CEP89 Gene
protein-coding GIFtS: 41
GCID: GC19M033370
|
|
centrosomal protein 89kDa(Previous name: coiled-coil domain containing 123 )
(Previous symbol: CCDC123)
| |
Aliases
for CEP89 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Centrosomal Protein 89kDa1 2 | | Centrosomal Protein Of 89 KDa2 | | CCDC1231 2 3 | | Coiled-Coil Domain-Containing Protein 123, Mitochondrial2 | | Coiled-Coil Domain Containing 1231 2 | | Coiled-Coil Domain-Containing Protein 1233 | | FLJ146401 | | |
Export aliases for CEP89 gene to outside databases |
Summaries
for CEP89 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CEP89 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CEP89
Other transcription factors
Search SABiosciences Chromatin IP Primers for CEP89
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP89 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.11 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.11CEP89 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M033370: view genomic region
(about GC identifiers)
Start:
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33,369,904 bp from pter |
End:
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33,462,897 bp from pter |
Size:
|
92,994 bases |
Orientation:
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minus strand |
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Proteins
for CEP89 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CEP89_HUMAN, Q96ST8 (See
protein sequence)Recommended Name: Centrosomal protein of 89 kDa Size: 783 amino acids; 89590 Da
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Note=Localizes tostructures around centrosomes similar to centrosome satellites
Secondary accessions: B9EGA6 Q8N5J8Alternative splicing: 3 isoforms: Q96ST8-1 Q96ST8-2 Q96ST8-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CEP89: NX_Q96ST8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96ST8
CEP89 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116205.3
ENSEMBL proteins: ENSP00000306105 ENSP00000467544 ENSP00000465141 ENSP00000466442 ENSP00000467839
Human Recombinant Protein Products for CEP89:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CEP89 for ontologies About GeneDecksing
CEP89 Antibody Products:
Assay Products for CEP89: |
Protein
Domains /
Families
for CEP89 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96ST8 |
Function
for CEP89 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
CEP89 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP89 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP89 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for CEP89 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEP89 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP89 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP89 |
|
Pathways & Interactions
for CEP89 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEP89
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for CEP89 (Q96ST83 ENSP000003061054) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CEP89 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CEP89
Search CenterWatch for drugs/clinical trials and news about CEP89
|
Transcripts
for CEP89 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CEP89 gene: NM_032816.3 Unigene Cluster for CEP89: Centrosomal protein 89kDa Hs.599703 [show with all ESTs]Unigene Representative Sequence: AK0013758 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000305768(uc002ntx.3 uc002nty.3 uc010edg.3 uc002nua.3 uc002nub.1 uc002nuc.1)
ENST00000591698 ENST00000586984 ENST00000590597 ENST00000593276 ENST00000591205
ENST00000591863 ENST00000592401
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP89 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP89 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CEP89 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEP89 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP89 |
Additional cDNA sequence: AK001375.1 AK023102.1 AK027546.1 AL832158.1 BC012783.2 BC020195.1 BC029978.1 BC032307.1 BC136328.1 7 DOTS entries: DT.92064670 DT.40249849 DT.91755699 DT.100020620 DT.91741312 DT.121504931 DT.100749740 24/90 AceView cDNA sequences (see all 90): BM704296 BI764104 AW162358 AW732254 CR591015 AA436095 BU628988 BE393029 CR593458 AA553761 BU621560 AW163431 AU130698 CA427382 BC032307 CN483426 NM_032816 BU196203 BX282732 BM811174 BX108919 BF205109 BU632101 BC029978
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CEP89 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CEP89
|
Expression
for CEP89 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CEP89 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGCAGCCG
About this image
See CEP89 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEP89
SOURCE GeneReport for Unigene cluster: Hs.599703
SABiosciences Custom PCR Arrays for CEP89
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP89
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CEP89 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP89 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP89 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP89 |
Orthologs
for CEP89 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CEP89 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for CEP89 (if available)
TreeFam Gene Tree for CEP89 (if available) |
Paralogs
for CEP89 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CEP89 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CEP89 (33369904 - 33462897 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CEP89: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP89 |
|
Disorders
/ Diseases
for CEP89 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CEP89 for disorders About GeneDecksing
1  disease for CEP89: About MalaCardskidney disease
Export disorders for CEP89 gene to outside databases
|
Publications
for CEP89 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CEP89 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with CEP89) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human-specific nonsense mutations identified by genome sequence comparisons. (PubMed id 16395595)1, 3 Hahn Y. and Lee B. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PubMed id 21399614)2 Jakobsen L.... Andersen J.S. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genetic loci influencing kidney function and chronic kidney disease. (PubMed id 20383145)1 Chambers J.C....Kooner J.S. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for CEP89 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CEP89 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CEP89 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CEP89 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CEP89 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CEP89 gene:
Search GeneIP for patents involving CEP89
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CEP89 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CEP89 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEP89 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP89 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CEP89 | | OriGene 3'-UTR Clone for CEP89 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP89 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP89 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CEP89 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP89 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP89 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEP89 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP89 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP89 |
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 |  |  |  | |
| | | | Search Tocris compounds for CEP89 |
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 | | | CEP89 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP89 |
|  |  |  |  | | | | ThermoFisher Antibodies for CEP89 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP89 |
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