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Aliases for CERS2 Gene

Aliases for CERS2 Gene

  • Ceramide Synthase 2 2 3
  • LASS2 3 4 6
  • Longevity Assurance (LAG1, S. Cerevisiae) Homolog 2 2 3
  • Tumor Metastasis-Suppressor Gene 1 Protein 3 4
  • LAG1 Homolog, Ceramide Synthase 2 2 3
  • SP260 3 4
  • TMSG1 3 4
  • LAG1 Longevity Assurance Homolog 2 (S. Cerevisiae) 2
  • LAG1 Longevity Assurance Homolog 2 4
  • LAG1 Longevity Assurance 2 3
  • CerS2 4
  • L3 3

External Ids for CERS2 Gene

Previous HGNC Symbols for CERS2 Gene

  • LASS2

Summaries for CERS2 Gene

Entrez Gene Summary for CERS2 Gene

  • This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CERS2 Gene

CERS2 (Ceramide Synthase 2) is a Protein Coding gene. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sphingosine N-acyltransferase activity. An important paralog of this gene is CERS5.

UniProtKB/Swiss-Prot for CERS2 Gene

  • Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis

Gene Wiki entry for CERS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERS2 Gene

Genomics for CERS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CERS2 Gene

Start:
150,960,583 bp from pter
End:
150,975,004 bp from pter
Size:
14,422 bases
Orientation:
Minus strand

Genomic View for CERS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CERS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERS2 Gene

No data available for Regulatory Elements for CERS2 Gene

Proteins for CERS2 Gene

  • Protein details for CERS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G23-CERS2_HUMAN
    Recommended name:
    Ceramide synthase 2
    Protein Accession:
    Q96G23
    Secondary Accessions:
    • D3DV06
    • Q5SZE5
    • Q9HD96
    • Q9NW79

    Protein attributes for CERS2 Gene

    Size:
    380 amino acids
    Molecular mass:
    44876 Da
    Quaternary structure:
    • Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR.
    SequenceCaution:
    • Sequence=BAA91505.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CERS2 Gene

Proteomics data for CERS2 Gene at MOPED

Post-translational modifications for CERS2 Gene

  • Ubiquitination at Lys93 and Lys96
  • Glycosylation at Asn19
  • Modification sites at PhosphoSitePlus

Other Protein References for CERS2 Gene

No data available for DME Specific Peptides for CERS2 Gene

Domains for CERS2 Gene

Gene Families for CERS2 Gene

HGNC:
  • CERS :Homeoboxes / CERS class

Graphical View of Domain Structure for InterPro Entry

Q96G23

UniProtKB/Swiss-Prot:

CERS2_HUMAN :
  • Q96G23
Domain:
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
genes like me logo Genes that share domains with CERS2: view

No data available for Suggested Antigen Peptide Sequences for CERS2 Gene

Function for CERS2 Gene

Molecular function for CERS2 Gene

UniProtKB/Swiss-Prot Function:
Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis

Gene Ontology (GO) - Molecular Function for CERS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 11543633
GO:0050291 sphingosine N-acyltransferase activity IBA --
genes like me logo Genes that share ontologies with CERS2: view
genes like me logo Genes that share phenotypes with CERS2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CERS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CERS2 Gene

Localization for CERS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERS2 Gene

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for CERS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with CERS2: view

No data available for Subcellular locations from COMPARTMENTS for CERS2 Gene

Pathways for CERS2 Gene

genes like me logo Genes that share pathways with CERS2: view

Pathways by source for CERS2 Gene

Gene Ontology (GO) - Biological Process for CERS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process TAS --
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046513 ceramide biosynthetic process IBA --
genes like me logo Genes that share ontologies with CERS2: view

Compounds for CERS2 Gene

(1) Novoseek inferred chemical compound relationships for CERS2 Gene

Compound -log(P) Hits PubMed IDs
maleimide 80.3 2
genes like me logo Genes that share compounds with CERS2: view

Transcripts for CERS2 Gene

Unigene Clusters for CERS2 Gene

Ceramide synthase 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CERS2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CERS2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - -
SP8:
SP9: - -
SP10:
SP11:
SP12: -

ExUns: 12b ^ 13a · 13b · 13c ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CERS2 Gene

GeneLoc Exon Structure for
CERS2
ECgene alternative splicing isoforms for
CERS2

Expression for CERS2 Gene

mRNA expression in normal human tissues for CERS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CERS2 Gene

This gene is overexpressed in Liver (5.5).

Protein differential expression in normal tissues for CERS2 Gene

This gene is overexpressed in Liver (7.2) and Bone (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CERS2 Gene

SOURCE GeneReport for Unigene cluster for CERS2 Gene Hs.744017

mRNA Expression by UniProt/SwissProt for CERS2 Gene

Q96G23-CERS2_HUMAN
Tissue specificity: Expressed in kidney, liver, brain, heart, placenta and lung.
genes like me logo Genes that share expressions with CERS2: view

Expression partners for CERS2 Gene

In Situ Assay Products

Orthologs for CERS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CERS2 35
  • 93.33 (n)
  • 96.05 (a)
CERS2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CERS2 35
  • 92.54 (n)
  • 97.63 (a)
CERS2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cers2 35
  • 90.88 (n)
  • 92.37 (a)
Cers2 16
Cers2 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LASS2 35
  • 99.91 (n)
  • 100 (a)
LASS2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cers2 35
  • 91.14 (n)
  • 92.37 (a)
oppossum
(Monodelphis domestica)
Mammalia CERS2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CERS2 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857262 35
  • 78.72 (n)
  • 82.45 (a)
-- 36
  • 84 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia CERS2 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cers2 35
  • 70.63 (n)
  • 73.28 (a)
Str.6992 35
zebrafish
(Danio rerio)
Actinopterygii cers2a 35
  • 66.58 (n)
  • 66.49 (a)
trh3 35
cers2a 36
  • 66 (a)
OneToMany
cers2b 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta schlank 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hyl-1 36
  • 30 (a)
ManyToMany
hyl-2 36
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAC1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons LAG13 35
  • 46.54 (n)
  • 40.09 (a)
rice
(Oryza sativa)
Liliopsida Os02g0581300 35
  • 45.3 (n)
  • 35.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
Species with no ortholog for CERS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERS2 Gene

ENSEMBL:
Gene Tree for CERS2 (if available)
TreeFam:
Gene Tree for CERS2 (if available)

Paralogs for CERS2 Gene

Paralogs for CERS2 Gene

Selected SIMAP similar genes for CERS2 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with CERS2: view

Variants for CERS2 Gene

Sequence variations from dbSNP and Humsavar for CERS2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8444 -- 150,966,095(-) TACCC(C/T)GCTCC utr-variant-3-prime
rs267735 -- 150,976,020(-) TTTTT(A/T)AATTT upstream-variant-2KB
rs267736 -- 150,973,131(-) CTAGT(A/T)CATGA intron-variant
rs267737 -- 150,972,065(-) CCCTG(C/T)TTTGC intron-variant
rs267738 - 150,968,149(-) GGTAG(A/C)GCGTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CERS2 Gene

Variant ID Type Subtype PubMed ID
nsv522317 CNV Loss 19592680
nsv522840 CNV Gain 19592680

Relevant External Links for CERS2 Gene

HapMap Linkage Disequilibrium report
CERS2
Human Gene Mutation Database (HGMD)
CERS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERS2 Gene

Disorders for CERS2 Gene

(3) Novoseek inferred disease relationships for CERS2 Gene

Disease -log(P) Hits PubMed IDs
metastasis 26.6 7
cancer 11.3 3
tumors 4.65 9
genes like me logo Genes that share disorders with CERS2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for CERS2 Gene

Publications for CERS2 Gene

  1. Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PMID: 11543633) Pan H. … Gu J.-R. (Genomics 2001) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PMID: 16263699) Lewandrowski U. … Sickmann A. (Mol. Cell. Proteomics 2006) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for CERS2 Gene

Sources for CERS2 Gene

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