CEP85 Gene
protein-coding GIFtS: 41
GCID: GC01P026561
|
|
centrosomal protein 85kDa(Previous name: coiled-coil domain containing 21 )
(Previous symbol: CCDC21)
| |
Aliases
for CEP85 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Centrosomal Protein 85kDa1 2 | | CCDC211 2 3 | | Coiled-Coil Domain Containing 211 2 | | Coiled-Coil Domain-Containing Protein 212 3 | | DKFZP434L01171 | | Centrosomal Protein Of 85 KDa2 |
Export aliases for CEP85 gene to outside databases |
Summaries
for CEP85 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CEP85 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CEP85
Other transcription factors
Search SABiosciences Chromatin IP Primers for CEP85
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP85 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.11 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p36.11CEP85 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P026561: view genomic region
(about GC identifiers)
Start:
|
26,560,691 bp from pter |
End:
|
26,605,299 bp from pter |
Size:
|
44,609 bases |
Orientation:
|
plus strand |
|
Proteins
for CEP85 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CEP85_HUMAN, Q6P2H3 (See
protein sequence)Recommended Name: Centrosomal protein of 85 kDa Size: 762 amino acids; 85639 Da
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus, nucleolus.Note=Localizes to centrosomes and nucleolus in interphase. Upon entry into mitosis, relocates from nucleolus andaccumulates at spindle poles
Sequence caution: Sequence=BAB15203.1; Type=Erroneous initiation; Sequence=CAH71541.2; Type=Erroneous gene modelprediction; Sequence=CAI15849.2; Type=Erroneous gene model prediction;
Secondary accessions: D3DPK4 Q5VY68 Q5VY70 Q9H6Q1 Q9H828 Q9UF52Alternative splicing: 3 isoforms: Q6P2H3-1 Q6P2H3-2 Q6P2H3-3 Explore the universe of human proteins at neXtProt for CEP85: NX_Q6P2H3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6P2H3
CEP85 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_073615.2
ENSEMBL proteins: ENSP00000432354 ENSP00000252992 ENSP00000391790 ENSP00000417002
Human Recombinant Protein Products for CEP85:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CEP85 for ontologies About GeneDecksing
CEP85 Antibody Products:
Assay Products for CEP85: |
Protein
Domains /
Families
for CEP85 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6P2H3 UniProtKB/Swiss-Prot: CEP85_HUMAN, Q6P2H3Similarity: Belongs to the CEP85 family |
Function
for CEP85 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
2 GenomeRNAi human phenotypes for CEP85:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP85 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP85
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for CEP85 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEP85 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP85 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP85 |
|
Pathways & Interactions
for CEP85 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEP85
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for CEP85 (Q6P2H32 ENSP000002529924) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CEP85 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CEP85
Search CenterWatch for drugs/clinical trials and news about CEP85
|
Transcripts
for CEP85 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CEP85 gene: NM_022778.2 Unigene Cluster for CEP85: Centrosomal protein 85kDa Hs.63795 [show with all ESTs]Unigene Representative Sequence: BC0645288 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000476272 ENST00000252992(uc001blr.3 uc001bls.1 uc010ofa.1)
ENST00000480446 ENST00000453146 ENST00000469609(uc001blt.1) ENST00000468163
ENST00000491670 ENST00000451429
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP85 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP85
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CEP85 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEP85 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP85 |
Additional cDNA sequence: AK024038.1 AK025653.1 AK299312.1 AL133609.1 AL137420.1 BC019902.1 BC064528.1 10 DOTS entries: DT.100780905 DT.97842188 DT.441366 DT.92429001 DT.97786069 DT.92429000 DT.100697892 DT.121392216 DT.121392304 DT.95374576 24/610 AceView cDNA sequences (see all 610): AA331050 AK024884 AJ708115 BQ772782 CB155204 AI608877 CR593489 BQ330614 BQ053149 BU617183 AA988905 BI089025 AW293916 CA426060 BM856435 BG118399 CF128419 BM708491 BM193857 BC064528 CA417248 BU753425 AA364016 BI045094
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CEP85 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | · | 15c | ^ | 16a | · | 16b | ^ | 17a | · | 17b | ^ | 18a | · | 18b |
|---|
|
| SP1: | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | - | | | | - | | | | | | | | - | | | | | | |
| SP2: | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | - | | | | - | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CEP85
|
Expression
for CEP85 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CEP85 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGACGGGTA
About this image
See CEP85 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEP85
SOURCE GeneReport for Unigene cluster: Hs.63795
SABiosciences Custom PCR Arrays for CEP85
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP85
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CEP85 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP85 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP85 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP85 |
Orthologs
for CEP85 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CEP85 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CEP851 |
centrosomal protein 85kDa |
66.19(n)
61.81(a) |
|
419547 XM_417697.3 XP_417697.2 |
lizard
(Anolis carolinensis) |
Reptilia |
CEP856 |
-- |
54(a) |
1 ↔ 1 |
GL343480.1(431548-441983) |
African clawed frog
(Xenopus laevis) |
Amphibia |
CA972522.12 |
-- |
75.87(n) |
|
CA972522.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
AL914878.12 |
-- |
78.17(n) |
|
AL914878.1 |
ENSEMBL Gene Tree for CEP85 (if available)
TreeFam Gene Tree for CEP85 (if available) |
Paralogs
for CEP85 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CEP85 gene
- CEP85L2
2 SIMAP similar genes for CEP85 using alignment to 3 protein entries: CEP85_HUMAN (see all proteins):DKFZp434P232 CEP85L
CEP85 for paralogs About GeneDecksing
|
Genomic Variants
for CEP85 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CEP85 (26560691 - 26605299 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CEP85: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP85 |
|
Disorders
/ Diseases
for CEP85 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CEP85 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CEP85 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with CEP85) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PubMed id 21399614)2 Jakobsen L.... Andersen J.S. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for CEP85 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CEP85 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CEP85 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CEP85 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CEP85 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CEP85 gene:
Search GeneIP for patents involving CEP85
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CEP85 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CEP85 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEP85 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP85 | | | OriGene Protein Over-expression Lysate for CEP85 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CEP85 | | OriGene 3'-UTR Clone for CEP85 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP85 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP85 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CEP85 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CEP85 | | OriGene Custom Protein Services for CEP85 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CEP85 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP85 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP85 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEP85 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP85 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP85 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CEP85 |
| |  |  |  |  | | | | |
 |
 |
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 | | | CEP85 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP85 |
|  |  |  |  | | | | ThermoFisher Antibodies for CEP85 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP85 |
| |  | |
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