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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CERK Gene

protein-coding GIFtS: 59
GCID: GC22M047080

ceramide kinase

Explore 11 diseases affiliated with
CERK via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ceramide Kinase¹ ²		Lipid Kinase 4² ³
LK4¹ ² ³		DKFZp434E0211¹
HCERK¹		FLJ21430¹
DA59H18.2¹		FLJ23239¹
DA59H18.3¹		Lipid Kinase LK4²
KIAA1646¹ ³		EC 2.7.1.138³
Acylsphingosine Kinase² ³

External Ids:	HGNC: 19256¹	Entrez Gene: 64781²	Ensembl: ENSG00000100422⁷	OMIM: 610307⁵	UniProtKB: Q8TCT0³

Export aliases for CERK gene to outside databases

Previous GC identifers: GC22M043648 GC22M045292 GC22M045400 GC22M030025

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CERK:

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated

in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006

(PubMed 16488390)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: CERK1_HUMAN, Q8TCT0

Function: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on

natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and

C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides

summary for CERK:

Ceramide kinase catalyzes the addition of a phosphate group to ceramide, generating ceramide-1-phosphate.

Gene Wiki entry for CERK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CERK gene promoter:
c-Fos Pax-5 AP-1 ATF-2 Nkx2-5 c-Jun GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CERK promoter sequence

Search SABiosciences Chromatin IP Primers for CERK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CERK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31 Ensembl cytogenetic band: 22q13.31 HGNC cytogenetic band: 22q13.31

CERK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CERK gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M047080: view genomic region (about GC identifiers)

Start:	47,080,307 bp from pter	End:	47,134,158 bp from pter
Size:	53,852 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CERK1_HUMAN, Q8TCT0 (See protein sequence)

Recommended Name: Ceramide kinase

Size: 537 amino acids; 59977 Da

Cofactor: Calcium

Cofactor: Magnesium

Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein

Secondary accessions: A0JNT4 A8K611 Q9BYB3 Q9UGE5

Explore the universe of human proteins at neXtProt for CERK: NX_Q8TCT0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8TCT0

CERK Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_073603.2

ENSEMBL proteins:

ENSP00000216264 ENSP00000400859 ENSP00000438659

Reactome Protein details: Q8TCT0
Human Recombinant Protein Products for CERK:

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	Uscn Proteins for CERK

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000299	integral to membrane of membrane fraction	--	--
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005739	mitochondrion	IEA	--
GO:0005886	plasma membrane	TAS	--

CERK for ontologies About GeneDecksing

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Assay Products for CERK:

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	Uscn ELISAs and CLIAs for CERK

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CERK for domains About GeneDecksing

2 InterPro domains/families:

IPR001206 Diacylglycerol_kinase_cat_dom

IPR001849 Pleckstrin_homology

Graphical View of Domain Structure for InterPro Entry Q8TCT0

ProtoNet protein and cluster: Q8TCT0

1 Blocks protein family: IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: CERK1_HUMAN, Q8TCT0

Similarity: Contains 1 DAGKc domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CERK1_HUMAN, Q8TCT0

Function: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on

natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and

C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides

Catalytic activity: ATP + ceramide = ADP + ceramide 1-phosphate

Enzyme regulation: Inhibited by sulfatide

Biophysicochemical properties: pH dependence: Optimum pH is 6.0-7.5;

Enzyme Number (IUBMB): EC 2.7.1.138¹

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IDA	10947957
GO:0001729	ceramide kinase activity	IDA	19501188
GO:0004143	diacylglycerol kinase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0005543	phospholipid binding	IEA	--

CERK for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for CERK:

Increased apoptosis

Increased cell death in HCC-19

Increased telomerase activity

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cerk):

behavior/neurological	digestive/alimentary	growth/size	hematopoietic system	immune system
mortality/aging

CERK for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for CERK: Cerk^tm1Fbor Cerk^tm1Yiga

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CERK

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		SwitchGear 3'UTR luciferase reporter plasmid: CERK 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERK

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Sphingolipid metabolism

	Sphingolipid metabolism	1.00			Sphingolipid metabolism	0.54
	Glycosphingolipid metabolism	0.54

TNF-Induced Apoptosis Implicating Sphingolipids

TNF-Induced Apoptosis Implicating Sphingolipids

1.00

Ceramide Pathway

0.32

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Integrated Breast Cancer Pathway

Integrated Breast Cancer Pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CERK

	Ceramide Pathway
	TNF-Induced Apoptosis Implicating Sphingolipids

1 BioSystems Pathway for CERK

Integrated Breast Cancer Pathway

4 Reactome Pathways for CERK

	Sphingolipid metabolism
	Glycosphingolipid metabolism
	Metabolism
	Metabolism of lipids and lipoproteins

1 Kegg Pathway (Kegg details for CERK):

Sphingolipid metabolism

CERK for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CERK

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/19 Interacting proteins for CERK (Q8TCT0³ ENSP00000216264⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP6R1	Q9UPN7³	I2D: score=5
ACER1	ENSP00000301452⁴	STRING: ENSP00000301452
ACER2	ENSP00000342609⁴	STRING: ENSP00000342609
ASAH1	ENSP00000371152⁴	STRING: ENSP00000371152
ASAH2	ENSP00000378897⁴	STRING: ENSP00000378897

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006665	sphingolipid metabolic process	TAS	--
GO:0006672	ceramide metabolic process	TAS	11956206
GO:0006687	glycosphingolipid metabolic process	TAS	--
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	IEA	--

CERK for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CERK for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for CERK available from Tocris Bioscience About this table

Compound	Action	CAS #
NVP 231	Potent, selective and reversible CerK inhibitor	[362003-83-6]

10/39 HMDB Compounds for CERK (see all 39) About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Calcium	Ca (see all 2)	7440-70-2	--
Cer(d18:0/12:0)		--	--
Cer(d18:0/14:0)		--	--
Cer(d18:0/16:0)		--	--
Cer(d18:0/18:0)		--	--
Cer(d18:0/18:1(11Z))		--	--
Cer(d18:0/18:1(9Z))		--	--
Cer(d18:0/20:0)		--	--

9 Novoseek chemical compound relationships for CERK gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ceramide 1-phosphate	98.6	85	12855693 (4), 19101626 (3), 16488390 (3), 17392267 (3) (see all 32)
ceramide	92.8	196	12855693 (6), 12927832 (6), 18206978 (5), 19101626 (4) (see all 62)
sphingosine	79.9	10	16170208 (2), 15585321 (2), 13129923 (1), 17351295 (1) (see all 8)
c2ceramide	75.7	3	17338639 (2)
ceramides	73.2	7	19101626 (2), 18831956 (2), 16170208 (1), 12927832 (1)
lipid	48.2	19	12927832 (3), 15899891 (2), 17351295 (1), 15464297 (1) (see all 10)
arachidonic acid	31.1	7	12855693 (4), 19101626 (2), 14676210 (1)
calcium	20.4	12	8245978 (2), 18156590 (2), 14769792 (2), 16203736 (1) (see all 6)
atp	12.4	1	18206978 (1)

Search CenterWatch for drugs/clinical trials and news about CERK / CERK1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CERK gene (2 alternative transcripts):

NM_182661.1 NM_022766.5

Unigene Cluster for CERK:

Ceramide kinase

Hs.200668 [show with all ESTs]

Unigene Representative Sequence: NM_022766

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000216264(uc010hae.3 uc003bia.3) ENST00000443629 ENST00000471929

ENST00000460254 ENST00000541677

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Additional cDNA sequence:

AB051433.1 AB079066.1 AJ457828.1 AK025083.1 AK026892.1 AK291476.1 AL137600.1 AL832794.1

AY927550.1 BC004278.1 BC008382.1 BC067255.1 BC108712.1 BC126940.1 CR456404.1 CR457365.1

11 DOTS entries:

DT.441741 DT.99929377 DT.95198581 DT.95211276 DT.99976536 DT.100784669 DT.95268094 DT.97785411

DT.99928430 DT.120647370 DT.91699418

24/189 AceView cDNA sequences (see all 189):

BX952302 AK026892 AI679943 AI610717 AI679433 CR597559 CA443049 AI299775

AL137600 BC004278 BM737702 AI694771 CD631565 BM846741 AK025083 BM697053

BM479389 H55199 H55443 NM_022766 CR609594 AI131493 AA682589 AA679575

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CERK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGGTTCCT

About this image

CERK expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Cervical Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Sacral Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Thoracic Intervertebral Disc

Intervertebral Disc Annulus Fibrosus Cells

Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CERK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CERK

SOURCE GeneReport for Unigene cluster: Hs.200668

UniProtKB/Swiss-Prot: CERK1_HUMAN, Q8TCT0

Tissue specificity: High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral

blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CERK

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERK gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CERK¹	ceramide kinase	67.51(n) 67.9(a)		425523 NM_001031340.1 NP_001026511.1
lizard (Anolis carolinensis)	Reptilia	CERK⁶	--	64(a)	1 ↔ 1	5(72566676-72596368)
African clawed frog (Xenopus laevis)	Amphibia	Xl.9645²	Xenopus laevis transcribed sequence with weak similarity more	70.98(n)		BJ615281.1
zebrafish (Danio rerio)	Actinopterygii	cerk¹	ceramide kinase	62.57(n) 59.82(a)		558496 NM_001105586.1 NP_001099056.1
fruit fly (Drosophila melanogaster)	Insecta	Cerk¹	Ceramide kinase	46.82(n) 40.92(a)		40640 NM_141273.2 NP_649530.2
worm (Caenorhabditis elegans)	Secernentea	T10B11.2¹	Protein T10B11.2	43.89(n) 35.16(a)		172423 NM_059576.3 NP_491977.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G51290¹	diacylglycerol kinase family protein	47.23(n) 40.48(a)		835203 NM_124508.3 NP_568756.2
rice (Oryza sativa)	Liliopsida	--	ceramide kinase-related, putative, expressed	30(a)	1 ↔ 1	2(26498487-26501649)

ENSEMBL Gene Tree for CERK (if available)
TreeFam Gene Tree for CERK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CERK gene

CERKL² SPHK1² SPHK2² AGK²

CERK for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183757352^1,2		--	47079839(+)	`AGGCAA/GGAGAA`	1	--	ds500¹		0	--	--	--	--
rs140168677^1,2		--	47079848(+)	`AATGGC/TGTGAA`	1	--	ds500¹		0	--	--	--	--
rs4823571^1,2	A	--	47079863(+)	`GGAGGC/TGAGCT`	1	--	ds500¹		0	--	--	--	--
rs146835537^1,2		--	47079876(+)	`CAGTGA/GGCCAA`	1	--	ds500¹		0	--	--	--	--
rs140660251^1,2		--	47079904(+)	`ATTGCA/GCCACT`	1	--	ds500¹		0	--	--	--	--
rs141969534^1,2		--	47079941(+)	`AACTCC/TGTCTC`	1	--	ds500¹		0	--	--	--	--
rs112631878^1,2		--	47080011(+)	`AACACG/ATTTCC`	1	--	ds500¹		1		CSA	2
rs188478515^1,2		--	47080017(+)	`TTTCCC/TTTGGA`	1	--	ds500¹		0	--	--	--	--
rs801724^1,2	C,F,O,A,H	--	47080026(-)	`TGCTCT/CTTATC`	1	--	ds500¹		22		NS EA WA NA CSA	2348
rs111874617^1,2	C	--	47080035(+)	`CAAAAC/GCTGCA`	1	--	ds500¹		2		NA WA	120

HapMap Linkage Disequilibrium report for CERK (47080307 - 47134158 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CERK
1 CNV: 5190

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CERK for disorders           About GeneDecksing

OMIM gene information: 610307    OMIM disorders: --

11 diseases for CERK:    About MalaCards

retinitis pigmentosa retinal degeneration retinitis lung adenocarcinoma

adenocarcinoma prostate cancer breast cancer neuroblastoma

prostatitis malaria leukemia

2 Novoseek disease relationships for CERK gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinitis pigmentosa	55.3	1	16581028 (1)
inflammation	3.38	1	18691014 (1)

Human Genome Epidemiology (HuGE) Navigator: CERK (2 documents)

Export disorders for CERK gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CERK gene, integrated from 9 sources (see all 80):
(articles sorted by number of sources associating them with CERK)

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Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. (PubMed id 11956206)^{1, 2, 3} Sugiura M....Kohama T. (2002)
Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)^{1, 2, 3} Hirosawa M....Ohara O. (2001)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Substrate specificity of human ceramide kinase. (PubMed id 16170208)^{1, 9} Wijesinghe D.S....Chalfant C.E. (2005)
Subcellular localization of ceramide kinase and ceram ide kinase-like protein requires interplay of their Pleckstrin Homology domain- containing N-terminal regions together with C-terminal domains. (PubMed id 19501188)^{1, 9} Rovina P....Bornancin F. (2009)
The interaction between the pleckstrin homology domain of ceramide kinase and phosphatidylinositol 4,5-bisphosphate regulates the plasma membrane targeting and ceramide 1-phosphate levels. (PubMed id 16488390)^{1, 9} Kim T.J....Igarashi Y. (2006)
Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cells. (PubMed id 18156590)^{1, 9} Hinkovska-Galcheva V....Boxer L.A. (2008)
Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis. (PubMed id 17392267)^{1, 9} Lamour N.F....Chalfant C.E. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 64781	HGNC: 19256	AceView: CERK	Ensembl:ENSG00000100422	euGenes: HUgn64781
ECgene: CERK	Kegg: 64781	H-InvDB: CERK

(According to HUGE)
About This Section

HUGE: KIAA1646

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CERK	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CERK gene
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Patent Information for CERK gene:
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