Aliases for CERS1 Gene
External Ids for CERS1 Gene
Previous HGNC Symbols for CERS1 Gene
Previous GeneCards Identifiers for CERS1 Gene
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for CERS1 Gene
CERS1 (Ceramide Synthase 1) is a Protein Coding gene. Diseases associated with CERS1 include epilepsy, progressive myoclonic, 8. Among its related pathways are Metabolism and Sphingolipid metabolism. GO annotations related to this gene include cytokine activity and sphingosine N-acyltransferase activity. An important paralog of this gene is CERS5.
UniProtKB/Swiss-Prot for CERS1 Gene
May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity).