CEP76 Gene
protein-coding GIFtS: 47
GCID: GC18M012734
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centrosomal protein 76kDa(Previous name: chromosome 18 open reading frame 9 )
(Previous symbol: C18orf9)
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Aliases
for CEP76 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Centrosomal Protein 76kDa1 2 | | Chromosome 18 Open Reading Frame 91 | | C18orf91 2 3 | | Centrosomal Protein Of 76 KDa2 | | HsT17051 2 | | Cep763 | | FLJ125421 | | |
Export aliases for CEP76 gene to outside databasesPrevious GC identifer: GC18M012663 |
Summaries
for CEP76 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CEP76:
This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication toonce per cell cycle. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Dec 2012)
UniProtKB/Swiss-Prot: CEP76_HUMAN, Q8TAP6Function: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplicationto once per cell cycle by preventing centriole reduplication
Gene Wiki entry for CEP76
|
Genomic Views
for CEP76 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CEP76 gene promoter:
TBP oct-B3 oct-B2 HOXA3 Tal-1 POU2F2 YY1 E47 POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for CEP76
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP76 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.21 Ensembl cytogenetic band: 18p11.21 HGNC cytogenetic band: 18p11.21CEP76 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M012734: view genomic region
(about GC identifiers)
Start:
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12,661,832 bp from pter |
End:
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12,702,776 bp from pter |
Size:
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40,945 bases |
Orientation:
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minus strand |
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Proteins
for CEP76 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CEP76_HUMAN, Q8TAP6 (See
protein sequence)Recommended Name: Centrosomal protein of 76 kDa Size: 659 amino acids; 74413 Da
Subunit: Interacts with CEP110/CP110 and CEP97
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, centrosome, centriole. Note=Doesnot localize along the ciliary axoneme
Developmental stage: Expressed at low level in G1 and is induced in S and G2 phase, during which point centrioles havealready commenced duplication (at protein level)
Sequence caution: Sequence=BAG64223.1; Type=Erroneous termination; Positions=648; Note=Translated as Trp;
Secondary accessions: B0YJB2 B4DXG5 B4DZW1 Q658N5 Q9H9U7Alternative splicing: 3 isoforms: Q8TAP6-1 Q8TAP6-2 Q8TAP6-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CEP76: NX_Q8TAP6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TAP6
CEP76 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001258918.1 NP_079175.2
ENSEMBL proteins: ENSP00000464760 ENSP00000262127 ENSP00000403074 ENSP00000464911 ENSP00000466689 ENSP00000467361 ENSP00000467224 ENSP00000466833 Reactome Protein details: Q8TAP6
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CEP76 for ontologies About GeneDecksing
CEP76 Antibody Products:
Assay Products for CEP76: |
Protein
Domains /
Families
for CEP76 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8TAP6 UniProtKB/Swiss-Prot: CEP76_HUMAN, Q8TAP6Similarity: Belongs to the CEP76 family |
Function
for CEP76 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CEP76_HUMAN, Q8TAP6Function: Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplicationto once per cell cycle by preventing centriole reduplication
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP76 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP76
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP76 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
CEP76 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CEP76:
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Pathways & Interactions
for CEP76 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Recruitment of mitotic centrosome proteins and complexes | | | 2 | Cell Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/8 
Reactome Pathways for CEP76 (see all 8)
CEP76 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEP76
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/72 Interacting proteins for CEP76 (Q8TAP62, 3 ENSP000002621274) via UniProtKB, MINT, STRING, and/or I2D (see all 72)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
CEP76 for ontologies About GeneDecksing
|
Drugs & Compounds
for CEP76 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CEP76
Search CenterWatch for drugs/clinical trials and news about CEP76
|
Transcripts
for CEP76 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CEP76 gene (2 alternative transcripts): NM_001271989.1 NM_024899.3 Unigene Cluster for CEP76: Centrosomal protein 76kDa Hs.236940 [show with all ESTs]Unigene Representative Sequence: AL83372712 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000590143 ENST00000262127(uc002krh.3 uc002kri.3 uc010wzz.2 uc010xaa.1 uc010xab.1)
ENST00000423709 ENST00000589490 ENST00000587666 ENST00000593250 ENST00000591034
ENST00000585751 ENST00000592660 ENST00000589875 ENST00000587929 ENST00000586887
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP76 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP76
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CEP76 (NM_024899) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEP76 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP76 |
Additional cDNA sequence: AK022604.1 AK298223.1 AK301964.1 AK303117.1 AL833727.1 BC026307.1 BC033026.1 NR_073537.1 10 DOTS entries: DT.410878 DT.454748 DT.91737180 DT.95148704 DT.100743104 DT.86852747 DT.121092388 DT.40111236 DT.95265103 DT.87018200 24/80 AceView cDNA sequences (see all 80): AI953683 BE144878 AA403222 BM850707 AA974323 BM982825 BQ959361 AK022604 BQ232035 AW519095 AA609857 BI869538 AA491275 AA482139 NM_024899 BC026307 BX119812 BU633640 AU124775 BE182953 AI184141 BQ894919 BM753482 BU171480
GeneLoc Exon Structure
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Expression
for CEP76 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CEP76 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CEP76 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEP76
SOURCE GeneReport for Unigene cluster: Hs.236940
SABiosciences Custom PCR Arrays for CEP76
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP76
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CEP76 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP76 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP76 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP76 |
Orthologs
for CEP76 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CEP76 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for CEP76 (if available)
TreeFam Gene Tree for CEP76 (if available) |
Paralogs
for CEP76 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CEP76 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP76 |
|
Disorders
/ Diseases
for CEP76 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CEP76 for disorders About GeneDecksing
3  diseases for CEP76: About MalaCardsanonychia congenita ataxia malaria
1 disease from the University of Copenhagen DISEASES database for CEP76:Nail disease Export disorders for CEP76 gene to outside databases
|
Publications
for CEP76 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CEP76 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with CEP76) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843)1, 2, 3 Andersen J.S....Mann M. (2003)
- Cep76, a centrosomal protein that specifically restrains centriole reduplication. (PubMed id 19460342)1, 2, 9 Tsang W.Y.... Dynlacht B.D. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PubMed id 22261722)1 Al-Hakim A.K....Pelletier L. (2012)
- Neurl4, a novel daughter centriole protein, prevents f ormation of ectopic microtubule organizing centres. (PubMed id 22441691)1 Li J....Dynlacht B.D. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
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External Searches for CEP76 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CEP76 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CEP76 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CEP76 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CEP76 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CEP76 gene:
Search GeneIP for patents involving CEP76
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CEP76 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CEP76 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEP76 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP76 | | | OriGene Protein Over-expression Lysate for CEP76 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CEP76 | | OriGene 3'-UTR Clone for CEP76 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP76 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP76 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CEP76 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CEP76 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP76 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP76 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEP76 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP76 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP76 |
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 | | | CEP76 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP76 |
|  |  |  | | | | ThermoFisher Antibodies for CEP76 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP76 |
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