Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CEP97 Gene

Aliases for CEP97 Gene

  • Centrosomal Protein 97kDa 2 3
  • Leucine-Rich Repeat And IQ Domain-Containing Protein 2 3 4
  • Leucine-Rich Repeats And IQ Motif Containing 2 2 3
  • LRRIQ2 3 4
  • 2810403B08Rik 3
  • Cep97 4

External Ids for CEP97 Gene

Previous HGNC Symbols for CEP97 Gene

  • LRRIQ2

Previous GeneCards Identifiers for CEP97 Gene

  • GC03P102927
  • GC03P101442
  • GC03P098812

Summaries for CEP97 Gene

GeneCards Summary for CEP97 Gene

CEP97 (Centrosomal Protein 97kDa) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include calmodulin binding.

UniProtKB/Swiss-Prot for CEP97 Gene

  • Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.

Gene Wiki entry for CEP97 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP97 Gene

Genomics for CEP97 Gene

Regulatory Elements for CEP97 Gene

Genomic Location for CEP97 Gene

Chromosome:
3
Start:
101,723,925 bp from pter
End:
101,770,562 bp from pter
Size:
46,638 bases
Orientation:
Plus strand

Genomic View for CEP97 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP97 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP97 Gene

Proteins for CEP97 Gene

  • Protein details for CEP97 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW35-CEP97_HUMAN
    Recommended name:
    Centrosomal protein of 97 kDa
    Protein Accession:
    Q8IW35
    Secondary Accessions:
    • B5MDY8
    • Q8NA71
    • Q9H5T9

    Protein attributes for CEP97 Gene

    Size:
    865 amino acids
    Molecular mass:
    96981 Da
    Quaternary structure:
    • Interacts with CALM1, CEP76 and CCP110. Via its interaction with CCP110, may indirectly interact with HERC2 and NEURL4. Interacts with KIF24.
    SequenceCaution:
    • Sequence=BAB15531.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04055.1; Type=Frameshift; Positions=303; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP97 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP97 Gene

Proteomics data for CEP97 Gene at MOPED

Post-translational modifications for CEP97 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CEP97 Gene

Antibody Products

No data available for DME Specific Peptides for CEP97 Gene

Domains & Families for CEP97 Gene

Protein Domains for CEP97 Gene

Suggested Antigen Peptide Sequences for CEP97 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IW35

UniProtKB/Swiss-Prot:

CEP97_HUMAN :
  • Contains 1 IQ domain.
  • Contains 8 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 IQ domain.
  • Contains 1 LRRCT domain.
Similarity:
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with CEP97: view

No data available for Gene Families for CEP97 Gene

Function for CEP97 Gene

Molecular function for CEP97 Gene

UniProtKB/Swiss-Prot Function:
Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.

Gene Ontology (GO) - Molecular Function for CEP97 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17719545
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with CEP97: view

Phenotypes for CEP97 Gene

GenomeRNAi human phenotypes for CEP97:
genes like me logo Genes that share phenotypes with CEP97: view

Animal Model Products

miRNA for CEP97 Gene

miRTarBase miRNAs that target CEP97

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP97

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP97 Gene

Localization for CEP97 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP97 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP97 Gene COMPARTMENTS Subcellular localization image for CEP97 gene
Compartment Confidence
cytoskeleton 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CEP97 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol TAS --
GO:0043234 protein complex IDA 24421332
genes like me logo Genes that share ontologies with CEP97: view

Pathways & Interactions for CEP97 Gene

genes like me logo Genes that share pathways with CEP97: view

Gene Ontology (GO) - Biological Process for CEP97 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with CEP97: view

No data available for SIGNOR curated interactions for CEP97 Gene

Drugs & Compounds for CEP97 Gene

No Compound Related Data Available

Transcripts for CEP97 Gene

Unigene Clusters for CEP97 Gene

Centrosomal protein 97kDa:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP97

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP97 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - -

Relevant External Links for CEP97 Gene

GeneLoc Exon Structure for
CEP97
ECgene alternative splicing isoforms for
CEP97

Expression for CEP97 Gene

mRNA expression in normal human tissues for CEP97 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEP97 Gene

This gene is overexpressed in Heart (49.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP97 Gene



SOURCE GeneReport for Unigene cluster for CEP97 Gene Hs.444135

genes like me logo Genes that share expression patterns with CEP97: view

Protein tissue co-expression partners for CEP97 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP97 Gene

Orthologs for CEP97 Gene

This gene was present in the common ancestor of animals.

Orthologs for CEP97 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEP97 35
  • 87.56 (n)
  • 85.36 (a)
CEP97 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP97 35
  • 89.62 (n)
  • 88.25 (a)
CEP97 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep97 35
  • 80.67 (n)
  • 77.7 (a)
Cep97 16
Cep97 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CEP97 35
  • 99.69 (n)
  • 99.65 (a)
CEP97 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep97 35
  • 81.48 (n)
  • 79.27 (a)
oppossum
(Monodelphis domestica)
Mammalia CEP97 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP97 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP97 35
  • 65.6 (n)
  • 60.17 (a)
CEP97 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP97 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep97 35
  • 62.42 (n)
  • 59.76 (a)
Str.20324 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7406 35
zebrafish
(Danio rerio)
Actinopterygii cep97 35
  • 56.31 (n)
  • 55.18 (a)
zgc63856 35
cep97 36
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cep97 36
  • 27 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R02F11.4 36
  • 20 (a)
OneToOne
Species with no ortholog for CEP97:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CEP97 Gene

ENSEMBL:
Gene Tree for CEP97 (if available)
TreeFam:
Gene Tree for CEP97 (if available)

Paralogs for CEP97 Gene

No data available for Paralogs for CEP97 Gene

Variants for CEP97 Gene

Sequence variations from dbSNP and Humsavar for CEP97 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs994573 -- 101,724,617(+) TCAGA(C/T)TACAA utr-variant-5-prime, upstream-variant-2KB
rs1031710 -- 101,745,051(+) TTAAG(C/T)GTACC intron-variant
rs1551691 -- 101,744,800(+) AAAAT(A/T)TTTTC intron-variant
rs1963961 -- 101,744,469(+) ttcca(G/T)ctact intron-variant
rs1963962 -- 101,744,547(+) cattg(C/T)actcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP97 Gene

Variant ID Type Subtype PubMed ID
esv2350180 CNV Deletion 18987734
esv2725708 CNV Deletion 23290073
esv2725709 CNV Deletion 23290073

Variation tolerance for CEP97 Gene

Residual Variation Intolerance Score: 59.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP97 Gene

HapMap Linkage Disequilibrium report
CEP97

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP97 Gene

Disorders for CEP97 Gene

Relevant External Links for CEP97

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP97
genes like me logo Genes that share disorders with CEP97: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP97 Gene

Publications for CEP97 Gene

  1. Double life of centrioles: CP110 in the spotlight. (PMID: 18068367) Bettencourt-Dias M. … Carvalho-Santos Z. (Trends Cell Biol. 2008) 2 67
  2. Cep97 and CP110 suppress a cilia assembly program. (PMID: 17719545) Spektor A. … Dynlacht B.D. (Cell 2007) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 67

Products for CEP97 Gene

Sources for CEP97 Gene

Back to Top

Content