Aliases for CEP63 Gene
External Ids for CEP63 Gene
This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for CEP63 Gene
CEP63 (Centrosomal Protein 63kDa) is a Protein Coding gene. Diseases associated with CEP63 include seckel syndrome 6 and seckel syndrome. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. An important paralog of this gene is CCDC67.
UniProtKB/Swiss-Prot for CEP63 Gene
Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication, through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression.