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Aliases for CEP72 Gene

Aliases for CEP72 Gene

  • Centrosomal Protein 72kDa 2 3
  • KIAA1519 4
  • Cep72 4

External Ids for CEP72 Gene

Previous GeneCards Identifiers for CEP72 Gene

  • GC05P000667

Summaries for CEP72 Gene

Entrez Gene Summary for CEP72 Gene

  • The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for CEP72 Gene

CEP72 (Centrosomal Protein 72kDa) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include identical protein binding. An important paralog of this gene is LRRC36.

UniProtKB/Swiss-Prot for CEP72 Gene

  • Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs).

Gene Wiki entry for CEP72 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP72 Gene

Genomics for CEP72 Gene

Regulatory Elements for CEP72 Gene

Genomic Location for CEP72 Gene

Start:
612,272 bp from pter
End:
667,168 bp from pter
Size:
54,897 bases
Orientation:
Plus strand

Genomic View for CEP72 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP72 Gene

Proteins for CEP72 Gene

  • Protein details for CEP72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P209-CEP72_HUMAN
    Recommended name:
    Centrosomal protein of 72 kDa
    Protein Accession:
    Q9P209
    Secondary Accessions:
    • B4DR26
    • Q9BV03
    • Q9BWM3
    • Q9NVR4

    Protein attributes for CEP72 Gene

    Size:
    647 amino acids
    Molecular mass:
    71718 Da
    Quaternary structure:
    • Interacts with KIZ.
    SequenceCaution:
    • Sequence=BAA91685.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96043.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP72 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP72 Gene

Proteomics data for CEP72 Gene at MOPED

Post-translational modifications for CEP72 Gene

  • Ubiquitination at Lys115
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP72 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CEP72 Gene

Domains for CEP72 Gene

Protein Domains for CEP72 Gene

Suggested Antigen Peptide Sequences for CEP72 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P209

UniProtKB/Swiss-Prot:

CEP72_HUMAN :
  • Q9P209
Domain:
  • Contains 1 LRRCT domain.
Family:
  • Belongs to the CEP72 family.
Similarity:
  • Contains 3 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with CEP72: view

No data available for Gene Families for CEP72 Gene

Function for CEP72 Gene

Molecular function for CEP72 Gene

UniProtKB/Swiss-Prot Function: Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs).

Gene Ontology (GO) - Molecular Function for CEP72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19536135
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with CEP72: view

miRNA for CEP72 Gene

miRTarBase miRNAs that target CEP72

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEP72 Gene

Localization for CEP72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP72 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP72 Gene COMPARTMENTS Subcellular localization image for CEP72 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CEP72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 19536135
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CEP72: view

Pathways for CEP72 Gene

genes like me logo Genes that share pathways with CEP72: view

Gene Ontology (GO) - Biological Process for CEP72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
GO:0007051 spindle organization IMP 19536135
GO:0033566 gamma-tubulin complex localization IMP 19536135
genes like me logo Genes that share ontologies with CEP72: view

Transcripts for CEP72 Gene

Unigene Clusters for CEP72 Gene

Centrosomal protein 72kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP72 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - -
SP2: - - -
SP3:
SP4:
SP5:

Relevant External Links for CEP72 Gene

GeneLoc Exon Structure for
CEP72
ECgene alternative splicing isoforms for
CEP72

Expression for CEP72 Gene

mRNA expression in normal human tissues for CEP72 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP72 Gene

SOURCE GeneReport for Unigene cluster for CEP72 Gene Hs.591741

genes like me logo Genes that share expressions with CEP72: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP72 Gene

Orthologs for CEP72 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP72 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP72 35
  • 98.31 (n)
  • 97.62 (a)
CEP72 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEP72 35
  • 75.64 (n)
  • 68.14 (a)
CEP72 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP72 35
  • 76.92 (n)
  • 70.23 (a)
CEP72 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep72 35
  • 73.58 (n)
  • 67.55 (a)
Cep72 16
Cep72 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEP72 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP72 36
  • 48 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep72 35
  • 74.15 (n)
  • 67.08 (a)
lizard
(Anolis carolinensis)
Reptilia CEP72 36
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cep72 36
  • 27 (a)
OneToOne
Species with no ortholog for CEP72:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP72 Gene

ENSEMBL:
Gene Tree for CEP72 (if available)
TreeFam:
Gene Tree for CEP72 (if available)

Paralogs for CEP72 Gene

Paralogs for CEP72 Gene

genes like me logo Genes that share paralogs with CEP72: view

Variants for CEP72 Gene

Sequence variations from dbSNP and Humsavar for CEP72 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs868648 -- 640,767(-) AGGCC(A/G)CGTTC intron-variant
rs868649 - 640,590(-) GTGTG(C/T)GTGGT reference, missense
rs869955 - 635,393(-) ACTGC(A/G)GGCTC reference, missense
rs870571 -- 634,660(+) CTGGC(C/T)GTGCC intron-variant
rs905193 -- 634,980(-) AGGCA(A/G)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP72 Gene

Variant ID Type Subtype PubMed ID
esv2752071 CNV Gain 17911159
nsv880710 CNV Loss 21882294
dgv5883n71 CNV Gain 21882294
dgv5884n71 CNV Gain 21882294
nsv881305 CNV Loss 21882294
nsv509042 CNV Insertion 20534489
nsv881103 CNV Gain 21882294
nsv830185 CNV Gain 17160897
dgv685n27 CNV Gain 19166990
dgv5892n71 CNV Gain 21882294
dgv5893n71 CNV Gain 21882294
nsv510933 CNV Complex 20534489
nsv461893 CNV Loss 19166990
nsv461894 CNV Gain 19166990
nsv525620 CNV Gain 19592680
dgv5n29 CNV Gain 16826518
nsv471627 CNV Gain+Loss 15918152
esv2666809 CNV Deletion 23128226
dgv1735e1 CNV Complex 17122850
dgv1736e1 CNV Complex 17122850
nsv428459 CNV Gain+Loss 18775914
esv2729333 CNV Deletion 23290073
esv24755 CNV Gain+Loss 19812545
nsv822928 CNV Loss 20364138
esv1229549 CNV Insertion 17803354
esv1293034 CNV Insertion 17803354
esv1064367 CNV Insertion 17803354
nsv327941 CNV Loss 16902084
nsv329867 CNV Insertion 16902084
nsv821539 CNV Deletion 20802225
esv2729334 CNV Deletion 23290073
esv1250929 CNV Insertion 17803354
nsv328511 CNV Loss 16902084
esv2729335 CNV Deletion 23290073
nsv10652 CNV Loss 18304495
esv2729336 CNV Deletion 23290073
nsv881247 CNV Gain 21882294
esv1512084 CNV Insertion 17803354
esv1280202 CNV Insertion 17803354
esv2656973 CNV Deletion 23128226
esv2729337 CNV Deletion 23290073
esv1630106 CNV Deletion 17803354
essv13335 CNV CNV 17122850
dgv1737e1 CNV Complex 17122850
esv1003099 CNV Deletion 20482838
esv25844 CNV Loss 19812545
esv2729338 CNV Deletion 23290073
nsv10653 CNV Loss 18304495
esv988499 CNV Loss 20482838
esv1926133 CNV Deletion 18987734
esv2729340 CNV Deletion 23290073
dgv954e201 CNV Deletion 23290073
esv2729342 CNV Deletion 23290073
esv2729343 CNV Deletion 23290073
nsv327962 CNV Loss 16902084
esv1785686 CNV Deletion 17803354
nsv328227 CNV Loss 16902084
esv2729345 CNV Deletion 23290073
esv1645370 CNV Insertion 17803354
nsv513208 CNV Loss 21212237
nsv329670 CNV Loss 16902084
esv2729346 CNV Deletion 23290073
esv1560788 CNV Deletion 17803354
esv1436922 CNV Deletion 17803354
esv1218667 CNV Deletion 17803354
nsv822929 CNV Loss 20364138
dgv5894n71 CNV Gain+Loss 21882294

Relevant External Links for CEP72 Gene

HapMap Linkage Disequilibrium report
CEP72

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP72 Gene

Disorders for CEP72 Gene

Relevant External Links for CEP72

Genetic Association Database (GAD)
CEP72
Human Genome Epidemiology (HuGE) Navigator
CEP72
genes like me logo Genes that share disorders with CEP72: view

No data available for UniProtKB/Swiss-Prot for CEP72 Gene

Publications for CEP72 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  3. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen J.S. … Mann M. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CEP72 Gene

Sources for CEP72 Gene

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