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Aliases for CERK Gene

Aliases for CERK Gene

  • Ceramide Kinase 2 3 5
  • Acylsphingosine Kinase 3 4
  • Lipid Kinase 4 3 4
  • HCERK 3 4
  • LK4 3 4
  • Lipid Kinase LK4 3
  • EC 2.7.1.138 4
  • DA59H18.2 3
  • DA59H18.3 3
  • KIAA1646 4

External Ids for CERK Gene

Previous GeneCards Identifiers for CERK Gene

  • GC22M043648
  • GC22M045292
  • GC22M045400
  • GC22M047080
  • GC22M030025

Summaries for CERK Gene

Entrez Gene Summary for CERK Gene

  • CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CERK Gene

CERK (Ceramide Kinase) is a Protein Coding gene. Diseases associated with CERK include Retinitis Pigmentosa. Among its related pathways are Sphingolipid metabolism and Integrated Breast Cancer Pathway. GO annotations related to this gene include magnesium ion binding and diacylglycerol kinase activity. An important paralog of this gene is SPHK2.

UniProtKB/Swiss-Prot for CERK Gene

  • Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

Tocris Summary for CERK Gene

Gene Wiki entry for CERK Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERK Gene

Genomics for CERK Gene

Regulatory Elements for CERK Gene

Enhancers for CERK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CERK on UCSC Golden Path with GeneCards custom track

Promoters for CERK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CERK on UCSC Golden Path with GeneCards custom track

Genomic Location for CERK Gene

Chromosome:
22
Start:
46,684,410 bp from pter
End:
46,738,261 bp from pter
Size:
53,852 bases
Orientation:
Minus strand

Genomic View for CERK Gene

Genes around CERK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERK Gene

Proteins for CERK Gene

  • Protein details for CERK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCT0-CERK1_HUMAN
    Recommended name:
    Ceramide kinase
    Protein Accession:
    Q8TCT0
    Secondary Accessions:
    • A0JNT4
    • A8K611
    • Q6NX59
    • Q9BYB3
    • Q9UGE5

    Protein attributes for CERK Gene

    Size:
    537 amino acids
    Molecular mass:
    59977 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CERK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CERK Gene

Proteomics data for CERK Gene at MOPED

Post-translational modifications for CERK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CERK Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CERK

No data available for DME Specific Peptides for CERK Gene

Domains & Families for CERK Gene

Protein Domains for CERK Gene

Suggested Antigen Peptide Sequences for CERK Gene

Graphical View of Domain Structure for InterPro Entry

Q8TCT0

UniProtKB/Swiss-Prot:

CERK1_HUMAN :
  • Contains 1 DAGKc domain.
Domain:
  • Contains 1 DAGKc domain.
genes like me logo Genes that share domains with CERK: view

No data available for Gene Families for CERK Gene

Function for CERK Gene

Molecular function for CERK Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.0-7.5.;
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + ceramide = ADP + ceramide 1-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sulfatide.
UniProtKB/Swiss-Prot Function:
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

Enzyme Numbers (IUBMB) for CERK Gene

Gene Ontology (GO) - Molecular Function for CERK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 10947957
genes like me logo Genes that share ontologies with CERK: view
genes like me logo Genes that share phenotypes with CERK: view

Animal Models for CERK Gene

MGI Knock Outs for CERK:

Animal Model Products

  • Taconic Biosciences Mouse Models for CERK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CERK Gene

Localization for CERK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERK Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CERK Gene COMPARTMENTS Subcellular localization image for CERK gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
cytosol 2
golgi apparatus 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CERK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with CERK: view

Pathways & Interactions for CERK Gene

genes like me logo Genes that share pathways with CERK: view

Pathways by source for CERK Gene

Gene Ontology (GO) - Biological Process for CERK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process TAS --
genes like me logo Genes that share ontologies with CERK: view

No data available for SIGNOR curated interactions for CERK Gene

Drugs & Compounds for CERK Gene

(9) Drugs for CERK Gene - From: DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
calcium Nutra 0
NVP 231 Pharma 0
Magnesium Nutra 0
Necrostatin-1 Pharma RIP1 inhibitor, RIPK1 inhibitor; inhibits necroptosis 0

(38) Additional Compounds for CERK Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Cer(d18:0/12:0)
Cer(d18:0/14:0)
Cer(d18:0/16:0)
Cer(d18:0/18:0)

(5) Tocris Compounds for CERK Gene

Compound Action Cas Number
DCA Mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor 2156-56-1
ML 202 Pyruvate kinase M2 activator 1221186-52-2
Necrostatin-1 RIPK1 inhibitor; inhibits necroptosis 4311-88-0
NH 125 CaM kinase III (eEF-2 kinase) inhibitor 278603-08-0
PD 407824 Selective inhibitor of Chk1 and Wee1 622864-54-4
genes like me logo Genes that share compounds with CERK: view

Transcripts for CERK Gene

Unigene Clusters for CERK Gene

Ceramide kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CERK Gene

No ASD Table

Relevant External Links for CERK Gene

GeneLoc Exon Structure for
CERK
ECgene alternative splicing isoforms for
CERK

Expression for CERK Gene

mRNA expression in normal human tissues for CERK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CERK Gene

This gene is overexpressed in Urine (41.5) and Lung (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CERK Gene



SOURCE GeneReport for Unigene cluster for CERK Gene Hs.200668

mRNA Expression by UniProt/SwissProt for CERK Gene

Q8TCT0-CERK1_HUMAN
Tissue specificity: High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.
genes like me logo Genes that share expression patterns with CERK: view

Protein tissue co-expression partners for CERK Gene

Primer Products

No data available for mRNA differential expression in normal tissues for CERK Gene

Orthologs for CERK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERK Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CERK 35
  • 82.94 (n)
  • 87.5 (a)
CERK 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cerk 35
  • 81.41 (n)
  • 84.88 (a)
Cerk 16
Cerk 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CERK 35
  • 99.38 (n)
  • 99.63 (a)
CERK 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cerk 35
  • 82.17 (n)
  • 85.82 (a)
cow
(Bos Taurus)
Mammalia CERK 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CERK 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CERK 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves CERK 35
  • 67.38 (n)
  • 67.19 (a)
CERK 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CERK 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487080 35
  • 62.95 (n)
  • 62.12 (a)
Str.10087 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.9645 35
zebrafish
(Danio rerio)
Actinopterygii cerk 35
  • 62.95 (n)
  • 60.36 (a)
cerk 36
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002932 35
  • 48.28 (n)
  • 42.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cerk 35
  • 47.05 (n)
  • 41.15 (a)
Cerk 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T10B11.2 35
  • 44.44 (n)
  • 35.9 (a)
T10B11.2 36
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LCB4 36
  • 13 (a)
ManyToMany
LCB5 36
  • 13 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51290 35
  • 47.12 (n)
  • 42.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToOne
Species with no ortholog for CERK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERK Gene

ENSEMBL:
Gene Tree for CERK (if available)
TreeFam:
Gene Tree for CERK (if available)

Paralogs for CERK Gene

Paralogs for CERK Gene

genes like me logo Genes that share paralogs with CERK: view

Variants for CERK Gene

Sequence variations from dbSNP and Humsavar for CERK Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs16995615 - 46,707,987(+) GACGA(A/C/T)GCTGC reference, missense
rs9306515 - 46,707,926(+) TCTGC(A/G)TCCTC reference, missense
rs13057352 - 46,699,338(+) AGACC(A/C)AACCA reference, missense
rs16868 -- 46,694,199(-) AGCTG(C/T)GCCTT intron-variant
rs17151 -- 46,694,336(-) CAGTG(C/T)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CERK Gene

Variant ID Type Subtype PubMed ID
nsv829281 CNV Gain 20364138
nsv829293 CNV Gain 20364138
nsv834227 CNV Loss 17160897
dgv5017n71 CNV Loss 21882294
dgv5018n71 CNV Loss 21882294
nsv915373 CNV Loss 21882294
dgv5020n71 CNV Loss 21882294
nsv915376 CNV Loss 21882294
esv2724451 CNV Deletion 23290073
esv2022578 CNV Deletion 18987734
esv2724452 CNV Deletion 23290073
nsv191421 CNV Loss 16902084
esv2724453 CNV Deletion 23290073
nsv915377 CNV Loss 21882294
esv2673353 CNV Deletion 23128226

Variation tolerance for CERK Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CERK Gene

Human Gene Mutation Database (HGMD)
CERK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERK Gene

Disorders for CERK Gene

MalaCards: The human disease database

(1) MalaCards diseases for CERK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search CERK in MalaCards View complete list of genes associated with diseases

Relevant External Links for CERK

Genetic Association Database (GAD)
CERK
Human Genome Epidemiology (HuGE) Navigator
CERK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CERK
genes like me logo Genes that share disorders with CERK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CERK Gene

Publications for CERK Gene

  1. Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. (PMID: 11956206) Sugiura M. … Kohama T. (J. Biol. Chem. 2002) 2 3 4 67
  2. Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer. (PMID: 19125296) RuckhAoberle E. … Kaufmann M. (J. Cancer Res. Clin. Oncol. 2009) 3 23
  3. Subcellular localization of ceramide kinase and ceramide kinase-like protein requires interplay of their Pleckstrin Homology domain- containing N-terminal regions together with C-terminal domains. (PMID: 19501188) Rovina P. … Bornancin F. (Biochim. Biophys. Acta 2009) 3 23
  4. JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2. (PMID: 19778898) Gubern A. … Claro E. (J. Biol. Chem. 2009) 3 23
  5. Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells. (PMID: 18156590) Hinkovska-Galcheva V. … Boxer L.A. (J. Lipid Res. 2008) 3 23

Products for CERK Gene

Sources for CERK Gene

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