1P1 Gene:
Q9UKY3-CES1P_HUMAN
Tissue specificity:
Expressed in placenta.
Primer Products
-
OriGene qPCR primer pairs for CES1P1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CES1P1 Gene
Orthologs for CES1P1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| zebrafish (Danio rerio) |
Actinopterygii | wufb66e04 34 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.159 34 |
|
- Species where no ortholog for CES1P1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CES1P1 Gene
(14) SIMAP similar genes for CES1P1 Gene using alignment to 1 proteins:
No data available for Paralogs for CES1P1 Gene
Variants for CES1P1 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1001039364 | -- | 55,766,912(+) | TCACT(A/G)CTCTC | intron-variant | |
| rs1006492236 | -- | 55,759,206(+) | GCTGG(C/G)TTCTT | upstream-variant-2KB | |
| rs1017932767 | -- | 55,759,213(+) | TCTTT(C/T)CTTTA | upstream-variant-2KB | |
| rs1025786380 | -- | 55,761,014(+) | GGCTC(C/G)ATAAC | intron-variant | |
| rs1052421913 | -- | 55,772,186(+) | TGCCA(G/T)TTGAG | intron-variant |
Relevant External Links for CES1P1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CES1P1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CES1P1 Gene
Disorders for CES1P1 Gene
Relevant External Links for CES1P1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CES1P1
No disorders were found for CES1P1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CES1P1 Gene
Publications for CES1P1 Gene
- Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms. (PMID: 10452915) Yan B. … Yang D. (Placenta 1999) 2 3 4 22 64
- Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. (PMID: 20931200) Holmes R.S. … Maltais L.J. (Mamm. Genome 2010) 2 3 64
- Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus. (PMID: 26871237) Sanford J.C. … Sadee W. (Pharmacogenet. Genomics 2016) 3 64
- The effects of CES1A2 A(-816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease. (PMID: 24535487) Xie C. … Miao L. (Pharmacogenet. Genomics 2014) 3 64
- Mutation-sensitive molecular switch method to detect CES1A2 mutation in the Chinese Han and Yao populations. (PMID: 21510813) Ding X.L. … Miao L.Y. (Genet Test Mol Biomarkers 2011) 3 64
Products for CES1P1 Gene
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for CES1P1
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- OriGene qPCR primer pairs for CES1P1
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Invitrogen Antibodies for CES1P1
- Cyagen custom Knockout/knockin (KOKI) mouse models for CES1P1
- VectorBuilder custom plasmid, inducible vectors for CES1P1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CES1P1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CES1P1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
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- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
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- (100) COMPARTMENTS
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- (109) TreeFam
- (110) PathCards
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- (155) Gene ORGANizer