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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CES1P1 Gene

pseudogene   GIFtS: 34
GCID: GC16P055795

Carboxylesterase 1 Pseudogene 1

(Previous names: carboxylesterase 4-like, carboxylesterase 4, pseudogene)
(Previous symbol: CES4)
  Search for CES1P1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carboxylesterase 1 Pseudogene 11 2     CES1A22
CES41 2 3     CES1A32
PCE-32 3     CESR2
Carboxylesterase 4, Pseudogene1     Inactive Carboxylesterase 1 Pseudogene 13
Carboxylesterase 4-Like1     Placental Carboxylesterase 33

External Ids:    HGNC: 185461   Entrez Gene: 517162   Ensembl: ENSG000002286957   UniProtKB: Q9UKY33   

Export aliases for CES1P1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CES1P1 Gene:
This gene is a member of the carboxylesterase (CES) gene family. The family members are responsible for the
hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates
with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and
may play a role in the blood-brain barrier system. This gene does not encode a protein and the sequence is
similar to the CES1 gene, so represents a pseudogene of the CES1 gene. (provided by RefSeq, Jun 2010)

GeneCards Summary for CES1P1 Gene: 
CES1P1 (carboxylesterase 1 pseudogene 1) is a pseudogene.

UniProtKB/Swiss-Prot: CES1P_HUMAN, Q9UKY3
Function: Has no esterase activity (Probable)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CES1P1
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CES1P1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

CES1P1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CES1P1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P055795:  view genomic region     (about GC identifiers)

Start:
55,794,460 bp from pter      End:
55,828,070 bp from pter
Size:
33,611 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: CES1P_HUMAN, Q9UKY3 (See protein sequence)
Recommended Name: Putative inactive carboxylesterase 4 precursor  
Size: 287 amino acids; 30679 Da
Subcellular location: Secreted (Potential)
Caution: In contrast to other members of the family, it is shorter and lacks the C-terminal part that contains the
conserved Glu and His active sites
Caution: Could be the product of a pseudogene
Sequence caution: Sequence=AAF14185.1; Type=Frameshift; Positions=92, 95;
Secondary accessions: A2RRL8 B9ZVS2
Alternative splicing: 2 isoforms:  Q9UKY3-1   Q9UKY3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CES1P1: NX_Q9UKY3

Explore proteomics data for CES1P1 at MOPED 

CES1P1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CES1P1 Protein Expression

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro protein domains:
 IPR019819 Carboxylesterase_B_CS
 IPR002018 CarbesteraseB

Graphical View of Domain Structure for InterPro Entry Q9UKY3

ProtoNet protein and cluster: Q9UKY3

UniProtKB/Swiss-Prot: CES1P_HUMAN, Q9UKY3
Similarity: Belongs to the type-B carboxylesterase/lipase family


CES1P1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CES1P_HUMAN, Q9UKY3
Function: Has no esterase activity (Probable)

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CES1P1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for CES1P1 (CES1P)

2 DrugBank Compounds for CES1P1    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
1,1,1-TRIFLUORO-3-(OCTYLTHIO)ACETONE-- --target--10592235
Alpha-D-Mannose-- 3458-28-4target--10592235

Search CenterWatch for drugs/clinical trials and news about CES1P1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for CES1P1 gene: 
NM_016280.1  

Unigene Cluster for CES1P1:

Carboxylesterase 1 pseudogene 1
Hs.721645  [show with all ESTs]
Unigene Representative Sequence: NR_003276
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000421606 ENST00000574030 ENST00000571348(uc002eik.3 uc010cce.3)
ENST00000573705 ENST00000427184
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Additional mRNA sequence: 

BC131699.1 NR_003276.2 

5 DOTS entries:

DT.455216  DT.100828223  DT.100828227  DT.92437972  DT.92437982 

24/64 AceView cDNA sequences (see all 64):

BU732288 AI129284 AW006490 AW138926 BU741184 T58736 BU630682 AA058807 
AI922776 BQ447758 CA428804 BE784641 AI670722 AI688105 AI685449 BM726902 
T61766 AW117807 AA043416 AA448222 BE047033 AI913176 CA415755 T58803 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CES1P1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTGGGCAGTG
CES1P1 Expression
About this image


See CES1P1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CES1P1

SOURCE GeneReport for Unigene cluster: Hs.721645

UniProtKB/Swiss-Prot: CES1P_HUMAN, Q9UKY3
Tissue specificity: Expressed in placenta

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES1P1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CES1P1 gene from 1/2 species (see all 2)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
zebrafish
(Danio rerio)
Actinopterygii wufb66e042 wufb66e04 74.39(n)   322588  CK144148.1 


ENSEMBL Gene Tree for CES1P1 (if available)
TreeFam Gene Tree for CES1P1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CES1P1 gene
14 SIMAP similar genes for CES1P1 using alignment to 1 protein entry:     CES1P_HUMAN:
CES1    CES hBr2    CES2    CES4A    NLGN2    CES3
CES5A    BCHE    NLGN3    ACHE    CEL    TG
NLGN1    nlgn1

CES1P1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/582 SNPs in CES1P1 are shown (see all 582)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1398632431,2
--55792547(+) TCTCAC/TGGGGT 1 -- us2k10--------
rs1444348411,2
--55792699(+) AGATTA/GCAGCC 1 -- us2k10--------
rs620271321,2
C--55792733(+) ATTAGA/CTATAT 1 -- us2k10--------
rs1893252291,2
--55792761(+) CCATGC/TAAATA 1 -- us2k10--------
rs344801031,2
C,F--55792784(+) ACTACT/CAAAAC 1 -- us2k16Minor allele frequency- C:0.18NA WA CSA 11
rs611908801,2
C--55792790(+) AAAACA/GGGACC 1 -- us2k10--------
rs341084511,2
C,F--55792816(+) AGATTC/TTCAAA 1 -- us2k15Minor allele frequency- T:0.20NA 10
rs1818780511,2
--55792942(+) TTAATC/GCCAGG 1 -- us2k10--------
rs1854214881,2
--55792979(+) CTCATG/TCCCAT 1 -- us2k10--------
rs118649981,2
C,A,H--55792992(+) GCAGTT/CATTCC 1 -- us2k13Minor allele frequency- C:0.20NA WA 122

HapMap Linkage Disequilibrium report for CES1P1 (55794460 - 55828070 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/24 variations for CES1P1 (see all 24):    About this table     
Variant IDTypeSubtypePubMed ID
esv2421900CNV Deletion20811451
esv2714505CNV Deletion23290073
dgv496e199CNV Deletion23128226
nsv819089CNV Loss19587683
esv1000115CNV Loss20482838
esv21956CNV Loss19812545
nsv827667CNV Loss20364138
nsv906673CNV Loss21882294
dgv477n67CNV Loss20364138
nsv9445CNV Loss18304495

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CES1P1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CES1P1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms. (PubMed id 10452915)1, 2, 3, 9 Yan B.... Yang D. (1999)
  2. Recommended nomenclature for five mammalian carboxyle sterase gene families: human, mouse, and rat genes and proteins. (PubMed id 20931200)1, 3 Holmes R.S....Maltais L.J. (2010)
  3. Mutation-sensitive molecular switch method to detect C ES1A2 mutation in the Chinese Han and Yao populations. (PubMed id 21510813)1 Ding X.L....Miao L.Y. (2011)
  4. Genetic variation in carboxylesterase genes and susce ptibility to isoniazid-induced hepatotoxicity. (PubMed id 20195289)1 Yamada S....Brooks-Wilson A. (2010)
  5. Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes. (PubMed id 18794728)1 Fukami T....Yokoi T. (2008)
  6. Human carboxylesterase 1A2 expressed from carboxylest erase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro. (PubMed id 17264798)1 Tanimoto K....Nishiyama M. (2007)
  7. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 51716 HGNC: 18546 AceView: CES4 Ensembl:ENSG00000228695 euGenes: HUgn51716
ECgene: CES1P1 H-InvDB: CES1P1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CES1P1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CES1P1 gene:
Search GeneIP for patents involving CES1P1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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