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Aliases for CEP72 Gene

Aliases for CEP72 Gene

  • Centrosomal Protein 72 2 3
  • Centrosomal Protein 72kDa 2 5
  • KIAA1519 4
  • Cep72 4

External Ids for CEP72 Gene

Previous GeneCards Identifiers for CEP72 Gene

  • GC05P000667

Summaries for CEP72 Gene

Entrez Gene Summary for CEP72 Gene

  • The product of this gene is a member of the leucine-rich-repeat (LRR) superfamily of proteins. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for CEP72 Gene

CEP72 (Centrosomal Protein 72) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include identical protein binding. An important paralog of this gene is LRRC36.

UniProtKB/Swiss-Prot for CEP72 Gene

  • Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).

Gene Wiki entry for CEP72 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP72 Gene

Genomics for CEP72 Gene

Regulatory Elements for CEP72 Gene

Enhancers for CEP72 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CEP72 on UCSC Golden Path with GeneCards custom track

Promoters for CEP72 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEP72 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEP72 Gene

Chromosome:
5
Start:
612,272 bp from pter
End:
667,168 bp from pter
Size:
54,897 bases
Orientation:
Plus strand

Genomic View for CEP72 Gene

Genes around CEP72 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP72 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP72 Gene

Proteins for CEP72 Gene

  • Protein details for CEP72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P209-CEP72_HUMAN
    Recommended name:
    Centrosomal protein of 72 kDa
    Protein Accession:
    Q9P209
    Secondary Accessions:
    • B4DR26
    • Q9BV03
    • Q9BWM3
    • Q9NVR4

    Protein attributes for CEP72 Gene

    Size:
    647 amino acids
    Molecular mass:
    71718 Da
    Quaternary structure:
    • Interacts with KIZ, PCM1 and CDK5RAP2.
    SequenceCaution:
    • Sequence=BAA91685.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA96043.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP72 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP72 Gene

Proteomics data for CEP72 Gene at MOPED

Post-translational modifications for CEP72 Gene

  • Ubiquitination at Lys 115
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP72 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEP72 Gene

Domains & Families for CEP72 Gene

Protein Domains for CEP72 Gene

Suggested Antigen Peptide Sequences for CEP72 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P209

UniProtKB/Swiss-Prot:

CEP72_HUMAN :
  • Contains 1 LRRCT domain.
  • Belongs to the CEP72 family.
  • Contains 3 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
Family:
  • Belongs to the CEP72 family.
Similarity:
  • Contains 3 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with CEP72: view

No data available for Gene Families for CEP72 Gene

Function for CEP72 Gene

Molecular function for CEP72 Gene

UniProtKB/Swiss-Prot Function:
Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (PubMed:19536135). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806).
genes like me logo Genes that share phenotypes with CEP72: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP72 Gene

Localization for CEP72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP72 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP72 Gene COMPARTMENTS Subcellular localization image for CEP72 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CEP72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034451 centriolar satellite IDA 26297806
genes like me logo Genes that share ontologies with CEP72: view

Pathways & Interactions for CEP72 Gene

genes like me logo Genes that share pathways with CEP72: view

Gene Ontology (GO) - Biological Process for CEP72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
GO:0033566 gamma-tubulin complex localization IMP 19536135
genes like me logo Genes that share ontologies with CEP72: view

No data available for SIGNOR curated interactions for CEP72 Gene

Drugs & Compounds for CEP72 Gene

(1) Drugs for CEP72 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vincristine Approved, Investigational Pharma Microtubule disrupter,antitumor agent 870
genes like me logo Genes that share compounds with CEP72: view

Transcripts for CEP72 Gene

Unigene Clusters for CEP72 Gene

Centrosomal protein 72kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP72 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - -
SP2: - - -
SP3:
SP4:
SP5:

Relevant External Links for CEP72 Gene

GeneLoc Exon Structure for
CEP72
ECgene alternative splicing isoforms for
CEP72

Expression for CEP72 Gene

mRNA expression in normal human tissues for CEP72 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEP72 Gene

This gene is overexpressed in Liver (40.4), Spleen (8.4), Testis (7.1), and Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP72 Gene



SOURCE GeneReport for Unigene cluster for CEP72 Gene Hs.591741

genes like me logo Genes that share expression patterns with CEP72: view

Protein tissue co-expression partners for CEP72 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP72 Gene

Orthologs for CEP72 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP72 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEP72 35
  • 75.64 (n)
  • 68.14 (a)
CEP72 36
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP72 35
  • 76.92 (n)
  • 70.23 (a)
CEP72 36
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep72 35
  • 73.58 (n)
  • 67.55 (a)
Cep72 16
Cep72 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CEP72 35
  • 98.31 (n)
  • 97.62 (a)
CEP72 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep72 35
  • 74.15 (n)
  • 67.08 (a)
oppossum
(Monodelphis domestica)
Mammalia CEP72 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP72 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP72 36
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cep72 36
  • 27 (a)
OneToOne
Species with no ortholog for CEP72:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP72 Gene

ENSEMBL:
Gene Tree for CEP72 (if available)
TreeFam:
Gene Tree for CEP72 (if available)

Paralogs for CEP72 Gene

Paralogs for CEP72 Gene

genes like me logo Genes that share paralogs with CEP72: view

Variants for CEP72 Gene

Sequence variations from dbSNP and Humsavar for CEP72 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs869955 - 635,393(-) ACTGC(A/G)GGCTC nc-transcript-variant, reference, missense
rs12522955 - 639,116(+) CTCTA(A/C)CCGGG nc-transcript-variant, reference, missense
rs868649 - 640,590(-) GTGTG(C/T)GTGGT nc-transcript-variant, reference, missense
rs868648 -- 640,767(-) AGGCC(A/G)CGTTC intron-variant, nc-transcript-variant
rs870571 -- 634,660(+) CTGGC(C/T)GTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP72 Gene

Variant ID Type Subtype PubMed ID
esv2752071 CNV Gain 17911159
nsv880710 CNV Loss 21882294
dgv5883n71 CNV Gain 21882294
dgv5884n71 CNV Gain 21882294
nsv881305 CNV Loss 21882294
nsv509042 CNV Insertion 20534489
nsv881103 CNV Gain 21882294
nsv830185 CNV Gain 17160897
dgv685n27 CNV Gain 19166990
dgv5892n71 CNV Gain 21882294
dgv5893n71 CNV Gain 21882294
nsv510933 CNV Complex 20534489
nsv461893 CNV Loss 19166990
nsv461894 CNV Gain 19166990
nsv525620 CNV Gain 19592680
dgv5n29 CNV Gain 16826518
nsv471627 CNV Gain+Loss 15918152
esv2666809 CNV Deletion 23128226
dgv1735e1 CNV Complex 17122850
dgv1736e1 CNV Complex 17122850
nsv428459 CNV Gain+Loss 18775914
esv2729333 CNV Deletion 23290073
esv24755 CNV Gain+Loss 19812545
nsv822928 CNV Loss 20364138
esv1229549 CNV Insertion 17803354
esv1293034 CNV Insertion 17803354
esv1064367 CNV Insertion 17803354
nsv327941 CNV Loss 16902084
nsv329867 CNV Insertion 16902084
nsv821539 CNV Deletion 20802225
esv2729334 CNV Deletion 23290073
esv1250929 CNV Insertion 17803354
nsv328511 CNV Loss 16902084
esv2729335 CNV Deletion 23290073
nsv10652 CNV Loss 18304495
esv2729336 CNV Deletion 23290073
nsv881247 CNV Gain 21882294
esv1512084 CNV Insertion 17803354
esv1280202 CNV Insertion 17803354
esv2656973 CNV Deletion 23128226
esv2729337 CNV Deletion 23290073
esv1630106 CNV Deletion 17803354
essv13335 CNV CNV 17122850
dgv1737e1 CNV Complex 17122850
esv1003099 CNV Deletion 20482838
esv25844 CNV Loss 19812545
esv2729338 CNV Deletion 23290073
nsv10653 CNV Loss 18304495
esv988499 CNV Loss 20482838
esv1926133 CNV Deletion 18987734
esv2729340 CNV Deletion 23290073
dgv954e201 CNV Deletion 23290073
esv2729342 CNV Deletion 23290073
esv2729343 CNV Deletion 23290073
nsv327962 CNV Loss 16902084
esv1785686 CNV Deletion 17803354
nsv328227 CNV Loss 16902084
esv2729345 CNV Deletion 23290073
esv1645370 CNV Insertion 17803354
nsv513208 CNV Loss 21212237
nsv329670 CNV Loss 16902084
esv2729346 CNV Deletion 23290073
esv1560788 CNV Deletion 17803354
esv1436922 CNV Deletion 17803354
esv1218667 CNV Deletion 17803354
nsv822929 CNV Loss 20364138
dgv5894n71 CNV Gain+Loss 21882294

Variation tolerance for CEP72 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CEP72 Gene

Disorders for CEP72 Gene

Relevant External Links for CEP72

Genetic Association Database (GAD)
CEP72
Human Genome Epidemiology (HuGE) Navigator
CEP72
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP72

No disorders were found for CEP72 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP72 Gene

Publications for CEP72 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia. (PMID: 25710658) Diouf B. … Evans W.E. (JAMA 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. (PMID: 26297806) Kodani A. … Reiter J.F. (Elife 2015) 3

Products for CEP72 Gene

Sources for CEP72 Gene

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