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Aliases for CEP85 Gene

Aliases for CEP85 Gene

  • Centrosomal Protein 85 2 3
  • Centrosomal Protein 85kDa 2 3 5
  • Coiled-Coil Domain-Containing Protein 21 3 4
  • CCDC21 3 4
  • Coiled-Coil Domain Containing 21 2
  • Cep85 4

External Ids for CEP85 Gene

Previous HGNC Symbols for CEP85 Gene

  • CCDC21

Previous GeneCards Identifiers for CEP85 Gene

  • GC01P026561

Summaries for CEP85 Gene

Entrez Gene Summary for CEP85 Gene

  • This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for CEP85 Gene

CEP85 (Centrosomal Protein 85) is a Protein Coding gene. An important paralog of this gene is CEP85L.

UniProtKB/Swiss-Prot for CEP85 Gene

  • Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP85 Gene

Genomics for CEP85 Gene

Regulatory Elements for CEP85 Gene

Promoters for CEP85 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEP85 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEP85 Gene

Chromosome:
1
Start:
26,234,153 bp from pter
End:
26,279,038 bp from pter
Size:
44,886 bases
Orientation:
Plus strand

Genomic View for CEP85 Gene

Genes around CEP85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP85 Gene

Proteins for CEP85 Gene

  • Protein details for CEP85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2H3-CEP85_HUMAN
    Recommended name:
    Centrosomal protein of 85 kDa
    Protein Accession:
    Q6P2H3
    Secondary Accessions:
    • B4DRL1
    • D3DPK4
    • F8W7K4
    • Q5VY68
    • Q5VY70
    • Q9H6Q1
    • Q9H828
    • Q9UF52

    Protein attributes for CEP85 Gene

    Size:
    762 amino acids
    Molecular mass:
    85639 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15203.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP85 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP85 Gene

Proteomics data for CEP85 Gene at MOPED

Post-translational modifications for CEP85 Gene

  • Ubiquitination at Lys 139, Lys 178, Lys 357, Lys 401, and Lys 633
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP85 Gene

No data available for DME Specific Peptides for CEP85 Gene

Domains & Families for CEP85 Gene

Protein Domains for CEP85 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP85 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P2H3

UniProtKB/Swiss-Prot:

CEP85_HUMAN :
  • Belongs to the CEP85 family.
Family:
  • Belongs to the CEP85 family.
genes like me logo Genes that share domains with CEP85: view

No data available for Gene Families for CEP85 Gene

Function for CEP85 Gene

Molecular function for CEP85 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856).
genes like me logo Genes that share phenotypes with CEP85: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP85 Gene

Localization for CEP85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP85 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus, nucleolus. Note=Localizes to centrosomes and nucleolus in interphase. Upon entry into mitosis, relocates from nucleolus and accumulates at spindle poles (PubMed:21399614). Associated with the pericentriolar material. Localizes to centrosomes at a low level in G1 phase and a slightly increased level in S phase, with gradually elevated levels during G2 phase. The levels at centrosomes further increase at G2/M, reaching a peak at spindle poles at early mitotic stages and remain high until the end of anaphase (PubMed:26220856). {ECO:0000269 PubMed:21399614, ECO:0000269 PubMed:26220856}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP85 Gene COMPARTMENTS Subcellular localization image for CEP85 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CEP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with CEP85: view

Pathways & Interactions for CEP85 Gene

SuperPathways for CEP85 Gene

No Data Available

Interacting Proteins for CEP85 Gene

Gene Ontology (GO) - Biological Process for CEP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046602 regulation of mitotic centrosome separation IMP 26220856
genes like me logo Genes that share ontologies with CEP85: view

No data available for Pathways by source and SIGNOR curated interactions for CEP85 Gene

Drugs & Compounds for CEP85 Gene

No Compound Related Data Available

Transcripts for CEP85 Gene

Unigene Clusters for CEP85 Gene

Centrosomal protein 85kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP85 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7: -
SP8:

Relevant External Links for CEP85 Gene

GeneLoc Exon Structure for
CEP85
ECgene alternative splicing isoforms for
CEP85

Expression for CEP85 Gene

mRNA expression in normal human tissues for CEP85 Gene

mRNA differential expression in normal tissues according to GTEx for CEP85 Gene

This gene is overexpressed in Muscle - Skeletal (x6.3).

Protein differential expression in normal tissues from HIPED for CEP85 Gene

This gene is overexpressed in Breast (52.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP85 Gene



SOURCE GeneReport for Unigene cluster for CEP85 Gene Hs.63795

genes like me logo Genes that share expression patterns with CEP85: view

Protein tissue co-expression partners for CEP85 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CEP85 Gene

Orthologs for CEP85 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP85 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEP85 35
  • 90.51 (n)
  • 89.2 (a)
CEP85 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP85 35
  • 91.27 (n)
  • 91.18 (a)
CEP85 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep85 35
  • 86.16 (n)
  • 85.55 (a)
Cep85 16
Cep85 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CEP85 35
  • 99.74 (n)
  • 99.74 (a)
CEP85 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep85 35
  • 84.94 (n)
  • 83.47 (a)
oppossum
(Monodelphis domestica)
Mammalia CEP85 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP85 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP85 35
  • 66.14 (n)
  • 61.81 (a)
CEP85 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP85 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8231 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-11i5.2 35
  • 57.35 (n)
  • 50.56 (a)
CEP85 36
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for CEP85:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP85 Gene

ENSEMBL:
Gene Tree for CEP85 (if available)
TreeFam:
Gene Tree for CEP85 (if available)

Paralogs for CEP85 Gene

Paralogs for CEP85 Gene

(2) SIMAP similar genes for CEP85 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CEP85: view

Variants for CEP85 Gene

Sequence variations from dbSNP and Humsavar for CEP85 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7550997 - 26,269,589(+) GAGAA(A/G)CAGAA reference, missense, utr-variant-5-prime
rs35831900 - 26,244,253(-) AACAG(C/T)GGCTG intron-variant, reference, missense
rs3795686 - 26,255,600(-) TTGTG(C/T)TGGTT reference, missense
rs36013141 - 26,276,636(-) GCCAG(A/C/G)TGGGC reference, missense
rs884533 -- 26,259,166(+) ttaaa(G/T)aattg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP85 Gene

Variant ID Type Subtype PubMed ID
dgv201n71 CNV Gain 21882294

Variation tolerance for CEP85 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.49; 82.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP85 Gene

HapMap Linkage Disequilibrium report
CEP85

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP85 Gene

Disorders for CEP85 Gene

Relevant External Links for CEP85

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP85

No disorders were found for CEP85 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP85 Gene

Publications for CEP85 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Proximity Interactions among Centrosome Components Identify Regulators of Centriole Duplication. (PMID: 24613305) Firat-Karalar E.N. … Stearns T. (Curr. Biol. 2014) 3
  4. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N. … Gallagher E. (EMBO J. 2014) 3
  5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3

Products for CEP85 Gene

Sources for CEP85 Gene

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