Aliases for CERS3 Gene
External Ids for CERS3 Gene
Previous Symbols for CERS3 Gene
GeneCards Summary for CERS3 Gene
CERS3 (Ceramide Synthase 3) is a Protein Coding gene. Diseases associated with CERS3 include ichthyosis, congenital, autosomal recessive 9 and congenital ichthyosiform erythroderma. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sphingosine N-acyltransferase activity. An important paralog of this gene is CERS5.
UniProtKB/Swiss-Prot for CERS3 Gene
Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs (By similarity). It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation.