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Aliases for CERS6 Gene

Aliases for CERS6 Gene

  • Ceramide Synthase 6 2 3 5
  • LAG1 Homolog, Ceramide Synthase 6 2 3
  • LASS6 3 4
  • LAG1 Longevity Assurance Homolog 6 (S. Cerevisiae) 2
  • LAG1 Longevity Assurance Homolog 6 4
  • Longevity Assurance Homolog 6 3
  • CerS5 3
  • CerS6 4

External Ids for CERS6 Gene

Previous HGNC Symbols for CERS6 Gene

  • LASS6

Previous GeneCards Identifiers for CERS6 Gene

  • GC02P169313

Summaries for CERS6 Gene

GeneCards Summary for CERS6 Gene

CERS6 (Ceramide Synthase 6) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. GO annotations related to this gene include sphingosine N-acyltransferase activity. An important paralog of this gene is CERS5.

UniProtKB/Swiss-Prot for CERS6 Gene

  • May be involved in sphingolipid synthesis or its regulation.

Additional gene information for CERS6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERS6 Gene

Genomics for CERS6 Gene

Regulatory Elements for CERS6 Gene

Enhancers for CERS6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H168545 1 Ensembl ENCODE dbSUPER 16.8 +90.0 89981 1 CTBP1 CREB1 FOS NR3C1 WT1 CERS6 GC02M168537 MIR4774
GH02H168582 1.2 Ensembl ENCODE dbSUPER 11.3 +128.2 128248 2 PKNOX1 MAFG ZEB1 ZSCAN21 JUND ZNF692 SCRT2 NFE2 PRDM10 RUNX3 RNU6-766P CERS6 MIR4774 GC02M168607
GH02H168432 0.8 ENCODE dbSUPER 16.8 -22.7 -22740 1 PKNOX1 GATA3 IKZF1 RUNX3 BATF CERS6 GC02M168440 LOC105373734
GH02H168521 1.2 Ensembl ENCODE dbSUPER 10.9 +65.7 65735 1 HDAC1 SMARCE1 MAZ KLF1 SOX6 NRF1 CEBPG NFIC CTBP1 JUND CERS6 GC02M168537 GC02M168480
GH02H168476 0.9 dbSUPER 12.4 +21.5 21479 2 ELF3 ARID4B RAD21 RARA YY1 MXD4 REST MIER2 NR2F2 NFIL3 CERS6 GC02M168444 GC02M168480
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CERS6 on UCSC Golden Path with GeneCards custom track

Promoters for CERS6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000125886 1138 2801 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF143

Genomic Location for CERS6 Gene

Chromosome:
2
Start:
168,455,862 bp from pter
End:
168,775,137 bp from pter
Size:
319,276 bases
Orientation:
Plus strand

Genomic View for CERS6 Gene

Genes around CERS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERS6 Gene

Proteins for CERS6 Gene

  • Protein details for CERS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMG9-CERS6_HUMAN
    Recommended name:
    Ceramide synthase 6
    Protein Accession:
    Q6ZMG9
    Secondary Accessions:
    • Q32M63
    • Q8N617

    Protein attributes for CERS6 Gene

    Size:
    384 amino acids
    Molecular mass:
    44890 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30800.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for CERS6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CERS6 Gene

Post-translational modifications for CERS6 Gene

Other Protein References for CERS6 Gene

No data available for DME Specific Peptides for CERS6 Gene

Domains & Families for CERS6 Gene

Gene Families for CERS6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for CERS6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CERS6: view

No data available for UniProtKB/Swiss-Prot for CERS6 Gene

Function for CERS6 Gene

Molecular function for CERS6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in sphingolipid synthesis or its regulation.

Phenotypes From GWAS Catalog for CERS6 Gene

Gene Ontology (GO) - Molecular Function for CERS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0050291 sphingosine N-acyltransferase activity TAS --
genes like me logo Genes that share ontologies with CERS6: view
genes like me logo Genes that share phenotypes with CERS6: view

Animal Models for CERS6 Gene

MGI Knock Outs for CERS6:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CERS6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CERS6 Gene

Localization for CERS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERS6 Gene

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CERS6 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
nucleus 3
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CERS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CERS6: view

Pathways & Interactions for CERS6 Gene

genes like me logo Genes that share pathways with CERS6: view

Pathways by source for CERS6 Gene

Gene Ontology (GO) - Biological Process for CERS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0046513 ceramide biosynthetic process IBA --
genes like me logo Genes that share ontologies with CERS6: view

No data available for SIGNOR curated interactions for CERS6 Gene

Drugs & Compounds for CERS6 Gene

(4) Drugs for CERS6 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
sphinganine Pharma 0
Coenzyme A Nutra 0
genes like me logo Genes that share compounds with CERS6: view

Transcripts for CERS6 Gene

Unigene Clusters for CERS6 Gene

Ceramide synthase 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CERS6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CERS6 Gene

No ASD Table

Relevant External Links for CERS6 Gene

GeneLoc Exon Structure for
CERS6
ECgene alternative splicing isoforms for
CERS6

Expression for CERS6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CERS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CERS6 Gene

This gene is overexpressed in Lung (15.4), Fetal Brain (10.7), Testis (9.7), and Fetal gut (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CERS6 Gene



Protein tissue co-expression partners for CERS6 Gene

NURSA nuclear receptor signaling pathways regulating expression of CERS6 Gene:

CERS6

SOURCE GeneReport for Unigene cluster for CERS6 Gene:

Hs.506829

Evidence on tissue expression from TISSUES for CERS6 Gene

  • Intestine(4.4)
  • Liver(4.3)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with CERS6: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CERS6 Gene

Orthologs for CERS6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CERS6 34
  • 100 (a)
OneToOne
LASS6 33
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia CERS6 33 34
  • 93.8 (n)
cow
(Bos Taurus)
Mammalia CERS6 33 34
  • 93.14 (n)
mouse
(Mus musculus)
Mammalia Cers6 33 16 34
  • 90.28 (n)
rat
(Rattus norvegicus)
Mammalia Cers6 33
  • 90.19 (n)
oppossum
(Monodelphis domestica)
Mammalia CERS6 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CERS6 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CERS6 33 34
  • 77.5 (n)
lizard
(Anolis carolinensis)
Reptilia CERS6 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cers6 33
  • 77.35 (n)
zebrafish
(Danio rerio)
Actinopterygii cers6 33 34
  • 72.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta schlank 34
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hyl-1 34
  • 27 (a)
ManyToMany
hyl-2 34
  • 26 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G26200 33
  • 45.66 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9504 34
  • 44 (a)
OneToMany
Species where no ortholog for CERS6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERS6 Gene

ENSEMBL:
Gene Tree for CERS6 (if available)
TreeFam:
Gene Tree for CERS6 (if available)

Paralogs for CERS6 Gene

Paralogs for CERS6 Gene

(5) SIMAP similar genes for CERS6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CERS6: view

Variants for CERS6 Gene

Sequence variations from dbSNP and Humsavar for CERS6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000001760 -- 168,586,457(+) AGTAT(A/G)TATAA intron-variant
rs1000010841 -- 168,627,448(+) TATTC(C/T)TCTGC intron-variant
rs1000020918 -- 168,684,578(+) TTCAA(A/T)ATTTA intron-variant, utr-variant-5-prime
rs1000022069 -- 168,731,976(+) ATTAA(G/T)TCTAC intron-variant
rs1000043957 -- 168,597,588(+) TAACC(A/G)TAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CERS6 Gene

Variant ID Type Subtype PubMed ID
dgv2088n106 CNV deletion 24896259
dgv64n68 CNV gain 17160897
esv1631379 CNV deletion 17803354
esv1682076 CNV deletion 17803354
esv1983529 CNV deletion 18987734
esv2350302 CNV deletion 18987734
esv2428031 CNV deletion 19546169
esv2567946 CNV deletion 19546169
esv2663091 CNV deletion 23128226
esv2667449 CNV deletion 23128226
esv2721102 CNV deletion 23290073
esv2721103 CNV deletion 23290073
esv2721104 CNV deletion 23290073
esv2721105 CNV deletion 23290073
esv2721107 CNV deletion 23290073
esv2721108 CNV deletion 23290073
esv3022022 CNV deletion 24192839
esv3263 CNV loss 18987735
esv3304185 CNV mobile element insertion 20981092
esv3391091 CNV insertion 20981092
esv3440550 CNV insertion 20981092
esv3560503 CNV deletion 23714750
esv3560507 CNV deletion 23714750
esv3593311 CNV loss 21293372
esv3593313 CNV loss 21293372
esv3593314 CNV loss 21293372
esv3593317 CNV loss 21293372
esv4907 CNV loss 18987735
esv6815 CNV loss 19470904
esv999398 CNV deletion 20482838
nsv1072042 CNV deletion 25765185
nsv1114148 CNV deletion 24896259
nsv215317 CNV deletion 16902084
nsv428405 CNV loss 18775914
nsv473657 CNV novel sequence insertion 20440878
nsv475427 CNV novel sequence insertion 20440878
nsv821785 CNV loss 20364138
nsv834450 CNV gain 17160897
nsv954725 CNV deletion 24416366

Variation tolerance for CERS6 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 43.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CERS6 Gene

Human Gene Mutation Database (HGMD)
CERS6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CERS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERS6 Gene

Disorders for CERS6 Gene

Relevant External Links for CERS6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CERS6

No disorders were found for CERS6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CERS6 Gene

Publications for CERS6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner. (PMID: 26783755) Fekry B … Krupenko NI (PloS one 2016) 3 60
  5. Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells. (PMID: 26650179) Suzuki M … Takahashi T (The Journal of clinical investigation 2016) 3 60

Products for CERS6 Gene

Sources for CERS6 Gene

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