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Aliases for CEP85L Gene

Aliases for CEP85L Gene

  • Centrosomal Protein 85kDa-Like 2 3
  • Serologically Defined Breast Cancer Antigen NY-BR-15 3 4
  • C6orf204 3 4
  • Chromosome 6 Open Reading Frame 204 2
  • Centrosomal Protein Of 85 KDa-Like 3
  • BA57K17.2 3
  • NY-BR-15 3

External Ids for CEP85L Gene

Previous HGNC Symbols for CEP85L Gene

  • C6orf204

Previous GeneCards Identifiers for CEP85L Gene

  • GC06M118782

Summaries for CEP85L Gene

Entrez Gene Summary for CEP85L Gene

  • The protein encoded by this gene was identified as a breast cancer antigen. Nothing more is known of its function at this time. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for CEP85L Gene

CEP85L (Centrosomal Protein 85kDa-Like) is a Protein Coding gene. Diseases associated with CEP85L include breast cancer. An important paralog of this gene is CEP85.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP85L Gene

Genomics for CEP85L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CEP85L Gene

118,460,772 bp from pter
118,710,075 bp from pter
249,304 bases
Minus strand

Genomic View for CEP85L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP85L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP85L Gene

No data available for Regulatory Elements for CEP85L Gene

Proteins for CEP85L Gene

  • Protein details for CEP85L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Centrosomal protein of 85 kDa-like
    Protein Accession:
    Secondary Accessions:
    • A1A4E1
    • A2A3P2
    • A2IDE5
    • F8W6J2
    • G3V0H3
    • Q2TAM2
    • Q5T323
    • Q7Z5K7
    • Q9H289

    Protein attributes for CEP85L Gene

    805 amino acids
    Molecular mass:
    91808 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI10836.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAM19611.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAM28257.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP85L Gene


neXtProt entry for CEP85L Gene

Proteomics data for CEP85L Gene at MOPED

Post-translational modifications for CEP85L Gene

  • Ubiquitination at Lys453
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP85L Gene

No data available for DME Specific Peptides for CEP85L Gene

Domains for CEP85L Gene

Protein Domains for CEP85L Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CEP85 family.
  • Belongs to the CEP85 family.
genes like me logo Genes that share domains with CEP85L: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CEP85L Gene

Function for CEP85L Gene

Animal Model Products

miRNA for CEP85L Gene

miRTarBase miRNAs that target CEP85L

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP85L

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEP85L Gene

Localization for CEP85L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP85L Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Subcellular experiments using a GFP-tagged system produced a weak signal, rendering it difficult to confirm centrosome association.

Gene Ontology (GO) - Cellular Components for CEP85L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome TAS 21399614
genes like me logo Genes that share ontologies with CEP85L: view

No data available for Subcellular locations from COMPARTMENTS for CEP85L Gene

Pathways for CEP85L Gene

SuperPathways for CEP85L Gene

No Data Available

Interacting Proteins for CEP85L Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000357474 Q5SZL2-CE85L_HUMAN for CEP85L Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CEP85L Gene


No data available for Pathways by source for CEP85L Gene

Transcripts for CEP85L Gene

Unigene Clusters for CEP85L Gene

Centrosomal protein 85kDa-like:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP85L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP85L Gene

No ASD Table

Relevant External Links for CEP85L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CEP85L Gene

mRNA expression in normal human tissues for CEP85L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEP85L Gene

This gene is overexpressed in Testis (4.2).

Protein differential expression in normal tissues for CEP85L Gene

This gene is overexpressed in Plasma (50.2) and Thyroid (10.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CEP85L Gene

SOURCE GeneReport for Unigene cluster for CEP85L Gene Hs.656959

mRNA Expression by UniProt/SwissProt for CEP85L Gene

Tissue specificity: Isoform 1 and isoform 4 are expressed in spleen, lymph, thymus, tonsil and peripheral blood leukocytes, with isoform 1 expressed at higher levels. Isoform 4 is detected in K-562 leukemia cells and in the blood of precursor T lymphoblastic lymphoma (T-ALL) patients.
genes like me logo Genes that share expressions with CEP85L: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Expression partners for CEP85L Gene

Orthologs for CEP85L Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP85L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CEP85L 35
  • 90.8 (n)
  • 90.42 (a)
CEP85L 36
  • 90 (a)
(Canis familiaris)
Mammalia CEP85L 35
  • 91.77 (n)
  • 91.82 (a)
CEP85L 36
  • 92 (a)
(Mus musculus)
Mammalia Cep85l 35
  • 86.38 (n)
  • 86.46 (a)
Cep85l 16
Cep85l 36
  • 84 (a)
(Rattus norvegicus)
Mammalia LOC100365935 35
  • 85.07 (n)
  • 84.58 (a)
(Monodelphis domestica)
Mammalia CEP85L 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia CEP85L 36
  • 68 (a)
(Pan troglodytes)
Mammalia CEP85L 36
  • 96 (a)
(Gallus gallus)
Aves CEP85L 35
  • 72.37 (n)
  • 68.8 (a)
CEP85L 36
  • 67 (a)
(Anolis carolinensis)
Reptilia CEP85L 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cep85l 35
  • 59.95 (n)
  • 52.67 (a)
(Danio rerio)
Actinopterygii cep85l 35
  • 54.21 (n)
  • 51.37 (a)
cep85l 36
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
Species with no ortholog for CEP85L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP85L Gene

Gene Tree for CEP85L (if available)
Gene Tree for CEP85L (if available)

Paralogs for CEP85L Gene

Paralogs for CEP85L Gene

(3) SIMAP similar genes for CEP85L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CEP85L: view

Variants for CEP85L Gene

Sequence variations from dbSNP and Humsavar for CEP85L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs25421 -- 118,486,836(-) GATGT(C/T)AGAGT intron-variant
rs25422 -- 118,486,684(-) GAGGG(A/G)ATAGA intron-variant
rs25423 -- 118,486,628(-) TTCTT(C/G)AAGGG intron-variant
rs387819 -- 118,568,164(+) GCAGT(A/G)ACAGA intron-variant
rs403684 -- 118,617,259(+) cttat(A/G)tgttt intron-variant

Relevant External Links for CEP85L Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CEP85L Gene

Disorders for CEP85L Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CEP85L Gene in MalaCards »

(1) Disease for CEP85L Gene


  • Note=A chromosomal aberration involving CEP85L is found in a patient with T-lymphoblastic lymphoma (T-ALL) and an associated myeloproliferative neoplasm (MPN) with eosinophilia. Translocation t(5;6)(q33-34;q23) with PDGFRB. The translocation fuses the 5-end of CEP85L (isoform 4) to the 3-end of PDGFRB.
genes like me logo Genes that share disorders with CEP85L: view

No data available for OMIM , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CEP85L Gene

Publications for CEP85L Gene

  1. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. (PMID: 12747765) Scanlan M.J. … Old L.J. (Cancer Immun. 2001) 3 4
  2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L. … Andersen J.S. (EMBO J. 2011) 3 4
  3. Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm. (PMID: 21938754) Chmielecki J. … Pao W. (Genes Chromosomes Cancer 2012) 3 4
  4. A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23. (PMID: 22010048) Wu X. … Chanock S.J. (Hum. Mol. Genet. 2012) 3
  5. Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks. (PMID: 22558309) Wong K.A. … O'Bryan J.P. (PLoS ONE 2012) 3

Products for CEP85L Gene

Sources for CEP85L Gene

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