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Aliases for CES1 Gene

Aliases for CES1 Gene

  • Carboxylesterase 1 2 3 4
  • SES1 3 4 6
  • Carboxylesterase 1 (Monocyte/Macrophage Serine Esterase 1) 2 3
  • Human Monocyte/Macrophage Serine Esterase 1 2 3
  • Acyl-Coenzyme A:Cholesterol Acyltransferase 3 4
  • Methylumbelliferyl-Acetate Deacetylase 1 3 4
  • Monocyte/Macrophage Serine Esterase 3 4
  • Brain Carboxylesterase HBr1 3 4
  • Triacylglycerol Hydrolase 3 4
  • Cocaine Carboxylesterase 3 4
  • Retinyl Ester Hydrolase 3 4
  • Serine Esterase 1 3 4
  • EC 3.1.1.1 4 63
  • Egasyn 3 4
  • HCE-1 3 4
  • ACAT 3 4
  • CE-1 3 4
  • CES2 3 4
  • HMSE 3 4
  • REH 3 4
  • TGH 3 4
  • Acyl Coenzyme A:Cholesterol Acyltransferase 3
  • Cholesteryl Ester Hydrolase 3
  • Carboxylesterase 2 (Liver) 3
  • Liver Carboxylesterase 1 3
  • EC 3.1.1.56 4
  • EC 3.1.1 63
  • HMSE1 3
  • PCE-1 3
  • CEH 3

External Ids for CES1 Gene

Previous GeneCards Identifiers for CES1 Gene

  • GC16M046044
  • GC16P055849
  • GC16P055518
  • GC16M055613
  • GC16M055615
  • GC16M054395
  • GC06P023997

Summaries for CES1 Gene

Entrez Gene Summary for CES1 Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for CES1 Gene

CES1 (Carboxylesterase 1) is a Protein Coding gene. Diseases associated with CES1 include reye syndrome. Among its related pathways are Metabolism and the visual cycle I (vertebrates). GO annotations related to this gene include methylumbelliferyl-acetate deacetylase activity. An important paralog of this gene is CES2.

UniProtKB/Swiss-Prot for CES1 Gene

  • Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.

Gene Wiki entry for CES1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES1 Gene

Genomics for CES1 Gene

Regulatory Elements for CES1 Gene

Transcription factor binding sites by QIAGEN in the CES1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CES1 Gene

Start:
55,802,851 bp from pter
End:
55,833,337 bp from pter
Size:
30,487 bases
Orientation:
Minus strand

Genomic View for CES1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CES1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES1 Gene

Proteins for CES1 Gene

  • Protein details for CES1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23141-EST1_HUMAN
    Recommended name:
    Liver carboxylesterase 1
    Protein Accession:
    P23141
    Secondary Accessions:
    • A6NIM1
    • A8K3K8
    • A8K844
    • E9PAU8
    • P82127
    • Q00015
    • Q13657
    • Q14062
    • Q16737
    • Q16788
    • Q549X7
    • Q549X8
    • Q86UK2
    • Q96EE8
    • Q9UC52
    • Q9UDG8
    • Q9UK77
    • Q9ULY2

    Protein attributes for CES1 Gene

    Size:
    567 amino acids
    Molecular mass:
    62521 Da
    Quaternary structure:
    • Homotrimer and homohexamer. Binds to beta-glucuronidase.
    SequenceCaution:
    • Sequence=AAA83932.1; Type=Frameshift; Positions=301, 312, 318, 383, 391; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CES1 Gene

    Alternative splice isoforms for CES1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CES1 Gene

Proteomics data for CES1 Gene at MOPED

Post-translational modifications for CES1 Gene

  • Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19
  • Contains sialic acid
  • Glycosylation at Asn79
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CES1 (Carboxylesterase 1/CES1)

Domains for CES1 Gene

Gene Families for CES1 Gene

HGNC:
  • CES :Carboxylesterases

Protein Domains for CES1 Gene

Suggested Antigen Peptide Sequences for CES1 Gene

Graphical View of Domain Structure for InterPro Entry

P23141

UniProtKB/Swiss-Prot:

EST1_HUMAN :
  • P23141
Family:
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES1: view

Function for CES1 Gene

Molecular function for CES1 Gene

GENATLAS Biochemistry:
carboxylesterase 1,expressed in brain,located in the endoplasmic reticulum,catalyzing the hydrolysis of temocapril,p-nitrophenyl-acetate and long chain acyl-CoA,putatively functioning as a blood-brain barrier to protect the CNS from ester or amide compounds
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=106.6 uM for p-nitrophenyl acetate {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; KM=775.7 uM for L-methylphenidate {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; KM=663.5 uM for D-methylphenidate {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; KM=116 uM for cocaine {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; KM=43 mM for ethanol {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; KM=0.8 mM for 4-methylumbelliferyl acetate {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; KM=6.3 mM for heroin {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; KM=8.3 mM for 6-monoacetylmorphine {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; Vmax=493.9 nmol/min/mg enzyme with p-nitrophenyl acetate as substrate {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; Vmax=1701.1 pmol/min/mg enzyme with L-methylphenidate as substrate {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; Vmax=177.2 pmol/min/mg enzyme with D-methylphenidate as substrate {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; pH dependence: Optimum pH is 6.5. {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062};
UniProtKB/Swiss-Prot CatalyticActivity:
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity:
4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by CHAPS.
UniProtKB/Swiss-Prot Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.

Enzyme Numbers (IUBMB) for CES1 Gene

Gene Ontology (GO) - Molecular Function for CES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity --
GO:0047374 methylumbelliferyl-acetate deacetylase activity IEA --
GO:0052689 carboxylic ester hydrolase activity TAS 8218228
genes like me logo Genes that share ontologies with CES1: view

Phenotypes for CES1 Gene

GenomeRNAi human phenotypes for CES1:
genes like me logo Genes that share phenotypes with CES1: view

Animal Model Products

miRNA for CES1 Gene

miRTarBase miRNAs that target CES1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CES1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CES1 Gene

Localization for CES1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES1 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CES1 Gene COMPARTMENTS Subcellular localization image for CES1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
cytosol 2
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005783 endoplasmic reticulum --
GO:0005788 endoplasmic reticulum lumen IEA --
genes like me logo Genes that share ontologies with CES1: view

Pathways for CES1 Gene

genes like me logo Genes that share pathways with CES1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
    • Drug Metabolism in human,mouse,rat

Interacting Proteins for CES1 Gene

Gene Ontology (GO) - Biological Process for CES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process TAS 1918003
GO:0009636 response to toxic substance TAS 1918003
GO:0030855 epithelial cell differentiation IDA 21492153
genes like me logo Genes that share ontologies with CES1: view

Compounds for CES1 Gene

(334) HMDB Compounds for CES1 Gene

Compound Synonyms Cas Number PubMed IDs
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Benzoic acid
  • Benzenecarboxylate
65-85-0
Carbon dioxide
  • Carbon oxide
124-38-9
CE(10:0)
  • Decanoic acid cholesteryl ester
1183-04-6

(28) Drugbank Compounds for CES1 Gene

(84) Novoseek inferred chemical compound relationships for CES1 Gene

Compound -log(P) Hits PubMed IDs
cl 277082 88.2 3
4-methylumbelliferyl acetate 83.9 3
avasimibe 83.8 9
3-(decyldimethylsilyl)-n-(2-(4-methylphenyl)-1-phenylethyl)propanamide 83.1 2
2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)dodecanamide 82.1 4

(4) PharmGKB related drug/compound annotations for CES1 Gene

Drug/compound Annotation
clopidogrel CA
Dabigatran CA
methylphenidate CA
sofosbuvir
genes like me logo Genes that share compounds with CES1: view

Transcripts for CES1 Gene

Unigene Clusters for CES1 Gene

Carboxylesterase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CES1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CES1 Gene

No ASD Table

Relevant External Links for CES1 Gene

GeneLoc Exon Structure for
CES1
ECgene alternative splicing isoforms for
CES1

Expression for CES1 Gene

mRNA expression in normal human tissues for CES1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CES1 Gene

This gene is overexpressed in Liver (23.9).

Protein differential expression in normal tissues for CES1 Gene

This gene is overexpressed in Liver (36.7) and Liver, secretome (9.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CES1 Gene

SOURCE GeneReport for Unigene cluster for CES1 Gene Hs.558865

mRNA Expression by UniProt/SwissProt for CES1 Gene

P23141-EST1_HUMAN
Tissue specificity: Expressed predominantly in liver with lower levels in heart and lung.
genes like me logo Genes that share expressions with CES1: view

In Situ Assay Products

No data available for Expression partners for CES1 Gene

Orthologs for CES1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CES1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CES1 35
  • 83.76 (n)
  • 80.25 (a)
-- 36
  • 77 (a)
OneToMany
BREH1 36
  • 72 (a)
OneToMany
CES1 36
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CES1 35
  • 83.48 (n)
  • 80 (a)
CESDD1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ces1d 35
  • 80.83 (n)
  • 78.23 (a)
Ces1g 16
Ces1a 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ces1d 35
  • 80.59 (n)
  • 77.52 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CES1 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves CES1 35
  • 59.46 (n)
  • 53.11 (a)
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493819 35
  • 56.46 (n)
  • 50.89 (a)
LOC394897 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-93f2.1 35
  • 54.35 (n)
  • 45.72 (a)
ces2 36
  • 41 (a)
ManyToMany
ces3 36
  • 42 (a)
ManyToMany
si:ch211-93f2.1 36
  • 14 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta alpha-Est10 37
  • 30 (a)
alpha-Est2 37
  • 29 (a)
alpha-Est4 37
  • 28 (a)
alpha-Est6 37
  • 30 (a)
alpha-Est7 37
  • 31 (a)
alpha-Est8 37
  • 31 (a)
alpha-Est9 37
  • 28 (a)
BcDNA:GH05741 37
  • 31 (a)
CG10175 37
  • 30 (a)
CG10339 37
  • 26 (a)
CG3841 37
  • 28 (a)
CG5397 37
  • 28 (a)
CG6018 37
  • 28 (a)
CG6414 37
  • 30 (a)
CG7529 37
  • 26 (a)
CG8424 37
  • 38 (a)
CG9289 37
  • 30 (a)
clt 37
  • 29 (a)
Est-6 37
  • 29 (a)
Est-P 37
  • 29 (a)
Jhe 37
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea B0238.1 37
  • 29 (a)
B0238.13 37
  • 38 (a)
B0238.7 37
  • 28 (a)
C52A10.1 37
  • 31 (a)
C52A10.2 37
  • 31 (a)
F07C4.12 37
  • 30 (a)
F13H6.3 37
  • 31 (a)
F13H6.4 37
  • 29 (a)
F15A8.6 37
  • 31 (a)
ges-1 37
  • 28 (a)
K07C11.4 37
  • 27 (a)
K11G9.1 37
  • 27 (a)
K11G9.2 37
  • 28 (a)
R173.3 37
  • 37 (a)
T02B5.1 37
  • 26 (a)
T02B5.3 37
  • 28 (a)
T07H6.1a 37
  • 27 (a)
Y71H2AM.13 37
  • 32 (a)
Y75B8A.3 37
  • 35 (a)
ZC376.2 37
  • 25 (a)
Species with no ortholog for CES1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CES1 Gene

ENSEMBL:
Gene Tree for CES1 (if available)
TreeFam:
Gene Tree for CES1 (if available)

Paralogs for CES1 Gene

Paralogs for CES1 Gene

Selected SIMAP similar genes for CES1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CES1 Gene

genes like me logo Genes that share paralogs with CES1: view

Variants for CES1 Gene

Sequence variations from dbSNP and Humsavar for CES1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1814268 -- 55,819,147(-) AGAAA(C/T)TGTCT intron-variant
rs1824141 -- 55,821,740(-) acagc(A/G)tcagg intron-variant
rs1833248 -- 55,824,516(-) ATTAT(C/T)AGTAC intron-variant
rs1833249 -- 55,821,059(-) CCTTC(A/C)CACTC intron-variant
rs1833250 -- 55,819,406(-) GGAAT(A/C)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CES1 Gene

Variant ID Type Subtype PubMed ID
dgv892e1 CNV Complex 17122850
nsv7284 OTHER Inversion 18451855
esv9707 OTHER Inversion 19470904
nsv147 OTHER Inversion 15895083
dgv2862n71 CNV Gain 21882294
dgv54e19 OTHER Inversion 19470904
esv998750 OTHER Inversion 20482838
nsv499134 OTHER Inversion 21111241
dgv15e197 OTHER Inversion 19546169
esv1010290 OTHER Inversion 20482838
esv9659 OTHER Inversion 19470904
dgv2863n71 CNV Gain 21882294
dgv2864n71 CNV Gain 21882294
dgv2865n71 CNV Gain 21882294
nsv471382 CNV Duplication 19718026
nsv820205 CNV Gain 19587683
dgv2866n71 CNV Gain 21882294
nsv906696 CNV Gain+Loss 21882294
dgv2867n71 CNV Gain 21882294
nsv9446 CNV Gain 18304495
esv28619 CNV Gain 19812545
dgv479n67 CNV Gain 20364138
nsv442724 CNV CNV 18776908
esv32573 CNV Gain+Loss 17666407
dgv2868n71 CNV Gain 21882294
dgv2869n71 CNV Gain 21882294
nsv906706 CNV Gain 21882294
nsv148 OTHER Inversion 15895083
nsv827676 CNV Gain 20364138

Relevant External Links for CES1 Gene

HapMap Linkage Disequilibrium report
CES1
Human Gene Mutation Database (HGMD)
CES1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CES1 Gene

Disorders for CES1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CES1 Gene in MalaCards »

(1) Diseases for CES1 Gene including...

(18) Novoseek inferred disease relationships for CES1 Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 55.1 23
leydig cell tumor 45.9 2
atherosclerotic plaque 38 1
hypercholesterolemia 29.8 5
coronary atherosclerosis 21.1 1

Relevant External Links for CES1

Genetic Association Database (GAD)
CES1
Human Genome Epidemiology (HuGE) Navigator
CES1
genes like me logo Genes that share disorders with CES1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CES1 Gene

Publications for CES1 Gene

  1. cDNA cloning and characterization of human monocyte/macrophage serine esterase-1. (PMID: 2070086) Zschunke F. … Radzun H.J. (Blood 1991) 2 3 4 23
  2. Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis. (PMID: 18485328) Zhu H.-J. … Markowitz J.S. (Am. J. Hum. Genet. 2008) 3 4 23 48
  3. Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine. From binding promiscuity to selective inhibition. (PMID: 12725862) Bencharit S. … Redinbo M.R. (Chem. Biol. 2003) 3 4 23
  4. A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases. (PMID: 1918003) Munger J.S. … Chapman H.A. (J. Biol. Chem. 1991) 3 4 23
  5. Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA. (PMID: 11015575) Ghosh S. (Physiol. Genomics 2000) 3 4 23

Products for CES1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Cellular Stress Responses in human,mouse,rat
    • Drug Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CES1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CES1
    • Block miRNA regulation of CES1 using miScript Target Protectors

    Sources for CES1 Gene

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