Aliases for CERS2 Gene
Aliases for CERS2 Gene
External Ids for CERS2 Gene
- HGNC: 14076
- Entrez Gene: 29956
- Ensembl: ENSG00000143418
- OMIM: 606920
- UniProtKB: Q96G23
Previous HGNC Symbols for CERS2 Gene
- LASS2
Summaries for CERS2 Gene
-
This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for CERS2 Gene
CERS2 (Ceramide Synthase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include sphingosine N-acyltransferase activity. An important paralog of this gene is CERS3.
UniProtKB/Swiss-Prot for CERS2 Gene
-
Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.
Additional gene information for CERS2 Gene
- Monarch Initiative
- Search for CERS2 at DataMed
- Search for CERS2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERS2 Gene
Genomics for CERS2 Gene
GeneHancer (GH) Regulatory Elements for CERS2 Gene
Promoters and enhancers for CERS2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CERS2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CERS2 Gene
Genomic Locations for CERS2 Gene
- chr1:150,960,583-150,975,004
- (GRCh38/hg38)
- Size:
- 14,422 bases
- Orientation:
- Minus strand
- chr1:150,933,059-150,947,479
- (GRCh37/hg19)
Genomic View for CERS2 Gene
Genes around CERS2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
CERS2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CERS2 Gene
Proteins for CERS2 Gene
-
Protein details for CERS2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96G23-CERS2_HUMAN
- Recommended name:
- Ceramide synthase 2
- Protein Accession:
- Q96G23
- D3DV06
- Q5SZE5
- Q9HD96
- Q9NW79
Protein attributes for CERS2 Gene
- Size:
- 380 amino acids
- Molecular mass:
- 44876 Da
- Quaternary structure:
-
- Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Interacts with ELOV1, HSD17B12 and TECR.
- SequenceCaution:
-
- Sequence=BAA91505.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for CERS2 Gene
Post-translational modifications for CERS2 Gene
Other Protein References for CERS2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for CERS2
- Novus Biologicals Antibodies for CERS2
-
Abcam antibodies for CERS2
-
Cloud-Clone Corp. Antibodies for CERS2
- Invitrogen Antibodies for CERS2
- GeneTex CERS2 antibody for CERS2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CERS2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for CERS2
- Origene Custom Protein Services for CERS2
-
Cloud-Clone Corp. Proteins for CERS2
- antibodies-online: Search results for 5 available CERS2 Proteins ranked by validation data
- Compare Top CERS2 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CERS2
-
Abcam proteins for CERS2
Assay Products
-
Cloud-Clone Corp. Assay Kits for CERS2
- antibodies-online: Search results for 5 available CERS2 Elisa Kits ranked by validation data
- Compare Top CERS2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CERS2 Gene
Domains & Families for CERS2 Gene
Gene Families for CERS2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for CERS2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CERS2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for CERS2 Gene
Function for CERS2 Gene
Molecular function for CERS2 Gene
- UniProtKB/Swiss-Prot Function:
- Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis.
Phenotypes From GWAS Catalog for CERS2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 11543633 |
| GO:0050291 | sphingosine N-acyltransferase activity | IEA,TAS | -- |
Phenotypes for CERS2 Gene
- MGI mutant phenotypes for CERS2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for CERS2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CERS2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CERS2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CERS2 gene
- Search ViGene Biosciences for CERS2
CRISPR Products
-
OriGene CRISPR knockouts for CERS2
- genomics-online: gRNA clones - Search results for available CERS2 gene related products
- Applied Biological Materials CRISPR for CERS2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CERS2
- GenScript: Design CRISPR guide RNA sequences for CERS2
miRNA for CERS2 Gene
- miRTarBase miRNAs that target CERS2
-
- hsa-mir-124-3p (MIRT002726)
- hsa-mir-1-3p (MIRT002754)
- hsa-mir-221-3p (MIRT006917)
- hsa-mir-222-3p (MIRT006918)
- hsa-mir-9-5p (MIRT021462)
- hsa-mir-133a-3p (MIRT021707)
- hsa-mir-101-3p (MIRT027344)
- hsa-mir-93-5p (MIRT028158)
- hsa-mir-625-5p (MIRT039594)
- hsa-mir-20a-5p (MIRT050621)
- hsa-mir-1257 (MIRT479324)
- hsa-mir-219a-2-3p (MIRT479325)
- hsa-mir-219b-3p (MIRT479326)
- hsa-mir-4330 (MIRT479327)
- hsa-mir-5195-5p (MIRT479328)
- hsa-mir-5571-5p (MIRT479329)
- hsa-mir-8066 (MIRT479330)
- hsa-mir-651-3p (MIRT479331)
- hsa-mir-613 (MIRT479332)
- hsa-mir-206 (MIRT479333)
- hsa-mir-659-3p (MIRT507733)
- hsa-mir-6736-5p (MIRT507734)
- hsa-mir-4701-3p (MIRT507735)
- hsa-mir-1262 (MIRT507736)
- hsa-mir-6857-5p (MIRT507737)
- hsa-mir-4504 (MIRT507738)
- hsa-mir-299-5p (MIRT507739)
- hsa-mir-4450 (MIRT507740)
- hsa-mir-5191 (MIRT507741)
- hsa-mir-6776-5p (MIRT507742)
- hsa-mir-8089 (MIRT507743)
- hsa-mir-4700-5p (MIRT507744)
- hsa-mir-4667-5p (MIRT507745)
- hsa-mir-6852-5p (MIRT507746)
- hsa-mir-5002-5p (MIRT507747)
- hsa-mir-4478 (MIRT507748)
- hsa-mir-4419b (MIRT507749)
- hsa-mir-3929 (MIRT507750)
- hsa-mir-7851-3p (MIRT507751)
- hsa-mir-4484 (MIRT507752)
- hsa-mir-6768-3p (MIRT507753)
- hsa-mir-548an (MIRT507754)
- hsa-mir-29b-2-5p (MIRT568061)
- hsa-mir-1253 (MIRT736536)
- hsa-mir-1827 (MIRT738089)
- hsa-mir-2682-5p (MIRT739413)
- hsa-mir-3173-3p (MIRT740609)
- hsa-mir-3179 (MIRT740721)
- hsa-mir-3202 (MIRT741133)
- hsa-mir-34b-5p (MIRT741454)
- hsa-mir-3612 (MIRT741554)
- hsa-mir-3919 (MIRT742942)
- hsa-mir-4271 (MIRT743612)
- hsa-mir-449c-5p (MIRT745452)
- hsa-mir-4695-5p (MIRT747168)
- hsa-mir-4709-3p (MIRT747377)
- hsa-mir-4716-3p (MIRT747481)
- hsa-mir-4725-3p (MIRT747693)
- hsa-mir-4747-5p (MIRT748228)
- hsa-mir-5196-5p (MIRT750012)
- hsa-mir-5197-3p (MIRT750082)
- hsa-mir-6077 (MIRT751695)
- hsa-mir-650 (MIRT753002)
- hsa-mir-6780b-5p (MIRT755624)
- hsa-mir-6794-5p (MIRT756081)
- hsa-mir-6873-5p (MIRT758059)
- hsa-mir-6891-5p (MIRT758667)
- hsa-mir-765 (MIRT759547)
- hsa-mir-9500 (MIRT760876)
- hsa-mir-1288-5p (MIRT762251)
- hsa-mir-3684 (MIRT766771)
- hsa-mir-5100 (MIRT773310)
- hsa-mir-7161-3p (MIRT781667)
miRNA Products
- Search ViGene Biosciences for CERS2
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for CERS2
- Browse OriGene Inhibitory RNA Products For CERS2
- genomics-online: shRNA clones - Search results for available CERS2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CERS2 gene
Clone Products
- Sino Biological Human cDNA Clone for CERS2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CERS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CERS2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available CERS2 gene related products
- orf clones - Search results for available CERS2 gene related products
- Applied Biological Materials Clones for CERS2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CERS2
-
ViGene Biosciences adenoviral particle packaged cDNA for CERS2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CERS2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CERS2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CERS2 Gene
Localization for CERS2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CERS2 Gene
- Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| nucleus | 4 |
| plasma membrane | 3 |
| golgi apparatus | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| lysosome | 1 |
- Endoplasmic reticulum (3)
- Nuclear membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IBA | -- |
| GO:0005789 | endoplasmic reticulum membrane | TAS | -- |
| GO:0016020 | membrane | IEA,HDA | 19946888 |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for CERS2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Sphingolipid metabolism | ||
| 2 | Metabolism |
.37
|
|
| 3 | Sphingolipid signaling pathway | ||
Pathways by source for CERS2 Gene
1 BioSystems pathway for CERS2 Gene
4 Reactome pathways for CERS2 Gene
3 KEGG pathways for CERS2 Gene
Interacting Proteins for CERS2 Gene
Selected Interacting proteins:
ENSP00000271688
Q96G23-CERS2_HUMAN
for CERS2 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006629 | lipid metabolic process | IEA | -- |
| GO:0030148 | sphingolipid biosynthetic process | IEA,TAS | -- |
| GO:0046513 | ceramide biosynthetic process | IEA,IBA | -- |
| GO:0048681 | negative regulation of axon regeneration | IEA,ISS | -- |
| GO:1900148 | negative regulation of Schwann cell migration | IEA,ISS | -- |
No data available for SIGNOR curated interactions for CERS2 Gene
Transcripts for CERS2 Gene
mRNA/cDNA for CERS2 Gene
- (5) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (480) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CERS2
- genomics-online: gRNA clones - Search results for available CERS2 gene related products
- Applied Biological Materials CRISPR for CERS2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CERS2
- GenScript: Design CRISPR guide RNA sequences for CERS2
miRNA Products
- Search ViGene Biosciences for CERS2
Inhibitory RNA Products
- Origene shrna and RNAi products in human, mouse, rat for CERS2
- Browse OriGene Inhibitory RNA Products For CERS2
- genomics-online: shRNA clones - Search results for available CERS2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CERS2 gene
Clone Products
- Sino Biological Human cDNA Clone for CERS2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CERS2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CERS2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available CERS2 gene related products
- orf clones - Search results for available CERS2 gene related products
- Applied Biological Materials Clones for CERS2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - |
| ExUns: | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | |||||||||||
| SP3: | |||||||||||
| SP4: | |||||||||||
| SP5: | |||||||||||
| SP6: | |||||||||||
| SP7: | |||||||||||
| SP8: | - | - | |||||||||
| SP9: | |||||||||||
| SP10: | |||||||||||
| SP11: | |||||||||||
| SP12: |
Expression for CERS2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for CERS2 Gene
This gene is overexpressed in Liver (x5.5).
This gene is overexpressed in Liver (7.2) and Bone (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CERS2 Gene
NURSA nuclear receptor signaling pathways regulating expression of CERS2 Gene:
CERS2SOURCE GeneReport for Unigene cluster for CERS2 Gene:
Hs.744017mRNA Expression by UniProt/SwissProt for CERS2 Gene:
Q96G23-CERS2_HUMAN
Tissue specificity:
Expressed in kidney, liver, brain, heart, placenta and lung.
Evidence on tissue expression from TISSUES for CERS2 Gene
- Liver(4.7)
- Kidney(4.6)
- Skin(4.3)
- Blood(4.1)
- Nervous system(2.8)
- Adrenal gland(2.2)
- Thyroid gland(2.1)
- Intestine(2)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CERS2
-
OriGene qPCR primer pairs for CERS2
- genomics-online: primer clones - Search results for available CERS2 gene related products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CERS2 Gene
Orthologs for CERS2 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | LASS2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CERS2 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CERS2 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | CERS2 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CERS2 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Cers2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Cers2 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| LOC100859441 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | CERS2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cers2 33 |
|
||
| Str.6992 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | cers2a 33 34 |
|
||
| cers2b 34 |
|
OneToMany | |||
| trh3 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | schlank 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | hyl-1 34 |
|
ManyToMany | |
| hyl-2 34 |
|
ManyToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | LAC1 36 |
|
|
|
| thale cress (Arabidopsis thaliana) |
eudicotyledons | LAG13 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os02g0581300 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany |
- Species where no ortholog for CERS2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CERS2 Gene
(5) SIMAP similar genes for CERS2 Gene using alignment to 9 proteins:
Variants for CERS2 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000107487 | -- | 150,965,780(-) | T/C | 3_prime_UTR_variant | |
| rs1000373232 | -- | 150,967,635(-) | A/C | intron_variant | |
| rs1000405833 | -- | 150,967,297(-) | G/A | intron_variant | |
| rs1000826372 | -- | 150,976,657(-) | CTCT/CT | upstream_transcript_variant | |
| rs1000882540 | -- | 150,973,347(-) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1008496 | CNV | gain | 25217958 |
| nsv1142781 | CNV | deletion | 24896259 |
| nsv522317 | CNV | loss | 19592680 |
| nsv522840 | CNV | gain | 19592680 |
| nsv952804 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.85;
67.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CERS2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERS2 Gene
Disorders for CERS2 Gene
Additional Disease Information for CERS2
No disorders were found for CERS2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CERS2 Gene
Publications for CERS2 Gene
- Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. (PMID: 11543633) Pan H … Gu JR (Genomics 2001) 2 3 4 22 58
- ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. (PMID: 20937905) Ohno Y … Kihara A (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 58
- Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. (PMID: 16263699) Lewandrowski U … Sickmann A (Molecular & cellular proteomics : MCP 2006) 3 4 58
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for CERS2 Gene
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