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Aliases for CEP70 Gene

Aliases for CEP70 Gene

  • Centrosomal Protein 70kDa 2 3
  • P10-Binding Protein 3 4
  • BITE 3 4
  • Cep70 4

External Ids for CEP70 Gene

Previous GeneCards Identifiers for CEP70 Gene

  • GC03M139696
  • GC03M138213
  • GC03M135587

Summaries for CEP70 Gene

GeneCards Summary for CEP70 Gene

CEP70 (Centrosomal Protein 70kDa) is a Protein Coding gene. Diseases associated with CEP70 include bruxism and ovarian carcinosarcoma. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for CEP70 Gene

  • Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle

Gene Wiki entry for CEP70 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP70 Gene

Genomics for CEP70 Gene

Regulatory Elements for CEP70 Gene

Genomic Location for CEP70 Gene

Chromosome:
3
Start:
138,494,339 bp from pter
End:
138,594,538 bp from pter
Size:
100,200 bases
Orientation:
Minus strand

Genomic View for CEP70 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP70 Gene

Proteins for CEP70 Gene

  • Protein details for CEP70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHQ1-CEP70_HUMAN
    Recommended name:
    Centrosomal protein of 70 kDa
    Protein Accession:
    Q8NHQ1
    Secondary Accessions:
    • B7Z5I8
    • B7Z7E8
    • D3DNE9
    • F5GZX8
    • Q96B31
    • Q9H2C3
    • Q9H2Z1
    • Q9H940

    Protein attributes for CEP70 Gene

    Size:
    597 amino acids
    Molecular mass:
    69752 Da
    Quaternary structure:
    • Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.

    Alternative splice isoforms for CEP70 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP70 Gene

Proteomics data for CEP70 Gene at MOPED

Post-translational modifications for CEP70 Gene

  • Ubiquitination at Lys 280, Lys 315, Lys 323, and Lys 370
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP70 Gene

Domains & Families for CEP70 Gene

Protein Domains for CEP70 Gene

Suggested Antigen Peptide Sequences for CEP70 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NHQ1

UniProtKB/Swiss-Prot:

CEP70_HUMAN :
  • The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization
  • Contains 1 TPR repeat.
Domain:
  • The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization
Similarity:
  • Contains 1 TPR repeat.
genes like me logo Genes that share domains with CEP70: view

No data available for Gene Families for CEP70 Gene

Function for CEP70 Gene

Molecular function for CEP70 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle

Gene Ontology (GO) - Molecular Function for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CEP70: view
genes like me logo Genes that share phenotypes with CEP70: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP70 Gene

Localization for CEP70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP70 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized at the center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP70 Gene COMPARTMENTS Subcellular localization image for CEP70 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with CEP70: view

Pathways & Interactions for CEP70 Gene

genes like me logo Genes that share pathways with CEP70: view

Gene Ontology (GO) - Biological Process for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with CEP70: view

No data available for SIGNOR curated interactions for CEP70 Gene

Drugs & Compounds for CEP70 Gene

No Compound Related Data Available

Transcripts for CEP70 Gene

Unigene Clusters for CEP70 Gene

Centrosomal protein 70kDa:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP70

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP70 Gene

No ASD Table

Relevant External Links for CEP70 Gene

GeneLoc Exon Structure for
CEP70
ECgene alternative splicing isoforms for
CEP70

Expression for CEP70 Gene

mRNA expression in normal human tissues for CEP70 Gene

Protein differential expression in normal tissues from HIPED for CEP70 Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CEP70 Gene



SOURCE GeneReport for Unigene cluster for CEP70 Gene Hs.531962

genes like me logo Genes that share expression patterns with CEP70: view

Protein tissue co-expression partners for CEP70 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP70 Gene

Orthologs for CEP70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP70 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEP70 35
  • 88.7 (n)
  • 84.58 (a)
CEP70 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP70 35
  • 91.13 (n)
  • 87.56 (a)
CEP70 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep70 35
  • 83.87 (n)
  • 79.6 (a)
Cep70 16
Cep70 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CEP70 35
  • 99.27 (n)
  • 98.32 (a)
CEP70 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep70 35
  • 82.87 (n)
  • 76.83 (a)
oppossum
(Monodelphis domestica)
Mammalia CEP70 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP70 35
  • 63.32 (n)
  • 55.11 (a)
CEP70 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP70 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15467 35
zebrafish
(Danio rerio)
Actinopterygii cep70 35
  • 50.18 (n)
  • 39.43 (a)
cep70 36
  • 35 (a)
OneToOne
Species with no ortholog for CEP70:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP70 Gene

ENSEMBL:
Gene Tree for CEP70 (if available)
TreeFam:
Gene Tree for CEP70 (if available)

Paralogs for CEP70 Gene

No data available for Paralogs for CEP70 Gene

Variants for CEP70 Gene

Sequence variations from dbSNP and Humsavar for CEP70 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs9049 -- 138,494,450(-) GATGA(A/G)TAGAT utr-variant-3-prime
rs391564 -- 138,522,163(-) aggca(A/G)aggac intron-variant
rs497334 -- 138,567,338(+) ATTAT(A/T)CTCCA intron-variant
rs515510 -- 138,545,485(-) acatg(C/T)tctac intron-variant
rs523975 -- 138,595,621(-) CTTAT(C/T)GGCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CEP70 Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914
nsv877537 CNV Gain 21882294
nsv522517 CNV Loss 19592680
nsv877538 CNV Loss 21882294
nsv877539 CNV Loss 21882294

Variation tolerance for CEP70 Gene

Residual Variation Intolerance Score: 61.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP70 Gene

HapMap Linkage Disequilibrium report
CEP70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP70 Gene

Disorders for CEP70 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CEP70 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bruxism
  • bruxism - teeth grinding
ovarian carcinosarcoma
  • ovarian malignant mixed mullerian tumor
- elite association
Search CEP70 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CEP70

Genetic Association Database (GAD)
CEP70
Human Genome Epidemiology (HuGE) Navigator
CEP70
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP70
genes like me logo Genes that share disorders with CEP70: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEP70 Gene

Publications for CEP70 Gene

  1. Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos. (PMID: 19254375) Wilkinson C.J. … Harris W.A. (BMC Cell Biol. 2009) 23 67
  2. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen J.S. … Mann M. (Nature 2003) 2 67
  3. Cep70 regulates microtubule stability by interacting with HDAC6. (PMID: 26112604) Shi X. … Li D. (FEBS Lett. 2015) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 67

Products for CEP70 Gene

Sources for CEP70 Gene

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