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Aliases for CEP97 Gene

Aliases for CEP97 Gene

  • Centrosomal Protein 97kDa 2 3
  • Leucine-Rich Repeat And IQ Domain-Containing Protein 2 3 4
  • Leucine-Rich Repeats And IQ Motif Containing 2 2 3
  • LRRIQ2 3 4
  • Centrosomal Protein Of 97 KDa 3
  • 2810403B08Rik 3
  • Cep97 4

External Ids for CEP97 Gene

Previous Symbols for CEP97 Gene

  • LRRIQ2

Summaries for CEP97 Gene

GeneCards Summary for CEP97 Gene

CEP97 (Centrosomal Protein 97kDa) is a Protein Coding gene. GO annotations related to this gene include calmodulin binding.

UniProtKB/Swiss-Prot for CEP97 Gene

  • Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.

Gene Wiki entry for CEP97 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP97 Gene

Genomics for CEP97 Gene

Genomic Location for CEP97 Gene

Start:
101,723,925 bp from pter
End:
101,770,562 bp from pter
Size:
46,638 bases
Orientation:
Plus strand

Genomic View for CEP97 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP97 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP97 Gene

Regulatory Elements for CEP97 Gene

Proteins for CEP97 Gene

  • Protein details for CEP97 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW35-CEP97_HUMAN
    Recommended name:
    Centrosomal protein of 97 kDa
    Protein Accession:
    Q8IW35
    Secondary Accessions:
    • B5MDY8
    • Q8NA71
    • Q9H5T9

    Protein attributes for CEP97 Gene

    Size:
    865 amino acids
    Molecular mass:
    96981 Da
    Quaternary structure:
    • Interacts with CALM1, CEP76 and CCP110. Via its interaction with CCP110, may indirectly interact with HERC2 and NEURL4. Interacts with KIF24.
    SequenceCaution:
    • Sequence=BAB15531.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04055.1; Type=Frameshift; Positions=303; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP97 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP97 Gene

Proteomics data for CEP97 Gene at MOPED

Post-translational modifications for CEP97 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CEP97 Gene

No data available for DME Specific Peptides for CEP97 Gene

Domains for CEP97 Gene

Protein Domains for CEP97 Gene

Suggested Antigen Peptide Sequences for CEP97 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IW35

UniProtKB/Swiss-Prot:

CEP97_HUMAN
Domain:
  • Contains 1 IQ domain.:
    • Q8IW35
  • Contains 1 LRRCT domain.:
    • Q8IW35
Similarity:
  • Contains 8 LRR (leucine-rich) repeats.:
    • Q8IW35
genes like me logo Genes that share domains with CEP97: view

No data available for Gene Families for CEP97 Gene

Function for CEP97 Gene

Molecular function for CEP97 Gene

UniProtKB/Swiss-Prot Function: Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.

Gene Ontology (GO) - Molecular Function for CEP97 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17719545
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with CEP97: view

miRNA for CEP97 Gene

miRTarBase miRNAs that target CEP97

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEP97 Gene

Localization for CEP97 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP97 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP97 Gene COMPARTMENTS Subcellular localization image for CEP97 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CEP97 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol TAS --
GO:0043234 protein complex IDA 24421332
genes like me logo Genes that share ontologies with CEP97: view

Pathways for CEP97 Gene

SuperPathways for CEP97 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP97 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with CEP97: view

No data available for Pathways by source for CEP97 Gene

Transcripts for CEP97 Gene

Unigene Clusters for CEP97 Gene

Centrosomal protein 97kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP97 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - -

Relevant External Links for CEP97 Gene

GeneLoc Exon Structure for
CEP97
ECgene alternative splicing isoforms for
CEP97

Expression for CEP97 Gene

mRNA expression in normal human tissues for CEP97 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP97 Gene

SOURCE GeneReport for Unigene cluster for CEP97 Gene Hs.444135

genes like me logo Genes that share expressions with CEP97: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP97 Gene

Orthologs for CEP97 Gene

This gene was present in the common ancestor of animals.

Orthologs for CEP97 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP97 35
  • 99.69 (n)
  • 99.65 (a)
CEP97 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEP97 35
  • 87.56 (n)
  • 85.36 (a)
CEP97 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP97 35
  • 89.62 (n)
  • 88.25 (a)
CEP97 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep97 35
  • 80.67 (n)
  • 77.7 (a)
Cep97 16
Cep97 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEP97 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP97 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep97 35
  • 81.48 (n)
  • 79.27 (a)
chicken
(Gallus gallus)
Aves CEP97 35
  • 65.6 (n)
  • 60.17 (a)
CEP97 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP97 36
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7406 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cep97 35
  • 62.42 (n)
  • 59.76 (a)
Str.20324 35
zebrafish
(Danio rerio)
Actinopterygii cep97 35
  • 56.31 (n)
  • 55.18 (a)
cep97 36
  • 44 (a)
OneToOne
zgc63856 35
fruit fly
(Drosophila melanogaster)
Insecta Cep97 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R02F11.4 36
  • 20 (a)
OneToOne
Species with no ortholog for CEP97:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CEP97 Gene

ENSEMBL:
Gene Tree for CEP97 (if available)
TreeFam:
Gene Tree for CEP97 (if available)

Paralogs for CEP97 Gene

No data available for Paralogs for CEP97 Gene

Variants for CEP97 Gene

Sequence variations from dbSNP and Humsavar for CEP97 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1031710 -- 101,745,051(+) TTAAG(C/T)GTACC intron-variant
rs2318090 -- 101,756,089(+) ATAAT(A/G)TCACT intron-variant
rs2449494 -- 101,753,990(-) atgca(A/G)aaaat intron-variant
rs2466364 -- 101,754,243(-) agatc(C/G)gcttc intron-variant
rs2466365 -- 101,753,987(-) cagaa(A/G)atggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP97 Gene

Variant ID Type Subtype PubMed ID
esv2350180 CNV Deletion 18987734
esv2725708 CNV Deletion 23290073
esv2725709 CNV Deletion 23290073

Relevant External Links for CEP97 Gene

HapMap Linkage Disequilibrium report
CEP97

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP97 Gene

Disorders for CEP97 Gene

No disorders were found for CEP97 Gene.

No data available for UniProtKB/Swiss-Prot for CEP97 Gene

Publications for CEP97 Gene

  1. Cep97 and CP110 suppress a cilia assembly program. (PMID: 17719545) Spektor A. … Dynlacht B.D. (Cell 2007) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Double life of centrioles: CP110 in the spotlight. (PMID: 18068367) Bettencourt-Dias M. … Carvalho-Santos Z. (Trends Cell Biol. 2008) 2 3
  5. Cep76, a centrosomal protein that specifically restrains centriole reduplication. (PMID: 19460342) Tsang W.Y. … Dynlacht B.D. (Dev. Cell 2009) 3 4

Products for CEP97 Gene

Sources for CEP97 Gene

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