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Aliases for CEP295 Gene

Aliases for CEP295 Gene

  • Centrosomal Protein 295kDa 2 3
  • KIAA1731 2 3 4
  • Centrosomal Protein Of 295 KDa 3
  • Centriolar Protein CEP295 3

External Ids for CEP295 Gene

Previous Symbols for CEP295 Gene

  • KIAA1731

Summaries for CEP295 Gene

GeneCards Summary for CEP295 Gene

CEP295 (Centrosomal Protein 295kDa) is a Protein Coding gene. An important paralog of this gene is CEP295NL.

UniProtKB/Swiss-Prot for CEP295 Gene

  • Centriole-enriched protein that mediates centriole-to-centrosome conversion at late mitosis, but is dispensable for cartwheel removal or centriole disengagement.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP295 Gene

Genomics for CEP295 Gene

Genomic Location for CEP295 Gene

Start:
93,661,639 bp from pter
End:
93,730,358 bp from pter
Size:
68,720 bases
Orientation:
Plus strand

Genomic View for CEP295 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP295 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP295 Gene

No data available for Regulatory Elements for CEP295 Gene

Proteins for CEP295 Gene

  • Protein details for CEP295 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0D2-CE295_HUMAN
    Recommended name:
    Centrosomal protein of 295 kDa
    Protein Accession:
    Q9C0D2
    Secondary Accessions:
    • C9J5H9
    • C9JQY8
    • Q8N7L4
    • Q8N919
    • Q8N9B0
    • Q96LT8

    Protein attributes for CEP295 Gene

    Size:
    2601 amino acids
    Molecular mass:
    295176 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB21822.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB21822.2; Type=Frameshift; Positions=2016; Evidence={ECO:0000305}; Sequence=BAB71582.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC04638.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP295 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP295 Gene

Proteomics data for CEP295 Gene at MOPED

Post-translational modifications for CEP295 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CEP295 Gene

No data available for DME Specific Peptides for CEP295 Gene

Domains for CEP295 Gene

Protein Domains for CEP295 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with CEP295: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CEP295 Gene

Function for CEP295 Gene

Molecular function for CEP295 Gene

UniProtKB/Swiss-Prot Function: Centriole-enriched protein that mediates centriole-to-centrosome conversion at late mitosis, but is dispensable for cartwheel removal or centriole disengagement.

miRNA for CEP295 Gene

miRTarBase miRNAs that target CEP295

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEP295 Gene

Localization for CEP295 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP295 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Associates with both of the converted centrioles during G1 but becomes more enriched at the newly formed daughter (or unconverted) centrioles during S, G2, and early M phases. Colocalizes with SASS6 and CEP250 proteins (PubMed:25131205). Colocalizes with centriolar acetylated tubulin (PubMed:20844083). {ECO:0000269 PubMed:20844083, ECO:0000269 PubMed:25131205}.

Gene Ontology (GO) - Cellular Components for CEP295 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20844083
GO:0005813 centrosome IDA 20844083
GO:0005814 centriole IDA 25131205
GO:0005856 cytoskeleton IDA 20844083
genes like me logo Genes that share ontologies with CEP295: view

Pathways for CEP295 Gene

SuperPathways for CEP295 Gene

No Data Available

Interacting Proteins for CEP295 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000316681%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000326514%0d%0a9606.ENSP00000372035%0d%0a
Selected Interacting proteins: ENSP00000316681 Q9C0D2-CE295_HUMAN for CEP295 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CEP295 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1902117 positive regulation of organelle assembly IDA 25131205
genes like me logo Genes that share ontologies with CEP295: view

No data available for Pathways by source for CEP295 Gene

Transcripts for CEP295 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CEP295 Gene

No ASD Table

Relevant External Links for CEP295 Gene

GeneLoc Exon Structure for
CEP295
ECgene alternative splicing isoforms for
CEP295

Expression for CEP295 Gene

mRNA expression in normal human tissues for CEP295 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CEP295 Gene

genes like me logo Genes that share expressions with CEP295: view

Orthologs for CEP295 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP295 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1731 36
  • 99.27 (n)
  • 98.46 (a)
KIAA1731 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1731 36
  • 82.2 (n)
  • 71.38 (a)
KIAA1731 37
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1731 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 5830418K08Rik 36
  • 74.34 (n)
  • 62.5 (a)
5830418K08Rik 16
5830418K08Rik 37
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA1731 37
  • 20 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1731 37
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1311723 36
  • 74.12 (n)
  • 61.56 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 43 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii KIAA1731 37
  • 43 (a)
OneToMany
Species with no ortholog for CEP295:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP295 Gene

ENSEMBL:
Gene Tree for CEP295 (if available)
TreeFam:
Gene Tree for CEP295 (if available)

Paralogs for CEP295 Gene

Paralogs for CEP295 Gene

genes like me logo Genes that share paralogs with CEP295: view

Variants for CEP295 Gene

Sequence variations from dbSNP and Humsavar for CEP295 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs10360 -- 93,729,948(-) GCCTT(A/G)GAGCC missense, reference
rs542032 -- 93,692,664(-) tgggc(A/C)acata intron-variant
rs542055 -- 93,692,656(-) atagc(A/C)agacg intron-variant
rs586655 -- 93,724,992(-) caggc(A/G)tgagc intron-variant
rs603360 -- 93,723,589(-) GAACT(C/G)TATGA intron-variant

Relevant External Links for CEP295 Gene

HapMap Linkage Disequilibrium report
CEP295

No data available for Structural Variations from Database of Genomic Variants (DGV) for CEP295 Gene

Disorders for CEP295 Gene

No disorders were found for CEP295 Gene.

No data available for UniProtKB/Swiss-Prot for CEP295 Gene

Publications for CEP295 Gene

  1. Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731. (PMID: 20844083) Knorz V.J. … Hearn T. (Mol. Biol. Cell 2010) 2 3 4
  2. Stabilization of cartwheel-less centrioles for duplication requires CEP295-mediated centriole-to-centrosome conversion. (PMID: 25131205) Izquierdo D. … Tsou M.F. (Cell Rep. 2014) 2 3 4
  3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. (PMID: 17043677) Camargo L.M. … Brandon N.J. (Mol. Psychiatry 2007) 3

Products for CEP295 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CEP295
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CEP295
    • Block miRNA regulation of CEP295 using miScript Target Protectors

    Sources for CEP295 Gene

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