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Aliases for CEP78 Gene

Aliases for CEP78 Gene

  • Centrosomal Protein 78 2 3
  • Centrosomal Protein 78kDa 2 3 5
  • C9orf81 3 4
  • Chromosome 9 Open Reading Frame 81 2
  • Cep78 4
  • IP63 3

External Ids for CEP78 Gene

Previous HGNC Symbols for CEP78 Gene

  • C9orf81

Previous GeneCards Identifiers for CEP78 Gene

  • GC09P078081
  • GC09P080040
  • GC09P080850
  • GC09P050682

Summaries for CEP78 Gene

GeneCards Summary for CEP78 Gene

CEP78 (Centrosomal Protein 78) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Organelle biogenesis and maintenance.

Gene Wiki entry for CEP78 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP78 Gene

Genomics for CEP78 Gene

Regulatory Elements for CEP78 Gene

Promoters for CEP78 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEP78 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEP78 Gene

Chromosome:
9
Start:
78,236,062 bp from pter
End:
78,279,690 bp from pter
Size:
43,629 bases
Orientation:
Plus strand

Genomic View for CEP78 Gene

Genes around CEP78 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP78 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP78 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP78 Gene

Proteins for CEP78 Gene

  • Protein details for CEP78 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JTW2-CEP78_HUMAN
    Recommended name:
    Centrosomal protein of 78 kDa
    Protein Accession:
    Q5JTW2
    Secondary Accessions:
    • A1A4S8
    • E9PHX5
    • Q5BJE3
    • Q5JTW0
    • Q5JTW1
    • Q9H9N3

    Protein attributes for CEP78 Gene

    Size:
    689 amino acids
    Molecular mass:
    76396 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH91515.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH91515.1; Type=Miscellaneous discrepancy; Note=Probable intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP78 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP78 Gene

Proteomics data for CEP78 Gene at MOPED

Post-translational modifications for CEP78 Gene

  • Ubiquitination at Lys 90, Lys 317, and Lys 374
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP78 Gene

No data available for DME Specific Peptides for CEP78 Gene

Domains & Families for CEP78 Gene

Protein Domains for CEP78 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP78 Gene

Graphical View of Domain Structure for InterPro Entry

Q5JTW2

UniProtKB/Swiss-Prot:

CEP78_HUMAN :
  • Belongs to the CEP78 family.
Family:
  • Belongs to the CEP78 family.
genes like me logo Genes that share domains with CEP78: view

No data available for Gene Families for CEP78 Gene

Function for CEP78 Gene

genes like me logo Genes that share phenotypes with CEP78: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP78 Gene

Localization for CEP78 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP78 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP78 Gene COMPARTMENTS Subcellular localization image for CEP78 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for CEP78 Gene

Pathways & Interactions for CEP78 Gene

genes like me logo Genes that share pathways with CEP78: view

Gene Ontology (GO) - Biological Process for CEP78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with CEP78: view

No data available for SIGNOR curated interactions for CEP78 Gene

Drugs & Compounds for CEP78 Gene

No Compound Related Data Available

Transcripts for CEP78 Gene

Unigene Clusters for CEP78 Gene

Centrosomal protein 78kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP78 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ·
SP1: - - - -
SP2: - - -
SP3:
SP4: -
SP5: -
SP6:
SP7: - - - - - - - - - - - - - - - - - - - - -

ExUns: 16d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for CEP78 Gene

GeneLoc Exon Structure for
CEP78
ECgene alternative splicing isoforms for
CEP78

Expression for CEP78 Gene

mRNA expression in normal human tissues for CEP78 Gene

Protein differential expression in normal tissues from HIPED for CEP78 Gene

This gene is overexpressed in Testis (28.4), Peripheral blood mononuclear cells (23.5), and CD8 Tcells (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP78 Gene



SOURCE GeneReport for Unigene cluster for CEP78 Gene Hs.374421

genes like me logo Genes that share expression patterns with CEP78: view

Protein tissue co-expression partners for CEP78 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP78 Gene

Orthologs for CEP78 Gene

This gene was present in the common ancestor of animals.

Orthologs for CEP78 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP78 35
  • 99.35 (n)
  • 99.19 (a)
CEP78 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEP78 36
  • 75 (a)
OneToOne
CEP78 35
  • 88.73 (n)
  • 85.73 (a)
dog
(Canis familiaris)
Mammalia CEP78 35
  • 89.1 (n)
  • 87.4 (a)
CEP78 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep78 16
Cep78 35
  • 81.53 (n)
  • 79.69 (a)
Cep78 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CEP78 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep78 35
  • 82.17 (n)
  • 79.23 (a)
chicken
(Gallus gallus)
Aves CEP78 35
  • 66.16 (n)
  • 63.04 (a)
CEP78 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP78 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep78 35
  • 62.63 (n)
  • 60.71 (a)
Str.11363 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2778 35
zebrafish
(Danio rerio)
Actinopterygii cep78 36
  • 44 (a)
OneToOne
cep78 35
  • 56.77 (n)
  • 53.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7886 36
  • 18 (a)
OneToOne
Species with no ortholog for CEP78:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP78 Gene

ENSEMBL:
Gene Tree for CEP78 (if available)
TreeFam:
Gene Tree for CEP78 (if available)

Paralogs for CEP78 Gene

No data available for Paralogs for CEP78 Gene

Variants for CEP78 Gene

Sequence variations from dbSNP and Humsavar for CEP78 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs928390 -- 78,239,363(+) ATGCC(C/T)ACGCA intron-variant
rs1929402 -- 78,248,172(+) ATTAT(A/G)TGGAA intron-variant
rs1065334 -- 78,266,855(+) AAATA(C/T)GTTTC intron-variant, utr-variant-3-prime
rs7020215 -- 78,264,973(+) TTGGT(A/G)AGGAA intron-variant
rs7021098 -- 78,252,675(+) GCTTA(A/G)GAAAA intron-variant

Variation tolerance for CEP78 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP78 Gene

HapMap Linkage Disequilibrium report
CEP78

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CEP78 Gene

Disorders for CEP78 Gene

Relevant External Links for CEP78

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP78

No disorders were found for CEP78 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP78 Gene

Publications for CEP78 Gene

  1. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen J.S. … Mann M. (Nature 2003) 2 3 4 67
  2. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3

Products for CEP78 Gene

Sources for CEP78 Gene

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