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Aliases for CES1P1 Gene

Aliases for CES1P1 Gene

  • Carboxylesterase 1 Pseudogene 1 2 3
  • Carboxylesterase 4, Pseudogene 2 3
  • PCE-3 3 4
  • CES4 3 4
  • Inactive Carboxylesterase 1 Pseudogene 1 4
  • Carboxylesterase-Related Protein 3
  • Placental Carboxylesterase 3 4
  • Carboxylesterase 4-Like 2
  • CES1A2 3
  • CES1A3 3
  • CESR 3

External Ids for CES1P1 Gene

Previous HGNC Symbols for CES1P1 Gene

  • CES4

Summaries for CES1P1 Gene

Entrez Gene Summary for CES1P1 Gene

  • This gene is a member of the carboxylesterase (CES) gene family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene does not encode a protein and the sequence is similar to the CES1 gene, so represents a pseudogene of the CES1 gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for CES1P1 Gene

CES1P1 (Carboxylesterase 1 Pseudogene 1) is a Pseudogene.

UniProtKB/Swiss-Prot for CES1P1 Gene

  • Has no esterase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES1P1 Gene

Genomics for CES1P1 Gene

Genomic Location for CES1P1 Gene

55,760,548 bp from pter
55,794,158 bp from pter
33,611 bases
Plus strand

Genomic View for CES1P1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CES1P1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES1P1 Gene

No data available for Regulatory Elements for CES1P1 Gene

Proteins for CES1P1 Gene

  • Protein details for CES1P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative inactive carboxylesterase 4
    Protein Accession:
    Secondary Accessions:
    • A2RRL8
    • B9ZVS2

    Protein attributes for CES1P1 Gene

    287 amino acids
    Molecular mass:
    30679 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF14185.1; Type=Frameshift; Positions=92, 95; Evidence={ECO:0000305};

    Alternative splice isoforms for CES1P1 Gene


neXtProt entry for CES1P1 Gene

Proteomics data for CES1P1 Gene at MOPED

Post-translational modifications for CES1P1 Gene

No data available for DME Specific Peptides for CES1P1 Gene

Domains & Families for CES1P1 Gene

Protein Domains for CES1P1 Gene

Suggested Antigen Peptide Sequences for CES1P1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type-B carboxylesterase/lipase family.
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES1P1: view

No data available for Gene Families for CES1P1 Gene

Function for CES1P1 Gene

Molecular function for CES1P1 Gene

UniProtKB/Swiss-Prot Function:
Has no esterase activity.

Phenotypes for CES1P1 Gene

GenomeRNAi human phenotypes for CES1P1:
genes like me logo Genes that share phenotypes with CES1P1: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CES1P1 Gene

Localization for CES1P1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES1P1 Gene


No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CES1P1 Gene

Pathways & Interactions for CES1P1 Gene

SuperPathways for CES1P1 Gene

No Data Available

Interacting Proteins for CES1P1 Gene

Gene Ontology (GO) - Biological Process for CES1P1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CES1P1 Gene

Drugs & Compounds for CES1P1 Gene

(2) Drugs for CES1P1 Gene - From: PharmGKB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clopidogrel Approved Nutra P2Y12 receptor antagonist 674
1,1,1-TRIFLUORO-3-(OCTYLTHIO)ACETONE Experimental Pharma Target 0
genes like me logo Genes that share compounds with CES1P1: view

Transcripts for CES1P1 Gene

mRNA/cDNA for CES1P1 Gene

Unigene Clusters for CES1P1 Gene

Carboxylesterase 1 pseudogene 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CES1P1 Gene

No ASD Table

Relevant External Links for CES1P1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CES1P1 Gene

mRNA expression in normal human tissues for CES1P1 Gene

mRNA differential expression in normal tissues according to GTEx for CES1P1 Gene

This gene is overexpressed in Liver (x25.4).

Protein differential expression in normal tissues from HIPED for CES1P1 Gene

This gene is overexpressed in Nasal epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CES1P1 Gene

SOURCE GeneReport for Unigene cluster for CES1P1 Gene Hs.721645

mRNA Expression by UniProt/SwissProt for CES1P1 Gene

Tissue specificity: Expressed in placenta.
genes like me logo Genes that share expression patterns with CES1P1: view

Protein tissue co-expression partners for CES1P1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CES1P1 Gene

Orthologs for CES1P1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CES1P1 Gene

Organism Taxonomy Gene Similarity Type Details
(Danio rerio)
Actinopterygii wufb66e04 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.159 35
Species with no ortholog for CES1P1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CES1P1 Gene

Gene Tree for CES1P1 (if available)
Gene Tree for CES1P1 (if available)

Paralogs for CES1P1 Gene

(14) SIMAP similar genes for CES1P1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CES1P1: view

No data available for Paralogs for CES1P1 Gene

Variants for CES1P1 Gene

Sequence variations from dbSNP and Humsavar for CES1P1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1974708 -- 55,759,925(+) ATGGG(C/T)ACATG upstream-variant-2KB
rs1974709 -- 55,760,172(+) AGCTG(A/C)GATAT upstream-variant-2KB
rs1985588 -- 55,767,691(+) TGACA(C/T)AGGGA intron-variant
rs1985589 -- 55,767,743(+) TTGTT(C/G)CAAGT intron-variant
rs1985590 -- 55,767,752(+) GTTCC(C/T)TCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CES1P1 Gene

Variant ID Type Subtype PubMed ID
nsv906673 CNV Loss 21882294
dgv892e1 CNV Complex 17122850
nsv906674 CNV Gain 21882294
nsv7284 OTHER Inversion 18451855
esv2714505 CNV Deletion 23290073
esv9707 OTHER Inversion 19470904
nsv147 OTHER Inversion 15895083
dgv2862n71 CNV Gain 21882294
dgv54e19 OTHER Inversion 19470904
esv998750 OTHER Inversion 20482838
esv2421900 CNV Deletion 20811451
nsv9445 CNV Loss 18304495
dgv477n67 CNV Loss 20364138
dgv496e199 CNV Deletion 23128226
esv32885 CNV Gain+Loss 17666407
nsv511560 CNV Gain 21212237
nsv499134 OTHER Inversion 21111241
esv21956 CNV Loss 19812545
esv1000115 CNV Loss 20482838
nsv442723 CNV CNV 18776908
nsv819089 CNV Loss 19587683
dgv15e197 OTHER Inversion 19546169
esv1010290 OTHER Inversion 20482838
nsv827667 CNV Loss 20364138

Relevant External Links for CES1P1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CES1P1 Gene

Disorders for CES1P1 Gene

Relevant External Links for CES1P1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CES1P1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CES1P1 Gene

Publications for CES1P1 Gene

  1. Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms. (PMID: 10452915) Yan B. … Yang D. (Placenta 1999) 2 23 67
  2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. (PMID: 20931200) Holmes R.S. … Maltais L.J. (Mamm. Genome 2010) 2 67
  3. The effects of CES1A2 A(-816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease. (PMID: 24535487) Xie C. … Miao L. (Pharmacogenet. Genomics 2014) 67
  4. Mutation-sensitive molecular switch method to detect CES1A2 mutation in the Chinese Han and Yao populations. (PMID: 21510813) Ding X.L. … Miao L.Y. (Genet Test Mol Biomarkers 2011) 67
  5. Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity. (PMID: 20195289) Yamada S. … Brooks-Wilson A. (Pharmacogenomics J. 2010) 67

Products for CES1P1 Gene

Sources for CES1P1 Gene

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