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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CERS3 Gene

protein-coding GIFtS: 46
GCID: GC15M100941

ceramide synthase 3

(Previous names: LAG1 longevity assurance homolog 3 (S. cerevisiae), LAG1...)
(Previous symbol: LASS3)

Explore 1 disease affiliated with
CERS3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ceramide Synthase 3¹ ²		MGC27091¹
LASS3¹ ² ³		LAG1 Longevity Assurance Homolog 3 (S. Cerevisiae)¹
LAG1 Homolog, Ceramide Synthase 3¹ ²		CerS3³
LAG1 Longevity Assurance Homolog 3² ³

External Ids:	HGNC: 23752¹	Entrez Gene: 204219²	Ensembl: ENSG00000154227⁷	UniProtKB: Q8IU89³

Export aliases for CERS3 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CERS3_HUMAN, Q8IU89

Function: May be involved in sphingolipid synthesis or its regulation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010274.17

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for CERS3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CERS3 promoter sequence

Search SABiosciences Chromatin IP Primers for CERS3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CERS3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3 Ensembl cytogenetic band: 15q26.3 HGNC cytogenetic band: 15q26.3

CERS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CERS3 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M100941: view genomic region (about GC identifiers)

Start:	100,940,600 bp from pter	End:	101,085,200 bp from pter
Size:	144,601 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CERS3_HUMAN, Q8IU89 (See protein sequence)

Recommended Name: Ceramide synthase 3

Size: 383 amino acids; 46316 Da

Subcellular location: Nucleus membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q8NE64 Q8NEN6

Explore the universe of human proteins at neXtProt for CERS3: NX_Q8IU89

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IU89

CERS3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_849164.2

ENSEMBL proteins:

ENSP00000284382 ENSP00000437640 ENSP00000377672 ENSP00000453816 ENSP00000452661

ENSP00000453598

Reactome Protein details: Q8IU89
Human Recombinant Protein Products for CERS3:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Protein: CERS3 OriGene Protein Over-expression Lysate: CERS3 OriGene Custom Protein Services for CERS3
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	Novus Biologicals CERS3 Protein Novus Biologicals CERS3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CERS3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0016021	integral to membrane	IEA	--
GO:0031965	nuclear membrane	IEA	--

CERS3 for ontologies About GeneDecksing

CERS3 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Novus Biologicals CERS3 Antibodies
	Abcam antibodies for CERS3
	Uscn Antibodies for CERS3
	ThermoFisher Antibodies for CERS3

Assay Products for CERS3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CERS3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CERS3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CERS3 for domains About GeneDecksing

4 InterPro domains/families:

IPR016439 Longevity_assurance_LAG1_LAC1

IPR001356 Homeodomain

IPR009057 Homeodomain-like

IPR006634 TLC-dom

Graphical View of Domain Structure for InterPro Entry Q8IU89

ProtoNet protein and cluster: Q8IU89

2 Blocks protein families:

IPB005547 Longevity-assurance protein (LAG1)

IPB006634 TRAM

UniProtKB/Swiss-Prot: CERS3_HUMAN, Q8IU89

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CERS3_HUMAN, Q8IU89

Function: May be involved in sphingolipid synthesis or its regulation (By similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--
GO:0050291	sphingosine N-acyltransferase activity	IEA	--

CERS3 for ontologies About GeneDecksing

Phenotypes:
6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cers3):

behavior/neurological	growth/size	homeostasis/metabolism	immune system	integument
mortality/aging

CERS3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Cers3^tm1.1Rsnd for CERS3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CERS3

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CERS3
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate CERS3:
		hsa-miR-338-5p hsa-miR-448 hsa-miR-4251 hsa-miR-539 hsa-miR-3143 hsa-miR-543 hsa-miR-150
		SwitchGear 3'UTR luciferase reporter plasmid: CERS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CERS3 (see all 4) OriGene shRNA RFP: CERS3 OriGene siRNA: CERS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CERS3
		Sirion Biotech Custom design and validation of potent shRNA sequences against CERS3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CERS3
			Sirion Biotech Customized adenovirus for overexpression of CERS3 Sirion Biotech Customized adenovirus for potent knockdown of CERS3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CERS3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CERS3 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for CERS3
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CERS3
		Search LifeMap BioReagents cell lines for CERS3
		Sirion Biotech Customized stable knockdown cell line services for CERS3 Sirion Biotech Customized inducible knockdown cell line services for CERS3 Sirion Biotech Customized stable overexpressing cell line services for CERS3 Sirion Biotech Customized inducible overexpressing cell line services for CERS3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sphingolipid metabolism

Sphingolipid metabolism

1.00

Sphingolipid de novo biosynthesis

0.46

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for CERS3

	Sphingolipid metabolism
	Metabolism
	Metabolism of lipids and lipoproteins
	Sphingolipid de novo biosynthesis

CERS3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CERS3

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for CERS3 (ENSP00000284382⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SIRT3	ENSP00000372191⁴	STRING: ENSP00000372191
SIRT5	ENSP00000368552⁴	STRING: ENSP00000368552
HDAC6	ENSP00000334061⁴	STRING: ENSP00000334061

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006665	sphingolipid metabolic process	TAS	--
GO:0030148	sphingolipid biosynthetic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

CERS3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CERS3
Search CenterWatch for drugs/clinical trials and news about CERS3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CERS3 gene:

NM_178842.3

Unigene Cluster for CERS3:

Ceramide synthase 3

Hs.662371 [show with all ESTs]

Unigene Representative Sequence: BC034970

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000284382(uc002bvz.3 uc002bwa.3 uc002bwb.3) ENST00000538112

ENST00000394113 ENST00000560944 ENST00000560348 ENST00000558884 ENST00000560233

ENST00000559023 ENST00000559639

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CERS3
		7 QIAGEN miScript miRNA Assays for microRNAs that regulate CERS3:
		hsa-miR-338-5p hsa-miR-448 hsa-miR-4251 hsa-miR-539 hsa-miR-3143 hsa-miR-543 hsa-miR-150
		SwitchGear 3'UTR luciferase reporter plasmid: CERS3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CERS3 (see all 4) OriGene shRNA RFP: CERS3 OriGene siRNA: CERS3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CERS3
		Sirion Biotech Custom design and validation of potent shRNA sequences against CERS3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CERS3 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CERS3 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for CERS3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CERS3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CERS3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CERS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CERS3

Additional cDNA sequence:

AK307191.1 BC027616.2 BC028703.1 BC034500.1 BC034970.1

6 DOTS entries:

DT.91818968 DT.100022188 DT.95265312 DT.40213181 DT.121075538 DT.92044510

24/33 AceView cDNA sequences (see all 33):

AI150300 BG739839 AI091424 BG743450 BG717442 BG772599 BC034970 BI459140

AA897501 BG772055 BQ435498 BX112012 BC027616 BC028703 BF980181 NM_178842

AI818996 AA405035 CB857681 BX109825 BG718327 BC034500 BM559623 BI559361

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CERS3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTTTTACT

About this image

CERS3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Secondary Spermatocyte

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CERS3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CERS3

SOURCE GeneReport for Unigene cluster: Hs.662371

SABiosciences Custom PCR Arrays for CERS3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CERS3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CERS3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CERS3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CERS3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CERS3 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CERS3¹	ceramide synthase 3	66.49(n) 59.68(a)		426648 XM_424275.3 XP_424275.2
lizard (Anolis carolinensis)	Reptilia	CERS3⁶	--	57(a)	1 ↔ 1	GL343383.1(749010-773042)
African clawed frog (Xenopus laevis)	Amphibia	BG363905.1²	--	74.58(n)		BG363905.1
zebrafish (Danio rerio)	Actinopterygii	CABZ01067609.1⁶ zgc:171494⁶	zgc:171494	52(a) 51(a)	1 ↔ many 1 ↔ many	7(10744380-10783500) 18(6772525-6789193)
fruit fly (Drosophila melanogaster)	Insecta	schlank⁶	schlank	33(a)	possible ortholog	X(6151701-6161260)
worm (Caenorhabditis elegans)	Secernentea	hyl-1⁶ hyl-2⁶	Homolog of Yeast Longevity gene family member (hyl... Homolog of Yeast Longevity gene family member (hyl...	24(a) 24(a)	many ↔ many many ↔ many	IV(8540541-8544366) X(4697218-4699433)

ENSEMBL Gene Tree for CERS3 (if available)
TreeFam Gene Tree for CERS3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CERS3 gene

CERS2² CERS4² CERS1² CERS6² CERS5²

5 SIMAP similar genes for CERS3 using alignment to 4 protein entries: CERS3_HUMAN (see all proteins):

CERS2 CERS4 CERS6 CERS5 LASS5

CERS3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs78787747^1,2	C,F	--	100940159(+)	`TAGGTC/TATTCT`	1	--	ds500¹		1		WA	118
rs73470734^1,2	C	--	100940285(+)	`CACAGG/AGTGCA`	1	--	ds500¹		3		WA NA	240
rs76588547^1,2	F	--	100940304(+)	`GCTCTC/GCTTAG`	1	--	ds500¹		1		EA	120
rs59730851^1,2	C,F	--	100940371(+)	`CCAATC/GAGGCA`	1	--	ds500¹		3		WA CSA	122
rs1867161^1,2	C,F,A,H	--	100940425(+)	`ACACCA/GCAAAC`	1	--	ds500¹		24		NS EA NA WA CSA	1345
rs139941505^1,2		--	100940567(+)	`CCAAGA/CAATGT`	1	--	ds500¹		0	--	--	--	--
rs73470736^1,2	C	--	100940716(+)	`AAAGAG/ATGGTT`	1	--	ut3¹		2		WA	120
rs145355994^1,2		--	100940760(+)	`TGTTAC/TAAAAA`	1	--	ut3¹		0	--	--	--	--
rs112540644^1,2	C	--	100940828(+)	`AAATTG/CGTATA`	1	--	ut3¹		2		WA	120
rs78375151^1,2	C,F	--	100940907(+)	`CTTAAG/ACAAGA`	1	--	ut3¹		1		NA	120

HapMap Linkage Disequilibrium report for CERS3 (100940600 - 101085200 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CERS3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CERS3

DNA2.0 Custom Variant and Variant Library Synthesis for CERS3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CERS3 for disorders About GeneDecksing

1 disease for CERS3: About MalaCards

malaria

Export disorders for CERS3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CERS3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CERS3)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)¹ Lin Y.Y....Boeke J.D. (2012)
A meta-analysis of four genome-wide association studi es of survival to age 90 years or older: the Cohorts for Heart and Aging Resear ch in Genomic Epidemiology Consortium. (PubMed id 20304771)¹ Newman A.B....Murabito J.M. (2010)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)² Zody M.C....Nusbaum C. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 204219	HGNC: 23752	AceView: LASS3	Ensembl:ENSG00000154227	euGenes: HUgn204219
ECgene: CERS3	H-InvDB: CERS3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CERS3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CERS3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CERS3 gene:
Search GeneIP for patents involving CERS3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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	OriGene Antibodies for CERS3		OriGene shRNA RFP for CERS3
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CERS3		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CERS3
	OriGene Protein Over-expression Lysate for CERS3		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CERS3		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CERS3		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CERS3
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for CERS3		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CERS3		OriGene Custom Protein Services for CERS3
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CERS3
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CERS3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CERS3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CERS3
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CERS3
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CERS3

	GenScript Custom Purified and Recombinant Proteins Services for CERS3		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CERS3
	GenScript Custom Assay Services for CERS3		GenScript Custom Superior Antibodies Services for CERS3
	GenScript Custom overexpressing Cell Line Services for CERS3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	Antibodies for CERS3
	See all of Abcam's Antibodies, Kits and Proteins for CERS3
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Browse ProSpec Recombinant Proteins

CERS3 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CERS3

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS3

	SwitchGear 3'UTR luciferase reporter plasmids for CERS3
	SwitchGear Promoter luciferase reporter plasmids for CERS3

ThermoFisher Antibodies for CERS3

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CERS3

Sirion Biotech Customized:

	stable knockdown cell line services for CERS3
	inducible knockdown cell line services for CERS3
	design and validation of potent shRNA sequences against CERS3
	adenovirus for potent knockdown of CERS3
	adenovirus for overexpression of CERS3
	stable overexpressing cell line services for CERS3
	inducible overexpressing cell line services for CERS3

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CERS3 gene at Home site.

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CERS3 Gene

ceramide synthase 3

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CERS3 Gene

ceramide synthase 3

Aliasesfor CERS3 gene

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Genomic Viewsfor CERS3 gene

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Protein Domains /Familiesfor CERS3 gene

Functionfor CERS3 gene

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Specialized Databases showing CERS3 gene

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Aliases
for CERS3 gene

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for CERS3 gene

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for CERS3 gene

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for CERS3 gene

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Families
for CERS3 gene

Function
for CERS3 gene

Pathways & Interactions
for CERS3 gene

Drugs & Compounds
for CERS3 gene

Transcripts
for CERS3 gene

Expression
for CERS3 gene

Orthologs
for CERS3 gene

Paralogs
for CERS3 gene

Genomic Variants
for CERS3 gene

Disorders / Diseases
for CERS3 gene

Publications
for CERS3 gene

Intellectual Property
for CERS3 gene

Products
for CERS3 gene