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Aliases for CES1P1 Gene

Aliases for CES1P1 Gene

  • Carboxylesterase 1 Pseudogene 1 2 3 5
  • Carboxylesterase 4, Pseudogene 2 3
  • PCE-3 3 4
  • CES4 3 4
  • Inactive Carboxylesterase 1 Pseudogene 1 4
  • Carboxylesterase-Related Protein 3
  • Placental Carboxylesterase 3 4
  • Carboxylesterase 4-Like 2
  • CES1A2 3
  • CES1A3 3
  • CESR 3

External Ids for CES1P1 Gene

Previous HGNC Symbols for CES1P1 Gene

  • CES4

Summaries for CES1P1 Gene

Entrez Gene Summary for CES1P1 Gene

  • This gene is a member of the carboxylesterase (CES) gene family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene does not encode a protein and the sequence is similar to the CES1 gene, so represents a pseudogene of the CES1 gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for CES1P1 Gene

CES1P1 (Carboxylesterase 1 Pseudogene 1) is a Pseudogene.

UniProtKB/Swiss-Prot for CES1P1 Gene

  • Has no esterase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES1P1 Gene

Genomics for CES1P1 Gene

Regulatory Elements for CES1P1 Gene

Enhancers for CES1P1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F055752 1.1 Ensembl ENCODE 31.5 -7.0 -7033 2.7 ELF3 ARNT CREB3L1 ETV1 BACH1 CEBPG ZNF316 NCOR1 NFE2 TRIM24 CES1P1 CES1 CES1P2
GH16F055832 1 ENCODE 13 +72.6 72551 1.3 ARID4B DMAP1 ZNF48 YY1 SLC30A9 SP5 ZHX2 MIER2 REST PPARG CES1 CES1P1 CES1P2
GH16F055773 0.7 Ensembl ENCODE 14 +13.8 13756 1.2 TAF1 NRF1 CES1P1 CES1
GH16F055782 0.6 Ensembl 9.1 +22.2 22153 0.6 ZFHX2 GLIS1 PRDM10 ZIC2 ATF2 EGR2 CES1P1 CES1
GH16F055787 0.4 FANTOM5 6.9 +27.5 27548 0.3 CEBPA CES1P1 CES1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CES1P1 on UCSC Golden Path with GeneCards custom track

Promoters for CES1P1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CES1P1 Gene

55,760,548 bp from pter
55,794,158 bp from pter
33,611 bases
Plus strand

Genomic View for CES1P1 Gene

Genes around CES1P1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CES1P1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CES1P1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES1P1 Gene

Proteins for CES1P1 Gene

  • Protein details for CES1P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative inactive carboxylesterase 4
    Protein Accession:
    Secondary Accessions:
    • A2RRL8
    • B9ZVS2

    Protein attributes for CES1P1 Gene

    287 amino acids
    Molecular mass:
    30679 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF14185.1; Type=Frameshift; Positions=92, 95; Evidence={ECO:0000305};

    Alternative splice isoforms for CES1P1 Gene


neXtProt entry for CES1P1 Gene

Post-translational modifications for CES1P1 Gene

No data available for DME Specific Peptides for CES1P1 Gene

Domains & Families for CES1P1 Gene

Protein Domains for CES1P1 Gene

Suggested Antigen Peptide Sequences for CES1P1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type-B carboxylesterase/lipase family.
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES1P1: view

No data available for Gene Families for CES1P1 Gene

Function for CES1P1 Gene

Molecular function for CES1P1 Gene

UniProtKB/Swiss-Prot Function:
Has no esterase activity.

Phenotypes for CES1P1 Gene

GenomeRNAi human phenotypes for CES1P1:
genes like me logo Genes that share phenotypes with CES1P1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CES1P1 Gene

Localization for CES1P1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES1P1 Gene


No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CES1P1 Gene

Pathways & Interactions for CES1P1 Gene

SuperPathways for CES1P1 Gene

No Data Available

Interacting Proteins for CES1P1 Gene

Selected Interacting proteins: Q9UKY3-CES1P_HUMAN for CES1P1 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CES1P1 Gene


No data available for Pathways by source and SIGNOR curated interactions for CES1P1 Gene

Drugs & Compounds for CES1P1 Gene

(2) Drugs for CES1P1 Gene - From: DrugBank and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clopidogrel Approved Nutra P2Y12 receptor antagonist 756
1,1,1-TRIFLUORO-3-(OCTYLTHIO)ACETONE Experimental Pharma Target 0
genes like me logo Genes that share compounds with CES1P1: view

Transcripts for CES1P1 Gene

mRNA/cDNA for CES1P1 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(64) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CES1P1 Gene

Carboxylesterase 1 pseudogene 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CES1P1 Gene

No ASD Table

Relevant External Links for CES1P1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CES1P1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CES1P1 Gene

mRNA differential expression in normal tissues according to GTEx for CES1P1 Gene

This gene is overexpressed in Liver (x25.4).

Protein differential expression in normal tissues from HIPED for CES1P1 Gene

This gene is overexpressed in Nasal epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CES1P1 Gene

Protein tissue co-expression partners for CES1P1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CES1P1 Gene:


SOURCE GeneReport for Unigene cluster for CES1P1 Gene:


mRNA Expression by UniProt/SwissProt for CES1P1 Gene:

Tissue specificity: Expressed in placenta.
genes like me logo Genes that share expression patterns with CES1P1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CES1P1 Gene

Orthologs for CES1P1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CES1P1 Gene

Organism Taxonomy Gene Similarity Type Details
(Danio rerio)
Actinopterygii wufb66e04 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.159 34
Species where no ortholog for CES1P1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CES1P1 Gene

Gene Tree for CES1P1 (if available)
Gene Tree for CES1P1 (if available)

Paralogs for CES1P1 Gene

(14) SIMAP similar genes for CES1P1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CES1P1: view

No data available for Paralogs for CES1P1 Gene

Variants for CES1P1 Gene

Sequence variations from dbSNP and Humsavar for CES1P1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111314076 -- 55,773,402(+) CTGTC(A/T)GGTTT splice-acceptor-variant, utr-variant-5-prime
rs111382289 -- 55,760,894(+) AACAT(A/C/G/T)CTGAG intron-variant
rs111465073 -- 55,774,818(+) TGCCT(A/G)TAATC nc-transcript-variant
rs111515446 -- 55,764,366(+) GCATG(C/T)GGCTC intron-variant
rs111917669 -- 55,759,557(+) AATAA(A/G)TAGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CES1P1 Gene

Variant ID Type Subtype PubMed ID
nsv977980 CNV duplication 23825009
nsv9445 CNV loss 18304495
nsv827667 CNV loss 20364138
nsv819089 CNV loss 19587683
nsv7284 OTHER inversion 18451855
nsv572636 CNV gain+loss 21841781
nsv572635 CNV loss 21841781
nsv572632 CNV gain 21841781
nsv511560 CNV gain 21212237
nsv499134 OTHER inversion 21111241
nsv442723 CNV loss 18776908
nsv147 OTHER inversion 15895083
nsv1118354 CNV deletion 24896259
nsv1069947 CNV deletion 25765185
nsv1065976 CNV gain+loss 25217958
nsv1061487 CNV gain 25217958
nsv1061214 CNV gain 25217958
nsv1056715 CNV loss 25217958
esv998750 OTHER inversion 20482838
esv9707 OTHER inversion 19470904
esv3638687 CNV gain 21293372
esv3638686 CNV loss 21293372
esv3638685 CNV loss 21293372
esv3584713 CNV loss 24956385
esv3582227 CNV loss 25503493
esv3571320 CNV gain 25503493
esv3571298 CNV gain 25503493
esv32885 CNV gain+loss 17666407
esv2936012 CNV deletion 24192839
esv2758649 CNV gain 17122850
esv2714505 CNV deletion 23290073
esv2421900 CNV deletion 20811451
esv21956 CNV loss 19812545
esv1010290 OTHER inversion 20482838
esv1000115 CNV loss 20482838
dgv839e212 CNV loss 25503493
dgv838e212 CNV loss 25503493
dgv837e212 CNV gain 25503493
dgv836e212 CNV gain 25503493
dgv835e212 CNV loss 25503493
dgv834e212 CNV gain 25503493
dgv833e212 CNV gain 25503493
dgv832e212 CNV loss 25503493
dgv831e212 CNV loss 25503493
dgv62e19 OTHER inversion 19470904
dgv52e203 CNV gain+loss 21179565
dgv5132n54 CNV loss 21841781
dgv5131n54 CNV loss 21841781
dgv5130n54 CNV loss 21841781
dgv5129n54 CNV loss 21841781
dgv5128n54 CNV gain+loss 21841781
dgv5127n54 CNV loss 21841781
dgv5126n54 CNV loss 21841781
dgv496e199 CNV deletion 23128226
dgv477n67 CNV loss 20364138
dgv2986n100 CNV gain+loss 25217958
dgv2985n100 CNV loss 25217958
dgv24e213 CNV gain 24956385
dgv15e197 OTHER inversion 19546169
dgv122n111 CNV deletion 26073780

Relevant External Links for CES1P1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CES1P1 Gene

Disorders for CES1P1 Gene

Relevant External Links for CES1P1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CES1P1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CES1P1 Gene

Publications for CES1P1 Gene

  1. Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms. (PMID: 10452915) Yan B. … Yang D. (Placenta 1999) 2 3 4 22 64
  2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. (PMID: 20931200) Holmes R.S. … Maltais L.J. (Mamm. Genome 2010) 2 3 64
  3. Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus. (PMID: 26871237) Sanford J.C. … Sadee W. (Pharmacogenet. Genomics 2016) 3 64
  4. The effects of CES1A2 A(-816)C and CYP2C19 loss-of-function polymorphisms on clopidogrel response variability among Chinese patients with coronary heart disease. (PMID: 24535487) Xie C. … Miao L. (Pharmacogenet. Genomics 2014) 3 64
  5. Mutation-sensitive molecular switch method to detect CES1A2 mutation in the Chinese Han and Yao populations. (PMID: 21510813) Ding X.L. … Miao L.Y. (Genet Test Mol Biomarkers 2011) 3 64

Products for CES1P1 Gene

Sources for CES1P1 Gene

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