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Aliases for CERS5 Gene

Aliases for CERS5 Gene

  • Ceramide Synthase 5 2 3 5
  • LAG1 Longevity Assurance Homolog 5 3 4
  • LAG1 Homolog, Ceramide Synthase 5 2 3
  • LASS5 3 4
  • LAG1 Longevity Assurance Homolog 5 (S. Cerevisiae) 2
  • TRAM Homolog 4 3
  • EC 2.3.1.24 4
  • CerS5 4
  • Trh4 3

External Ids for CERS5 Gene

Previous HGNC Symbols for CERS5 Gene

  • LASS5

Previous GeneCards Identifiers for CERS5 Gene

  • GC12M050524

Summaries for CERS5 Gene

Entrez Gene Summary for CERS5 Gene

  • This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for CERS5 Gene

CERS5 (Ceramide Synthase 5) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Sphingolipid signaling pathway. GO annotations related to this gene include sphingosine N-acyltransferase activity. An important paralog of this gene is CERS6.

UniProtKB/Swiss-Prot for CERS5 Gene

  • Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERS5 Gene

Genomics for CERS5 Gene

Regulatory Elements for CERS5 Gene

Enhancers for CERS5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G050106 1.4 ENCODE dbSUPER 36.4 +57.5 57457 6.6 MLX CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 CERS5 ATF1 CSRNP2 LIMA1 PRPF40B COX14 ENSG00000272368 GC12M050105
GH12G050279 1.3 ENCODE dbSUPER 34.9 -114.5 -114549 5.3 HDGF CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF143 CERS5 TFCP2 CSRNP2 PRPF40B FAM186A LARP4 DIP2B LIMA1 GC12M050258
GH12G050504 1.7 FANTOM5 ENCODE dbSUPER 24.6 -339.7 -339747 5.9 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A YY1 CBX5 CERS5 TFCP2 CSRNP2 DIP2B RNU6-769P PRPF40B ATF1 AQP6 GC12P050634
GH12G050200 1.4 Ensembl ENCODE dbSUPER 29.6 -35.0 -34954 4.6 HDAC1 SIN3A NFXL1 BRCA1 RAD21 RFX5 EGR1 GATA2 SCRT2 ETV6 CERS5 RNU6-1093P LIMA1 COX14 LARP4 FAM186A ATF1 ENSG00000257298 PIR58326
GH12G050166 1.1 ENCODE 33.6 +0.1 149 2.3 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 YY1 CERS5 CSRNP2 GC12P050120
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CERS5 on UCSC Golden Path with GeneCards custom track

Promoters for CERS5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000051731 333 1601 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 YY1

Genomic Location for CERS5 Gene

Chromosome:
12
Start:
50,129,306 bp from pter
End:
50,167,533 bp from pter
Size:
38,228 bases
Orientation:
Minus strand

Genomic View for CERS5 Gene

Genes around CERS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERS5 Gene

Proteins for CERS5 Gene

  • Protein details for CERS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5B7-CERS5_HUMAN
    Recommended name:
    Ceramide synthase 5
    Protein Accession:
    Q8N5B7
    Secondary Accessions:
    • B4DV54

    Protein attributes for CERS5 Gene

    Size:
    392 amino acids
    Molecular mass:
    45752 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CERS5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CERS5 Gene

Post-translational modifications for CERS5 Gene

  • Ubiquitination at posLast=113113 and posLast=121121
  • Glycosylation at posLast=2626
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CERS5 Gene

Domains & Families for CERS5 Gene

Gene Families for CERS5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CERS5: view

No data available for UniProtKB/Swiss-Prot for CERS5 Gene

Function for CERS5 Gene

Molecular function for CERS5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acyl-CoA + sphingosine = CoA + N-acylsphingosine.
UniProtKB/Swiss-Prot Function:
Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By similarity).

Enzyme Numbers (IUBMB) for CERS5 Gene

Gene Ontology (GO) - Molecular Function for CERS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0016740 transferase activity IEA --
GO:0050291 sphingosine N-acyltransferase activity TAS --
genes like me logo Genes that share ontologies with CERS5: view
genes like me logo Genes that share phenotypes with CERS5: view

Animal Models for CERS5 Gene

MGI Knock Outs for CERS5:

Animal Model Products

CRISPR Products

miRNA for CERS5 Gene

miRTarBase miRNAs that target CERS5

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CERS5 Gene

Localization for CERS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERS5 Gene

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CERS5 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
plasma membrane 3
lysosome 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CERS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CERS5: view

Pathways & Interactions for CERS5 Gene

genes like me logo Genes that share pathways with CERS5: view

Pathways by source for CERS5 Gene

UniProtKB/Swiss-Prot Q8N5B7-CERS5_HUMAN

  • Pathway: Lipid metabolism; sphingolipid metabolism.

Gene Ontology (GO) - Biological Process for CERS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0046513 ceramide biosynthetic process IDA 16951403
genes like me logo Genes that share ontologies with CERS5: view

No data available for SIGNOR curated interactions for CERS5 Gene

Drugs & Compounds for CERS5 Gene

(3) Drugs for CERS5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Coenzyme A Nutra 0

(81) Additional Compounds for CERS5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
244215-65-4
3-O-Sulfogalactosylceramide (d18:1/18:1(9Z))
  • 3'-O-Sulphogalactosylceramide
  • 3-O-Sulfo-beta-D-galactosylceramide
  • 3-O-Sulfo-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
  • Cerebroside 3-sulfate
genes like me logo Genes that share compounds with CERS5: view

Transcripts for CERS5 Gene

Unigene Clusters for CERS5 Gene

Ceramide synthase 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CERS5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b ^ 11 ^ 12a · 12b ·
SP1: - - - - - - - - - -
SP2:
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - - -
SP8: - - - - - - - - - - -
SP9: - -
SP10: - -
SP11: - - - - - - - - -
SP12: - - - - - - - -
SP13: - - - - - - - - -
SP14:
SP15:
SP16: - - - - - - - - -
SP17: - - - - - - -
SP18: - - - - - - - - - - -
SP19:
SP20:
SP21:

ExUns: 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19a · 19b · 19c
SP1: - - - - - -
SP2: - - - - -
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: - - - - -
SP16:
SP17:
SP18:
SP19:
SP20: - - -
SP21: -

Relevant External Links for CERS5 Gene

GeneLoc Exon Structure for
CERS5
ECgene alternative splicing isoforms for
CERS5

Expression for CERS5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CERS5 Gene

Protein differential expression in normal tissues from HIPED for CERS5 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (55.8) and Heart (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CERS5 Gene



Protein tissue co-expression partners for CERS5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CERS5 Gene:

CERS5

SOURCE GeneReport for Unigene cluster for CERS5 Gene:

Hs.270525

Evidence on tissue expression from TISSUES for CERS5 Gene

  • Intestine(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with CERS5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CERS5 Gene

Orthologs for CERS5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LASS5 34
  • 99.19 (n)
CERS5 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CERS5 34 35
  • 91.16 (n)
cow
(Bos Taurus)
Mammalia CERS5 34
  • 90.46 (n)
LASS5 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cers5 34 16 35
  • 82.57 (n)
rat
(Rattus norvegicus)
Mammalia Cers5 34
  • 81.76 (n)
chicken
(Gallus gallus)
Aves CERS5 34 35
  • 74.98 (n)
lizard
(Anolis carolinensis)
Reptilia CERS5 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cers5 34
  • 68.94 (n)
Str.2155 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.17394 34
zebrafish
(Danio rerio)
Actinopterygii cers5 34 35
  • 66.93 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3018 34
fruit fly
(Drosophila melanogaster)
Insecta schlank 34 35
  • 53.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001761 34
  • 50.73 (n)
worm
(Caenorhabditis elegans)
Secernentea hyl-1 34 35
  • 47.28 (n)
hyl-2 35
  • 30 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons LOH2 34
  • 45.59 (n)
rice
(Oryza sativa)
Liliopsida Os03g0264000 34
  • 47.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9504 35
  • 40 (a)
OneToMany
Species where no ortholog for CERS5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERS5 Gene

ENSEMBL:
Gene Tree for CERS5 (if available)
TreeFam:
Gene Tree for CERS5 (if available)

Paralogs for CERS5 Gene

Paralogs for CERS5 Gene

genes like me logo Genes that share paralogs with CERS5: view

Variants for CERS5 Gene

Sequence variations from dbSNP and Humsavar for CERS5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000002868 -- 50,158,422(+) TTTTC(C/G/T)TGTCC intron-variant
rs1000046868 -- 50,135,126(+) AGAGA(A/G)GAGAG intron-variant, downstream-variant-500B
rs1000181253 -- 50,141,892(+) CTGAG(A/T)TTCCA intron-variant
rs1000202158 -- 50,154,684(+) TATTA(-/T)TTTTT intron-variant
rs1000286327 -- 50,163,002(+) CAAGC(A/C)ATCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CERS5 Gene

Variant ID Type Subtype PubMed ID
esv2672487 CNV deletion 23128226
esv2674859 CNV deletion 23128226
esv3629472 CNV loss 21293372
esv3629473 CNV loss 21293372
nsv1144622 CNV deletion 24896259
nsv558840 CNV loss 21841781

Variation tolerance for CERS5 Gene

Residual Variation Intolerance Score: 57.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CERS5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CERS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERS5 Gene

Disorders for CERS5 Gene

Relevant External Links for CERS5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CERS5

No disorders were found for CERS5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CERS5 Gene

Publications for CERS5 Gene

  1. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. (PMID: 16100120) Lahiri S. … Futerman A.H. (J. Biol. Chem. 2005) 3 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region. (PMID: 26887952) Sassa T. … Kihara A. (J. Biol. Chem. 2016) 3 64
  5. Linking the ceramide synthases (CerSs) 4 and 5 with apoptosis, endometrial and colon cancers. (PMID: 25779024) Mojakgomo R. … Dlamini Z. (Exp. Mol. Pathol. 2015) 3 64

Products for CERS5 Gene

Sources for CERS5 Gene

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