CEP95 Gene
protein-coding GIFtS: 36
GCID: GC17P062502
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centrosomal protein 95kDa(Previous name: coiled-coil domain containing 45 )
(Previous symbol: CCDC45)
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Aliases
for CEP95 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Centrosomal Protein 95kDa1 2 | | DKFZp667E18241 | | CCDC451 2 3 | | Centrosomal Protein Of 95 KDa2 | | Coiled-Coil Domain Containing 451 2 | | CEP453 | | Coiled-Coil Domain-Containing Protein 452 3 | | |
Export aliases for CEP95 gene to outside databases |
Summaries
for CEP95 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CEP95 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CEP95
Other transcription factors
Search SABiosciences Chromatin IP Primers for CEP95
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP95 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q23.3 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q24.1CEP95 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P062502: view genomic region
(about GC identifiers)
Start:
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62,502,706 bp from pter |
End:
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62,538,579 bp from pter |
Size:
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35,874 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr17+,PATCHES 62,543,779-62,574,685 |
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Proteins
for CEP95 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CEP95_HUMAN, Q96GE4 (See
protein sequence)Recommended Name: Centrosomal protein of 95 kDa Size: 821 amino acids; 95297 Da
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole
Secondary accessions: Q96M81Explore the universe of human proteins at neXtProt for CEP95: NX_Q96GE4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96GE4
CEP95 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612372.1
ENSEMBL proteins: ENSP00000450461 ENSP00000462779 ENSP00000467102 ENSP00000462189 ENSP00000452317 ENSP00000463535 ENSP00000462639 ENSP00000461924 ENSP00000462307 ENSP00000450906
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CEP95 for ontologies About GeneDecksing
CEP95 Antibody Products:
Assay Products for CEP95: |
Protein
Domains /
Families
for CEP95 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CEP95 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96GE4ProtoNet protein and cluster: Q96GE4 |
Function
for CEP95 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP95 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP95
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for CEP95 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEP95 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP95 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP95 |
|
Pathways & Interactions
for CEP95 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEP95
5/6 Interacting proteins for CEP95 (Q96GE43) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for CEP95 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CEP95
Search CenterWatch for drugs/clinical trials and news about CEP95
|
Transcripts
for CEP95 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CEP95 gene: NM_138363.1 Unigene Cluster for CEP95: Centrosomal protein 95kDa Hs.569713 [show with all ESTs]Unigene Representative Sequence: BX64113618/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19): ENST00000556440(uc002jem.3 uc002jen.3) ENST00000579860 ENST00000580188
ENST00000581056 ENST00000553956 ENST00000582724 ENST00000577960 ENST00000577476
ENST00000579117 ENST00000583457 ENST00000579478 ENST00000584857 ENST00000579637
ENST00000582698 ENST00000580285(uc002jeo.1) ENST00000581885 ENST00000583676
ENST00000581980
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP95 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP95
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CEP95 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEP95 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP95 |
Additional cDNA sequence: AK057326.1 AK290587.1 AK297409.1 AK316257.1 AL832822.1 BC009518.1 BC029461.1 BX641136.1 24/26 DOTS entries (see all 26): DT.92417642 DT.99947863 DT.92052713 DT.91653854 DT.100026448 DT.215419 DT.215417 DT.100712308 DT.95234009 DT.40129126 DT.40207436 DT.95149141 DT.91893798 DT.95354954 DT.95366265 DT.97841518 DT.120898070 DT.95158387 DT.102839724 DT.65286342 DT.75137073 DT.75184736 DT.91974888 DT.95288839 24/172 AceView cDNA sequences (see all 172): AI752846 CA407856 AV658237 AI291608 BU521626 AI291622 AW196154 BU620284 BF000481 BP357015 CB105342 AV653950 AA974645 BX641136 BQ434147 AA284770 AW439670 AI523715 BU677611 CB135662 CA314696 AW574707 AW337915 AI688933
GeneLoc Exon Structure
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Expression
for CEP95 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CEP95 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAACACAGA
About this image
See CEP95 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEP95
SOURCE GeneReport for Unigene cluster: Hs.569713
SABiosciences Custom PCR Arrays for CEP95
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP95
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CEP95 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP95 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP95 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP95 |
Orthologs
for CEP95 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CEP95 gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for CEP95 (if available)
TreeFam Gene Tree for CEP95 (if available) |
Paralogs
for CEP95 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CEP95 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CEP95 (62502706 - 62538579 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CEP95: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for CEP95 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CEP95 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CEP95 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with CEP95) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PubMed id 21399614)1, 2, 3 Jakobsen L.... Andersen J.S. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
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External Searches for CEP95 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CEP95 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CEP95 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CEP95 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CEP95 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CEP95 gene:
Search GeneIP for patents involving CEP95
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CEP95 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEP95 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP95 | | | OriGene Protein Over-expression Lysate for CEP95 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CEP95 | | OriGene 3'-UTR Clone for CEP95 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP95 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP95 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CEP95 | | OriGene Custom Protein Services for CEP95 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CEP95 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP95 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP95 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEP95 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP95 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP95 |
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 |  |  |  | |
| | | | Search Tocris compounds for CEP95 |
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 | | | CEP95 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP95 |
|  |  |  | | | | Search ThermoFisher Antibodies for CEP95 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP95 |
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