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CERS6 Gene

protein-coding   GIFtS: 50
GCID: GC02P169313

Ceramide Synthase 6

(Previous names: LAG1 longevity assurance homolog 6 (S. cerevisiae), LAG1...)
(Previous symbol: LASS6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ceramide Synthase 61 2     CERS52
LASS61 2 3 5     Longevity Assurance Homolog 62
LAG1 Homolog, Ceramide Synthase 61 2     CerS63
LAG1 Longevity Assurance Homolog 6 (S. Cerevisiae)1     LAG1 Longevity Assurance Homolog 63

External Ids:    HGNC: 238261   Entrez Gene: 2537822   Ensembl: ENSG000001722927   OMIM: 6153365   UniProtKB: Q6ZMG93   

Export aliases for CERS6 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CERS6 Gene:
CERS6 (ceramide synthase 6) is a protein-coding gene. GO annotations related to this gene include sphingosine N-acyltransferase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CERS2.

UniProtKB/Swiss-Prot: CERS6_HUMAN, Q6ZMG9
Function: May be involved in sphingolipid synthesis or its regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CERS6
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCERS6 promoter sequence
   Search Chromatin IP Primers for CERS6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CERS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.3   Ensembl cytogenetic band:  2q24.3   HGNC cytogenetic band: 2q31

CERS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CERS6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P169313:  view genomic region     (about GC identifiers)

Start:
169,312,372 bp from pter      End:
169,631,644 bp from pter
Size:
319,273 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CERS6_HUMAN, Q6ZMG9 (See protein sequence)
Recommended Name: Ceramide synthase 6  
Size: 384 amino acids; 44890 Da
Sequence caution: Sequence=AAH30800.2; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: Q32M63 Q8N617
Alternative splicing: 2 isoforms:  Q6ZMG9-1   Q6ZMG9-2   

Explore the universe of human proteins at neXtProt for CERS6: NX_Q6ZMG9

Explore proteomics data for CERS6 at MOPED

Post-translational modifications: 

  • Glycosylation on Asn-18 is not necessary for function (By similarity)1
  • Ubiquitination2 at Lys104
  • Glycosylation2 at Asn18
  • Modification sites at PhosphoSitePlus

  • See CERS6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001243055.1  NP_982288.1  

    ENSEMBL proteins: 
     ENSP00000306579   ENSP00000376453  
    Reactome Protein details: Q6ZMG9

    CERS6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals CERS6 Proteins
    Novus Biologicals CERS6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CERS6 

     
    antibodies-online proteins for CERS6 (4 products) 

     
    antibodies-online peptides for CERS6

    CERS6 Antibody Products:

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    ThermoFisher Antibodies for CERS6
    antibodies-online antibodies for CERS6 (50 products) 

    CERS6 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CERS6 
    antibodies-online kits for CERS6 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CERS: Homeoboxes / CERS class

    4 InterPro protein domains:
     IPR016439 Longevity_assurance_LAG1_LAC1
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like
     IPR006634 TLC-dom

    Graphical View of Domain Structure for InterPro Entry Q6ZMG9

    ProtoNet protein and cluster: Q6ZMG9

    2 Blocks protein domains:
    IPB005547 Longevity-assurance protein (LAG1)
    IPB006634 TRAM


    UniProtKB/Swiss-Prot: CERS6_HUMAN, Q6ZMG9
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain


    Find genes that share domains with CERS6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CERS6_HUMAN, Q6ZMG9
    Function: May be involved in sphingolipid synthesis or its regulation (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0050291sphingosine N-acyltransferase activity IEA--
         
    Find genes that share ontologies with CERS6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CERS6:
     Lamellipodia and high actin ra 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cers6):
     behavior/neurological  hematopoietic system  homeostasis/metabolism  immune system  nervous system 

    Find genes that share phenotypes with CERS6           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CERS6

    miRNA
    Products:
        
    miRTarBase miRNAs that target CERS6:
    hsa-mir-192-5p (MIRT026363), hsa-mir-21-5p (MIRT030725)

    Block miRNA regulation of human, mouse, rat CERS6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CERS6 (see all 80):
    hsa-miR-640 hsa-miR-520e hsa-miR-106a hsa-miR-200a hsa-miR-30d hsa-miR-4275 hsa-miR-3161 hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CERS6
    Predesigned siRNA for gene silencing in human, mouse, rat CERS6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CERS6

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CERS6
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS6

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CERS6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CERS6_HUMAN, Q6ZMG9: Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane;
    Multi-pass membrane protein (By similarity)

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0031965nuclear membrane IEA--

    Find genes that share ontologies with CERS6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CERS6 About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Sphingolipid de novo biosynthesis0.46
    Sphingolipid metabolism0.61
    Sphingolipid Metabolism0.42
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38


    Find genes that share SuperPaths with CERS6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CERS6
        Sphingolipid Metabolism

    1 Reactome Pathway for CERS6
        Sphingolipid de novo biosynthesis


    2 Kegg Pathways  (Kegg details for CERS6):
        Sphingolipid metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CERS6
    Interactions:

        Search GeneGlobe Interaction Network for CERS6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    Selected Interacting proteins for CERS6 (Q6ZMG93 ENSP000003065794) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MRPL11Q9Y3B73I2D: score=5 
    ACER2ENSP000003426094STRING: ENSP00000342609
    SEC62ENSP000003376884STRING: ENSP00000337688
    SIRT3ENSP000003721914STRING: ENSP00000372191
    ACER3ENSP000002785444STRING: ENSP00000278544
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006665sphingolipid metabolic process TAS--
    GO:0030148sphingolipid biosynthetic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046513ceramide biosynthetic process IEA--

    Find genes that share ontologies with CERS6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CERS6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CERS6 gene (2 alternative transcripts): 
    NM_001256126.1  NM_203463.2  

    Unigene Cluster for CERS6:

    Ceramide synthase 6
    Hs.506829  [show with all ESTs]
    Unigene Representative Sequence: NR_045786
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305747(uc002ueb.1) ENST00000392687(uc002uec.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CERS6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CERS6 (see all 80):
    hsa-miR-640 hsa-miR-520e hsa-miR-106a hsa-miR-200a hsa-miR-30d hsa-miR-4275 hsa-miR-3161 hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CERS6
    Predesigned siRNA for gene silencing in human, mouse, rat CERS6
    Clone
    Products:
         
    OriGene clones in human, mouse for CERS6 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CERS6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CERS6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CERS6
      QuantiTect SYBR Green Assays in human, mouse, rat CERS6
      QuantiFast Probe-based Assays in human, mouse, rat CERS6

    Additional mRNA sequence: 

    AK123214.1 BC035245.1 NR_045786.1 NR_045787.1 U52135.1 

    5 DOTS entries:

    DT.440675  DT.100027737  DT.121003426  DT.95254207  DT.100702022 

    14 AceView cDNA sequences:

    BC035245 AI150099 BI036722 AA838493 BG722671 BU853076 BF921625 AA394072 
    F00280 BQ130079 AW994194 AA292363 T07901 BF800177 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CERS6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGGAATAA
    CERS6 Expression
    About this image


    CERS6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
    CERS6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CERS6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.506829
        Custom PCR Arrays for CERS6
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CERS6 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cers61 , 5 LAG1 homolog, ceramide synthase 65
    ceramide synthase 61
    90.28(n)1
    95.31(a)1
      2 (39.53 cM)5
    2414471  NM_172856.31  NP_766444.11 
     688614415 
    chicken
    (Gallus gallus)
    Aves CERS61 ceramide synthase 6 77.5(n)
    79.72(a)
      771503  XM_004942776.1  XP_004942833.1 
    lizard
    (Anolis carolinensis)
    Reptilia CERS66
    ceramide synthase 6
    76(a)
    1 ↔ 1
    1(245388446-245518415)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cers61 ceramide synthase 6 77.35(n)
    83.53(a)
      100489264  XM_004917706.1  XP_004917763.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cers61 ceramide synthase 6 72.96(n)
    81.11(a)
      564867  XM_688191.5  XP_693283.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta schlank6
    schlank
    39(a)
    1 → many
    X(6151701-6161260)
    worm
    (Caenorhabditis elegans)
    Secernentea hyl-16
    hyl-26
    Protein HYL-2 (hyl-2) mRNA, complete cds
    27(a)
    26(a)
    many ↔ many
    many ↔ many
    IV(8540554-8544379) WBGene00002043
    X(4696785-4699461) WBGene00002044
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G262001 AT1G26200 45.66(n)
    32.88(a)
      3766796  NM_001160896.1  NP_001154368.1 


    ENSEMBL Gene Tree for CERS6 (if available)
    TreeFam Gene Tree for CERS6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CERS6 gene
    CERS22  CERS42  CERS12  CERS52  CERS32  
    5 SIMAP similar genes for CERS6 using alignment to 1 protein entry:     CERS6_HUMAN:
    CERS5    LASS5    CERS2    CERS3    CERS4

    Find genes that share paralogs with CERS6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CERS6 (see all 6343)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs667037041,2
    C--168773314(+) TTTTT-/TTGAGAA 2 -- int11Minor allele frequency- TT:0.00NA 2
    rs1866189051,2
    --169310789(+) AGCATC/GACATT 2 -- us2k10--------
    rs26025661,2
    C,F--169310951(-) TTCTTC/TTCAGT 2 -- us2k13Minor allele frequency- T:0.07WA NA EA 358
    rs1890607891,2
    --169311031(+) CACACA/GACCTG 2 -- us2k10--------
    rs1116094341,2
    F--169311341(+) CCTGCC/ATGTTG 2 -- us2k12Minor allele frequency- A:0.50CSA 4
    rs1148638761,2
    C,F--169311488(+) TTTCAA/GTGCAG 2 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1483517561,2
    --169311498(+) GCAGAC/GGAGAC 2 -- us2k10--------
    rs580286701,2
    C--169311632(+) ACTCC-/CTCTCTC 2 -- us2k10--------
    rs1113074011,2
    C--169311636(+) CTCTC-/TG    
       
    /TGTG
    TCTGT
    2 -- us2k11CSA 2
    rs64330661,2
    C,F,A,H--169311638(+) TCTCtG/Ctgtgt 2 -- us2k1 trp35Minor allele frequency- C:0.22NA WA CSA 9

    HapMap Linkage Disequilibrium report for CERS6 (169312372 - 169562372 bp, first 250kb of CERS6)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CERS6 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1983529CNV Deletion18987734
    esv2721105CNV Deletion23290073
    esv2567946CNV Deletion19546169
    esv2350302CNV Deletion18987734
    esv2721108CNV Deletion23290073
    esv2721103CNV Deletion23290073
    esv4907CNV Deletion18987735
    esv2667449CNV Deletion23128226
    esv3263CNV Deletion18987735
    esv2663091CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CERS6
    DNA2.0 Custom Variant and Variant Library Synthesis for CERS6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615336    OMIM disorders: --


    Find genes that share disorders with CERS6           About GenesLikeMe


    Export disorders for CERS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CERS6 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with CERS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS. (PubMed id 23538298)1 Hartmann D....GrAPsch S. (amp 2013)
    4. Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6. (PubMed id 23519469)1 Hoeferlin L.A....Krupenko N.I. (J. Biol. Chem. 2013)
    5. Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis. (PubMed id 22544924)1 Schiffmann S....Geisslinger G. (J. Immunol. 2012)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network. (PubMed id 22013072)1 Senkal C.E....Ogretmen B. (J. Biol. Chem. 2011)
    9. Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression. (PubMed id 19912991)1 Erez-Roman R....Futerman A.H. (Biochem. Biophys. Res. Commun. 2010)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 253782 HGNC: 23826 AceView: LASS6.1 Ensembl:ENSG00000172292 euGenes: HUgn253782
    ECgene: CERS6 Kegg: 253782 H-InvDB: CERS6

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CERS6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CERS6 gene:
    Search GeneIP for patents involving CERS6

    GeneCards and IP:
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