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Aliases for CEP57L1 Gene

Aliases for CEP57L1 Gene

  • Centrosomal Protein 57 Like 1 2 3 5
  • Centrosomal Protein Of 57 KDa-Related Protein 3 4
  • Centrosomal Protein 57kDa-Like Protein 1 3 4
  • Centrosomal Protein 57kDa-Like 1 2 3
  • Cep57-Related Protein 3 4
  • C6orf182 3 4
  • Cep57R 3 4
  • Chromosome 6 Open Reading Frame 182 2
  • Centrosomal Protein CEP57L1 3
  • BA487F23.2 3

External Ids for CEP57L1 Gene

Previous HGNC Symbols for CEP57L1 Gene

  • C6orf182

Previous GeneCards Identifiers for CEP57L1 Gene

  • GC06P109418

Summaries for CEP57L1 Gene

GeneCards Summary for CEP57L1 Gene

CEP57L1 (Centrosomal Protein 57 Like 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and gamma-tubulin binding. An important paralog of this gene is CEP57.

UniProtKB/Swiss-Prot for CEP57L1 Gene

  • Centrosomal protein which may be required for microtubule attachment to centrosomes.

Additional gene information for CEP57L1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP57L1 Gene

Genomics for CEP57L1 Gene

Regulatory Elements for CEP57L1 Gene

Enhancers for CEP57L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H108732 1.6 FANTOM5 Ensembl ENCODE 10.8 -359.4 -359409 7 PKNOX1 ATF1 GATA2 ELK1 ATF7 FOS CAVIN1 YY2 TSHZ1 ZNF592 SEC63 ZBTB24 CEP57L1 FOXO3 LINC00222 PIR33619
GH06H109771 1.5 FANTOM5 Ensembl ENCODE 10.7 +677.4 677405 2 HDAC1 ARNT YY1 ZNF766 ATF7 IKZF2 CAVIN1 CEBPB NCOA1 USF2 SMPD2 ZBTB24 CEP57L1 FIG4 ENSG00000260273 CCDC162P MICAL1 CDC40 AK9 CD164
GH06H108699 1.3 Ensembl ENCODE dbSUPER 11.8 -395.3 -395310 1 NFIB ZNF195 ZIC2 ZFHX2 LCORL ZNF350 TCF7L2 MAZ ZNF571 L3MBTL2 ZBTB24 CEP57L1 SEC63 ENSG00000271730 PIR33619 LINC00222
GH06H109424 0.8 ENCODE 10.8 +329.6 329645 0 ZNF766 FOS ZBTB11 HDAC8 ZNF592 MEF2D TFDP1 ZNF589 RFX3 NR2C1 SMPD2 ENSG00000260273 ZBTB24 CEP57L1 FIG4 PIR52905 GC06P109389
GH06H109876 0.8 ENCODE 10.7 +782.3 782259 2 KLF1 ATF1 GTF2E2 BACH1 ZNF175 CEBPG PYGO2 ZNF766 GATA3 FOXK2 ZBTB24 CEP57L1 PPIL6 PIR51283 ENSG00000232311
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEP57L1 on UCSC Golden Path with GeneCards custom track

Promoters for CEP57L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000200925 -910 4401 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for CEP57L1 Gene

Chromosome:
6
Start:
109,095,110 bp from pter
End:
109,163,932 bp from pter
Size:
68,823 bases
Orientation:
Plus strand

Genomic View for CEP57L1 Gene

Genes around CEP57L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP57L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP57L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP57L1 Gene

Proteins for CEP57L1 Gene

  • Protein details for CEP57L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYX8-CE57L_HUMAN
    Recommended name:
    Centrosomal protein CEP57L1
    Protein Accession:
    Q8IYX8
    Secondary Accessions:
    • G5E992

    Protein attributes for CEP57L1 Gene

    Size:
    460 amino acids
    Molecular mass:
    53649 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CEP57L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP57L1 Gene

Post-translational modifications for CEP57L1 Gene

  • Ubiquitination at posLast=286286
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP57L1 Gene

Domains & Families for CEP57L1 Gene

Gene Families for CEP57L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CEP57L1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP57L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYX8

UniProtKB/Swiss-Prot:

CE57L_HUMAN :
  • Belongs to the translokin family.
Family:
  • Belongs to the translokin family.
genes like me logo Genes that share domains with CEP57L1: view

Function for CEP57L1 Gene

Molecular function for CEP57L1 Gene

UniProtKB/Swiss-Prot Function:
Centrosomal protein which may be required for microtubule attachment to centrosomes.

Gene Ontology (GO) - Molecular Function for CEP57L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
GO:0008017 microtubule binding IBA --
GO:0042802 identical protein binding IPI,IEA 25416956
GO:0043015 gamma-tubulin binding IEA --
genes like me logo Genes that share ontologies with CEP57L1: view
genes like me logo Genes that share phenotypes with CEP57L1: view

Animal Model Products

CRISPR Products

miRNA for CEP57L1 Gene

miRTarBase miRNAs that target CEP57L1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP57L1 Gene

Localization for CEP57L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP57L1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP57L1 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 3
nucleus 3
cytosol 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEP57L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IBA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CEP57L1: view

Pathways & Interactions for CEP57L1 Gene

SuperPathways for CEP57L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP57L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000070 mitotic sister chromatid segregation IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with CEP57L1: view

No data available for Pathways by source and SIGNOR curated interactions for CEP57L1 Gene

Drugs & Compounds for CEP57L1 Gene

No Compound Related Data Available

Transcripts for CEP57L1 Gene

Unigene Clusters for CEP57L1 Gene

Centrosomal protein 57kDa-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP57L1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: - -
SP3:
SP4: -

Relevant External Links for CEP57L1 Gene

GeneLoc Exon Structure for
CEP57L1
ECgene alternative splicing isoforms for
CEP57L1

Expression for CEP57L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEP57L1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEP57L1 Gene



Protein tissue co-expression partners for CEP57L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CEP57L1 Gene:

CEP57L1

SOURCE GeneReport for Unigene cluster for CEP57L1 Gene:

Hs.632616
genes like me logo Genes that share expression patterns with CEP57L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP57L1 Gene

Orthologs for CEP57L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP57L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP57L1 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia CEP57L1 33 34
  • 89.33 (n)
cow
(Bos Taurus)
Mammalia CEP57L1 33 34
  • 88.16 (n)
mouse
(Mus musculus)
Mammalia Cep57l1 33 16 34
  • 79.64 (n)
rat
(Rattus norvegicus)
Mammalia Cep57l1 33
  • 76.59 (n)
oppossum
(Monodelphis domestica)
Mammalia CEP57L1 34
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP57L1 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP57L1 33 34
  • 63.54 (n)
lizard
(Anolis carolinensis)
Reptilia CEP57L1 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep57l1 33
  • 56.02 (n)
Str.11451 33
zebrafish
(Danio rerio)
Actinopterygii cep57l1 34
  • 34 (a)
OneToOne
Dr.3962 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3538 34
  • 27 (a)
OneToMany
Species where no ortholog for CEP57L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP57L1 Gene

ENSEMBL:
Gene Tree for CEP57L1 (if available)
TreeFam:
Gene Tree for CEP57L1 (if available)

Paralogs for CEP57L1 Gene

Paralogs for CEP57L1 Gene

Pseudogenes.org Pseudogenes for CEP57L1 Gene

genes like me logo Genes that share paralogs with CEP57L1: view

Variants for CEP57L1 Gene

Sequence variations from dbSNP and Humsavar for CEP57L1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000025947 -- 109,098,314(+) GGCTA(A/G)TTTTG intron-variant
rs1000101727 -- 109,104,804(+) CTGAT(A/C)TTGAA intron-variant
rs1000138647 -- 109,158,340(+) AAAAT(A/T)AGCCA intron-variant
rs1000163262 -- 109,109,707(+) GTGAC(A/G)GGCCC intron-variant
rs1000181772 -- 109,138,938(+) GCAAC(C/G)TCAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CEP57L1 Gene

Variant ID Type Subtype PubMed ID
esv2732562 CNV deletion 23290073
esv993225 CNV deletion 20482838

Variation tolerance for CEP57L1 Gene

Residual Variation Intolerance Score: 73.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.81; 58.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP57L1 Gene

Human Gene Mutation Database (HGMD)
CEP57L1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP57L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP57L1 Gene

Disorders for CEP57L1 Gene

Relevant External Links for CEP57L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP57L1

No disorders were found for CEP57L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP57L1 Gene

Publications for CEP57L1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R … Iakoucheva LM (Nature communications 2014) 3 60

Products for CEP57L1 Gene

Sources for CEP57L1 Gene

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