CERS2 Gene

Aliases
for CERS2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Summaries
for CERS2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for CERS2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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SwitchGear Promoter luciferase reporter plasmid: CERS2 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CERS2

CERS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M150934:  view genomic region     (about GC identifiers)

Proteins
for CERS2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for CERS2: NX_Q96G23

Explore proteomics data for CERS2 at MOPED

Post-translational modifications: 

CERS2 Human Recombinant Protein Products:

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	Novus Biologicals CERS2 Protein Novus Biologicals CERS2 Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for CERS2
	Search GeneTex for Proteins for CERS2
	antibodies-online proteins for CERS2
	antibodies-online peptides for CERS2

CERS2 Antibody Products:

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	antibodies-online antibodies for CERS2 (36 products)

CERS2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for CERS2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for CERS2
	antibodies-online kits for CERS2 (3 products)

Domains /
Families
for CERS2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q96G23

Find genes that share domains with CERS2           About GenesLikeMe

Function
for CERS2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 5 molecular function terms:    About this table

(inferred from 1 allele) (MGI details for Cers2)

genOway: Develop your customized and physiologically relevant rodent model for CERS2

miRNA Products:		miRTarBase miRNAs that target CERS2: hsa-mir-101-3p (MIRT027344), hsa-mir-124-3p (MIRT002726), hsa-mir-1 (MIRT002754), hsa-mir-625-5p (MIRT039594), hsa-mir-221-3p (MIRT006917), hsa-mir-20a-5p (MIRT050621), hsa-mir-9-5p (MIRT021462), hsa-mir-222-3p (MIRT006918), hsa-mir-133a-3p (MIRT021707), hsa-mir-93-5p (MIRT028158)
		Block miRNA regulation of human, mouse, rat CERS2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate CERS2 (see all 39):
		hsa-miR-4307 hsa-miR-642a hsa-let-7d hsa-miR-650 hsa-let-7g hsa-miR-9 hsa-miR-124 hsa-miR-149
		SwitchGear 3'UTR luciferase reporter plasmid: CERS2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CERS2
		Predesigned siRNA for gene silencing in human, mouse, rat CERS2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for CERS2

Clone Products:		OriGene clones in human, mouse for CERS2 (see all 13) OriGene ORF clones in mouse, rat for CERS2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for CERS2
		Sino Biological Human cDNA Clone for CERS2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CERS2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CERS2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CERS2
		Browse ESI BIO Cell Lines and PureStem Progenitors for CERS2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS2

Localization
for CERS2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for CERS2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for CERS2 About     See pathways by source

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	SuperPath	Contained pathways About
1	Sphingolipid metabolism	Sphingolipid metabolism 0.61 Sphingolipid de novo biosynthesis 0.46 Sphingolipid metabolism 0.61 Sphingolipid Metabolism 0.42
2	Metabolism	Metabolism 0.38 Metabolism of lipids and lipoproteins 0.37 Metabolic pathways 0.38

1 BioSystems Pathway for CERS2

Sphingolipid Metabolism

1 Reactome Pathway for CERS2

Sphingolipid de novo biosynthesis

2 Kegg Pathways  (Kegg details for CERS2)

	Sphingolipid metabolism
	Metabolic pathways

Gene Ontology (GO): 5 biological process terms:    About this table

Drugs & Compounds
for CERS2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for CERS2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for CERS2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CERS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCAATAAGTG

About this image

Brain (Nervous System)
Cerebral Cortex
Bone (Muscoskeletal System)
Bone Marrow
Colon (Gastrointestinal Tract)
Uterus (Reproductive System)
Thyroid (Endocrine System)

Primer Products:		OriGene qPCR primer pairs and template standards for CERS2 OriGene qSTAR qPCR primer pairs in human, mouse for CERS2
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CERS2
		QuantiTect SYBR Green Assays in human, mouse, rat CERS2
		QuantiFast Probe-based Assays in human, mouse, rat CERS2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERS2

Orthologs
for CERS2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for CERS2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for CERS2 gene

CERS4²  CERS1²  CERS6²  CERS5²  CERS3²  

5 SIMAP similar genes for CERS2 using alignment to 9 protein entries:     CERS2_HUMAN (see all proteins):

CERS3    CERS4    CERS6    CERS5    LASS5

Find genes that share paralogs with CERS2           About GenesLikeMe

Genomic Variants
for CERS2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CERS2 (see all 248)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs85441,2	C,F,A,H	--	150937771(-)	tttttT/Aaaaat	2	--	ut31		10		MN NA WA EA	560
rs763691831,2	F	--	150937813(+)	TGGTCC/TCTCTG	2	--	ut31		1		WA	118
rs94360171,2	C,H	--	150937818(+)	CCTCTG/ACTGAA	2	--	ut31 ese3		4		NS EA	420
rs38356651,2	C	--	150937965(-)	CTCCTCCT/-TTCTC	2	--	cds1		1		NA	2
rs1118943801,2	C	--	150937967(+)	GAAAGA/C/GAGGAG	4	--	ut31		1		CSA	1
rs2004056781,2		--	150937972(+)	GAGGA-/GGCAGTCA	2	--	cds1		0	--	--	--	--
rs1890984641,2	C	--	150937980(+)	AGTCAG/TATCTT	2	--	ut31		0	--	--	--	--
rs1145613811,2	C,F	--	150937990(+)	TAGACC/ATGTCG	2	--	ut31		1		WA	118
rs1924156031,2		--	150938003(+)	ACAGGG/TACAGC	2	--	ut31		0	--	--	--	--
rs1461270851,2	C	--	150938023(+)	TAGCAC/TTAAGA	2	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for CERS2 (150933059 - 150947479 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for CERS2:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv522317	CNV	Loss	19592680
nsv522840	CNV	Gain	19592680

Human Gene Mutation Database (HGMD): CERS2

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing CERS2

DNA2.0 Custom Variant and Variant Library Synthesis for CERS2

Disorders / Diseases
for CERS2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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3 Novoseek inferred disease relationships for CERS2 gene    About this table

Publications
for CERS2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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1. Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PubMed id 11543633)^{1, 2, 3, 9} Pan H....Gu J.-R. (Genomics 2001)
2. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. (PubMed id 20937905)^{1, 2} Ohno Y.... Kihara A. (Proc. Natl. Acad. Sci. U.S.A. 2010)
3. Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PubMed id 16263699)^{1, 2} Lewandrowski U.... Sickmann A. (Mol. Cell. Proteomics 2006)
4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
7. The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS. (PubMed id 23538298)¹ Hartmann D....GrAPsch S. (amp 2013)
8. A novel tumor metastasis suppressor gene LASS2/TMSG1 interacts with vacuolar ATPase through its homeodomain. (PubMed id 22991218)¹ Yu W....Pei F. (J. Cell. Biochem. 2013)
9. LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump. (PubMed id 22580606)¹ Fan S....Qin W. (Oncogene 2013)
10. Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models. (PubMed id 23690971)¹ Petrache I....Futerman A.H. (PLoS ONE 2013)

External Searches for CERS2 gene

Genome Databases showing CERS2 gene

Other Databases showing CERS2 gene

Specialized Databases showing CERS2 gene

Products
for CERS2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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