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CERS5 Gene

protein-coding   GIFtS: 51
GCID: GC12M050524

Ceramide Synthase 5

(Previous names: LAG1 longevity assurance homolog 5 (S. cerevisiae), LAG1...)
(Previous symbol: LASS5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ceramide Synthase 51 2     Trh42
LASS51 2 3 5     CerS53
LAG1 Homolog, Ceramide Synthase 51 2     EC 2.3.1.243
LAG1 Longevity Assurance Homolog 52 3     TRH45
LAG1 Longevity Assurance Homolog 5 (S. Cerevisiae)1     

External Ids:    HGNC: 237491   Entrez Gene: 910122   Ensembl: ENSG000001396247   OMIM: 6153355   UniProtKB: Q8N5B73   
ORGUL members:         

Export aliases for CERS5 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CERS5 Gene:
This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The
encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular
signaling pathways. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for CERS5 Gene:
CERS5 (ceramide synthase 5) is a protein-coding gene. Diseases associated with CERS5 include hypoxia, and malaria. GO annotations related to this gene include sphingosine N-acyltransferase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CERS2.

UniProtKB/Swiss-Prot: CERS5_HUMAN, Q8N5B7
Function: Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high
selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CERS5
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCERS5 promoter sequence
   Search Chromatin IP Primers for CERS5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CERS5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

CERS5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CERS5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M050524:  view genomic region     (about GC identifiers)

Start:
50,523,575 bp from pter      End:
50,561,288 bp from pter
Size:
37,714 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CERS5_HUMAN, Q8N5B7 (See protein sequence)
Recommended Name: Ceramide synthase 5  
Size: 392 amino acids; 45752 Da

Explore the universe of human proteins at neXtProt for CERS5: NX_Q8N5B7

Explore proteomics data for CERS5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys113, Lys121
  • Glycosylation2 at Asn26
  • Modification sites at PhosphoSitePlus

  • See CERS5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001268660.1  NP_671723.1  

    ENSEMBL proteins: 
     ENSP00000448794   ENSP00000369536   ENSP00000447410   ENSP00000325485   ENSP00000449311  
     ENSP00000447266   ENSP00000447029   ENSP00000407896   ENSP00000442918   ENSP00000448295  
     ENSP00000448755   ENSP00000446937   ENSP00000448257   ENSP00000446931   ENSP00000450072  
     ENSP00000389050  
    Reactome Protein details: Q8N5B7

    CERS5 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

    CERS5 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CERS: Homeoboxes / CERS class

    4 InterPro protein domains:
     IPR016439 Longevity_assurance_LAG1_LAC1
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like
     IPR006634 TLC-dom

    Graphical View of Domain Structure for InterPro Entry Q8N5B7

    ProtoNet protein and cluster: Q8N5B7

    2 Blocks protein domains:
    IPB005547 Longevity-assurance protein (LAG1)
    IPB006634 TRAM


    UniProtKB/Swiss-Prot: CERS5_HUMAN, Q8N5B7
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain


    CERS5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CERS5_HUMAN, Q8N5B7
    Function: Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high
    selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By
    similarity)
    Catalytic activity: Acyl-CoA + sphingosine = CoA + N-acylsphingosine

         Enzyme Number (IUBMB): EC 2.3.1.241

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0050291sphingosine N-acyltransferase activity IDA16951403
         
    CERS5 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Cers5 (no phenotypes)

    CERS5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CERS5
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CERS5

    miRNA
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    miRTarBase miRNAs that target CERS5:
    hsa-mir-484 (MIRT042119)

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    7 qRT-PCR Assays for microRNAs that regulate CERS5:
    hsa-miR-3130-5p hsa-miR-647 hsa-miR-1276 hsa-miR-3202 hsa-miR-34b hsa-miR-1284 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidCERS5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CERS5

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CERS5_HUMAN, Q8N5B7: Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane;
    Multi-pass membrane protein (By similarity)

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0031965nuclear membrane IEA--

    CERS5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CERS5 About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Sphingolipid de novo biosynthesis0.46
    Sphingolipid metabolism0.61
    Sphingolipid Metabolism0.42
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CERS5
        Sphingolipid Metabolism

    1 Reactome Pathway for CERS5
        Sphingolipid de novo biosynthesis


    2 Kegg Pathways  (Kegg details for CERS5):
        Sphingolipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: CERS5_HUMAN, Q8N5B7
    Pathway: Lipid metabolism; sphingolipid metabolism


    CERS5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CERS5
    Interactions:

        Search GeneGlobe Interaction Network for CERS5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for CERS5 (Q8N5B73 ENSP000003254854) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EWSR1Q018443I2D: score=1 
    SERTAD1Q9UHV23I2D: score=1 
    WWTR1Q9GZV53I2D: score=1 
    ACER2ENSP000003426094STRING: ENSP00000342609
    SEC62ENSP000003376884STRING: ENSP00000337688
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006665sphingolipid metabolic process TAS--
    GO:0030148sphingolipid biosynthetic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046513ceramide biosynthetic process IDA16951403

    CERS5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CERS5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CERS5 gene (2 alternative transcripts): 
    NM_001281731.1  NM_147190.3  

    Unigene Cluster for CERS5:

    Ceramide synthase 5
    Hs.270525  [show with all ESTs]
    Unigene Representative Sequence: BC033558
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 28):
    ENST00000551697 ENST00000380189(uc001rwf.4) ENST00000551005(uc001rwc.3)
    ENST00000547787(uc001rwd.4 uc001rwe.4) ENST00000317551(uc010smq.1)
    ENST00000546406 ENST00000550919 ENST00000553122 ENST00000550079 ENST00000551757
    ENST00000548942 ENST00000550547 ENST00000438450 ENST00000547138 ENST00000546676
    ENST00000542320 ENST00000547800 ENST00000549089
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate CERS5:
    hsa-miR-3130-5p hsa-miR-647 hsa-miR-1276 hsa-miR-3202 hsa-miR-34b hsa-miR-1284 hsa-miR-335
    SwitchGear 3'UTR luciferase reporter plasmidCERS5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CERS5
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      QuantiTect SYBR Green Assays in human, mouse, rat CERS5
      QuantiFast Probe-based Assays in human, mouse, rat CERS5

    Additional mRNA sequence: 

    AK026014.1 AK027087.1 AK055740.1 AK058033.1 AK294521.1 AK298924.1 AK300937.1 AK308930.1 
    BC014637.1 BC032565.1 BC033558.1 U15426.1 

    20 DOTS entries:

    DT.100805869  DT.100025003  DT.70104773  DT.444776  DT.97816602  DT.92436993  DT.428724  DT.95098210 
    DT.91675317  DT.121183231  DT.86838936  DT.97796847  DT.97845422  DT.100805870  DT.121183195  DT.75197877 
    DT.91952126  DT.92436989  DT.92436992  DT.121183191 

    Selected AceView cDNA sequences (see all 243):

    AA417054 BX118634 CB137489 AA053726 BC033558 AA018127 AA489165 Z42984 
    AI151163 BX113560 BQ721513 BI870365 AA056080 CR602245 AA236771 BC014637 
    BM665614 BM798014 BM711803 CB216425 CA439004 BM545862 BM918956 BF204938 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CERS5 (see all 21)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f ^ 10a · 10b ^ 11 ^ 12a · 12b ·
    SP1:                                      -     -     -     -     -     -     -     -           -     -                                                         
    SP2:                                                                                                                                                            
    SP3:                                      -     -     -     -           -     -     -           -     -                                                         
    SP4:                                      -     -     -     -     -     -     -     -           -     -                                               -     -   
    SP5:                                      -     -     -     -     -     -     -     -           -     -                             -     -                     

    ExUns: 12c · 12d ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19a · 19b · 19c
    SP1:                                      -     -     -                 -     -     -                     
    SP2:                                      -     -     -                       -     -                     
    SP3:                                                                                                      
    SP4:  -     -                                                                                             
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for CERS5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CERS5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAAGAGGGT
    CERS5 Expression
    About this image

    CERS5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CERS5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.270525
        Custom PCR Arrays for CERS5
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    QuantiFast Probe-based Assays in human, mouse, rat CERS5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CERS5 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cers51 , 5 LAG1 homolog, ceramide synthase 55
    ceramide synthase 51
    82.57(n)1
    76.53(a)1
      15 (56.13 cM)5
    719491  NM_028015.21  NP_082291.11 
     997335065 
    chicken
    (Gallus gallus)
    Aves CERS51 ceramide synthase 5 74.98(n)
    78.15(a)
      426879  XM_004949725.1  XP_004949782.1 
    lizard
    (Anolis carolinensis)
    Reptilia CERS56
    ceramide synthase 5
    74(a)
    1 ↔ 1
    2(91595611-91620288)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.173942 Xenopus laevis TRH4 (TRH4) mRNA, complete cds 74.5(n)    AF483906.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053143.12   -- 76.89(n)   323020  BC053143.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta schlank1 schlank 53.16(n)
    44.48(a)
      50392  NM_144269.3  NP_652526.1 
    worm
    (Caenorhabditis elegans)
    Secernentea hyl-11 hyl-1 47.28(n)
    36.39(a)
      177660  NM_069058.6  NP_501459.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LOH21 LOH2 45.59(n)
    32.02(a)
      821460  NM_112813.1  NP_188557.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02640001 Os03g0264000 47.71(n)
    33.94(a)
      4332339  NM_001056174.1  NP_001049639.1 


    ENSEMBL Gene Tree for CERS5 (if available)
    TreeFam Gene Tree for CERS5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CERS5 gene
    CERS22  CERS42  CERS12  CERS62  CERS32  
    14 SIMAP similar genes for CERS5 using alignment to 13 protein entries:     CERS5_HUMAN (see all proteins):
    LASS5    ZNF611    SNX1    MMAB    CLUL1    TMEM14B
    CERS6    UBIAD1    MPP4    NSRP1    CERS2    CERS4
    EDRF1    CERS3

    CERS5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CERS5 (see all 839)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850923661,2
    --50523128(+) AGCTAC/TACCAA 1 -- int10--------
    rs57981281,2
    C--50523285(+) tttttT/-ttttt 1 -- int12Minor allele frequency- -:0.25NA 4
    rs2004452291,2
    C--50523475(+) AAAAA-/TTTTTGG 1 -- int10--------
    rs795377431,2
    C,F--50523496(+) CTTCTG/CAATCA 1 -- int11Minor allele frequency- C:0.05WA 118
    rs15548451,2
    C,F,O,A,H--50523504(+) TCAGAC/TCTGGA 1 -- int121Minor allele frequency- T:0.30MN NA NS EA WA 1518
    rs123024651,2
    C,F,H--50523529(+) GCTTAT/CGGATT 1 -- int111Minor allele frequency- C:0.03NS EA NA WA 1310
    rs1904138961,2
    --50523545(+) AACTGC/TGGATA 1 -- int10--------
    rs123224081,2
    C,H--50523577(+) CAGTAG/AAGGTG 1 -- int14Minor allele frequency- A:0.00NS EA 416
    rs105381421,2
    C--50523602(+) TAATC-/ACAA  
            
    ACAAA
    1 -- ut312Minor allele frequency- ACAA:0.25NA CSA 4
    rs1458637781,2
    --50523647(+) TGGCT-/GGGGGG
            
    GTTGC
    1 -- cds10--------

    HapMap Linkage Disequilibrium report for CERS5 (50523575 - 50561288 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CERS5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672487CNV Deletion23128226
    esv2674859CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CERS5
    DNA2.0 Custom Variant and Variant Library Synthesis for CERS5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615335    OMIM disorders: --

    2 diseases for CERS5:    
    About MalaCards
    hypoxia    malaria


    CERS5 for disorders           About GeneDecksing


    Export disorders for CERS5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CERS5 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with CERS5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor. (PubMed id 16100120)1, 9 Lahiri S. and Futerman A.H. (J. Biol. Chem. 2005)
    3. Ceramide synthases at the centre of sphingolipid metabolism and biology. (PubMed id 22248339)1 Mullen T.D....Obeid L.M. (Biochem. J. 2012)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells. (PubMed id 20406683)1 Mesicek J....Kolesnick R. (Cell. Signal. 2010)
    6. Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells. (PubMed id 18676372)1 Jin J....Hsu Y.T. (J. Biol. Chem. 2008)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)
    8. Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity. (PubMed id 16951403)1 Spassieva S....Obeid L.M. (J. Biol. Chem. 2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK. (PubMed id 17030510)1 Kitatani K....Hannun Y.A. (J. Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91012 HGNC: 23749 AceView: LASS5 Ensembl:ENSG00000139624 euGenes: HUgn91012
    ECgene: CERS5 Kegg: 91012 H-InvDB: CERS5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CERS5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CERS5 gene:
    Search GeneIP for patents involving CERS5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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