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Aliases for CEP85 Gene

Aliases for CEP85 Gene

  • Centrosomal Protein 85kDa 2 3
  • Coiled-Coil Domain-Containing Protein 21 3 4
  • CCDC21 3 4
  • Coiled-Coil Domain Containing 21 2
  • Centrosomal Protein Of 85 KDa 3
  • Cep85 4

External Ids for CEP85 Gene

Previous HGNC Symbols for CEP85 Gene

  • CCDC21

Previous GeneCards Identifiers for CEP85 Gene

  • GC01P026561

Summaries for CEP85 Gene

Entrez Gene Summary for CEP85 Gene

  • This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for CEP85 Gene

CEP85 (Centrosomal Protein 85kDa) is a Protein Coding gene. An important paralog of this gene is CEP85L.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP85 Gene

Genomics for CEP85 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CEP85 Gene

Start:
26,234,153 bp from pter
End:
26,279,038 bp from pter
Size:
44,886 bases
Orientation:
Plus strand

Genomic View for CEP85 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP85 Gene

No data available for Regulatory Elements for CEP85 Gene

Proteins for CEP85 Gene

  • Protein details for CEP85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P2H3-CEP85_HUMAN
    Recommended name:
    Centrosomal protein of 85 kDa
    Protein Accession:
    Q6P2H3
    Secondary Accessions:
    • B4DRL1
    • D3DPK4
    • F8W7K4
    • Q5VY68
    • Q5VY70
    • Q9H6Q1
    • Q9H828
    • Q9UF52

    Protein attributes for CEP85 Gene

    Size:
    762 amino acids
    Molecular mass:
    85639 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB15203.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP85 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP85 Gene

Proteomics data for CEP85 Gene at MOPED

Post-translational modifications for CEP85 Gene

  • Ubiquitination at Lys139, Lys178, Lys357, Lys401, and Lys633
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP85 Gene

No data available for DME Specific Peptides for CEP85 Gene

Domains for CEP85 Gene

Protein Domains for CEP85 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP85 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P2H3

UniProtKB/Swiss-Prot:

CEP85_HUMAN :
  • Q6P2H3
Family:
  • Belongs to the CEP85 family.
genes like me logo Genes that share domains with CEP85: view

No data available for Gene Families for CEP85 Gene

Function for CEP85 Gene

Gene Ontology (GO) - Molecular Function for CEP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18985028
genes like me logo Genes that share ontologies with CEP85: view

Phenotypes for CEP85 Gene

GenomeRNAi human phenotypes for CEP85:
genes like me logo Genes that share phenotypes with CEP85: view

Animal Model Products

CRISPR Products

miRNA for CEP85 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEP85 Gene

Localization for CEP85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP85 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Nucleus, nucleolus. Note=Localizes to centrosomes and nucleolus in interphase. Upon entry into mitosis, relocates from nucleolus and accumulates at spindle poles.

Gene Ontology (GO) - Cellular Components for CEP85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 21399614
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with CEP85: view

No data available for Subcellular locations from COMPARTMENTS for CEP85 Gene

Pathways for CEP85 Gene

SuperPathways for CEP85 Gene

No Data Available

Interacting Proteins for CEP85 Gene

Gene Ontology (GO) - Biological Process for CEP85 Gene

None

No data available for Pathways by source for CEP85 Gene

Transcripts for CEP85 Gene

Unigene Clusters for CEP85 Gene

Centrosomal protein 85kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP85

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP85 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7: -
SP8:

Relevant External Links for CEP85 Gene

GeneLoc Exon Structure for
CEP85
ECgene alternative splicing isoforms for
CEP85

Expression for CEP85 Gene

mRNA expression in normal human tissues for CEP85 Gene

mRNA differential expression in normal tissues according to GTEx for CEP85 Gene

This gene is overexpressed in Muscle - Skeletal (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP85 Gene

SOURCE GeneReport for Unigene cluster for CEP85 Gene Hs.63795

genes like me logo Genes that share expressions with CEP85: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CEP85 Gene

Orthologs for CEP85 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP85 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP85 35
  • 99.74 (n)
  • 99.74 (a)
CEP85 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEP85 35
  • 90.51 (n)
  • 89.2 (a)
CEP85 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP85 35
  • 91.27 (n)
  • 91.18 (a)
CEP85 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep85 35
  • 86.16 (n)
  • 85.55 (a)
Cep85 16
Cep85 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEP85 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP85 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep85 35
  • 84.94 (n)
  • 83.47 (a)
chicken
(Gallus gallus)
Aves CEP85 35
  • 66.14 (n)
  • 61.81 (a)
CEP85 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP85 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8231 35
zebrafish
(Danio rerio)
Actinopterygii CEP85 36
  • 44 (a)
OneToOne
si:ch211-11i5.2 35
  • 57.35 (n)
  • 50.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for CEP85:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP85 Gene

ENSEMBL:
Gene Tree for CEP85 (if available)
TreeFam:
Gene Tree for CEP85 (if available)

Paralogs for CEP85 Gene

Paralogs for CEP85 Gene

Selected SIMAP similar genes for CEP85 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CEP85: view

Variants for CEP85 Gene

Sequence variations from dbSNP and Humsavar for CEP85 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs869683 -- 26,244,502(+) AAATT(A/T)CTACT intron-variant
rs884533 -- 26,259,166(+) ttaaa(G/T)aattg intron-variant
rs1591467 -- 26,252,732(-) CACAC(A/G)TAACA intron-variant
rs1808046 -- 26,240,751(-) CACCC(A/G)GCTAA intron-variant
rs1889739 -- 26,255,662(-) AAACA(C/G)TGCCC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for CEP85 Gene

Variant ID Type Subtype PubMed ID
dgv201n71 CNV Gain 21882294

Relevant External Links for CEP85 Gene

HapMap Linkage Disequilibrium report
CEP85

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP85 Gene

Disorders for CEP85 Gene

No disorders were found for CEP85 Gene.

No data available for UniProtKB/Swiss-Prot for CEP85 Gene

Publications for CEP85 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L. … Andersen J.S. (EMBO J. 2011) 3 4

Products for CEP85 Gene

Sources for CEP85 Gene

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