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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CER1 Gene

protein-coding   GIFtS: 54
GCID: GC09M014710

cerberus 1, DAN family BMP antagonist

(Previous names: cerberus 1 (Xenopus laevis) homolog (cysteine knot superfamily),...)
 Explore 2 diseases affiliated with
CER1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CER1    

Aliases
for CER1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cerberus 1, DAN Family BMP Antagonist1 2     Cerberus 1, Cysteine Knot Superfamily, Homolog (Xenopus Laevis)1
DAND41 2 3     Cerberus1
Cerberus-Related Protein2 3     Cerberus 1, Cysteine Knot Superfamily, Homolog2
DAN Domain Family Member 42 3     Cerberus-Related 12
Cerberus 1 (Xenopus Laevis) Homolog (Cysteine Knot Superfamily)1     

External Ids:    HGNC: 18621   Entrez Gene: 93502   Ensembl: ENSG000001478697   OMIM: 6037775   UniProtKB: O958133   

Export aliases for CER1 gene to outside databases

Previous GC identifers: GC09M014885 GC09M014701


Summaries
for CER1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CER1:
This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a
cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone
morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CER1_HUMAN, O95813
Function: Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part
through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and
patterning of the primitive streak (By similarity)

Gene Wiki entry for CER1 (Cerberus)


Genomic Views
for CER1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CER1 gene promoter:
         NF-1   NF-1/L   Tal-1   HNF-3beta   Gfi-1   E47   FOXL1   AREB6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CER1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CER1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CER1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p23-p22   Ensembl cytogenetic band:  9p22.3   HGNC cytogenetic band: 9p23-p22

CER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CER1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M014710:  view genomic region     (about GC identifiers)

Start:
 14,719,722 bp from pter      End:
 14,722,715 bp from pter
Size:
 2,994 bases      Orientation:
 minus strand

Proteins
for CER1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CER1_HUMAN, O95813 (See protein sequence)
Recommended Name: Cerberus precursor  
Size: 267 amino acids; 30084 Da
Subunit: Forms monomers and predominantly dimers (By similarity)
Subcellular location: Secreted (Probable)
Sequence caution: Sequence=AAH69503.1; Type=Erroneous termination; Positions=266; Note=Translated as Ser;
Secondary accessions: Q6ISJ1 Q6ISJ6 Q6ISQ2 Q6ISS1

Explore the universe of human proteins at neXtProt for CER1: NX_O95813

Post-translational modifications:

  • N-glycosylated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95813

    • CER1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005445.1  
    ENSEMBL proteins: 
     ENSP00000370297  
    Reactome Protein details: O95813
    Human Recombinant Protein Products: 
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    Novus Biologicals CER1 Proteins
    Novus Biologicals CER1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space ISS--


    CER1 for ontologies           About GeneDecksing



    CER1 Antibody Products: 
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    ThermoFisher Antibodies for CER1

    Assay Products for CER1: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for CER1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CER1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006207 Cys_knot_C
     IPR016860 Cerberus
     IPR004133 DAN

    Graphical View of Domain Structure for InterPro Entry O95813

    ProtoNet protein and cluster: O95813

    UniProtKB/Swiss-Prot: CER1_HUMAN, O95813
    Similarity: Belongs to the DAN family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain


    Function
    for CER1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CER1_HUMAN, O95813
    Function: Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part
    through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and
    patterning of the primitive streak (By similarity)

         Genatlas biochemistry entry for CER1:
    cerberus related cytokine 1,potentially involved in anterior neural induction and somite formation during mouse
    development,bone morphogenetic protein antagonist

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CER1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CER1:
    hsa-miR-19b-1* hsa-miR-19b-2* hsa-miR-19a* hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmid: CER1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CER1 (see all 7)
    OriGene shRNA RFP: CER1
    OriGene siRNA: CER1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CER1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CER1

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CER1 

    Cell Line
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    Search LifeMap BioReagents cell lines for CER1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CER1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ----
    GO:0005125cytokine activity IEA--
    GO:0016015morphogen activity IDA9660951
    GO:0036122BMP binding IDA9660951
    GO:0042803protein homodimerization activity ISS--


    CER1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for CER1: Cer1tm1Belo Cer1tm1Dgen
         11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Cer1):
     behavior/neurological  cardiovascular system  craniofacial  embryogenesis  growth/size 
     limbs/digits/tail  mortality/aging  nervous system  no phenotypic analysis  normal 
     skeleton 

    CER1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CER1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1PEDF Induced Signaling
    		PEDF Induced Signaling1.00
    		all-trans-Retinoic Acid Signaling in Brain0.59
    		MIF Mediated Glucocorticoid Regulation0.73
    		RAR-Gamma-RXR-Alpha Degradation0.54
    		MIF Regulation of Innate Immune Cells0.71
    		STAT3 Pathway0.47
    		IL-6 Pathway0.61
    		Endothelin-1 Signaling Pathway0.44
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    		ERK Signaling0.61
    3Signaling by BMP
    		Signaling by BMP1.00
    		BMP receptor signaling0.31
    4Signaling by NODAL
    		Signaling by NODAL1.00
    		Regulation of Signaling by NODAL0.56
    5PAK Pathway
    		PAK Pathway1.00
    		Antioxidant Action of Vitamin-C0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CER1 (see all 17)
        Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C
    Rho Family GTPases
    MIF Mediated Glucocorticoid Regulation

    1 BioSystems Pathway for CER1 
        BMP receptor signaling

    5        Reactome Pathways for CER1
        Developmental Biology
    Signal Transduction
    Signaling by NODAL
    Regulation of Signaling by NODAL
    Signaling by BMP


    1         Kegg Pathway  (Kegg details for CER1):
        Wnt signaling pathway


    CER1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CER1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for CER1 (ENSP000003702974) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP2ENSP000003681044STRING: ENSP00000368104
    BMP4ENSP000002454514STRING: ENSP00000245451
    BMPR1AENSP000002247644STRING: ENSP00000224764
    BMPR1BENSP000002645684STRING: ENSP00000264568
    BMPR2ENSP000003637084STRING: ENSP00000363708
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001657ureteric bud development ISS--
    GO:0003419growth plate cartilage chondrocyte proliferation ISS19113921
    GO:0007369gastrulation ISS10049596
    GO:0007399nervous system development IMP9660951
    GO:0008285negative regulation of cell proliferation ISS10049596


    CER1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CER1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CER1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CER1
    1 Novoseek chemical compound relationship for CER1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 34.2 4 15254711 (2), 15806314 (1)

    Search CenterWatch for drugs/clinical trials and news about CER1 

    Transcripts
    for CER1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CER1 gene: 
    NM_005454.2  

    Unigene Cluster for CER1:

    Cerberus 1, cysteine knot superfamily, homolog (Xenopus laevis)
    Hs.248204  [show with all ESTs]
    Unigene Representative Sequence: NM_005454
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000380911(uc003zlj.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CER1
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CER1:
    hsa-miR-19b-1* hsa-miR-19b-2* hsa-miR-19a* hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmid: CER1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CER1 (see all 7)
    OriGene shRNA RFP: CER1
    OriGene siRNA: CER1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CER1
    Clone
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    GenScript: all cDNA clones in your preferred vector: CER1 (NM_002001)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CER1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CER1 
    Primer
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    Additional cDNA sequence: 

    AF400435.1 BC069371.1 BC069405.1 BC069491.1 BC069503.1 BC103976.1 BC103977.1 

    1 DOTS entry:

    DT.100734132 

    13 AceView cDNA sequences:

    AF400435 NM_005454 BU071333 BC069503 BU557029 BC069371 CD652441 BC069405 
    BU071563 AA866116 BQ478475 BC069491 BU071467 

    GeneLoc Exon Structure


    Expression
    for CER1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CER1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGGCTCCCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CER1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Primitive StreakAnterior Primitive StreakAnterior Primitive Streak CellsEarly Embryo
    EndodermDefinitive EndodermDefinitive Endoderm CellsEarly Embryo, Endoderm
    HypoblastExtraembryonic EndodermExtraembryonic Endoderm CellsExtraembryonic Tissues, Yolk Sac
    HypoblastExtraembryonic Visceral EndodermAnterior Visceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    HypoblastExtraembryonic Visceral EndodermDistal Visceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    HypoblastHypoblastHypoblast CellsExtraembryonic Tissues
    HypoblastVisceral EndodermVisceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    Primitive StreakNotochordNotochord CellsCartilage
    Primitive StreakPrechordal PlatePrechordal Plate CellsEarly Embryo
    Primitive StreakPrimitive StreakPrimitive Streak CellsEarly Embryo
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Definitive endoderm-like cells (Generation and expan...)
    Definitive endoderm-like cells (Generation of mesend...)
    Mesendoderm-like cells (Generation of mesend...)
    Definitive Endoderm (Generation of beta c...)
    Primitive streak-like cells (Generation of endode...)
    Endoderm-like cells (Functional hepatocyt...)
    Definitive endoderm-like cells (A scalable, suspensi...)

    See CER1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CER1

    SOURCE GeneReport for Unigene cluster: Hs.248204
        SABiosciences Custom PCR Arrays for CER1
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CER1

    Orthologs
    for CER1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CER1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CER11 cerberus 1, cysteine knot superfamily, homolog (Xenopus more 58.81(n)
    50.22(a)    		   395623  NM_204823.1  NP_990154.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CER16
    		 --
    		 34(a)
    		 1 ↔ 1
    		 2(34571527-34574452)
    zebrafish
    (Danio rerio)    		 Actinopterygii dand56
    		 DAN domain family, member 5
    		 22(a)
    		 1 → many
    		 1(52320998-52323243)


    ENSEMBL Gene Tree for CER1 (if available)
    TreeFam Gene Tree for CER1 (if available) 

    Paralogs
    for CER1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CER1 gene
    DAND52  

    CER1 for paralogs           About GeneDecksing



    Genomic Variants
    for CER1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/163 NCBI SNPs in CER1 are shown (see all 163)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1865916561,2
    		--14719302(+) ATTAAC/TATCAC 1 -- ds50010--------
    rs109616821,2
    		C,H,--14719331(+) AGAGAC/TCTGAC 1 -- ds50014Minor allele frequency- T:0.00NS EA 418
    rs1439872691,2
    		--14719342(+) ATTAAA/GTACTT 1 -- ds50010--------
    rs770590421,2
    		F,--14719488(+) TCCTAC/TAAATA 1 -- ds50011Minor allele frequency- T:0.06WA 118
    rs117899681,2
    		C,H--14719555(+) tgcctG/Tcctgc 1 -- ds50012Minor allele frequency- T:0.25NA 4
    rs108102251,2
    		C,A,H--14719559(+) TGCCTT/GCCTTC 1 -- ds50014Minor allele frequency- G:0.00NA CSA 7
    rs1837137431,2
    		--14719589(+) CCTTCC/TTTCCT 1 -- ds50010--------
    rs625343191,2
    		--14719613(+) CCTTCT/CTTCTT 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs625343201,2
    		--14719617(+) CCTTCC/TTTCCT 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs1928129811,2
    		--14719621(+) CTTTCC/TTTCCT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CER1 (14719722 - 14722715 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CER1
         1 CNV: 4615
    Human Gene Mutation Database (HGMD): CER1

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    Disorders / Diseases
    for CER1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CER1 for disorders           About GeneDecksing

    OMIM gene information: 603777    OMIM disorders: --

    2 diseases for CER1:    About MalaCards
    norrie disease    lung cancer

    Human Genome Epidemiology (HuGE) Navigator: CER1 (5 documents)

    Export disorders for CER1 gene to outside databases

    Publications
    for CER1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CER1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with CER1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cerberus related gene CER1 maps to chromosome 9. (PubMed id 10049596)1, 2, 3, 9 Lah M.... Harvey R.P. (1999)
    2. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    5. Novel sequence variations in the CER1 gene are strongl y associated with low bone mineral density and risk of osteoporotic fracture in postmenopausal women. (PubMed id 22543871)1 Koromila T....Kollia P. (2012)
    6. Lung cancer susceptibility model based on age, family history and genetic variants. (PubMed id 19390575)1 Young R.P....Gamble G.D. (2009)
    7. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1 Yerges L.M....Zmuda J.M. (2009)
    8. Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with BMD and fracture in southern Chinese women. (PubMed id 19113921)1 Tang P.L....Song Y.Q. (2009)
    9. A gene-based risk score for lung cancer susceptibilit y in smokers and ex-smokers. (PubMed id 19789190)1 Young R.P....Gamble G.D. (2009)
    10. Clinical and cytogenetic characterization of 13 Dutch patients with deletion 9p syndrome: Delineation of the critical region for a consensus phenotype. (PubMed id 18452192)1 Swinkels M.E....van Ravenswaaij-Arts C.M. (2008)

    External Searches for CER1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CER1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9350 HGNC: 1862 AceView: CER1 Ensembl:ENSG00000147869 euGenes: HUgn9350
    ECgene: CER1 Kegg: 9350 H-InvDB: CER1

    Other Databases showing CER1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CER1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CER1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CER1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CER1 gene:
    Search GeneIP for patents involving CER1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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