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Aliases for CERCAM Gene

Aliases for CERCAM Gene

  • Cerebral Endothelial Cell Adhesion Molecule 2 3 4
  • Glycosyltransferase 25 Domain Containing 3 2 3
  • Cerebral Cell Adhesion Molecule 2 3
  • CEECAM1 3 4
  • GLT25D3 3 4
  • Probable Inactive Glycosyltransferase 25 Family Member 3 3
  • Cerebral Endothelial Cell Adhesion Molecule 1 3
  • Glycosyltransferase 25 Family Member 3 3
  • KIAA1502 4

External Ids for CERCAM Gene

Previous HGNC Symbols for CERCAM Gene


Previous GeneCards Identifiers for CERCAM Gene

  • GC09P130214
  • GC09P131174
  • GC09P100795

Summaries for CERCAM Gene

GeneCards Summary for CERCAM Gene

CERCAM (Cerebral Endothelial Cell Adhesion Molecule) is a Protein Coding gene. An important paralog of this gene is COLGALT1.

UniProtKB/Swiss-Prot for CERCAM Gene

  • Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERCAM Gene

Genomics for CERCAM Gene

Regulatory Elements for CERCAM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CERCAM Gene

128,411,575 bp from pter
128,437,351 bp from pter
25,777 bases
Plus strand

Genomic View for CERCAM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CERCAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERCAM Gene

Proteins for CERCAM Gene

  • Protein details for CERCAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable inactive glycosyltransferase 25 family member 3
    Protein Accession:
    Secondary Accessions:
    • A7MD00
    • C4AMA2
    • Q0VDF3
    • Q2VPJ4
    • Q4KMP2
    • Q5T4B1
    • Q8N107
    • Q96EZ5
    • Q9P226
    • Q9UMW5

    Protein attributes for CERCAM Gene

    595 amino acids
    Molecular mass:
    67592 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH98432.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI19699.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI19700.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96026.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11040.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13495.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CERCAM Gene


neXtProt entry for CERCAM Gene

Proteomics data for CERCAM Gene at MOPED

Post-translational modifications for CERCAM Gene

  • Ubiquitination at Lys386 and Lys570
  • Glycosylation at Asn75, Asn153, Asn237, and Asn360
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CERCAM Gene

Domains for CERCAM Gene

Protein Domains for CERCAM Gene

Suggested Antigen Peptide Sequences for CERCAM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5T4B2
  • Belongs to the glycosyltransferase 25 family.
genes like me logo Genes that share domains with CERCAM: view

No data available for Gene Families for CERCAM Gene

Function for CERCAM Gene

Molecular function for CERCAM Gene

UniProtKB/Swiss-Prot Function: Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity.

Phenotypes for CERCAM Gene

GenomeRNAi human phenotypes for CERCAM:
genes like me logo Genes that share phenotypes with CERCAM: view

Animal Model Products

CRISPR Products

miRNA for CERCAM Gene

miRTarBase miRNAs that target CERCAM

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CERCAM Gene

Localization for CERCAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERCAM Gene

Endoplasmic reticulum lumen.

Subcellular locations from

Jensen Localization Image for CERCAM Gene COMPARTMENTS Subcellular localization image for CERCAM gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 3
extracellular 2
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CERCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005886 plasma membrane NAS 10608765
genes like me logo Genes that share ontologies with CERCAM: view

Pathways for CERCAM Gene

SuperPathways for CERCAM Gene

No Data Available

Interacting Proteins for CERCAM Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000361929 Q5T4B2-GT253_HUMAN for CERCAM Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CERCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 10608765
GO:0007155 cell adhesion IDA 10608765
GO:0007159 leukocyte cell-cell adhesion TAS 10608765
GO:0009103 lipopolysaccharide biosynthetic process --
genes like me logo Genes that share ontologies with CERCAM: view

No data available for Pathways by source for CERCAM Gene

Transcripts for CERCAM Gene

Unigene Clusters for CERCAM Gene

Cerebral endothelial cell adhesion molecule:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CERCAM

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CERCAM

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CERCAM Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP5: - - - - -
SP6: - - - -
SP7: -
SP8: - - - - - - - - -
SP9: - -
SP10: - -
SP11: - - - - - - - - -
SP12: -

ExUns: 21 ^ 22 ^ 23

Relevant External Links for CERCAM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CERCAM Gene

mRNA expression in normal human tissues for CERCAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CERCAM Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.3), Brain - Putamen (basal ganglia) (5.0), Brain - Substantia nigra (4.7), and Brain - Hippocampus (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CERCAM Gene

SOURCE GeneReport for Unigene cluster for CERCAM Gene Hs.495230

mRNA Expression by UniProt/SwissProt for CERCAM Gene

Tissue specificity: Ubiquitous. Highly expressed in secretory and nervous tissues.
genes like me logo Genes that share expressions with CERCAM: view

In Situ Assay Products

Orthologs for CERCAM Gene

This gene was present in the common ancestor of animals.

Orthologs for CERCAM Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CERCAM 35
  • 99.33 (n)
  • 98.66 (a)
  • 99 (a)
(Bos Taurus)
Mammalia CERCAM 35
  • 89.04 (n)
  • 90.72 (a)
  • 91 (a)
(Canis familiaris)
Mammalia CERCAM 35
  • 88.89 (n)
  • 90.85 (a)
  • 90 (a)
(Mus musculus)
Mammalia Cercam 35
  • 82.73 (n)
  • 84.11 (a)
Cercam 16
Cercam 36
  • 84 (a)
(Monodelphis domestica)
Mammalia CERCAM 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia CERCAM 36
  • 74 (a)
(Rattus norvegicus)
Mammalia Cercam 35
  • 83.69 (n)
  • 86.27 (a)
(Gallus gallus)
Aves CERCAM 35
  • 72.15 (n)
  • 71.96 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
-- 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488028 35
  • 63.3 (n)
  • 59.92 (a)
(Danio rerio)
Actinopterygii cercam 35
  • 65.31 (n)
  • 63.1 (a)
cercam 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31915 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea D2045.9 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for CERCAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERCAM Gene

Gene Tree for CERCAM (if available)
Gene Tree for CERCAM (if available)

Paralogs for CERCAM Gene

Paralogs for CERCAM Gene

Selected SIMAP similar genes for CERCAM Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CERCAM: view

Variants for CERCAM Gene

Sequence variations from dbSNP and Humsavar for CERCAM Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs6918 -- 128,437,297(+) CAGAC(A/C)TGTTG utr-variant-3-prime
rs7258 -- 128,434,416(-) CGTCC(A/G)AGGTA reference, synonymous-codon
rs7259 -- 128,434,425(-) ACCTG(C/T)TTCCG synonymous-codon, reference
rs1009850 -- 128,431,386(-) TTCAC(G/T)CACTC intron-variant
rs1009851 -- 128,431,326(-) TGTGG(A/G)TGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CERCAM Gene

Variant ID Type Subtype PubMed ID
dgv8294n71 CNV Loss 21882294
dgv8295n71 CNV Loss 21882294
nsv893898 CNV Loss 21882294
dgv1378e199 CNV Deletion 23128226

Relevant External Links for CERCAM Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERCAM Gene

Disorders for CERCAM Gene

Relevant External Links for CERCAM

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with CERCAM: view

No data available for UniProtKB/Swiss-Prot for CERCAM Gene

Publications for CERCAM Gene

  1. Cerebral cell adhesion molecule: a novel leukocyte adhesion determinant on blood-brain barrier capillary endothelium. (PMID: 10608765) Starzyk R.M. … Tuomanen E.I. (J. Infect. Dis. 2000) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for CERCAM Gene

Sources for CERCAM Gene

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