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Aliases for CEP55 Gene

Aliases for CEP55 Gene

  • Centrosomal Protein 55 2 3
  • Centrosomal Protein 55kDa 2 3 5
  • Up-Regulated In Colon Cancer 6 3 4
  • Cancer/Testis Antigen 111 2 3
  • C10orf3 3 4
  • URCC6 3 4
  • Chromosome 10 Open Reading Frame 3 2
  • CT111 3
  • Cep55 4

External Ids for CEP55 Gene

Previous HGNC Symbols for CEP55 Gene

  • C10orf3

Previous GeneCards Identifiers for CEP55 Gene

  • GC10P095247
  • GC10P088884

Summaries for CEP55 Gene

GeneCards Summary for CEP55 Gene

CEP55 (Centrosomal Protein 55) is a Protein Coding gene. Among its related pathways are DNA Damage and Cytoskeletal Signaling.

UniProtKB/Swiss-Prot for CEP55 Gene

  • Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.

Gene Wiki entry for CEP55 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP55 Gene

Genomics for CEP55 Gene

Regulatory Elements for CEP55 Gene

Enhancers for CEP55 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CEP55 on UCSC Golden Path with GeneCards custom track

Promoters for CEP55 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEP55 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEP55 Gene

93,496,612 bp from pter
93,529,094 bp from pter
32,483 bases
Plus strand

Genomic View for CEP55 Gene

Genes around CEP55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP55 Gene

Proteins for CEP55 Gene

  • Protein details for CEP55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Centrosomal protein of 55 kDa
    Protein Accession:
    Secondary Accessions:
    • B2RDG8
    • Q32WF5
    • Q3MV20
    • Q5VY28
    • Q6N034
    • Q96H32
    • Q9NVS7

    Protein attributes for CEP55 Gene

    464 amino acids
    Molecular mass:
    54178 Da
    Quaternary structure:
    • Homodimer. Interacts (phosphorylated on Ser-425 and Ser-428) with PLK1. Interacts with AKAP9; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PCNT; the interaction occurs in interphase and is lost upon mitotic entry. Interacts with PDCD6IP; the interaction is direct; CEP55 binds PDCD6IP in a 2:1 stoechiometry; PDCD6IP competes with TSG101 for the same binding site. Interacts with TSG101; TSG101 competes with PDCD6IP for the same binding site; interaction is required for cytokinesis but not for viral budding. Interacts with MVB12A, VPS37B, VPS37C and VPS28.
    • Sequence=BAA91670.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEP55 Gene

    Alternative splice isoforms for CEP55 Gene


neXtProt entry for CEP55 Gene

Proteomics data for CEP55 Gene at MOPED

Post-translational modifications for CEP55 Gene

  • There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the onset of mitosis, prior to Ser-436. Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-425, Ser-428 and Ser-436, is required for protein function at the final stages of cell division to complete cytokinesis successfully.
  • Ubiquitination at Lys 129, Lys 145, Lys 180, Lys 196, Lys 222, Lys 233, Lys 341, Lys 367, Lys 398, and Lys 442
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP55 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CEP55 (CEP55)
  • Abcam antibodies for CEP55

No data available for DME Specific Peptides for CEP55 Gene

Domains & Families for CEP55 Gene

Protein Domains for CEP55 Gene


Suggested Antigen Peptide Sequences for CEP55 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEP55: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CEP55 Gene

Function for CEP55 Gene

Molecular function for CEP55 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP and TSG101 to midbody during cytokinesis.
genes like me logo Genes that share phenotypes with CEP55: view

Animal Model Products

miRNA for CEP55 Gene

miRTarBase miRNAs that target CEP55

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP55 Gene

Localization for CEP55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP55 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loss of affinity for the centrosome at the onset of prophase and diffusion throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis.

Subcellular locations from

Jensen Localization Image for CEP55 Gene COMPARTMENTS Subcellular localization image for CEP55 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
endosome 2
extracellular 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CEP55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005814 centriole IEA --
GO:0030496 midbody IEA,IDA 20186884
genes like me logo Genes that share ontologies with CEP55: view

Pathways & Interactions for CEP55 Gene

SuperPathways for CEP55 Gene

genes like me logo Genes that share pathways with CEP55: view

Pathways by source for CEP55 Gene

2 Cell Signaling Technology pathways for CEP55 Gene

SIGNOR curated interactions for CEP55 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CEP55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0007080 NOT mitotic metaphase plate congression IMP 20616062
genes like me logo Genes that share ontologies with CEP55: view

Drugs & Compounds for CEP55 Gene

No Compound Related Data Available

Transcripts for CEP55 Gene

Unigene Clusters for CEP55 Gene

Centrosomal protein 55kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP55 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7
SP2: -
SP3: - -
SP4: -

Relevant External Links for CEP55 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CEP55 Gene

mRNA expression in normal human tissues for CEP55 Gene

mRNA differential expression in normal tissues according to GTEx for CEP55 Gene

This gene is overexpressed in Testis (x5.7) and Esophagus - Mucosa (x4.4).

Protein differential expression in normal tissues from HIPED for CEP55 Gene

This gene is overexpressed in Plasma (44.7) and Testis (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP55 Gene

SOURCE GeneReport for Unigene cluster for CEP55 Gene Hs.14559

mRNA Expression by UniProt/SwissProt for CEP55 Gene

Tissue specificity: Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain.
genes like me logo Genes that share expression patterns with CEP55: view

Protein tissue co-expression partners for CEP55 Gene

- Elite partner

Primer Products

Orthologs for CEP55 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP55 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CEP55 35
  • 88.41 (n)
  • 85.75 (a)
CEP55 36
  • 85 (a)
(Canis familiaris)
Mammalia CEP55 35
  • 90.5 (n)
  • 86.58 (a)
CEP55 36
  • 87 (a)
(Mus musculus)
Mammalia Cep55 35
  • 80.16 (n)
  • 75.54 (a)
Cep55 16
Cep55 36
  • 75 (a)
(Pan troglodytes)
Mammalia CEP55 35
  • 99.57 (n)
  • 99.57 (a)
CEP55 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Cep55 35
  • 81.1 (n)
  • 76.62 (a)
(Monodelphis domestica)
Mammalia CEP55 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia CEP55 36
  • 54 (a)
(Gallus gallus)
Aves CEP55 35
  • 62.28 (n)
  • 53.95 (a)
CEP55 36
  • 51 (a)
(Anolis carolinensis)
Reptilia CEP55 36
  • 50 (a)
(Danio rerio)
Actinopterygii cep55l 35
  • 53.43 (n)
  • 41.37 (a)
cep55l 36
  • 39 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9181 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4811 36
  • 20 (a)
Species with no ortholog for CEP55:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP55 Gene

Gene Tree for CEP55 (if available)
Gene Tree for CEP55 (if available)

Paralogs for CEP55 Gene

No data available for Paralogs for CEP55 Gene

Variants for CEP55 Gene

Sequence variations from dbSNP and Humsavar for CEP55 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs7080916 - 93,503,224(+) CTACC(A/G)CATTG reference, missense, utr-variant-5-prime
rs2293277 - 93,519,749(+) ATTGC(A/T)TGTAA reference, missense
rs3740370 - 93,500,222(-) AGTCT(C/G)TGTCT intron-variant, reference, missense, utr-variant-5-prime
rs7072484 - 93,516,961(+) AGAAA(C/T)GTTAC reference, missense
rs1815710 -- 93,506,715(+) GGCAC(A/C)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP55 Gene

Variant ID Type Subtype PubMed ID
nsv825521 CNV Loss 20364138

Variation tolerance for CEP55 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.64; 89.13% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CEP55 Gene

Disorders for CEP55 Gene

Relevant External Links for CEP55

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CEP55 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP55 Gene

Publications for CEP55 Gene

  1. Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. (PMID: 16198290) Fabbro M. … Khanna K.K. (Dev. Cell 2005) 2 3 4 67
  2. The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody. (PMID: 16406728) Martinez-Garay I. … Kutsche K. (Genomics 2006) 3 23
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Upregulation of FLJ10540, a PI3K-association protein, in rostral ventrolateral medulla impairs brain stem cardiovascular regulation during mevinphos intoxication. (PMID: 25449601) Tsai C.Y. … Chan S.H. (Biochem. Pharmacol. 2015) 3
  5. Myotubularin-related proteins 3 and 4 interact with polo-like kinase 1 and centrosomal protein of 55 kDa to ensure proper abscission. (PMID: 25659891) St-Denis N. … Gingras A.C. (Mol. Cell Proteomics 2015) 3

Products for CEP55 Gene

Sources for CEP55 Gene