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CEP95 Gene

protein-coding   GIFtS: 38
GCID: GC17P062502

Centrosomal Protein 95kDa

(Previous name: coiled-coil domain containing 45)
(Previous symbol: CCDC45)
  Search for CEP95
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centrosomal Protein 95kDa1 2     Centrosomal Protein Of 95 KDa2
CCDC451 2 3     CEP453
Coiled-Coil Domain Containing 451 2     Cep953
Coiled-Coil Domain-Containing Protein 452 3     

External Ids:    HGNC: 251411   Entrez Gene: 907992   Ensembl: ENSG000002588907   UniProtKB: Q96GE43   

Export aliases for CEP95 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CEP95 Gene:
CEP95 (centrosomal protein 95kDa) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CEP95
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEP95 promoter sequence
   Search Chromatin IP Primers for CEP95

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEP95


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q24.1

CEP95 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP95 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P062502:  view genomic region     (about GC identifiers)

Start:
62,502,706 bp from pter      End:
62,538,579 bp from pter
Size:
35,874 bases      Orientation:
plus strand

1 alternative location:
Chr17+,NW_003315947 310,887-341,793     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CEP95_HUMAN, Q96GE4 (See protein sequence)
Recommended Name: Centrosomal protein of 95 kDa  
Size: 821 amino acids; 95297 Da
Secondary accessions: Q96M81

Explore the universe of human proteins at neXtProt for CEP95: NX_Q96GE4

Explore proteomics data for CEP95 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys320, Lys387, Lys704
  • Modification sites at PhosphoSitePlus

  • See CEP95 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612372.1  
    ENSEMBL proteins: 
     ENSP00000450461   ENSP00000462779   ENSP00000467102   ENSP00000462189   ENSP00000452317  
     ENSP00000463535   ENSP00000462639   ENSP00000461924   ENSP00000462307   ENSP00000450906  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR026619 CEP95
     IPR001715 CH-domain

    Graphical View of Domain Structure for InterPro Entry Q96GE4

    ProtoNet protein and cluster: Q96GE4


    CEP95 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CEP95 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEP95
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    hsa-miR-892b hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidCEP95 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CEP95_HUMAN, Q96GE4: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton,
    spindle pole

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA--
    GO:0005737cytoplasm IEA--
    GO:0005813centrosome IDA--

    CEP95 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CEP95
    Interactions:

        Search GeneGlobe Interaction Network for CEP95

    Selected Interacting proteins for CEP95 (Q96GE43) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LSM3P623103I2D: score=3 
    YWHAEP622583I2D: score=3 
    YWHAGP619813I2D: score=3 
    SEPT2Q150193I2D: score=1 
    WNK1Q9H4A33I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CEP95



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CEP95 gene: 
    NM_138363.1  

    Unigene Cluster for CEP95:

    Centrosomal protein 95kDa
    Hs.569713  [show with all ESTs]
    Unigene Representative Sequence: BX641136
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000556440(uc002jem.3 uc002jen.3) ENST00000579860 ENST00000580188
    ENST00000581056 ENST00000553956 ENST00000582724 ENST00000577960 ENST00000577476
    ENST00000579117 ENST00000583457 ENST00000579478 ENST00000584857 ENST00000579637
    ENST00000582698 ENST00000580285(uc002jeo.1) ENST00000581885 ENST00000583676
    ENST00000581980
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CEP95:
    hsa-miR-892b hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidCEP95 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CEP95
      QuantiFast Probe-based Assays in human, mouse, rat CEP95

    Additional mRNA sequence: 

    AK057326.1 AK290587.1 AK297409.1 AK316257.1 AL832822.1 BC009518.1 BC029461.1 BX641136.1 

    Selected DOTS entries (see all 26):

    DT.92417642  DT.99947863  DT.92052713  DT.91653854  DT.100026448  DT.215419  DT.215417  DT.100712308 
    DT.95234009  DT.40129126  DT.40207436  DT.95149141  DT.91893798  DT.95354954  DT.95366265  DT.97841518 
    DT.120898070  DT.95158387  DT.102839724  DT.65286342  DT.75137073  DT.75184736  DT.91974888  DT.95288839 

    Selected AceView cDNA sequences (see all 172):

    BU620284 AI523715 BU634009 AA385582 CA407856 BX641136 CB135662 BU194663 
    AW196154 BC009518 BU677611 CA314696 AI752846 CB105342 BU521626 NM_138363 
    AV658237 AI291622 AW167096 AI754731 AW337915 AV653950 AI022227 AI625829 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CEP95 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAACACAGA
    CEP95 Expression
    About this image

    CEP95 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEP95 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.569713
        Custom PCR Arrays for CEP95
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP95

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CEP95 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cep951 , 5 coiled-coil domain containing 455
    centrosomal protein 951
    79.85(n)1
    73.96(a)1
      11 (70.02 cM)5
    3201621  NM_177088.31  NP_796062.21 
     1067892755 
    chicken
    (Gallus gallus)
    Aves CEP951 centrosomal protein 95kDa 61.97(n)
    54.12(a)
      417419  XM_415671.4  XP_415671.3 
    lizard
    (Anolis carolinensis)
    Reptilia CEP956
    centrosomal protein 95kDa
    42(a)
    1 ↔ 1
    GL343250.1(1282206-1310372)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD303435.12   -- 73.93(n)    CD303435.1 


    ENSEMBL Gene Tree for CEP95 (if available)
    TreeFam Gene Tree for CEP95 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CEP95 gene
    9 SIMAP similar genes for CEP95 using alignment to 11 protein entries:     CEP95_HUMAN (see all proteins):
    DKFZp667E1824    ACTR10    MST132    DOCK8    RRM1    LSM12
    PFKFB3    SPG7    DYNC2LI1

    CEP95 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CEP95 (see all 614)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2019622901,2
    --62504621(+) TTGTT-/GGGGGG 1 -- int10--------
    rs2009137621,2
    C--62504749(+) GTGTCA/GTATAC 2 H R mis10--------
    rs1876008051,2
    --62504962(+) TTAATA/GTTGCA 1 -- int10--------
    rs1495842791,2
    --62504984(+) ATATTA/GATATA 1 -- int10--------
    rs764185831,2
    F--62504989(+) AATATC/ACAATA 1 -- int11Minor allele frequency- A:0.50NA 4
    rs98944361,2
    C,F--62504990(+) atataC/Taatat 1 -- int11Minor allele frequency- T:0.05WA 118
    rs1928315221,2
    --62505029(+) TTTAAC/TATCAC 1 -- int10--------
    rs1165517501,2
    F--62505034(+) TATCAC/TATATT 1 -- int11Minor allele frequency- T:0.02WA 118
    rs80711241,2
    C,F--62505073(+) GAATAC/GCCTGT 1 -- int11Minor allele frequency- G:0.03WA 118
    rs80711251,2
    C,F,H--62505074(+) AATACC/TCTGTG 1 -- int14Minor allele frequency- T:0.01NS EA 416

    HapMap Linkage Disequilibrium report for CEP95 (62502706 - 62538579 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CEP95:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv828085CNV Loss20364138
    nsv819879CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CEP95
    DNA2.0 Custom Variant and Variant Library Synthesis for CEP95

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CEP95 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with CEP95)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PubMed id 21399614)1, 2, 3 Jakobsen L.... Andersen J.S. (EMBO J. 2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90799 HGNC: 25141 AceView: LOC90799 Ensembl:ENSG00000258890 euGenes: HUgn90799
    ECgene: CEP95 H-InvDB: CEP95

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CEP95 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CEP95 gene:
    Search GeneIP for patents involving CEP95

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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