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Aliases for CEP95 Gene

Aliases for CEP95 Gene

  • Centrosomal Protein 95 2 3 5
  • Coiled-Coil Domain-Containing Protein 45 3 4
  • Coiled-Coil Domain Containing 45 2 3
  • Centrosomal Protein 95kDa 2 3
  • CCDC45 3 4
  • Centrosomal Protein Of 95 KDa 3
  • CEP45 4
  • Cep95 4

External Ids for CEP95 Gene

Previous HGNC Symbols for CEP95 Gene

  • CCDC45

Previous GeneCards Identifiers for CEP95 Gene

  • GC17P062502

Summaries for CEP95 Gene

GeneCards Summary for CEP95 Gene

CEP95 (Centrosomal Protein 95) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP95 Gene

Genomics for CEP95 Gene

Regulatory Elements for CEP95 Gene

Enhancers for CEP95 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F063760 0.9 Ensembl ENCODE 136.6 -744.8 -744803 1.6 ZNF493 ZFP64 ZNF155 ZNF121 ZNF366 ZNF302 ZNF354C ZNF138 EGR2 PAF1 CEP95 DDX42 POLG2 MIR3064 FTSJ3 PSMC5 LIMD2 SMARCD2 EEF1DP7 GC17P063754
GH17F063837 1 FANTOM5 ENCODE 67.6 -665.6 -665617 7.4 CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 POLG2 CEP95 FTSJ3 DDX42 PLEKHM1P1 MIR3064 ENSG00000265982 MAP3K3 CSH2 EEF1DP7
GH17F063621 0.2 ENCODE 47.1 -884.0 -883989 3.1 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 DDX42 CEP95 MIR3064 POLG2 EEF1DP7 MAP3K3 FTSJ3 GC17M063634
GH17F064607 1 Ensembl 46 +101.1 101113 0.2 ZFP64 ZNF140 ZNF266 ZNF101 ZNF366 ZNF202 SP3 ZNF680 ZBTB11 ZFP37 CEP95 DDX42 SLC16A6P1 POLG2 ENSG00000265218 ENSG00000264057 ENSG00000265912 AMZ2P1 ENSG00000265982 ENSG00000271779
GH17F063681 0.2 ENCODE 42.6 -825.0 -824953 0.2 ZFP64 MAX ZNF266 ZNF101 YY1 ZNF664 CTBP1 FOSL2 FOS ZNF202 CEP95 DDX42 POLG2 MIR3064 LOC101927898 EEF1DP7
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CEP95 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEP95 Gene

Chromosome:
17
Start:
64,506,588 bp from pter
End:
64,542,461 bp from pter
Size:
35,874 bases
Orientation:
Plus strand

Genomic View for CEP95 Gene

Genes around CEP95 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP95 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP95 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP95 Gene

Proteins for CEP95 Gene

  • Protein details for CEP95 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GE4-CEP95_HUMAN
    Recommended name:
    Centrosomal protein of 95 kDa
    Protein Accession:
    Q96GE4
    Secondary Accessions:
    • B4DMD2
    • Q96M81

    Protein attributes for CEP95 Gene

    Size:
    821 amino acids
    Molecular mass:
    95297 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CEP95 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP95 Gene

Post-translational modifications for CEP95 Gene

  • Ubiquitination at Lys 320, Lys 387, and Lys 704
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP95 Gene

Domains & Families for CEP95 Gene

Protein Domains for CEP95 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP95 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEP95: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CEP95 Gene

Function for CEP95 Gene

Gene Ontology (GO) - Molecular Function for CEP95 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CEP95: view

Phenotypes for CEP95 Gene

GenomeRNAi human phenotypes for CEP95:
genes like me logo Genes that share phenotypes with CEP95: view

Animal Model Products

miRNA for CEP95 Gene

miRTarBase miRNAs that target CEP95

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP95 Gene

Localization for CEP95 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP95 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP95 Gene COMPARTMENTS Subcellular localization image for CEP95 gene
Compartment Confidence
cytoskeleton 5

Gene Ontology (GO) - Cellular Components for CEP95 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 21399614
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IEA,IDA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CEP95: view

Pathways & Interactions for CEP95 Gene

SuperPathways for CEP95 Gene

No Data Available

Interacting Proteins for CEP95 Gene

Gene Ontology (GO) - Biological Process for CEP95 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEP95 Gene

Transcripts for CEP95 Gene

Unigene Clusters for CEP95 Gene

Centrosomal protein 95kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP95 Gene

No ASD Table

Relevant External Links for CEP95 Gene

GeneLoc Exon Structure for
CEP95
ECgene alternative splicing isoforms for
CEP95

Expression for CEP95 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEP95 Gene

Protein differential expression in normal tissues from HIPED for CEP95 Gene

This gene is overexpressed in Thyroid (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEP95 Gene



Protein tissue co-expression partners for CEP95 Gene

NURSA nuclear receptor signaling pathways regulating expression of CEP95 Gene:

CEP95

SOURCE GeneReport for Unigene cluster for CEP95 Gene:

Hs.569713
genes like me logo Genes that share expression patterns with CEP95: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP95 Gene

Orthologs for CEP95 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP95 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP95 34 35
  • 99.35 (n)
cow
(Bos Taurus)
Mammalia CEP95 34 35
  • 88.41 (n)
dog
(Canis familiaris)
Mammalia CEP95 34 35
  • 87.81 (n)
mouse
(Mus musculus)
Mammalia Cep95 34 16 35
  • 79.85 (n)
rat
(Rattus norvegicus)
Mammalia Cep95 34
  • 78.64 (n)
oppossum
(Monodelphis domestica)
Mammalia CEP95 35
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP95 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP95 34 35
  • 61.97 (n)
lizard
(Anolis carolinensis)
Reptilia CEP95 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep95 34
  • 56.76 (n)
Str.11457 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToMany
CSA.6755 35
  • 27 (a)
OneToMany
Species where no ortholog for CEP95 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEP95 Gene

ENSEMBL:
Gene Tree for CEP95 (if available)
TreeFam:
Gene Tree for CEP95 (if available)

Paralogs for CEP95 Gene

genes like me logo Genes that share paralogs with CEP95: view

No data available for Paralogs for CEP95 Gene

Variants for CEP95 Gene

Sequence variations from dbSNP and Humsavar for CEP95 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10627486 -- 64,514,991(+) CCTCC(-/TTC)ATTCT intron-variant
rs10682250 -- 64,504,992(+) AAATC(-/TCTCCT)TCTCT intron-variant, upstream-variant-2KB
rs10700816 -- 64,504,996(+) CTCTC(-/CTTCTC)AACAG intron-variant, upstream-variant-2KB
rs111291434 -- 64,522,552(+) TCCCT(A/G)GTTTA intron-variant
rs111384226 -- 64,520,183(+) AGAAA(C/T)GGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP95 Gene

Variant ID Type Subtype PubMed ID
nsv1066765 CNV gain 25217958
nsv819879 CNV gain 19587683
nsv828085 CNV loss 20364138

Variation tolerance for CEP95 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP95 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP95

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP95 Gene

Disorders for CEP95 Gene

Relevant External Links for CEP95

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP95

No disorders were found for CEP95 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP95 Gene

Publications for CEP95 Gene

  1. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L. … Andersen J.S. (EMBO J. 2011) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CEP95 Gene

Sources for CEP95 Gene

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