Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CERS2 Gene

protein-coding GIFtS: 54
GCID: GC01M150934

Ceramide Synthase 2

(Previous names: longevity assurance (LAG1, S. cerevisiae) homolog 2, LAG1...)
(Previous symbol: LASS2)

5 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Ceramide Synthase 2¹ ²		TMSG1² ³
LASS2¹ ² ³ ⁵		LAG1 Longevity Assurance Homolog 2 (S. Cerevisiae)¹
LAG1 Homolog, Ceramide Synthase 2¹ ²		L3²
Longevity Assurance (LAG1, S. Cerevisiae) Homolog 2¹ ²		LAG1 Longevity Assurance 2²
Tumor Metastasis-Suppressor Gene 1 Protein² ³		CerS2³
SP260² ³		LAG1 Longevity Assurance Homolog 2³

External Ids:	HGNC: 14076¹	Entrez Gene: 29956²	Ensembl: ENSG00000143418⁷	OMIM: 606920⁵	UniProtKB: Q96G23³

Export aliases for CERS2 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CERS2 Gene:

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or

overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a

role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have

been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for CERS2 Gene:

CERS2 (ceramide synthase 2) is a protein-coding gene. Diseases associated with CERS2 include kidney disease, and gastric cancer, and among its related super-pathways are Sphingolipid metabolism and Metabolic pathways. GO annotations related to this gene include sphingosine N-acyltransferase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CERS4.

UniProtKB/Swiss-Prot: CERS2_HUMAN, Q96G23

Function: Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis

Gene Wiki entry for CERS2 (LASS2) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NT_004487.19 NC_018912.2

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for CERS2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CERS2 promoter sequence

Search SABiosciences Chromatin IP Primers for CERS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CERS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3

CERS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CERS2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M150934: view genomic region (about GC identifiers)

Start:	150,933,059 bp from pter	End:	150,947,479 bp from pter
Size:	14,421 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CERS2_HUMAN, Q96G23 (See protein sequence)

Recommended Name: Ceramide synthase 2

Size: 380 amino acids; 44876 Da

Subunit: Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR

Subcellular location: Nucleus membrane; Multi-pass membrane protein (Potential). Endoplasmic reticulum membrane;

Multi-pass membrane protein (By similarity)

Sequence caution: Sequence=BAA91505.1; Type=Erroneous initiation;

Secondary accessions: D3DV06 Q5SZE5 Q9HD96 Q9NW79

Explore the universe of human proteins at neXtProt for CERS2: NX_Q96G23

Explore proteomics data for CERS2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q96G23

CERS2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_071358.1 NP_859530.1

ENSEMBL proteins:

ENSP00000454160 ENSP00000453297 ENSP00000357950 ENSP00000357945 ENSP00000355020

ENSP00000452810 ENSP00000393239 ENSP00000394012 ENSP00000271688

Reactome Protein details: Q96G23
Human Recombinant Protein Products for CERS2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for CERS2 OriGene Protein Over-expression Lysate for CERS2 OriGene MassSpec for CERS2 OriGene Custom Protein Services for CERS2
	GenScript Custom Purified and Recombinant Proteins Services for CERS2
	Novus Biologicals CERS2 Protein Novus Biologicals CERS2 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0016021	integral to membrane	IEA	--
GO:0031965	nuclear membrane	IDA	--

CERS2 for ontologies About GeneDecksing

CERS2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CERS2
	GenScript Custom Superior Antibodies Services for CERS2
	Novus Biologicals CERS2 Antibodies
	Abcam antibodies for CERS2
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for CERS2
	LSBio Antibodies in human, mouse, rat for CERS2

Assay Products for CERS2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CERS2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CERS2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

CERS: Homeoboxes / CERS class

4 InterPro protein domains:

IPR016439 Longevity_assurance_LAG1_LAC1

IPR001356 Homeodomain

IPR009057 Homeodomain-like

IPR006634 TLC-dom

Graphical View of Domain Structure for InterPro Entry Q96G23

ProtoNet protein and cluster: Q96G23

2 Blocks protein domains:

IPB005547 Longevity-assurance protein (LAG1)

IPB006634 TRAM

UniProtKB/Swiss-Prot: CERS2_HUMAN, Q96G23

Similarity: Contains 1 homeobox DNA-binding domain

Similarity: Contains 1 TLC (TRAM/LAG1/CLN8) domain

CERS2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CERS2_HUMAN, Q96G23

Function: Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	11543633
GO:0043565	sequence-specific DNA binding	IEA	--
GO:0050291	sphingosine N-acyltransferase activity	IEA	--

CERS2 for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cers2):

homeostasis/metabolism

integument

nervous system

tumorigenesis

CERS2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for CERS2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CERS2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CERS2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CERS2

miRNA Products:		miRTarBase miRNAs that target CERS2: hsa-mir-1 (MIRT002754), hsa-mir-124 (MIRT002726)

		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CERS2
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate CERS2 (see all 39):
		hsa-miR-4307 hsa-miR-642a hsa-let-7d hsa-miR-650 hsa-let-7g hsa-miR-9 hsa-miR-124 hsa-miR-149

		SwitchGear 3'UTR luciferase reporter plasmid: CERS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for CERS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CERS2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CERS2
			Sirion Biotech Customized adenovirus for overexpression of CERS2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for CERS2 (see all 14) OriGene ORF clones in mouse, rat for CERS2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for CERS2
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS2
		Sirion Biotech Customized lentivirus for stable overexpression of CERS2 Customized lentivirus expression plasmids for stable overexpression of CERS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CERS2
		Search LifeMap BioReagents cell lines for CERS2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CERS2 About

See pathways by source

SuperPath

Contained pathways About

Sphingolipid metabolism

	Sphingolipid metabolism	0.63			Sphingolipid de novo biosynthesis	0.47
	Sphingolipid metabolism	0.63			Sphingolipid Metabolism	0.42

Metabolism

	Metabolism	0.40			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.40

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for CERS2

Sphingolipid Metabolism

4 Reactome Pathways for CERS2

	Sphingolipid metabolism
	Metabolism
	Metabolism of lipids and lipoproteins
	Sphingolipid de novo biosynthesis

2 Kegg Pathways (Kegg details for CERS2):

	Sphingolipid metabolism
	Metabolic pathways

CERS2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CERS2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/68 Interacting proteins for CERS2 (Q96G23^{1, 3} ENSP00000271688⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 68)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ASGR1	P07306¹^,³, ENSP00000269299⁴	EBI-1057080,EBI-1172335 I2D: score=3 STRING: ENSP00000269299
HSP90AA1	P07900¹^,³	EBI-1057080,EBI-296047 I2D: score=1
ASGR2	P07307¹^,³, ENSP00000347140⁴	EBI-1057080,EBI-1172636 I2D: score=3 STRING: ENSP00000347140
ATP6V0C	P27449¹^,³, ENSP00000329757⁴	EBI-1057080,EBI-721179 I2D: score=3 STRING: ENSP00000329757
SLC22A1	O15245¹^,³, ENSP00000355930⁴	EBI-1057080,EBI-1172714 I2D: score=3 STRING: ENSP00000355930

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006665	sphingolipid metabolic process	TAS	--
GO:0030148	sphingolipid biosynthetic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--
GO:0046513	ceramide biosynthetic process	IEA	--

CERS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CERS2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CERS2

1 Novoseek inferred chemical compound relationship for CERS2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
maleimide	80.3	2	15796876 (1), 15672611 (1)

Search CenterWatch for drugs/clinical trials and news about CERS2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CERS2 gene (3 alternative transcripts):

NM_022075.4 NM_181746.3 NM_013384.3

Unigene Cluster for CERS2:

Ceramide synthase 2

Hs.744017 [show with all ESTs]

Unigene Representative Sequence: NM_181746

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000482825 ENST00000561294 ENST00000560793 ENST00000345896 ENST00000368954(uc001evz.3 uc009wmh.3)

ENST00000460664 ENST00000368949 ENST00000361419 ENST00000559660 ENST00000558062

ENST00000559020 ENST00000421609 ENST00000457392 ENST00000271688(uc001evy.3)

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CERS2
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate CERS2 (see all 39):
		hsa-miR-4307 hsa-miR-642a hsa-let-7d hsa-miR-650 hsa-let-7g hsa-miR-9 hsa-miR-124 hsa-miR-149

		SwitchGear 3'UTR luciferase reporter plasmid: CERS2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for CERS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CERS2

Clone Products:		OriGene clones in human, mouse for CERS2 (see all 14) OriGene ORF clones in mouse, rat for CERS2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for CERS2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS2
		Sirion Biotech Customized lentivirus for stable overexpression of CERS2 Customized lentivirus expression plasmids for stable overexpression of CERS2

Primer Products:		OriGene qPCR primer pairs and template standards for CERS2 OriGene qSTAR qPCR primer pairs in human, mouse for CERS2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CERS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CERS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CERS2

Additional mRNA sequence:

AF177338.2 AF189062.4 AK001105.1 AK290989.1 AY091458.1 BC001357.2 BC010032.2

24 DOTS entries:

DT.95266941 DT.91758853 DT.100835331 DT.97860965 DT.100835330 DT.95125678 DT.121452948 DT.121453027

DT.95266953 DT.121453035 DT.121452946 DT.91758855 DT.100835334 DT.100835339 DT.121452942 DT.121453018

DT.100060720 DT.100708569 DT.100792734 DT.100792739 DT.313478 DT.95093003 DT.95257627 DT.97859023

24/480 AceView cDNA sequences (see all 480):

BQ440246 CF132147 BE162717 BM021887 AL537627 BU194966 BQ215160 W39754

BM802619 AA345236 CD675166 BQ225616 CB156094 T34856 BQ673270 BQ233443

BM907435 BE272613 CA392778 BU180987 AI889883 W76578 AK001105 BM272751

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for CERS2 (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8	^	9a	·	9b	·	9c	·	9d	^	10a	·	10b	^	11a	·	11b	·	11c	^	12a	·
SP1:							-		-		-		-		-																		-						-						-
SP2:							-		-		-		-		-		-																-						-						-
SP3:													-		-																		-						-						-
SP4:							-		-		-		-																				-						-
SP5:											-		-		-																		-

ExUns:	12b	^	13a	·	13b	·	13c	^	14	^	15
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CERS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CERS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCAATAAGTG

About this image

See CERS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CERS2

SOURCE GeneReport for Unigene cluster: Hs.744017

UniProtKB/Swiss-Prot: CERS2_HUMAN, Q96G23

Tissue specificity: Expressed in kidney, liver, brain, heart, placenta and lung

SABiosciences Custom PCR Arrays for CERS2

Primer Products:		OriGene qPCR primer pairs and template standards for CERS2 OriGene qSTAR qPCR primer pairs in human, mouse for CERS2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CERS2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CERS2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CERS2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERS2 gene from 10/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cers2⁵ Lass2¹	LAG1 homolog, ceramide synthase 2^{1, 5}	90.88(n)¹ 92.37(a)¹		3 (40.74 cM)⁵ 76893¹ NM_029789.1¹ NP_084065.1¹ 95314792⁵
chicken (Gallus gallus)	Aves	LOC100857262¹	ceramide synthase 2-like	80.05(n) 84.57(a)		100857262 XM_003642682.1 XP_003642730.1
lizard (Anolis carolinensis)	Reptilia	CERS2⁶	Uncharacterized protein	78(a)	1 ↔ 1	GL343893.1(124535-141147)
African clawed frog (Xenopus laevis)	Amphibia	BC042311.1²	--	69.3(n)		BC042311.1
zebrafish (Danio rerio)	Actinopterygii	trh3²	trh3 protein	75.95(n)		259251 BC045284.1
fruit fly (Drosophila melanogaster)	Insecta	schlank⁶	schlank	36(a)	1 → many	X(6151701-6161260)
worm (Caenorhabditis elegans)	Secernentea	hyl-1⁶ hyl-2⁶	Protein HYL-2	29(a) 28(a)	many ↔ many many ↔ many	IV(8540554-8544379) X(4697246-4699461)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	LAC1(YKL008C)⁴	Ceramide synthase component, involved in synthesis more	--		11(428551-427295) 853861 NP_012917.1
thale cress (Arabidopsis thaliana)	eudicotyledons	LAG13¹	LAG1 longevity assurance homolog 3	46.64(n) 39.91(a)		837919 NM_001035960.1 NP_001031037.1
rice (Oryza sativa)	Liliopsida	Os02g0581300¹	hypothetical protein	46.06(n) 36.36(a)		4329785 NM_001053779.1 NP_001047244.1

ENSEMBL Gene Tree for CERS2 (if available)
TreeFam Gene Tree for CERS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CERS2 gene

CERS4² CERS1² CERS6² CERS5² CERS3²

5 SIMAP similar genes for CERS2 using alignment to 9 protein entries: CERS2_HUMAN (see all proteins):

CERS4 CERS3 CERS6 CERS5 LASS5

CERS2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs8544^1,2	C,F,A,H	--	150937771(-)	`tttttT/Aaaaat`	2	--	ut3¹		10		MN NA WA EA	560
rs76369183^1,2	F	--	150937813(+)	`TGGTCC/TCTCTG`	2	--	ut3¹		1		WA	118
rs9436017^1,2	C,H	--	150937818(+)	`CCTCTG/ACTGAA`	2	--	ut3¹ ese³		4		NS EA	420
rs3835665^1,2	C	--	150937965(-)	`CTCCTCCT/-TTCTC`	2	--	cds¹		1		NA	2
rs111894380^1,2	C	--	150937967(+)	`GAAAGA/C/GAGGAG`	4	--	ut3¹		1		CSA	1
rs200405678^1,2		--	150937972(+)	`GAGGA-/GGCAGTCA`	2	--	cds¹		0	--	--	--	--
rs189098464^1,2	C	--	150937980(+)	`AGTCAG/TATCTT`	2	--	ut3¹		0	--	--	--	--
rs114561381^1,2	C,F	--	150937990(+)	`TAGACC/ATGTCG`	2	--	ut3¹		1		WA	118
rs192415603^1,2		--	150938003(+)	`ACAGGG/TACAGC`	2	--	ut3¹		0	--	--	--	--
rs146127085^1,2	C	--	150938023(+)	`TAGCAC/TTAAGA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CERS2 (150933059 - 150947479 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for CERS2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv522317	CNV	Loss	19592680
nsv522840	CNV	Gain	19592680

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CERS2

DNA2.0 Custom Variant and Variant Library Synthesis for CERS2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 606920 OMIM disorders: --

5 diseases for CERS2: About MalaCards

kidney disease gastric cancer prostate cancer breast cancer

prostatitis

CERS2 for disorders About GeneDecksing

3 Novoseek inferred disease relationships for CERS2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
metastasis	26.6	10	18759044 (3), 15672611 (3), 15796876 (1)
cancer	11.3	5	15672611 (2), 15796876 (1)
tumors	4.65	14	15796876 (3), 18759044 (3), 15672611 (3)

Export disorders for CERS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CERS2 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with CERS2)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PubMed id 11543633)^{1, 2, 3, 9} Pan H....Gu J.-R. (2001)
Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)^{1, 2} Lewandrowski U.... Sickmann A. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A novel tumor metastasis suppressor gene LASS2/TMSG1 i nteracts with vacuolar ATPase through its homeodomain. (PubMed id 22991218)¹ Yu W....Pei F. (2013)
LASS2 enhances chemosensitivity of breast cancer by co unteracting acidic tumor microenvironment through inhibiting activity of V-ATPas e proton pump. (PubMed id 22580606)¹ Fan S....Qin W. (2013)
Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment. (PubMed id 23585552)¹ Kirin M....Mitry D. (2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Silencing of a novel tumor metastasis suppressor gene LASS2/TMSG1 promotes invasion of prostate cancer cell in vitro through increase of vacuolar ATPase activity. (PubMed id 22573553)¹ Xu X....Pei F. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 29956	HGNC: 14076	AceView: LASS2	Ensembl:ENSG00000143418	euGenes: HUgn29956
ECgene: CERS2	Kegg: 29956	H-InvDB: CERS2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CERS2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CERS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CERS2 gene:
Search GeneIP for patents involving CERS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Protease Activity Assays and Reagents		Browse Recombinant/Natural Proteins
	Browse Stem Cell Products		Browse Tocris Biochemicals & Compounds
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for CERS2
	OriGene qPCR primer pairs and template standards for CERS2		OriGene Protein Over-expression Lysate for CERS2
	OriGene MassSpec something-or-other for CERS2		OriGene clones in human, mouse for CERS2
	OriGene qSTAR qPCR primer pairs in human, mouse for CERS2		OriGene Purified Protein for CERS2
	OriGene ORF clones in mouse, rat for CERS2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CERS2		OriGene Custom Protein Services for CERS2

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CERS2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CERS2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CERS2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CERS2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CERS2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CERS2

	GenScript Custom Purified and Recombinant Proteins Services for CERS2		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CERS2
	GenScript Custom Assay Services for CERS2		GenScript Custom Superior Antibodies Services for CERS2
	GenScript Custom overexpressing Cell Line Services for CERS2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Search Regulatory tfbs for CERS2
	Search Chromatin IP Primers for CERS2
	RT² qPCR Primer Assay in human, mouse, rat CERS2
	Search GNC Networks for CERS2
	SABiosciences Custom PCR Arrays for CERS2

Search Tocris compounds for CERS2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CERS2 antibodies
	CERS2 proteins
	CERS2 lysates

	Antibodies for CERS2
	See all of Abcam's Antibodies, Kits and Proteins for CERS2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Search LifeMap BioReagents cell lines for CERS2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS2

	SwitchGear 3'UTR luciferase reporter plasmids for CERS2
	SwitchGear Promoter luciferase reporter plasmids for CERS2

ThermoFisher Antibodies for CERS2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS2

	inGenious Targeting Laboratory - Custom generated mouse model solutions for CERS2
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CERS2

Customized:

	lentivirus for stable overexpression of CERS2
	lentivirus expression plasmids for stable overexpression of CERS2
	adenovirus for overexpression of CERS2

LSBio Antibodies in human, mouse, rat for CERS2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CERS2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CERS2 Gene

Ceramide Synthase 2

Aliases
for CERS2 gene

Summaries
for CERS2 gene

Genomic Views
for CERS2 gene

Proteins
for CERS2 gene

Protein Domains /
Families
for CERS2 gene

Function
for CERS2 gene

Pathways & Interactions
for CERS2 gene

Drugs & Compounds
for CERS2 gene

Transcripts
for CERS2 gene

Expression
for CERS2 gene

Orthologs
for CERS2 gene

Paralogs
for CERS2 gene

Genomic Variants
for CERS2 gene

Disorders / Diseases
for CERS2 gene

Publications
for CERS2 gene

External Searches for CERS2 gene

Genome Databases showing CERS2 gene

Other Databases showing CERS2 gene

Specialized Databases showing CERS2 gene

Intellectual Property
for CERS2 gene

Products
for CERS2 gene

View Random Gene

Advanced Search

Export list of displayed genes

CERS2 Gene

Ceramide Synthase 2

Aliasesfor CERS2 gene

Summariesfor CERS2 gene

Genomic Viewsfor CERS2 gene

Proteinsfor CERS2 gene

Protein Domains /Familiesfor CERS2 gene

Functionfor CERS2 gene

Pathways & Interactionsfor CERS2 gene

Drugs & Compoundsfor CERS2 gene

Transcriptsfor CERS2 gene

Expression for CERS2 gene

Orthologsfor CERS2 gene

Paralogsfor CERS2 gene

Genomic Variantsfor CERS2 gene

Disorders / Diseasesfor CERS2 gene

Publicationsfor CERS2 gene

External Searches for CERS2 gene

Genome Databases showing CERS2 gene

Other Databases showing CERS2 gene

Specialized Databases showing CERS2 gene

Intellectual Propertyfor CERS2 gene

Productsfor CERS2 gene

View Random Gene

Aliases
for CERS2 gene

Summaries
for CERS2 gene

Genomic Views
for CERS2 gene

Proteins
for CERS2 gene

Protein Domains /
Families
for CERS2 gene

Function
for CERS2 gene

Pathways & Interactions
for CERS2 gene

Drugs & Compounds
for CERS2 gene

Transcripts
for CERS2 gene

Expression
for CERS2 gene

Orthologs
for CERS2 gene

Paralogs
for CERS2 gene

Genomic Variants
for CERS2 gene

Disorders / Diseases
for CERS2 gene

Publications
for CERS2 gene

Intellectual Property
for CERS2 gene

Products
for CERS2 gene