Aliases for CERS3 Gene
External Ids for CERS3 Gene
Previous HGNC Symbols for CERS3 Gene
Previous GeneCards Identifiers for CERS3 Gene
GeneCards Summary for CERS3 Gene
CERS3 (Ceramide Synthase 3) is a Protein Coding gene. Diseases associated with CERS3 include ichthyosis, congenital, autosomal recessive 9 and ichthyosis-short stature-brachydactyly-microspherophakia syndrome. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sphingosine N-acyltransferase activity. An important paralog of this gene is CERS5.
UniProtKB/Swiss-Prot for CERS3 Gene
Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs (By similarity). It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation.