CES1 Gene
protein-coding GIFtS: 66
GCID: GC16M055836
|
|
carboxylesterase 1(Previous name: carboxylesterase 1 (monocyte/macrophage serine esterase...)
| |
Aliases
for CES1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Carboxylesterase 11 2 3 | | REH2 3 | | SES11 2 3 5 | | TGH2 3 | | CES21 2 3 | | HCE-11 | | HMSE1 2 3 | | EC 3.1.1.13 8 | | CEH1 2 | | CES1A11 | | HMSE11 2 | | CES1A21 | | Carboxylesterase 1 (Monocyte/Macrophage Serine Esterase 1)1 2 | | PCE-12 | | Acyl-Coenzyme A:Cholesterol Acyltransferase2 3 | | Acyl Coenzyme A:Cholesterol Acyltransferase2 | | Brain Carboxylesterase HBr12 3 | | Carboxylesterase 2 (Liver)2 | | Cocaine Carboxylesterase2 3 | | Cholesteryl Ester Hydrolase2 | | Methylumbelliferyl-Acetate Deacetylase 12 3 | | Egasyn3 | | Monocyte/Macrophage Serine Esterase2 3 | | Human Monocyte/Macrophage Serine Esterase 12 | | Retinyl Ester Hydrolase2 3 | | Liver Carboxylesterase 12 | | Serine Esterase 12 3 | | EC 3.1.1.563 | | Triacylglycerol Hydrolase2 3 | | Egasyn3 | | ACAT2 3 | | EC 3.1.18 | | CE-12 3 | | |
Export aliases for CES1 gene to outside databasesPrevious GC identifers: GC16M046044 GC16P055849 GC16P055518 GC16M055613 GC16M055615 GC16M054395 GC06P023997 |
Summaries
for CES1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CES1:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysisor transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester,thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role inthe blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutationsof this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms havebeen found for this gene. (provided by RefSeq, Jun 2010)
UniProtKB/Swiss-Prot: EST1_HUMAN, P23141Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzesaromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes themethyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to formcocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid toethyloleate
Gene Wiki entry for CES1 (Carboxylesterase 1)
|
Genomic Views
for CES1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CES1 gene promoter:
TBP AP-1 ATF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CES1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CES1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.2 Ensembl cytogenetic band: 16q12.2 HGNC cytogenetic band: 16q22.2CES1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M055836: view genomic region
(about GC identifiers)
Start:
|
55,836,763 bp from pter |
End:
|
55,867,249 bp from pter |
Size:
|
30,487 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr16-,PATCHES 55,849,148-55,879,492 |
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Proteins
for CES1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: EST1_HUMAN, P23141 (See
protein sequence)Recommended Name: Liver carboxylesterase 1 precursor Size: 567 amino acids; 62521 Da
Subunit: Homotrimer and homohexamer. Binds to beta-glucuronidase
Subcellular location: Endoplasmic reticulum lumen
Sequence caution: Sequence=AAA83932.1; Type=Frameshift; Positions=301, 312, 318, 383, 391;
6/15 PDB 3D structures from  and Proteopedia  for CES1 (see all 15):1MX1 (3D)
1MX5 (3D)
1MX9 (3D)
1YA4 (3D)
1YA8 (3D)
1YAH (3D)
Secondary accessions: A6NIM1 A8K3K8 A8K844 P82127 Q00015 Q13657 Q14062 Q16737 Q16788 Q549X7 Q549X8Q86UK2 Q96EE8 Q9UC52 Q9UDG8 Q9UK77 Q9ULY2Alternative splicing: 2 isoforms: P23141-1 P23141-2 Explore the universe of human proteins at neXtProt for CES1: NX_P23141
Post-translational modifications:
Contains sialic acid1
Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-191
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P23141
4/19 DME Specific Peptides for CES1 (P23141) (see all 19)
CES1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001020365.1 NP_001020366.1 NP_001257.4
ENSEMBL proteins: ENSP00000455902 ENSP00000353720 ENSP00000390492 ENSP00000455959 ENSP00000355193 ENSP00000456865
Human Recombinant Protein Products for CES1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005788 | endoplasmic reticulum lumen |
IEA | -- |
CES1 for ontologies About GeneDecksing
CES1 Antibody Products:
Assay Products for CES1: |
Protein
Domains /
Families
for CES1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CES1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P23141ProtoNet protein and cluster: P23141 UniProtKB/Swiss-Prot: EST1_HUMAN, P23141Similarity: Belongs to the type-B carboxylesterase/lipase family |
Function
for CES1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: EST1_HUMAN, P23141Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzesaromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes themethyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to formcocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid toethyloleateCatalytic activity: A carboxylic ester + H(2)O = an alcohol + a carboxylateCatalytic activity: 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetateEnzyme regulation: Activated by CHAPSBiophysicochemical properties: Kinetic parameters: KM=106.6 uM for p-nitrophenyl acetate; KM=775.7 uM forL-methylphenidate; KM=663.5 uM for D-methylphenidate; KM=116 uM for cocaine; KM=43 mM for ethanol; KM=0.8 mM for4-methylumbelliferyl acetate; KM=6.3 mM for heroin; KM=8.3 mM for 6-monoacetylmorphine; Vmax=493.9 nmol/min/mg enzymewith p-nitrophenyl acetate as substrate; Vmax=1701.1 pmol/min/mg enzyme with L-methylphenidate as substrate;Vmax=177.2 pmol/min/mg enzyme with D-methylphenidate as substrate; pH dependence: Optimum pH is 6.5; Genatlas biochemistry entry for CES1:carboxylesterase 1,expressed in brain,located in the endoplasmic reticulum,catalyzing the hydrolysis oftemocapril,p-nitrophenyl-acetate and long chain acyl-CoA,putatively functioning as a blood-brain barrier to protectthe CNS from ester or amide compounds
Enzyme Numbers (IUBMB): EC 3.1.1.11 2 EC 3.1.12 EC 3.1.1.561
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004091 | carboxylesterase activity |
IBA | -- | | GO:0016787 | hydrolase activity |
-- | -- | | GO:0047374 | methylumbelliferyl-acetate deacetylase activity |
IEA | -- | | GO:0050253 | retinyl-palmitate esterase activity |
IEA | -- | | GO:0080030 | methyl indole-3-acetate esterase activity |
IEA | -- |
CES1 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for CES1:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CES1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CES1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): CES1 (NM_001266) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CES1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CES1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES1 |
|
Pathways & Interactions
for CES1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Irinotecan Pathway, Pharmacokinetics | | | 2 | Fluoropyrimidine Activity | | | 3 | E2F transcription factor network | | | 4 | the visual cycle I (vertebrates) | | | 5 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  GeneGo (Thomson Reuters) Pathway for CES1
4  BioSystems Pathways for CES1
5  PharmGKB Pathways for CES1
2 
Kegg Pathways (Kegg details for CES1):
CES1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CES1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/12 Interacting proteins for CES1 (P231413 ENSP000003537204) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
CES1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CES1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CES1 for compounds About GeneDecksing
 Browse Tocris compounds for CES1
10/334 HMDB Compounds for CES1 (see all 334) About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| TG(15:0/16:0/20:2(11Z,14Z))[iso6] | Tracylglycerol(15:0/16:0/20:2) (see all 15) | -- | 12486725 | | TG(15:0/16:0/20:3(8Z,11Z,14Z))[iso6] | TAG(15:0/16:0/20:3n6) (see all 16) | -- | 12486725 | | TG(15:0/16:0/20:4(5Z,8Z,11Z,14Z))[iso6] | TAG(15:0/16:0/20:4n6) (see all 15) | -- | 12486725 | | TG(15:0/18:0/18:2(9Z,12Z))[iso6] | TG(15:0/18:0/18:2w6) (see all 15) | -- | 12486725 | | TG(15:0/18:0/18:3(9Z,12Z,15Z))[iso6] | TAG(51:3) (see all 16) | -- | 12486725 | | TG(15:0/18:1(9Z)/16:0)[iso6] | Tracylglycerol(15:0/18:1w9/16:0) (see all 15) | -- | 12486725 | | TG(15:0/18:1(9Z)/16:1(9Z))[iso6] | TG(15:0/18:1/16:1) (see all 15) | -- | 12486725 | | TG(15:0/18:1(9Z)/18:1(9Z))[iso3] | TG(15:0/18:1n9/18:1n9) (see all 15) | -- | 12486725 | | TG(15:0/18:1(9Z)/18:2(9Z,12Z))[iso6] | Tracylglycerol(15:0/18:1/18:2) (see all 15) | -- | 12486725 | | TG(15:0/18:1(9Z)/18:3(9Z,12Z,15Z))[iso6] | Tracylglycerol(15:0/18:1/18:3) (see all 16) | -- | 12486725 |
10/20 DrugBank Compounds for CES1 (see all 20) About this table
| Compound | Synonyms |
CAS
# | Type | Actions | PubMed Ids |
|---|
| Capecitabine | -- | 154361-50-9 | enzyme | substrate | 11291832 12866042 10630095 11587492 11081570 | | Alpha-D-Mannose | -- | 3458-28-4 | target | -- | 17139284 17016423 10592235 | | Irinotecan | Irinotecan Hcl (see all 4) | 100286-90-6 | enzyme | substrate | 19852077 9342501 9726089 | | Oseltamivir | -- | 204255-11-8 | target | other | 16966469 19104028 19022936 | | Thenoyltrifluoroacetone | .alpha.-Thenoyltrifluoroacetone (see all 7) | 326-91-0 | target | -- | 11992644 10592235 | | (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE | -- | -- | target | -- | 10592235 | | (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL | -- | -- | target | -- | 10592235 | | 4-Piperidino-Piperidine | -- | -- | target | -- | 10592235 | | Benzocaine | Ethyl Aminobenzoate (see all 7) | 94-09-7 | enzyme | inhibitor | 7470208 | | Cholic Acid | -- | 81-25-4 | target | -- | 10592235 |
10/84 Novoseek chemical compound relationships for CES1 gene (see all 84) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cl 277082 |
88.2 |
3 |
9500571 (1), 8695654 (1), 11882317 (1) |
| 4-methylumbelliferyl acetate |
83.9 |
3 |
9169443 (2), 14581373 (1) |
| avasimibe |
83.8 |
10 |
12360153 (2), 12595916 (2), 15678619 (2), 15533865 (1) (see all 6) |
| 3-(decyldimethylsilyl)-n-(2-(4-methylphenyl)-1-phenylethyl)propanamide |
83.1 |
3 |
16835370 (1), 14617686 (1) |
| 2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)dodecanamide |
82.1 |
5 |
1675757 (2), 15169972 (1), 7815329 (1) |
| cholesteryl oleate |
81.9 |
1 |
9500571 (1) |
| pyripyropene a |
81 |
2 |
10890154 (1), 9127194 (1) |
| diethylumbelliferyl phosphate |
80.7 |
1 |
7835165 (1) |
| cholesterol ester |
78.7 |
20 |
8025134 (1), 9559268 (1), 11676294 (1), 16962139 (1) (see all 12) |
| cholesterol |
78.4 |
323 |
8185666 (9), 9500571 (6), 7756263 (4), 8695654 (4) (see all 99) |
1 PharmGKB related drug/compound annotation for CES1 gene About this tableSearch CenterWatch for drugs/clinical trials and news about CES1 / EST1
|
Transcripts
for CES1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CES1 gene (3 alternative transcripts): NM_001025194.1 NM_001025195.1 NM_001266.4 Unigene Cluster for CES1: Carboxylesterase 1 Hs.558865 [show with all ESTs]Unigene Representative Sequence: NM_0010251959 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000565568 ENST00000360526(uc002eil.3) ENST00000422046(uc002eim.3 uc002ein.3)
ENST00000563241 ENST00000361503 ENST00000569260 ENST00000563005 ENST00000565403
ENST00000566555
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CES1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CES1 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): CES1 (NM_001266) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CES1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CES1 |
Additional cDNA sequence: AB025026.1 AB119995.1 AB119996.1 AF177775.1 AK290623.1 AK292209.1 AK301651.1 AY268104.1 BC012418.1 BC110338.1 L07764.1 L07765.1 M55509.1 M65261.1 M73499.1 S73751.1 X52973.1 14 DOTS entries: DT.455216 DT.100828227 DT.95133731 DT.99982604 DT.100718449 DT.120708401 DT.92437980 DT.100828223 DT.86855737 DT.92437982 DT.97858163 DT.100037180 DT.100828228 DT.95133747 24/277 AceView cDNA sequences (see all 277): BU741184 BI906521 AI129284 BQ775275 BI835467 CA308899 AB119995 CA310133 BU164515 AB025026 CB164600 BU678185 BM708510 AW138926 CD706259 BU732288 CB154136 BX107798 CB110009 BQ774702 BI822226 CB162528 CA438448 AW006490
GeneLoc Exon Structure
|
Expression
for CES1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CES1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGAGCAAG
About this image
See CES1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CES1
SOURCE GeneReport for Unigene cluster: Hs.558865
UniProtKB/Swiss-Prot: EST1_HUMAN, P23141Tissue specificity: Expressed predominantly in liver with lower levels in heart and lung
SABiosciences Expression via Pathway-Focused PCR Arrays including CES1: | Drug Metabolism: Phase II Enzymes in human mouse rat | | Cellular Stress Responses in human mouse rat | | Drug Metabolism in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CES1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CES1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CES1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CES1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES1 |
Orthologs
for CES1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CES1 gene from 4/14 species (see all 14) About this table
ENSEMBL Gene Tree for CES1 (if available)
TreeFam Gene Tree for CES1 (if available) |
Paralogs
for CES1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CES1 gene
- NLGN12 CES22 ACHE2 CES4A2 NLGN4X2 NLGN4Y2 CES32 NLGN32
- NLGN22 CEL2 BCHE2 CES5A2
13 SIMAP similar genes for CES1 using alignment to 6 protein entries: EST1_HUMAN (see all proteins):CES1P1 CES hBr2 CES8 CES3 CES4A CES2
CES5A DKFZp686F02202 NLGN3 ACHE BCHE CEL
NLGN1
CES1 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for CES1
PGOHUM00000262339 PGOHUM00000250685 PGOHUM00000262340
|
Genomic Variants
for CES1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CES1 (55836763 - 55867249 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for CES1
6 CNVs: 67001 37794 4007 30784 58763 7118
5 Inversions: 59912 0488 0487 103337 37182
Human Gene Mutation Database (HGMD): CES1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CES1 |
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Disorders
/ Diseases
for CES1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CES1 for disorders About GeneDecksing
OMIM gene information: 114835
OMIM disorders: --
20/34  diseases for CES1 (see all 34): About MalaCardscarboxylesterase 1 deficiency cholesterol niemann-pick disease leydig cell tumor
hepatic lipase deficiency intrahepatic cholestasis intrahepatic cholestasis of pregnancy pick's disease
reye syndrome cholestasis hypertriglyceridemia hyperlipoproteinemia
intrahepatic cholangiocarcinoma hypercholesterolemia alzheimer's disease autoimmune hepatitis
atherosclerosis hepatitis c adhd influenza
10/18 Novoseek disease relationships for CES1 gene (see all 18) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| atherosclerosis |
55.1 |
30 |
16518538 (3), 11461099 (2), 12360153 (2), 17885686 (2) (see all 17) |
| leydig cell tumor |
45.9 |
2 |
1332853 (2) |
| atherosclerotic plaque |
38 |
1 |
16971496 (1) |
| hypercholesterolemia |
29.8 |
6 |
10638223 (1), 8953507 (1), 8230120 (1), 7815329 (1) (see all 5) |
| coronary atherosclerosis |
21.1 |
1 |
12360153 (1) |
| colon carcinoma |
19.7 |
5 |
16963839 (2), 17146959 (1), 1639221 (1), 1892896 (1) |
| fatty liver |
11.7 |
2 |
9219899 (1), 12822207 (1) |
| necrosis |
4.68 |
2 |
8920872 (1), 17885686 (1) |
| hypertriglyceridemia |
0 |
1 |
16403839 (1) |
| cardiovascular diseases |
0 |
1 |
12437499 (1) |
Genetic Association Database (GAD): CES1
Human Genome Epidemiology (HuGE) Navigator: CES1 (12 documents)
Export disorders for CES1 gene to outside databases
|
Publications
for CES1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CES1 gene, integrated from 9 sources (see all 345):
(articles sorted by number of sources associating them with CES1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning and characterization of human monocyte/macrophage serine esterase-1. (PubMed id 2070086)1, 2, 3, 9 Zschunke F....Radzun H.J. (1991)
- Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA. (PubMed id 11015575)1, 2, 9 Ghosh S. (2000)
- Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene. (PubMed id 15475733)1, 4, 9 Wu M.H....Dolan M.E. (2004)
- Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis. (PubMed id 18485328)1, 2, 9 Zhu H.J....Markowitz J.S. (2008)
- Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase. (PubMed id 8049197)1, 2, 9 Becker A.... Schmitz G. (1994)
- Heterologous expression, purification, and characterization of human triacylglycerol hydrolase. (PubMed id 11812220)1, 2, 9 Alam M.... Lehner R. (2002)
- Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site. (PubMed id 12022871)1, 2, 9 Alam M.... Lehner R. (2002)
- Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine. From binding promiscuity to selective inhibition. (PubMed id 12725862)1, 2, 9 Bencharit S.... Redinbo M.R. (2003)
- Irinotecan pathway genotype analysis to predict pharmacokinetics. (PubMed id 12960109)1, 4, 9 Mathijssen R.H....McLeod H.L. (2003)
- Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. (PubMed id 12679808)1, 2, 9 Bencharit S.... Redinbo M.R. (2003)
|
External Searches for CES1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CES1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CES1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CES1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CES1 gene:
Search GeneIP for patents involving CES1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CES1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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