Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEP55 Gene

protein-coding   GIFtS: 55
GCID: GC10P095247

Centrosomal Protein 55kDa

(Previous name: chromosome 10 open reading frame 3)
(Previous symbol: C10orf3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Centrosomal Protein 55kDa1 2     Chromosome 10 Open Reading Frame 31
C10orf31 2 3     CT1112
Cancer/Testis Antigen 1111 2     Centrosomal Protein Of 55 KDa2
Up-Regulated In Colon Cancer 62 3     Cep553
URCC62 3     

External Ids:    HGNC: 11611   Entrez Gene: 551652   Ensembl: ENSG000001381807   OMIM: 6100005   UniProtKB: Q53EZ43   

Export aliases for CEP55 gene to outside databases

Previous GC identifer: GC10P088884


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CEP55 Gene: 
CEP55 (centrosomal protein 55kDa) is a protein-coding gene. Diseases associated with CEP55 include colon cancer, and nasopharyngitis.

UniProtKB/Swiss-Prot: CEP55_HUMAN, Q53EZ4
Function: Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP
and TSG101 to midbody during cytokinesis

Gene Wiki entry for CEP55 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEP55 gene promoter:
         TBP   Nkx6-1   TFIID   ATF-2   CUTL1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEP55 promoter sequence
   Search SABiosciences Chromatin IP Primers for CEP55

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP55


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.33   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q24.1

CEP55 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP55 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P095247:  view genomic region     (about GC identifiers)

Start:
95,256,369 bp from pter      End:
95,288,849 bp from pter
Size:
32,481 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CEP55_HUMAN, Q53EZ4 (See protein sequence)
Recommended Name: Centrosomal protein of 55 kDa  
Size: 464 amino acids; 54178 Da
Subunit: Homodimer. Interacts (phosphorylated on Ser-425 and Ser-428) with PLK1. Interacts with AKAP9; the
interaction occurs in interphase and is lost upon mitotic entry. Interacts with PCNT; the interaction occurs in
interphase and is lost upon mitotic entry. Interacts with PDCD6IP; the interaction is direct; CEP55 binds PDCD6IP
in a 2:1 stoechiometry; PDCD6IP competes with TSG101 for the same binding site. Interacts with TSG101; TSG101
competes with PDCD6IP for the same binding site; interaction is required for cytokinesis but not for viral
budding. Interacts with MVB12A, VPS37B, VPS37C and VPS28
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm,
cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=Present at the
centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the
majority localizes to the pericentriolar material. During mitosis, loss of affinity for the centrosome at the
onset of prophase and diffusion throughout the cell. This dissociation from the centrosome is
phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears
at the cleavage furrow in late anaphase and in the midbody in cytokinesis
Sequence caution: Sequence=BAA91670.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for CEP55:
3E1R (3D)    
Secondary accessions: B2RDG8 Q32WF5 Q3MV20 Q5VY28 Q6N034 Q96H32 Q9NVS7
Alternative splicing: 2 isoforms:  Q53EZ4-1   Q53EZ4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CEP55: NX_Q53EZ4

Explore proteomics data for CEP55 at MOPED 

Post-translational modifications:

  • UniProtKB: There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the onset of mitosis,
    prior to Ser-436. Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the
    G2/M boundary. Phosphorylation at the 3 sites, Ser-425, Ser-428 and Ser-436, is required for protein function at
    the final stages of cell division to complete cytokinesis successfully
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q53EZ4

  • CEP55 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CEP55 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001120654.1  NP_060601.3  

    ENSEMBL proteins: 
     ENSP00000360540   ENSP00000389150  

    Human Recombinant Protein Products for CEP55: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CEP55
    OriGene Protein Over-expression Lysate for CEP55
    OriGene MassSpec for CEP55 
    OriGene Custom Protein Services for CEP55
    GenScript Custom Purified and Recombinant Proteins Services for CEP55
    Novus Biologicals CEP55 Protein
    Novus Biologicals CEP55 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CEP55 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--
    GO:0005814centriole IEA--
    GO:0030496midbody IDA--
    GO:0032154cleavage furrow IEA--
    GO:0045171intercellular bridge IEA--

    CEP55 for ontologies           About GeneDecksing



    CEP55 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CEP55
    GenScript Custom Superior Antibodies Services for CEP55
    Novus Biologicals CEP55 Antibodies
    Abcam antibodies for CEP55
    Cloud-Clone Corp. Antibodies for CEP55 
    ThermoFisher Antibodies for CEP55
    LSBio Antibodies in human, mouse, rat for CEP55 

    Assay Products for CEP55: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CEP55
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CEP55
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CEP55 
    Cloud-Clone Corp. CLIAs for CEP55


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR022008 EABR

    Graphical View of Domain Structure for InterPro Entry Q53EZ4

    ProtoNet protein and cluster: Q53EZ4


    CEP55 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEP55_HUMAN, Q53EZ4
    Function: Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP
    and TSG101 to midbody during cytokinesis

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    CEP55 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CEP55:
     Increased cell number in G1, s  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CEP55 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CEP55

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CEP55 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CEP55 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEP55
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CEP55 (see all 13):
    hsa-miR-3163 hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-144 hsa-miR-19b hsa-miR-454 hsa-miR-4295
    SwitchGear 3'UTR luciferase reporter plasmidCEP55 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CEP55
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEP55

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CEP55
    Sirion Biotech Customized adenovirus for overexpression of CEP55

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CEP55 (see all 13)
    OriGene ORF clones in mouse, rat for CEP55
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CEP55 (NM_018131)
    Sino Biological Human cDNA Clone for CEP55
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEP55
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP55
    Sirion Biotech Customized lentivirus for stable overexpression of CEP55 
                         Customized lentivirus expression plasmids for stable overexpression of CEP55 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CEP55
    Search LifeMap BioReagents cell lines for CEP55
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP55


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEP55

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/26 Interacting proteins for CEP55 (Q53EZ41, 2, 3 ENSP000003605404) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998161, 2, 3, ENSP000002519684EBI-747776,EBI-346882 MINT-6173601 MINT-6169549 MINT-6173584 MINT-6173720 MINT-6175155 MINT-6173676 MINT-6173387 MINT-6173737 MINT-6173542 I2D: score=5 STRING: ENSP00000251968
    PDCD6IPQ8WUM42, 3, ENSP000003073874MINT-6173613 MINT-6173720 MINT-6173792 MINT-6175173 MINT-6173644 MINT-6169566 MINT-6173415 MINT-6173556 I2D: score=2 STRING: ENSP00000307387
    VPS37CA5D8V62, 3, ENSP000003017654STRING: ENSP00000301765 MINT-6173464 MINT-6173613 I2D: score=2 
    VPS37DQ86XT22, 3, ENSP000003204164MINT-6173476 I2D: score=2 STRING: ENSP00000320416
    HGSO149642, 3, ENSP000003312014MINT-6173401 MINT-6173438 I2D: score=2 STRING: ENSP00000331201
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis ----
    GO:0007067mitosis IEA--
    GO:0051301cell division IEA--

    CEP55 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEP55

    Search CenterWatch for drugs/clinical trials and news about CEP55

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CEP55 gene (2 alternative transcripts): 
    NM_001127182.1  NM_018131.4  

    Unigene Cluster for CEP55:

    Centrosomal protein 55kDa
    Hs.14559  [show with all ESTs]
    Unigene Representative Sequence: NM_018131
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371485(uc009xug.3 uc001kiq.4) ENST00000445435 ENST00000496302

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEP55
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate CEP55 (see all 13):
    hsa-miR-3163 hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-144 hsa-miR-19b hsa-miR-454 hsa-miR-4295
    SwitchGear 3'UTR luciferase reporter plasmidCEP55 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CEP55
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEP55
    Clone
    Products:
         
    OriGene clones in human, mouse for CEP55 (see all 13)
    OriGene ORF clones in mouse, rat for CEP55
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CEP55 (NM_018131)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEP55
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP55
    Sirion Biotech Customized lentivirus for stable overexpression of CEP55 
                         Customized lentivirus expression plasmids for stable overexpression of CEP55 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CEP55
    OriGene qSTAR qPCR primer pairs in human, mouse for CEP55
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CEP55
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP55
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP55

    Additional mRNA sequence: 

    AB091343.1 AK001402.1 AK223495.1 AK315536.1 AY788918.1 BC008947.2 BX640718.1 

    5 DOTS entries:

    DT.213196  DT.91667579  DT.91740789  DT.102823842  DT.121263562 

    24/141 AceView cDNA sequences (see all 141):

    AA314512 AI696847 AI632234 BQ775394 BF980955 AA653563 CR617073 AI674163 
    BQ775946 CR623893 BU632822 C00145 AV715532 BU620633 AI280346 AA960972 
    CA428793 CA417913 CR604604 AA806630 BU619881 CA429940 CA419337 BI829150 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CEP55    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                                                        
    SP2:                    -                                                   
    SP3:                    -     -                                             
    SP4:                          -                                             


    ECgene alternative splicing isoforms for CEP55

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEP55 expression in normal human tissues (normalized intensities)      CEP55 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTACCACTG
    CEP55 Expression
    About this image


    CEP55 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Umbilical cord blood-derived mesenchymal stem cells
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   
     
     Mesenchymal Stem Cells
             Umbilical cord blood-derived mesenchymal stem cells
             Human Umbilical Mesenchymal Stem Cells (HUMSC)   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Human Intestinal Smooth Muscle Cells (HISMC)   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem progenitor F15

    See CEP55 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CEP55

    SOURCE GeneReport for Unigene cluster: Hs.14559

    UniProtKB/Swiss-Prot: CEP55_HUMAN, Q53EZ4
    Tissue specificity: Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate
    levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the
    digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain

        SABiosciences Custom PCR Arrays for CEP55
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CEP55
    OriGene qSTAR qPCR primer pairs in human, mouse for CEP55
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CEP55
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP55
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP55
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP55

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CEP55 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cep551 , 5 centrosomal protein 551, 5 80.19(n)1
    75.49(a)1
      19 (32.69 cM)5
    741071  NM_028760.21  NP_083036.21 
     380550255 
    chicken
    (Gallus gallus)
    Aves CEP551 centrosomal protein 55kDa 62.43(n)
    53.95(a)
      423804  XM_421675.2  XP_421675.1 
    lizard
    (Anolis carolinensis)
    Reptilia CEP556
    Uncharacterized protein
    49(a)
    1 ↔ 1
    GL343219.1(1971250-1998301)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL877898.22   -- 79.28(n)    AL877898.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cep55l1 centrosomal protein 55 like 53.59(n)
    41.37(a)
      553800  NM_001020762.1  NP_001018598.1 


    ENSEMBL Gene Tree for CEP55 (if available)
    TreeFam Gene Tree for CEP55 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/761 SNPs in CEP55 are shown (see all 761)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0229964
    ----see VAR_0229962 T A mis40--------
    rs728209131,2
    C--95254428(+) CAGGGC/TGACCT 2 -- us2k10--------
    rs1169999801,2
    C,F--95254661(+) TAATTT/GTGCCC 2 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1864524501,2
    --95254780(+) GAGCTC/TCTTGG 2 -- us2k10--------
    rs728209161,2
    C--95254938(+) TTACTA/GAATGT 2 -- us2k10--------
    rs1827532651,2
    --95255280(+) ATTAAA/GTCTAG 2 -- us2k10--------
    rs1874088381,2
    --95255376(+) CCAGCG/TAGTTT 2 -- us2k10--------
    rs1467990911,2
    --95255520(+) AGTCTA/GGTCTG 2 -- us2k10--------
    rs79045421,2
    C,F,A,H--95255581(+) TCTCAG/TCTCTC 2 -- us2k1 tfbs324Minor allele frequency- T:0.25NS EA NA WA CSA 2348
    rs1922019961,2
    --95255658(+) GGAAGA/GATCAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CEP55 (95256369 - 95288849 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CEP55:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv825521CNV Loss20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CEP55
    DNA2.0 Custom Variant and Variant Library Synthesis for CEP55

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610000    OMIM disorders: --

    4 diseases for CEP55:    About MalaCards
    colon cancer    nasopharyngitis    alzheimer's disease    squamous cell carcinoma


    CEP55 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CEP55
    Human Genome Epidemiology (HuGE) Navigator: CEP55 (1 document)

    Export disorders for CEP55 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEP55 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with CEP55)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. (PubMed id 16198290)1, 2, 3 Fabbro M.... Khanna K.K. (2005)
    2. The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody. (PubMed id 16406728)1, 2, 9 Martinez-Garay I.... Kutsche K. (2006)
    3. Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. (PubMed id 18948538)1, 2 Lee H.H.... Hurley J.H. (2008)
    4. Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery. (PubMed id 17556548)1, 2 Carlton J.G. and Martin-Serrano J. (2007)
    5. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PubMed id 17853893)1, 2 Morita E....Sundquist W.I. (2007)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55165 HGNC: 1161 AceView: C10orf3 Ensembl:ENSG00000138180 euGenes: HUgn55165
    ECgene: CEP55 H-InvDB: CEP55

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEP55 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CEP55 gene:
    Search GeneIP for patents involving CEP55

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CEP55  
     OriGene qPCR primer pairs and template standards for CEP55   OriGene Protein Over-expression Lysate for CEP55  
     OriGene MassSpec something-or-other for CEP55   OriGene clones in human, mouse for CEP55  
     OriGene qSTAR qPCR primer pairs in human, mouse for CEP55   OriGene Purified Protein for CEP55  
     OriGene ORF clones in mouse, rat for CEP55   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CEP55   OriGene Custom Protein Services for CEP55  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CEP55
     QIAGEN SeqTarget long-range PCR primers for resequencing CEP55
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP55
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEP55
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP55
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP55
     GenScript Custom Purified and Recombinant Proteins Services for CEP55 GenScript cDNA clones with any tag delivered in your preferred vector for CEP55
     GenScript Custom Assay Services for CEP55 GenScript Custom Superior Antibodies Services for CEP55
     GenScript Custom overexpressing Cell Line Services for CEP55 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CEP55 promoter
     Search Chromatin IP Primers for CEP55
     RT2 qPCR Primer Assay in human, mouse, rat CEP55
     Search GNC Networks for CEP55
     SABiosciences Custom PCR Arrays for CEP55
     Search Tocris compounds for CEP55
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CEP55
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CEP55 antibodies
     CEP55 proteins
     CEP55 lysates
     Antibodies for CEP55
     See all of Abcam's Antibodies, Kits and Proteins for CEP55
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CEP55
     Antibodies for CEP55
     ELISAs for CEP55
     CLIAs for CEP55
     Search LifeMap BioReagents cell lines for CEP55
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP55
     SwitchGear 3'UTR luciferase reporter plasmids for CEP55
     SwitchGear Promoter luciferase reporter plasmids for CEP55
     ThermoFisher Antibodies for CEP55
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP55
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CEP55
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CEP55
    Customized:
     lentivirus for stable overexpression of CEP55
     lentivirus expression plasmids for stable overexpression of CEP55
     adenovirus for overexpression of CEP55
     LSBio Antibodies in human, mouse, rat for CEP55
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CEP55 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4