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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CERS5 Gene

protein-coding   GIFtS: 50
GCID: GC12M050524

Ceramide Synthase 5

(Previous names: LAG1 longevity assurance homolog 5 (S. cerevisiae), LAG1...)
(Previous symbol: LASS5)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ceramide Synthase 51 2     LAG1 Longevity Assurance Homolog 5 (S. Cerevisiae)1
LASS51 2 3     Trh42
LAG1 Homolog, Ceramide Synthase 51 2     CerS53
LAG1 Longevity Assurance Homolog 52 3     

External Ids:    HGNC: 237491   Entrez Gene: 910122   Ensembl: ENSG000001396247   OMIM: 6153355   UniProtKB: Q8N5B73   

Export aliases for CERS5 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CERS5 Gene:
This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The
encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular
signaling pathways. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for CERS5 Gene: 
CERS5 (ceramide synthase 5) is a protein-coding gene. Diseases associated with CERS5 include hypoxia, and among its related super-pathways are Sphingolipid metabolism and Metabolic pathways. GO annotations related to this gene include sphingosine N-acyltransferase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CERS2.

UniProtKB/Swiss-Prot: CERS5_HUMAN, Q8N5B7
Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed
in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked
palmitoyl- (C16) ceramide) in a fumonisin B1-independent manner (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CERS5
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCERS5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CERS5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CERS5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

CERS5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CERS5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M050524:  view genomic region     (about GC identifiers)

Start:
50,523,575 bp from pter      End:
50,561,288 bp from pter
Size:
37,714 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CERS5_HUMAN, Q8N5B7 (See protein sequence)
Recommended Name: Ceramide synthase 5  
Size: 392 amino acids; 45752 Da
Subcellular location: Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane;
Multi-pass membrane protein (By similarity)

Explore the universe of human proteins at neXtProt for CERS5: NX_Q8N5B7

Explore proteomics data for CERS5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N5B7

  • CERS5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CERS5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001268660.1  NP_671723.1  

    ENSEMBL proteins: 
     ENSP00000448794   ENSP00000369536   ENSP00000447410   ENSP00000325485   ENSP00000449311  
     ENSP00000447266   ENSP00000447029   ENSP00000407896   ENSP00000442918   ENSP00000448295  
     ENSP00000448755   ENSP00000446937   ENSP00000448257   ENSP00000446931   ENSP00000450072  
     ENSP00000389050  
    Reactome Protein details: Q8N5B7
    Human Recombinant Protein Products for CERS5: 
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    Novus Biologicals CERS5 Proteins
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0031965nuclear membrane IEA--

    CERS5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CERS: Homeoboxes / CERS class

    4 InterPro protein domains:
     IPR016439 Longevity_assurance_LAG1_LAC1
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like
     IPR006634 TLC-dom

    Graphical View of Domain Structure for InterPro Entry Q8N5B7

    ProtoNet protein and cluster: Q8N5B7

    2 Blocks protein domains:
    IPB005547 Longevity-assurance protein (LAG1)
    IPB006634 TRAM


    UniProtKB/Swiss-Prot: CERS5_HUMAN, Q8N5B7
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain


    CERS5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CERS5_HUMAN, Q8N5B7
    Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed
    in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked
    palmitoyl- (C16) ceramide) in a fumonisin B1-independent manner (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0050291sphingosine N-acyltransferase activity IDA16951403
         
    CERS5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Cers5 (no phenotypes)

    CERS5 for phenotypes           About GeneDecksing

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidCERS5 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CERS5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.63
    Sphingolipid de novo biosynthesis0.47
    Sphingolipid metabolism0.63
    Sphingolipid Metabolism0.42
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CERS5
        Sphingolipid Metabolism

    4        Reactome Pathways for CERS5
        Sphingolipid metabolism
    Metabolism
    Metabolism of lipids and lipoproteins
    Sphingolipid de novo biosynthesis


    2         Kegg Pathways  (Kegg details for CERS5):
        Sphingolipid metabolism
    Metabolic pathways


    CERS5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CERS5

    3 Interacting proteins for CERS5 (Q8N5B73) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EWSR1Q018443I2D: score=1 
    SERTAD1Q9UHV23I2D: score=1 
    WWTR1Q9GZV53I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006665sphingolipid metabolic process TAS--
    GO:0030148sphingolipid biosynthetic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046513ceramide biosynthetic process IDA16951403

    CERS5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CERS5

    Search CenterWatch for drugs/clinical trials and news about CERS5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CERS5 gene (2 alternative transcripts): 
    NM_001281731.1  NM_147190.3  

    Unigene Cluster for CERS5:

    Ceramide synthase 5
    Hs.270525  [show with all ESTs]
    Unigene Representative Sequence: BC033558
    18/28 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000551697 ENST00000380189(uc001rwf.4) ENST00000551005(uc001rwc.3)
    ENST00000547787(uc001rwd.4 uc001rwe.4) ENST00000317551(uc010smq.1)
    ENST00000546406 ENST00000550919 ENST00000553122 ENST00000550079 ENST00000551757
    ENST00000548942 ENST00000550547 ENST00000438450 ENST00000547138 ENST00000546676
    ENST00000542320 ENST00000547800 ENST00000549089
    miRNA
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    hsa-miR-3130-5p hsa-miR-647 hsa-miR-1276 hsa-miR-3202 hsa-miR-34b hsa-miR-1284 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidCERS5 3' UTR sequence
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    Additional mRNA sequence: 

    AK026014.1 AK027087.1 AK055740.1 AK058033.1 AK294521.1 AK298924.1 AK300937.1 AK308930.1 
    BC014637.1 BC032565.1 BC033558.1 U15426.1 

    20 DOTS entries:

    DT.100805869  DT.100025003  DT.70104773  DT.444776  DT.97816602  DT.92436993  DT.428724  DT.95098210 
    DT.91675317  DT.121183231  DT.86838936  DT.97796847  DT.97845422  DT.100805870  DT.121183195  DT.75197877 
    DT.91952126  DT.92436989  DT.92436992  DT.121183191 

    24/243 AceView cDNA sequences (see all 243):

    AA417054 CB216425 BM798014 CB137489 BQ721513 BM711803 Z42984 BM665614 
    BC033558 CR602245 AA056080 BX113560 AA489165 BX118634 CA439004 AA236771 
    AI151163 BI870365 AA053726 BC014637 AA018127 AA814619 BE742669 AL582011 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for CERS5 (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b ^ 11 ^ 12a · 12b ·
    SP1:                                      -     -     -     -     -     -     -     -           -     -                                                         
    SP2:                                                                                                                                                            
    SP3:                                      -     -     -     -           -     -     -           -     -                                                         
    SP4:                                      -     -     -     -     -     -     -     -           -     -                                               -     -   
    SP5:                                      -     -     -     -     -     -     -     -           -     -                             -     -                     

    ExUns: 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19a · 19b · 19c
    SP1:                                      -     -     -                 -     -     -                     
    SP2:                                      -     -     -                       -     -                     
    SP3:                                                                                                      
    SP4:  -     -                                                                                             
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for CERS5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CERS5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGAGGGT
    CERS5 Expression
    About this image


    See CERS5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CERS5

    SOURCE GeneReport for Unigene cluster: Hs.270525
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CERS5 gene from 10/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cers55
    Lass51
    LAG1 homolog, ceramide synthase 51, 5 82.57(n)1
    76.53(a)1
      15 (56.13 cM)5
    719491  NM_028015.21  NP_082291.11 
     997335065 
    chicken
    (Gallus gallus)
    Aves CERS51 ceramide synthase 5 74.89(n)
    78.15(a)
      426879  XM_424486.2  XP_424486.2 
    lizard
    (Anolis carolinensis)
    Reptilia CERS56
    Uncharacterized protein
    74(a)
    1 ↔ 1
    2(91595611-91620288)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.173942 Xenopus laevis TRH4 (TRH4) mRNA, complete cds 74.5(n)    AF483906.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053143.12   -- 76.89(n)   323020  BC053143.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta schlank1 CG3576-PA 53.43(n)
    46(a)
      50392  NM_144269.3  NP_652526.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hyl-11 Protein HYL-1 47.1(n)
    36.39(a)
      177660  NM_069058.5  NP_501459.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LAC16
    LAG16
    Ceramide synthase component, involved in synthesis...
    Ceramide synthase component, involved in synthesis...
    19(a)
    17(a)
    many ↔ many
    many ↔ many
    XI(427295-428551)
    VIII(100648-101883)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LOH21 LAG1 longevity assurance homolog 2 43.48(n)
    32.27(a)
      821460  NM_112813.1  NP_188557.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02640001 hypothetical protein 47.35(n)
    35.98(a)
      4332339  NM_001056174.1  NP_001049639.1 


    ENSEMBL Gene Tree for CERS5 (if available)
    TreeFam Gene Tree for CERS5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CERS5 gene
    CERS22  CERS42  CERS12  CERS62  CERS32  
    13 SIMAP similar genes for CERS5 using alignment to 14 protein entries:     CERS5_HUMAN (see all proteins):
    LASS5    ZNF611    SNX1    CLUL1    TMEM14B    CERS6
    UBIAD1    MPP4    NSRP1    CERS2    CERS4    C10orf137
    CERS3

    CERS5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/839 SNPs in CERS5 are shown (see all 839)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850923661,2
    --50523128(+) AGCTAC/TACCAA 1 -- int10--------
    rs57981281,2
    C--50523285(+) tttttT/-ttttt 1 -- int12Minor allele frequency- -:0.25NA 4
    rs2004452291,2
    C--50523475(+) AAAAA-/TTTTTGG 1 -- int10--------
    rs795377431,2
    C,F--50523496(+) CTTCTG/CAATCA 1 -- int11Minor allele frequency- C:0.05WA 118
    rs15548451,2
    C,F,O,A,H--50523504(+) TCAGAC/TCTGGA 1 -- int121Minor allele frequency- T:0.30MN NA NS EA WA 1518
    rs123024651,2
    C,F,H--50523529(+) GCTTAT/CGGATT 1 -- int111Minor allele frequency- C:0.03NS EA NA WA 1310
    rs1904138961,2
    --50523545(+) AACTGC/TGGATA 1 -- int10--------
    rs123224081,2
    C,H--50523577(+) CAGTAG/AAGGTG 1 -- int14Minor allele frequency- A:0.00NS EA 416
    rs105381421,2
    C--50523602(+) TAATC-/ACAA  
            
    ACAAA
    1 -- ut312Minor allele frequency- ACAA:0.25NA CSA 4
    rs1458637781,2
    --50523647(+) TGGCT-/GGGGGG
            
    GTTGC
    1 -- cds10--------

    HapMap Linkage Disequilibrium report for CERS5 (50523575 - 50561288 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CERS5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672487CNV Deletion23128226
    esv2674859CNV Deletion23128226

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615335    OMIM disorders: --

    2 diseases for CERS5:    About MalaCards
    hypoxia    


    CERS5 for disorders           About GeneDecksing


    Export disorders for CERS5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CERS5 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CERS5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. (PubMed id 16100120)1, 9 Lahiri S. and Futerman A.H. (2005)
    3. Ceramide synthases at the centre of sphingolipid metab olism and biology. (PubMed id 22248339)1 Mullen T.D....Obeid L.M. (2012)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. (PubMed id 20406683)1 Mesicek J....Kolesnick R. (2010)
    6. Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. (PubMed id 18676372)1 Jin J....Hsu Y.T. (2008)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
    8. Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity. (PubMed id 16951403)1 Spassieva S....Obeid L.M. (2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. (PubMed id 17030510)1 Kitatani K....Hannun Y.A. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91012 HGNC: 23749 AceView: LASS5 Ensembl:ENSG00000139624 euGenes: HUgn91012
    ECgene: CERS5 Kegg: 91012 H-InvDB: CERS5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CERS5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CERS5 gene:
    Search GeneIP for patents involving CERS5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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