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CERS4 Gene

protein-coding   GIFtS: 53
GCID: GC19P008276

Ceramide Synthase 4

(Previous names: LAG1 longevity assurance homolog 4 (S. cerevisiae), LAG1...)
(Previous symbol: LASS4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ceramide Synthase 41 2     LAG1 Longevity Assurance Homolog 4 (S. Cerevisiae)1
LASS41 2 3 5     Trh12
LAG1 Homolog, Ceramide Synthase 41 2     CerS43
LAG1 Longevity Assurance Homolog 42 3     TRH15

External Ids:    HGNC: 237471   Entrez Gene: 796032   Ensembl: ENSG000000906617   OMIM: 6153345   UniProtKB: Q9HA823   

Export aliases for CERS4 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CERS4 Gene:
CERS4 (ceramide synthase 4) is a protein-coding gene. GO annotations related to this gene include sphingosine N-acyltransferase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CERS2.

UniProtKB/Swiss-Prot: CERS4_HUMAN, Q9HA82
Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed
in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked
stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CERS4
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CERS4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CERS4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.3

CERS4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CERS4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P008276:  view genomic region     (about GC identifiers)

Start:
8,271,620 bp from pter      End:
8,327,305 bp from pter
Size:
55,686 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CERS4_HUMAN, Q9HA82 (See protein sequence)
Recommended Name: Ceramide synthase 4  
Size: 394 amino acids; 46399 Da
Secondary accessions: D6W665

Explore the universe of human proteins at neXtProt for CERS4: NX_Q9HA82

Explore proteomics data for CERS4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CERS4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078828.2  
    ENSEMBL proteins: 
     ENSP00000453796   ENSP00000453388   ENSP00000452753   ENSP00000452910   ENSP00000251363  
     ENSP00000453509   ENSP00000453815   ENSP00000452920   ENSP00000454122  
    Reactome Protein details: Q9HA82

    CERS4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for CERS4
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    OriGene MassSpec for CERS4
    OriGene Custom Protein Services for CERS4
    GenScript Custom Purified and Recombinant Proteins Services for CERS4
    Novus Biologicals CERS4 Proteins
    Novus Biologicals CERS4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CERS4 

    CERS4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    ThermoFisher Antibodies for CERS4
    LSBio Antibodies in human, mouse, rat for CERS4

    CERS4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CERS4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CERS: Homeoboxes / CERS class

    4 InterPro protein domains:
     IPR016439 Longevity_assurance_LAG1_LAC1
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like
     IPR006634 TLC-dom

    Graphical View of Domain Structure for InterPro Entry Q9HA82

    ProtoNet protein and cluster: Q9HA82

    2 Blocks protein domains:
    IPB005547 Longevity-assurance protein (LAG1)
    IPB006634 TRAM


    UniProtKB/Swiss-Prot: CERS4_HUMAN, Q9HA82
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain


    Find genes that share domains with CERS4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CERS4_HUMAN, Q9HA82
    Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed
    in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked
    stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0050291sphingosine N-acyltransferase activity IEA--
         
    Find genes that share ontologies with CERS4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CERS4:
     Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CERS4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CERS4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CERS4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CERS4

    miRNA
    Products:
        
    miRTarBase miRNAs that target CERS4:
    hsa-mir-9-5p (MIRT021339)

    Block miRNA regulation of human, mouse, rat CERS4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CERS4:
    hsa-miR-339-5p
    SwitchGear 3'UTR luciferase reporter plasmidCERS4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CERS4
    Predesigned siRNA for gene silencing in human, mouse, rat CERS4

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CERS4

    Clone
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    OriGene clones in human, mouse for CERS4 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CERS4
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CERS4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CERS4_HUMAN, Q9HA82: Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane;
    Multi-pass membrane protein (By similarity)

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0031965nuclear membrane IEA--

    Find genes that share ontologies with CERS4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CERS4 About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Sphingolipid de novo biosynthesis0.46
    Sphingolipid metabolism0.61
    Sphingolipid Metabolism0.42
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38


    Find genes that share SuperPaths with CERS4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CERS4
        Sphingolipid Metabolism

    1 Reactome Pathway for CERS4
        Sphingolipid de novo biosynthesis


    2 Kegg Pathways  (Kegg details for CERS4):
        Sphingolipid metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CERS4
    Interactions:

        Search GeneGlobe Interaction Network for CERS4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for CERS4 (Q9HA822, 3 ENSP000002513634) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    OLIG1Q8TAK63, ENSP000003310664I2D: score=1 STRING: ENSP00000331066
    ACER2ENSP000003426094STRING: ENSP00000342609
    SEC62ENSP000003376884STRING: ENSP00000337688
    ACER3ENSP000002785444STRING: ENSP00000278544
    PFDN2ENSP000003569894STRING: ENSP00000356989
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006665sphingolipid metabolic process TAS--
    GO:0030148sphingolipid biosynthetic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046513ceramide biosynthetic process IEA--

    Find genes that share ontologies with CERS4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CERS4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CERS4 gene: 
    NM_024552.2  

    Unigene Cluster for CERS4:

    Ceramide synthase 4
    Hs.515111  [show with all ESTs]
    Unigene Representative Sequence: AK055414
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000561008 ENST00000558268 ENST00000558331(uc002mjg.3 uc002mji.3)
    ENST00000561053 ENST00000559490 ENST00000251363 ENST00000559450 ENST00000559336(uc010dvz.3)
    ENST00000600912 ENST00000595722 ENST00000558501 ENST00000560412 ENST00000558877
    ENST00000557925 ENST00000558302 ENST00000599275
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CERS4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CERS4:
    hsa-miR-339-5p
    SwitchGear 3'UTR luciferase reporter plasmidCERS4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CERS4
    Predesigned siRNA for gene silencing in human, mouse, rat CERS4
    Clone
    Products:
         
    OriGene clones in human, mouse for CERS4 (see all 6)
    OriGene ORF clones in mouse, rat for CERS4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CERS4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS4
    Primer
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    OriGene qPCR primer pairs and template standards for CERS4
    OriGene qSTAR qPCR primer pairs in human, mouse for CERS4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CERS4
      QuantiTect SYBR Green Assays in human, mouse, rat CERS4
      QuantiFast Probe-based Assays in human, mouse, rat CERS4

    Additional mRNA sequence: 

    AK022151.1 AK055414.1 AK222621.1 AK225394.1 BC009828.2 BC063621.1 

    18 DOTS entries:

    DT.75103241  DT.91741576  DT.95113227  DT.97773877  DT.113394  DT.100019238  DT.97782292  DT.100829415 
    DT.95113232  DT.100811526  DT.95336878  DT.100749538  DT.86856887  DT.91741577  DT.91873859  DT.97803812 
    DT.91659967  DT.99959718 

    Selected AceView cDNA sequences (see all 184):

    AW135503 BI490050 BQ059431 BM697971 BQ684050 BU674824 AW440633 BE893168 
    BI822463 CR598338 CR614629 BG695862 CR623019 BM667138 BQ214330 BU149864 
    BM045289 BM927305 BF724636 BM909942 BU838297 BU727939 AK055414 AI951478 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CERS4 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                -     -                       -     -     -     -                                                                     
    SP2:                                -     -           -     -     -     -                                                                                 
    SP3:                                                                                                                                                      
    SP4:                                -                 -     -     -     -                                                                                 
    SP5:                                -     -           -     -     -                                                                                       


    ECgene alternative splicing isoforms for CERS4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CERS4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAGGGCC
    CERS4 Expression
    About this image


    CERS4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Thyroid (Endocrine System)
    CERS4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CERS4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515111
        Custom PCR Arrays for CERS4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CERS4
    OriGene qSTAR qPCR primer pairs in human, mouse for CERS4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CERS4
    QuantiTect SYBR Green Assays in human, mouse, rat CERS4
    QuantiFast Probe-based Assays in human, mouse, rat CERS4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CERS4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cers41 , 5 LAG1 homolog, ceramide synthase 45
    ceramide synthase 41
    76.17(n)1
    69.47(a)1
      8 (2.04 cM)5
    672601  NM_026058.41  NP_080334.31 
     44930265 
    chicken
    (Gallus gallus)
    Aves LOC4200501 ceramide synthase 4-like 60.29(n)
    52.71(a)
      420050  XM_004948648.1  XP_004948705.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cers41 ceramide synthase 4 53.47(n)
    50.51(a)
      100379773  XM_004911055.1  XP_004911112.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003301551 ceramide synthase 2-like 56.77(n)
    50.14(a)
      100330155  XM_005163644.1  XP_005163701.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta schlank6
    schlank
    35(a)
    1 → many
    X(6151701-6161260)
    worm
    (Caenorhabditis elegans)
    Secernentea hyl-16
    hyl-26
    Protein HYL-2 (hyl-2) mRNA, complete cds
    29(a)
    29(a)
    many ↔ many
    many ↔ many
    IV(8540554-8544379) WBGene00002043
    X(4696785-4699461) WBGene00002044


    ENSEMBL Gene Tree for CERS4 (if available)
    TreeFam Gene Tree for CERS4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CERS4 gene
    CERS22  CERS12  CERS62  CERS52  CERS32  
    6 SIMAP similar genes for CERS4 using alignment to 8 protein entries:     CERS4_HUMAN (see all proteins):
    CERS2    CERS3    CERS5    CERS6    LASS5    LASS1

    Find genes that share paralogs with CERS4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CERS4 (see all 1489)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1882303641,2
    --8208262(+) TTTTAA/GTAGAG 1 -- us2k10--------
    rs129823501,2
    C,F--8208316(+) cctcaG/Cgtgat 1 -- us2k1 tfbs33Minor allele frequency- C:0.50NA WA 6
    rs72466171,2
    C,F,A--8208333(+) gcctcG/Agcctc 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1807814611,2
    --8272329(+) CCCAGA/GCTGCA 1 -- us2k10--------
    rs1507616791,2
    --8272546(+) GCCACA/GTTGGC 1 -- us2k10--------
    rs1876094271,2
    --8272641(+) ACCCAC/GCCTCT 1 -- us2k10--------
    rs72538901,2
    C,F--8272775(+) aacatT/Agtgaa 1 -- us2k16Minor allele frequency- A:0.43NA WA CSA EA 246
    rs1999605071,2
    --8272808(+) AAATA-/TATATA 1 -- us2k10--------
    rs621263811,2
    C,F--8272852(+) AATCCC/TAGCTA 1 -- us2k15Minor allele frequency- T:0.43NA WA CSA 127
    rs1903456151,2
    --8272904(+) CAGAAC/GTTGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CERS4 (8271620 - 8327305 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CERS4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469677CNV Loss16826518
    dgv3718n71CNV Loss21882294
    nsv2401CNV Loss18451855
    nsv9664CNV Gain18304495
    dgv3717n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615334    OMIM disorders: --


    Find genes that share disorders with CERS4           About GenesLikeMe


    Export disorders for CERS4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CERS4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CERS4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS. (PubMed id 23538298)1 Hartmann D....GrAPsch S. (amp 2013)
    4. Linkage and association of phospholipid transfer protein activity to LASS4. (PubMed id 21757428)1 Rosenthal E.A....Jarvik G.P. (J. Lipid Res. 2011)
    5. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)1 Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)
    10. The CLN9 protein, a regulator of dihydroceramide synthase. (PubMed id 16303764)9 Schulz A....Boustany R.M. (J. Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79603 HGNC: 23747 AceView: LASS4 Ensembl:ENSG00000090661 euGenes: HUgn79603
    ECgene: CERS4 Kegg: 79603 H-InvDB: CERS4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CERS4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CERS4 gene:
    Search GeneIP for patents involving CERS4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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