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Aliases for CEP70 Gene

Aliases for CEP70 Gene

  • Centrosomal Protein 70kDa 2 3
  • P10-Binding Protein 3 4
  • BITE 3 4
  • Centrosomal Protein Of 70 KDa 3
  • Cep70 4

External Ids for CEP70 Gene

Previous GeneCards Identifiers for CEP70 Gene

  • GC03M139696
  • GC03M138213
  • GC03M135587

Summaries for CEP70 Gene

GeneCards Summary for CEP70 Gene

CEP70 (Centrosomal Protein 70kDa) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CEP70 Gene

  • Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle

Gene Wiki entry for CEP70 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP70 Gene

Genomics for CEP70 Gene

Regulatory Elements for CEP70 Gene

Genomic Location for CEP70 Gene

Start:
138,494,339 bp from pter
End:
138,594,538 bp from pter
Size:
100,200 bases
Orientation:
Minus strand

Genomic View for CEP70 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP70 Gene

Proteins for CEP70 Gene

  • Protein details for CEP70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHQ1-CEP70_HUMAN
    Recommended name:
    Centrosomal protein of 70 kDa
    Protein Accession:
    Q8NHQ1
    Secondary Accessions:
    • B7Z5I8
    • B7Z7E8
    • D3DNE9
    • F5GZX8
    • Q96B31
    • Q9H2C3
    • Q9H2Z1
    • Q9H940

    Protein attributes for CEP70 Gene

    Size:
    597 amino acids
    Molecular mass:
    69752 Da
    Quaternary structure:
    • Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.

    Alternative splice isoforms for CEP70 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP70 Gene

Proteomics data for CEP70 Gene at MOPED

Post-translational modifications for CEP70 Gene

  • Ubiquitination at Lys280, Lys315, Lys323, and Lys370
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP70 Gene

Domains for CEP70 Gene

Protein Domains for CEP70 Gene

Suggested Antigen Peptide Sequences for CEP70 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NHQ1

UniProtKB/Swiss-Prot:

CEP70_HUMAN :
  • Q8NHQ1
Domain:
  • The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization
Similarity:
  • Contains 1 TPR repeat.
genes like me logo Genes that share domains with CEP70: view

No data available for Gene Families for CEP70 Gene

Function for CEP70 Gene

Molecular function for CEP70 Gene

UniProtKB/Swiss-Prot Function: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle

Gene Ontology (GO) - Molecular Function for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CEP70: view

Phenotypes for CEP70 Gene

GenomeRNAi human phenotypes for CEP70:
genes like me logo Genes that share phenotypes with CEP70: view

Animal Model Products

CRISPR Products

miRNA for CEP70 Gene

miRTarBase miRNAs that target CEP70

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEP70 Gene

Localization for CEP70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP70 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized at the center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP70 Gene COMPARTMENTS Subcellular localization image for CEP70 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CEP70: view

Pathways for CEP70 Gene

genes like me logo Genes that share pathways with CEP70: view

Gene Ontology (GO) - Biological Process for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with CEP70: view

Transcripts for CEP70 Gene

Unigene Clusters for CEP70 Gene

Centrosomal protein 70kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP70

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP70 Gene

No ASD Table

Relevant External Links for CEP70 Gene

GeneLoc Exon Structure for
CEP70
ECgene alternative splicing isoforms for
CEP70

Expression for CEP70 Gene

mRNA expression in normal human tissues for CEP70 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CEP70 Gene

SOURCE GeneReport for Unigene cluster for CEP70 Gene Hs.531962

genes like me logo Genes that share expressions with CEP70: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP70 Gene

Orthologs for CEP70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP70 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP70 35
  • 99.27 (n)
  • 98.32 (a)
CEP70 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEP70 35
  • 88.7 (n)
  • 84.58 (a)
CEP70 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP70 35
  • 91.13 (n)
  • 87.56 (a)
CEP70 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep70 35
  • 83.87 (n)
  • 79.6 (a)
Cep70 16
Cep70 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEP70 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep70 35
  • 82.87 (n)
  • 76.83 (a)
chicken
(Gallus gallus)
Aves CEP70 35
  • 63.32 (n)
  • 55.11 (a)
CEP70 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP70 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15467 35
zebrafish
(Danio rerio)
Actinopterygii cep70 35
  • 50.18 (n)
  • 39.43 (a)
cep70 36
  • 35 (a)
OneToOne
Species with no ortholog for CEP70:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP70 Gene

ENSEMBL:
Gene Tree for CEP70 (if available)
TreeFam:
Gene Tree for CEP70 (if available)

Paralogs for CEP70 Gene

No data available for Paralogs for CEP70 Gene

Variants for CEP70 Gene

Sequence variations from dbSNP and Humsavar for CEP70 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs9049 -- 138,494,450(-) GATGA(A/G)TAGAT utr-variant-3-prime
rs391564 -- 138,522,163(-) aggca(A/G)aggac intron-variant
rs497334 -- 138,567,338(+) ATTAT(A/T)CTCCA intron-variant
rs515510 -- 138,545,485(-) acatg(C/T)tctac intron-variant
rs523975 -- 138,595,621(-) CTTAT(C/T)GGCTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CEP70 Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914
nsv877537 CNV Gain 21882294
nsv522517 CNV Loss 19592680
nsv877538 CNV Loss 21882294
nsv877539 CNV Loss 21882294

Relevant External Links for CEP70 Gene

HapMap Linkage Disequilibrium report
CEP70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP70 Gene

Disorders for CEP70 Gene

(2) University of Copenhagen DISEASES for CEP70 Gene

Relevant External Links for CEP70

Genetic Association Database (GAD)
CEP70
Human Genome Epidemiology (HuGE) Navigator
CEP70
genes like me logo Genes that share disorders with CEP70: view

No data available for UniProtKB/Swiss-Prot for CEP70 Gene

Publications for CEP70 Gene

  1. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen J.S. … Mann M. (Nature 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. CEP70 protein interacts with gamma-tubulin to localize at the centrosome and is critical for mitotic spindle assembly. (PMID: 21795687) Shi X. … Zhou J. (J. Biol. Chem. 2011) 3 4
  5. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 48

Products for CEP70 Gene

Sources for CEP70 Gene

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