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Aliases for CEP192 Gene

Aliases for CEP192 Gene

  • Centrosomal Protein 192kDa 2 3
  • Protein Phosphatase 1, Regulatory Subunit 62 3
  • Centrosomal Protein Of 192 KDa 3
  • 192 KDa Centrosomal Protein 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 62 2
  • KIAA1569 4
  • PPP1R62 3
  • Cep192 4

External Ids for CEP192 Gene

Summaries for CEP192 Gene

GeneCards Summary for CEP192 Gene

CEP192 (Centrosomal Protein 192kDa) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include phosphatase binding.

UniProtKB/Swiss-Prot for CEP192 Gene

  • Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication.

Gene Wiki entry for CEP192 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP192 Gene

Genomics for CEP192 Gene

Genomic Location for CEP192 Gene

Start:
12,991,353 bp from pter
End:
13,125,053 bp from pter
Size:
133,701 bases
Orientation:
Plus strand

Genomic View for CEP192 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP192 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP192 Gene

Regulatory Elements for CEP192 Gene

Proteins for CEP192 Gene

  • Protein details for CEP192 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEP8-CE192_HUMAN
    Recommended name:
    Centrosomal protein of 192 kDa
    Protein Accession:
    Q8TEP8
    Secondary Accessions:
    • A0A060A9S4
    • E9PF99
    • Q8WYT8
    • Q9H0F4
    • Q9NW27

    Protein attributes for CEP192 Gene

    Size:
    1941 amino acids
    Molecular mass:
    213146 Da
    Quaternary structure:
    • Interacts with SHBG.
    SequenceCaution:
    • Sequence=AAL55870.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91559.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66752.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66752.1; Type=Frameshift; Positions=1196, 1239; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP192 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP192 Gene

Proteomics data for CEP192 Gene at MOPED

Post-translational modifications for CEP192 Gene

  • Hydroxylation by PHD1/EGLN2 at Pro-1717 promotes ubiquitination.
  • Ubiquitinated by a SCF(SKP2) complex following proline hydroxylation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys1379 and Lys1482

No data available for DME Specific Peptides for CEP192 Gene

Domains for CEP192 Gene

Gene Families for CEP192 Gene

HGNC:
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for CEP192 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with CEP192: view

No data available for UniProtKB/Swiss-Prot for CEP192 Gene

Function for CEP192 Gene

Molecular function for CEP192 Gene

UniProtKB/Swiss-Prot Function: Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication.

Gene Ontology (GO) - Molecular Function for CEP192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19389623
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with CEP192: view
genes like me logo Genes that share phenotypes with CEP192: view

miRNA for CEP192 Gene

miRTarBase miRNAs that target CEP192

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEP192 Gene

Localization for CEP192 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP192 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Pericentriolar location in mitotic centrosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP192 Gene COMPARTMENTS Subcellular localization image for CEP192 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for CEP192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IEA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005814 centriole IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CEP192: view

Pathways for CEP192 Gene

genes like me logo Genes that share pathways with CEP192: view

Pathways by source for CEP192 Gene

Gene Ontology (GO) - Biological Process for CEP192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0051225 spindle assembly IMP 17980596
genes like me logo Genes that share ontologies with CEP192: view

Transcripts for CEP192 Gene

mRNA/cDNA for CEP192 Gene

(14) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEP192 Gene

Centrosomal protein 192kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP192 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
SP1: -
SP2: -
SP3: - - - - - -
SP4:
SP5: - - - - - -
SP6:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5:
SP6: - -

Relevant External Links for CEP192 Gene

GeneLoc Exon Structure for
CEP192
ECgene alternative splicing isoforms for
CEP192

Expression for CEP192 Gene

mRNA expression in normal human tissues for CEP192 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP192 Gene

SOURCE GeneReport for Unigene cluster for CEP192 Gene Hs.100914

genes like me logo Genes that share expressions with CEP192: view

Orthologs for CEP192 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP192 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP192 36
  • 99.44 (n)
  • 98.94 (a)
CEP192 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEP192 37
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEP192 36
  • 83.33 (n)
  • 76.54 (a)
mouse
(Mus musculus)
Mammalia Cep192 36
  • 76.63 (n)
  • 66.47 (a)
Cep192 16
Cep192 37
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEP192 37
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 71 (a)
OneToMany
-- 37
  • 54 (a)
OneToMany
-- 37
  • 68 (a)
OneToMany
-- 37
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves CEP192 36
  • 60.19 (n)
  • 50.24 (a)
CEP192 37
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP192 37
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep192 36
  • 57.01 (n)
  • 48.22 (a)
zebrafish
(Danio rerio)
Actinopterygii CEP192 37
  • 39 (a)
OneToOne
Species with no ortholog for CEP192:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP192 Gene

ENSEMBL:
Gene Tree for CEP192 (if available)
TreeFam:
Gene Tree for CEP192 (if available)

Paralogs for CEP192 Gene

genes like me logo Genes that share paralogs with CEP192: view

No data available for Paralogs for CEP192 Gene

Variants for CEP192 Gene

Sequence variations from dbSNP and Humsavar for CEP192 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs14891 -- 13,124,878(-) TTATA(G/T)ATATC utr-variant-3-prime, downstream-variant-500B
rs472394 -- 13,110,066(-) GCAGG(C/G)CAGGG intron-variant
rs472702 -- 13,058,495(+) GTCCT(C/T)AGGTT intron-variant, downstream-variant-500B
rs472992 -- 13,087,790(-) CATCA(C/T)CCACA intron-variant
rs473580 -- 13,059,495(+) TACAG(A/T)AACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP192 Gene

Variant ID Type Subtype PubMed ID
nsv437176 CNV Loss 16327808
nsv833591 CNV Gain 17160897
esv2716816 CNV Deletion 23290073
esv2716817 CNV Deletion 23290073
esv2716819 CNV Deletion 23290073
esv3139 CNV Deletion 18987735
nsv515878 CNV Loss 19592680
dgv3388n71 CNV Loss 21882294

Relevant External Links for CEP192 Gene

HapMap Linkage Disequilibrium report
CEP192

Disorders for CEP192 Gene

Relevant External Links for CEP192

Genetic Association Database (GAD)
CEP192
Human Genome Epidemiology (HuGE) Navigator
CEP192
genes like me logo Genes that share disorders with CEP192: view

No data available for UniProtKB/Swiss-Prot for CEP192 Gene

Publications for CEP192 Gene

  1. Human Cep192 is required for mitotic centrosome and spindle assembly. (PMID: 17980596) Gomez-Ferreria M.A. … Sharp D.J. (Curr. Biol. 2007) 3 4 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen J.S. … Mann M. (Nature 2003) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. (PMID: 15862967) Pope S.N. … Lee I.R. (J. Steroid Biochem. Mol. Biol. 2005) 3 4

Products for CEP192 Gene

Sources for CEP192 Gene

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