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Aliases for CEP57L1 Gene

Aliases for CEP57L1 Gene

  • Centrosomal Protein 57kDa-Like 1 2 3
  • Centrosomal Protein Of 57 KDa-Related Protein 3 4
  • Centrosomal Protein 57kDa-Like Protein 1 3 4
  • Cep57-Related Protein 3 4
  • C6orf182 3 4
  • Cep57R 3 4
  • Chromosome 6 Open Reading Frame 182 2
  • Centrosomal Protein CEP57L1 3
  • BA487F23.2 3

External Ids for CEP57L1 Gene

Previous HGNC Symbols for CEP57L1 Gene

  • C6orf182

Previous GeneCards Identifiers for CEP57L1 Gene

  • GC06P109418

Summaries for CEP57L1 Gene

GeneCards Summary for CEP57L1 Gene

CEP57L1 (Centrosomal Protein 57kDa-Like 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and gamma-tubulin binding. An important paralog of this gene is CEP57.

UniProtKB/Swiss-Prot for CEP57L1 Gene

  • Centrosomal protein which may be required for microtubule attachment to centrosomes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP57L1 Gene

Genomics for CEP57L1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CEP57L1 Gene

Start:
109,095,110 bp from pter
End:
109,163,932 bp from pter
Size:
68,823 bases
Orientation:
Plus strand

Genomic View for CEP57L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP57L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP57L1 Gene

No data available for Regulatory Elements for CEP57L1 Gene

Proteins for CEP57L1 Gene

  • Protein details for CEP57L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYX8-CE57L_HUMAN
    Recommended name:
    Centrosomal protein CEP57L1
    Protein Accession:
    Q8IYX8
    Secondary Accessions:
    • G5E992

    Protein attributes for CEP57L1 Gene

    Size:
    460 amino acids
    Molecular mass:
    53649 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CEP57L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP57L1 Gene

Proteomics data for CEP57L1 Gene at MOPED

Post-translational modifications for CEP57L1 Gene

  • Ubiquitination at Lys286
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP57L1 Gene

Domains for CEP57L1 Gene

Protein Domains for CEP57L1 Gene

Suggested Antigen Peptide Sequences for CEP57L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYX8

UniProtKB/Swiss-Prot:

CE57L_HUMAN :
  • Q8IYX8
Family:
  • Belongs to the translokin family.
genes like me logo Genes that share domains with CEP57L1: view

No data available for Gene Families for CEP57L1 Gene

Function for CEP57L1 Gene

Molecular function for CEP57L1 Gene

UniProtKB/Swiss-Prot Function: Centrosomal protein which may be required for microtubule attachment to centrosomes.

Gene Ontology (GO) - Molecular Function for CEP57L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IEA --
GO:0042802 identical protein binding IEA --
GO:0043015 gamma-tubulin binding IEA --
genes like me logo Genes that share ontologies with CEP57L1: view

Phenotypes for CEP57L1 Gene

GenomeRNAi human phenotypes for CEP57L1:
genes like me logo Genes that share phenotypes with CEP57L1: view

Animal Model Products

CRISPR Products

miRNA for CEP57L1 Gene

miRTarBase miRNAs that target CEP57L1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEP57L1 Gene

Localization for CEP57L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP57L1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Gene Ontology (GO) - Cellular Components for CEP57L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with CEP57L1: view

No data available for Subcellular locations from COMPARTMENTS for CEP57L1 Gene

Pathways for CEP57L1 Gene

SuperPathways for CEP57L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP57L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0034453 microtubule anchoring IEA --
genes like me logo Genes that share ontologies with CEP57L1: view

No data available for Pathways by source for CEP57L1 Gene

Transcripts for CEP57L1 Gene

Unigene Clusters for CEP57L1 Gene

Centrosomal protein 57kDa-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP57L1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP57L1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: - -
SP3:
SP4: -

Relevant External Links for CEP57L1 Gene

GeneLoc Exon Structure for
CEP57L1
ECgene alternative splicing isoforms for
CEP57L1

Expression for CEP57L1 Gene

mRNA expression in normal human tissues for CEP57L1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP57L1 Gene

SOURCE GeneReport for Unigene cluster for CEP57L1 Gene Hs.632616

genes like me logo Genes that share expressions with CEP57L1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP57L1 Gene

Orthologs for CEP57L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP57L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP57L1 35
  • 99.71 (n)
  • 99.57 (a)
CEP57L1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEP57L1 35
  • 88.16 (n)
  • 83.44 (a)
CEP57L1 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP57L1 35
  • 89.33 (n)
  • 83.33 (a)
CEP57L1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep57l1 35
  • 79.64 (n)
  • 74.36 (a)
Cep57l1 16
Cep57l1 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEP57L1 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP57L1 36
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep57l1 35
  • 76.59 (n)
  • 71.4 (a)
chicken
(Gallus gallus)
Aves CEP57L1 35
  • 63.54 (n)
  • 50.11 (a)
CEP57L1 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP57L1 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep57l1 35
  • 56.02 (n)
  • 44.35 (a)
Str.11451 35
zebrafish
(Danio rerio)
Actinopterygii cep57l1 36
  • 34 (a)
OneToOne
Dr.3962 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3538 36
  • 27 (a)
OneToMany
Species with no ortholog for CEP57L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP57L1 Gene

ENSEMBL:
Gene Tree for CEP57L1 (if available)
TreeFam:
Gene Tree for CEP57L1 (if available)

Paralogs for CEP57L1 Gene

Paralogs for CEP57L1 Gene

Pseudogenes.org Pseudogenes for CEP57L1 Gene

genes like me logo Genes that share paralogs with CEP57L1: view

Variants for CEP57L1 Gene

Sequence variations from dbSNP and Humsavar for CEP57L1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs351733 - 109,155,232(-) ATCTT(G/T)TCCTG missense, reference
rs351734 -- 109,154,213(-) CAATA(C/T)CCTTT intron-variant
rs403911 -- 109,152,347(-) aaaag(A/T)tagct intron-variant
rs1011774 -- 109,147,423(-) AGCCT(C/G)CCCCA intron-variant
rs1073557 -- 109,105,779(+) GGTAC(C/G)GGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP57L1 Gene

Variant ID Type Subtype PubMed ID
esv993225 CNV Deletion 20482838
esv2732562 CNV Deletion 23290073

Relevant External Links for CEP57L1 Gene

HapMap Linkage Disequilibrium report
CEP57L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP57L1 Gene

Disorders for CEP57L1 Gene

No disorders were found for CEP57L1 Gene.

No data available for UniProtKB/Swiss-Prot for CEP57L1 Gene

Publications for CEP57L1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PMID: 17043677) Camargo L.M. … Brandon N.J. (Mol. Psychiatry 2007) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for CEP57L1 Gene

Sources for CEP57L1 Gene

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