Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CEP72 Gene

protein-coding GIFtS: 52
GCID: GC05P000612

centrosomal protein 72kDa

Explore 4 diseases affiliated with
CEP72 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Centrosomal Protein 72kDa¹ ²
KIAA1519¹ ³
FLJ10565¹
Centrosomal Protein Of 72 KDa²
Cep72³

External Ids:	HGNC: 25547¹	Entrez Gene: 55722²	Ensembl: ENSG00000112877⁷	UniProtKB: Q9P209³

Export aliases for CEP72 gene to outside databases

Previous GC identifer: GC05P000667

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CEP72:

The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized

to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal

cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CEP72_HUMAN, Q9P209

Function: Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal

microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a

focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for

localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs)

Gene Wiki entry for CEP72

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006576.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CEP72 gene promoter:
c-Fos Sox5 AP-1 Fra-1 FosB Evi-1 PPAR-gamma1 PPAR-gamma2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CEP72 promoter sequence

Search SABiosciences Chromatin IP Primers for CEP72

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP72

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.33 Ensembl cytogenetic band: 5p15.33 HGNC cytogenetic band: 5p15.33

CEP72 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP72 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P000612: view genomic region (about GC identifiers)

Start:	612,387 bp from pter	End:	667,283 bp from pter
Size:	54,897 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CEP72_HUMAN, Q9P209 (See protein sequence)

Recommended Name: Centrosomal protein of 72 kDa

Size: 647 amino acids; 71718 Da

Subunit: Interacts with KIZ/PLK1S1

Subcellular location: Cytoplasm, cytoskeleton, centrosome. Note=Localizes to the centrosome and centrosome-surrounding

particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole,

suggesting that CEP72-associating particles localize in a microtubule-dependent manner

Sequence caution: Sequence=BAA91685.1; Type=Erroneous initiation; Sequence=BAA96043.1; Type=Erroneous initiation;

Secondary accessions: B4DR26 Q9BV03 Q9BWM3 Q9NVR4

Alternative splicing: 2 isoforms: Q9P209-1 Q9P209-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CEP72: NX_Q9P209

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9P209

CEP72 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060610.2

ENSEMBL proteins:

ENSP00000264935 ENSP00000392052

Reactome Protein details: Q9P209
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: CEP72 OriGene Custom Protein Services for CEP72
	GenScript Custom Purified and Recombinant Proteins Services for CEP72
	Novus Biologicals CEP72 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CEP72

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005813	centrosome	IDA	--
GO:0005829	cytosol	TAS	--

CEP72 for ontologies About GeneDecksing

CEP72 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CEP72
	GenScript Custom Superior Antibodies Services for CEP72
	Novus Biologicals CEP72 Antibodies
	Search for Antibodies for CEP72 at Abcam
	Uscn Antibodies for CEP72
	Search ThermoFisher Antibodies for CEP72

Assay Products for CEP72:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CEP72
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CEP72

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CEP72 for domains About GeneDecksing

3 InterPro domains/families:

IPR001611 Leu-rich_rpt

IPR025875 Leu-rich_rpt_4

IPR003603 U2A'_phosphoprotein32A_C

Graphical View of Domain Structure for InterPro Entry Q9P209

ProtoNet protein and cluster: Q9P209

UniProtKB/Swiss-Prot: CEP72_HUMAN, Q9P209

Similarity: Belongs to the CEP72 family

Similarity: Contains 3 LRR (leucine-rich) repeats

Similarity: Contains 1 LRRCT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CEP72_HUMAN, Q9P209

Function: Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal

microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a

focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for

localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs)

miRNA Products:		miRTarBase miRNAs that target CEP72: hsa-mir-30a (MIRT005189)

		OriGene 3'-UTR Clone: CEP72 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEP72
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CEP72
		SwitchGear 3'UTR luciferase reporter plasmid: CEP72 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEP72 (see all 4) OriGene shRNA RFP: CEP72 OriGene siRNA: CEP72
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEP72

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CEP72

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP72 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP72 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CEP72 (NM_018140)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEP72
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP72

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CEP72
		Search LifeMap BioReagents cell lines for CEP72

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP72

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0042802	identical protein binding	IEA	--

CEP72 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Recruitment of mitotic centrosome proteins and complexes

Centrosome maturation	1.00	Mitotic G2-G2/M phases	0.81
Recruitment of mitotic centrosome proteins and complexes	1.00	Loss of proteins required for interphase microtubule organizationÂ from the centrosome	0.78
G2/M Transition	0.83	Loss of Nlp from mitotic centrosomes	0.78

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 Reactome Pathways for CEP72 (see all 8)

	Centrosome maturation
	Cell Cycle
	Recruitment of mitotic centrosome proteins and complexes
	G2/M Transition
	Loss of proteins required for interphase microtubule organizationÂ from the centrosome

CEP72 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CEP72

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/77 Interacting proteins for CEP72 (Q9P209^{1, 2, 3} ENSP00000264935⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 77)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLK1S1	Q2M2Z5²^,³	MINT-7298066 MINT-7298084 MINT-7298075 I2D: score=1
LNX1	Q8TBB1²^,³, ENSP00000263925⁴	MINT-67141 I2D: score=5 STRING: ENSP00000263925
ZBTB16	Q05516²^,³, ENSP00000338157⁴	MINT-66632 I2D: score=5 STRING: ENSP00000338157
ZNF417	Q8TAU3²^,³, ENSP00000311319⁴	MINT-67447 I2D: score=4 STRING: ENSP00000311319
KIAA0408	Q6ZU52²^,³	MINT-66023 I2D: score=5

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0007051	spindle organization	IMP	19536135
GO:0033566	gamma-tubulin complex localization	IMP	19536135

CEP72 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CEP72
Search CenterWatch for drugs/clinical trials and news about CEP72

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CEP72 gene:

NM_018140.3

Unigene Cluster for CEP72:

Centrosomal protein 72kDa

Hs.591741 [show with all ESTs]

Unigene Representative Sequence: NM_018140

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000264935(uc003jbf.3) ENST00000512038 ENST00000499639 ENST00000514507

ENST00000444221(uc011clz.1)

miRNA Products:		OriGene 3'-UTR Clone: CEP72 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEP72
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CEP72
		SwitchGear 3'UTR luciferase reporter plasmid: CEP72 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEP72 (see all 4) OriGene shRNA RFP: CEP72 OriGene siRNA: CEP72
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEP72

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP72 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP72 (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CEP72 (NM_018140)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEP72
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP72

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP72 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat CEP72
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP72
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP72

Additional cDNA sequence:

AB040952.1 AK001427.1 AK299072.1 BC000132.2 BC001750.1

2 DOTS entries:

DT.40119990 DT.95297425

24/60 AceView cDNA sequences (see all 60):

NM_018140 BM128194 BC001750 BP350496 AI739508 AW291219 AK001427 AW675487

BP376675 AI308771 BC000132 CK819219 AL043475 BP350529 AW294741 AI739509

BM688848 AI280589 BE502337 AB040952 BQ771509 BG822232 BX952752 AI864389

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CEP72 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15a	·	15b
SP1:					-		-																								-
SP2:					-		-								-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for CEP72

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CEP72 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTCAGACA

About this image

CEP72 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CEP72 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEP72

SOURCE GeneReport for Unigene cluster: Hs.591741

SABiosciences Custom PCR Arrays for CEP72

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP72 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat CEP72
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP72
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP72

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP72

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CEP72 gene from 2/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cep72^{1 , 5}	centrosomal protein 72^{1, 5}	73.74(n)¹ 67.55(a)¹		13 (40.15 cM)⁵ 74470¹ NM_028959.3¹ NP_083235.3¹ 74036495⁵
zebrafish (Danio rerio)	Actinopterygii	cep72¹	centrosomal protein 72	50.05(n) 37.26(a)		553488 XM_002667722.2 XP_002667768.2

ENSEMBL Gene Tree for CEP72 (if available)
TreeFam Gene Tree for CEP72 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CEP72 gene

LRRC36²

CEP72 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs924608^1,2	C,F,A,H,	--	610537(+)	`CACACC/ACCCCC`	1	--	us2k¹		10		NS EA WA NA CSA	776
rs78146255^1,2	C,	--	610681(+)	`TCACAC/TACCAT`	1	--	us2k¹		4		WA NA EA	360
rs146551934^1,2		--	610699(+)	`TCCTGC/GACACA`	1	--	us2k¹		0	--	--	--	--
rs185671295^1,2		--	610867(+)	`TACCTC/GCTGCA`	1	--	us2k¹		0	--	--	--	--
rs190496223^1,2		--	611060(+)	`CACACA/CCCTCC`	1	--	us2k¹		0	--	--	--	--
rs73044893^1,2	C,F,	--	611102(+)	`AGACCC/GTGCAC`	1	--	us2k¹		4		WA NA	242
rs141551900^1,2		--	611168(+)	`CCCCTA/GCATAC`	1	--	us2k¹		0	--	--	--	--
rs150392979^1,2		--	611193(+)	`ACTGCA/GCATAC`	1	--	us2k¹		0	--	--	--	--
rs2335953^1,2	C,F,H,	--	611254(-)	`GTGTGC/TAGACA`	1	--	us2k¹		4		NS NA	578
rs149938398^1,2	C,	--	611386(+)	`CACAC-/CCCCT ACACACTCCCCT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CEP72 (612387 - 667283 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 31 variations for CEP72
15/20 CNVs (see all 20): 2564 2078 0705 32691 2077 4428 53290 92791 3537 68938 8476 0706 68939 2079 92792
11 Indels: 27991 27989 92793 12636 68937 12635 27988 46914 33781 80758 27992

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP72

DNA2.0 Custom Variant and Variant Library Synthesis for CEP72

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CEP72 for disorders About GeneDecksing

4 diseases for CEP72: About MalaCards

macular degeneration rheumatoid arthritis arthritis ataxia

Human Genome Epidemiology (HuGE) Navigator: CEP72 (2 documents)

Export disorders for CEP72 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CEP72 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with CEP72)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2, 3} Nagase T.... Ohara O. (2000)
Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation. (PubMed id 19536135)^{1, 2} Oshimori N.... Yamamoto T. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843)^{1, 2} Andersen J.S....Mann M. (2003)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)¹ Kahle J.J....Zoghbi H.Y. (2011)
Genome-wide association identifies multiple ulcerativ e colitis susceptibility loci. (PubMed id 20228799)¹ McGovern D.P....Weersma R.K. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55722	HGNC: 25547	AceView: Cep72	Ensembl:ENSG00000112877	euGenes: HUgn55722
ECgene: CEP72	H-InvDB: CEP72

(According to HUGE)
About This Section

HUGE: KIAA1519

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CEP72	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CEP72 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CEP72 gene:
Search GeneIP for patents involving CEP72

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CEP72
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEP72		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP72
	OriGene Protein Over-expression Lysate for CEP72		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CEP72		OriGene 3'-UTR Clone for CEP72
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP72		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP72
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CEP72		OriGene Custom Protein Services for CEP72
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CEP72
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP72
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP72
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEP72
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP72
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP72

	GenScript Custom Purified and Recombinant Proteins Services for CEP72		GenScript cDNA clones with any tag delivered in your preferred vector for CEP72
	GenScript Custom Assay Services for CEP72		GenScript Custom Superior Antibodies Services for CEP72
	GenScript Custom overexpressing Cell Line Services for CEP72		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CEP72 promoter
	Search Chromatin IP Primers for CEP72
	Search RT² qPCR Primer Assays in human, mouse, rat CEP72
	Search GNC Networks for CEP72
	SABiosciences Custom PCR Arrays for CEP72

Search Tocris compounds for CEP72

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CEP72 antibodies
	CEP72 lysates

	Search for Antibodies for CEP72 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CEP72
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CEP72 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CEP72

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP72

	SwitchGear 3'UTR luciferase reporter plasmids for CEP72
	SwitchGear Promoter luciferase reporter plasmids for CEP72

Search ThermoFisher Antibodies for CEP72

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP72

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CEP72 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CEP72 Gene

centrosomal protein 72kDa

Aliases
for CEP72 gene

Summaries
for CEP72 gene

Genomic Views
for CEP72 gene

Proteins
for CEP72 gene

Protein Domains /
Families
for CEP72 gene

Function
for CEP72 gene

Pathways & Interactions
for CEP72 gene

Drugs & Compounds
for CEP72 gene

Transcripts
for CEP72 gene

Expression
for CEP72 gene

Orthologs
for CEP72 gene

Paralogs
for CEP72 gene

Genomic Variants
for CEP72 gene

Disorders / Diseases
for CEP72 gene

Publications
for CEP72 gene

External Searches for CEP72 gene

Genome Databases showing CEP72 gene

Other Databases showing CEP72 gene

Specialized Databases showing CEP72 gene

Intellectual Property
for CEP72 gene

Products
for CEP72 gene

View Random Gene

Advanced Search

Export list of displayed genes

CEP72 Gene

centrosomal protein 72kDa

Aliasesfor CEP72 gene

Summariesfor CEP72 gene

Genomic Viewsfor CEP72 gene

Proteinsfor CEP72 gene

Protein Domains /Familiesfor CEP72 gene

Functionfor CEP72 gene

Pathways & Interactionsfor CEP72 gene

Drugs & Compoundsfor CEP72 gene

Transcriptsfor CEP72 gene

Expression for CEP72 gene

Orthologsfor CEP72 gene

Paralogsfor CEP72 gene

Genomic Variantsfor CEP72 gene

Disorders / Diseasesfor CEP72 gene

Publicationsfor CEP72 gene

External Searches for CEP72 gene

Genome Databases showing CEP72 gene

Other Databases showing CEP72 gene

Specialized Databases showing CEP72 gene

Intellectual Propertyfor CEP72 gene

Productsfor CEP72 gene

View Random Gene

Aliases
for CEP72 gene

Summaries
for CEP72 gene

Genomic Views
for CEP72 gene

Proteins
for CEP72 gene

Protein Domains /
Families
for CEP72 gene

Function
for CEP72 gene

Pathways & Interactions
for CEP72 gene

Drugs & Compounds
for CEP72 gene

Transcripts
for CEP72 gene

Expression
for CEP72 gene

Orthologs
for CEP72 gene

Paralogs
for CEP72 gene

Genomic Variants
for CEP72 gene

Disorders / Diseases
for CEP72 gene

Publications
for CEP72 gene

Intellectual Property
for CEP72 gene

Products
for CEP72 gene