Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEP350 Gene

protein-coding   GIFtS: 50
GCID: GC01P179923

centrosomal protein 350kDa

 Explore 2 diseases affiliated with
CEP350 via our new
 Human Malady Compendium 
Biological research products
for CEP350
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Centrosomal Protein 350kDa1 2     Centrosome-Associated Protein 3502
CAP3501 2 3     Cep3503
KIAA04801 3     Centrosome-Associated Protein Of 350 KDa3
GM1332     

External Ids:    HGNC: 242381   Entrez Gene: 98572   Ensembl: ENSG000001358377   UniProtKB: Q5VT063   

Export aliases for CEP350 gene to outside databases

Previous GC identifers: GC01P178190 GC01P151155


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CEP350:
The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins.
The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major
microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal
protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class
of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but
their full-length nature has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CE350_HUMAN, Q5VT06
Function: Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6
and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network.
Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity

Gene Wiki entry for CEP350


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEP350 gene promoter:
         STAT1   POU3F1   STAT1beta   Roaz   STAT1alpha   SRY   POU2F1   POU2F1a   TGIF   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEP350 promoter sequence
   Search SABiosciences Chromatin IP Primers for CEP350

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP350


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.2   Ensembl cytogenetic band:  1q25.2   HGNC cytogenetic band: 1q25.2

CEP350 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP350 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P179923:  view genomic region     (about GC identifiers)

Start:
179,923,873 bp from pter      End:
180,084,015 bp from pter
Size:
160,143 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CE350_HUMAN, Q5VT06 (See protein sequence)
Recommended Name: Centrosome-associated protein 350  
Size: 3117 amino acids; 350930 Da
Subunit: Part of a ternary complex composed of SASS6, CENPJ and CEP350. Part of a ternary complex that contains CEP350,
FGFR1OP and MAPRE1. Interacts directly with FGFR1OP via its C-terminus. Interacts with NR1H3, PPARA, PPARD and PPARG.
Interacts directly with microtubules. Interacts with the fusion protein FGFR1OP-FGFR1, and by doing so recruits and
activates PI3K and PLC-gamma
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Nucleus. Note=Associated
with mitotic spindles. Nuclear, in discrete foci. Associated with intermediate filaments. Also present in the
pericentrosomal area
1 PDB 3D structure from and Proteopedia for CEP350:
2COZ (3D)    
Secondary accessions: O75068 Q8TDK3 Q8WY20

Explore the universe of human proteins at neXtProt for CEP350: NX_Q5VT06

Post-translational modifications:

  • Phosphorylated during mitosis1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5VT06

  • CEP350 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055625.4  
    ENSEMBL proteins: 
     ENSP00000356579   ENSP00000435808   ENSP00000350016   ENSP00000407044   ENSP00000432910  
     ENSP00000412460   ENSP00000409395   ENSP00000401608  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for CEP350 
    GenScript Custom Purified and Recombinant Proteins Services for CEP350
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CEP350

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005819spindle IEA--


    CEP350 for ontologies           About GeneDecksing



    CEP350 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CEP350 
    GenScript Custom Superior Antibodies Services for CEP350
    Novus Biologicals CEP350 Antibodies
    Search for Antibodies for CEP350 at Abcam  
    Uscn Antibodies for CEP350
    Search ThermoFisher Antibodies for CEP350

    Assay Products for CEP350: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CEP350
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CEP350


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CEP350 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000938 CAP-Gly_domain

    Graphical View of Domain Structure for InterPro Entry Q5VT06

    ProtoNet protein and cluster: Q5VT06

    1 Blocks protein family: IPB000938 CAP-Gly domain

    UniProtKB/Swiss-Prot: CE350_HUMAN, Q5VT06
    Similarity: Contains 1 CAP-Gly domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CE350_HUMAN, Q5VT06
    Function: Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6
    and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network.
    Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: CEP350
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEP350
    8/148 QIAGEN miScript miRNA Assays for microRNAs that regulate CEP350 (see all 148):
    hsa-miR-26a-2* hsa-miR-520f hsa-miR-3916 hsa-miR-298 hsa-miR-1243 hsa-miR-3116 hsa-miR-3170 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCEP350 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEP350
    OriGene shRNA RFP: CEP350
    OriGene siRNA: CEP350
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEP350

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CEP350

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP350 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP350
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CEP350 (NM_014810)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEP350
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP350 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CEP350
    Search LifeMap BioReagents cell lines for CEP350

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP350


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEP350

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for CEP350 (Q5VT062, 3 ENSP000003565794) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APTXQ7Z2E32, 3, ENSP000004008064MINT-2867693 I2D: score=3 STRING: ENSP00000400806
    PPP2R1AP301533, ENSP000003248044I2D: score=1 STRING: ENSP00000324804
    FGFR1OPO956843, ENSP000003558124I2D: score=1 STRING: ENSP00000355812
    PPP2CAP677753, ENSP000004184474I2D: score=1 STRING: ENSP00000418447
    PLEKHA5Q9HAU03, ENSP000002992754I2D: score=3 STRING: ENSP00000299275
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEP350
    Search CenterWatch for drugs/clinical trials and news about CEP350 / CE350 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CEP350 gene: 
    NM_014810.4  

    Unigene Cluster for CEP350:

    Centrosomal protein 350kDa
    Hs.413045  [show with all ESTs]
    Unigene Representative Sequence: NM_014810
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367607(uc001gnr.1 uc001gnu.3 uc009wxl.2 uc001gnt.3 uc001gnv.3)
    ENST00000491495 ENST00000357434 ENST00000418229 ENST00000490047 ENST00000429851(uc001gnx.1)
    ENST00000437245 ENST00000484356 ENST00000490141(uc001gnw.1) ENST00000417046
    ENST00000496440

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: CEP350
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEP350
    8/148 QIAGEN miScript miRNA Assays for microRNAs that regulate CEP350 (see all 148):
    hsa-miR-26a-2* hsa-miR-520f hsa-miR-3916 hsa-miR-298 hsa-miR-1243 hsa-miR-3116 hsa-miR-3170 hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCEP350 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEP350
    OriGene shRNA RFP: CEP350
    OriGene siRNA: CEP350
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEP350
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP350 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP350
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CEP350 (NM_014810)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEP350
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP350 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP350
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CEP350
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP350
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP350

    Additional cDNA sequence: 

    AF287356.1 AF387614.1 AK000704.1 AK022813.1 AK026986.1 AK095601.1 AK126046.1 AY007149.1 
    BC017847.1 BC033619.1 BC048310.1 

    16 DOTS entries:

    DT.97800064  DT.95272385  DT.86851491  DT.100785420  DT.97846592  DT.97763283  DT.101970237  DT.121417667 
    DT.95086619  DT.100785417  DT.114455  DT.86859778  DT.91641603  DT.97846595  DT.121417692  DT.95272384 

    24/291 AceView cDNA sequences (see all 291):

    AW135157 AI609558 AI018580 AA278795 BC048310 AI799277 AI620345 AA576746 
    AW517039 AI222122 BX280772 AI015864 BU176159 AA281306 AA536104 BQ574614 
    CA414893 NM_014810 CB133971 AY007149 AU133409 AK126046 BF438913 AA281257 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CEP350 (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                                                                                                                                                            
    SP2:                                                              -     -     -     -     -     -     -     -     -                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:              -                 -     -                                                                                                                     

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b ^ 34a · 34b · 34c · 34d ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^
    SP1:                                                              -                                   -     -     -     -     -                             -   
    SP2:                                                              -                                                                                             
    SP3:                                                                                                  -     -     -     -     -                             -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 41 ^ 42 ^ 43 ^ 44 ^ 45
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for CEP350

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEP350 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TATACCTGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CEP350 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CEP350

    SOURCE GeneReport for Unigene cluster: Hs.413045

    UniProtKB/Swiss-Prot: CE350_HUMAN, Q5VT06
    Tissue specificity: Detected in heart, brain, skeletal muscle, testis, placenta, lung, liver, kidney and pancreas

        SABiosciences Custom PCR Arrays for CEP350
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP350
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CEP350
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP350
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP350
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP350

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CEP350 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cep3501 , 5 centrosomal protein 3501, 5 83.66(n)1
    81.05(a)1
      1 (67.64 cM)5
    740811  NM_001039184.11  NP_001034273.11 
     1558449665 
    chicken
    (Gallus gallus)
    Aves CEP3501 centrosomal protein 350kDa 68.95(n)
    65.46(a)
      424417  XM_422260.3  XP_422260.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    CEP3506
    (see all 3)
    --
    59(a)
    56(a)
    (see all 3)
    many → 1
    many → 1
    (see all 3)
    4(70536232-70583732)
    4(70591887-70606702)
    zebrafish
    (Danio rerio)
    Actinopterygii BM860114.12   -- 74.32(n)   335035  BM860114.1 


    ENSEMBL Gene Tree for CEP350 (if available)
    TreeFam Gene Tree for CEP350 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CEP350 gene
    CLIP22  CLIP32  TBCB2  CLIP42  CLIP12  DCTN12  ENSG000002643242  
    7 SIMAP similar genes for CEP350 using alignment to 10 protein entries:     CE350_HUMAN (see all proteins):
    KIAA0480    FAM138D    FAM138A    FAM138B    FAM138C    FAM138F
    DCTN1

    CEP350 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2612 NCBI SNPs in CEP350 are shown (see all 2612    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs357218761,2
    C,--151279993(+) TATAG-/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1897307831,2
    --179922051(+) CTAGTA/TCAAAA 1 -- us2k10--------
    rs1831638421,2
    --179922375(+) TAGCTG/TTTTCA 1 -- us2k10--------
    rs2007727401,2
    --179922409(+) CTTTC-/TTTTTT 1 -- us2k10--------
    rs1880450311,2
    --179922472(+) GGTGCA/GATCCC 1 -- us2k10--------
    rs1401866051,2
    --179922495(+) CCTCCA/GCCTCG 1 -- us2k10--------
    rs1917767891,2
    --179922534(+) CTCCCG/TAGTAG 1 -- us2k10--------
    rs1835651871,2
    --179922589(+) TTTTTA/GGTAGA 1 -- us2k10--------
    rs1116338791,2
    F,--179922641(+) TGACCC/TCGTGA 1 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1149497591,2
    F,--179922715(+) ACGTGT/GTTCTT 1 -- us2k11Minor allele frequency- G:0.02WA 118

    HapMap Linkage Disequilibrium report for CEP350 (179923873 - 180084015 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CEP350
         2 CNVs: 84687 48185
         1 Indel: 74799

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP350
    DNA2.0 Custom Variant and Variant Library Synthesis for CEP350

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CEP350 for disorders           About GeneDecksing

    2 diseases for CEP350:    About MalaCards
    myeloproliferative disorder    ataxia

    Human Genome Epidemiology (HuGE) Navigator: CEP350 (1 document)

    Export disorders for CEP350 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEP350 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with CEP350)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A complex of two centrosomal proteins, CAP350 and FOP, cooperates with EB1 in microtubule anchoring. (PubMed id 16314388)1, 2, 3, 9 Yan X.... Nigg E.A. (2006)
    2. Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome- associated protein CAP350. (PubMed id 15615782)1, 2, 3 Patel H.... Capone J.P. (2005)
    3. Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex. (PubMed id 17878239)1, 2, 9 Hoppeler-Lebel A.... Tassin A.-M. (2007)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843)1, 2 Andersen J.S....Mann M. (2003)
    7. Identification of six novel genes by experimental validation of GeneMachine predicted genes. (PubMed id 11891061)1, 2 Makalowska I.... Carpten J.D. (2002)
    8. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    9. The Arabidopsis TRM1-TON1 interaction reveals a recrui tment network common to plant cortical microtubule arrays and eukaryotic centros omes. (PubMed id 22286137)1 Drevensek S....Pastuglia M. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9857 HGNC: 24238 AceView: CAP350 Ensembl:ENSG00000135837 euGenes: HUgn9857
    ECgene: CEP350 H-InvDB: CEP350

    (According to HUGE)
    About This Section
    HUGE: KIAA0480

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEP350 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CEP350 gene:
    Search GeneIP for patents involving CEP350

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CEP350  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEP350   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEP350  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CEP350   OriGene 3'-UTR Clone for CEP350  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEP350   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEP350  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CEP350   OriGene Custom Protein Services for CEP350  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CEP350
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP350
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP350
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEP350
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP350
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP350
     GenScript Custom Purified and Recombinant Proteins Services for CEP350 GenScript cDNA clones with any tag delivered in your preferred vector for CEP350
     GenScript Custom Assay Services for CEP350 GenScript Custom Superior Antibodies Services for CEP350
     GenScript Custom overexpressing Cell Line Services for CEP350 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CEP350 promoter
     Search Chromatin IP Primers for CEP350
     RT2 qPCR Primer Assay in human, mouse, rat CEP350
     Search GNC Networks for CEP350
     SABiosciences Custom PCR Arrays for CEP350
     Search Tocris compounds for CEP350
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CEP350 antibodies
     Search for Antibodies for CEP350 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CEP350
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CEP350 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CEP350
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP350
     SwitchGear 3'UTR luciferase reporter plasmids for CEP350
     SwitchGear Promoter luciferase reporter plasmids for CEP350
     Search ThermoFisher Antibodies for CEP350
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP350
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CEP350 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4