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Aliases for CER1 Gene

Aliases for CER1 Gene

  • Cerberus 1, DAN Family BMP Antagonist 2 3 5
  • DAN Domain Family Member 4 3 4
  • Cerberus-Related Protein 3 4
  • DAND4 3 4
  • Cerberus 1 (Xenopus Laevis) Homolog (Cysteine Knot Superfamily) 2
  • Cerberus 1, Cysteine Knot Superfamily, Homolog (Xenopus Laevis) 2
  • Cerberus 1, Cysteine Knot Superfamily, Homolog 3
  • Cerberus-Related 1 3

External Ids for CER1 Gene

Previous GeneCards Identifiers for CER1 Gene

  • GC09M014885
  • GC09M014701

Summaries for CER1 Gene

Entrez Gene Summary for CER1 Gene

  • This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for CER1 Gene

CER1 (Cerberus 1, DAN Family BMP Antagonist) is a Protein Coding gene. Diseases associated with CER1 include Regular Astigmatism and Norrie Disease. Among its related pathways are ERK Signaling and PEDF Induced Signaling. GO annotations related to this gene include protein homodimerization activity and BMP binding. An important paralog of this gene is DAND5.

UniProtKB/Swiss-Prot for CER1 Gene

  • Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).

Gene Wiki entry for CER1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CER1 Gene

Genomics for CER1 Gene

Regulatory Elements for CER1 Gene

Enhancers for CER1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CER1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CER1 Gene

Chromosome:
9
Start:
14,719,724 bp from pter
End:
14,722,717 bp from pter
Size:
2,994 bases
Orientation:
Minus strand

Genomic View for CER1 Gene

Genes around CER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CER1 Gene

Proteins for CER1 Gene

  • Protein details for CER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95813-CER1_HUMAN
    Recommended name:
    Cerberus
    Protein Accession:
    O95813
    Secondary Accessions:
    • Q6ISJ1
    • Q6ISJ6
    • Q6ISQ2
    • Q6ISS1

    Protein attributes for CER1 Gene

    Size:
    267 amino acids
    Molecular mass:
    30084 Da
    Quaternary structure:
    • Forms monomers and predominantly dimers.
    SequenceCaution:
    • Sequence=AAH69503.1; Type=Erroneous termination; Positions=266; Note=Translated as Ser.; Evidence={ECO:0000305};

neXtProt entry for CER1 Gene

Proteomics data for CER1 Gene at MOPED

Post-translational modifications for CER1 Gene

Other Protein References for CER1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for Cer1

No data available for DME Specific Peptides for CER1 Gene

Domains & Families for CER1 Gene

Gene Families for CER1 Gene

Protein Domains for CER1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CER1 Gene

Graphical View of Domain Structure for InterPro Entry

O95813

UniProtKB/Swiss-Prot:

CER1_HUMAN :
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Belongs to the DAN family.
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
Family:
  • Belongs to the DAN family.
genes like me logo Genes that share domains with CER1: view

Function for CER1 Gene

Molecular function for CER1 Gene

GENATLAS Biochemistry:
cerberus related cytokine 1,potentially involved in anterior neural induction and somite formation during mouse development,bone morphogenetic protein antagonist
UniProtKB/Swiss-Prot Function:
Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).

LifeMap Function Summary for CER1 Gene

During embryonic development, CER1 as signaling molecule is secreted from the following cells
It affects the following cells:
genes like me logo Genes that share phenotypes with CER1: view

Animal Models for CER1 Gene

MGI Knock Outs for CER1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CER1 Gene

Localization for CER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CER1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CER1 Gene COMPARTMENTS Subcellular localization image for CER1 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CER1 Gene

Pathways & Interactions for CER1 Gene

genes like me logo Genes that share pathways with CER1: view

Pathways by source for CER1 Gene

Interacting Proteins for CER1 Gene

Gene Ontology (GO) - Biological Process for CER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001657 ureteric bud development ISS --
GO:0003419 growth plate cartilage chondrocyte proliferation IEA,ISS 19113921
GO:0007399 nervous system development IMP 9660951
GO:0008285 negative regulation of cell proliferation IEA,ISS 10049596
GO:0009952 anterior/posterior pattern specification IEA,ISS 10049596
genes like me logo Genes that share ontologies with CER1: view

No data available for SIGNOR curated interactions for CER1 Gene

Drugs & Compounds for CER1 Gene

(1) Drugs for CER1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CER1: view

Transcripts for CER1 Gene

mRNA/cDNA for CER1 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CER1 Gene

Cerberus 1, DAN family BMP antagonist:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CER1 Gene

No ASD Table

Relevant External Links for CER1 Gene

GeneLoc Exon Structure for
CER1
ECgene alternative splicing isoforms for
CER1

Expression for CER1 Gene

mRNA expression in normal human tissues for CER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CER1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x5.9), Brain - Cerebellar Hemisphere (x5.4), and Brain - Cerebellum (x4.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CER1 Gene



SOURCE GeneReport for Unigene cluster for CER1 Gene Hs.248204

genes like me logo Genes that share expression patterns with CER1: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CER1 Gene

Orthologs for CER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CER1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CER1 35
  • 81.27 (n)
  • 75.66 (a)
CER1 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CER1 35
  • 85.27 (n)
  • 81.12 (a)
CER1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cer1 35
  • 75.91 (n)
  • 68.54 (a)
Cer1 16
Cer1 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CER1 35
  • 99.13 (n)
  • 98.13 (a)
CER1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cer1 35
  • 76.55 (n)
  • 67.59 (a)
oppossum
(Monodelphis domestica)
Mammalia CER1 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves CER1 35
  • 62.22 (n)
  • 53.89 (a)
CER1 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CER1 36
  • 37 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dand5 36
  • 20 (a)
OneToMany
Species with no ortholog for CER1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CER1 Gene

ENSEMBL:
Gene Tree for CER1 (if available)
TreeFam:
Gene Tree for CER1 (if available)

Paralogs for CER1 Gene

Paralogs for CER1 Gene

genes like me logo Genes that share paralogs with CER1: view

Variants for CER1 Gene

Sequence variations from dbSNP and Humsavar for CER1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10115703 - 14,722,618(+) GTGCC(A/C/G)TGTGG reference, missense
rs3747532 - 14,722,479(+) TGGTG(A/C/G)CTACA reference, missense
rs7036635 - 14,720,359(+) AACTA(A/C/T)TTTTT reference, missense
rs1494357 -- 14,722,153(-) TTCTG(C/G/T)GGGGA intron-variant
rs1494358 -- 14,721,974(-) GCATT(C/G)TGGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CER1 Gene

Variant ID Type Subtype PubMed ID
nsv831517 CNV Loss 17160897
nsv6483 CNV Insertion 18451855
nsv892614 CNV Gain 21882294

Variation tolerance for CER1 Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CER1 Gene

Human Gene Mutation Database (HGMD)
CER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CER1 Gene

Disorders for CER1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CER1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
regular astigmatism
norrie disease
  • anderson-warburg syndrome
osteoporotic fracture
  • osteoporotic fractures
- elite association - COSMIC cancer census association via MalaCards
Search CER1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CER1

Genetic Association Database (GAD)
CER1
Human Genome Epidemiology (HuGE) Navigator
CER1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CER1
genes like me logo Genes that share disorders with CER1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CER1 Gene

Publications for CER1 Gene

  1. Human cerberus related gene CER1 maps to chromosome 9. (PMID: 10049596) Lah M. … Harvey R.P. (Genomics 1999) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Secreted cerberus1 as a marker for quantification of definitive endoderm differentiation of the pluripotent stem cells. (PMID: 23717584) Iwashita H. … Kume S. (PLoS ONE 2013) 3
  4. CER1 gene variations associated with bone mineral density, bone markers, and early menopause in postmenopausal women. (PMID: 24138842) Koromila T. … Kollia P. (Hum. Genomics 2013) 3
  5. Novel sequence variations in the CER1 gene are strongly associated with low bone mineral density and risk of osteoporotic fracture in postmenopausal women. (PMID: 22543871) Koromila T. … Kollia P. (Calcif. Tissue Int. 2012) 3

Products for CER1 Gene

Sources for CER1 Gene

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