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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CERS4 Gene

protein-coding GIFtS: 51
GCID: GC19P008276

ceramide synthase 4

(Previous names: LAG1 longevity assurance homolog 4 (S. cerevisiae), LAG1...)
(Previous symbol: LASS4)

Explore 3 diseases affiliated with
CERS4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ceramide Synthase 4¹ ²		LAG1 Longevity Assurance Homolog 4² ³
LASS4¹ ² ³		FLJ12089¹
Trh1¹ ²		LAG1 Longevity Assurance Homolog 4 (S. Cerevisiae)¹
LAG1 Homolog, Ceramide Synthase 4¹ ²		CerS4³

External Ids:	HGNC: 23747¹	Entrez Gene: 79603²	Ensembl: ENSG00000090661⁷	UniProtKB: Q9HA82³

Export aliases for CERS4 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CERS4_HUMAN, Q9HA82

Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in

cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18)

or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_077812.2

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for CERS4
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for CERS4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CERS4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.3

CERS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CERS4 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P008276: view genomic region (about GC identifiers)

Start:	8,271,620 bp from pter	End:	8,327,305 bp from pter
Size:	55,686 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CERS4_HUMAN, Q9HA82 (See protein sequence)

Recommended Name: Ceramide synthase 4

Size: 394 amino acids; 46399 Da

Subcellular location: Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane;

Multi-pass membrane protein (By similarity)

Secondary accessions: D6W665

Explore the universe of human proteins at neXtProt for CERS4: NX_Q9HA82

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9HA82

CERS4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_078828.2

ENSEMBL proteins:

ENSP00000453796 ENSP00000453388 ENSP00000452753 ENSP00000452910 ENSP00000251363

ENSP00000453509 ENSP00000453815 ENSP00000452920 ENSP00000454122

Reactome Protein details: Q9HA82
Human Recombinant Protein Products for CERS4:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CERS4

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005783	endoplasmic reticulum	--	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0016021	integral to membrane	IEA	--
GO:0031965	nuclear membrane	IEA	--

CERS4 for ontologies About GeneDecksing

CERS4 Antibody Products:

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Assay Products for CERS4:

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	Uscn ELISAs and CLIAs for CERS4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CERS4 for domains About GeneDecksing

4 InterPro domains/families:

IPR016439 Longevity_assurance_LAG1_LAC1

IPR001356 Homeodomain

IPR009057 Homeodomain-like

IPR006634 TLC-dom

Graphical View of Domain Structure for InterPro Entry Q9HA82

ProtoNet protein and cluster: Q9HA82

2 Blocks protein families:

IPB005547 Longevity-assurance protein (LAG1)

IPB006634 TRAM

UniProtKB/Swiss-Prot: CERS4_HUMAN, Q9HA82

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CERS4_HUMAN, Q9HA82

Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in

cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18)

or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--
GO:0050291	sphingosine N-acyltransferase activity	IEA	--

CERS4 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CERS4:

Decreased influenza A/WSN/33 r

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CERS4

miRNA Products:		OriGene 3'-UTR Clone: CERS4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CERS4
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CERS4:
		hsa-miR-339-5p
		SwitchGear 3'UTR luciferase reporter plasmid: CERS4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CERS4 (see all 4) OriGene shRNA RFP: CERS4 OriGene siRNA: CERS4
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CERS4

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CERS4
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CERS4 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CERS4 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for CERS4
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CERS4
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS4

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sphingolipid metabolism

Sphingolipid metabolism

1.00

Sphingolipid de novo biosynthesis

0.46

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for CERS4

	Sphingolipid metabolism
	Metabolism
	Metabolism of lipids and lipoproteins
	Sphingolipid de novo biosynthesis

CERS4 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CERS4

2 Interacting proteins for CERS4 (Q9HA82^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OLIG1	Q8TAK6³	I2D: score=1
--	Q1HVH9²	MINT-6769802

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006665	sphingolipid metabolic process	TAS	--
GO:0030148	sphingolipid biosynthetic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0046513	ceramide biosynthetic process	IEA	--

CERS4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CERS4
Search CenterWatch for drugs/clinical trials and news about CERS4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CERS4 gene:

NM_024552.2

Unigene Cluster for CERS4:

Ceramide synthase 4

Hs.515111 [show with all ESTs]

Unigene Representative Sequence: AK055414

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000561008 ENST00000558268 ENST00000558331(uc002mjg.3 uc002mji.3)

ENST00000561053 ENST00000559490 ENST00000251363 ENST00000559450 ENST00000559336(uc010dvz.3)

ENST00000558501 ENST00000560412 ENST00000558877 ENST00000557925 ENST00000558302

miRNA Products:		OriGene 3'-UTR Clone: CERS4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CERS4
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CERS4:
		hsa-miR-339-5p
		SwitchGear 3'UTR luciferase reporter plasmid: CERS4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CERS4 (see all 4) OriGene shRNA RFP: CERS4 OriGene siRNA: CERS4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CERS4
		Sirion Biotech Custom design and validation of potent shRNA sequences against CERS4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CERS4 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CERS4 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for CERS4
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CERS4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CERS4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CERS4

Additional cDNA sequence:

AK022151.1 AK055414.1 AK222621.1 AK225394.1 BC009828.2 BC063621.1

18 DOTS entries:

DT.75103241 DT.91741576 DT.95113227 DT.97773877 DT.113394 DT.100019238 DT.97782292 DT.100829415

DT.95113232 DT.100811526 DT.95336878 DT.100749538 DT.86856887 DT.91741577 DT.91873859 DT.97803812

DT.91659967 DT.99959718

24/184 AceView cDNA sequences (see all 184):

BM667138 CR623019 BQ214330 BM045289 BM927305 BU149864 BF724636 BM909942

BU838297 BG695862 AW135503 BI822463 CR614629 CR598338 BE893168 AW440633

BU674824 BQ684050 BM697971 BI490050 BQ059431 NM_024552 BI754920 BI823116

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CERS4 (see all 7) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16
SP1:											-		-								-		-		-		-
SP2:											-		-				-		-		-		-
SP3:
SP4:											-						-		-		-		-
SP5:											-		-				-		-		-

ECgene alternative splicing isoforms for CERS4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CERS4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAAGGGCC

About this image

CERS4 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CERS4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CERS4

SOURCE GeneReport for Unigene cluster: Hs.515111

SABiosciences Custom PCR Arrays for CERS4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CERS4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CERS4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CERS4 gene from 4/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LASS4¹	ceramide synthase 4	61.28(n) 55.07(a)		420050 XM_418172.3 XP_418172.2
zebrafish (Danio rerio)	Actinopterygii	LOC100330155¹	LAG1 longevity assurance homolog 2-like	56.77(n) 50.14(a)		100330155 XM_002660974.2 XP_002661020.2
fruit fly (Drosophila melanogaster)	Insecta	schlank⁶	schlank	35(a)	possible ortholog	X(6151701-6161260)
worm (Caenorhabditis elegans)	Secernentea	hyl-2⁶ hyl-1⁶	Homolog of Yeast Longevity gene family member (hyl... Homolog of Yeast Longevity gene family member (hyl...	24(a) 24(a)	many ↔ many many ↔ many	X(4697218-4699433) IV(8540541-8544366)

ENSEMBL Gene Tree for CERS4 (if available)
TreeFam Gene Tree for CERS4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CERS4 gene

CERS2² CERS1² CERS6² CERS5² CERS3²

6 SIMAP similar genes for CERS4 using alignment to 9 protein entries: CERS4_HUMAN (see all proteins):

CERS2 CERS3 CERS5 CERS6 LASS5 LASS1

CERS4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs180781461^1,2		--	8272329(+)	`CCCAGA/GCTGCA`	1	--	us2k¹		0	--	--	--	--
rs150761679^1,2		--	8272546(+)	`GCCACA/GTTGGC`	1	--	us2k¹		0	--	--	--	--
rs187609427^1,2		--	8272641(+)	`ACCCAC/GCCTCT`	1	--	us2k¹		0	--	--	--	--
rs7253890^1,2	C	--	8272775(+)	`aacatT/Agtgaa`	1	--	us2k¹		6		NA WA CSA EA	246
rs199960507^1,2		--	8272808(+)	`AAATA-/TATATA`	1	--	us2k¹		0	--	--	--	--
rs62126381^1,2	C,F	--	8272852(+)	`AATCCC/TAGCTA`	1	--	us2k¹		5		NA WA CSA	127
rs190345615^1,2		--	8272904(+)	`CAGAAC/GTTGCA`	1	--	us2k¹		0	--	--	--	--
rs62126382^1,2	C,F	--	8272916(+)	`TGAGCT/CGAGAT`	1	--	us2k¹		5		NA CSA	128
rs118009034^1,2	F	--	8273585(+)	`CCTCGG/AGCGAA`	1	--	us2k¹		1		EA	120
rs182185688^1,2		--	8273625(+)	`AGACTC/TGGGGT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CERS4 (8271620 - 8327305 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CERS4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CERS4

DNA2.0 Custom Variant and Variant Library Synthesis for CERS4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CERS4 for disorders About GeneDecksing

3 diseases for CERS4: About MalaCards

prostate cancer prostatitis malaria

Export disorders for CERS4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CERS4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CERS4)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Linkage and association of phospholipid transfer prot ein activity to LASS4. (PubMed id 21757428)¹ Rosenthal E.A....Jarvik G.P. (2011)
Inherited genetic variant predisposes to aggressive b ut not indolent prostate cancer. (PubMed id 20080650)¹ Xu J....Isaacs W.B. (2010)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)
The CLN9 protein, a regulator of dihydroceramide synthase. (PubMed id 16303764)⁹ Schulz A....Boustany R.M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79603	HGNC: 23747	AceView: LASS4	Ensembl:ENSG00000090661	euGenes: HUgn79603
ECgene: CERS4	H-InvDB: CERS4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CERS4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CERS4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CERS4 gene:
Search GeneIP for patents involving CERS4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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ceramide synthase 4

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ceramide synthase 4

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for CERS4 gene

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