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Aliases for CERS4 Gene

Aliases for CERS4 Gene

  • Ceramide Synthase 4 2 3
  • LASS4 3 4 6
  • LAG1 Longevity Assurance Homolog 4 3 4
  • LAG1 Homolog, Ceramide Synthase 4 2 3
  • Trh1 3 6
  • LAG1 Longevity Assurance Homolog 4 (S. Cerevisiae) 2
  • CerS4 4

External Ids for CERS4 Gene

Previous Symbols for CERS4 Gene

  • LASS4

Summaries for CERS4 Gene

GeneCards Summary for CERS4 Gene

CERS4 (Ceramide Synthase 4) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sphingosine N-acyltransferase activity. An important paralog of this gene is CERS5.

UniProtKB/Swiss-Prot for CERS4 Gene

  • May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERS4 Gene

Genomics for CERS4 Gene

Genomic Location for CERS4 Gene

Start:
8,206,736 bp from pter
End:
8,262,421 bp from pter
Size:
55,686 bases
Orientation:
Plus strand

Genomic View for CERS4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CERS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERS4 Gene

No data available for Regulatory Elements for CERS4 Gene

Proteins for CERS4 Gene

  • Protein details for CERS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HA82-CERS4_HUMAN
    Recommended name:
    Ceramide synthase 4
    Protein Accession:
    Q9HA82
    Secondary Accessions:
    • D6W665

    Protein attributes for CERS4 Gene

    Size:
    394 amino acids
    Molecular mass:
    46399 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CERS4 Gene

Proteomics data for CERS4 Gene at MOPED

Post-translational modifications for CERS4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CERS4 Gene

No data available for DME Specific Peptides for CERS4 Gene

Domains for CERS4 Gene

Gene Families for CERS4 Gene

HGNC:
  • CERS :Homeoboxes / CERS class

UniProtKB/Swiss-Prot:

CERS4_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • Q9HA82
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.:
    • Q9HA82
genes like me logo Genes that share domains with CERS4: view

Function for CERS4 Gene

Molecular function for CERS4 Gene

UniProtKB/Swiss-Prot Function: May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).

Gene Ontology (GO) - Molecular Function for CERS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0050291 sphingosine N-acyltransferase activity IBA --
genes like me logo Genes that share ontologies with CERS4: view

Phenotypes for CERS4 Gene

GenomeRNAi human phenotypes for CERS4:
genes like me logo Genes that share phenotypes with CERS4: view

miRNA for CERS4 Gene

miRTarBase miRNAs that target CERS4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CERS4 Gene

Localization for CERS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERS4 Gene

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for CERS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with CERS4: view

Pathways for CERS4 Gene

genes like me logo Genes that share pathways with CERS4: view

Pathways by source for CERS4 Gene

Gene Ontology (GO) - Biological Process for CERS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process TAS --
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046513 ceramide biosynthetic process IBA --
genes like me logo Genes that share ontologies with CERS4: view

Transcripts for CERS4 Gene

Unigene Clusters for CERS4 Gene

Ceramide synthase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CERS4 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - -
SP2: - - - - - -
SP3:
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - - - -
SP7: - - - - -

Relevant External Links for CERS4 Gene

GeneLoc Exon Structure for
CERS4
ECgene alternative splicing isoforms for
CERS4

Expression for CERS4 Gene

mRNA expression in normal human tissues for CERS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CERS4 Gene

SOURCE GeneReport for Unigene cluster for CERS4 Gene Hs.515111

genes like me logo Genes that share expressions with CERS4: view

Orthologs for CERS4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CERS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CERS4 37
  • 98 (a)
OneToOne
LASS4 36
  • 99.07 (n)
  • 98.48 (a)
cow
(Bos Taurus)
Mammalia CERS4 36
  • 78.8 (n)
  • 71.25 (a)
CERS4 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CERS4 36
  • 81 (n)
  • 76.08 (a)
CERS4 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cers4 36
  • 76.17 (n)
  • 69.47 (a)
Cers4 16
Cers4 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 60 (a)
OneToMany
-- 37
  • 52 (a)
OneToMany
-- 37
  • 47 (a)
OneToMany
-- 37
  • 54 (a)
OneToMany
-- 37
  • 52 (a)
OneToMany
-- 37
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CERS4 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cers4 36
  • 77.27 (n)
  • 69.97 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 49 (a)
OneToMany
-- 37
  • 51 (a)
OneToMany
LOC420050 36
  • 60.29 (n)
  • 52.71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cers4 36
  • 53.47 (n)
  • 50.51 (a)
zebrafish
(Danio rerio)
Actinopterygii CERS4 (1 of 2) 37
  • 45 (a)
OneToMany
cers4a 37
  • 44 (a)
OneToMany
LOC100330155 36
  • 56.77 (n)
  • 50.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta schlank 37
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hyl-1 37
  • 29 (a)
ManyToMany
hyl-2 37
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAG1 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 34 (a)
ManyToMany
-- 37
  • 40 (a)
ManyToMany
-- 37
  • 38 (a)
ManyToMany
-- 37
  • 33 (a)
ManyToMany
Species with no ortholog for CERS4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERS4 Gene

ENSEMBL:
Gene Tree for CERS4 (if available)
TreeFam:
Gene Tree for CERS4 (if available)

Paralogs for CERS4 Gene

Paralogs for CERS4 Gene

Selected SIMAP similar genes for CERS4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CERS4: view

Variants for CERS4 Gene

Sequence variations from dbSNP and Humsavar for CERS4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs12891 -- 8,262,312(+) TCTGG(C/G)AGCCA utr-variant-3-prime
rs28133 -- 8,262,618(+) GCCCC(C/T)GACTC downstream-variant-500B
rs28334 -- 8,256,298(+) GGCAG(A/T)GTGTG intron-variant
rs36246 -- 8,255,315(+) AGGGA(C/T)GCAGG intron-variant
rs36247 -- 8,257,062(-) TAGTC(A/G)GAGGA synonymous-codon, reference, stop-lost

Structural Variations from Database of Genomic Variants (DGV) for CERS4 Gene

Variant ID Type Subtype PubMed ID
nsv469677 CNV Loss 16826518
nsv9664 CNV Gain 18304495
dgv3717n71 CNV Gain 21882294
dgv3718n71 CNV Loss 21882294
nsv2401 CNV Loss 18451855

Relevant External Links for CERS4 Gene

HapMap Linkage Disequilibrium report
CERS4

Disorders for CERS4 Gene

No disorders were found for CERS4 Gene.

No data available for UniProtKB/Swiss-Prot for CERS4 Gene

Publications for CERS4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J. … Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3
  5. Linkage and association of phospholipid transfer protein activity to LASS4. (PMID: 21757428) Rosenthal E.A. … Jarvik G.P. (J. Lipid Res. 2011) 3

Products for CERS4 Gene

Sources for CERS4 Gene

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