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CEP63 Gene

protein-coding   GIFtS: 60
GCID: GC03P134204

Centrosomal Protein 63kDa

  See CEP63-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centrosomal Protein 63kDa1 2
SCKL62 5
Centrosomal Protein Of 63 KDa2
Centrosome Protein CEP632
Cep633

External Ids:    HGNC: 258151   Entrez Gene: 802542   Ensembl: ENSG000001829237   OMIM: 6147245   UniProtKB: Q96MT83   

Export aliases for CEP63 gene to outside databases

Previous GC identifers: GC03P135688 GC03P131583


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CEP63 Gene:
This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a
non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several
alternatively spliced transcript variants have been found, but their biological validity has not been determined.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CEP63 Gene:
CEP63 (centrosomal protein 63kDa) is a protein-coding gene. Diseases associated with CEP63 include seckel syndrome type 6, and primary autosomal recessive microcephaly type 1. An important paralog of this gene is CCDC67.

UniProtKB/Swiss-Prot: CEP63_HUMAN, Q96MT8
Function: Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole
duplication, through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA
damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this
leads to the inactivation of spindle assembly and delay in mitotic progression

Gene Wiki entry for CEP63 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CEP63 gene promoter:
         NF-1   SREBP-1a   SREBP-1c   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEP63 promoter sequence
   Search Chromatin IP Primers for CEP63

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEP63


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.2   Ensembl cytogenetic band:  3q22.2   HGNC cytogenetic band: 3q22.1

CEP63 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP63 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P134204:  view genomic region     (about GC identifiers)

Start:
134,204,575 bp from pter      End:
134,293,859 bp from pter
Size:
89,285 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CEP63_HUMAN, Q96MT8 (See protein sequence)
Recommended Name: Centrosomal protein of 63 kDa  
Size: 703 amino acids; 81344 Da
Subunit: Interacts with CEP152 and CDK1; these interactions recruit both ligands to centrosomes. May also interact
with CDK2
Miscellaneous: CEP63 and CCDC67/DEUP1 paralogs are both involved in centriole amplification: while CEP63 mediates
mother-centriole-dependent centriole duplication, CCDC67/DEUP1 mediates de novo centriole amplification in
multiciliated cells
Secondary accessions: D3DND8 D3DND9 D3DNE0 Q96CR0 Q9H8F5 Q9H8N0
Alternative splicing: 4 isoforms:  Q96MT8-1   Q96MT8-2   Q96MT8-3   Q96MT8-4   

Explore the universe of human proteins at neXtProt for CEP63: NX_Q96MT8

Explore proteomics data for CEP63 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys435
  • Modification sites at PhosphoSitePlus

  • See CEP63 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001035842.1  NP_001035843.1  NP_001035859.1  NP_079456.2  

    ENSEMBL proteins: 
     ENSP00000328382   ENSP00000346432   ENSP00000424626   ENSP00000372716   ENSP00000423225  
     ENSP00000426129   ENSP00000475903   ENSP00000422685   ENSP00000426866   ENSP00000427526  
     ENSP00000336524  
    Reactome Protein details: Q96MT8

    CEP63 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CEP63

     
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    antibodies-online proteins for CEP63 (2 products) 

     
    antibodies-online peptides for CEP63

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q96MT8

    UniProtKB/Swiss-Prot: CEP63_HUMAN, Q96MT8
    Similarity: Belongs to the CEP63 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEP63_HUMAN, Q96MT8
    Function: Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole
    duplication, through centrosomal recruitment of CEP152. Also recruits CDK1 to centrosomes. Plays a role in DNA
    damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this
    leads to the inactivation of spindle assembly and delay in mitotic progression

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12812986
         
    Find genes that share ontologies with CEP63           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CEP63:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CEP63

    miRNA
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    miRTarBase miRNAs that target CEP63:
    hsa-mir-16-5p (MIRT000830), hsa-mir-15a-5p (MIRT000831)

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    Selected qRT-PCR Assays for microRNAs that regulate CEP63 (see all 32):
    hsa-miR-140-5p hsa-miR-1287 hsa-miR-495 hsa-miR-4311 hsa-miR-539 hsa-miR-137 hsa-miR-148b hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidCEP63 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CEP63_HUMAN, Q96MT8: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton,
    microtubule organizing center, centrosome, centriole. Note=Colocalizes with CEP152 in a discrete ring around the
    proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental
    centrioles and procentrioles
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus2
    golgi apparatus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole ISS--
    GO:0005813centrosome IDA14654843
    GO:0005814centriole ISS--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CEP63           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CEP63 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90


    Find genes that share SuperPaths with CEP63           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4 Reactome Pathways for CEP63
        Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition
    Loss of Nlp from mitotic centrosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CEP63
    Interactions:

        Search GeneGlobe Interaction Network for CEP63

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CEP63 (Q96MT81, 2, 3 ENSP000003365244) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MBIPQ9NS732, 3, ENSP000003244444MINT-66226 I2D: score=5 STRING: ENSP00000324444
    DISC1Q9NRI51, 3, ENSP000003555964EBI-741977,EBI-529989 I2D: score=2 STRING: ENSP00000355596
    KXD1Q9BQD32, 3, ENSP000002223074MINT-68309 I2D: score=4 STRING: ENSP00000222307
    CAMKK2Q96RR43, ENSP000003127414I2D: score=2 STRING: ENSP00000312741
    CCDC14Q49A883, ENSP000003868664I2D: score=2 STRING: ENSP00000386866
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint ISS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007067mitosis IEA--
    GO:0007099centriole replication ISS--

    Find genes that share ontologies with CEP63           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for CEP63



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CEP63 gene (4 alternative transcripts): 
    NM_001042383.1  NM_001042384.1  NM_001042400.1  NM_025180.3  

    Unigene Cluster for CEP63:

    Centrosomal protein 63kDa
    Hs.443301  [show with all ESTs]
    Unigene Representative Sequence: NM_025180
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332047 ENST00000354446(uc003eqm.3) ENST00000514412 ENST00000511574
    ENST00000504013 ENST00000383229 ENST00000512894 ENST00000513612 ENST00000606977
    ENST00000508778 ENST00000510625 ENST00000504929 ENST00000514678 ENST00000513295(uc003eqp.1)
    ENST00000337090(uc003eql.1 uc003eqn.1 uc003eqo.1)
    miRNA
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    hsa-miR-140-5p hsa-miR-1287 hsa-miR-495 hsa-miR-4311 hsa-miR-539 hsa-miR-137 hsa-miR-148b hsa-miR-105
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      QuantiTect SYBR Green Assays in human, mouse, rat CEP63
      QuantiFast Probe-based Assays in human, mouse, rat CEP63

    Additional mRNA sequence: 

    AF113697.1 AK023448.1 AK023738.1 AK054897.1 AK056465.1 AK123837.1 BC014050.2 BC068997.1 

    Selected DOTS entries (see all 25):

    DT.95277489  DT.312261  DT.100790878  DT.95112446  DT.407797  DT.100737585  DT.95277491  DT.95211940 
    DT.100790879  DT.120876611  DT.95242637  DT.100023945  DT.100734482  DT.107997  DT.100790882  DT.120876633 
    DT.120876664  DT.40207394  DT.427956  DT.91742547  DT.97768188  DT.97772295  DT.40233734  DT.95351799 

    Selected AceView cDNA sequences (see all 151):

    BM709626 BC014050 BX097171 BM504776 AI819266 AA461021 BC068997 CA429582 
    CD671086 AK056465 BE349904 BG107223 NM_025180 CB125999 AI802164 BG429591 
    CF123047 AF113697 AI417116 BU630216 AK054897 BU734108 AI436306 BI760002 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CEP63 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19
    SP1:                                                  -                             -                                         -                                 
    SP2:        -     -                                   -                             -                                         -     -     -     -               
    SP3:              -                                   -                                                                                                         
    SP4:                                                  -                             -     -                                                                     
    SP5:                                                                                -     -                                                                     


    ECgene alternative splicing isoforms for CEP63

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CEP63 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAGATAAA
    CEP63 Expression
    About this image


    CEP63 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Eye (Sensory Organs)
             Retina
     
     Testis (Reproductive System)
    CEP63 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEP63 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443301
        Custom PCR Arrays for CEP63
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CEP63 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cep631 , 5 centrosomal protein 631, 5 83.93(n)1
    81.83(a)1
      9 (54.61 cM)5
    281351  NM_001081122.11  NP_001074591.11 
     1025865785 
    chicken
    (Gallus gallus)
    Aves CEP631 centrosomal protein 63kDa 63.29(n)
    57.45(a)
      424873  NM_001168007.1  NP_001161479.1 
    lizard
    (Anolis carolinensis)
    Reptilia CEP636
    centrosomal protein 63kDa
    46(a)
    1 ↔ 1
    3(31462278-31489088)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.67282 Xenopus laevis transcribed sequence with weak similarity more 74.82(n)    BJ627584.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC056780.12   -- 72.88(n)   393574  BC056780.1 


    ENSEMBL Gene Tree for CEP63 (if available)
    TreeFam Gene Tree for CEP63 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CEP63 gene
    CCDC672  
    1 SIMAP similar gene for CEP63 using alignment to 6 protein entries:     CEP63_HUMAN (see all proteins):
    CCDC67

    Find genes that share paralogs with CEP63           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CEP63 (see all 1902)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1132777611,2
    F--131580391(+) TATTTT/CAAGGA 2 -- us2k12Minor allele frequency- C:0.03CSA WA 120
    rs766616431,2
    --131580423(+) GCTCAA/GCTTCA 2 -- us2k10--------
    rs1810257181,2
    --131580435(+) ACATCA/GTCTTG 2 -- us2k10--------
    rs1130863821,2
    F--131580448(+) TTGAGG/AATTTG 2 -- us2k13Minor allele frequency- A:0.05CSA WA 120
    rs1856103431,2
    --131580505(+) TCTCAC/GTATGT 2 -- us2k10--------
    rs1905834991,2
    C--131580591(+) GGCCGG/TGCGCG 3 -- us2k10--------
    rs1499903111,2
    --131580851(+) CTGGGA/CGACAG 4 -- us2k10--------
    rs112995161,2
    C--131580875(+) CTCGG-/AAAAAA 4 -- us2k1 trp31Minor allele frequency- A:0.00CSA 2
    rs796629751,2
    --131580886(+) AAAAAA/CAAAAA 4 -- us2k10--------
    rs1153401001,2
    F--131580926(+) TAGGAT/CAACTG 4 -- us2k11Minor allele frequency- C:0.02WA 118

    HapMap Linkage Disequilibrium report for CEP63 (134204575 - 134293859 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CEP63:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829730CNV Loss17160897
    dgv5259n71CNV Loss21882294
    esv33705CNV Loss17666407
    nsv877510CNV Gain21882294

    Human Gene Mutation Database (HGMD): CEP63
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CEP63
    DNA2.0 Custom Variant and Variant Library Synthesis for CEP63

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 614724   
    OMIM disorders: 614728  
    UniProtKB/Swiss-Prot: CEP63_HUMAN, Q96MT8
  • Seckel syndrome 6 (SCKL6) [MIM:614728]: A rare autosomal recessive disorder characterized by
    proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe
    microcephaly with a bird-headed like appearance, and mental retardation. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 3 diseases for CEP63:    
    About MalaCards
    seckel syndrome type 6    primary autosomal recessive microcephaly type 1    primary autosomal recessive microcephalies and seckel syndrome spectrum disorders


    Find genes that share disorders with CEP63           About GenesLikeMe

    Genetic Association Database (GAD): CEP63
    Human Genome Epidemiology (HuGE) Navigator: CEP63 (3 documents)

    Export disorders for CEP63 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CEP63 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with CEP63)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843)1, 2, 3 Andersen J.S....Mann M. (Nature 2003)
    2. The Cep63 paralogue Deup1 enables massive deA novo centriole biogenesis for vertebrate multiciliogenesis. (PubMed id 24240477)1, 3 Zhao H....Zhu X. (Nat. Cell Biol. 2013)
    3. Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance. (PubMed id 21406398)1, 2 Loffler H.... Kramer A. (Cancer Res. 2011)
    4. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    5. Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. (PubMed id 20846217)1, 4 Lee J.J....Hirschhorn J. (Ann. Hum. Genet. 2010)
    6. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PubMed id 19266077)1, 4 Sovio U....Jarvelin M.R. (PLoS Genet. 2009)
    7. Genome-wide association analysis identifies 20 loci that influence adult height. (PubMed id 18391952)1, 4 Weedon M.N....Frayling T.M. (Nat. Genet. 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 80254 HGNC: 25815 AceView: Cep63 Ensembl:ENSG00000182923 euGenes: HUgn80254
    ECgene: CEP63 H-InvDB: CEP63

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CEP63 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CEP63 gene:
    Search GeneIP for patents involving CEP63

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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