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Aliases for CES1 Gene

Aliases for CES1 Gene

  • Carboxylesterase 1 2 3 4 5
  • Carboxylesterase 1 (Monocyte/Macrophage Serine Esterase 1) 2 3
  • Human Monocyte/Macrophage Serine Esterase 1 2 3
  • Acyl-Coenzyme A:Cholesterol Acyltransferase 3 4
  • Methylumbelliferyl-Acetate Deacetylase 1 3 4
  • Monocyte/Macrophage Serine Esterase 3 4
  • Brain Carboxylesterase HBr1 3 4
  • Triacylglycerol Hydrolase 3 4
  • Cocaine Carboxylesterase 3 4
  • Retinyl Ester Hydrolase 3 4
  • Serine Esterase 1 3 4
  • EC 3.1.1.1 4 63
  • Egasyn 3 4
  • HCE-1 3 4
  • ACAT 3 4
  • CE-1 3 4
  • CES2 3 4
  • HMSE 3 4
  • SES1 3 4
  • REH 3 4
  • TGH 3 4
  • Acyl Coenzyme A:Cholesterol Acyltransferase 3
  • Cholesteryl Ester Hydrolase 3
  • Carboxylesterase 2 (Liver) 3
  • EC 3.1.1.56 4
  • EC 3.1.1 63
  • HMSE1 3
  • PCE-1 3
  • CEH 3

External Ids for CES1 Gene

Previous GeneCards Identifiers for CES1 Gene

  • GC16M046044
  • GC16P055849
  • GC16P055518
  • GC16M055613
  • GC16M055615
  • GC16M054395
  • GC06P023997

Summaries for CES1 Gene

Entrez Gene Summary for CES1 Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for CES1 Gene

CES1 (Carboxylesterase 1) is a Protein Coding gene. Diseases associated with CES1 include cystic echinococcosis and sparganosis. Among its related pathways are Metabolism and cytochrome P450. GO annotations related to this gene include hydrolase activity and methylumbelliferyl-acetate deacetylase activity. An important paralog of this gene is CES2.

UniProtKB/Swiss-Prot for CES1 Gene

  • Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.

Gene Wiki entry for CES1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES1 Gene

Genomics for CES1 Gene

Regulatory Elements for CES1 Gene

Transcription factor binding sites by QIAGEN in the CES1 gene promoter:

Genomic Location for CES1 Gene

Chromosome:
16
Start:
55,802,851 bp from pter
End:
55,833,337 bp from pter
Size:
30,487 bases
Orientation:
Minus strand

Genomic View for CES1 Gene

Genes around CES1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CES1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CES1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES1 Gene

Proteins for CES1 Gene

  • Protein details for CES1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23141-EST1_HUMAN
    Recommended name:
    Liver carboxylesterase 1
    Protein Accession:
    P23141
    Secondary Accessions:
    • A6NIM1
    • A8K3K8
    • A8K844
    • E9PAU8
    • P82127
    • Q00015
    • Q13657
    • Q14062
    • Q16737
    • Q16788
    • Q549X7
    • Q549X8
    • Q86UK2
    • Q96EE8
    • Q9UC52
    • Q9UDG8
    • Q9UK77
    • Q9ULY2

    Protein attributes for CES1 Gene

    Size:
    567 amino acids
    Molecular mass:
    62521 Da
    Quaternary structure:
    • Homotrimer and homohexamer. Binds to beta-glucuronidase.
    SequenceCaution:
    • Sequence=AAA83932.1; Type=Frameshift; Positions=301, 312, 318, 383, 391; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CES1 Gene

    Alternative splice isoforms for CES1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CES1 Gene

Proteomics data for CES1 Gene at MOPED

Post-translational modifications for CES1 Gene

  • Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19.
  • Contains sialic acid.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for CES1 (Carboxylesterase 1/CES1)

Domains & Families for CES1 Gene

Gene Families for CES1 Gene

Protein Domains for CES1 Gene

Suggested Antigen Peptide Sequences for CES1 Gene

Graphical View of Domain Structure for InterPro Entry

P23141

UniProtKB/Swiss-Prot:

EST1_HUMAN :
  • Belongs to the type-B carboxylesterase/lipase family.
Family:
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES1: view

Function for CES1 Gene

Molecular function for CES1 Gene

GENATLAS Biochemistry:
carboxylesterase 1,expressed in brain,located in the endoplasmic reticulum,catalyzing the hydrolysis of temocapril,p-nitrophenyl-acetate and long chain acyl-CoA,putatively functioning as a blood-brain barrier to protect the CNS from ester or amide compounds
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=106.6 uM for p-nitrophenyl acetate {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; KM=775.7 uM for L-methylphenidate {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; KM=663.5 uM for D-methylphenidate {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; KM=116 uM for cocaine {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; KM=43 mM for ethanol {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; KM=0.8 mM for 4-methylumbelliferyl acetate {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; KM=6.3 mM for heroin {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; KM=8.3 mM for 6-monoacetylmorphine {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; Vmax=493.9 nmol/min/mg enzyme with p-nitrophenyl acetate as substrate {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; Vmax=1701.1 pmol/min/mg enzyme with L-methylphenidate as substrate {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; Vmax=177.2 pmol/min/mg enzyme with D-methylphenidate as substrate {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062}; pH dependence: Optimum pH is 6.5. {ECO:0000269 PubMed:18485328, ECO:0000269 PubMed:7980644, ECO:0000269 PubMed:9169443, ECO:0000269 PubMed:9490062};
UniProtKB/Swiss-Prot CatalyticActivity:
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity:
4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by CHAPS.
UniProtKB/Swiss-Prot Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.

Enzyme Numbers (IUBMB) for CES1 Gene

genes like me logo Genes that share phenotypes with CES1: view

Human Phenotype Ontology for CES1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CES1 Gene

MGI Knock Outs for CES1:

Animal Model Products

miRNA for CES1 Gene

miRTarBase miRNAs that target CES1

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for CES1 Gene

Localization for CES1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES1 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CES1 Gene COMPARTMENTS Subcellular localization image for CES1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 4
cytosol 3
vacuole 2
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CES1 Gene

Pathways & Interactions for CES1 Gene

genes like me logo Genes that share pathways with CES1: view

Interacting Proteins for CES1 Gene

Gene Ontology (GO) - Biological Process for CES1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process TAS 1918003
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CES1: view

No data available for SIGNOR curated interactions for CES1 Gene

Drugs & Compounds for CES1 Gene

(74) Drugs for CES1 Gene - From: DGIdb, HMDB, Novoseek, DrugBank, PharmGKB, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Capecitabine Approved, Investigational Pharma Enzyme, substrate RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1220
cholic acid Approved Pharma Full agonist, Agonist, Target 0
Cyclandelate Approved Pharma Target 0
Irinotecan Approved, Investigational Pharma Enzyme, substrate Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1044
Oseltamivir Approved Pharma Target, other 93

(93) Additional Compounds for CES1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Methylumbelliferyl acetate
  • 4-Methyl-7-acetyloxy coumarin
  • 4-Methylumbelliferyl acetate
  • 7-(Acetyloxy)-4-methyl-2-benzopyrone
  • 7-Acetoxy-4-methyl-2H-1-benzopyran-2-one
  • 7-Acetoxy-4-methylcoumarin
2747-05-9
1,4'-Bipiperidine-1'-carboxylic acid
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
4-Amino-1-piperidinecarboxylic acid
4-methylumbelliferone
genes like me logo Genes that share compounds with CES1: view

Transcripts for CES1 Gene

Unigene Clusters for CES1 Gene

Carboxylesterase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CES1 Gene

No ASD Table

Relevant External Links for CES1 Gene

GeneLoc Exon Structure for
CES1
ECgene alternative splicing isoforms for
CES1

Expression for CES1 Gene

mRNA expression in normal human tissues for CES1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CES1 Gene

This gene is overexpressed in Liver (x23.9).

Protein differential expression in normal tissues from HIPED for CES1 Gene

This gene is overexpressed in Liver (36.7) and Liver, secretome (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CES1 Gene



SOURCE GeneReport for Unigene cluster for CES1 Gene Hs.558865

mRNA Expression by UniProt/SwissProt for CES1 Gene

P23141-EST1_HUMAN
Tissue specificity: Expressed predominantly in liver with lower levels in heart and lung.
genes like me logo Genes that share expression patterns with CES1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CES1 Gene

Orthologs for CES1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CES1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CES1 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 77 (a)
OneToMany
BREH1 36
  • 72 (a)
OneToMany
CES1 36
  • 80 (a)
OneToMany
CES1 35
  • 83.76 (n)
  • 80.25 (a)
dog
(Canis familiaris)
Mammalia CES1 35
  • 83.48 (n)
  • 80 (a)
CESDD1 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ces1d 35
  • 80.83 (n)
  • 78.23 (a)
Ces1d 16
Ces1a 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
OneToMany
-- 36
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 61 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ces1d 35
  • 80.59 (n)
  • 77.52 (a)
chicken
(Gallus gallus)
Aves CES1 35
  • 59.46 (n)
  • 53.11 (a)
-- 36
  • 52 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493819 35
  • 56.46 (n)
  • 50.89 (a)
LOC394897 35
zebrafish
(Danio rerio)
Actinopterygii ces2 36
  • 41 (a)
ManyToMany
ces3 36
  • 42 (a)
ManyToMany
si:ch211-93f2.1 36
  • 14 (a)
ManyToMany
si:ch211-93f2.1 35
  • 54.35 (n)
  • 45.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta alpha-Est10 37
  • 30 (a)
alpha-Est2 37
  • 29 (a)
alpha-Est4 37
  • 28 (a)
alpha-Est6 37
  • 30 (a)
alpha-Est7 37
  • 31 (a)
alpha-Est8 37
  • 31 (a)
alpha-Est9 37
  • 28 (a)
BcDNA:GH05741 37
  • 31 (a)
CG10175 37
  • 30 (a)
CG10339 37
  • 26 (a)
CG3841 37
  • 28 (a)
CG5397 37
  • 28 (a)
CG6018 37
  • 28 (a)
CG6414 37
  • 30 (a)
CG7529 37
  • 26 (a)
CG8424 37
  • 38 (a)
CG9289 37
  • 30 (a)
clt 37
  • 29 (a)
Est-6 37
  • 29 (a)
Est-P 37
  • 29 (a)
Jhe 37
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea B0238.1 37
  • 29 (a)
B0238.13 37
  • 38 (a)
B0238.7 37
  • 28 (a)
C52A10.1 37
  • 31 (a)
C52A10.2 37
  • 31 (a)
F07C4.12 37
  • 30 (a)
F13H6.3 37
  • 31 (a)
F13H6.4 37
  • 29 (a)
F15A8.6 37
  • 31 (a)
ges-1 37
  • 28 (a)
K07C11.4 37
  • 27 (a)
K11G9.1 37
  • 27 (a)
K11G9.2 37
  • 28 (a)
R173.3 37
  • 37 (a)
T02B5.1 37
  • 26 (a)
T02B5.3 37
  • 28 (a)
T07H6.1a 37
  • 27 (a)
Y71H2AM.13 37
  • 32 (a)
Y75B8A.3 37
  • 35 (a)
ZC376.2 37
  • 25 (a)
Species with no ortholog for CES1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CES1 Gene

ENSEMBL:
Gene Tree for CES1 (if available)
TreeFam:
Gene Tree for CES1 (if available)

Paralogs for CES1 Gene

Paralogs for CES1 Gene

(12) SIMAP similar genes for CES1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CES1 Gene

genes like me logo Genes that share paralogs with CES1: view

Variants for CES1 Gene

Sequence variations from dbSNP and Humsavar for CES1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_014314 -
VAR_014594 -
VAR_014595 -
VAR_046954 -
rs3859097 -- 55,831,866(-) ACTGA(A/G)ACTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CES1 Gene

Variant ID Type Subtype PubMed ID
dgv892e1 CNV Complex 17122850
nsv7284 OTHER Inversion 18451855
esv9707 OTHER Inversion 19470904
nsv147 OTHER Inversion 15895083
dgv2862n71 CNV Gain 21882294
dgv54e19 OTHER Inversion 19470904
esv998750 OTHER Inversion 20482838
nsv499134 OTHER Inversion 21111241
dgv15e197 OTHER Inversion 19546169
esv1010290 OTHER Inversion 20482838
esv9659 OTHER Inversion 19470904
dgv2863n71 CNV Gain 21882294
dgv2864n71 CNV Gain 21882294
dgv2865n71 CNV Gain 21882294
nsv471382 CNV Duplication 19718026
nsv820205 CNV Gain 19587683
dgv2866n71 CNV Gain 21882294
nsv906696 CNV Gain+Loss 21882294
dgv2867n71 CNV Gain 21882294
nsv9446 CNV Gain 18304495
esv28619 CNV Gain 19812545
dgv479n67 CNV Gain 20364138
nsv442724 CNV CNV 18776908
esv32573 CNV Gain+Loss 17666407
dgv2868n71 CNV Gain 21882294
dgv2869n71 CNV Gain 21882294
nsv906706 CNV Gain 21882294
nsv148 OTHER Inversion 15895083
nsv827676 CNV Gain 20364138

Variation tolerance for CES1 Gene

Residual Variation Intolerance Score: 98.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.79; 79.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CES1 Gene

HapMap Linkage Disequilibrium report
CES1
Human Gene Mutation Database (HGMD)
CES1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CES1 Gene

Disorders for CES1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for CES1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cystic echinococcosis
  • echinococcus granulosus infection
sparganosis
  • infection by sparganum
pellagra
  • niacin deficiency
prostate carcinoma in situ
  • carcinoma in situ of prostate
reye syndrome
  • reye's syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CES1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CES1

Genetic Association Database (GAD)
CES1
Human Genome Epidemiology (HuGE) Navigator
CES1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CES1
genes like me logo Genes that share disorders with CES1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CES1 Gene

Publications for CES1 Gene

  1. Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis. (PMID: 18485328) Zhu H.-J. … Markowitz J.S. (Am. J. Hum. Genet. 2008) 3 4 23 48 67
  2. Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril. (PMID: 19185566) Zhu H.J. … Markowitz J.S. (Biochem. Pharmacol. 2009) 3 23 25
  3. Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants. (PMID: 19022936) Zhu H.J. … Markowitz J.S. (Drug Metab. Dispos. 2009) 23 25 26
  4. Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel. (PMID: 16966469) Shi D. … Yan B. (J. Pharmacol. Exp. Ther. 2006) 23 25 26
  5. Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. (PMID: 16081098) Fleming C.D. … Redinbo M.R. (J. Mol. Biol. 2005) 23 25 26

Products for CES1 Gene

Sources for CES1 Gene

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