CEP85L Gene
protein-coding GIFtS: 39
GCID: GC06M118782
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centrosomal protein 85kDa-like(Previous name: chromosome 6 open reading frame 204 )
(Previous symbol: C6orf204)
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Aliases
for CEP85L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Centrosomal Protein 85kDa-Like1 2 | | Serologically Defined Breast Cancer Antigen NY-BR-152 3 | | C6orf2041 2 3 | | Chromosome 6 Open Reading Frame 2041 | | NY-BR-151 2 | | Centrosomal Protein Of 85 KDa-Like2 | | BA57K17.21 | | |
Export aliases for CEP85L gene to outside databases |
Summaries
for CEP85L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CEP85L:
The protein encoded by this gene was identified as a breast cancer antigen. Nothing more is known of its function atthis time. Three transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq,May 2010)
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Genomic Views
for CEP85L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CEP85L
Other transcription factors
Search SABiosciences Chromatin IP Primers for CEP85L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP85L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q22 Ensembl cytogenetic band: 6q22.31 HGNC cytogenetic band: 6q22.31CEP85L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M118782: view genomic region
(about GC identifiers)
Start:
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118,781,935 bp from pter |
End:
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119,031,238 bp from pter |
Size:
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249,304 bases |
Orientation:
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minus strand |
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Proteins
for CEP85L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CE85L_HUMAN, Q5SZL2 (See
protein sequence)Recommended Name: Centrosomal protein of 85 kDa-like Size: 805 amino acids; 91808 Da
Subcellular location: Cytoplasm, cytoskeleton, centrosome (Probable). Note=Subcellular experiments using a GFP-taggedsystem produced a weak signal, rendering it difficult to confirm centrosome association
Sequence caution: Sequence=AAI10836.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAM19611.1; Type=Erroneous gene model prediction; Sequence=CAM28257.1; Type=Erroneous gene model prediction;
Secondary accessions: A1A4E1 A2A3P2 A2IDE5 F8W6J2 G3V0H3 Q2TAM2 Q5T323 Q7Z5K7 Q9H289Alternative splicing: 5 isoforms: Q5SZL2-1 Q5SZL2-2 Q5SZL2-3 Q5SZL2-4 Q5SZL2-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CEP85L: NX_Q5SZL2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5SZL2
CEP85L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001035940.1 NP_001171506.1 NP_996804.2
ENSEMBL proteins: ENSP00000357477 ENSP00000392131 ENSP00000376288 ENSP00000353434 ENSP00000393317 ENSP00000357474
Human Recombinant Protein Products for CEP85L:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CEP85L for ontologies About GeneDecksing
CEP85L Antibody Products:
Assay Products for CEP85L: |
Protein
Domains /
Families
for CEP85L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5SZL2 UniProtKB/Swiss-Prot: CE85L_HUMAN, Q5SZL2Similarity: Belongs to the CEP85 family |
Function
for CEP85L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP85L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP85L (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP85L |
|
Pathways & Interactions
for CEP85L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEP85L
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for CEP85L (Q5SZL23 ENSP000003574774) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CEP85L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CEP85L
Search CenterWatch for drugs/clinical trials and news about CEP85L / CE85L
|
Transcripts
for CEP85L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CEP85L gene (3 alternative transcripts): NM_001042475.2 NM_001178035.1 NM_206921.2 Unigene Cluster for CEP85L: Centrosomal protein 85kDa-like Hs.656959 [show with all ESTs]Unigene Representative Sequence: NM_00104247511 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368491(uc003pxz.2) ENST00000434604 ENST00000392500(uc003pyc.3)
ENST00000360290(uc011ebj.2) ENST00000419517(uc003pyb.3) ENST00000483035(uc011ebl.1)
ENST00000472713 ENST00000476150 ENST00000462101 ENST00000489276 ENST00000368488(uc003pya.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP85L (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP85L (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CEP85L | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEP85L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP85L |
Additional cDNA sequence: AF131811.1 AF308284.1 AK302591.1 AL133101.1 AY313778.1 BC036553.1 BC045657.1 BC048977.1 BC052778.1 BC064835.1 BC110835.1 BC126140.1 BC126142.1 8 DOTS entries: DT.75151433 DT.95367538 DT.121381776 DT.86845911 DT.102828290 DT.406336 DT.430592 DT.91921431 24/75 AceView cDNA sequences (see all 75): AI660060 AI635527 BC064835 BU741754 AA938309 AW958301 AA489223 AI377047 AA856722 BM723381 AA459978 AW088116 AA311065 AA621378 AW183379 AY313778 BU634441 NM_206921 BM925238 AA767492 AW629202 AW593214 BM724601 BG399369
GeneLoc Exon Structure
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Expression
for CEP85L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CEP85L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTAATTGA
About this image
See CEP85L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEP85L
SOURCE GeneReport for Unigene cluster: Hs.656959
UniProtKB/Swiss-Prot: CE85L_HUMAN, Q5SZL2Tissue specificity: Isoform 1 and isoform 4 are expressed in spleen, lymph, thymus, tonsil and peripheral bloodleukocytes, with isoform 1 expressed at higher levels. Isoform 4 is detected in K-562 leukemia cells and in the bloodof precursor T lymphoblastic lymphoma (T-ALL) patients
SABiosciences Custom PCR Arrays for CEP85L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP85L
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CEP85L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP85L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP85L | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP85L |
Orthologs
for CEP85L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CEP85L gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for CEP85L (if available)
TreeFam Gene Tree for CEP85L (if available) |
Paralogs
for CEP85L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CEP85L gene
- CEP852
3 SIMAP similar genes for CEP85L using alignment to 2 protein entries: CE85L_HUMAN (see all proteins):C6orf204 DKFZp434P232 CEP85
CEP85L for paralogs About GeneDecksing
|
Genomic Variants
for CEP85L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CEP85L (118781935 - 119031238 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CEP85L: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP85L |
|
Disorders
/ Diseases
for CEP85L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CEP85L for disorders About GeneDecksing
UniProtKB/Swiss-Prot: CE85L_HUMAN, Q5SZL2
Note=A chromosomal aberration involving CEP85L is found in a patient with T-lymphoblastic lymphoma (T-ALL) andan associated myeloproliferative neoplasm (MPN) with eosinophilia. Translocation t(5;6)(q33-34;q23) with PDGFRB. Thetranslocation fuses the 5'-end of CEP85L (isoform 4) to the 3'-end of PDGFRB
5  diseases for CEP85L: About MalaCardsbreast cancer lymphoblastic lymphoma tonsillitis gout
leukemia
Export disorders for CEP85L gene to outside databases
|
Publications
for CEP85L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CEP85L gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with CEP85L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm. (PubMed id 21938754)1, 2 Chmielecki J.... Pao W. (2012)
- Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PubMed id 12747765)1, 2 Scanlan M.J.... Old L.J. (2001)
- Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
- A genome-wide association study identifies a novel sus ceptibility locus for renal cell carcinoma on 12p11.23. (PubMed id 22010048)1 Wu X....Chanock S.J. (2012)
- Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PubMed id 21399614)2 Jakobsen L.... Andersen J.S. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genome-wide association analysis identifies multiple loci related to resting heart rate. (PubMed id 20639392)1 Eijgelsheim M....O'Donnell C.J. (2010)
- Genetic variants associated with cardiac structure an d function: a meta-analysis and replication of genome-wide association data. (PubMed id 19584346)1 Vasan R.S....Blankenberg S. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
|
External Searches for CEP85L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CEP85L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CEP85L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CEP85L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CEP85L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CEP85L gene:
Search GeneIP for patents involving CEP85L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CEP85L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CEP85L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP85L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP85L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEP85L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP85L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP85L |
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 | | | CEP85L Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP85L |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CEP85L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP85L |
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