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CERS6 Gene(Protein Coding)

Ceramide Synthase 6

GCID:
GC02P168455
GIFtS:
50
Genes Participants
UDN Logo

Aliases for CERS6 Gene

Aliases for CERS6 Gene

  • Ceramide Synthase 6 2 3 5
  • LAG1 Homolog, Ceramide Synthase 6 2 3
  • LASS6 3 4
  • LAG1 Longevity Assurance Homolog 6 (S. Cerevisiae) 2
  • LAG1 Longevity Assurance Homolog 6 4
  • Longevity Assurance Homolog 6 3
  • CerS5 3
  • CerS6 4

External Ids for CERS6 Gene

Previous HGNC Symbols for CERS6 Gene

  • LASS6

Previous GeneCards Identifiers for CERS6 Gene

  • GC02P169313

Summaries for CERS6 Gene

GeneCards Summary for CERS6 Gene

CERS6 (Ceramide Synthase 6) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Sphingolipid signaling pathway. GO annotations related to this gene include sphingosine N-acyltransferase activity. An important paralog of this gene is CERS5.

UniProtKB/Swiss-Prot for CERS6 Gene

  • May be involved in sphingolipid synthesis or its regulation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERS6 Gene

Genomics for CERS6 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CERS6 Gene

Enhancers for CERS6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G168545 1.1 Ensembl ENCODE dbSUPER 16.8 +90.0 89981 1.4 ZNF263 CTBP1 CREB1 FOS NR3C1 WT1 CERS6 GC02M168537 MIR4774
GH02G168582 1.2 Ensembl ENCODE dbSUPER 11.3 +128.2 128248 2.6 PKNOX1 ZEB1 SCRT2 NFE2 PRDM10 NFE2L2 NR2F1 USF2 MAFG ZNF354B RNU6-766P CERS6 MIR4774 GC02M168607
GH02G168432 0.8 ENCODE dbSUPER 16.8 -22.7 -22740 1.5 PKNOX1 GATA3 IKZF1 TCF7 EP300 CERS6 GC02M168440 LOC105373734
GH02G168521 1.2 Ensembl ENCODE dbSUPER 10.9 +65.7 65735 1.2 HDAC1 SMARCE1 MAZ KLF1 NRF1 CEBPG ARID1B NFIC CBX8 JUND CERS6 GC02M168537 GC02M168480
GH02G168703 0.8 ENCODE 15.1 +250.0 250048 5.4 BCOR CTCF ARNT CHD4 EBF1 RAD21 ZBTB40 SMC3 SMARCA5 ZNF654 CERS6 NOSTRIN RNU6-766P GC02M168607
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CERS6 on UCSC Golden Path with GeneCards custom track

Promoters for CERS6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000125886 1138 2801 HNRNPUL1 PKNOX1 MLX CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B

Genomic Location for CERS6 Gene

Chromosome:
2
Start:
168,455,862 bp from pter
End:
168,775,137 bp from pter
Size:
319,276 bases
Orientation:
Plus strand

Genomic View for CERS6 Gene

Genes around CERS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERS6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CERS6 Gene

Proteins for CERS6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CERS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMG9-CERS6_HUMAN
    Recommended name:
    Ceramide synthase 6
    Protein Accession:
    Q6ZMG9
    Secondary Accessions:
    • Q32M63
    • Q8N617

    Protein attributes for CERS6 Gene

    Size:
    384 amino acids
    Molecular mass:
    44890 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH30800.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Alternative splice isoforms for CERS6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CERS6 Gene

Protein Expression for CERS6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CERS6 Gene

Other Protein References for CERS6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CERS6 Gene

Domains & Families for CERS6 Gene

Gene Families for CERS6 Gene

HGNC:

Protein Domains for CERS6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CERS6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CERS6: view

No data available for UniProtKB/Swiss-Prot for CERS6 Gene

Function for CERS6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CERS6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in sphingolipid synthesis or its regulation.

Gene Ontology (GO) - Molecular Function for CERS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0050291 sphingosine N-acyltransferase activity TAS --
genes like me logo Genes that share ontologies with CERS6: view
genes like me logo Genes that share phenotypes with CERS6: view

Animal Models for CERS6 Gene

MGI Knock Outs for CERS6:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CERS6 Gene

Localization for CERS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERS6 Gene

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CERS6 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CERS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CERS6: view

Pathways & Interactions for CERS6 Gene

genes like me logo Genes that share pathways with CERS6: view

Pathways by source for CERS6 Gene

1 BioSystems pathway for CERS6 Gene

Gene Ontology (GO) - Biological Process for CERS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0046513 ceramide biosynthetic process IBA,IEA --
genes like me logo Genes that share ontologies with CERS6: view

No data available for SIGNOR curated interactions for CERS6 Gene

Drugs & Compounds for CERS6 Gene

Products:

  1. Drug

(4) Drugs for CERS6 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0
sphinganine Pharma 0
Coenzyme A Nutra 0
genes like me logo Genes that share compounds with CERS6: view

Transcripts for CERS6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CERS6 Gene

(4) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(259) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CERS6 Gene

Ceramide synthase 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CERS6 Gene

No ASD Table

Relevant External Links for CERS6 Gene

GeneLoc Exon Structure for
CERS6
ECgene alternative splicing isoforms for
CERS6

Expression for CERS6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CERS6 Gene

mRNA expression in normal human tissues for CERS6 Gene
mRNA expression by BioGPS for CERS6 GenemRNA expression by GTEx for CERS6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CERS6 Gene

This gene is overexpressed in Lung (15.4), Fetal Brain (10.7), Testis (9.7), and Fetal gut (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CERS6 Gene



Protein tissue co-expression partners for CERS6 Gene

NURSA nuclear receptor signaling pathways regulating expression of CERS6 Gene:

CERS6

SOURCE GeneReport for Unigene cluster for CERS6 Gene:

Hs.506829

Evidence on tissue expression from TISSUES for CERS6 Gene

  • Intestine(4.4)
  • Liver(4.2)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with CERS6: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CERS6 Gene

Orthologs for CERS6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CERS6 35
  • 100 (a)
 OneToOne
LASS6 34
  • 99.74 (n)
dog
(Canis familiaris)
 Mammalia CERS6 34 35
  • 93.8 (n)
cow
(Bos Taurus)
 Mammalia CERS6 34 35
  • 93.14 (n)
mouse
(Mus musculus)
 Mammalia Cers6 34 16 35
  • 90.28 (n)
rat
(Rattus norvegicus)
 Mammalia Cers6 34
  • 90.19 (n)
oppossum
(Monodelphis domestica)
 Mammalia CERS6 35
  • 89 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CERS6 35
  • 81 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves CERS6 34 35
  • 77.5 (n)
lizard
(Anolis carolinensis)
 Reptilia CERS6 35
  • 76 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia cers6 34
  • 77.35 (n)
zebrafish
(Danio rerio)
 Actinopterygii cers6 34 35
  • 72.96 (n)
fruit fly
(Drosophila melanogaster)
 Insecta schlank 35
  • 39 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea hyl-1 35
  • 27 (a)
 ManyToMany
hyl-2 35
  • 26 (a)
 ManyToMany
thale cress
(Arabidopsis thaliana)
 eudicotyledons AT1G26200 34
  • 45.66 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.9504 35
  • 44 (a)
 OneToMany
Species where no ortholog for CERS6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERS6 Gene

ENSEMBL:
Gene Tree for CERS6 (if available)
TreeFam:
Gene Tree for CERS6 (if available)

Paralogs for CERS6 Gene

Paralogs for CERS6 Gene

(5) SIMAP similar genes for CERS6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CERS6: view

Variants for CERS6 Gene

Sequence variations from dbSNP and Humsavar for CERS6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000001760 -- 168,586,457(+) AGTAT(A/G)TATAA intron-variant
rs1000010841 -- 168,627,448(+) TATTC(C/T)TCTGC intron-variant
rs1000020918 -- 168,684,578(+) TTCAA(A/T)ATTTA intron-variant, utr-variant-5-prime
rs1000022069 -- 168,731,976(+) ATTAA(G/T)TCTAC intron-variant
rs1000043957 -- 168,597,588(+) TAACC(A/G)TAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CERS6 Gene

Variant ID Type Subtype PubMed ID
dgv2088n106 CNV deletion 24896259
dgv64n68 CNV gain 17160897
esv1631379 CNV deletion 17803354
esv1682076 CNV deletion 17803354
esv1983529 CNV deletion 18987734
esv2350302 CNV deletion 18987734
esv2428031 CNV deletion 19546169
esv2567946 CNV deletion 19546169
esv2663091 CNV deletion 23128226
esv2667449 CNV deletion 23128226
esv2721102 CNV deletion 23290073
esv2721103 CNV deletion 23290073
esv2721104 CNV deletion 23290073
esv2721105 CNV deletion 23290073
esv2721107 CNV deletion 23290073
esv2721108 CNV deletion 23290073
esv3022022 CNV deletion 24192839
esv3263 CNV loss 18987735
esv3304185 CNV mobile element insertion 20981092
esv3391091 CNV insertion 20981092
esv3440550 CNV insertion 20981092
esv3560503 CNV deletion 23714750
esv3560507 CNV deletion 23714750
esv3593311 CNV loss 21293372
esv3593313 CNV loss 21293372
esv3593314 CNV loss 21293372
esv3593317 CNV loss 21293372
esv4907 CNV loss 18987735
esv6815 CNV loss 19470904
esv999398 CNV deletion 20482838
nsv1072042 CNV deletion 25765185
nsv1114148 CNV deletion 24896259
nsv215317 CNV deletion 16902084
nsv428405 CNV loss 18775914
nsv473657 CNV novel sequence insertion 20440878
nsv475427 CNV novel sequence insertion 20440878
nsv821785 CNV loss 20364138
nsv834450 CNV gain 17160897
nsv954725 CNV deletion 24416366

Variation tolerance for CERS6 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 43.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CERS6 Gene

Human Gene Mutation Database (HGMD)
CERS6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CERS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERS6 Gene

Disorders for CERS6 Gene

Relevant External Links for CERS6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CERS6

No disorders were found for CERS6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CERS6 Gene

Publications for CERS6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells. (PMID: 26650179) Suzuki M. … Takahashi T. (J. Clin. Invest. 2016) 3 64
  4. Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner. (PMID: 26783755) Fekry B. … Krupenko N.I. (PLoS ONE 2016) 3 64
  5. CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress. (PMID: 27302066) Fekry B. … Krupenko N.I. (J. Biol. Chem. 2016) 3 64

Products for CERS6 Gene

Sources for CERS6 Gene

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