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Aliases for CEP95 Gene

Aliases for CEP95 Gene

  • Centrosomal Protein 95 2 3
  • Centrosomal Protein 95kDa 2 3 5
  • Coiled-Coil Domain-Containing Protein 45 3 4
  • Coiled-Coil Domain Containing 45 2 3
  • CCDC45 3 4
  • CEP45 4
  • Cep95 4

External Ids for CEP95 Gene

Previous HGNC Symbols for CEP95 Gene

  • CCDC45

Previous GeneCards Identifiers for CEP95 Gene

  • GC17P062502

Summaries for CEP95 Gene

GeneCards Summary for CEP95 Gene

CEP95 (Centrosomal Protein 95) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP95 Gene

Genomics for CEP95 Gene

Regulatory Elements for CEP95 Gene

Promoters for CEP95 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEP95 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEP95 Gene

Chromosome:
17
Start:
64,506,588 bp from pter
End:
64,542,461 bp from pter
Size:
35,874 bases
Orientation:
Plus strand

Genomic View for CEP95 Gene

Genes around CEP95 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP95 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP95 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP95 Gene

Proteins for CEP95 Gene

  • Protein details for CEP95 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GE4-CEP95_HUMAN
    Recommended name:
    Centrosomal protein of 95 kDa
    Protein Accession:
    Q96GE4
    Secondary Accessions:
    • B4DMD2
    • Q96M81

    Protein attributes for CEP95 Gene

    Size:
    821 amino acids
    Molecular mass:
    95297 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CEP95 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP95 Gene

Proteomics data for CEP95 Gene at MOPED

Post-translational modifications for CEP95 Gene

  • Ubiquitination at Lys 320, Lys 387, and Lys 704
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP95 Gene

Domains & Families for CEP95 Gene

Protein Domains for CEP95 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP95 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEP95: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CEP95 Gene

Function for CEP95 Gene

Phenotypes for CEP95 Gene

GenomeRNAi human phenotypes for CEP95:
genes like me logo Genes that share phenotypes with CEP95: view

Animal Model Products

CRISPR Products

miRNA for CEP95 Gene

miRTarBase miRNAs that target CEP95

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP95 Gene

Localization for CEP95 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP95 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP95 Gene COMPARTMENTS Subcellular localization image for CEP95 gene
Compartment Confidence
cytoskeleton 5

Gene Ontology (GO) - Cellular Components for CEP95 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 21399614
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CEP95: view

Pathways & Interactions for CEP95 Gene

SuperPathways for CEP95 Gene

No Data Available

Interacting Proteins for CEP95 Gene

Gene Ontology (GO) - Biological Process for CEP95 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEP95 Gene

Drugs & Compounds for CEP95 Gene

No Compound Related Data Available

Transcripts for CEP95 Gene

Unigene Clusters for CEP95 Gene

Centrosomal protein 95kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP95 Gene

No ASD Table

Relevant External Links for CEP95 Gene

GeneLoc Exon Structure for
CEP95
ECgene alternative splicing isoforms for
CEP95

Expression for CEP95 Gene

mRNA expression in normal human tissues for CEP95 Gene

Protein differential expression in normal tissues from HIPED for CEP95 Gene

This gene is overexpressed in Thyroid (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CEP95 Gene



SOURCE GeneReport for Unigene cluster for CEP95 Gene Hs.569713

genes like me logo Genes that share expression patterns with CEP95: view

Protein tissue co-expression partners for CEP95 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP95 Gene

Orthologs for CEP95 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP95 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP95 35
  • 99.35 (n)
  • 98.78 (a)
CEP95 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEP95 36
  • 83 (a)
OneToOne
CEP95 35
  • 88.41 (n)
  • 83.23 (a)
dog
(Canis familiaris)
Mammalia CEP95 35
  • 87.81 (n)
  • 83 (a)
CEP95 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep95 16
Cep95 35
  • 79.85 (n)
  • 73.96 (a)
Cep95 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEP95 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP95 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep95 35
  • 78.64 (n)
  • 73.09 (a)
chicken
(Gallus gallus)
Aves CEP95 35
  • 61.97 (n)
  • 54.12 (a)
CEP95 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP95 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep95 35
  • 56.76 (n)
  • 50.91 (a)
Str.11457 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
CSA.6755 36
  • 27 (a)
OneToMany
Species with no ortholog for CEP95:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEP95 Gene

ENSEMBL:
Gene Tree for CEP95 (if available)
TreeFam:
Gene Tree for CEP95 (if available)

Paralogs for CEP95 Gene

genes like me logo Genes that share paralogs with CEP95: view

No data available for Paralogs for CEP95 Gene

Variants for CEP95 Gene

Sequence variations from dbSNP and Humsavar for CEP95 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs9910506 - 64,519,342(+) GAGAT(A/G)TTGGG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs11550922 - 64,537,745(-) AGGAA(A/G)CCAGC reference, missense, utr-variant-3-prime
rs4790970 -- 64,530,878(-) CACAA(C/T)GGGCA intron-variant
rs7223680 -- 64,531,587(+) TTAAT(A/G)GTTAA intron-variant
rs9890575 -- 64,511,895(+) cagcc(A/G)gtccc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP95 Gene

Variant ID Type Subtype PubMed ID
nsv819879 CNV Gain 19587683
nsv828085 CNV Loss 20364138

Variation tolerance for CEP95 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP95 Gene

HapMap Linkage Disequilibrium report
CEP95

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP95 Gene

Disorders for CEP95 Gene

Relevant External Links for CEP95

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP95

No disorders were found for CEP95 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP95 Gene

Publications for CEP95 Gene

  1. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L. … Andersen J.S. (EMBO J. 2011) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for CEP95 Gene

Sources for CEP95 Gene

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