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Aliases for CEP70 Gene

Aliases for CEP70 Gene

  • Centrosomal Protein 70 2 3 5
  • Centrosomal Protein 70kDa 2 3
  • P10-Binding Protein 3 4
  • BITE 3 4
  • Testicular Tissue Protein Li 36 3
  • Centrosomal Protein Of 70 KDa 3
  • Cep70 4

External Ids for CEP70 Gene

Previous GeneCards Identifiers for CEP70 Gene

  • GC03M139696
  • GC03M138213
  • GC03M135587

Summaries for CEP70 Gene

GeneCards Summary for CEP70 Gene

CEP70 (Centrosomal Protein 70) is a Protein Coding gene. Diseases associated with CEP70 include Mandibular Cancer and Jaw Cancer. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for CEP70 Gene

  • Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.

Gene Wiki entry for CEP70 Gene

Additional gene information for CEP70 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP70 Gene

Genomics for CEP70 Gene

Regulatory Elements for CEP70 Gene

Enhancers for CEP70 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H138914 1.7 FANTOM5 Ensembl ENCODE 12.2 -321.3 -321318 2 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 CEP70 PIK3CB FAIM LINC01391 FOXL2NB FOXL2 ATP5G1P3
GH03H138942 1.5 Ensembl ENCODE dbSUPER 10.3 -350.8 -350752 6 HDGF ATF1 ZNF766 ELK1 FOS ATF7 REST SMARCB1 ZNF592 SNIP1 DBR1 DZIP1L ENSG00000272656 CEP70 ACTG1P1 COPB2 MRAS LINC01391 FOXL2
GH03H138935 1.5 Ensembl ENCODE dbSUPER 10.2 -341.7 -341694 1 HDGF ATF1 ZFP64 SIN3A ZNF2 ZNF143 ATF7 RUNX3 DEK REST CEP70 LINC01391 ATP5G1P3
GH03H138685 1.3 Ensembl ENCODE 11.3 -92.4 -92376 2 PKNOX1 FOXA2 ATF1 ARID4B FEZF1 ZNF2 TCF12 SLC30A9 ATF7 RUNX3 FAIM CEP70 PIK3CB GC03P138644 GAPDHP39
GH03H138888 1.4 Ensembl ENCODE dbSUPER 10.4 -295.8 -295763 3 PKNOX1 FOXA2 CHAMP1 GTF3C2 RUNX3 IKZF2 NCOA1 ZNF592 ZNF589 IKZF1 PIK3CB DBR1 COPB2 ACTG1P1 CEP70 DZIP1L FAIM A4GNT ATP5G1P3 LINC01391
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEP70 on UCSC Golden Path with GeneCards custom track

Promoters for CEP70 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000159036 438 1801 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143

Genomic Location for CEP70 Gene

Chromosome:
3
Start:
138,494,339 bp from pter
End:
138,594,538 bp from pter
Size:
100,200 bases
Orientation:
Minus strand

Genomic View for CEP70 Gene

Genes around CEP70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP70 Gene

Proteins for CEP70 Gene

  • Protein details for CEP70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHQ1-CEP70_HUMAN
    Recommended name:
    Centrosomal protein of 70 kDa
    Protein Accession:
    Q8NHQ1
    Secondary Accessions:
    • B7Z5I8
    • B7Z7E8
    • D3DNE9
    • F5GZX8
    • Q96B31
    • Q9H2C3
    • Q9H2Z1
    • Q9H940

    Protein attributes for CEP70 Gene

    Size:
    597 amino acids
    Molecular mass:
    69752 Da
    Quaternary structure:
    • Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.

    Alternative splice isoforms for CEP70 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP70 Gene

Post-translational modifications for CEP70 Gene

  • Ubiquitination at Lys280, Lys315, posLast=323323, and posLast=370370
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP70 Gene

Domains & Families for CEP70 Gene

Gene Families for CEP70 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CEP70 Gene

Suggested Antigen Peptide Sequences for CEP70 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NHQ1

UniProtKB/Swiss-Prot:

CEP70_HUMAN :
  • The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.
Domain:
  • The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.
genes like me logo Genes that share domains with CEP70: view

Function for CEP70 Gene

Molecular function for CEP70 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.

Phenotypes From GWAS Catalog for CEP70 Gene

Gene Ontology (GO) - Molecular Function for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with CEP70: view
genes like me logo Genes that share phenotypes with CEP70: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CEP70
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP70 Gene

Localization for CEP70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP70 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized at the center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP70 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 4
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CEP70: view

Pathways & Interactions for CEP70 Gene

genes like me logo Genes that share pathways with CEP70: view

Gene Ontology (GO) - Biological Process for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0010389 regulation of G2/M transition of mitotic cell cycle TAS --
GO:0097711 ciliary basal body docking TAS --
genes like me logo Genes that share ontologies with CEP70: view

No data available for SIGNOR curated interactions for CEP70 Gene

Drugs & Compounds for CEP70 Gene

No Compound Related Data Available

Transcripts for CEP70 Gene

Unigene Clusters for CEP70 Gene

Centrosomal protein 70kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CEP70
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CEP70 Gene

No ASD Table

Relevant External Links for CEP70 Gene

GeneLoc Exon Structure for
CEP70
ECgene alternative splicing isoforms for
CEP70

Expression for CEP70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEP70 Gene

Protein differential expression in normal tissues from HIPED for CEP70 Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CEP70 Gene



Protein tissue co-expression partners for CEP70 Gene

NURSA nuclear receptor signaling pathways regulating expression of CEP70 Gene:

CEP70

SOURCE GeneReport for Unigene cluster for CEP70 Gene:

Hs.531962

Evidence on tissue expression from TISSUES for CEP70 Gene

  • Skin(4.5)
  • Blood(4.3)
  • Nervous system(3.2)
  • Muscle(2.7)
  • Bone(2.3)
genes like me logo Genes that share expression patterns with CEP70: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP70 Gene

Orthologs for CEP70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP70 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP70 33 34
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia CEP70 33 34
  • 91.13 (n)
cow
(Bos Taurus)
Mammalia CEP70 33 34
  • 88.7 (n)
mouse
(Mus musculus)
Mammalia Cep70 33 16 34
  • 83.87 (n)
rat
(Rattus norvegicus)
Mammalia Cep70 33
  • 82.87 (n)
oppossum
(Monodelphis domestica)
Mammalia CEP70 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP70 33 34
  • 63.32 (n)
lizard
(Anolis carolinensis)
Reptilia CEP70 34
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15467 33
zebrafish
(Danio rerio)
Actinopterygii cep70 33 34
  • 50.18 (n)
Species where no ortholog for CEP70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP70 Gene

ENSEMBL:
Gene Tree for CEP70 (if available)
TreeFam:
Gene Tree for CEP70 (if available)

Paralogs for CEP70 Gene

No data available for Paralogs for CEP70 Gene

Variants for CEP70 Gene

Sequence variations from dbSNP and Humsavar for CEP70 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000005889 -- 138,513,430(+) TCCAC(G/T)CTGAC intron-variant
rs1000007382 -- 138,537,680(+) TCAGG(A/G)AAGAA intron-variant
rs1000079825 -- 138,557,666(+) AAAGG(G/T)TGAAA intron-variant
rs1000093204 -- 138,503,392(+) GTATA(C/T)ACCAC intron-variant, utr-variant-3-prime
rs1000102623 -- 138,509,418(+) TCCAG(A/G/T)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP70 Gene

Variant ID Type Subtype PubMed ID
dgv4908n100 CNV gain 25217958
esv3597916 CNV gain 21293372
esv3597917 CNV loss 21293372
esv3597918 CNV loss 21293372
nsv428422 CNV gain+loss 18775914
nsv522517 CNV loss 19592680
nsv999041 CNV gain 25217958

Variation tolerance for CEP70 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP70 Gene

Disorders for CEP70 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CEP70 Gene - From: DISEASES

Disorder Aliases PubMed IDs
mandibular cancer
  • malignant neoplasm of inferior maxilla
jaw cancer
  • jaw neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search CEP70 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CEP70

Genetic Association Database (GAD)
CEP70
Human Genome Epidemiology (HuGE) Navigator
CEP70
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP70
genes like me logo Genes that share disorders with CEP70: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEP70 Gene

Publications for CEP70 Gene

  1. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen JS … Mann M (Nature 2003) 2 3 4 60
  2. CEP70 protein interacts with γ-tubulin to localize at the centrosome and is critical for mitotic spindle assembly. (PMID: 21795687) Shi X … Zhou J (The Journal of biological chemistry 2011) 3 4 60
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for CEP70 Gene

Sources for CEP70 Gene

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