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Aliases for CERS5 Gene

Aliases for CERS5 Gene

  • Ceramide Synthase 5 2 3
  • LASS5 3 4 6
  • LAG1 Longevity Assurance Homolog 5 3 4
  • LAG1 Homolog, Ceramide Synthase 5 2 3
  • Trh4 3 6
  • LAG1 Longevity Assurance Homolog 5 (S. Cerevisiae) 2
  • EC 2.3.1.24 4
  • CERS5 4

External Ids for CERS5 Gene

Previous HGNC Symbols for CERS5 Gene

  • LASS5

Previous GeneCards Identifiers for CERS5 Gene

  • GC12M050524

Summaries for CERS5 Gene

Entrez Gene Summary for CERS5 Gene

  • This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for CERS5 Gene

CERS5 (Ceramide Synthase 5) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sphingosine N-acyltransferase activity. An important paralog of this gene is CERS4.

UniProtKB/Swiss-Prot for CERS5 Gene

  • Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERS5 Gene

Genomics for CERS5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CERS5 Gene

Start:
50,129,306 bp from pter
End:
50,167,533 bp from pter
Size:
38,228 bases
Orientation:
Minus strand

Genomic View for CERS5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CERS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERS5 Gene

No data available for Regulatory Elements for CERS5 Gene

Proteins for CERS5 Gene

  • Protein details for CERS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5B7-CERS5_HUMAN
    Recommended name:
    Ceramide synthase 5
    Protein Accession:
    Q8N5B7
    Secondary Accessions:
    • B4DV54

    Protein attributes for CERS5 Gene

    Size:
    392 amino acids
    Molecular mass:
    45752 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CERS5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CERS5 Gene

Proteomics data for CERS5 Gene at MOPED

Post-translational modifications for CERS5 Gene

  • Ubiquitination at Lys113 and Lys121
  • Glycosylation at Asn26
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CERS5 Gene

Domains for CERS5 Gene

Gene Families for CERS5 Gene

HGNC:
  • CERS :Homeoboxes / CERS class

Graphical View of Domain Structure for InterPro Entry

Q8N5B7

UniProtKB/Swiss-Prot:

CERS5_HUMAN :
  • Q8N5B7
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
genes like me logo Genes that share domains with CERS5: view

Function for CERS5 Gene

Molecular function for CERS5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + sphingosine = CoA + N-acylsphingosine
UniProtKB/Swiss-Prot Function:
Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By similarity).

Enzyme Numbers (IUBMB) for CERS5 Gene

Gene Ontology (GO) - Molecular Function for CERS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0050291 sphingosine N-acyltransferase activity IDA 16951403
genes like me logo Genes that share ontologies with CERS5: view

Animal Model Products

miRNA for CERS5 Gene

miRTarBase miRNAs that target CERS5

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CERS5 Gene

Localization for CERS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERS5 Gene

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for CERS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with CERS5: view

No data available for Subcellular locations from COMPARTMENTS for CERS5 Gene

Pathways for CERS5 Gene

genes like me logo Genes that share pathways with CERS5: view

Pathways by source for CERS5 Gene

UniProtKB/Swiss-Prot Q8N5B7-CERS5_HUMAN

  • Pathway: Lipid metabolism; sphingolipid metabolism

Interacting Proteins for CERS5 Gene

Gene Ontology (GO) - Biological Process for CERS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process TAS --
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046513 ceramide biosynthetic process IDA 16951403
genes like me logo Genes that share ontologies with CERS5: view

Transcripts for CERS5 Gene

Unigene Clusters for CERS5 Gene

Ceramide synthase 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CERS5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CERS5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b ^ 11 ^ 12a · 12b ·
SP1: - - - - - - - - - -
SP2:
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - -
SP10: - -
SP11: - - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - -
SP14:
SP15:
SP16: - - - - - - - - -
SP17: - - - - - - -
SP18: - - - - - - - - - - -
SP19:
SP20:
SP21:

ExUns: 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19a · 19b · 19c
SP1: - - - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - - - - -
SP16:
SP17:
SP18:
SP19:
SP20: - - -
SP21: -

Relevant External Links for CERS5 Gene

GeneLoc Exon Structure for
CERS5
ECgene alternative splicing isoforms for
CERS5

Expression for CERS5 Gene

mRNA expression in normal human tissues for CERS5 Gene

Protein differential expression in normal tissues for CERS5 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (55.8) and Heart (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CERS5 Gene

SOURCE GeneReport for Unigene cluster for CERS5 Gene Hs.270525

genes like me logo Genes that share expressions with CERS5: view

Expression partners for CERS5 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CERS5 Gene

Orthologs for CERS5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERS5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CERS5 35
  • 90.46 (n)
  • 89.76 (a)
LASS5 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CERS5 35
  • 91.16 (n)
  • 89.54 (a)
CERS5 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cers5 35
  • 82.57 (n)
  • 76.53 (a)
Cers5 16
Cers5 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LASS5 35
  • 99.19 (n)
  • 98.48 (a)
CERS5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cers5 35
  • 81.76 (n)
  • 78.01 (a)
chicken
(Gallus gallus)
Aves CERS5 35
  • 74.98 (n)
  • 78.15 (a)
CERS5 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CERS5 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cers5 35
  • 68.94 (n)
  • 72.44 (a)
Str.2155 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.17394 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
cers5 35
  • 66.93 (n)
  • 71.02 (a)
cers5 36
  • 70 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3018 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001761 35
  • 50.73 (n)
  • 40.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta schlank 35
  • 53.16 (n)
  • 44.48 (a)
schlank 36
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hyl-1 35
  • 47.28 (n)
  • 36.39 (a)
hyl-1 36
  • 30 (a)
ManyToMany
hyl-2 36
  • 30 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LOH2 35
  • 45.59 (n)
  • 32.02 (a)
rice
(Oryza sativa)
Liliopsida Os03g0264000 35
  • 47.71 (n)
  • 33.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9504 36
  • 40 (a)
OneToMany
Species with no ortholog for CERS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERS5 Gene

ENSEMBL:
Gene Tree for CERS5 (if available)
TreeFam:
Gene Tree for CERS5 (if available)

Paralogs for CERS5 Gene

Paralogs for CERS5 Gene

genes like me logo Genes that share paralogs with CERS5: view

Variants for CERS5 Gene

Sequence variations from dbSNP and Humsavar for CERS5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs7279 -- 50,130,164(-) CTCCT(C/T)CTTTT utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs7532 -- 50,130,181(-) ATGCC(A/G)ACTCC utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs1554845 -- 50,129,721(+) TCAGA(C/T)CTGGA utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs2242507 -- 50,133,031(+) GTGGA(A/G)AGTAC intron-variant, nc-transcript-variant
rs2293556 -- 50,130,081(+) GGAAC(A/G)GTACA utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CERS5 Gene

Variant ID Type Subtype PubMed ID
esv2672487 CNV Deletion 23128226
esv2674859 CNV Deletion 23128226

Relevant External Links for CERS5 Gene

HapMap Linkage Disequilibrium report
CERS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERS5 Gene

Disorders for CERS5 Gene

No disorders were found for CERS5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CERS5 Gene

Publications for CERS5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. (PMID: 16100120) Lahiri S. … Futerman A.H. (J. Biol. Chem. 2005) 3 23
  3. The CLN9 protein, a regulator of dihydroceramide synthase. (PMID: 16303764) Schulz A. … Boustany R.M. (J. Biol. Chem. 2006) 23
  4. Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants. (PMID: 16550190) van Hall T. … Offringa R. (Nat. Med. 2006) 23
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CERS5 Gene

Sources for CERS5 Gene

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