Aliases for CERK Gene
External Ids for CERK Gene
CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CERK Gene
CERK (Ceramide Kinase) is a Protein Coding gene. Diseases associated with CERK include retinitis pigmentosa. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include phospholipid binding and NAD+ kinase activity. An important paralog of this gene is SPHK2.
UniProtKB/Swiss-Prot for CERK Gene
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.
Ceramide kinase catalyzes the addition of a phosphate group to ceramide, generating ceramide-1-phosphate.