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CEP55 Gene

protein-coding   GIFtS: 56
GCID: GC10P095247

Centrosomal Protein 55kDa

(Previous name: chromosome 10 open reading frame 3)
(Previous symbol: C10orf3)
  See CEP55-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centrosomal Protein 55kDa1 2     Chromosome 10 Open Reading Frame 31
C10orf31 2 3     CT1112
Cancer/Testis Antigen 1111 2     Centrosomal Protein Of 55 KDa2
Up-Regulated In Colon Cancer 62 3     Cep553
URCC62 3     

External Ids:    HGNC: 11611   Entrez Gene: 551652   Ensembl: ENSG000001381807   OMIM: 6100005   UniProtKB: Q53EZ43   

Export aliases for CEP55 gene to outside databases

Previous GC identifer: GC10P088884


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CEP55 Gene:
CEP55 (centrosomal protein 55kDa) is a protein-coding gene. Diseases associated with CEP55 include colon cancer.

UniProtKB/Swiss-Prot: CEP55_HUMAN, Q53EZ4
Function: Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP
and TSG101 to midbody during cytokinesis

Gene Wiki entry for CEP55 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CEP55 gene promoter:
         TBP   Nkx6-1   TFIID   ATF-2   CUTL1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEP55 promoter sequence
   Search Chromatin IP Primers for CEP55

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEP55


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23.33   Ensembl cytogenetic band:  10q23.33   HGNC cytogenetic band: 10q24.1

CEP55 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP55 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P095247:  view genomic region     (about GC identifiers)

Start:
95,256,369 bp from pter      End:
95,288,849 bp from pter
Size:
32,481 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CEP55_HUMAN, Q53EZ4 (See protein sequence)
Recommended Name: Centrosomal protein of 55 kDa  
Size: 464 amino acids; 54178 Da
Subunit: Homodimer. Interacts (phosphorylated on Ser-425 and Ser-428) with PLK1. Interacts with AKAP9; the
interaction occurs in interphase and is lost upon mitotic entry. Interacts with PCNT; the interaction occurs in
interphase and is lost upon mitotic entry. Interacts with PDCD6IP; the interaction is direct; CEP55 binds PDCD6IP
in a 2:1 stoechiometry; PDCD6IP competes with TSG101 for the same binding site. Interacts with TSG101; TSG101
competes with PDCD6IP for the same binding site; interaction is required for cytokinesis but not for viral
budding. Interacts with MVB12A, VPS37B, VPS37C and VPS28
Sequence caution: Sequence=BAA91670.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for CEP55:
3E1R (3D)    
Secondary accessions: B2RDG8 Q32WF5 Q3MV20 Q5VY28 Q6N034 Q96H32 Q9NVS7
Alternative splicing: 2 isoforms:  Q53EZ4-1   Q53EZ4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CEP55: NX_Q53EZ4

Explore proteomics data for CEP55 at MOPED

Post-translational modifications: 

  • There is a hierachy of phosphorylation, where both Ser-425 and Ser-428 are phosphorylated at the onset of mitosis,
    prior to Ser-436. Phosphorylation at Ser-425 and Ser-428 is required for dissociation from the centrosome at the
    G2/M boundary. Phosphorylation at the 3 sites, Ser-425, Ser-428 and Ser-436, is required for protein function at
    the final stages of cell division to complete cytokinesis successfully1
  • Ubiquitination2 at Lys129, Lys145, Lys180, Lys196, Lys222, Lys233, Lys341, Lys367, Lys398, Lys427,
                                 Lys442
  • Modification sites at PhosphoSitePlus

  • See CEP55 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001120654.1  NP_060601.3  

    ENSEMBL proteins: 
     ENSP00000360540   ENSP00000389150  

    CEP55 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CEP55

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR022008 EABR

    Graphical View of Domain Structure for InterPro Entry Q53EZ4

    ProtoNet protein and cluster: Q53EZ4


    Find genes that share domains with CEP55           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEP55_HUMAN, Q53EZ4
    Function: Plays a role in mitotic exit and cytokinesis. Not required for microtubule nucleation. Recruits PDCD6IP
    and TSG101 to midbody during cytokinesis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    Find genes that share ontologies with CEP55           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CEP55:
     Increased cell number in G1, s  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEP55
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CEP55

    miRNA
    Products:
        
    miRTarBase miRNAs that target CEP55:
    hsa-mir-1229-3p (MIRT036269), hsa-mir-192-5p (MIRT026277), hsa-mir-215-5p (MIRT024828), hsa-mir-27a-3p (MIRT050017), hsa-mir-155-5p (MIRT020611), hsa-mir-103a-3p (MIRT026998), hsa-mir-16-5p (MIRT031510)

    Block miRNA regulation of human, mouse, rat CEP55 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CEP55 (see all 13):
    hsa-miR-3163 hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-144 hsa-miR-19b hsa-miR-454 hsa-miR-4295
    SwitchGear 3'UTR luciferase reporter plasmidCEP55 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CEP55
    Predesigned siRNA for gene silencing in human, mouse, rat CEP55

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    GenScript: all cDNA clones in your preferred vector (see all 2): CEP55 (NM_018131)
    Sino Biological Human cDNA Clone for CEP55
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEP55
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP55

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP55


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CEP55_HUMAN, Q53EZ4: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm,
    cytoskeleton, microtubule organizing center, centrosome. Cleavage furrow. Midbody. Note=Present at the
    centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the
    majority localizes to the pericentriolar material. During mitosis, loss of affinity for the centrosome at the
    onset of prophase and diffusion throughout the cell. This dissociation from the centrosome is
    phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears
    at the cleavage furrow in late anaphase and in the midbody in cytokinesis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    cytosol2
    extracellular2
    endosome1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--
    GO:0005814centriole IEA--
    GO:0030496midbody IDA--
    GO:0032154cleavage furrow IEA--
    GO:0045171intercellular bridge IEA--

    Find genes that share ontologies with CEP55           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CEP55
    Interactions:

        Search GeneGlobe Interaction Network for CEP55

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for CEP55 (Q53EZ41, 2, 3 ENSP000003605404) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSG101Q998161, 2, 3, ENSP000002519684EBI-747776,EBI-346882 MINT-6173601 MINT-6173584 MINT-6169549 MINT-6173720 MINT-6175155 MINT-6173676 MINT-6173387 MINT-6173737 MINT-6173542 I2D: score=5 STRING: ENSP00000251968
    PDCD6IPQ8WUM41, 2, 3, ENSP000003073874EBI-747776,EBI-7603917 MINT-6173613 MINT-6173720 MINT-6173792 MINT-6175173 MINT-6173644 MINT-6169566 MINT-6173415 MINT-6173556 I2D: score=2 STRING: ENSP00000307387
    VPS37CA5D8V62, 3, ENSP000003017654STRING: ENSP00000301765 MINT-6173464 MINT-6173613 I2D: score=2 
    VPS37DQ86XT22, 3, ENSP000003204164MINT-6173476 I2D: score=2 STRING: ENSP00000320416
    HGSO149642, 3, ENSP000003312014MINT-6173401 MINT-6173438 I2D: score=2 STRING: ENSP00000331201
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281mitotic cytokinesis IGI19638580
    GO:0007067mitosis IEA--
    GO:0045184establishment of protein localization IMP--

    Find genes that share ontologies with CEP55           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CEP55



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CEP55 gene (2 alternative transcripts): 
    NM_001127182.1  NM_018131.4  

    Unigene Cluster for CEP55:

    Centrosomal protein 55kDa
    Hs.14559  [show with all ESTs]
    Unigene Representative Sequence: NM_018131
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371485(uc009xug.3 uc001kiq.4) ENST00000445435 ENST00000496302

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CEP55 (see all 13):
    hsa-miR-3163 hsa-miR-301b hsa-miR-301a hsa-miR-3666 hsa-miR-144 hsa-miR-19b hsa-miR-454 hsa-miR-4295
    SwitchGear 3'UTR luciferase reporter plasmidCEP55 3' UTR sequence
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CEP55
      QuantiTect SYBR Green Assays in human, mouse, rat CEP55
      QuantiFast Probe-based Assays in human, mouse, rat CEP55

    Additional mRNA sequence: 

    AB091343.1 AK001402.1 AK223495.1 AK315536.1 AY788918.1 BC008947.2 BX640718.1 

    5 DOTS entries:

    DT.213196  DT.91667579  DT.91740789  DT.102823842  DT.121263562 

    Selected AceView cDNA sequences (see all 141):

    BQ775394 CR617073 AI632234 AA314512 CR623893 BF980955 BI829150 AA653563 
    AA960972 BU632822 C00145 BU619881 CR604604 AA806158 CB125753 AI696847 
    AI674163 CA419337 BQ775946 CA428793 CA417913 CA429940 AI280346 AV715532 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CEP55    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7
    SP1:                                                                        
    SP2:                    -                                                   
    SP3:                    -     -                                             
    SP4:                          -                                             


    ECgene alternative splicing isoforms for CEP55

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CEP55 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTACCACTG
    CEP55 Expression
    About this image


    CEP55 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Blood (Hematopoietic System)
             Umbilical cord blood-derived mesenchymal stem cells
    CEP55 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEP55 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.14559

    UniProtKB/Swiss-Prot: CEP55_HUMAN, Q53EZ4
    Tissue specificity: Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate
    levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the
    digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP55

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CEP55 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cep551 , 5 centrosomal protein 551, 5 80.16(n)1
    75.54(a)1
      19 (32.69 cM)5
    741071  NM_028293.11  NP_082569.11 
     380550255 
    chicken
    (Gallus gallus)
    Aves CEP551 centrosomal protein 55kDa 62.28(n)
    53.95(a)
      423804  XM_421675.3  XP_421675.1 
    lizard
    (Anolis carolinensis)
    Reptilia CEP556
    centrosomal protein 55kDa
    50(a)
    1 ↔ 1
    GL343219.1(1971250-1998301)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL877898.22   -- 79.28(n)    AL877898.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cep55l1 centrosomal protein 55 like 53.43(n)
    41.37(a)
      553800  NM_001020762.1  NP_001018598.1 


    ENSEMBL Gene Tree for CEP55 (if available)
    TreeFam Gene Tree for CEP55 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CEP55 (see all 761)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs728209131,2
    C--95254428(+) CAGGGC/TGACCT 2 -- us2k10--------
    rs1169999801,2
    C,F--95254661(+) TAATTT/GTGCCC 2 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1864524501,2
    --95254780(+) GAGCTC/TCTTGG 2 -- us2k10--------
    rs728209161,2
    C--95254938(+) TTACTA/GAATGT 2 -- us2k10--------
    rs1827532651,2
    --95255280(+) ATTAAA/GTCTAG 2 -- us2k10--------
    rs1874088381,2
    --95255376(+) CCAGCG/TAGTTT 2 -- us2k10--------
    rs1467990911,2
    --95255520(+) AGTCTA/GGTCTG 2 -- us2k10--------
    rs79045421,2
    C,F,A,H--95255581(+) TCTCAG/TCTCTC 2 -- us2k1 tfbs324Minor allele frequency- T:0.25NS EA NA WA CSA 2348
    rs1922019961,2
    --95255658(+) GGAAGA/GATCAC 2 -- us2k10--------
    rs1832239611,2
    --95255984(+) GGAGAA/GTCTAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CEP55 (95256369 - 95288849 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CEP55:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv825521CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CEP55
    DNA2.0 Custom Variant and Variant Library Synthesis for CEP55

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610000    OMIM disorders: --

    1 disease for CEP55:    
    About MalaCards
    colon cancer


    Find genes that share disorders with CEP55           About GenesLikeMe

    Genetic Association Database (GAD): CEP55
    Human Genome Epidemiology (HuGE) Navigator: CEP55 (1 document)

    Export disorders for CEP55 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CEP55 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with CEP55)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. (PubMed id 16198290)1, 2, 3 Fabbro M.... Khanna K.K. (Dev. Cell 2005)
    2. The novel centrosomal associated protein CEP55 is present in the spindle midzone and the midbody. (PubMed id 16406728)1, 2, 9 Martinez-Garay I.... Kutsche K. (Genomics 2006)
    3. Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. (PubMed id 18948538)1, 2 Lee H.H.... Hurley J.H. (Science 2008)
    4. Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery. (PubMed id 17556548)1, 2 Carlton J.G. and Martin-Serrano J. (Science 2007)
    5. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PubMed id 17853893)1, 2 Morita E.... Sundquist W.I. (EMBO J. 2007)
    6. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55165 HGNC: 1161 AceView: C10orf3 Ensembl:ENSG00000138180 euGenes: HUgn55165
    ECgene: CEP55 H-InvDB: CEP55

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CEP55 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CEP55 gene:
    Search GeneIP for patents involving CEP55

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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