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Aliases for CEP85 Gene

Aliases for CEP85 Gene

  • Centrosomal Protein 85 2 3 5
  • Coiled-Coil Domain-Containing Protein 21 3 4
  • Centrosomal Protein 85kDa 2 3
  • CCDC21 3 4
  • Coiled-Coil Domain Containing 21 2
  • Centrosomal Protein Of 85 KDa 3
  • Cep85 4

External Ids for CEP85 Gene

Previous HGNC Symbols for CEP85 Gene

  • CCDC21

Previous GeneCards Identifiers for CEP85 Gene

  • GC01P026561

Summaries for CEP85 Gene

Entrez Gene Summary for CEP85 Gene

  • This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for CEP85 Gene

CEP85 (Centrosomal Protein 85) is a Protein Coding gene. An important paralog of this gene is CEP85L.

UniProtKB/Swiss-Prot for CEP85 Gene

  • Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP85 Gene

Genomics for CEP85 Gene

Regulatory Elements for CEP85 Gene

Enhancers for CEP85 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G026274 2 FANTOM5 Ensembl ENCODE dbSUPER 23.5 +49.7 49741 19.1 CREB3L1 AGO1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D ZNF610 GLIS1 CD52 UBXN11 CEP85 HMGN2 TRIM63 FAM110D NPM1P39 CRYBG2 CNKSR1 RPS6KA1
GH01G026348 2 FANTOM5 Ensembl ENCODE dbSUPER 16.9 +120.8 120780 12.2 MLX DMAP1 YY1 ZNF143 ZNF263 NFYC MEF2D SSRP1 GLIS1 RCOR2 CD52 ACTG1P20 UBXN11 CEP85 CNKSR1 CRYBG2 LIN28A DHDDS SLC30A2 TRIM63
GH01G026236 1.2 Ensembl ENCODE 13.5 +3.0 2969 2.2 HDAC1 HDGF NFRKB SIN3A CHAMP1 ZNF121 ZNF366 FOS MIER1 JUNB CD52 UBXN11 CEP85 ENSG00000236782 ZNF593 FAM110D CRYBG2 TRIM63 LOC101928324 HMGN2
GH01G026313 1.4 FANTOM5 ENCODE 10.9 +84.0 84017 8.4 HDGF PKNOX1 ATF1 WRNIP1 ARID4B BRCA1 ZNF2 ZNF48 ZNF766 GATA2 CD52 UBXN11 SH3BGRL3 ZNF683 CRYBG2 LIN28A CEP85 ENSG00000236782 ZNF593 FAM110D
GH01G026233 1.1 ENCODE 12.6 +0.4 433 2.3 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 CD52 ZNF593 UBXN11 HMGN2 NPM1P39 CEP85 ENSG00000236782 FAM110D PIR61351
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEP85 on UCSC Golden Path with GeneCards custom track

Promoters for CEP85 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000003525 547 1801 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1

Genomic Location for CEP85 Gene

Chromosome:
1
Start:
26,234,153 bp from pter
End:
26,279,038 bp from pter
Size:
44,886 bases
Orientation:
Plus strand

Genomic View for CEP85 Gene

Genes around CEP85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP85 Gene

Proteins for CEP85 Gene

  • Protein details for CEP85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2H3-CEP85_HUMAN
    Recommended name:
    Centrosomal protein of 85 kDa
    Protein Accession:
    Q6P2H3
    Secondary Accessions:
    • B4DRL1
    • D3DPK4
    • F8W7K4
    • Q5VY68
    • Q5VY70
    • Q9H6Q1
    • Q9H828
    • Q9UF52

    Protein attributes for CEP85 Gene

    Size:
    762 amino acids
    Molecular mass:
    85639 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15203.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP85 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP85 Gene

Post-translational modifications for CEP85 Gene

  • Ubiquitination at posLast=139139, posLast=178178, Lys357, Lys401, and posLast=633633
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP85 Gene

Domains & Families for CEP85 Gene

Protein Domains for CEP85 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP85 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P2H3

UniProtKB/Swiss-Prot:

CEP85_HUMAN :
  • Belongs to the CEP85 family.
Family:
  • Belongs to the CEP85 family.
genes like me logo Genes that share domains with CEP85: view

No data available for Gene Families for CEP85 Gene

Function for CEP85 Gene

Molecular function for CEP85 Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856).

Gene Ontology (GO) - Molecular Function for CEP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18985028
genes like me logo Genes that share ontologies with CEP85: view
genes like me logo Genes that share phenotypes with CEP85: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP85 Gene

Localization for CEP85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP85 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus, nucleolus. Note=Localizes to centrosomes and nucleolus in interphase. Upon entry into mitosis, relocates from nucleolus and accumulates at spindle poles (PubMed:21399614). Associated with the pericentriolar material. Localizes to centrosomes at a low level in G1 phase and a slightly increased level in S phase, with gradually elevated levels during G2 phase. The levels at centrosomes further increase at G2/M, reaching a peak at spindle poles at early mitotic stages and remain high until the end of anaphase (PubMed:26220856). {ECO:0000269 PubMed:21399614, ECO:0000269 PubMed:26220856}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP85 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
golgi apparatus 5

Gene Ontology (GO) - Cellular Components for CEP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IDA 26220856
GO:0000922 spindle pole IDA,IEA 21399614
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IDA,IEA 21399614
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CEP85: view

Pathways & Interactions for CEP85 Gene

SuperPathways for CEP85 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IMP 26220856
GO:0007059 chromosome segregation IEA --
GO:0046602 regulation of mitotic centrosome separation IMP 26220856
genes like me logo Genes that share ontologies with CEP85: view

No data available for Pathways by source and SIGNOR curated interactions for CEP85 Gene

Transcripts for CEP85 Gene

Unigene Clusters for CEP85 Gene

Centrosomal protein 85kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP85 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7: -
SP8:

Relevant External Links for CEP85 Gene

GeneLoc Exon Structure for
CEP85
ECgene alternative splicing isoforms for
CEP85

Expression for CEP85 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEP85 Gene

mRNA differential expression in normal tissues according to GTEx for CEP85 Gene

This gene is overexpressed in Muscle - Skeletal (x6.3).

Protein differential expression in normal tissues from HIPED for CEP85 Gene

This gene is overexpressed in Breast (52.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEP85 Gene



Protein tissue co-expression partners for CEP85 Gene

NURSA nuclear receptor signaling pathways regulating expression of CEP85 Gene:

CEP85

SOURCE GeneReport for Unigene cluster for CEP85 Gene:

Hs.63795

Evidence on tissue expression from TISSUES for CEP85 Gene

  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with CEP85: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP85 Gene

Orthologs for CEP85 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP85 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP85 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia CEP85 34 35
  • 91.27 (n)
cow
(Bos Taurus)
Mammalia CEP85 34 35
  • 90.51 (n)
mouse
(Mus musculus)
Mammalia Cep85 34 16 35
  • 86.16 (n)
rat
(Rattus norvegicus)
Mammalia Cep85 34
  • 84.94 (n)
oppossum
(Monodelphis domestica)
Mammalia CEP85 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP85 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP85 34 35
  • 66.14 (n)
lizard
(Anolis carolinensis)
Reptilia CEP85 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8231 34
zebrafish
(Danio rerio)
Actinopterygii si:ch211-11i5.2 34
  • 57.35 (n)
CEP85 35
  • 44 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for CEP85 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP85 Gene

ENSEMBL:
Gene Tree for CEP85 (if available)
TreeFam:
Gene Tree for CEP85 (if available)

Paralogs for CEP85 Gene

Paralogs for CEP85 Gene

(2) SIMAP similar genes for CEP85 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CEP85: view

Variants for CEP85 Gene

Sequence variations from dbSNP and Humsavar for CEP85 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000028397 -- 26,263,419(+) GGGCG(G/T)CTCAG intron-variant
rs1000048576 -- 26,274,528(+) CTGAT(C/T)TGCAG intron-variant
rs1000074565 -- 26,274,872(+) TGAGT(C/G)GTCAC intron-variant, downstream-variant-500B
rs1000188614 -- 26,238,874(+) AGGAG(G/T)GAGAA intron-variant
rs1000271208 -- 26,258,446(+) GCTAA(-/G)AACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP85 Gene

Variant ID Type Subtype PubMed ID
nsv473502 CNV novel sequence insertion 20440878

Variation tolerance for CEP85 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.49; 82.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP85 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP85

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP85 Gene

Disorders for CEP85 Gene

Relevant External Links for CEP85

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP85

No disorders were found for CEP85 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP85 Gene

Publications for CEP85 Gene

  1. Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction. (PMID: 26220856) Chen C. … Yu X. (J. Cell Sci. 2015) 3 4 64
  2. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L. … Andersen J.S. (EMBO J. 2011) 3 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for CEP85 Gene

Sources for CEP85 Gene

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