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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEP97 Gene

protein-coding   GIFtS: 44
GCID: GC03P101442

centrosomal protein 97kDa

(Previous name: leucine-rich repeats and IQ motif containing 2 )
(Previous symbol: LRRIQ2)
  Search for CEP97
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CEP97    

Aliases
for CEP97 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Centrosomal Protein 97kDa1 2     FLJ230471
LRRIQ21 2 3     2810403B08Rik2
Leucine-Rich Repeats And IQ Motif Containing 21 2     Centrosomal Protein Of 97 KDa2
Leucine-Rich Repeat And IQ Domain-Containing Protein 22 3     Cep973

External Ids:    HGNC: 262441   Entrez Gene: 795982   Ensembl: ENSG000001825047   UniProtKB: Q8IW353   

Export aliases for CEP97 gene to outside databases

Previous GC identifers: GC03P102927 GC03P098812


Summaries
for CEP97 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CEP97_HUMAN, Q8IW35
Function: Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole
thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome

Gene Wiki entry for CEP97


Genomic Views
for CEP97 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEP97 gene promoter:
         HTF   CUTL1   STAT5A   POU6F1 (c2)   E4BP4   POU3F2   Gfi-1   MEF-2A   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CEP97 promoter sequence
   Search SABiosciences Chromatin IP Primers for CEP97

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP97


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q12.3   Ensembl cytogenetic band:  3q12.3   HGNC cytogenetic band: 3q12.3

CEP97 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP97 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P101442:  view genomic region     (about GC identifiers)

Start:
 101,442,769 bp from pter      End:
 101,489,406 bp from pter
Size:
 46,638 bases      Orientation:
 plus strand

Proteins
for CEP97 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CEP97_HUMAN, Q8IW35 (See protein sequence)
Recommended Name: Centrosomal protein of 97 kDa  
Size: 865 amino acids; 96981 Da
Subunit: Interacts with CALM1, CEP76 and CCP110. Via its interaction with CCP110, may indirectly interact with HERC2
and NEURL4. Interacts with KIF24
Subcellular location: Cytoplasm, cytoskeleton, centrosome
Sequence caution: Sequence=BAB15531.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAC04055.1; Type=Frameshift; Positions=303;
Secondary accessions: B5MDY8 Q8NA71 Q9H5T9
Alternative splicing: 2 isoforms:  Q8IW35-1   Q8IW35-2   (No experimental confirmation available. Sequence incomplete)

Explore the universe of human proteins at neXtProt for CEP97: NX_Q8IW35

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IW35

    • CEP97 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_078824.2  
    ENSEMBL proteins: 
     ENSP00000342510   ENSP00000418185   ENSP00000419009   ENSP00000418547   ENSP00000325881  

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    Novus Biologicals CEP97 Protein
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    Uscn Proteins for CEP97

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--


    CEP97 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CEP97

    Protein Domains /
    Families
    for CEP97 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CEP97 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR000048 IQ_motif_EF-hand-BS

    Graphical View of Domain Structure for InterPro Entry Q8IW35

    ProtoNet protein and cluster: Q8IW35

    UniProtKB/Swiss-Prot: CEP97_HUMAN, Q8IW35
    Similarity: Contains 1 IQ domain
    Similarity: Contains 8 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain


    Function
    for CEP97 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CEP97_HUMAN, Q8IW35
    Function: Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole
    thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome

    miRNA
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    hsa-miR-142-5p hsa-miR-106a hsa-miR-29c hsa-miR-29a hsa-miR-1271 hsa-miR-519a hsa-miR-410 hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmid: CEP97 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005516calmodulin binding IEA--


    CEP97 for ontologies           About GeneDecksing



    Pathways & Interactions
    for CEP97 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CEP97

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/11 Interacting proteins for CEP97 (Q8IW351, 2, 3 ENSP000003425104) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCP110O433031, 2, 3EBI-2560935,EBI-1566217 MINT-8396999 MINT-8396578 MINT-8396594 MINT-8396494 MINT-8396609 I2D: score=3 
    CEP290O150782, ENSP000003080214MINT-8396578 MINT-8396594 MINT-8396494 MINT-8396609 STRING: ENSP00000308021
    CEP76Q8TAP62, ENSP000002621274MINT-8396578 MINT-8396594 MINT-8396494 MINT-8396609 STRING: ENSP00000262127
    CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
    NEURL4Q96JN82MINT-8396999 MINT-8396578 MINT-8396594 MINT-8396494
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030030cell projection organization IEA--


    CEP97 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CEP97 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEP97
    Search CenterWatch for drugs/clinical trials and news about CEP97 

    Transcripts
    for CEP97 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CEP97 gene: 
    NM_024548.2  

    Unigene Cluster for CEP97:

    Centrosomal protein 97kDa
    Hs.444135  [show with all ESTs]
    Unigene Representative Sequence: AL833269
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341893(uc003dvk.1) ENST00000489172(uc010hpm.1) ENST00000494050
    ENST00000465011 ENST00000467655 ENST00000462076 ENST00000327230(uc011bhf.1 uc003dvl.1 uc003dvm.1)


    miRNA
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    hsa-miR-142-5p hsa-miR-106a hsa-miR-29c hsa-miR-29a hsa-miR-1271 hsa-miR-519a hsa-miR-410 hsa-miR-3167
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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    AK026700.1 AK093100.1 AK225573.1 AK294784.1 AK309806.1 AL833269.1 BC041085.1 

    5 DOTS entries:

    DT.305045  DT.100026981  DT.100026979  DT.101985994  DT.120924216 

    24/72 AceView cDNA sequences (see all 72):

    AX747922 AK093100 AA911641 AW169839 AL602237 F08229 R02513 CR605625 
    AI078202 BM449694 NM_024548 AL598664 BC041085 BU179261 AK026700 BU629992 
    BI093308 AL559474 AI890385 AA970461 BX280346 AL703387 BX095457 AW273802 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CEP97    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                                          -               
    SP2:                          -                       -                                       


    ECgene alternative splicing isoforms for CEP97

    Expression
    for CEP97 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEP97 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CEP97 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CEP97 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CEP97

    SOURCE GeneReport for Unigene cluster: Hs.444135
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    In Situ
    Assay Products:     
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    Orthologs
    for CEP97 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CEP97 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cep971 , 5 centrosomal protein 971, 5 80.67(n)1
    77.7(a)1    		   16 (33.69 cM)5
    742011  NM_028815.41  NP_083091.11 
     558998885 
    chicken
    (Gallus gallus)    		 Aves CEP971 centrosomal protein 97kDa 65.37(n)
    59.41(a)    		   418402  XM_416617.2  XP_416617.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CEP976
    		 --
    		 56(a)
    		 1 ↔ 1
    		 3(173555298-173575626)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.74062 Xenopus laevis transcribed sequence with weak similarity more 75.82(n)    CA792511.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc638562 zgc63856 74.07(n)   386640  BC053114.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Cep976
    		 --
    		 24(a)
    		 1 ↔ 1
    		 2L(3867714-3871425)
    worm
    (Caenorhabditis elegans)    		 Secernentea R02F11.46
    		 Protein R02F11.4
    		 17(a)
    		 1 ↔ 1
    		 V(4810913-4818649)


    ENSEMBL Gene Tree for CEP97 (if available)
    TreeFam Gene Tree for CEP97 (if available) 

    Paralogs
    for CEP97 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for CEP97 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/43 NCBI SNPs in CEP97 are shown (see all 43)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1833501091,2
    		--101441869(+) TAAATA/CTATAA 1 -- us2k10--------
    rs1872496771,2
    		--101441893(+) TAATAC/TATAAA 1 -- us2k10--------
    rs76288661,2
    		C,A,H,--101441900(+) TAAATA/CTATAA 1 -- us2k12Minor allele frequency- C:0.34NA 122
    rs1931872031,2
    		--101441903(+) ATATAC/TAACAT 1 -- us2k10--------
    rs76312891,2
    		A--101441980(+) atataC/Taatat 1 -- us2k10--------
    rs1846545311,2
    		--101441985(+) TAATAC/TATATA 1 -- us2k10--------
    rs124921021,2
    		C,H,--101442026(+) taacaC/Tatata 1 -- us2k12Minor allele frequency- T:0.00NA 4
    rs1922766661,2
    		--101442050(+) TAACAC/TATATA 1 -- us2k10--------
    rs1836371511,2
    		--101442145(+) AATATA/CTAAAT 1 -- us2k10--------
    rs1883724401,2
    		--101442176(+) AATATA/CTAAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CEP97 (101442769 - 101489406 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CEP97: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP97
    DNA2.0 Custom Variant and Variant Library Synthesis for CEP97

    Disorders / Diseases
    for CEP97 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for CEP97 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEP97 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with CEP97)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cep97 and CP110 suppress a cilia assembly program. (PubMed id 17719545)1, 2, 3 Spektor A.... Dynlacht B.D. (2007)
    2. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PubMed id 22261722)1, 2 Al-Hakim A.K....Pelletier L. (2012)
    3. Cep76, a centrosomal protein that specifically restrains centriole reduplication. (PubMed id 19460342)1, 2 Tsang W.Y.... Dynlacht B.D. (2009)
    4. Double life of centrioles: CP110 in the spotlight. (PubMed id 18068367)1, 3 Bettencourt-Dias M. and Carvalho-Santos Z. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Neurl4, a novel daughter centriole protein, prevents f ormation of ectopic microtubule organizing centres. (PubMed id 22441691)1 Li J....Dynlacht B.D. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Centriolar kinesin Kif24 interacts with CP110 to remo del microtubules and regulate ciliogenesis. (PubMed id 21620453)2 Kobayashi T....Dynlacht B.D. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for CEP97 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CEP97 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79598 HGNC: 26244 AceView: LRRIQ2 Ensembl:ENSG00000182504 euGenes: HUgn79598
    ECgene: CEP97 H-InvDB: CEP97

    Other Databases showing CEP97 gene

    (According to HUGE)
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    Specialized Databases showing CEP97 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CEP97 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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