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Aliases for CERCAM Gene

Aliases for CERCAM Gene

  • Cerebral Endothelial Cell Adhesion Molecule 2 3 4 5
  • Glycosyltransferase 25 Domain Containing 3 2 3
  • Cerebral Cell Adhesion Molecule 2 3
  • CEECAM1 3 4
  • GLT25D3 3 4
  • Cerebral Endothelial Cell Adhesion Molecule 1 3
  • Glycosyltransferase 25 Family Member 3 3
  • KIAA1502 4

External Ids for CERCAM Gene

Previous HGNC Symbols for CERCAM Gene

  • CEECAM1

Previous GeneCards Identifiers for CERCAM Gene

  • GC09P130214
  • GC09P131174
  • GC09P100795

Summaries for CERCAM Gene

GeneCards Summary for CERCAM Gene

CERCAM (Cerebral Endothelial Cell Adhesion Molecule) is a Protein Coding gene. An important paralog of this gene is COLGALT1.

UniProtKB/Swiss-Prot for CERCAM Gene

  • Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CERCAM Gene

Genomics for CERCAM Gene

Regulatory Elements for CERCAM Gene

Genomic Location for CERCAM Gene

Chromosome:
9
Start:
128,411,575 bp from pter
End:
128,437,351 bp from pter
Size:
25,777 bases
Orientation:
Plus strand

Genomic View for CERCAM Gene

Genes around CERCAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CERCAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CERCAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CERCAM Gene

Proteins for CERCAM Gene

  • Protein details for CERCAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4B2-GT253_HUMAN
    Recommended name:
    Probable inactive glycosyltransferase 25 family member 3
    Protein Accession:
    Q5T4B2
    Secondary Accessions:
    • A7MD00
    • C4AMA2
    • Q0VDF3
    • Q2VPJ4
    • Q4KMP2
    • Q5T4B1
    • Q8N107
    • Q96EZ5
    • Q9P226
    • Q9UMW5

    Protein attributes for CERCAM Gene

    Size:
    595 amino acids
    Molecular mass:
    67592 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH98432.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI19699.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI19700.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96026.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11040.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13495.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CERCAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CERCAM Gene

Proteomics data for CERCAM Gene at MOPED

Post-translational modifications for CERCAM Gene

  • Ubiquitination at Lys 386 and Lys 570
  • Glycosylation at Asn 75, Asn 153, Asn 237, and Asn 360
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CERCAM Gene

Domains & Families for CERCAM Gene

Protein Domains for CERCAM Gene

Suggested Antigen Peptide Sequences for CERCAM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T4B2

UniProtKB/Swiss-Prot:

GT253_HUMAN :
  • Belongs to the glycosyltransferase 25 family.
Family:
  • Belongs to the glycosyltransferase 25 family.
genes like me logo Genes that share domains with CERCAM: view

No data available for Gene Families for CERCAM Gene

Function for CERCAM Gene

Molecular function for CERCAM Gene

UniProtKB/Swiss-Prot Function:
Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity.
genes like me logo Genes that share phenotypes with CERCAM: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CERCAM Gene

Localization for CERCAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CERCAM Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CERCAM Gene COMPARTMENTS Subcellular localization image for CERCAM gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 4
extracellular 2
nucleus 2
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CERCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane NAS 10608765
genes like me logo Genes that share ontologies with CERCAM: view

Pathways & Interactions for CERCAM Gene

SuperPathways for CERCAM Gene

No Data Available

Interacting Proteins for CERCAM Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000361929%0d%0a9606.ENSP00000318165%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000357484%0d%0a
Selected Interacting proteins: Q5T4B2-GT253_HUMAN ENSP00000361929 for CERCAM Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CERCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 10608765
genes like me logo Genes that share ontologies with CERCAM: view

No data available for Pathways by source and SIGNOR curated interactions for CERCAM Gene

Drugs & Compounds for CERCAM Gene

No Compound Related Data Available

Transcripts for CERCAM Gene

Unigene Clusters for CERCAM Gene

Cerebral endothelial cell adhesion molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CERCAM Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - - - - -
SP6: - - - -
SP7: -
SP8: - - - - - - - - -
SP9: - -
SP10: - -
SP11: - - - - - - - - -
SP12: -

ExUns: 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for CERCAM Gene

GeneLoc Exon Structure for
CERCAM
ECgene alternative splicing isoforms for
CERCAM

Expression for CERCAM Gene

mRNA expression in normal human tissues for CERCAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CERCAM Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x7.3), Brain - Putamen (basal ganglia) (x5.0), Brain - Substantia nigra (x4.7), and Brain - Hippocampus (x4.5).

Protein differential expression in normal tissues from HIPED for CERCAM Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CERCAM Gene



SOURCE GeneReport for Unigene cluster for CERCAM Gene Hs.495230

mRNA Expression by UniProt/SwissProt for CERCAM Gene

Q5T4B2-GT253_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in secretory and nervous tissues.
genes like me logo Genes that share expression patterns with CERCAM: view

Protein tissue co-expression partners for CERCAM Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CERCAM Gene

This gene was present in the common ancestor of animals.

Orthologs for CERCAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CERCAM 36
  • 99 (a)
OneToOne
CERCAM 35
  • 99.33 (n)
  • 98.66 (a)
cow
(Bos Taurus)
Mammalia CERCAM 36
  • 91 (a)
OneToOne
CERCAM 35
  • 89.04 (n)
  • 90.72 (a)
dog
(Canis familiaris)
Mammalia CERCAM 35
  • 88.89 (n)
  • 90.85 (a)
CERCAM 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cercam 16
Cercam 35
  • 82.73 (n)
  • 84.11 (a)
Cercam 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CERCAM 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CERCAM 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cercam 35
  • 83.69 (n)
  • 86.27 (a)
chicken
(Gallus gallus)
Aves CERCAM 35
  • 72.15 (n)
  • 71.96 (a)
CERCAM 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
ManyToMany
-- 36
  • 43 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488028 35
  • 63.3 (n)
  • 59.92 (a)
zebrafish
(Danio rerio)
Actinopterygii cercam 36
  • 59 (a)
OneToOne
cercam 35
  • 65.31 (n)
  • 63.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31915 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D2045.9 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for CERCAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CERCAM Gene

ENSEMBL:
Gene Tree for CERCAM (if available)
TreeFam:
Gene Tree for CERCAM (if available)

Paralogs for CERCAM Gene

Paralogs for CERCAM Gene

(4) SIMAP similar genes for CERCAM Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CERCAM: view

Variants for CERCAM Gene

Sequence variations from dbSNP and Humsavar for CERCAM Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs6918 -- 128,437,297(+) CAGAC(A/C)TGTTG utr-variant-3-prime
rs1046307 -- 128,435,840(+) GCAGC(A/C)CCCGC reference, missense
rs2072397 -- 128,434,057(-) TAAAC(A/T)ACCCC intron-variant
rs2072401 -- 128,423,016(+) ATGGA(A/C/G)AACAG intron-variant
rs2270202 -- 128,429,124(-) CAACC(C/T)GTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CERCAM Gene

Variant ID Type Subtype PubMed ID
dgv8294n71 CNV Loss 21882294
dgv8295n71 CNV Loss 21882294
nsv893898 CNV Loss 21882294
dgv1378e199 CNV Deletion 23128226

Variation tolerance for CERCAM Gene

Residual Variation Intolerance Score: 84.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CERCAM Gene

HapMap Linkage Disequilibrium report
CERCAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CERCAM Gene

Disorders for CERCAM Gene

Relevant External Links for CERCAM

Genetic Association Database (GAD)
CERCAM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CERCAM

No disorders were found for CERCAM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CERCAM Gene

Publications for CERCAM Gene

  1. Cerebral cell adhesion molecule: a novel leukocyte adhesion determinant on blood-brain barrier capillary endothelium. (PMID: 10608765) Starzyk R.M. … Tuomanen E.I. (J. Infect. Dis. 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3
  5. Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate. (PMID: 23097496) Tyler R.E. … Kopito R.R. (Mol. Biol. Cell 2012) 3

Products for CERCAM Gene

Sources for CERCAM Gene

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