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Aliases for CERK Gene

Aliases for CERK Gene

  • Ceramide Kinase 2 3
  • Acylsphingosine Kinase 3 4
  • Lipid Kinase 4 3 4
  • KIAA1646 4 6
  • HCERK 3 4
  • LK4 3 4
  • Lipid Kinase LK4 3
  • EC 2.7.1.138 4
  • DA59H18.2 3
  • DA59H18.3 3

External Ids for CERK Gene

Summaries for CERK Gene

Entrez Gene Summary for CERK Gene

  • CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CERK Gene

CERK (Ceramide Kinase) is a Protein Coding gene. Diseases associated with CERK include retinitis pigmentosa. Among its related pathways are Sphingolipid metabolism and Sphingolipid metabolism. GO annotations related to this gene include phospholipid binding and NAD+ kinase activity. An important paralog of this gene is SPHK2.

UniProtKB/Swiss-Prot for CERK Gene

  • Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

Tocris Summary for CERK Gene

  • Ceramide kinase catalyzes the addition of a phosphate group to ceramide, generating ceramide-1-phosphate.

Gene Wiki entry for CERK Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERK Gene

Genomics for CERK Gene

Genomic Location for CERK Gene

Start:
46,684,410 bp from pter
End:
46,738,261 bp from pter
Size:
53,852 bases
Orientation:
Minus strand

Genomic View for CERK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CERK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERK Gene

Regulatory Elements for CERK Gene

Proteins for CERK Gene

  • Protein details for CERK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCT0-CERK1_HUMAN
    Recommended name:
    Ceramide kinase
    Protein Accession:
    Q8TCT0
    Secondary Accessions:
    • A0JNT4
    • A8K611
    • Q6NX59
    • Q9BYB3
    • Q9UGE5

    Protein attributes for CERK Gene

    Size:
    537 amino acids
    Molecular mass:
    59977 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CERK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CERK Gene

Proteomics data for CERK Gene at MOPED

Post-translational modifications for CERK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CERK Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CERK Gene

Domains for CERK Gene

Protein Domains for CERK Gene

UniProtKB/Swiss-Prot:

CERK1_HUMAN
Domain:
  • Contains 1 DAGKc domain.:
    • Q8TCT0
genes like me logo Genes that share domains with CERK: view

No data available for Gene Families for CERK Gene

Function for CERK Gene

Molecular function for CERK Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 6.0-7.5.;
UniProtKB/Swiss-Prot CatalyticActivity: ATP + ceramide = ADP + ceramide 1-phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by sulfatide.
UniProtKB/Swiss-Prot Function: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

Enzyme Numbers (IUBMB) for CERK Gene

Gene Ontology (GO) - Molecular Function for CERK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 10947957
GO:0001729 ceramide kinase activity IDA 11956206
GO:0003951 NAD+ kinase activity IEA --
GO:0004143 diacylglycerol kinase activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CERK: view
genes like me logo Genes that share phenotypes with CERK: view

Animal Models for CERK Gene

MGI Knock Outs for CERK:

miRNA for CERK Gene

No data available for Transcription Factor Targeting and HOMER Transcription for CERK Gene

Localization for CERK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERK Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CERK Gene COMPARTMENTS Subcellular localization image for CERK gene
Compartment Confidence
nucleus 4
plasma membrane 4
cytosol 3
golgi apparatus 2
mitochondrion 2
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CERK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IDA 11956206
genes like me logo Genes that share ontologies with CERK: view

Pathways for CERK Gene

genes like me logo Genes that share pathways with CERK: view

Pathways by source for CERK Gene

Gene Ontology (GO) - Biological Process for CERK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006665 sphingolipid metabolic process TAS --
GO:0006672 ceramide metabolic process TAS 11956206
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with CERK: view

Compounds for CERK Gene

(5) Tocris Compounds for CERK Gene

Compound Action Cas Number
(5Z)-7-Oxozeaenol Potent and selective TAK1 MAPKKK inhibitor [66018-38-0]
AZ 3146 Potent and selective monopolar spindle 1 (Mps1) kinase inhibitor [1124329-14-1]
CGP 57380 Selective inhibitor of Mnk1 [522629-08-9]
GSK 650394 Serum- and glucocorticoid-regulated kinase (SGK) inhibitor [890842-28-1]
IPA 3 Group I p21-activated kinase (PAK) inhibitor [42521-82-4]

(39) HMDB Compounds for CERK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
Cer(d18:0/12:0)
Not Available
Cer(d18:0/14:0)
Not Available

(9) Novoseek inferred chemical compound relationships for CERK Gene

Compound -log(P) Hits PubMed IDs
ceramide 1-phosphate 98.6 47
ceramide 92.8 124
sphingosine 79.9 10
c2ceramide 75.7 2
ceramides 73.2 6
genes like me logo Genes that share compounds with CERK: view

Transcripts for CERK Gene

Unigene Clusters for CERK Gene

Ceramide kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CERK Gene

No ASD Table

Relevant External Links for CERK Gene

GeneLoc Exon Structure for
CERK
ECgene alternative splicing isoforms for
CERK

Expression for CERK Gene

mRNA expression in normal human tissues for CERK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CERK Gene

SOURCE GeneReport for Unigene cluster for CERK Gene Hs.200668

mRNA Expression by UniProt/SwissProt for CERK Gene

Q8TCT0-CERK1_HUMAN
Tissue specificity: High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung
genes like me logo Genes that share expressions with CERK: view

Orthologs for CERK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CERK 36
  • 99.38 (n)
  • 99.63 (a)
CERK 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CERK 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CERK 36
  • 82.94 (n)
  • 87.5 (a)
CERK 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cerk 36
  • 81.41 (n)
  • 84.88 (a)
Cerk 16
Cerk 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CERK 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CERK 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cerk 36
  • 82.17 (n)
  • 85.82 (a)
chicken
(Gallus gallus)
Aves CERK 36
  • 67.38 (n)
  • 67.19 (a)
CERK 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CERK 37
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9645 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487080 36
  • 62.95 (n)
  • 62.12 (a)
Str.10087 36
zebrafish
(Danio rerio)
Actinopterygii cerk 36
  • 62.95 (n)
  • 60.36 (a)
cerk 37
  • 43 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002932 36
  • 48.28 (n)
  • 42.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cerk 36
  • 47.05 (n)
  • 41.15 (a)
Cerk 37
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T10B11.2 36
  • 44.44 (n)
  • 35.9 (a)
T10B11.2 37
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LCB4 37
  • 13 (a)
ManyToMany
LCB5 37
  • 13 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51290 36
  • 47.12 (n)
  • 42.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 38 (a)
OneToOne
Species with no ortholog for CERK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERK Gene

ENSEMBL:
Gene Tree for CERK (if available)
TreeFam:
Gene Tree for CERK (if available)

Paralogs for CERK Gene

Paralogs for CERK Gene

genes like me logo Genes that share paralogs with CERK: view

Variants for CERK Gene

Sequence variations from dbSNP and Humsavar for CERK Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs16868 -- 46,694,199(-) AGCTG(C/T)GCCTT intron-variant
rs17151 -- 46,694,336(-) CAGTG(C/T)AAATA intron-variant
rs78424 -- 46,697,949(+) TGGTC(A/G)GGTAA intron-variant
rs85598 -- 46,707,010(-) AAGGC(C/T)AGCCC intron-variant
rs135663 -- 46,687,323(+) GCTGG(-/C)CCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CERK Gene

Variant ID Type Subtype PubMed ID
nsv829281 CNV Gain 20364138
nsv829293 CNV Gain 20364138
nsv834227 CNV Loss 17160897
dgv5017n71 CNV Loss 21882294
dgv5018n71 CNV Loss 21882294
nsv915373 CNV Loss 21882294
dgv5020n71 CNV Loss 21882294
nsv915376 CNV Loss 21882294
esv2724451 CNV Deletion 23290073
esv2022578 CNV Deletion 18987734
esv2724452 CNV Deletion 23290073
nsv191421 CNV Loss 16902084
esv2724453 CNV Deletion 23290073
nsv915377 CNV Loss 21882294
esv2673353 CNV Deletion 23128226

Relevant External Links for CERK Gene

HapMap Linkage Disequilibrium report
CERK
Human Gene Mutation Database (HGMD)
CERK

Disorders for CERK Gene

(1) MalaCards Diseases for CERK Gene

Search for CERK Gene in MalaCards »

(2) Novoseek inferred disease relationships for CERK Gene

Disease -log(P) Hits PubMed IDs
retinitis pigmentosa 55.3 1
inflammation 3.38 1

Relevant External Links for CERK

Genetic Association Database (GAD)
CERK
Human Genome Epidemiology (HuGE) Navigator
CERK
genes like me logo Genes that share disorders with CERK: view

No data available for UniProtKB/Swiss-Prot for CERK Gene

Publications for CERK Gene

  1. The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity. (PMID: 16081073) Kim T.J. … Igarashi Y. (FEBS Lett. 2005) 3 4 23
  2. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M. … Ohara O. (DNA Res. 2001) 2 3 4
  3. Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. (PMID: 11956206) Sugiura M. … Kohama T. (J. Biol. Chem. 2002) 2 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CERK Gene

  • Addgene plasmids for CERK

Sources for CERK Gene

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