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Aliases for CERS6 Gene

Aliases for CERS6 Gene

  • Ceramide Synthase 6 2 3 5
  • LAG1 Homolog, Ceramide Synthase 6 2 3
  • LASS6 3 4
  • LAG1 Longevity Assurance Homolog 6 (S. Cerevisiae) 2
  • LAG1 Longevity Assurance Homolog 6 4
  • Longevity Assurance Homolog 6 3
  • CerS5 3
  • CerS6 4

External Ids for CERS6 Gene

Previous HGNC Symbols for CERS6 Gene

  • LASS6

Previous GeneCards Identifiers for CERS6 Gene

  • GC02P169313

Summaries for CERS6 Gene

GeneCards Summary for CERS6 Gene

CERS6 (Ceramide Synthase 6) is a Protein Coding gene. Among its related pathways are Sphingolipid signaling pathway and Metabolism. GO annotations related to this gene include sphingosine N-acyltransferase activity. An important paralog of this gene is CERS5.

UniProtKB/Swiss-Prot for CERS6 Gene

  • May be involved in sphingolipid synthesis or its regulation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERS6 Gene

Genomics for CERS6 Gene

Regulatory Elements for CERS6 Gene

Enhancers for CERS6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CERS6 on UCSC Golden Path with GeneCards custom track

Promoters for CERS6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CERS6 on UCSC Golden Path with GeneCards custom track

Genomic Location for CERS6 Gene

168,455,862 bp from pter
168,775,137 bp from pter
319,276 bases
Plus strand

Genomic View for CERS6 Gene

Genes around CERS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERS6 Gene

Proteins for CERS6 Gene

  • Protein details for CERS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ceramide synthase 6
    Protein Accession:
    Secondary Accessions:
    • Q32M63
    • Q8N617

    Protein attributes for CERS6 Gene

    384 amino acids
    Molecular mass:
    44890 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH30800.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for CERS6 Gene


neXtProt entry for CERS6 Gene

Proteomics data for CERS6 Gene at MOPED

Post-translational modifications for CERS6 Gene

Other Protein References for CERS6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CERS6 Gene

Domains & Families for CERS6 Gene

Gene Families for CERS6 Gene

Suggested Antigen Peptide Sequences for CERS6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
genes like me logo Genes that share domains with CERS6: view

Function for CERS6 Gene

Molecular function for CERS6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in sphingolipid synthesis or its regulation.
genes like me logo Genes that share phenotypes with CERS6: view

Animal Models for CERS6 Gene

MGI Knock Outs for CERS6:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CERS6 Gene

Localization for CERS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERS6 Gene

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CERS6 Gene COMPARTMENTS Subcellular localization image for CERS6 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
cytosol 3
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CERS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
genes like me logo Genes that share ontologies with CERS6: view

Pathways & Interactions for CERS6 Gene

genes like me logo Genes that share pathways with CERS6: view

Pathways by source for CERS6 Gene

Interacting Proteins for CERS6 Gene

Gene Ontology (GO) - Biological Process for CERS6 Gene


No data available for SIGNOR curated interactions for CERS6 Gene

Drugs & Compounds for CERS6 Gene

(3) Drugs for CERS6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Coenzyme A Nutra 0
genes like me logo Genes that share compounds with CERS6: view

Transcripts for CERS6 Gene

mRNA/cDNA for CERS6 Gene

(3) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CERS6 Gene

Ceramide synthase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CERS6 Gene

No ASD Table

Relevant External Links for CERS6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CERS6 Gene

mRNA expression in normal human tissues for CERS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CERS6 Gene

This gene is overexpressed in Lung (15.4), Fetal Brain (10.7), Testis (9.7), and Fetal gut (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CERS6 Gene

SOURCE GeneReport for Unigene cluster for CERS6 Gene Hs.506829

genes like me logo Genes that share expression patterns with CERS6: view

Protein tissue co-expression partners for CERS6 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CERS6 Gene

Orthologs for CERS6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERS6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CERS6 35
  • 93.14 (n)
  • 93.49 (a)
CERS6 36
  • 93 (a)
(Canis familiaris)
Mammalia CERS6 35
  • 93.8 (n)
  • 95.81 (a)
CERS6 36
  • 96 (a)
(Mus musculus)
Mammalia Cers6 35
  • 90.28 (n)
  • 95.31 (a)
Cers6 16
Cers6 36
  • 95 (a)
(Pan troglodytes)
Mammalia LASS6 35
  • 99.74 (n)
  • 100 (a)
CERS6 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cers6 35
  • 90.19 (n)
  • 95.31 (a)
(Monodelphis domestica)
Mammalia CERS6 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia CERS6 36
  • 81 (a)
(Gallus gallus)
Aves CERS6 35
  • 77.5 (n)
  • 79.72 (a)
CERS6 36
  • 78 (a)
(Anolis carolinensis)
Reptilia CERS6 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cers6 35
  • 77.35 (n)
  • 83.53 (a)
(Danio rerio)
Actinopterygii cers6 35
  • 72.96 (n)
  • 81.11 (a)
cers6 36
  • 79 (a)
fruit fly
(Drosophila melanogaster)
Insecta schlank 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea hyl-1 36
  • 27 (a)
hyl-2 36
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G26200 35
  • 45.66 (n)
  • 32.88 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9504 36
  • 44 (a)
Species with no ortholog for CERS6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERS6 Gene

Gene Tree for CERS6 (if available)
Gene Tree for CERS6 (if available)

Paralogs for CERS6 Gene

Paralogs for CERS6 Gene

(5) SIMAP similar genes for CERS6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CERS6: view

Variants for CERS6 Gene

Sequence variations from dbSNP and Humsavar for CERS6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs716335 -- 168,545,617(-) ATTCT(C/T)TGTGT intron-variant
rs717037 -- 168,565,096(-) TAAAA(C/T)TGTCA intron-variant
rs717038 -- 168,565,045(-) TATGC(C/G/T)AAGGC intron-variant
rs717039 -- 168,564,783(-) ATGCA(G/T)GGGTA intron-variant
rs719970 -- 168,591,521(+) CACAA(C/T)CATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CERS6 Gene

Variant ID Type Subtype PubMed ID
nsv428405 CNV Loss 18775914
nsv834450 CNV Gain 17160897
esv2667449 CNV Deletion 23128226
esv2721102 CNV Deletion 23290073
dgv64n68 CNV Gain 17160897
esv2567946 CNV Deletion 19546169
esv2350302 CNV Deletion 18987734
esv3263 CNV Deletion 18987735
esv2721103 CNV Deletion 23290073
esv999398 CNV Deletion 20482838
esv6815 CNV Loss 19470904
esv2428031 CNV Deletion 19546169
esv1682076 CNV Deletion 17803354
esv2721104 CNV Deletion 23290073
esv268464 CNV Insertion 20981092
esv2663091 CNV Deletion 23128226
esv2721105 CNV Deletion 23290073
nsv821785 CNV Loss 20364138
esv2721107 CNV Deletion 23290073
esv1983529 CNV Deletion 18987734
esv4907 CNV Deletion 18987735
esv2721108 CNV Deletion 23290073
nsv215317 CNV Loss 16902084
esv1631379 CNV Deletion 17803354

Variation tolerance for CERS6 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 43.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CERS6 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERS6 Gene

Disorders for CERS6 Gene

Relevant External Links for CERS6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CERS6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CERS6 Gene

Publications for CERS6 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility. (PMID: 24632610) Edmond V. … Legembre P. (Oncogene 2015) 3
  3. Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6. (PMID: 25766330) SchA1ll S. … Kashkar H. (Cell Death Dis 2015) 3
  4. Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner. (PMID: 25839235) Tirodkar T.S. … Voelkel-Johnson C. (J. Biol. Chem. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CERS6 Gene

Sources for CERS6 Gene