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Aliases for CEP192 Gene

Aliases for CEP192 Gene

  • Centrosomal Protein 192 2 3
  • Centrosomal Protein 192kDa 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 62 3
  • 192 KDa Centrosomal Protein 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 62 2
  • KIAA1569 4
  • PPP1R62 3
  • Cep192 4

External Ids for CEP192 Gene

Previous GeneCards Identifiers for CEP192 Gene

  • GC18U900257

Summaries for CEP192 Gene

GeneCards Summary for CEP192 Gene

CEP192 (Centrosomal Protein 192) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include phosphatase binding.

UniProtKB/Swiss-Prot for CEP192 Gene

  • Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication.

Gene Wiki entry for CEP192 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP192 Gene

Genomics for CEP192 Gene

Regulatory Elements for CEP192 Gene

Enhancers for CEP192 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CEP192 on UCSC Golden Path with GeneCards custom track

Promoters for CEP192 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEP192 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEP192 Gene

Chromosome:
18
Start:
12,991,321 bp from pter
End:
13,125,053 bp from pter
Size:
133,733 bases
Orientation:
Plus strand

Genomic View for CEP192 Gene

Genes around CEP192 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP192 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP192 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP192 Gene

Proteins for CEP192 Gene

  • Protein details for CEP192 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEP8-CE192_HUMAN
    Recommended name:
    Centrosomal protein of 192 kDa
    Protein Accession:
    Q8TEP8
    Secondary Accessions:
    • A0A060A9S4
    • E9PF99
    • Q8WYT8
    • Q9H0F4
    • Q9NW27

    Protein attributes for CEP192 Gene

    Size:
    1941 amino acids
    Molecular mass:
    213146 Da
    Quaternary structure:
    • Interacts with SHBG.
    SequenceCaution:
    • Sequence=AAL55870.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91559.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66752.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66752.1; Type=Frameshift; Positions=1196, 1239; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEP192 Gene

    Alternative splice isoforms for CEP192 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP192 Gene

Proteomics data for CEP192 Gene at MOPED

Post-translational modifications for CEP192 Gene

  • Hydroxylation by PHD1/EGLN2 at Pro-1717 promotes ubiquitination.
  • Ubiquitinated by a SCF(SKP2) complex following proline hydroxylation.
  • Ubiquitination at Lys 1379 and Lys 1482
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP192 Gene

Domains & Families for CEP192 Gene

Gene Families for CEP192 Gene

Protein Domains for CEP192 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP192 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEP192: view

No data available for UniProtKB/Swiss-Prot for CEP192 Gene

Function for CEP192 Gene

Molecular function for CEP192 Gene

UniProtKB/Swiss-Prot Function:
Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication.
genes like me logo Genes that share phenotypes with CEP192: view

Animal Model Products

miRNA for CEP192 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP192 Gene

Localization for CEP192 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP192 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Pericentriolar location in mitotic centrosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP192 Gene COMPARTMENTS Subcellular localization image for CEP192 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for CEP192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IEA --
genes like me logo Genes that share ontologies with CEP192: view

Pathways & Interactions for CEP192 Gene

genes like me logo Genes that share pathways with CEP192: view

Pathways by source for CEP192 Gene

Gene Ontology (GO) - Biological Process for CEP192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0051225 spindle assembly IEA,IMP 17980596
genes like me logo Genes that share ontologies with CEP192: view

No data available for SIGNOR curated interactions for CEP192 Gene

Drugs & Compounds for CEP192 Gene

No Compound Related Data Available

Transcripts for CEP192 Gene

mRNA/cDNA for CEP192 Gene

(14) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEP192 Gene

Centrosomal protein 192kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP192 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
SP1: -
SP2: -
SP3: - - - - - -
SP4:
SP5: - - - - - -
SP6:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5:
SP6: - -

Relevant External Links for CEP192 Gene

GeneLoc Exon Structure for
CEP192
ECgene alternative splicing isoforms for
CEP192

Expression for CEP192 Gene

mRNA expression in normal human tissues for CEP192 Gene

Protein differential expression in normal tissues from HIPED for CEP192 Gene

This gene is overexpressed in Platelet (13.5), CD8 Tcells (12.4), Peripheral blood mononuclear cells (11.3), Adipocyte (10.7), and Blymphocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP192 Gene



SOURCE GeneReport for Unigene cluster for CEP192 Gene Hs.100914

genes like me logo Genes that share expression patterns with CEP192: view

Protein tissue co-expression partners for CEP192 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP192 Gene

Orthologs for CEP192 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP192 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CEP192 35
  • 83.33 (n)
  • 76.54 (a)
mouse
(Mus musculus)
Mammalia Cep192 35
  • 76.63 (n)
  • 66.47 (a)
Cep192 16
Cep192 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CEP192 35
  • 99.44 (n)
  • 98.94 (a)
CEP192 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEP192 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEP192 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves CEP192 35
  • 60.19 (n)
  • 50.24 (a)
CEP192 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP192 36
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep192 35
  • 57.01 (n)
  • 48.22 (a)
zebrafish
(Danio rerio)
Actinopterygii CEP192 36
  • 39 (a)
OneToOne
Species with no ortholog for CEP192:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP192 Gene

ENSEMBL:
Gene Tree for CEP192 (if available)
TreeFam:
Gene Tree for CEP192 (if available)

Paralogs for CEP192 Gene

genes like me logo Genes that share paralogs with CEP192: view

No data available for Paralogs for CEP192 Gene

Variants for CEP192 Gene

Sequence variations from dbSNP and Humsavar for CEP192 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10048340 - 13,053,058(+) CTACC(A/C/G)CAGCC nc-transcript-variant, reference, missense
rs2282542 - 13,056,683(+) CAGGA(A/G)TGACA nc-transcript-variant, reference, missense
rs11080623 - 13,055,916(+) TATCC(A/C)GAATA nc-transcript-variant, reference, missense
rs7228940 - 13,068,110(+) CTGGC(A/G)CTGTT nc-transcript-variant, reference, missense
rs578208 - 13,068,133(+) AGGAA(C/T)CCGTC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CEP192 Gene

Variant ID Type Subtype PubMed ID
nsv437176 CNV Loss 16327808
nsv833591 CNV Gain 17160897
esv2716816 CNV Deletion 23290073
esv2716817 CNV Deletion 23290073
esv2716819 CNV Deletion 23290073
esv3139 CNV Deletion 18987735
nsv515878 CNV Loss 19592680
dgv3388n71 CNV Loss 21882294

Variation tolerance for CEP192 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.29; 96.28% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CEP192 Gene

Disorders for CEP192 Gene

Relevant External Links for CEP192

Genetic Association Database (GAD)
CEP192
Human Genome Epidemiology (HuGE) Navigator
CEP192
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP192

No disorders were found for CEP192 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP192 Gene

Publications for CEP192 Gene

  1. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen J.S. … Mann M. (Nature 2003) 2 3 4 67
  2. Human Cep192 is required for mitotic centrosome and spindle assembly. (PMID: 17980596) Gomez-Ferreria M.A. … Sharp D.J. (Curr. Biol. 2007) 3 23
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3
  4. Bimodal Interaction of Mammalian Polo-Like Kinase 1 and a Centrosomal Scaffold, Cep192, in the Regulation of Bipolar Spindle Formation. (PMID: 26012549) Meng L. … Lee K.S. (Mol. Cell. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CEP192 Gene

Sources for CEP192 Gene

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