Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CEP70 Gene

Aliases for CEP70 Gene

  • Centrosomal Protein 70 2 3 5
  • Centrosomal Protein 70kDa 2 3
  • P10-Binding Protein 3 4
  • BITE 3 4
  • Testicular Tissue Protein Li 36 3
  • Centrosomal Protein Of 70 KDa 3
  • Cep70 4

External Ids for CEP70 Gene

Previous GeneCards Identifiers for CEP70 Gene

  • GC03M139696
  • GC03M138213
  • GC03M135587

Summaries for CEP70 Gene

GeneCards Summary for CEP70 Gene

CEP70 (Centrosomal Protein 70) is a Protein Coding gene. Diseases associated with CEP70 include Bruxism and Mandibular Cancer. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CEP70 Gene

  • Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.

Gene Wiki entry for CEP70 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP70 Gene

Genomics for CEP70 Gene

Regulatory Elements for CEP70 Gene

Enhancers for CEP70 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CEP70 on UCSC Golden Path with GeneCards custom track

Promoters for CEP70 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEP70 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEP70 Gene

Chromosome:
3
Start:
138,494,339 bp from pter
End:
138,594,538 bp from pter
Size:
100,200 bases
Orientation:
Minus strand

Genomic View for CEP70 Gene

Genes around CEP70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP70 Gene

Proteins for CEP70 Gene

  • Protein details for CEP70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHQ1-CEP70_HUMAN
    Recommended name:
    Centrosomal protein of 70 kDa
    Protein Accession:
    Q8NHQ1
    Secondary Accessions:
    • B7Z5I8
    • B7Z7E8
    • D3DNE9
    • F5GZX8
    • Q96B31
    • Q9H2C3
    • Q9H2Z1
    • Q9H940

    Protein attributes for CEP70 Gene

    Size:
    597 amino acids
    Molecular mass:
    69752 Da
    Quaternary structure:
    • Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.

    Alternative splice isoforms for CEP70 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP70 Gene

Post-translational modifications for CEP70 Gene

  • Ubiquitination at Lys 280, Lys 315, Lys 323, and Lys 370
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP70 Gene

Domains & Families for CEP70 Gene

Protein Domains for CEP70 Gene

Suggested Antigen Peptide Sequences for CEP70 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NHQ1

UniProtKB/Swiss-Prot:

CEP70_HUMAN :
  • The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.
  • Contains 1 TPR repeat.
Domain:
  • The coiled-coil domains may be important for tubulin-gamma-binding and hence for centrosomal localization.
Similarity:
  • Contains 1 TPR repeat.
genes like me logo Genes that share domains with CEP70: view

No data available for Gene Families for CEP70 Gene

Function for CEP70 Gene

Molecular function for CEP70 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.

Gene Ontology (GO) - Molecular Function for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with CEP70: view
genes like me logo Genes that share phenotypes with CEP70: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP70 Gene

Localization for CEP70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP70 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized at the center of the radial microtubule array in interphase and at the spindle poles during various stages of mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP70 Gene COMPARTMENTS Subcellular localization image for CEP70 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with CEP70: view

Pathways & Interactions for CEP70 Gene

genes like me logo Genes that share pathways with CEP70: view

Gene Ontology (GO) - Biological Process for CEP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with CEP70: view

No data available for SIGNOR curated interactions for CEP70 Gene

Drugs & Compounds for CEP70 Gene

No Compound Related Data Available

Transcripts for CEP70 Gene

Unigene Clusters for CEP70 Gene

Centrosomal protein 70kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP70 Gene

No ASD Table

Relevant External Links for CEP70 Gene

GeneLoc Exon Structure for
CEP70
ECgene alternative splicing isoforms for
CEP70

Expression for CEP70 Gene

mRNA expression in normal human tissues for CEP70 Gene

Protein differential expression in normal tissues from HIPED for CEP70 Gene

This gene is overexpressed in Fetal heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CEP70 Gene



Protein tissue co-expression partners for CEP70 Gene

NURSA nuclear receptor signaling pathways regulating expression of CEP70 Gene:

CEP70

SOURCE GeneReport for Unigene cluster for CEP70 Gene:

Hs.531962
genes like me logo Genes that share expression patterns with CEP70: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP70 Gene

Orthologs for CEP70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP70 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEP70 34
  • 88.7 (n)
  • 84.58 (a)
CEP70 35
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP70 34
  • 91.13 (n)
  • 87.56 (a)
CEP70 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep70 34
  • 83.87 (n)
  • 79.6 (a)
Cep70 16
Cep70 35
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CEP70 34
  • 99.27 (n)
  • 98.32 (a)
CEP70 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep70 34
  • 82.87 (n)
  • 76.83 (a)
oppossum
(Monodelphis domestica)
Mammalia CEP70 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP70 34
  • 63.32 (n)
  • 55.11 (a)
CEP70 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP70 35
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15467 34
zebrafish
(Danio rerio)
Actinopterygii cep70 34
  • 50.18 (n)
  • 39.43 (a)
cep70 35
  • 35 (a)
OneToOne
Species where no ortholog for CEP70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP70 Gene

ENSEMBL:
Gene Tree for CEP70 (if available)
TreeFam:
Gene Tree for CEP70 (if available)

Paralogs for CEP70 Gene

No data available for Paralogs for CEP70 Gene

Variants for CEP70 Gene

Sequence variations from dbSNP and Humsavar for CEP70 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1673607 - 138,570,379(-) ACTAA(A/G)TAGGG intron-variant, reference, missense, utr-variant-5-prime
rs35340237 - 138,500,152(+) GCTCA(C/T)TCACA reference, missense
rs936316 -- 138,572,216(-) AGAGT(A/C)AGTTA intron-variant, upstream-variant-2KB
rs391564 -- 138,522,163(-) aggca(A/G)aggac intron-variant
rs9049 -- 138,494,450(-) GATGA(A/G)TAGAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CEP70 Gene

Variant ID Type Subtype PubMed ID
dgv4908n100 CNV gain 25217958
esv3597916 CNV gain 21293372
esv3597917 CNV loss 21293372
esv3597918 CNV loss 21293372
nsv428422 CNV gain+loss 18775914
nsv522517 CNV loss 19592680
nsv999041 CNV gain 25217958

Variation tolerance for CEP70 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP70 Gene

Disorders for CEP70 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CEP70 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bruxism
  • bruxism - teeth grinding
mandibular cancer
  • malignant neoplasm of inferior maxilla
jaw cancer
  • jaw neoplasm
ovarian carcinosarcoma
  • ovarian malignant mesodermal mixed tumor
- elite association - COSMIC cancer census association via MalaCards
Search CEP70 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CEP70

Genetic Association Database (GAD)
CEP70
Human Genome Epidemiology (HuGE) Navigator
CEP70
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP70
genes like me logo Genes that share disorders with CEP70: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEP70 Gene

Publications for CEP70 Gene

  1. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen J.S. … Mann M. (Nature 2003) 2 3 4 65
  2. CEP70 protein interacts with gamma-tubulin to localize at the centrosome and is critical for mitotic spindle assembly. (PMID: 21795687) Shi X. … Zhou J. (J. Biol. Chem. 2011) 3 4 65
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for CEP70 Gene

Sources for CEP70 Gene

Content