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Aliases for CERNA2 Gene

Subcategory (RNA class) for CERNA2 Gene

non-coding RNA

Quality Score for this RNA gene is

2

Aliases for CERNA2 Gene

  • Competing Endogenous LncRNA 2 For MicroRNA Let-7b 2 3
  • Human Ovarian Cancer Specific Transcript 2 2
  • Human Ovarian Cancer-Specific Transcript 2 3
  • LncRNA-HOST2 3
  • HOST2 3

External Ids for CERNA2 Gene

Summaries for CERNA2 Gene

Entrez Gene Summary for CERNA2 Gene

  • This gene produces a long non-coding transcript that functions in ovarian carcinogenesis by promoting tumor cell migration, invasion and proliferation. It binds to the microRNA let-7b (MIRLET7B), which is a potent tumor suppressor, thereby inhibiting the functions of that microRNA by modulating its availability to its targets. [provided by RefSeq, Dec 2015]

GeneCards Summary for CERNA2 Gene

CERNA2 (Competing Endogenous LncRNA 2 For MicroRNA Let-7b) is an RNA Gene, and is affiliated with the non-coding RNA class.

Additional gene information for CERNA2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERNA2 Gene

Genomics for CERNA2 Gene

Regulatory Elements for CERNA2 Gene

Enhancers for CERNA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H084171 1 ENCODE dbSUPER 0.7 -0.6 -576 2.8 HDGF PKNOX1 RB1 MAX BACH1 EBF1 POLR2A EED ATF7 IKZF2 CDHR1 LRIT2 C10orf99 CERNA2
GH10H084156 1 Ensembl ENCODE 0.4 +15.2 15161 0.8 HDAC1 CTCF PKNOX1 ETV1 JUN MAX CEBPG ZIC2 FOSL1 CTBP1 CDHR1 LRIT2 RNU1-65P ENSG00000271933 C10orf99 CERNA2
GH10H084163 0.4 dbSUPER 0.4 +8.3 8269 1.1 KLF17 CDHR1 LRIT2 LRIT1 CERNA2 ENSG00000271933
GH10H084148 0.5 ENCODE 0.3 +24.0 23999 0.1 CTCF SMC3 ZNF143 RAD21 CDHR1 ENSG00000271933 CERNA2
GH10H084159 0.2 dbSUPER 0.4 +12.9 12859 0.6 CDHR1 LRIT2 LRIT1 RNU1-65P C10orf99 CERNA2 ENSG00000271933
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CERNA2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CERNA2 Gene

Genomic Locations for CERNA2 Gene
chr10:84,167,228-84,172,188
(GRCh38/hg38)
Size:
4,961 bases
Orientation:
Minus strand

Genomic View for CERNA2 Gene

Genes around CERNA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERNA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERNA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERNA2 Gene

Proteins for CERNA2 Gene

Post-translational modifications for CERNA2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for CERNA2 Gene

Domains & Families for CERNA2 Gene

Gene Families for CERNA2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CERNA2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CERNA2 Gene

Function for CERNA2 Gene

genes like me logo Genes that share phenotypes with CERNA2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CERNA2 Gene

Localization for CERNA2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CERNA2 Gene

Pathways & Interactions for CERNA2 Gene

SuperPathways for CERNA2 Gene

No Data Available

Interacting Proteins for CERNA2 Gene

Gene Ontology (GO) - Biological Process for CERNA2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CERNA2 Gene

Drugs & Compounds for CERNA2 Gene

No Compound Related Data Available

Transcripts for CERNA2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CERNA2 Gene

No ASD Table

Relevant External Links for CERNA2 Gene

GeneLoc Exon Structure for
CERNA2
ECgene alternative splicing isoforms for
CERNA2

No data available for mRNA/cDNA for CERNA2 Gene

Expression for CERNA2 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CERNA2 Gene

Orthologs for CERNA2 Gene

No data available for Orthologs and Evolution for CERNA2 Gene

Paralogs for CERNA2 Gene

No data available for Paralogs for CERNA2 Gene

Variants for CERNA2 Gene

Sequence variations from dbSNP and Humsavar for CERNA2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000229759 -- 84,168,970(+) GCTTA(A/T)TTGCT intron-variant
rs1000322501 -- 84,169,223(+) TTGCT(C/G)TTGGT intron-variant
rs1000456378 -- 84,173,063(+) TCCTG(C/T)ACCTG upstream-variant-2KB
rs1001195109 -- 84,172,541(+) CTTCC(A/G)AAAAA upstream-variant-2KB
rs1001215036 -- 84,173,262(+) CAATA(C/T)AGGCT upstream-variant-2KB

Relevant External Links for CERNA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CERNA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for CERNA2 Gene

Disorders for CERNA2 Gene

Relevant External Links for CERNA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CERNA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CERNA2

No disorders were found for CERNA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CERNA2 Gene

Publications for CERNA2 Gene

  1. Effects of LncRNA-HOST2 on cell proliferation, migration, invasion and apoptosis of human hepatocellular carcinoma cell line SMMC-7721. (PMID: 28143959) Liu RT … Lv HT (Bioscience reports 2017) 2 3 60
  2. LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b. (PMID: 25292198) Gao Y … Hui N (Human molecular genetics 2015) 2 3 60
  3. Characterization of novel human ovarian cancer-specific transcripts (HOSTs) identified by serial analysis of gene expression. (PMID: 14562052) Rangel LB … Morin PJ (Oncogene 2003) 3 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60
  5. Effects of the Long Non-Coding RNA HOST2 On the Proliferation, Migration, Invasion and Apoptosis of Human Osteosarcoma Cells. (PMID: 28854422) Wang W … Yang CY (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3

Products for CERNA2 Gene

Sources for CERNA2 Gene

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