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Aliases for CERS2 Gene

Aliases for CERS2 Gene

  • Ceramide Synthase 2 2 3 5
  • Longevity Assurance (LAG1, S. Cerevisiae) Homolog 2 2 3
  • Tumor Metastasis-Suppressor Gene 1 Protein 3 4
  • LAG1 Homolog, Ceramide Synthase 2 2 3
  • LASS2 3 4
  • SP260 3 4
  • TMSG1 3 4
  • LAG1 Longevity Assurance Homolog 2 (S. Cerevisiae) 2
  • LAG1 Longevity Assurance Homolog 2 4
  • LAG1 Longevity Assurance 2 3
  • CerS2 4
  • L3 3

External Ids for CERS2 Gene

Previous HGNC Symbols for CERS2 Gene

  • LASS2

Summaries for CERS2 Gene

Entrez Gene Summary for CERS2 Gene

  • This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for CERS2 Gene

CERS2 (Ceramide Synthase 2) is a Protein Coding gene. Among its related pathways are Sphingolipid signaling pathway and Metabolism. GO annotations related to this gene include sphingosine N-acyltransferase activity. An important paralog of this gene is CERS5.

UniProtKB/Swiss-Prot for CERS2 Gene

  • Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.

Gene Wiki entry for CERS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERS2 Gene

Genomics for CERS2 Gene

Regulatory Elements for CERS2 Gene

Enhancers for CERS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CERS2 on UCSC Golden Path with GeneCards custom track

Promoters for CERS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CERS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CERS2 Gene

150,960,583 bp from pter
150,975,004 bp from pter
14,422 bases
Minus strand

Genomic View for CERS2 Gene

Genes around CERS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERS2 Gene

Proteins for CERS2 Gene

  • Protein details for CERS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ceramide synthase 2
    Protein Accession:
    Secondary Accessions:
    • D3DV06
    • Q5SZE5
    • Q9HD96
    • Q9NW79

    Protein attributes for CERS2 Gene

    380 amino acids
    Molecular mass:
    44876 Da
    Quaternary structure:
    • Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR.
    • Sequence=BAA91505.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CERS2 Gene

Proteomics data for CERS2 Gene at MOPED

Post-translational modifications for CERS2 Gene

  • Ubiquitination at Lys 93 and Lys 96
  • Glycosylation at Asn 19
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CERS2 Gene

Domains & Families for CERS2 Gene

Gene Families for CERS2 Gene

Suggested Antigen Peptide Sequences for CERS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 homeobox DNA-binding domain.
  • Contains 1 TLC (TRAM/LAG1/CLN8) domain.
genes like me logo Genes that share domains with CERS2: view

Function for CERS2 Gene

Molecular function for CERS2 Gene

UniProtKB/Swiss-Prot Function:
Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.
genes like me logo Genes that share phenotypes with CERS2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CERS2 Gene

Localization for CERS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERS2 Gene

Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for CERS2 Gene COMPARTMENTS Subcellular localization image for CERS2 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
plasma membrane 3
golgi apparatus 2
vacuole 2
extracellular 1
lysosome 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CERS2 Gene

Pathways & Interactions for CERS2 Gene

genes like me logo Genes that share pathways with CERS2: view

Pathways by source for CERS2 Gene

Gene Ontology (GO) - Biological Process for CERS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1905045 negative regulation of Schwann cell proliferation involved in axon regeneration ISS --
genes like me logo Genes that share ontologies with CERS2: view

No data available for SIGNOR curated interactions for CERS2 Gene

Drugs & Compounds for CERS2 Gene

(3) Drugs for CERS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sphingosine Experimental Pharma 0
sphinganine Pharma 0
Coenzyme A Nutra 0

(1) Additional Compounds for CERS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CERS2: view

Transcripts for CERS2 Gene

Unigene Clusters for CERS2 Gene

Ceramide synthase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CERS2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - -
SP9: - -
SP12: -

ExUns: 12b ^ 13a · 13b · 13c ^ 14 ^ 15
SP8: - -

Relevant External Links for CERS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CERS2 Gene

mRNA expression in normal human tissues for CERS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CERS2 Gene

This gene is overexpressed in Liver (x5.5).

Protein differential expression in normal tissues from HIPED for CERS2 Gene

This gene is overexpressed in Liver (7.2) and Bone (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CERS2 Gene

SOURCE GeneReport for Unigene cluster for CERS2 Gene Hs.744017

mRNA Expression by UniProt/SwissProt for CERS2 Gene

Tissue specificity: Expressed in kidney, liver, brain, heart, placenta and lung.
genes like me logo Genes that share expression patterns with CERS2: view

Protein tissue co-expression partners for CERS2 Gene

Primer Products

Orthologs for CERS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CERS2 35
  • 93.33 (n)
  • 96.05 (a)
CERS2 36
  • 96 (a)
(Canis familiaris)
Mammalia CERS2 35
  • 92.54 (n)
  • 97.63 (a)
CERS2 36
  • 98 (a)
(Mus musculus)
Mammalia Cers2 35
  • 90.88 (n)
  • 92.37 (a)
Cers2 16
Cers2 36
  • 92 (a)
(Pan troglodytes)
Mammalia LASS2 35
  • 99.91 (n)
  • 100 (a)
LASS2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Cers2 35
  • 91.14 (n)
  • 92.37 (a)
(Monodelphis domestica)
Mammalia CERS2 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia CERS2 36
  • 93 (a)
(Gallus gallus)
Aves LOC100857262 35
  • 78.72 (n)
  • 82.45 (a)
-- 36
  • 84 (a)
-- 36
  • 84 (a)
(Anolis carolinensis)
Reptilia CERS2 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cers2 35
  • 70.63 (n)
  • 73.28 (a)
Str.6992 35
(Danio rerio)
Actinopterygii cers2a 35
  • 66.58 (n)
  • 66.49 (a)
trh3 35
cers2a 36
  • 66 (a)
cers2b 36
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta schlank 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea hyl-1 36
  • 30 (a)
hyl-2 36
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAC1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons LAG13 35
  • 46.54 (n)
  • 40.09 (a)
(Oryza sativa)
Liliopsida Os02g0581300 35
  • 45.3 (n)
  • 35.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
-- 36
  • 42 (a)
-- 36
  • 37 (a)
-- 36
  • 33 (a)
Species with no ortholog for CERS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERS2 Gene

Gene Tree for CERS2 (if available)
Gene Tree for CERS2 (if available)

Paralogs for CERS2 Gene

Paralogs for CERS2 Gene

genes like me logo Genes that share paralogs with CERS2: view

Variants for CERS2 Gene

Sequence variations from dbSNP and Humsavar for CERS2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs267738 - 150,968,149(-) GGTAG(A/C/T)GCGTT reference, missense
rs8444 -- 150,966,095(-) TACCC(C/T)GCTCC utr-variant-3-prime
rs267735 -- 150,976,020(-) TTTTT(A/T)AATTT upstream-variant-2KB
rs267736 -- 150,973,131(-) CTAGT(A/T)CATGA intron-variant, upstream-variant-2KB
rs267737 -- 150,972,065(-) CCCTG(C/T)TTTGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CERS2 Gene

Variant ID Type Subtype PubMed ID
nsv522317 CNV Loss 19592680
nsv522840 CNV Gain 19592680

Variation tolerance for CERS2 Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CERS2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERS2 Gene

Disorders for CERS2 Gene

Relevant External Links for CERS2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CERS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CERS2 Gene

Publications for CERS2 Gene

  1. Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PMID: 11543633) Pan H. … Gu J.-R. (Genomics 2001) 2 3 4 23 67
  2. CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer. (PMID: 25213553) Fan S.H. … Cheng W. (J. Cell. Biochem. 2015) 3
  3. LASS2/TMSG1 inhibits growth and invasion of breast cancer cell in vitro through regulation of vacuolar ATPase activity. (PMID: 25501280) Mei F. … Pei F. (Tumour Biol. 2015) 3
  4. Overexpression of a Novel Tumor Metastasis Suppressor Gene TMSG1/LASS2 Induces Apoptosis via a Caspase-dependent Mitochondrial Pathway. (PMID: 25735224) Su J. … Zheng J. (J. Cell. Biochem. 2015) 3
  5. Silencing of TMSG1 enhances metastasis capacity by targeting V-ATPase in breast cancer. (PMID: 25973015) Zi Y. … Xie M. (Int J Clin Exp Pathol 2015) 3

Products for CERS2 Gene

Sources for CERS2 Gene