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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CERS3 Gene

protein-coding   GIFtS: 47
GCID: GC15M100941

Ceramide Synthase 3

(Previous names: LAG1 longevity assurance homolog 3 (S. cerevisiae), LAG1...)
(Previous symbol: LASS3)
  Search for CERS3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ceramide Synthase 31 2     LAG1 Longevity Assurance Homolog 3 (S. Cerevisiae)1
LASS31 2 3     ARCI92
LAG1 Homolog, Ceramide Synthase 31 2     Dihydroceramide Synthase 32
LAG1 Longevity Assurance Homolog 32 3     CerS33

External Ids:    HGNC: 237521   Entrez Gene: 2042192   Ensembl: ENSG000001542277   OMIM: 6152765   UniProtKB: Q8IU893   

Export aliases for CERS3 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CERS3 Gene: 
CERS3 (ceramide synthase 3) is a protein-coding gene. Among its related super-pathways are Sphingolipid metabolism and Metabolic pathways. GO annotations related to this gene include sphingosine N-acyltransferase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CERS2.

UniProtKB/Swiss-Prot: CERS3_HUMAN, Q8IU89
Function: May be involved in sphingolipid synthesis or its regulation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CERS3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCERS3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CERS3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CERS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

CERS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CERS3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M100941:  view genomic region     (about GC identifiers)

Start:
100,940,600 bp from pter      End:
101,085,200 bp from pter
Size:
144,601 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CERS3_HUMAN, Q8IU89 (See protein sequence)
Recommended Name: Ceramide synthase 3  
Size: 383 amino acids; 46316 Da
Subcellular location: Nucleus membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q8NE64 Q8NEN6

Explore the universe of human proteins at neXtProt for CERS3: NX_Q8IU89

Explore proteomics data for CERS3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IU89

  • CERS3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CERS3 Protein Expression
    REFSEQ proteins: NP_849164.2  
    ENSEMBL proteins: 
     ENSP00000284382   ENSP00000437640   ENSP00000377672   ENSP00000453816   ENSP00000453598  
    Reactome Protein details: Q8IU89
    Human Recombinant Protein Products for CERS3: 
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    Novus Biologicals CERS3 Protein
    Novus Biologicals CERS3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--
    GO:0031965nuclear membrane IEA--

    CERS3 for ontologies           About GeneDecksing



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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CERS: Homeoboxes / CERS class

    4 InterPro protein domains:
     IPR016439 Longevity_assurance_LAG1_LAC1
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like
     IPR006634 TLC-dom

    Graphical View of Domain Structure for InterPro Entry Q8IU89

    ProtoNet protein and cluster: Q8IU89

    2 Blocks protein domains:
    IPB005547 Longevity-assurance protein (LAG1)
    IPB006634 TRAM


    UniProtKB/Swiss-Prot: CERS3_HUMAN, Q8IU89
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain


    CERS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CERS3_HUMAN, Q8IU89
    Function: May be involved in sphingolipid synthesis or its regulation (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0050291sphingosine N-acyltransferase activity IEA--
         
    CERS3 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cers3):
     behavior/neurological  growth/size  homeostasis/metabolism  immune system  integument 
     mortality/aging 

    CERS3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cers3tm1.1Rsnd for CERS3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CERS3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CERS3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CERS3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CERS3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CERS3
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CERS3:
    hsa-miR-338-5p hsa-miR-448 hsa-miR-4251 hsa-miR-539 hsa-miR-3143 hsa-miR-543 hsa-miR-150
    SwitchGear 3'UTR luciferase reporter plasmidCERS3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CERS3
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CERS3

    Clone
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    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CERS3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.63
    Sphingolipid de novo biosynthesis0.47
    Sphingolipid metabolism0.63
    Sphingolipid Metabolism0.42
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CERS3
        Sphingolipid Metabolism

    4        Reactome Pathways for CERS3
        Sphingolipid metabolism
    Metabolism
    Metabolism of lipids and lipoproteins
    Sphingolipid de novo biosynthesis


    2         Kegg Pathways  (Kegg details for CERS3):
        Sphingolipid metabolism
    Metabolic pathways


    CERS3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CERS3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CERS3 (ENSP000002843824) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT3ENSP000003721914STRING: ENSP00000372191
    SIRT5ENSP000003685524STRING: ENSP00000368552
    HDAC6ENSP000003340614STRING: ENSP00000334061
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006665sphingolipid metabolic process TAS--
    GO:0030148sphingolipid biosynthetic process TAS--
    GO:0030216keratinocyte differentiation IMP--
    GO:0044281small molecule metabolic process TAS--

    CERS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CERS3

    Search CenterWatch for drugs/clinical trials and news about CERS3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CERS3 gene: 
    NM_178842.3  

    Unigene Cluster for CERS3:

    Ceramide synthase 3
    Hs.662371  [show with all ESTs]
    Unigene Representative Sequence: BC034970
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284382(uc002bvz.3 uc002bwa.3 uc002bwb.3) ENST00000538112
    ENST00000394113 ENST00000560944 ENST00000560348 ENST00000558884 ENST00000559023
    ENST00000559639
    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate CERS3:
    hsa-miR-338-5p hsa-miR-448 hsa-miR-4251 hsa-miR-539 hsa-miR-3143 hsa-miR-543 hsa-miR-150
    SwitchGear 3'UTR luciferase reporter plasmidCERS3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CERS3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CERS3
    Clone
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    OriGene clones in human, mouse for CERS3 (see all 6)
    OriGene ORF clones in mouse, rat for CERS3
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    GenScript Custom all cDNA clones Services for CERS3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS3
    Sirion Biotech Customized lentivirus for stable overexpression of CERS3 
                         Customized lentivirus expression plasmids for stable overexpression of CERS3 
    Primer
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    OriGene qPCR primer pairs and template standards for CERS3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CERS3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CERS3

    Additional mRNA sequence: 

    AK307191.1 BC027616.2 BC028703.1 BC034500.1 BC034970.1 

    6 DOTS entries:

    DT.91818968  DT.100022188  DT.95265312  DT.40213181  DT.121075538  DT.92044510 

    24/33 AceView cDNA sequences (see all 33):

    AI150300 BG739839 BC034500 AI818996 NM_178842 BC027616 BX109825 BG772599 
    BQ435498 CB857681 BC028703 BC034970 AI091424 BG772055 BG717442 BG743450 
    BX112012 BF980181 BI459140 AA405035 BM559623 BG718327 AA897501 BF979454 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CERS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTTTACT
    CERS3 Expression
    About this image


    See CERS3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CERS3

    SOURCE GeneReport for Unigene cluster: Hs.662371
        SABiosciences Custom PCR Arrays for CERS3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CERS3 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cers35
    Lass31
    LAG1 homolog, ceramide synthase 31, 5 83.07(n)1
    78.53(a)1
      7 (36.15 cM)5
    5459751  NM_001164201.11  NP_001157673.11 
     667435045 
    chicken
    (Gallus gallus)
    Aves CERS31 ceramide synthase 3 66.49(n)
    59.68(a)
      426648  XM_424275.3  XP_424275.2 
    lizard
    (Anolis carolinensis)
    Reptilia CERS36
    Uncharacterized protein
    56(a)
    1 ↔ 1
    GL343383.1(749010-773042)
    African clawed frog
    (Xenopus laevis)
    Amphibia BG363905.12   -- 74.58(n)    BG363905.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01067609.16
    cers36
    ceramide synthase 3
    50(a)
    50(a)
    1 ↔ many
    1 ↔ many
    7(10744380-10783500)
    18(6772525-6789193)
    fruit fly
    (Drosophila melanogaster)
    Insecta schlank6
    schlank
    34(a)
    1 → many
    X(6151701-6161260)
    worm
    (Caenorhabditis elegans)
    Secernentea hyl-26
    hyl-16
    Protein HYL-1
    26(a)
    26(a)
    many ↔ many
    many ↔ many
    X(4697246-4699461)
    IV(8540554-8544379)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes LAG16
    LAC16
    Ceramide synthase component, involved in synthesis...
    Ceramide synthase component, involved in synthesis...
    15(a)
    13(a)
    many ↔ many
    many ↔ many
    VIII(100648-101883)
    XI(427295-428551)


    ENSEMBL Gene Tree for CERS3 (if available)
    TreeFam Gene Tree for CERS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CERS3 gene
    CERS22  CERS42  CERS12  CERS62  CERS52  
    5 SIMAP similar genes for CERS3 using alignment to 4 protein entries:     CERS3_HUMAN (see all proteins):
    CERS2    CERS4    CERS6    LASS5    CERS5

    CERS3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3804 SNPs in CERS3 are shown (see all 3804)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113487391,2
    C--77133433(+) TTGCT-/A/ATCA
            
    TTCTC
    1 -- int10--------
    rs109093911,2
    H--77148249(+) TTTTTA/TAAAAA 1 -- int1 trp30--------
    rs556402051,2
    C--80769826(+) TTTTT-/TTTGAGAT 1 -- int11Minor allele frequency- TTT:0.00NA 2
    rs787877471,2
    C,F--100940159(+) TAGGTC/TATTCT 1 -- ds50011Minor allele frequency- T:0.08WA 118
    rs734707341,2
    C,F--100940285(+) CACAGG/AGTGCA 1 -- ds50013Minor allele frequency- A:0.08WA NA 240
    rs765885471,2
    F--100940304(+) GCTCTC/GCTTAG 1 -- ds50011Minor allele frequency- G:0.08EA 120
    rs597308511,2
    C,F--100940371(+) CCAATC/GAGGCA 1 -- ds50013Minor allele frequency- G:0.09WA CSA 122
    rs18671611,2
    C,F,A,H--100940425(+) ACACCA/GCAAAC 1 -- ds500124Minor allele frequency- G:0.18NS EA NA WA CSA 1345
    rs1399415051,2
    C--100940567(+) CCAAGA/CAATGT 1 -- ds50010--------
    rs734707361,2
    C--100940716(+) AAAGAG/ATGGTT 1 -- ut312Minor allele frequency- A:0.11WA 120

    HapMap Linkage Disequilibrium report for CERS3 (100940600 - 101085200 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/26 variations for CERS3 (see all 26):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2750135CNV Deletion23290073
    esv3492CNV Deletion18987735
    esv1759060CNV Deletion17803354
    esv2674387CNV Deletion23128226
    esv1555633CNV Deletion17803354
    esv2145822CNV Deletion18987734
    esv1058598CNV Deletion17803354
    esv1944504CNV Deletion18987734
    esv990393CNV Deletion20482838
    esv2581646CNV Deletion19546169

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CERS3
    DNA2.0 Custom Variant and Variant Library Synthesis for CERS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CERS3 for disorders           About MalaCards
    OMIM gene information: 615276    OMIM disorders: --


    CERS3 for disorders           About GeneDecksing


    Export disorders for CERS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CERS3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CERS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Mutations in CERS3 cause autosomal recessive congenita l ichthyosis in humans. (PubMed id 23754960)1 Radner F.P....Fischer J. (2013)
    3. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    4. A meta-analysis of four genome-wide association studi es of survival to age 90 years or older: the Cohorts for Heart and Aging Resear ch in Genomic Epidemiology Consortium. (PubMed id 20304771)1 Newman A.B....Murabito J.M. (2010)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 204219 HGNC: 23752 AceView: LASS3 Ensembl:ENSG00000154227 euGenes: HUgn204219
    ECgene: CERS3 Kegg: 204219 H-InvDB: CERS3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CERS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CERS3 gene:
    Search GeneIP for patents involving CERS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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