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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CERS6 Gene

protein-coding GIFtS: 49
GCID: GC02P169313

ceramide synthase 6

(Previous names: LAG1 longevity assurance homolog 6 (S. cerevisiae), LAG1...)
(Previous symbol: LASS6)

Explore 3 diseases affiliated with
CERS6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ceramide Synthase 6¹ ²		CERS5²
LASS6¹ ² ³		Longevity Assurance Homolog 6²
LAG1 Homolog, Ceramide Synthase 6¹ ²		CerS5³
LAG1 Longevity Assurance Homolog 6 (S. Cerevisiae)¹		LAG1 Longevity Assurance Homolog 6³

External Ids:	HGNC: 23826¹	Entrez Gene: 253782²	Ensembl: ENSG00000172292⁷	UniProtKB: Q6ZMG9³

Export aliases for CERS6 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CERS6_HUMAN, Q6ZMG9

Function: May be involved in sphingolipid synthesis or its regulation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for CERS6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CERS6 promoter sequence

Search SABiosciences Chromatin IP Primers for CERS6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CERS6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.3 Ensembl cytogenetic band: 2q24.3 HGNC cytogenetic band: 2q31

CERS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CERS6 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P169313: view genomic region (about GC identifiers)

Start:	169,312,372 bp from pter	End:	169,631,644 bp from pter
Size:	319,273 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CERS6_HUMAN, Q6ZMG9 (See protein sequence)

Recommended Name: Ceramide synthase 6

Size: 384 amino acids; 44890 Da

Subcellular location: Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane;

Multi-pass membrane protein (By similarity)

Sequence caution: Sequence=AAH30800.2; Type=Erroneous translation; Note=Wrong choice of frame;

Secondary accessions: Q32M63 Q8N617

Alternative splicing: 2 isoforms: Q6ZMG9-1 Q6ZMG9-2

Explore the universe of human proteins at neXtProt for CERS6: NX_Q6ZMG9

Post-translational modifications:

Glycosylation on Asn-18 is not necessary for function (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6ZMG9

CERS6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001243055.1 NP_982288.1

ENSEMBL proteins:

ENSP00000306579 ENSP00000376453

Reactome Protein details: Q6ZMG9
Human Recombinant Protein Products:

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	Novus Biologicals CERS6 Proteins Novus Biologicals CERS6 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CERS6

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005783	endoplasmic reticulum	--	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0016021	integral to membrane	IEA	--
GO:0031965	nuclear membrane	IEA	--

CERS6 for ontologies About GeneDecksing

CERS6 Antibody Products:

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	Uscn Antibodies for CERS6
	ThermoFisher Antibodies for CERS6

Assay Products for CERS6:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for CERS6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CERS6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CERS6 for domains About GeneDecksing

4 InterPro domains/families:

IPR016439 Longevity_assurance_LAG1_LAC1

IPR001356 Homeodomain

IPR009057 Homeodomain-like

IPR006634 TLC-dom

Graphical View of Domain Structure for InterPro Entry Q6ZMG9

ProtoNet protein and cluster: Q6ZMG9

2 Blocks protein families:

IPB005547 Longevity-assurance protein (LAG1)

IPB006634 TRAM

UniProtKB/Swiss-Prot: CERS6_HUMAN, Q6ZMG9

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CERS6_HUMAN, Q6ZMG9

Function: May be involved in sphingolipid synthesis or its regulation (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: CERS6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CERS6
		8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate CERS6 (see all 80):
		hsa-miR-640 hsa-miR-520e hsa-miR-106a hsa-miR-200a hsa-miR-30d hsa-miR-4275 hsa-miR-3161 hsa-miR-30a

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CERS6 OriGene shRNA RFP: CERS6 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CERS6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CERS6

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CERS6 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CERS6 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for CERS6
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CERS6
		Search LifeMap BioReagents cell lines for CERS6

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS6

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--
GO:0050291	sphingosine N-acyltransferase activity	IEA	--

CERS6 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CERS6:

Lamellipodia and high actin ra

Animal Models:
1 MGI phenotypic allele

for Cers6 (no phenotypes)

CERS6 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sphingolipid metabolism

Sphingolipid metabolism

1.00

Sphingolipid de novo biosynthesis

0.46

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for CERS6

	Sphingolipid metabolism
	Metabolism
	Metabolism of lipids and lipoproteins
	Sphingolipid de novo biosynthesis

CERS6 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CERS6

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for CERS6 (Q6ZMG9³ ENSP00000306579⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MRPL11	Q9Y3B7³	I2D: score=5
SIRT3	ENSP00000372191⁴	STRING: ENSP00000372191
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006665	sphingolipid metabolic process	TAS	--
GO:0030148	sphingolipid biosynthetic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0046513	ceramide biosynthetic process	IEA	--

CERS6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CERS6
Search CenterWatch for drugs/clinical trials and news about CERS6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CERS6 gene (2 alternative transcripts):

NM_001256126.1 NM_203463.2

Unigene Clusters for CERS6:

Ceramide synthase 6

Hs.506829 [show with all ESTs], Hs.743222 [show with all ESTs]

Unigene Representative Sequences: NR_045786, NM_001256126

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000305747(uc002ueb.1) ENST00000392687(uc002uec.1)

miRNA Products:		OriGene 3'-UTR Clone: CERS6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CERS6
		8/80 QIAGEN miScript miRNA Assays for microRNAs that regulate CERS6 (see all 80):
		hsa-miR-640 hsa-miR-520e hsa-miR-106a hsa-miR-200a hsa-miR-30d hsa-miR-4275 hsa-miR-3161 hsa-miR-30a

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CERS6 OriGene shRNA RFP: CERS6 Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CERS6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CERS6 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CERS6 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for CERS6
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CERS6 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CERS6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CERS6

Additional cDNA sequence:

AK023042.1 AK024891.1 AK091391.1 AK172775.1 AL080192.1 BC030800.2 BC109284.1 BC109285.1

9 DOTS entries:

DT.440675 DT.100027737 DT.91754671 DT.100786463 DT.121003426 DT.95254207 DT.121003456 DT.92434231

DT.100702022

14 AceView cDNA sequences:

AI150099 BC035245 BG722671 BQ130079 F00280 BF921625 AA838493 AA394072

BU853076 BI036722 T07901 AW994194 AA292363 BF800177

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CERS6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGGAATAA

About this image

CERS6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CERS6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CERS6

SOURCE GeneReport for Unigene clusters: Hs.506829 Hs.743222

SABiosciences Custom PCR Arrays for CERS6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CERS6 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CERS6

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERS6 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CERS6¹	ceramide synthase 6	76.9(n) 78.74(a)		771503 XM_001233813.2 XP_001233814.2
lizard (Anolis carolinensis)	Reptilia	-- --	--	90(a) 67(a)	1 ↔ many 1 ↔ many	1(245480217-245518172) 1(245388452-245409642)
zebrafish (Danio rerio)	Actinopterygii	LOC564867¹	novel protein similar to LAG1 homolog, ceramide synthase more	72.12(n) 79.95(a)		564867 XM_688191.4 XP_693283.4
fruit fly (Drosophila melanogaster)	Insecta	schlank⁶	schlank	38(a)	possible ortholog	X(6151701-6161260)
worm (Caenorhabditis elegans)	Secernentea	hyl-2⁶ hyl-1⁶	Homolog of Yeast Longevity gene family member (hyl... Homolog of Yeast Longevity gene family member (hyl...	23(a) 22(a)	many ↔ many many ↔ many	X(4697218-4699433) IV(8540541-8544366)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G26200¹	TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing more	45.23(n) 34.36(a)		3766796 NM_001160896.1 NP_001154368.1

ENSEMBL Gene Tree for CERS6 (if available)
TreeFam Gene Tree for CERS6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CERS6 gene

CERS2² CERS4² CERS1² CERS5² CERS3²

5 SIMAP similar genes for CERS6 using alignment to 1 protein entry: CERS6_HUMAN:

CERS5 LASS5 CERS2 CERS3 CERS4

CERS6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186618905^1,2		--	169310789(+)	`AGCATC/GACATT`	2	--	us2k¹		0	--	--	--	--
rs2602566^1,2	F,	--	169310951(-)	`TTCTTC/TTCAGT`	2	--	us2k¹		3		WA NA EA	358
rs189060789^1,2		--	169311031(+)	`CACACA/GACCTG`	2	--	us2k¹		0	--	--	--	--
rs111609434^1,2	F	--	169311341(+)	`CCTGCC/ATGTTG`	2	--	us2k¹		2		CSA	4
rs114863876^1,2	F,	--	169311488(+)	`TTTCAA/GTGCAG`	2	--	us2k¹		1		WA	118
rs148351756^1,2		--	169311498(+)	`GCAGAC/GGAGAC`	2	--	us2k¹		0	--	--	--	--
rs58028670^1,2	C	--	169311632(+)	`ACTCC-/CTCTCTC`	2	--	us2k¹		0	--	--	--	--
rs6433066^1,2	C,F,A,H,	--	169311638(+)	`TCTCTG/CTGTGT`	2	--	us2k¹ trp³		5		NA WA CSA	9
rs72446553^1,2	C,	--	169311639(+)	`CTCTC-/TGTG TGTGT`	2	--	us2k¹		0	--	--	--	--
rs74279797^1,2	C	--	169311664(+)	`GTGTG-/TGCGGTT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CERS6 (169312372 - 169562372 bp, first 250kb of CERS6)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CERS6: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CERS6

DNA2.0 Custom Variant and Variant Library Synthesis for CERS6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CERS6 for disorders About GeneDecksing

3 diseases for CERS6: About MalaCards

rheumatoid arthritis arthritis malaria

Export disorders for CERS6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CERS6 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with CERS6)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Ceramide synthase 6 plays a critical role in the devel opment of experimental autoimmune encephalomyelitis. (PubMed id 22544924)¹ Schiffmann S....Geisslinger G. (2012)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress an d apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network. (PubMed id 22013072)¹ Senkal C.E....Ogretmen B. (2011)
Increased ceramide synthase 2 and 6 mRNA levels in br east cancer tissues and correlation with sphingosine kinase expression. (PubMed id 19912991)¹ Erez-Roman R....Futerman A.H. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human gli oblastoma multiforme cells. (PubMed id 20103619)¹ Yacoub A....Dent P. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 253782	HGNC: 23826	AceView: LASS6.1	Ensembl:ENSG00000172292	euGenes: HUgn253782
ECgene: CERS6	H-InvDB: CERS6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CERS6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CERS6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CERS6 gene:
Search GeneIP for patents involving CERS6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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CERS6 Gene

ceramide synthase 6

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CERS6 Gene

ceramide synthase 6

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Intellectual Property
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