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Aliases for CERK Gene

Aliases for CERK Gene

  • Ceramide Kinase 2 3 5
  • Acylsphingosine Kinase 3 4
  • Lipid Kinase 4 3 4
  • HCERK 3 4
  • LK4 3 4
  • Lipid Kinase LK4 3
  • EC 2.7.1.138 4
  • DA59H18.2 3
  • DA59H18.3 3
  • KIAA1646 4

External Ids for CERK Gene

Previous GeneCards Identifiers for CERK Gene

  • GC22M043648
  • GC22M045292
  • GC22M045400
  • GC22M047080
  • GC22M030025

Summaries for CERK Gene

Entrez Gene Summary for CERK Gene

  • CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CERK Gene

CERK (Ceramide Kinase) is a Protein Coding gene. Diseases associated with CERK include Retinitis Pigmentosa. Among its related pathways are Integrated Breast Cancer Pathway and Metabolism. GO annotations related to this gene include magnesium ion binding and diacylglycerol kinase activity. An important paralog of this gene is CERKL.

UniProtKB/Swiss-Prot for CERK Gene

  • Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

Tocris Summary for CERK Gene

Gene Wiki entry for CERK Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERK Gene

Genomics for CERK Gene

Regulatory Elements for CERK Gene

Enhancers for CERK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F046648 1.3 VISTA FANTOM5 Ensembl ENCODE 12.6 +86.7 86748 5.4 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 SP5 MXD4 PPARG CERK CELSR1 ENSG00000234869 GRAMD4 PPARA TTC38 GC22M046648 GC22P046654
GH22F046798 0.6 ENCODE 12.1 -59.8 -59838 0.1 TBC1D22A CERK GC22P046798 GC22P046799 GC22P046797 GC22P046796 GC22P046815
GH22F046799 0.8 ENCODE 12.1 -60.5 -60529 1.1 MLX ARID4B DMAP1 ZNF48 ZNF2 YY1 SLC30A9 ZNF143 MXD4 MIER2 TBC1D22A ENSG00000260708 CERK GC22P046798 GC22P046799 GC22P046797 GC22P046796 GC22P046815
GH22F046733 0.5 ENCODE 10.7 -1.2 -1239 11.5 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000260708 CERK GC22M046764
GH22F046573 0.8 FANTOM5 ENCODE 6.2 +159.9 159929 10.3 PKNOX1 ARID4B FEZF1 YBX1 ZNF48 YY1 SLC30A9 GLIS2 ELK1 ZNF143 GRAMD4 ENSG00000234869 CERK GC22M046648
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CERK on UCSC Golden Path with GeneCards custom track

Promoters for CERK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000619852 261 2401 PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 SP3 SP5

Genomic Location for CERK Gene

Chromosome:
22
Start:
46,684,410 bp from pter
End:
46,738,261 bp from pter
Size:
53,852 bases
Orientation:
Minus strand

Genomic View for CERK Gene

Genes around CERK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERK Gene

Proteins for CERK Gene

  • Protein details for CERK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCT0-CERK1_HUMAN
    Recommended name:
    Ceramide kinase
    Protein Accession:
    Q8TCT0
    Secondary Accessions:
    • A0JNT4
    • A8K611
    • Q6NX59
    • Q9BYB3
    • Q9UGE5

    Protein attributes for CERK Gene

    Size:
    537 amino acids
    Molecular mass:
    59977 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CERK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CERK Gene

Post-translational modifications for CERK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CERK Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CERK Gene

Domains & Families for CERK Gene

Protein Domains for CERK Gene

Suggested Antigen Peptide Sequences for CERK Gene

Graphical View of Domain Structure for InterPro Entry

Q8TCT0

UniProtKB/Swiss-Prot:

CERK1_HUMAN :
  • Contains 1 DAGKc domain.
Domain:
  • Contains 1 DAGKc domain.
genes like me logo Genes that share domains with CERK: view

No data available for Gene Families for CERK Gene

Function for CERK Gene

Molecular function for CERK Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.0-7.5.;
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + ceramide = ADP + ceramide 1-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by sulfatide.
UniProtKB/Swiss-Prot Function:
Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

Enzyme Numbers (IUBMB) for CERK Gene

Gene Ontology (GO) - Molecular Function for CERK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 10947957
GO:0001729 ceramide kinase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with CERK: view
genes like me logo Genes that share phenotypes with CERK: view

Animal Models for CERK Gene

MGI Knock Outs for CERK:

Animal Model Products

  • Taconic Biosciences Mouse Models for CERK

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CERK

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CERK Gene

Localization for CERK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERK Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CERK Gene COMPARTMENTS Subcellular localization image for CERK gene
Compartment Confidence
plasma membrane 5
mitochondrion 3
cytosol 2
golgi apparatus 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CERK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA 11956206
genes like me logo Genes that share ontologies with CERK: view

Pathways & Interactions for CERK Gene

genes like me logo Genes that share pathways with CERK: view

Pathways by source for CERK Gene

Gene Ontology (GO) - Biological Process for CERK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006672 ceramide metabolic process TAS 11956206
GO:0006687 glycosphingolipid metabolic process TAS --
GO:0016310 phosphorylation IEA --
GO:0046834 lipid phosphorylation IEA --
genes like me logo Genes that share ontologies with CERK: view

No data available for SIGNOR curated interactions for CERK Gene

Drugs & Compounds for CERK Gene

(9) Drugs for CERK Gene - From: ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
NVP 231 Pharma CerK inhibitor 0
calcium Nutra 0
Magnesium Nutra 0
GSK 650394 Pharma SGK1 inhibitor, Serum- and glucocorticoid-regulated kinase (SGK) inhibitor 0

(38) Additional Compounds for CERK Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Cer(d18:0/12:0)
Cer(d18:0/14:0)
Cer(d18:0/16:0)
Cer(d18:0/18:0)

(5) Tocris Compounds for CERK Gene

Compound Action Cas Number
(5Z)-7-Oxozeaenol Potent and selective TAK1 MAPKKK inhibitor 66018-38-0
GSK 650394 Serum- and glucocorticoid-regulated kinase (SGK) inhibitor 890842-28-1
SB 747651A dihydrochloride Potent MSK1 inhibitor; also inhibits other AGC group kinases
TNP Inhibitor of IP6K; also inhibits IP3K 519178-28-0
UNC 3230 Potent and selective PIP5K1C inhibitor; antinociceptive 1031602-63-7

(1) ApexBio Compounds for CERK Gene

Compound Action Cas Number
NVP 231 CerK inhibitor 362003-83-6
genes like me logo Genes that share compounds with CERK: view

Transcripts for CERK Gene

Unigene Clusters for CERK Gene

Ceramide kinase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CERK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CERK Gene

No ASD Table

Relevant External Links for CERK Gene

GeneLoc Exon Structure for
CERK
ECgene alternative splicing isoforms for
CERK

Expression for CERK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CERK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CERK Gene

This gene is overexpressed in Urine (41.5) and Lung (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CERK Gene



Protein tissue co-expression partners for CERK Gene

NURSA nuclear receptor signaling pathways regulating expression of CERK Gene:

CERK

SOURCE GeneReport for Unigene cluster for CERK Gene:

Hs.200668

mRNA Expression by UniProt/SwissProt for CERK Gene:

Q8TCT0-CERK1_HUMAN
Tissue specificity: High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.
genes like me logo Genes that share expression patterns with CERK: view

Primer Products

No data available for mRNA differential expression in normal tissues for CERK Gene

Orthologs for CERK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CERK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CERK 34 35
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia CERK 34 35
  • 82.94 (n)
rat
(Rattus norvegicus)
Mammalia Cerk 34
  • 82.17 (n)
mouse
(Mus musculus)
Mammalia Cerk 34 16 35
  • 81.41 (n)
cow
(Bos Taurus)
Mammalia CERK 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CERK 35
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CERK 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves CERK 34 35
  • 67.38 (n)
lizard
(Anolis carolinensis)
Reptilia CERK 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487080 34
  • 62.95 (n)
Str.10087 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.9645 34
zebrafish
(Danio rerio)
Actinopterygii cerk 34 35
  • 62.95 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002932 34
  • 48.28 (n)
fruit fly
(Drosophila melanogaster)
Insecta Cerk 34 35
  • 47.05 (n)
worm
(Caenorhabditis elegans)
Secernentea T10B11.2 34 35
  • 44.44 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LCB4 35
  • 13 (a)
ManyToMany
LCB5 35
  • 13 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G51290 34
  • 47.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 38 (a)
OneToOne
Species where no ortholog for CERK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERK Gene

ENSEMBL:
Gene Tree for CERK (if available)
TreeFam:
Gene Tree for CERK (if available)

Paralogs for CERK Gene

Paralogs for CERK Gene

genes like me logo Genes that share paralogs with CERK: view

Variants for CERK Gene

Sequence variations from dbSNP and Humsavar for CERK Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1047123 -- 46,684,904(-) ACATT(C/G)AGAAT utr-variant-3-prime
rs10583580 -- 46,719,150(+) CTTTG(-/GT/TG)TGTGT intron-variant
rs10638550 -- 46,737,300(+) AAAAA(-/AC/CA)AAAAA intron-variant, upstream-variant-2KB
rs10640863 -- 46,719,148(+) CACTT(-/TG)TGTGT intron-variant
rs11090891 -- 46,727,453(+) TCTTT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CERK Gene

Variant ID Type Subtype PubMed ID
dgv2469n106 OTHER inversion 24896259
esv2022578 CNV deletion 18987734
esv2673353 CNV deletion 23128226
esv2724451 CNV deletion 23290073
esv2724452 CNV deletion 23290073
esv2724453 CNV deletion 23290073
esv3558271 CNV deletion 23714750
esv3647960 CNV loss 21293372
esv3647961 CNV loss 21293372
esv3647962 CNV loss 21293372
nsv1060721 CNV gain 25217958
nsv1122058 CNV deletion 24896259
nsv1123607 CNV deletion 24896259
nsv1152661 OTHER inversion 26484159
nsv191421 CNV deletion 16902084
nsv589137 CNV gain 21841781
nsv829281 CNV gain 20364138
nsv829293 CNV gain 20364138
nsv834227 CNV loss 17160897
nsv955179 CNV deletion 24416366

Variation tolerance for CERK Gene

Residual Variation Intolerance Score: 80.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.08; 60.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CERK Gene

Human Gene Mutation Database (HGMD)
CERK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CERK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERK Gene

Disorders for CERK Gene

MalaCards: The human disease database

(1) MalaCards diseases for CERK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search CERK in MalaCards View complete list of genes associated with diseases

Relevant External Links for CERK

Genetic Association Database (GAD)
CERK
Human Genome Epidemiology (HuGE) Navigator
CERK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CERK
genes like me logo Genes that share disorders with CERK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CERK Gene

Publications for CERK Gene

  1. The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity. (PMID: 16081073) Kim T.J. … Igarashi Y. (FEBS Lett. 2005) 3 4 22 64
  2. Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization. (PMID: 11956206) Sugiura M. … Kohama T. (J. Biol. Chem. 2002) 2 3 4 64
  3. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PMID: 11258795) Hirosawa M. … Ohara O. (DNA Res. 2001) 2 3 4 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. Ceramide kinase profiling by mass spectrometry reveals a conserved phosphorylation pattern downstream of the catalytic site. (PMID: 19899769) Chen W.Q. … Bornancin F. (J. Proteome Res. 2010) 4 22 64

Products for CERK Gene

Sources for CERK Gene

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