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CEP70 Gene

protein-coding   GIFtS: 59
GCID: GC03M138213

Centrosomal Protein 70kDa

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centrosomal Protein 70kDa1 2
BITE2 3
P10-Binding Protein2 3
Centrosomal Protein Of 70 KDa2
Cep703

External Ids:    HGNC: 299721   Entrez Gene: 803212   Ensembl: ENSG000001141077   OMIM: 6143105   UniProtKB: Q8NHQ13   

Export aliases for CEP70 gene to outside databases

Previous GC identifers: GC03M139696 GC03M135587


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CEP70 Gene:
CEP70 (centrosomal protein 70kDa) is a protein-coding gene.

UniProtKB/Swiss-Prot: CEP70_HUMAN, Q8NHQ1
Function: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells.
During mitosis, required for the organization and orientation of the mitotic spindle

Gene Wiki entry for CEP70 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CEP70 gene promoter:
         Egr-3   AML1a   SREBP-1c   SREBP-1b   Egr-2   MZF-1   CREB   SREBP-1a   deltaCREB   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEP70 promoter sequence
   Search Chromatin IP Primers for CEP70

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEP70


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.3   Ensembl cytogenetic band:  3q22.3   HGNC cytogenetic band: 3q22.3

CEP70 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP70 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M138213:  view genomic region     (about GC identifiers)

Start:
138,213,186 bp from pter      End:
138,313,380 bp from pter
Size:
100,195 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CEP70_HUMAN, Q8NHQ1 (See protein sequence)
Recommended Name: Centrosomal protein of 70 kDa  
Size: 597 amino acids; 69752 Da
Subunit: Directly interacts with tubulin-gamma; this interaction determines centrosomal localization
Secondary accessions: B7Z5I8 B7Z7E8 D3DNE9 F5GZX8 Q96B31 Q9H2C3 Q9H2Z1 Q9H940
Alternative splicing: 5 isoforms:  Q8NHQ1-1   Q8NHQ1-2   Q8NHQ1-3   Q8NHQ1-4   Q8NHQ1-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CEP70: NX_Q8NHQ1

Explore proteomics data for CEP70 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys280, Lys315, Lys323, Lys370
  • Modification sites at PhosphoSitePlus

  • See CEP70 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001275893.1  NP_001275894.1  NP_001275895.1  NP_001275896.1  NP_077817.2  

    ENSEMBL proteins: 
     ENSP00000264982   ENSP00000417821   ENSP00000419231   ENSP00000419833   ENSP00000418552  
     ENSP00000417465   ENSP00000418131   ENSP00000417819   ENSP00000419743   ENSP00000419817  
     ENSP00000418878   ENSP00000444128  
    Reactome Protein details: Q8NHQ1

    CEP70 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CEP70

     
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    antibodies-online proteins for CEP70 (5 products) 

     
    antibodies-online peptides for CEP70

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry Q8NHQ1

    ProtoNet protein and cluster: Q8NHQ1

    1 Blocks protein domain: IPB011072 Protein kinase PKN/PRK1

    UniProtKB/Swiss-Prot: CEP70_HUMAN, Q8NHQ1
    Domain: The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization
    Similarity: Contains 1 TPR repeat


    Find genes that share domains with CEP70           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEP70_HUMAN, Q8NHQ1
    Function: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells.
    During mitosis, required for the organization and orientation of the mitotic spindle

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with CEP70           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CEP70:
     Synthetic lethal with c-Myc af 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CEP70

    miRNA
    Products:
        
    miRTarBase miRNAs that target CEP70:
    hsa-mir-375 (MIRT020024)

    Block miRNA regulation of human, mouse, rat CEP70 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CEP70:
    hsa-miR-3163 hsa-miR-502-5p hsa-miR-488 hsa-miR-340 hsa-miR-500a hsa-miR-466 hsa-miR-590-3p hsa-miR-3941
    SwitchGear 3'UTR luciferase reporter plasmidCEP70 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CEP70
    Predesigned siRNA for gene silencing in human, mouse, rat CEP70

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    GenScript: all cDNA clones in your preferred vector: CEP70 (NM_024491)
    Sino Biological Human cDNA Clone for CEP70
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEP70
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP70

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP70


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CEP70_HUMAN, Q8NHQ1: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized at the
    center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus4
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CEP70           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CEP70 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90


    Find genes that share SuperPaths with CEP70           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4 Reactome Pathways for CEP70
        Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition
    Loss of Nlp from mitotic centrosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CEP70
    Interactions:

        Search GeneGlobe Interaction Network for CEP70

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CEP70 (Q8NHQ11, 2, 3 ENSP000002649824) via UniProtKB, MINT, STRING, and/or I2D (see all 97)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COILP384321, 2, 3, ENSP000002403164EBI-739624,EBI-945751 MINT-2876726 MINT-2876707 I2D: score=3 STRING: ENSP00000240316
    CCDC85BQ158342, 3, ENSP000003116954MINT-67861 I2D: score=5 STRING: ENSP00000311695
    KAT7O952512, 3, ENSP000002590214MINT-66201 I2D: score=5 STRING: ENSP00000259021
    TRIM29Q141342, 3, ENSP000003431294MINT-67676 I2D: score=5 STRING: ENSP00000343129
    KANSL1Q7Z3B32, 3, ENSP000002624194MINT-67988 I2D: score=4 STRING: ENSP00000262419
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--

    Find genes that share ontologies with CEP70           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CEP70



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CEP70 gene (5 alternative transcripts): 
    NM_001288964.1  NM_001288965.1  NM_001288966.1  NM_001288967.1  NM_024491.3  

    Unigene Cluster for CEP70:

    Centrosomal protein 70kDa
    Hs.531962  [show with all ESTs]
    Unigene Representative Sequence: NM_024491
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264982(uc003esl.3 uc011bmk.2 uc011bml.2 uc011bmm.2)
    ENST00000489254 ENST00000484888 ENST00000474781 ENST00000459695 ENST00000481834(uc003esm.3)
    ENST00000468900 ENST00000462419 ENST00000478673 ENST00000464035(uc003esn.3)
    ENST00000470159 ENST00000485115 ENST00000460967 ENST00000542237
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate CEP70:
    hsa-miR-3163 hsa-miR-502-5p hsa-miR-488 hsa-miR-340 hsa-miR-500a hsa-miR-466 hsa-miR-590-3p hsa-miR-3941
    SwitchGear 3'UTR luciferase reporter plasmidCEP70 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CEP70
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CEP70 (NM_024491)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP70
    Primer
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    OriGene qPCR primer pairs and template standards for CEP70
    OriGene qSTAR qPCR primer pairs in human, mouse for CEP70
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      QuantiTect SYBR Green Assays in human, mouse, rat CEP70
      QuantiFast Probe-based Assays in human, mouse, rat CEP70

    Additional mRNA sequence: 

    AF202146.1 AF289495.1 AK023098.1 AK225440.1 AK294587.1 AK295866.1 AK299003.1 AK301913.1 
    AK314314.1 BC016050.2 BC030598.2 

    16 DOTS entries:

    DT.409734  DT.91753650  DT.100814106  DT.100814105  DT.97843055  DT.100660386  DT.104600  DT.40219058 
    DT.101966365  DT.97843052  DT.120908511  DT.430584  DT.75178140  DT.95376290  DT.95376288  DT.100698951 

    Selected AceView cDNA sequences (see all 133):

    BM819202 AI278937 NM_024491 AW273604 BM833067 BP356241 AI683285 BM832862 
    BF222218 AI018144 AI699036 AI082807 CB138454 BF000663 AI399743 BF435951 
    AA687585 BP356268 AW167770 AI000520 AA985505 BC016050 BG761327 BM802320 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CEP70 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGTTGCCC
    CEP70 Expression
    About this image


    CEP70 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    CEP70 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEP70 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531962
        Custom PCR Arrays for CEP70
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP70

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CEP70 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cep701 , 5 centrosomal protein 701, 5 83.87(n)1
    79.6(a)1
      9 (51.45 cM)5
    681211  NM_023873.31  NP_076362.21 
     992434685 
    chicken
    (Gallus gallus)
    Aves CEP701 centrosomal protein 70kDa 63.32(n)
    55.11(a)
      429044  XM_426601.3  XP_426601.2 
    lizard
    (Anolis carolinensis)
    Reptilia CEP706
    centrosomal protein 70kDa
    50(a)
    1 ↔ 1
    1(77393380-77407172)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.154672 Xenopus laevis transcribed sequence with weak similarity more 70.6(n)    BJ087315.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AL920338.12   -- 69.24(n)    AL920338.1 


    ENSEMBL Gene Tree for CEP70 (if available)
    TreeFam Gene Tree for CEP70 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CEP70 (see all 2218)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1824198721,2
    --138212773(+) ATCTAC/GAAGGA 1 -- int10--------
    rs791732401,2
    C,F--138212776(+) TAGAAG/AGAGCC 1 -- int11Minor allele frequency- A:0.01NA 120
    rs1445943061,2
    --138212797(+) CGTCTA/GATCCC 1 -- int10--------
    rs1862139551,2
    C--138212883(+) AATGTA/GTTATA 1 -- int10--------
    rs803285051,2
    C,F--138212953(+) AAAAGT/CGGGGA 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1384113171,2
    C--138213002(+) CAGAAC/TGCTGA 1 -- int10--------
    rs783412921,2
    C,F--138213003(+) AGAACG/ACTGAC 1 -- int11Minor allele frequency- A:0.02NA 120
    rs1914364651,2
    --138213029(+) ACTGCA/GTATTG 1 -- int10--------
    rs1163566451,2
    C,F--138213065(+) CAAGTA/GAAGTA 1 -- int11Minor allele frequency- G:0.02WA 118
    rs1162465251,2
    C,F--138213125(+) AGCCTA/CGGAAG 1 -- int11Minor allele frequency- C:0.04NA 120

    HapMap Linkage Disequilibrium report for CEP70 (138213186 - 138313380 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CEP70:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv522517CNV Loss19592680
    nsv877539CNV Loss21882294
    nsv877538CNV Loss21882294
    nsv877537CNV Gain21882294
    nsv428422CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CEP70
    DNA2.0 Custom Variant and Variant Library Synthesis for CEP70

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614310    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for CEP70:
    Situs inversus     Bardet-Biedl syndrome

    Find genes that share disorders with CEP70           About GenesLikeMe

    Genetic Association Database (GAD): CEP70
    Human Genome Epidemiology (HuGE) Navigator: CEP70 (1 document)

    Export disorders for CEP70 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CEP70 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with CEP70)
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    1. Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843)1, 2, 3 Andersen J.S....Mann M. (Nature 2003)
    2. CEP70 protein interacts with gamma-tubulin to localize at the centrosome and is critical for mitotic spindle assembly. (PubMed id 21795687)1, 2 Shi X.... Zhou J. (J. Biol. Chem. 2011)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    7. Cep70 promotes microtubule assembly in vitro by increasing microtubule elongation. (PubMed id 22427462)1 Shi X....Li D. (Acta Biochim. Biophys. Sin. (Shanghai) 2012)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    10. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (Hum. Mol. Genet. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80321 HGNC: 29972 AceView: Cep70 Ensembl:ENSG00000114107 euGenes: HUgn80321
    ECgene: CEP70 H-InvDB: CEP70

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CEP70 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CEP70 gene:
    Search GeneIP for patents involving CEP70

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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