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CERS2 Gene

protein-coding   GIFtS: 51
GCID: GC01M150934

Ceramide Synthase 2

(Previous names: longevity assurance (LAG1, S. cerevisiae) homolog 2, LAG1...)
(Previous symbol: LASS2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ceramide Synthase 21 2     TMSG12 3
LASS21 2 3 5     LAG1 Longevity Assurance Homolog 2 (S. Cerevisiae)1
LAG1 Homolog, Ceramide Synthase 21 2     L32
Longevity Assurance (LAG1, S. Cerevisiae) Homolog 21 2     LAG1 Longevity Assurance 22
Tumor Metastasis-Suppressor Gene 1 Protein2 3     CerS23
SP2602 3     LAG1 Longevity Assurance Homolog 23

External Ids:    HGNC: 140761   Entrez Gene: 299562   Ensembl: ENSG000001434187   OMIM: 6069205   UniProtKB: Q96G233   

Export aliases for CERS2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CERS2 Gene:
This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or
overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a
role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have
been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for CERS2 Gene:
CERS2 (ceramide synthase 2) is a protein-coding gene. GO annotations related to this gene include sphingosine N-acyltransferase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CERS4.

UniProtKB/Swiss-Prot: CERS2_HUMAN, Q96G23
Function: Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis

Gene Wiki entry for CERS2 (LASS2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CERS2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCERS2 promoter sequence
   Search Chromatin IP Primers for CERS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CERS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

CERS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CERS2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M150934:  view genomic region     (about GC identifiers)

Start:
150,933,059 bp from pter      End:
150,947,479 bp from pter
Size:
14,421 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CERS2_HUMAN, Q96G23 (See protein sequence)
Recommended Name: Ceramide synthase 2  
Size: 380 amino acids; 44876 Da
Subunit: Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR
Sequence caution: Sequence=BAA91505.1; Type=Erroneous initiation;
Secondary accessions: D3DV06 Q5SZE5 Q9HD96 Q9NW79

Explore the universe of human proteins at neXtProt for CERS2: NX_Q96G23

Explore proteomics data for CERS2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys93, Lys96
  • Glycosylation2 at Asn19
  • Modification sites at PhosphoSitePlus

  • See CERS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_071358.1  NP_859530.1  

    ENSEMBL proteins: 
     ENSP00000454160   ENSP00000453297   ENSP00000357950   ENSP00000357945   ENSP00000355020  
     ENSP00000452810   ENSP00000393239   ENSP00000394012   ENSP00000271688  
    Reactome Protein details: Q96G23

    CERS2 Human Recombinant Protein Products:

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    Novus Biologicals CERS2 Protein
    Novus Biologicals CERS2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CERS2 

    CERS2 Antibody Products:

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    CERS2 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CERS2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CERS: Homeoboxes / CERS class

    4 InterPro protein domains:
     IPR016439 Longevity_assurance_LAG1_LAC1
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like
     IPR006634 TLC-dom

    Graphical View of Domain Structure for InterPro Entry Q96G23

    ProtoNet protein and cluster: Q96G23

    2 Blocks protein domains:
    IPB005547 Longevity-assurance protein (LAG1)
    IPB006634 TRAM


    UniProtKB/Swiss-Prot: CERS2_HUMAN, Q96G23
    Similarity: Contains 1 homeobox DNA-binding domain
    Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain


    Find genes that share domains with CERS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CERS2_HUMAN, Q96G23
    Function: Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI11543633
    GO:0043565sequence-specific DNA binding IEA--
    GO:0050291sphingosine N-acyltransferase activity IEA--
         
    Find genes that share ontologies with CERS2           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cers2):
     homeostasis/metabolism  integument  nervous system  tumorigenesis 

    Find genes that share phenotypes with CERS2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CERS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CERS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CERS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CERS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CERS2:
    hsa-mir-101-3p (MIRT027344), hsa-mir-124-3p (MIRT002726), hsa-mir-1 (MIRT002754), hsa-mir-625-5p (MIRT039594), hsa-mir-221-3p (MIRT006917), hsa-mir-20a-5p (MIRT050621), hsa-mir-9-5p (MIRT021462), hsa-mir-222-3p (MIRT006918), hsa-mir-133a-3p (MIRT021707), hsa-mir-93-5p (MIRT028158)

    Block miRNA regulation of human, mouse, rat CERS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CERS2 (see all 39):
    hsa-miR-4307 hsa-miR-642a hsa-let-7d hsa-miR-650 hsa-let-7g hsa-miR-9 hsa-miR-124 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidCERS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CERS2
    Predesigned siRNA for gene silencing in human, mouse, rat CERS2

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for CERS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CERS2
    Sino Biological Human cDNA Clone for CERS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CERS2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CERS2_HUMAN, Q96G23: Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane;
    Multi-pass membrane protein (By similarity)

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0031965nuclear membrane IDA--

    Find genes that share ontologies with CERS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CERS2 About    
    See pathways by source

    SuperPathContained pathways About
    1Sphingolipid metabolism
    Sphingolipid metabolism0.61
    Sphingolipid de novo biosynthesis0.46
    Sphingolipid metabolism0.61
    Sphingolipid Metabolism0.42
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38


    Find genes that share SuperPaths with CERS2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CERS2
        Sphingolipid Metabolism


    1 Reactome Pathway for CERS2
        Sphingolipid de novo biosynthesis


    2 Kegg Pathways  (Kegg details for CERS2):
        Sphingolipid metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CERS2
    Interactions:

        Search GeneGlobe Interaction Network for CERS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CERS2 (Q96G231, 3 ENSP000002716884) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASGR1P073061, 3, ENSP000002692994EBI-1057080,EBI-1172335 I2D: score=3 STRING: ENSP00000269299
    HSP90AA1P079001, 3EBI-1057080,EBI-296047 I2D: score=1 
    ASGR2P073071, 3, ENSP000003471404EBI-1057080,EBI-1172636 I2D: score=3 STRING: ENSP00000347140
    ATP6V0CP274491, 3, ENSP000003297574EBI-1057080,EBI-721179 I2D: score=3 STRING: ENSP00000329757
    SLC22A1O152451, 3, ENSP000003559304EBI-1057080,EBI-1172714 I2D: score=3 STRING: ENSP00000355930
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006665sphingolipid metabolic process TAS--
    GO:0030148sphingolipid biosynthetic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:0046513ceramide biosynthetic process IEA--

    Find genes that share ontologies with CERS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CERS2

    1 Novoseek inferred chemical compound relationship for CERS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    maleimide 80.3 2 15796876 (1), 15672611 (1)



    Find genes that share compounds with CERS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CERS2 gene (3 alternative transcripts): 
    NM_022075.4  NM_181746.3  NM_013384.3  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482825 ENST00000561294 ENST00000560793 ENST00000345896 ENST00000368954(uc001evz.3 uc009wmh.3)
    ENST00000460664 ENST00000368949 ENST00000361419 ENST00000559660 ENST00000558062
    ENST00000559020 ENST00000421609 ENST00000457392 ENST00000271688(uc001evy.3)

    miRNA
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    Block miRNA regulation of human, mouse, rat CERS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CERS2 (see all 39):
    hsa-miR-4307 hsa-miR-642a hsa-let-7d hsa-miR-650 hsa-let-7g hsa-miR-9 hsa-miR-124 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidCERS2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CERS2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CERS2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS2
    Primer
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    OriGene qPCR primer pairs and template standards for CERS2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CERS2
      QuantiTect SYBR Green Assays in human, mouse, rat CERS2
      QuantiFast Probe-based Assays in human, mouse, rat CERS2

    Selected AceView cDNA sequences (see all 480):

    BM021887 NM_181746 BM908154 BU860297 AU120413 AI061649 BM802619 BU734832 
    BU170936 CD107846 BU164844 BI258752 NM_013384 BM272751 BQ219926 BI028067 
    BQ225616 AK001105 AA345236 NM_022075 BM472770 BQ878340 CD675166 BM461785 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CERS2 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a ·
    SP1:                    -     -     -     -     -                                                     -                 -                 -                     
    SP2:                    -     -     -     -     -     -                                               -                 -                 -                     
    SP3:                                      -     -                                                     -                 -                 -                     
    SP4:                    -     -     -     -                                                           -                 -                                       
    SP5:                                -     -     -                                                     -                                                         

    ExUns: 12b ^ 13a · 13b · 13c ^ 14 ^ 15
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for CERS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CERS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAATAAGTG
    CERS2 Expression
    About this image


    CERS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    CERS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CERS2 Protein Expression

    UniProtKB/Swiss-Prot: CERS2_HUMAN, Q96G23
    Tissue specificity: Expressed in kidney, liver, brain, heart, placenta and lung

        Custom PCR Arrays for CERS2
    Primer
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    QuantiTect SYBR Green Assays in human, mouse, rat CERS2
    QuantiFast Probe-based Assays in human, mouse, rat CERS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CERS2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cers21 , 5 LAG1 homolog, ceramide synthase 25
    ceramide synthase 21
    90.88(n)1
    92.37(a)1
      3 (40.74 cM)5
    768931  NM_029789.11  NP_084065.11 
     953147925 
    chicken
    (Gallus gallus)
    Aves LOC1008572621 ceramide synthase 2-like 78.72(n)
    82.45(a)
      100857262  XM_003642682.2  XP_003642730.2 
    lizard
    (Anolis carolinensis)
    Reptilia CERS26
    ceramide synthase 2
    78(a)
    1 ↔ 1
    GL343893.1(124535-141147)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC042311.12   -- 69.3(n)    BC042311.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trh32 trh3 protein 75.95(n)   259251  BC045284.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta schlank6
    schlank
    36(a)
    1 → many
    X(6151701-6161260)
    worm
    (Caenorhabditis elegans)
    Secernentea hyl-16
    hyl-26
    Protein HYL-2 (hyl-2) mRNA, complete cds
    30(a)
    29(a)
    many ↔ many
    many ↔ many
    IV(8540554-8544379) WBGene00002043
    X(4696785-4699461) WBGene00002044
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons LAG131 LAG13 46.54(n)
    40.09(a)
      837919  NM_001035960.1  NP_001031037.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05813001 Os02g0581300 45.3(n)
    35.45(a)
      4329785  NM_001053779.1  NP_001047244.1 


    ENSEMBL Gene Tree for CERS2 (if available)
    TreeFam Gene Tree for CERS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CERS2 gene
    CERS42  CERS12  CERS62  CERS52  CERS32  
    5 SIMAP similar genes for CERS2 using alignment to 9 protein entries:     CERS2_HUMAN (see all proteins):
    CERS3    CERS4    CERS6    CERS5    LASS5

    Find genes that share paralogs with CERS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CERS2 (see all 248)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs85441,2
    C,F,A,H--150937771(-) tttttT/Aaaaat 2 -- ut3110Minor allele frequency- A:0.01MN NA WA EA 560
    rs763691831,2
    F--150937813(+) TGGTCC/TCTCTG 2 -- ut311Minor allele frequency- T:0.01WA 118
    rs94360171,2
    C,H--150937818(+) CCTCTG/ACTGAA 2 -- ut31 ese34Minor allele frequency- A:0.00NS EA 420
    rs38356651,2
    C--150937965(-) CTCCTCCT/-TTCTC 2 -- cds11Minor allele frequency- -:0.50NA 2
    rs1118943801,2
    C--150937967(+) GAAAGA/C/GAGGAG 4 -- ut311CSA 1
    rs2004056781,2
    --150937972(+) GAGGA-/GGCAGTCA 2 -- cds10--------
    rs1890984641,2
    C--150937980(+) AGTCAG/TATCTT 2 -- ut310--------
    rs1145613811,2
    C,F--150937990(+) TAGACC/ATGTCG 2 -- ut311Minor allele frequency- A:0.04WA 118
    rs1924156031,2
    --150938003(+) ACAGGG/TACAGC 2 -- ut310--------
    rs1461270851,2
    C--150938023(+) TAGCAC/TTAAGA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CERS2 (150933059 - 150947479 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CERS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522317CNV Loss19592680
    nsv522840CNV Gain19592680

    Human Gene Mutation Database (HGMD): CERS2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CERS2
    DNA2.0 Custom Variant and Variant Library Synthesis for CERS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606920    OMIM disorders: --


    Find genes that share disorders with CERS2           About GenesLikeMe

    3 Novoseek inferred disease relationships for CERS2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 26.6 10 18759044 (3), 15672611 (3), 15796876 (1)
    cancer 11.3 5 15672611 (2), 15796876 (1)
    tumors 4.65 14 15796876 (3), 18759044 (3), 15672611 (3)


    Export disorders for CERS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CERS2 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with CERS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PubMed id 11543633)1, 2, 3, 9 Pan H....Gu J.-R. (Genomics 2001)
    2. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. (PubMed id 20937905)1, 2 Ohno Y.... Kihara A. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    3. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)1, 2 Lewandrowski U.... Sickmann A. (Mol. Cell. Proteomics 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS. (PubMed id 23538298)1 Hartmann D....GrAPsch S. (amp 2013)
    8. A novel tumor metastasis suppressor gene LASS2/TMSG1 interacts with vacuolar ATPase through its homeodomain. (PubMed id 22991218)1 Yu W....Pei F. (J. Cell. Biochem. 2013)
    9. LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump. (PubMed id 22580606)1 Fan S....Qin W. (Oncogene 2013)
    10. Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models. (PubMed id 23690971)1 Petrache I....Futerman A.H. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29956 HGNC: 14076 AceView: LASS2 Ensembl:ENSG00000143418 euGenes: HUgn29956
    ECgene: CERS2 Kegg: 29956 H-InvDB: CERS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CERS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CERS2 gene:
    Search GeneIP for patents involving CERS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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