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Aliases for CEP85L Gene

Aliases for CEP85L Gene

  • Centrosomal Protein 85 Like 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-15 3 4
  • Centrosomal Protein 85kDa-Like 2 3
  • C6orf204 3 4
  • Chromosome 6 Open Reading Frame 204 2
  • Centrosomal Protein Of 85 KDa-Like 3
  • BA57K17.2 3
  • NY-BR-15 3

External Ids for CEP85L Gene

Previous HGNC Symbols for CEP85L Gene

  • C6orf204

Previous GeneCards Identifiers for CEP85L Gene

  • GC06M118782

Summaries for CEP85L Gene

Entrez Gene Summary for CEP85L Gene

  • The protein encoded by this gene was identified as a breast cancer antigen. Nothing more is known of its function at this time. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for CEP85L Gene

CEP85L (Centrosomal Protein 85 Like) is a Protein Coding gene. Diseases associated with CEP85L include Myeloproliferative Neoplasm and Lymphoblastic Lymphoma. An important paralog of this gene is CEP85.

Additional gene information for CEP85L Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP85L Gene

Genomics for CEP85L Gene

Regulatory Elements for CEP85L Gene

Enhancers for CEP85L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H118890 1.7 FANTOM5 ENCODE dbSUPER 13.3 -184.2 -184150 6.8 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MCM9 CEP85L ENSG00000253194 FAM184A ASF1A
GH06H118807 1.1 FANTOM5 Ensembl ENCODE 20.3 -99.5 -99459 3.2 PKNOX1 RUNX3 SPI1 GABPA MCM9 CEP85L ASF1A FAM184A LOC100287632
GH06H118767 1.2 FANTOM5 Ensembl ENCODE 13.7 -58.6 -58628 2.2 SMARCE1 ZNF362 HLF CEBPB DPF2 ZKSCAN1 FOXA1 ZNF217 CTBP1 GATA3 CEP85L LOC100287632 FAM184A MCM9 ASF1A
GH06H119260 1.3 Ensembl ENCODE 10 -551.4 -551437 1.8 PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B YY1 SLC30A9 FOS ATF7 RNU6-194P CEP85L RPL13AP15 GC06P119180
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEP85L on UCSC Golden Path with GeneCards custom track

Promoters for CEP85L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000201808 682 1201 PKNOX1 ATF1 ARNT SIN3A FEZF1 YY1 TCF12 ZNF766 CBX5 GATA2

Genomic Locations for CEP85L Gene

Genomic Locations for CEP85L Gene
249,311 bases
Minus strand

Genomic View for CEP85L Gene

Genes around CEP85L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP85L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP85L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP85L Gene

Proteins for CEP85L Gene

  • Protein details for CEP85L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Centrosomal protein of 85 kDa-like
    Protein Accession:
    Secondary Accessions:
    • A1A4E1
    • A2A3P2
    • A2IDE5
    • F8W6J2
    • G3V0H3
    • Q2TAM2
    • Q5T323
    • Q7Z5K7
    • Q9H289

    Protein attributes for CEP85L Gene

    805 amino acids
    Molecular mass:
    91808 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI10836.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAM19611.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM28257.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP85L Gene


neXtProt entry for CEP85L Gene

Post-translational modifications for CEP85L Gene

  • Ubiquitination at Lys453
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP85L Gene

Domains & Families for CEP85L Gene

Gene Families for CEP85L Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for CEP85L Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CEP85 family.
  • Belongs to the CEP85 family.
genes like me logo Genes that share domains with CEP85L: view

Function for CEP85L Gene

Phenotypes From GWAS Catalog for CEP85L Gene

Phenotypes for CEP85L Gene

genes like me logo Genes that share phenotypes with CEP85L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP85L Gene

Localization for CEP85L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP85L Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Subcellular experiments using a GFP-tagged system produced a weak signal, rendering it difficult to confirm centrosome association.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP85L gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for CEP85L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome TAS 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CEP85L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CEP85L Gene

Pathways & Interactions for CEP85L Gene

SuperPathways for CEP85L Gene

No Data Available

Interacting Proteins for CEP85L Gene

Gene Ontology (GO) - Biological Process for CEP85L Gene


No data available for Pathways by source and SIGNOR curated interactions for CEP85L Gene

Drugs & Compounds for CEP85L Gene

No Compound Related Data Available

Transcripts for CEP85L Gene

Unigene Clusters for CEP85L Gene

Centrosomal protein 85kDa-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP85L Gene

No ASD Table

Relevant External Links for CEP85L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CEP85L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEP85L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEP85L Gene

This gene is overexpressed in Testis (x4.2).

Protein differential expression in normal tissues from HIPED for CEP85L Gene

This gene is overexpressed in Plasma (50.2) and Thyroid (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CEP85L Gene

NURSA nuclear receptor signaling pathways regulating expression of CEP85L Gene:


SOURCE GeneReport for Unigene cluster for CEP85L Gene:


mRNA Expression by UniProt/SwissProt for CEP85L Gene:

Tissue specificity: Isoform 1 and isoform 4 are expressed in spleen, lymph, thymus, tonsil and peripheral blood leukocytes, with isoform 1 expressed at higher levels. Isoform 4 is detected in K-562 leukemia cells and in the blood of precursor T lymphoblastic lymphoma (T-ALL) patients.

Evidence on tissue expression from TISSUES for CEP85L Gene

  • Lung(4.2)
  • Blood(4.1)
  • Nervous system(3.6)
  • Kidney(2.5)
genes like me logo Genes that share expression patterns with CEP85L: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP85L Gene

Orthologs for CEP85L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP85L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CEP85L 34
  • 96 (a)
(Canis familiaris)
Mammalia CEP85L 33 34
  • 91.77 (n)
(Bos Taurus)
Mammalia CEP85L 33 34
  • 90.8 (n)
(Mus musculus)
Mammalia Cep85l 33 16 34
  • 86.38 (n)
(Rattus norvegicus)
Mammalia LOC100365935 33
  • 85.07 (n)
(Monodelphis domestica)
Mammalia CEP85L 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia CEP85L 34
  • 68 (a)
(Gallus gallus)
Aves CEP85L 33 34
  • 72.37 (n)
(Anolis carolinensis)
Reptilia CEP85L 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cep85l 33
  • 59.95 (n)
(Danio rerio)
Actinopterygii cep85l 33 34
  • 54.21 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 22 (a)
Species where no ortholog for CEP85L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP85L Gene

Gene Tree for CEP85L (if available)
Gene Tree for CEP85L (if available)

Paralogs for CEP85L Gene

Paralogs for CEP85L Gene

(3) SIMAP similar genes for CEP85L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CEP85L: view

Variants for CEP85L Gene

Sequence variations from dbSNP and Humsavar for CEP85L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_036247 A breast cancer sample
rs111033559 Pathogenic 118,558,946(+) TCACT(C/T)GCTCA intron-variant, reference, missense
rs111033560 Pathogenic 118,559,037(+) CATCT(G/T)AATAT intron-variant, reference, stop-gained
rs397516784 Pathogenic 118,558,961(+) TAAGA(-/AGA)GCCTC intron-variant, cds-indel
rs12198461 Likely benign 118,559,477(+) CAATG(A/G/T)AAAAG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CEP85L Gene

Variant ID Type Subtype PubMed ID
nsv969439 CNV duplication 23825009
nsv830788 CNV gain 17160897
nsv830787 CNV loss 17160897
nsv604555 CNV gain 21841781
nsv525925 CNV loss 19592680
nsv525179 CNV gain 19592680
nsv464029 CNV gain 19166990
nsv1161446 CNV duplication 26073780
nsv1140686 CNV deletion 24896259
nsv1125886 CNV tandem duplication 24896259
nsv1074009 CNV deletion 25765185
nsv1034448 CNV gain 25217958
nsv1030331 CNV gain 25217958
nsv1020586 CNV gain 25217958
nsv1020463 CNV gain 25217958
nsv1019357 CNV gain 25217958
esv4141 OTHER sequence alteration 18987735
esv3890931 CNV gain 25118596
esv3867 CNV loss 18987735
esv3610523 CNV loss 21293372
esv3610522 CNV loss 21293372
esv3610520 CNV gain 21293372
esv3610519 CNV loss 21293372
esv3610517 CNV gain 21293372
esv3610516 CNV loss 21293372
esv3610513 CNV loss 21293372
esv3571371 CNV loss 25503493
esv3540363 CNV deletion 23714750
esv3435797 CNV insertion 20981092
esv275552 CNV loss 21479260
esv27506 CNV loss 19812545
esv2732624 CNV deletion 23290073
esv2665977 CNV deletion 23128226
esv2581079 CNV deletion 19546169
esv2440070 CNV deletion 19546169
esv2333041 CNV deletion 18987734
dgv1826e212 CNV gain 25503493
dgv1213e214 CNV gain 21293372
dgv10919n54 CNV gain 21841781
dgv10918n54 CNV gain 21841781

Variation tolerance for CEP85L Gene

Residual Variation Intolerance Score: 64.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.44; 71.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP85L Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP85L Gene

Disorders for CEP85L Gene

MalaCards: The human disease database

(3) MalaCards diseases for CEP85L Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
myeloproliferative neoplasm
  • campomelic dysplasia
lymphoblastic lymphoma
  • lymphoma, lymphoblastic
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving CEP85L is found in a patient with T-lymphoblastic lymphoma (T-ALL) and an associated myeloproliferative neoplasm (MPN) with eosinophilia. Translocation t(5;6)(q33-34;q23) with PDGFRB. The translocation fuses the 5-end of CEP85L (isoform 4) to the 3-end of PDGFRB. {ECO:0000269 PubMed:21938754}.

Relevant External Links for CEP85L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CEP85L: view

No data available for Genatlas for CEP85L Gene

Publications for CEP85L Gene

  1. Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm. (PMID: 21938754) Chmielecki J … Pao W (Genes, chromosomes & cancer 2012) 3 4 60
  2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L … Andersen JS (The EMBO journal 2011) 3 4 60
  3. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan MJ … Old LJ (Cancer immunity 2001) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 60

Products for CEP85L Gene

Sources for CEP85L Gene

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