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Aliases for CEP57L1 Gene

Aliases for CEP57L1 Gene

  • Centrosomal Protein 57 Like 1 2 3
  • Centrosomal Protein 57kDa-Like 1 2 3 5
  • Centrosomal Protein Of 57 KDa-Related Protein 3 4
  • Centrosomal Protein 57kDa-Like Protein 1 3 4
  • Cep57-Related Protein 3 4
  • C6orf182 3 4
  • Cep57R 3 4
  • Chromosome 6 Open Reading Frame 182 2
  • BA487F23.2 3

External Ids for CEP57L1 Gene

Previous HGNC Symbols for CEP57L1 Gene

  • C6orf182

Previous GeneCards Identifiers for CEP57L1 Gene

  • GC06P109418

Summaries for CEP57L1 Gene

GeneCards Summary for CEP57L1 Gene

CEP57L1 (Centrosomal Protein 57 Like 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and gamma-tubulin binding. An important paralog of this gene is CEP57.

UniProtKB/Swiss-Prot for CEP57L1 Gene

  • Centrosomal protein which may be required for microtubule attachment to centrosomes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP57L1 Gene

Genomics for CEP57L1 Gene

Regulatory Elements for CEP57L1 Gene

Promoters for CEP57L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEP57L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEP57L1 Gene

Chromosome:
6
Start:
109,095,110 bp from pter
End:
109,163,932 bp from pter
Size:
68,823 bases
Orientation:
Plus strand

Genomic View for CEP57L1 Gene

Genes around CEP57L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP57L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP57L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP57L1 Gene

Proteins for CEP57L1 Gene

  • Protein details for CEP57L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYX8-CE57L_HUMAN
    Recommended name:
    Centrosomal protein CEP57L1
    Protein Accession:
    Q8IYX8
    Secondary Accessions:
    • G5E992

    Protein attributes for CEP57L1 Gene

    Size:
    460 amino acids
    Molecular mass:
    53649 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CEP57L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP57L1 Gene

Proteomics data for CEP57L1 Gene at MOPED

Post-translational modifications for CEP57L1 Gene

  • Ubiquitination at Lys 286
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP57L1 Gene

Domains & Families for CEP57L1 Gene

Protein Domains for CEP57L1 Gene

Suggested Antigen Peptide Sequences for CEP57L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYX8

UniProtKB/Swiss-Prot:

CE57L_HUMAN :
  • Belongs to the translokin family.
Family:
  • Belongs to the translokin family.
genes like me logo Genes that share domains with CEP57L1: view

No data available for Gene Families for CEP57L1 Gene

Function for CEP57L1 Gene

Molecular function for CEP57L1 Gene

UniProtKB/Swiss-Prot Function:
Centrosomal protein which may be required for microtubule attachment to centrosomes.

Gene Ontology (GO) - Molecular Function for CEP57L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IEA,IBA --
GO:0043015 gamma-tubulin binding IEA --
genes like me logo Genes that share ontologies with CEP57L1: view

Phenotypes for CEP57L1 Gene

genes like me logo Genes that share phenotypes with CEP57L1: view

Animal Model Products

miRNA for CEP57L1 Gene

miRTarBase miRNAs that target CEP57L1

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP57L1 Gene

Localization for CEP57L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP57L1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP57L1 Gene COMPARTMENTS Subcellular localization image for CEP57L1 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 3
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CEP57L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with CEP57L1: view

Pathways & Interactions for CEP57L1 Gene

SuperPathways for CEP57L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP57L1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEP57L1 Gene

Drugs & Compounds for CEP57L1 Gene

No Compound Related Data Available

Transcripts for CEP57L1 Gene

Unigene Clusters for CEP57L1 Gene

Centrosomal protein 57kDa-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP57L1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: - -
SP3:
SP4: -

Relevant External Links for CEP57L1 Gene

GeneLoc Exon Structure for
CEP57L1
ECgene alternative splicing isoforms for
CEP57L1

Expression for CEP57L1 Gene

mRNA expression in normal human tissues for CEP57L1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP57L1 Gene



SOURCE GeneReport for Unigene cluster for CEP57L1 Gene Hs.632616

genes like me logo Genes that share expression patterns with CEP57L1: view

Protein tissue co-expression partners for CEP57L1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP57L1 Gene

Orthologs for CEP57L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP57L1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEP57L1 35
  • 88.16 (n)
  • 83.44 (a)
CEP57L1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP57L1 35
  • 89.33 (n)
  • 83.33 (a)
CEP57L1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep57l1 35
  • 79.64 (n)
  • 74.36 (a)
Cep57l1 16
Cep57l1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CEP57L1 35
  • 99.71 (n)
  • 99.57 (a)
CEP57L1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep57l1 35
  • 76.59 (n)
  • 71.4 (a)
oppossum
(Monodelphis domestica)
Mammalia CEP57L1 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP57L1 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP57L1 35
  • 63.54 (n)
  • 50.11 (a)
CEP57L1 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP57L1 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep57l1 35
  • 56.02 (n)
  • 44.35 (a)
Str.11451 35
zebrafish
(Danio rerio)
Actinopterygii Dr.3962 35
cep57l1 36
  • 34 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3538 36
  • 27 (a)
OneToMany
Species with no ortholog for CEP57L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP57L1 Gene

ENSEMBL:
Gene Tree for CEP57L1 (if available)
TreeFam:
Gene Tree for CEP57L1 (if available)

Paralogs for CEP57L1 Gene

Paralogs for CEP57L1 Gene

Pseudogenes.org Pseudogenes for CEP57L1 Gene

genes like me logo Genes that share paralogs with CEP57L1: view

Variants for CEP57L1 Gene

Sequence variations from dbSNP and Humsavar for CEP57L1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs351733 - 109,155,232(-) ATCTT(A/G/T)TCCTG reference, missense
rs351734 -- 109,154,213(-) CAATA(A/C/T)CCTTT intron-variant
rs403911 -- 109,152,347(-) aaaag(A/T)tagct intron-variant
rs1073557 -- 109,105,779(+) GGTAC(C/G)GGTTC intron-variant
rs1011774 -- 109,147,423(-) AGCCT(C/G)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP57L1 Gene

Variant ID Type Subtype PubMed ID
esv993225 CNV Deletion 20482838
esv2732562 CNV Deletion 23290073

Variation tolerance for CEP57L1 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP57L1 Gene

HapMap Linkage Disequilibrium report
CEP57L1
Human Gene Mutation Database (HGMD)
CEP57L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP57L1 Gene

Disorders for CEP57L1 Gene

Relevant External Links for CEP57L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP57L1

No disorders were found for CEP57L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP57L1 Gene

Publications for CEP57L1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  3. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. (PMID: 25184681) Hill S.J. … Livingston D.M. (Genes Dev. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3

Products for CEP57L1 Gene

Sources for CEP57L1 Gene

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