Aliases for CERS5 Gene
External Ids for CERS5 Gene
Previous HGNC Symbols for CERS5 Gene
Previous GeneCards Identifiers for CERS5 Gene
This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
GeneCards Summary for CERS5 Gene
CERS5 (Ceramide Synthase 5) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sphingosine N-acyltransferase activity. An important paralog of this gene is CERS4.
UniProtKB/Swiss-Prot for CERS5 Gene
Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By similarity).