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CES1 Gene

protein-coding   GIFtS: 67
GCID: GC16M055836

Carboxylesterase 1

(Previous name: carboxylesterase 1 (monocyte/macrophage serine esterase...)
  See CES1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxylesterase 11 2 3     REH2 3
SES12 3 5     TGH2 3
Carboxylesterase 1 (Monocyte/Macrophage Serine Esterase 1)1 2     hCE-12 3
Human Monocyte/Macrophage Serine Esterase 11 2     EC 3.1.1.13 8
Acyl-Coenzyme A:Cholesterol Acyltransferase2 3     CEH2
Brain Carboxylesterase HBr12 3     HMSE12
Cocaine Carboxylesterase2 3     PCE-12
Methylumbelliferyl-Acetate Deacetylase 12 3     Acyl Coenzyme A:Cholesterol Acyltransferase2
Monocyte/Macrophage Serine Esterase2 3     Carboxylesterase 2 (Liver)2
Retinyl Ester Hydrolase2 3     Cholesteryl Ester Hydrolase2
Serine Esterase 12 3     egasyn2
Triacylglycerol Hydrolase2 3     Liver Carboxylesterase 12
ACAT2 3     EC 3.1.1.563
CE-12 3     Egasyn3
CES22 3     EC 3.1.18
HMSE2 3     

External Ids:    HGNC: 18631   Entrez Gene: 10662   Ensembl: ENSG000001988487   OMIM: 1148355   UniProtKB: P231413   

Export aliases for CES1 gene to outside databases

Previous GC identifers: GC16M046044 GC16P055849 GC16P055518 GC16M055613 GC16M055615 GC16M054395 GC06P023997


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CES1 Gene:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the
hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates
with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and
may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver
drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding
three different isoforms have been found for this gene. (provided by RefSeq, Jun 2010)

GeneCards Summary for CES1 Gene:
CES1 (carboxylesterase 1) is a protein-coding gene. Diseases associated with CES1 include carboxylesterase 1 deficiency, and reye syndrome. GO annotations related to this gene include and methylumbelliferyl-acetate deacetylase activity. An important paralog of this gene is NLGN1.

UniProtKB/Swiss-Prot: EST1_HUMAN, P23141
Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester.
Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of
cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl
esterification of oleic acid to ethyloleate

Gene Wiki entry for CES1 (Carboxylesterase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CES1 gene promoter:
         TBP   AP-1   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCES1 promoter sequence
   Search Chromatin IP Primers for CES1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CES1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q22.2

CES1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CES1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M055836:  view genomic region     (about GC identifiers)

Start:
55,836,763 bp from pter      End:
55,867,249 bp from pter
Size:
30,487 bases      Orientation:
minus strand

1 alternative location:
Chr16-,NW_003315945 26,724-57,068     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EST1_HUMAN, P23141 (See protein sequence)
Recommended Name: Liver carboxylesterase 1 precursor  
Size: 567 amino acids; 62521 Da
Subunit: Homotrimer and homohexamer. Binds to beta-glucuronidase
Sequence caution: Sequence=AAA83932.1; Type=Frameshift; Positions=301, 312, 318, 383, 391;
Selected PDB 3D structures from and Proteopedia for CES1 (see all 15):
1MX1 (3D)        1MX5 (3D)        1MX9 (3D)        1YA4 (3D)        1YA8 (3D)        1YAH (3D)    
Secondary accessions: A6NIM1 A8K3K8 A8K844 E9PAU8 P82127 Q00015 Q13657 Q14062 Q16737 Q16788
Q549X7 Q549X8 Q86UK2 Q96EE8 Q9UC52 Q9UDG8 Q9UK77 Q9ULY2
Alternative splicing: 3 isoforms:  P23141-1   P23141-2   P23141-3   

Explore the universe of human proteins at neXtProt for CES1: NX_P23141

Explore proteomics data for CES1 at MOPED

Post-translational modifications: 

  • Contains sialic acid1
  • Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and
    His-191
  • Glycosylation2 at Asn79
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CES1 (P23141) (see all 19)
     NIASFGG  LSKMVMK  AALRWVQ  HRDAGAP 


    See CES1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001020365.1  NP_001020366.1  NP_001257.4  

    ENSEMBL proteins: 
     ENSP00000455902   ENSP00000353720   ENSP00000390492   ENSP00000455959   ENSP00000355193  
     ENSP00000456865  

    CES1 Human Recombinant Protein Products:

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    OriGene Purified Proteins for CES1
    OriGene Protein Over-expression Lysate for CES1
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    GenScript Custom Purified and Recombinant Proteins Services for CES1
    Novus Biologicals CES1 Protein
    Novus Biologicals CES1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CES1

     
    Search eBioscience for Proteins for CES1 

     
    antibodies-online proteins for CES1 (8 products) 

     
    antibodies-online peptides for CES1

    CES1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CES1
    R&D Systems Antibodies for CES1 (Carboxylesterase 1/CES1)
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    antibodies-online antibodies for CES1 (38 products) 

    CES1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CES1
    Cloud-Clone Corp. CLIAs for CES1
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    antibodies-online kits for CES1 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CES: Carboxylesterases

    3 InterPro protein domains:
     IPR019826 Carboxylesterase_B_AS
     IPR019819 Carboxylesterase_B_CS
     IPR002018 CarbesteraseB

    Graphical View of Domain Structure for InterPro Entry P23141

    ProtoNet protein and cluster: P23141

    UniProtKB/Swiss-Prot: EST1_HUMAN, P23141
    Similarity: Belongs to the type-B carboxylesterase/lipase family


    Find genes that share domains with CES1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EST1_HUMAN, P23141
    Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.
    Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester.
    Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of
    cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl
    esterification of oleic acid to ethyloleate
    Catalytic activity: A carboxylic ester + H(2)O = an alcohol + a carboxylate
    Catalytic activity: 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate
    Enzyme regulation: Activated by CHAPS
    Biophysicochemical properties: Kinetic parameters: KM=106.6 uM for p-nitrophenyl acetate; KM=775.7 uM for
    L-methylphenidate; KM=663.5 uM for D-methylphenidate; KM=116 uM for cocaine; KM=43 mM for ethanol; KM=0.8 mM for
    4-methylumbelliferyl acetate; KM=6.3 mM for heroin; KM=8.3 mM for 6-monoacetylmorphine; Vmax=493.9 nmol/min/mg
    enzyme with p-nitrophenyl acetate as substrate; Vmax=1701.1 pmol/min/mg enzyme with L-methylphenidate as
    substrate; Vmax=177.2 pmol/min/mg enzyme with D-methylphenidate as substrate; pH dependence: Optimum pH is 6.5;

         Genatlas biochemistry entry for CES1:
    carboxylesterase 1,expressed in brain,located in the endoplasmic reticulum,catalyzing the hydrolysis of
    temocapril,p-nitrophenyl-acetate and long chain acyl-CoA,putatively functioning as a blood-brain barrier to
    protect the CNS from ester or amide compounds

         Enzyme Numbers (IUBMB): EC 3.1.1.11 2 EC 3.1.12 EC 3.1.1.561

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity ----
    GO:0047374methylumbelliferyl-acetate deacetylase activity IEA--
    GO:0052689carboxylic ester hydrolase activity TAS8218228
         
    Find genes that share ontologies with CES1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CES1:
     Decreased circadian period len  Decreased nuclei size in G2M 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CES1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CES1:
    hsa-mir-197-3p (MIRT004206)

    Block miRNA regulation of human, mouse, rat CES1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CES1
    SwitchGear 3'UTR luciferase reporter plasmidCES1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CES1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CES1

    Clone
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    OriGene ORF clones in mouse, rat for CES1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CES1 (NM_001266)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CES1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CES1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EST1_HUMAN, P23141: Endoplasmic reticulum lumen
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    extracellular3
    cytosol2
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen IEA--

    Find genes that share ontologies with CES1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CES1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Irinotecan Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacokinetics0.69
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics0.50
    Irinotecan Pathway0.69
    Irinotecan Pathway, Pharmacodynamics0.50
    2Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    3the visual cycle I (vertebrates)
    retinol biosynthesis0.52
    4Gefitinib Pathway, Pharmacokinetics
    Clopidogrel Pathway, Pharmacokinetics0.43
    5Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with CES1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CES1
        Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)

    4 BioSystems Pathways for CES1
        Fluoropyrimidine Activity
    Irinotecan Pathway
    E2F transcription factor network
    retinol biosynthesis

    5 PharmGKB Pathways for CES1
        Clopidogrel Pathway, Pharmacokinetics
    Fluoropyrimidine Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacodynamics
    Irinotecan Pathway, Pharmacokinetics
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics

    2 Kegg Pathways  (Kegg details for CES1):
        Drug metabolism - other enzymes
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CES1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CES1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for CES1 (P231413 ENSP000003537204) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GUSBP082363, ENSP000003027284I2D: score=2 STRING: ENSP00000302728
    BMPR2Q138733, ENSP000003637084I2D: score=2 STRING: ENSP00000363708
    CREB3O438893I2D: score=1 
    TRIP13Q156453I2D: score=1 
    CES3ENSP000003047824STRING: ENSP00000304782
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process TAS1918003
    GO:0009636response to toxic substance TAS1918003
    GO:0030855epithelial cell differentiation IDA--

    Find genes that share ontologies with CES1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CES1 (EST1)

    Selected HMDB Compounds for CES1 (see all 334)    About this table
    CompoundSynonyms CAS #PubMed Ids
    TG(15:0/16:0/20:2(11Z,14Z))[iso6]Tracylglycerol(15:0/16:0/20:2) (see all 15)--12486725
    TG(15:0/16:0/20:3(8Z,11Z,14Z))[iso6]TAG(15:0/16:0/20:3n6) (see all 16)--12486725
    TG(15:0/16:0/20:4(5Z,8Z,11Z,14Z))[iso6]TAG(15:0/16:0/20:4n6) (see all 15)--12486725
    TG(15:0/18:0/18:2(9Z,12Z))[iso6]TG(15:0/18:0/18:2w6) (see all 15)--12486725
    TG(15:0/18:0/18:3(9Z,12Z,15Z))[iso6]TAG(51:3) (see all 16)--12486725
    TG(15:0/18:1(9Z)/16:0)[iso6]Tracylglycerol(15:0/18:1w9/16:0) (see all 15)--12486725
    TG(15:0/18:1(9Z)/16:1(9Z))[iso6]TG(15:0/18:1/16:1) (see all 15)--12486725
    TG(15:0/18:1(9Z)/18:1(9Z))[iso3]TG(15:0/18:1n9/18:1n9) (see all 15)--12486725
    TG(15:0/18:1(9Z)/18:2(9Z,12Z))[iso6]Tracylglycerol(15:0/18:1/18:2) (see all 15)--12486725
    TG(15:0/18:1(9Z)/18:3(9Z,12Z,15Z))[iso6]Tracylglycerol(15:0/18:1/18:3) (see all 16)--12486725

    Selected DrugBank Compounds for CES1 (see all 25)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Capecitabine-- 154361-50-9enzymesubstrate11291832 12866042 10630095 11587492 11081570
    Alpha-D-Mannose-- 3458-28-4target--17139284 17016423 10592235
    IrinotecanCamptothecin-11 (see all 2)100286-90-6enzymesubstrate19852077 9342501 9726089
    Oseltamivir-- 204255-11-8targetother16966469 19104028 19022936
    Thenoyltrifluoroacetone.alpha.-Thenoyltrifluoroacetone (see all 7)326-91-0target--11992644 10592235
    (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE-- --target--10592235
    (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL-- --target--10592235
    4-Piperidino-Piperidine-- --target--10592235
    BenzocaineEthyl Aminobenzoate (see all 7)94-09-7enzymeinhibitor7470208
    Cholic Acid-- 81-25-4target--10592235

    Selected Novoseek inferred chemical compound relationships for CES1 gene (see all 84)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cl 277082 88.2 3 9500571 (1), 8695654 (1), 11882317 (1)
    4-methylumbelliferyl acetate 83.9 3 9169443 (2), 14581373 (1)
    avasimibe 83.8 10 12360153 (2), 12595916 (2), 15678619 (2), 15533865 (1) (see all 6)
    3-(decyldimethylsilyl)-n-(2-(4-methylphenyl)-1-phenylethyl)propanamide 83.1 3 16835370 (1), 14617686 (1)
    2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)dodecanamide 82.1 5 1675757 (2), 15169972 (1), 7815329 (1)
    cholesteryl oleate 81.9 1 9500571 (1)
    pyripyropene a 81 2 10890154 (1), 9127194 (1)
    diethylumbelliferyl phosphate 80.7 1 7835165 (1)
    cholesterol ester 78.7 20 8025134 (1), 9559268 (1), 11676294 (1), 16962139 (1) (see all 12)
    cholesterol 78.4 323 8185666 (9), 9500571 (6), 7756263 (4), 8695654 (4) (see all 99)

    4 PharmGKB related drug/compound annotations for CES1 gene    About this table
    Drug/compound PharmGKB Annotation
    DabigatranCA  
    clopidogrelCA  
    methylphenidateCA  
    sofosbuvir



    Find genes that share compounds with CES1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CES1 gene (3 alternative transcripts): 
    NM_001025194.1  NM_001025195.1  NM_001266.4  

    Unigene Cluster for CES1:

    Carboxylesterase 1
    Hs.558865  [show with all ESTs]
    Unigene Representative Sequence: NM_001025195
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000565568 ENST00000360526(uc002eil.3) ENST00000422046(uc002eim.3 uc002ein.3)
    ENST00000563241 ENST00000361503 ENST00000569260 ENST00000563005 ENST00000565403
    ENST00000566555
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat CES1

    Additional mRNA sequence: 

    AB025026.1 AB119995.1 AB119996.1 AF177775.1 AK290623.1 AK292209.1 AK301651.1 AY268104.1 
    BC012418.1 BC110338.1 L07764.1 L07765.1 M55509.1 M65261.1 M73499.1 S73751.1 
    X52973.1 

    14 DOTS entries:

    DT.455216  DT.100828227  DT.95133731  DT.99982604  DT.100718449  DT.120708401  DT.92437980  DT.100828223 
    DT.86855737  DT.92437982  DT.97858163  DT.100037180  DT.100828228  DT.95133747 

    Selected AceView cDNA sequences (see all 277):

    AW006490 CD368945 BU741184 CB162528 BQ775275 CB154136 CB110009 BU732288 
    AW138926 BI906521 BM708510 AB119995 BU676203 CA310133 BU678185 AI129284 
    CD369904 CA307528 CA308099 M55509 BI835467 CB164600 AB025026 BI822226 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CES1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGGAGCAAG
    CES1 Expression
    About this image


    CES1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Liver (Hepatobiliary System)
     
     Larynx (Respiratory System)
    CES1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CES1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558865

    UniProtKB/Swiss-Prot: EST1_HUMAN, P23141
    Tissue specificity: Expressed predominantly in liver with lower levels in heart and lung

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CES1: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Cellular Stress Responses in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CES1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ces1g5
    Ces1d1
    carboxylesterase 1G5
    carboxylesterase 1D1
    80.83(n)1
    78.23(a)1
      8 (45.29 cM)5
    1041581  NM_053200.21  NP_444430.21 
     933023695 
    chicken
    (Gallus gallus)
    Aves CES11 carboxylesterase 1 (monocyte/macrophage serine esterase more 59.46(n)
    53.11(a)
      415786  XM_001231969.3  XP_001231970.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC3948972 hypothetical protein LOC394897 70.65(n)    BC064228.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-93f2.11 si:ch211-93f2.1 54.35(n)
    45.72(a)
      561967  XM_001921931.4  XP_001921966.4 


    ENSEMBL Gene Tree for CES1 (if available)
    TreeFam Gene Tree for CES1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CES1 gene
    NLGN12  CES22  ACHE2  CES4A2  NLGN4X2  NLGN4Y2  CES32  NLGN32  
    NLGN22  CEL2  CES5A2  BCHE2  
    12 SIMAP similar genes for CES1 using alignment to 4 protein entries:     EST1_HUMAN (see all proteins):
    CES1P1    CES hBr2    CES8    CES3    CES4A    CES2
    CES5A    NLGN3    ACHE    BCHE    CEL    NLGN1

    Find genes that share paralogs with CES1           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for CES1
    PGOHUM00000262339 PGOHUM00000250685 PGOHUM00000262340


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CES1 (see all 969)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1822893241,2
    C--55840443(+) GGTCTC/TCAGCT 6 -- int10--------
    rs1997990311,2
    C--55840512(+) TGATGC/TGCTCC 6 -- int10--------
    rs2004763291,2
    C--55842116(+) CATAGA/GAGAAA 6 -- int10--------
    rs1996164821,2
    --55842227(+) ACAAT-/CACAA 
            
    CACAA
    6 -- int10--------
    rs2016759361,2
    C--55842238(+) ACAAGC/TCTTCA 6 -- int10--------
    rs1145482981,2
    F--55842361(+) TCTTGT/CTGGTG 3 -- int11Minor allele frequency- C:0.02WA 118
    rs81929501,2
    C,F,H--55842404(-) GATTAA/CAAATT 6 -- int118Minor allele frequency- C:0.34NS EA NA CSA WA 2334
    rs21686101,2
    C,O--55842408(+) TTTAAC/TCTTAG 6 -- int16Minor allele frequency- T:0.41NA WA EA 364
    rs1478561251,2
    --55842465(+) TGGAAG/TGCAAT 3 -- int10--------
    rs1866048951,2
    --55842492(+) AAAGTC/TCTAAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for CES1 (55836763 - 55867249 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CES1 (see all 29):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv471382CNV Duplication19718026
    dgv2867n71CNV Gain21882294
    dgv2868n71CNV Gain21882294
    nsv906706CNV Gain21882294
    dgv2869n71CNV Gain21882294
    dgv479n67CNV Gain20364138
    dgv2862n71CNV Gain21882294
    dgv2863n71CNV Gain21882294
    nsv9446CNV Gain18304495
    esv28619CNV Gain19812545

    Human Gene Mutation Database (HGMD): CES1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CES1
    DNA2.0 Custom Variant and Variant Library Synthesis for CES1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 114835    OMIM disorders: --

    2 diseases for CES1:    
    About MalaCards
    carboxylesterase 1 deficiency    reye syndrome


    Find genes that share disorders with CES1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CES1 gene (see all 18)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atherosclerosis 55.1 30 16518538 (3), 11461099 (2), 12360153 (2), 17885686 (2) (see all 17)
    leydig cell tumor 45.9 2 1332853 (2)
    atherosclerotic plaque 38 1 16971496 (1)
    hypercholesterolemia 29.8 6 10638223 (1), 8953507 (1), 8230120 (1), 7815329 (1) (see all 5)
    coronary atherosclerosis 21.1 1 12360153 (1)
    colon carcinoma 19.7 5 16963839 (2), 17146959 (1), 1639221 (1), 1892896 (1)
    fatty liver 11.7 2 9219899 (1), 12822207 (1)
    necrosis 4.68 2 8920872 (1), 17885686 (1)
    hypertriglyceridemia 0 1 16403839 (1)
    cardiovascular diseases 0 1 12437499 (1)

    Genetic Association Database (GAD): CES1
    Human Genome Epidemiology (HuGE) Navigator: CES1 (12 documents)

    Export disorders for CES1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CES1 gene, integrated from 10 sources (see all 355):
    (articles sorted by number of sources associating them with CES1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis. (PubMed id 18485328)1, 2, 4, 9 Zhu H.-J.... Markowitz J.S. (Am. J. Hum. Genet. 2008)
    2. cDNA cloning and characterization of human monocyte/macrophage serine esterase-1. (PubMed id 2070086)1, 2, 3, 9 Zschunke F....Radzun H.J. (Blood 1991)
    3. Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril. (PubMed id 19185566)1, 7, 9 Zhu H.J....Markowitz J.S. (Biochem. Pharmacol. 2009)
    4. Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA. (PubMed id 11015575)1, 2, 9 Ghosh S. (Physiol. Genomics 2000)
    5. Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene. (PubMed id 15475733)1, 4, 9 Wu M.H....Dolan M.E. (Pharmacogenetics 2004)
    6. Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase. (PubMed id 8049197)1, 2, 9 Becker A.... Schmitz G. (Arterioscler. Thromb. 1994)
    7. Heterologous expression, purification, and characterization of human triacylglycerol hydrolase. (PubMed id 11812220)1, 2, 9 Alam M.... Lehner R. (Protein Expr. Purif. 2002)
    8. Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site. (PubMed id 12022871)1, 2, 9 Alam M.... Lehner R. (Biochemistry 2002)
    9. A single nucleotide polymorphism in the carboxylesterase gene is associated with the responsiveness to imidapril medication and the promoter activity. (PubMed id 16419644)1, 4, 9 Geshi E....Katagiri T. (Hypertens. Res. 2005)
    10. Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine. From binding promiscuity to selective inhibition. (PubMed id 12725862)1, 2, 9 Bencharit S.... Redinbo M.R. (Chem. Biol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1066 HGNC: 1863 AceView: CES1 Ensembl:ENSG00000198848 euGenes: HUgn1066
    ECgene: CES1 Kegg: 1066 H-InvDB: CES1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CES1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CES1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CES1 gene:
    Search GeneIP for patents involving CES1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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