CES1P1 Gene
pseudogene GIFtS: 33
GCID: GC16P055795
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carboxylesterase 1 pseudogene 1(Previous names: carboxylesterase 4-like, carboxylesterase 4, pseudogene...)
(Previous symbol: CES4)
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Aliases
for CES1P1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Carboxylesterase 1 Pseudogene 11 2 | | Carboxylesterase 4, Pseudogene1 | | CES41 2 3 | | Carboxylesterase 4-Like1 | | PCE-31 2 3 | | CES1A22 | | CES1A31 2 | | Inactive Carboxylesterase 1 Pseudogene 13 | | CESR1 2 | | Placental Carboxylesterase 33 |
Export aliases for CES1P1 gene to outside databases |
Summaries
for CES1P1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CES1P1:
This gene is a member of the carboxylesterase (CES) gene family. The family members are responsible for the hydrolysisor transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester,thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role inthe blood-brain barrier system. This gene does not encode a protein and the sequence is similar to the CES1 gene, sorepresents a pseudogene of the CES1 gene. (provided by RefSeq, Jun 2010)
UniProtKB/Swiss-Prot: CES1P_HUMAN, Q9UKY3Function: Has no esterase activity (Probable)
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Genomic Views
for CES1P1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CES1P1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CES1P1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CES1P1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q12.2 Ensembl cytogenetic band: 16q12.2 HGNC cytogenetic band: 16q13CES1P1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P055795: view genomic region
(about GC identifiers)
Start:
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55,794,460 bp from pter |
End:
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55,828,070 bp from pter |
Size:
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33,611 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr16+,PATCHES 55,822,835-55,823,321 |
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Proteins
for CES1P1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: CES1P_HUMAN, Q9UKY3 (See
protein sequence)Recommended Name: Putative inactive carboxylesterase 4 precursor Size: 287 amino acids; 30679 Da
Subcellular location: Secreted (Potential)
Caution: In contrast to other members of the family, it is shorter and lacks the C-terminal part that contains theconserved Glu and His active sites
Caution: Could be the product of a pseudogene
Sequence caution: Sequence=AAF14185.1; Type=Frameshift; Positions=92, 95;
Secondary accessions: A2RRL8 B9ZVS2Alternative splicing: 2 isoforms: Q9UKY3-1 Q9UKY3-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CES1P1: NX_Q9UKY3
CES1P1 Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products:
CES1P1 Antibody Products:
Assay Products for CES1P1: |
Protein
Domains /
Families
for CES1P1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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CES1P1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UKY3ProtoNet protein and cluster: Q9UKY3 UniProtKB/Swiss-Prot: CES1P_HUMAN, Q9UKY3Similarity: Belongs to the type-B carboxylesterase/lipase family |
Function
for CES1P1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/Swiss-Prot: CES1P_HUMAN, Q9UKY3Function: Has no esterase activity (Probable)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES1P1 |
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Pathways & Interactions
for CES1P1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CES1P1
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Drugs & Compounds
for CES1P1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CES1P1
2 DrugBank Compounds for CES1P1 About this table
Search CenterWatch for drugs/clinical trials and news about CES1P1 
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Transcripts
for CES1P1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for CES1P1 gene: NM_016280.1 Unigene Cluster for CES1P1: Carboxylesterase 1 pseudogene 1 Hs.721645 [show with all ESTs]Unigene Representative Sequence: NR_0032765 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000421606 ENST00000574030 ENST00000571348(uc002eik.3 uc010cce.3)
ENST00000573705 ENST00000427184
Additional cDNA sequence: BC131699.1 NR_003276.2 5 DOTS entries: DT.455216 DT.100828223 DT.100828227 DT.92437972 DT.92437982 24/64 AceView cDNA sequences (see all 64): AI129284 T58736 AW006490 BU741184 AW138926 BU732288 AA448222 AA043416 AI922776 BU630682 AI688105 AI670722 AI685449 AI913176 AW117807 BE784641 BQ447758 AA058807 BE047033 CA428804 T61766 BM726902 CA415755 T58803
GeneLoc Exon Structure
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Expression
for CES1P1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CES1P1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGGGCAGTG
About this image
See CES1P1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CES1P1
SOURCE GeneReport for Unigene cluster: Hs.721645
UniProtKB/Swiss-Prot: CES1P_HUMAN, Q9UKY3Tissue specificity: Expressed in placenta
SABiosciences Custom PCR Arrays for CES1P1
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CES1P1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CES1P1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CES1P1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CES1P1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES1P1 |
Orthologs
for CES1P1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for CES1P1 gene from 1/2 species (see all 2) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb66e042 |
wufb66e04 |
74.39(n) |
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322588 CK144148.1 |
Species with no ortholog for CES1P1
ENSEMBL Gene Tree for CES1P1 (if available)
TreeFam Gene Tree for CES1P1 (if available) |
Paralogs
for CES1P1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CES1P1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for CES1P1 (55794460 - 55828070 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CES1P1: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for CES1P1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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CES1P1 for disorders About GeneDecksing
1  disease for CES1P1: About MalaCardscholesterol
Export disorders for CES1P1 gene to outside databases
|
Publications
for CES1P1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CES1P1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CES1P1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human carboxylesterases in term placentae: enzymatic characterization, molecular cloning and evidence for the existence of multiple forms. (PubMed id 10452915)1, 2, 3, 9 Yan B.... Yang D. (1999)
- Recommended nomenclature for five mammalian carboxyle sterase gene families: human, mouse, and rat genes and proteins. (PubMed id 20931200)1, 3 Holmes R.S....Maltais L.J. (2010)
- Genetic variation in carboxylesterase genes and susce ptibility to isoniazid-induced hepatotoxicity. (PubMed id 20195289)1 Yamada S....Brooks-Wilson A. (2010)
- Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes. (PubMed id 18794728)1 Fukami T....Yokoi T. (2008)
- Human carboxylesterase 1A2 expressed from carboxylest erase 1A1 and 1A2 genes is a potent predictor of CPT-11 cytotoxicity in vitro. (PubMed id 17264798)1 Tanimoto K....Nishiyama M. (2007)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)
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External Searches for CES1P1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CES1P1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing CES1P1 gene
(According to HUGE)
About This Section
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Specialized Databases showing CES1P1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CES1P1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CES1P1 gene:
Search GeneIP for patents involving CES1P1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CES1P1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CES1P1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CES1P1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CES1P1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CES1P1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CES1P1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CES1P1 |
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| | | | Search Tocris compounds for CES1P1 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES1P1 |
|  |  |  | | | | ThermoFisher Antibodies for CES1P1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CES1P1 |
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