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Aliases for CEP350 Gene

Aliases for CEP350 Gene

  • Centrosomal Protein 350kDa 2 3
  • CAP350 3 4
  • Centrosome-Associated Protein Of 350 KDa 4
  • Centrosome Associated Protein 350 2
  • Centrosome-Associated Protein 350 3
  • KIAA0480 4
  • Cep350 4
  • GM133 3

External Ids for CEP350 Gene

Previous GeneCards Identifiers for CEP350 Gene

  • GC01P178190
  • GC01P151155

Summaries for CEP350 Gene

Entrez Gene Summary for CEP350 Gene

  • The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CEP350 Gene

CEP350 (Centrosomal Protein 350kDa) is a Protein Coding gene. An important paralog of this gene is CLIP4.

UniProtKB/Swiss-Prot for CEP350 Gene

  • Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity.

Gene Wiki entry for CEP350 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP350 Gene

Genomics for CEP350 Gene

Regulatory Elements for CEP350 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CEP350 Gene

Start:
179,954,738 bp from pter
End:
180,114,880 bp from pter
Size:
160,143 bases
Orientation:
Plus strand

Genomic View for CEP350 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP350 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP350 Gene

Proteins for CEP350 Gene

  • Protein details for CEP350 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VT06-CE350_HUMAN
    Recommended name:
    Centrosome-associated protein 350
    Protein Accession:
    Q5VT06
    Secondary Accessions:
    • O75068
    • Q8TDK3
    • Q8WY20

    Protein attributes for CEP350 Gene

    Size:
    3117 amino acids
    Molecular mass:
    350930 Da
    Quaternary structure:
    • Part of a ternary complex composed of SASS6, CENPJ and CEP350. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with FGFR1OP via its C-terminus. Interacts with NR1H3, PPARA, PPARD and PPARG. Interacts directly with microtubules. Interacts with the fusion protein FGFR1OP-FGFR1, and by doing so recruits and activates PI3K and PLC-gamma. Interacts with CYLD (PubMed:25134987).

    Three dimensional structures from OCA and Proteopedia for CEP350 Gene

neXtProt entry for CEP350 Gene

Proteomics data for CEP350 Gene at MOPED

Post-translational modifications for CEP350 Gene

  • Phosphorylated during mitosis.
  • Ubiquitination at Lys250, Lys663, Lys686, Lys829, and Lys1318
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP350 Gene

Domains for CEP350 Gene

Protein Domains for CEP350 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5VT06

UniProtKB/Swiss-Prot:

CE350_HUMAN :
  • Q5VT06
Domain:
  • Contains 1 CAP-Gly domain.
genes like me logo Genes that share domains with CEP350: view

No data available for Gene Families for CEP350 Gene

Function for CEP350 Gene

Molecular function for CEP350 Gene

UniProtKB/Swiss-Prot Function: Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity.

Gene Ontology (GO) - Molecular Function for CEP350 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25134987
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with CEP350: view

Animal Model Products

CRISPR Products

miRNA for CEP350 Gene

miRTarBase miRNAs that target CEP350

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP350

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEP350 Gene

Localization for CEP350 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP350 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus. Note=Associated with mitotic spindles. Nuclear, in discrete foci. Associated with intermediate filaments. Also present in the pericentrosomal area.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP350 Gene COMPARTMENTS Subcellular localization image for CEP350 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CEP350 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with CEP350: view

Pathways for CEP350 Gene

SuperPathways for CEP350 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP350 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034453 microtubule anchoring IEA --
genes like me logo Genes that share ontologies with CEP350: view

No data available for Pathways by source for CEP350 Gene

Transcripts for CEP350 Gene

Unigene Clusters for CEP350 Gene

Centrosomal protein 350kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP350

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CEP350
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP350 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1:
SP2: - - - - - - - - -
SP3:
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34a · 34b · 34c · 34d ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^
SP1: - - - - - - -
SP2: -
SP3: - - - - - -
SP4:
SP5:
SP6: -
SP7: -
SP8: - -
SP9:
SP10: -
SP11:

ExUns: 41 ^ 42 ^ 43 ^ 44 ^ 45
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for CEP350 Gene

GeneLoc Exon Structure for
CEP350
ECgene alternative splicing isoforms for
CEP350

Expression for CEP350 Gene

mRNA expression in normal human tissues for CEP350 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP350 Gene

SOURCE GeneReport for Unigene cluster for CEP350 Gene Hs.413045

mRNA Expression by UniProt/SwissProt for CEP350 Gene

Q5VT06-CE350_HUMAN
Tissue specificity: Detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney and pancreas.
genes like me logo Genes that share expressions with CEP350: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CEP350 Gene

Orthologs for CEP350 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CEP350 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP350 35
  • 99.62 (n)
  • 99.45 (a)
CEP350 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEP350 35
  • 89.64 (n)
  • 87.13 (a)
CEP350 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP350 35
  • 90.69 (n)
  • 88.93 (a)
CEP350 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep350 35
  • 83.4 (n)
  • 80.73 (a)
Cep350 16
Cep350 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEP350 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP350 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep350 35
  • 83.16 (n)
  • 80.1 (a)
chicken
(Gallus gallus)
Aves CEP350 35
  • 68.9 (n)
  • 65.25 (a)
CEP350 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP350 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep350 35
  • 56.88 (n)
  • 51.3 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
CEP350 36
  • 44 (a)
OneToOne
si:dkey-39n1.3 35
  • 53.97 (n)
  • 48.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NIP100 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for CEP350:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP350 Gene

ENSEMBL:
Gene Tree for CEP350 (if available)
TreeFam:
Gene Tree for CEP350 (if available)

Paralogs for CEP350 Gene

Paralogs for CEP350 Gene

genes like me logo Genes that share paralogs with CEP350: view

Variants for CEP350 Gene

Sequence variations from dbSNP and Humsavar for CEP350 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs483307 -- 179,966,910(-) caaag(C/T)aaggt intron-variant
rs498625 -- 179,963,808(-) gagcc(C/T)gaata intron-variant
rs510209 -- 179,966,280(-) ggatg(C/T)ctgtt intron-variant
rs511232 -- 179,959,553(-) ggtct(C/G)aagct intron-variant
rs539324 -- 179,969,170(-) TTCCC(A/C/G)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP350 Gene

Variant ID Type Subtype PubMed ID
nsv872573 CNV Loss 21882294
nsv466228 CNV Loss 19166990
nsv520322 CNV Loss 19592680
nsv520278 CNV Gain 19592680
nsv3755 CNV Loss 18451855

Relevant External Links for CEP350 Gene

HapMap Linkage Disequilibrium report
CEP350

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP350 Gene

Disorders for CEP350 Gene

Relevant External Links for CEP350

Genetic Association Database (GAD)
CEP350
Human Genome Epidemiology (HuGE) Navigator
CEP350
genes like me logo Genes that share disorders with CEP350: view

No data available for UniProtKB/Swiss-Prot for CEP350 Gene

Publications for CEP350 Gene

  1. A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. (PMID: 16314388) Yan X. … Nigg E.A. (Mol. Biol. Cell 2006) 2 3 4 23
  2. Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex. (PMID: 17878239) Hoppeler-Lebel A. … Tassin A.-M. (J. Cell Sci. 2007) 3 4 23
  3. Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome- associated protein CAP350. (PMID: 15615782) Patel H. … Capone J.P. (J. Cell Sci. 2005) 2 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Identification of six novel genes by experimental validation of GeneMachine predicted genes. (PMID: 11891061) Makalowska I. … Carpten J.D. (Gene 2002) 3 4

Products for CEP350 Gene

Sources for CEP350 Gene

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