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Aliases for CERS4 Gene

Aliases for CERS4 Gene

  • Ceramide Synthase 4 2 3 5
  • LAG1 Longevity Assurance Homolog 4 3 4
  • LAG1 Homolog, Ceramide Synthase 4 2 3
  • LASS4 3 4
  • LAG1 Longevity Assurance Homolog 4 (S. Cerevisiae) 2
  • CerS4 4
  • Trh1 3

External Ids for CERS4 Gene

Previous HGNC Symbols for CERS4 Gene

  • LASS4

Previous GeneCards Identifiers for CERS4 Gene

  • GC19P008276

Summaries for CERS4 Gene

GeneCards Summary for CERS4 Gene

CERS4 (Ceramide Synthase 4) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. GO annotations related to this gene include sphingosine N-acyltransferase activity. An important paralog of this gene is CERS2.

UniProtKB/Swiss-Prot for CERS4 Gene

  • May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERS4 Gene

Genomics for CERS4 Gene

Regulatory Elements for CERS4 Gene

Enhancers for CERS4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F008207 1 ENCODE 48.3 +2.5 2473 3.6 HDGF WRNIP1 SIN3A ARID4B DMAP1 ZNF48 SLC30A9 GLIS2 ZNF143 ZNF207 CERS4 ENSG00000271717
GH19F008205 0.2 ENCODE 47.2 -0.2 -184 1.3 ZNF121 ZMYM3 REST CERS4 LOC100422633
GH19F008202 1.3 Ensembl ENCODE 19.4 -2.7 -2656 2.9 PKNOX1 ZBTB40 RAD21 ZNF335 ZNF143 ZNF207 ETV6 CREM THAP11 ZNF362 CERS4 LOC100422633
GH19F008239 0.8 Ensembl ENCODE 13.3 +34.3 34313 3.3 HDGF PKNOX1 ARNT MLX SIN3A ARID4B ZNF2 YY1 CBX5 ZNF416 HNRNPM ELAVL1 ZNF558 XAB2 ZNF414 CERS4 ENSG00000271717 GC19P008268
GH19F008191 0.5 Ensembl ENCODE 10.6 -12.2 -12236 5.4 HDGF PKNOX1 MLX WRNIP1 ARID4B DMAP1 SLC30A9 ZNF143 ZNF207 SP5 CERS4 FBN3 ZNF317 LOC100422633
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CERS4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CERS4 Gene

Chromosome:
19
Start:
8,206,736 bp from pter
End:
8,262,421 bp from pter
Size:
55,686 bases
Orientation:
Plus strand

Genomic View for CERS4 Gene

Genes around CERS4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERS4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERS4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERS4 Gene

Proteins for CERS4 Gene

  • Protein details for CERS4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HA82-CERS4_HUMAN
    Recommended name:
    Ceramide synthase 4
    Protein Accession:
    Q9HA82
    Secondary Accessions:
    • D6W665

    Protein attributes for CERS4 Gene

    Size:
    394 amino acids
    Molecular mass:
    46399 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CERS4 Gene

Post-translational modifications for CERS4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CERS4 Gene

Domains & Families for CERS4 Gene

Gene Families for CERS4 Gene

Suggested Antigen Peptide Sequences for CERS4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HA82

UniProtKB/Swiss-Prot:

CERS4_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
genes like me logo Genes that share domains with CERS4: view

Function for CERS4 Gene

Molecular function for CERS4 Gene

UniProtKB/Swiss-Prot Function:
May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner (By similarity).

Gene Ontology (GO) - Molecular Function for CERS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0050291 sphingosine N-acyltransferase activity TAS --
genes like me logo Genes that share ontologies with CERS4: view
genes like me logo Genes that share phenotypes with CERS4: view

Animal Models for CERS4 Gene

MGI Knock Outs for CERS4:

Animal Model Products

miRNA for CERS4 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CERS4 Gene

Localization for CERS4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERS4 Gene

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CERS4 Gene COMPARTMENTS Subcellular localization image for CERS4 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 3
plasma membrane 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CERS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005783 endoplasmic reticulum IEA,IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CERS4: view

Pathways & Interactions for CERS4 Gene

genes like me logo Genes that share pathways with CERS4: view

Pathways by source for CERS4 Gene

Gene Ontology (GO) - Biological Process for CERS4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0046513 ceramide biosynthetic process IBA --
genes like me logo Genes that share ontologies with CERS4: view

No data available for SIGNOR curated interactions for CERS4 Gene

Drugs & Compounds for CERS4 Gene

(3) Drugs for CERS4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Coenzyme A Nutra 0
genes like me logo Genes that share compounds with CERS4: view

Transcripts for CERS4 Gene

Unigene Clusters for CERS4 Gene

Ceramide synthase 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CERS4 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - - - -
SP2: - - - - - -
SP3:
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - - - -
SP7: - - - - -

Relevant External Links for CERS4 Gene

GeneLoc Exon Structure for
CERS4
ECgene alternative splicing isoforms for
CERS4

Expression for CERS4 Gene

mRNA expression in normal human tissues for CERS4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CERS4 Gene

This gene is overexpressed in Frontal cortex (14.6), Retina (14.3), and Liver (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CERS4 Gene



NURSA nuclear receptor signaling pathways regulating expression of CERS4 Gene:

CERS4

SOURCE GeneReport for Unigene cluster for CERS4 Gene:

Hs.515111
genes like me logo Genes that share expression patterns with CERS4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CERS4 Gene

Orthologs for CERS4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CERS4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LASS4 34
  • 99.07 (n)
CERS4 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CERS4 34 35
  • 81 (n)
cow
(Bos Taurus)
Mammalia CERS4 34 35
  • 78.8 (n)
rat
(Rattus norvegicus)
Mammalia Cers4 34
  • 77.27 (n)
mouse
(Mus musculus)
Mammalia Cers4 34 16 35
  • 76.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CERS4 35
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 60 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC420050 34
  • 60.29 (n)
-- 35
  • 51 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cers4 34
  • 53.47 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100330155 34
  • 56.77 (n)
CERS4 (1 of 2) 35
  • 45 (a)
OneToMany
cers4a 35
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta schlank 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hyl-1 35
  • 29 (a)
ManyToMany
hyl-2 35
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAG1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
Species where no ortholog for CERS4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERS4 Gene

ENSEMBL:
Gene Tree for CERS4 (if available)
TreeFam:
Gene Tree for CERS4 (if available)

Paralogs for CERS4 Gene

Paralogs for CERS4 Gene

(6) SIMAP similar genes for CERS4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CERS4: view

Variants for CERS4 Gene

Sequence variations from dbSNP and Humsavar for CERS4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1007545 -- 8,238,821(+) AGCcc(A/G)agtgt intron-variant
rs1038082 -- 8,213,597(+) gccac(C/T)gtgcc intron-variant
rs10402060 -- 8,249,668(+) CTCAC(C/T)GCAAC intron-variant
rs10405499 -- 8,235,938(+) cgcct(G/T)taatc intron-variant
rs10409603 -- 8,248,689(+) tggat(A/G)gggag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CERS4 Gene

Variant ID Type Subtype PubMed ID
esv3555981 CNV deletion 23714750
nsv2401 CNV deletion 18451855
nsv469677 CNV loss 16826518
nsv472903 CNV novel sequence insertion 20440878
nsv953964 CNV deletion 24416366
nsv9664 CNV gain 18304495

Variation tolerance for CERS4 Gene

Residual Variation Intolerance Score: 40.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.38; 92.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CERS4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CERS4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERS4 Gene

Disorders for CERS4 Gene

Relevant External Links for CERS4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CERS4

No disorders were found for CERS4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CERS4 Gene

Publications for CERS4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region. (PMID: 26887952) Sassa T. … Kihara A. (J. Biol. Chem. 2016) 3 64
  4. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre R.N. … Friedlander Y. (J. Lipid Res. 2015) 3 64
  5. Linking the ceramide synthases (CerSs) 4 and 5 with apoptosis, endometrial and colon cancers. (PMID: 25779024) Mojakgomo R. … Dlamini Z. (Exp. Mol. Pathol. 2015) 3 64

Products for CERS4 Gene

Sources for CERS4 Gene

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