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Set Analyses:

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CERS2 Gene

protein-coding GIFtS: 51
GCID: GC01M150934

Ceramide Synthase 2

(Previous names: longevity assurance (LAG1, S. cerevisiae) homolog 2, LAG1...)
(Previous symbol: LASS2)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Ceramide Synthase 2¹ ²		TMSG1² ³
LASS2¹ ² ³ ⁵		LAG1 Longevity Assurance Homolog 2 (S. Cerevisiae)¹
LAG1 Homolog, Ceramide Synthase 2¹ ²		L3²
Longevity Assurance (LAG1, S. Cerevisiae) Homolog 2¹ ²		LAG1 Longevity Assurance 2²
Tumor Metastasis-Suppressor Gene 1 Protein² ³		CerS2³
SP260² ³		LAG1 Longevity Assurance Homolog 2³

External Ids:	HGNC: 14076¹	Entrez Gene: 29956²	Ensembl: ENSG00000143418⁷	OMIM: 606920⁵	UniProtKB: Q96G23³

Export aliases for CERS2 gene to outside databases

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CERS2 Gene:

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or

overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a

role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have

been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for CERS2 Gene:

CERS2 (ceramide synthase 2) is a protein-coding gene. Diseases associated with CERS2 include retinal detachment, and bladder carcinoma. GO annotations related to this gene include sphingosine N-acyltransferase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CERS4.

UniProtKB/Swiss-Prot: CERS2_HUMAN, Q96G23

Function: Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis

Gene Wiki entry for CERS2 (LASS2) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Search for regulatory transcription factor binding sites for CERS2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CERS2 promoter sequence

Search Chromatin IP Primers for CERS2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CERS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3

CERS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CERS2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M150934: view genomic region (about GC identifiers)

Start:	150,933,059 bp from pter	End:	150,947,479 bp from pter
Size:	14,421 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CERS2_HUMAN, Q96G23 (See protein sequence)

Recommended Name: Ceramide synthase 2

Size: 380 amino acids; 44876 Da

Subunit: Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR

Sequence caution: Sequence=BAA91505.1; Type=Erroneous initiation;

Secondary accessions: D3DV06 Q5SZE5 Q9HD96 Q9NW79

Explore the universe of human proteins at neXtProt for CERS2: NX_Q96G23

Explore proteomics data for CERS2 at MOPED

Post-translational modifications:

Ubiquitination² at Lys93, Lys96

Glycosylation² at Asn19

Modification sites at PhosphoSitePlus

See CERS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_071358.1 NP_859530.1

ENSEMBL proteins:

ENSP00000454160 ENSP00000453297 ENSP00000357950 ENSP00000357945 ENSP00000355020

ENSP00000452810 ENSP00000393239 ENSP00000394012 ENSP00000271688

Reactome Protein details: Q96G23

CERS2 Human Recombinant Protein Products:

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	Novus Biologicals CERS2 Protein Novus Biologicals CERS2 Lysates
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	Browse Proteins at Cloud-Clone Corp.

CERS2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Search for Antibodies for CERS2 at Abcam
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	ThermoFisher Antibodies for CERS2
	LSBio Antibodies in human, mouse, rat for CERS2

CERS2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CERS2
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	GenScript Custom Assay Services for CERS2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

CERS: Homeoboxes / CERS class

4 InterPro protein domains:

IPR016439 Longevity_assurance_LAG1_LAC1

IPR001356 Homeobox_dom

IPR009057 Homeodomain-like

IPR006634 TLC-dom

Graphical View of Domain Structure for InterPro Entry Q96G23

ProtoNet protein and cluster: Q96G23

2 Blocks protein domains:

IPB005547 Longevity-assurance protein (LAG1)

IPB006634 TRAM

UniProtKB/Swiss-Prot: CERS2_HUMAN, Q96G23

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain

CERS2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: CERS2_HUMAN, Q96G23

Function: Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis

Gene Ontology (GO): 5 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	11543633
GO:0043565	sequence-specific DNA binding	IEA	--
GO:0050291	sphingosine N-acyltransferase activity	IEA	--

CERS2 for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cers2):

homeostasis/metabolism

integument

nervous system

tumorigenesis

CERS2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CERS2

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CERS2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CERS2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CERS2

miRNA Products:		miRTarBase miRNAs that target CERS2: hsa-mir-101-3p (MIRT027344), hsa-mir-124-3p (MIRT002726), hsa-mir-1 (MIRT002754), hsa-mir-625-5p (MIRT039594), hsa-mir-221-3p (MIRT006917), hsa-mir-20a-5p (MIRT050621), hsa-mir-9-5p (MIRT021462), hsa-mir-222-3p (MIRT006918), hsa-mir-133a-3p (MIRT021707), hsa-mir-93-5p (MIRT028158)

		Block miRNA regulation of human, mouse, rat CERS2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CERS2 (see all 39):
		hsa-miR-4307 hsa-miR-642a hsa-let-7d hsa-miR-650 hsa-let-7g hsa-miR-9 hsa-miR-124 hsa-miR-149

		SwitchGear 3'UTR luciferase reporter plasmid: CERS2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CERS2
		Predesigned siRNA for gene silencing in human, mouse, rat CERS2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CERS2

Clone Products:		OriGene clones in human, mouse for CERS2 (see all 13) OriGene ORF clones in mouse, rat for CERS2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for CERS2
		Sino Biological Human cDNA Clone for CERS2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CERS2
		Browse ESI BIO Cell Lines and PureStem Progenitors for CERS2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

CERS2_HUMAN, Q96G23: Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane;

Multi-pass membrane protein (By similarity)

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0016021	integral component of membrane	IEA	--
GO:0031965	nuclear membrane	IDA	--

CERS2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CERS2 About

See pathways by source

SuperPath

Contained pathways About

Sphingolipid metabolism

	Sphingolipid metabolism	0.61			Sphingolipid de novo biosynthesis	0.46
	Sphingolipid metabolism	0.61			Sphingolipid Metabolism	0.42

Metabolism

	Metabolism	0.38			Metabolism of lipids and lipoproteins	0.37
	Metabolic pathways	0.38

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for CERS2

Sphingolipid Metabolism

1 Reactome Pathway for CERS2

Sphingolipid de novo biosynthesis

2 Kegg Pathways (Kegg details for CERS2):

	Sphingolipid metabolism
	Metabolic pathways

CERS2 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for CERS2
Interactions:

Search GeneGlobe Interaction Network for CERS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CERS2 (Q96G23^{1, 3} ENSP00000271688⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 84)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ASGR1	P07306¹^,³, ENSP00000269299⁴	EBI-1057080,EBI-1172335 I2D: score=3 STRING: ENSP00000269299
HSP90AA1	P07900¹^,³	EBI-1057080,EBI-296047 I2D: score=1
ASGR2	P07307¹^,³, ENSP00000347140⁴	EBI-1057080,EBI-1172636 I2D: score=3 STRING: ENSP00000347140
ATP6V0C	P27449¹^,³, ENSP00000329757⁴	EBI-1057080,EBI-721179 I2D: score=3 STRING: ENSP00000329757
SLC22A1	O15245¹^,³, ENSP00000355930⁴	EBI-1057080,EBI-1172714 I2D: score=3 STRING: ENSP00000355930

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Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0006665	sphingolipid metabolic process	TAS	--
GO:0030148	sphingolipid biosynthetic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0046513	ceramide biosynthetic process	IEA	--

CERS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CERS2

1 Novoseek inferred chemical compound relationship for CERS2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
maleimide	80.3	2	15796876 (1), 15672611 (1)

CERS2 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CERS2 gene (3 alternative transcripts):

NM_022075.4 NM_181746.3 NM_013384.3

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000482825 ENST00000561294 ENST00000560793 ENST00000345896 ENST00000368954(uc001evz.3 uc009wmh.3)

ENST00000460664 ENST00000368949 ENST00000361419 ENST00000559660 ENST00000558062

ENST00000559020 ENST00000421609 ENST00000457392 ENST00000271688(uc001evy.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat CERS2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CERS2 (see all 39):
		hsa-miR-4307 hsa-miR-642a hsa-let-7d hsa-miR-650 hsa-let-7g hsa-miR-9 hsa-miR-124 hsa-miR-149

		SwitchGear 3'UTR luciferase reporter plasmid: CERS2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CERS2
		Predesigned siRNA for gene silencing in human, mouse, rat CERS2

Clone Products:		OriGene clones in human, mouse for CERS2 (see all 13) OriGene ORF clones in mouse, rat for CERS2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for CERS2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS2

Primer Products:		OriGene qPCR primer pairs and template standards for CERS2 OriGene qSTAR qPCR primer pairs in human, mouse for CERS2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CERS2
		QuantiTect SYBR Green Assays in human, mouse, rat CERS2
		QuantiFast Probe-based Assays in human, mouse, rat CERS2

Selected AceView cDNA sequences (see all 480):

BM021887 NM_181746 BM908154 BU860297 AU120413 AI061649 BM802619 BU734832

BU170936 CD107846 BU164844 BI258752 NM_013384 BM272751 BQ219926 BI028067

BQ225616 AK001105 AA345236 NM_022075 BM472770 BQ878340 CD675166 BM461785

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CERS2 (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	·	9c	·	9d	^	10a	·	10b	^	11a	·	11b	·	11c	^	12a	·
SP1:							-		-		-		-		-																		-						-						-
SP2:							-		-		-		-		-		-																-						-						-
SP3:													-		-																		-						-						-
SP4:							-		-		-		-																				-						-
SP5:											-		-		-																		-

ExUns:	12b	^	13a	·	13b	·	13c	^	14	^	15
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CERS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CERS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCAATAAGTG

About this image

CERS2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 19) fully expand


Brain (Nervous System)
Cerebral Cortex

Bone (Muscoskeletal System)
Bone Marrow

Colon (Gastrointestinal Tract)

Uterus (Reproductive System)

Thyroid (Endocrine System)

CERS2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CERS2 Protein Expression

UniProtKB/Swiss-Prot: CERS2_HUMAN, Q96G23

Tissue specificity: Expressed in kidney, liver, brain, heart, placenta and lung

Custom PCR Arrays for CERS2

Primer Products:		OriGene qPCR primer pairs and template standards for CERS2 OriGene qSTAR qPCR primer pairs in human, mouse for CERS2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat CERS2
		QuantiTect SYBR Green Assays in human, mouse, rat CERS2
		QuantiFast Probe-based Assays in human, mouse, rat CERS2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for CERS2 gene from Selected species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cers2^{1 , 5}	LAG1 homolog, ceramide synthase 2⁵ ceramide synthase 2¹	90.88(n)¹ 92.37(a)¹		3 (40.74 cM)⁵ 76893¹ NM_029789.1¹ NP_084065.1¹ 95314792⁵
chicken (Gallus gallus)	Aves	LOC100857262¹	ceramide synthase 2-like	78.72(n) 82.45(a)		100857262 XM_003642682.2 XP_003642730.2
lizard (Anolis carolinensis)	Reptilia	CERS2⁶	ceramide synthase 2	78(a)	1 ↔ 1	GL343893.1(124535-141147)
African clawed frog (Xenopus laevis)	Amphibia	BC042311.1²	--	69.3(n)		BC042311.1
zebrafish (Danio rerio)	Actinopterygii	trh3²	trh3 protein	75.95(n)		259251 BC045284.1
fruit fly (Drosophila melanogaster)	Insecta	schlank⁶	schlank	36(a)	1 → many	X(6151701-6161260)
worm (Caenorhabditis elegans)	Secernentea	hyl-1⁶ hyl-2⁶	Protein HYL-2 (hyl-2) mRNA, complete cds	30(a) 29(a)	many ↔ many many ↔ many	IV(8540554-8544379) WBGene00002043 X(4696785-4699461) WBGene00002044
thale cress (Arabidopsis thaliana)	eudicotyledons	LAG13¹	LAG13	46.54(n) 40.09(a)		837919 NM_001035960.1 NP_001031037.1
rice (Oryza sativa)	Liliopsida	Os02g0581300¹	Os02g0581300	45.3(n) 35.45(a)		4329785 NM_001053779.1 NP_001047244.1

ENSEMBL Gene Tree for CERS2 (if available)
TreeFam Gene Tree for CERS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CERS2 gene

CERS4² CERS1² CERS6² CERS5² CERS3²

5 SIMAP similar genes for CERS2 using alignment to 9 protein entries: CERS2_HUMAN (see all proteins):

CERS3 CERS4 CERS6 CERS5 LASS5

CERS2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs8544^1,2	C,F,A,H	--	150937771(-)	`tttttT/Aaaaat`	2	--	ut3¹		10		MN NA WA EA	560
rs76369183^1,2	F	--	150937813(+)	`TGGTCC/TCTCTG`	2	--	ut3¹		1		WA	118
rs9436017^1,2	C,H	--	150937818(+)	`CCTCTG/ACTGAA`	2	--	ut3¹ ese³		4		NS EA	420
rs3835665^1,2	C	--	150937965(-)	`CTCCTCCT/-TTCTC`	2	--	cds¹		1		NA	2
rs111894380^1,2	C	--	150937967(+)	`GAAAGA/C/GAGGAG`	4	--	ut3¹		1		CSA	1
rs200405678^1,2		--	150937972(+)	`GAGGA-/GGCAGTCA`	2	--	cds¹		0	--	--	--	--
rs189098464^1,2	C	--	150937980(+)	`AGTCAG/TATCTT`	2	--	ut3¹		0	--	--	--	--
rs114561381^1,2	C,F	--	150937990(+)	`TAGACC/ATGTCG`	2	--	ut3¹		1		WA	118
rs192415603^1,2		--	150938003(+)	`ACAGGG/TACAGC`	2	--	ut3¹		0	--	--	--	--
rs146127085^1,2	C	--	150938023(+)	`TAGCAC/TTAAGA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CERS2 (150933059 - 150947479 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for CERS2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv522317	CNV	Loss	19592680
nsv522840	CNV	Gain	19592680

Human Gene Mutation Database (HGMD): CERS2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 606920 OMIM disorders: --

7 diseases for CERS2:
About MalaCards

retinal detachment bladder carcinoma kidney disease prostate cancer

prostatitis retinitis breast cancer

CERS2 for disorders About GeneDecksing

3 Novoseek inferred disease relationships for CERS2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	26.6	10	18759044 (3), 15672611 (3), 15796876 (1)
cancer	11.3	5	15672611 (2), 15796876 (1)
tumors	4.65	14	15796876 (3), 18759044 (3), 15672611 (3)

Export disorders for CERS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CERS2 gene, integrated from 10 sources (see all 48):
(articles sorted by number of sources associating them with CERS2)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PubMed id 11543633)^{1, 2, 3, 9} Pan H....Gu J.-R. (Genomics 2001)
ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. (PubMed id 20937905)^{1, 2} Ohno Y.... Kihara A. (Proc. Natl. Acad. Sci. U.S.A. 2010)
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)^{1, 2} Lewandrowski U.... Sickmann A. (Mol. Cell. Proteomics 2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS. (PubMed id 23538298)¹ Hartmann D....GrAPsch S. (amp 2013)
A novel tumor metastasis suppressor gene LASS2/TMSG1 interacts with vacuolar ATPase through its homeodomain. (PubMed id 22991218)¹ Yu W....Pei F. (J. Cell. Biochem. 2013)
LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump. (PubMed id 22580606)¹ Fan S....Qin W. (Oncogene 2013)
Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models. (PubMed id 23690971)¹ Petrache I....Futerman A.H. (PLoS ONE 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 29956	HGNC: 14076	AceView: LASS2	Ensembl:ENSG00000143418	euGenes: HUgn29956
ECgene: CERS2	Kegg: 29956	H-InvDB: CERS2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CERS2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CERS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CERS2 gene:
Search GeneIP for patents involving CERS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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