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Aliases for CEP192 Gene

Aliases for CEP192 Gene

  • Centrosomal Protein 192 2 3 5
  • Protein Phosphatase 1, Regulatory Subunit 62 2 3
  • Centrosomal Protein 192kDa 2 3
  • Centrosomal Protein Of 192 KDa 3
  • 192 KDa Centrosomal Protein 3
  • KIAA1569 4
  • PPP1R62 3
  • Cep192 4

External Ids for CEP192 Gene

Previous GeneCards Identifiers for CEP192 Gene

  • GC18U900257

Summaries for CEP192 Gene

GeneCards Summary for CEP192 Gene

CEP192 (Centrosomal Protein 192) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include phosphatase binding.

UniProtKB/Swiss-Prot for CEP192 Gene

  • Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication.

Gene Wiki entry for CEP192 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP192 Gene

Genomics for CEP192 Gene

Regulatory Elements for CEP192 Gene

Enhancers for CEP192 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F013113 1 ENCODE 75.5 +121.9 121866 0.2 CTCF SAP130 FOXA3 HLF ARID4B REST MNT RAD21 TEAD3 SMC3 CEP192 GC18P013115 PIR52762
GH18F013135 0.9 Ensembl ENCODE 69.4 +146.2 146164 3.5 PKNOX1 ARID4B DMAP1 ZNF48 YY1 PAF1 NFYC TBX21 KAT8 NFIL3 CEP192 GC18P013134 LOC646203
GH18F012989 0.2 ENCODE 67.6 -0.2 -167 3.7 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 CEP192 PRELID3A ENSG00000267199 ENSG00000266969 HMGB3P28 SEH1L GC18P012986
GH18F012946 0.8 ENCODE 60.9 -43.6 -43614 3.3 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 CEP192 SEH1L GC18M014171
GH18F012944 0.4 ENCODE 42.4 -46.4 -46424 1.0 OSR2 ZNF341 KDM1A PRDM10 YY1 CEP192 CEP76 PSMG2 SEH1L PTPN2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CEP192 on UCSC Golden Path with GeneCards custom track

Promoters for CEP192 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000522711 379 2601 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2

Genomic Location for CEP192 Gene

Chromosome:
18
Start:
12,991,321 bp from pter
End:
13,125,053 bp from pter
Size:
133,733 bases
Orientation:
Plus strand

Genomic View for CEP192 Gene

Genes around CEP192 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP192 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP192 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP192 Gene

Proteins for CEP192 Gene

  • Protein details for CEP192 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEP8-CE192_HUMAN
    Recommended name:
    Centrosomal protein of 192 kDa
    Protein Accession:
    Q8TEP8
    Secondary Accessions:
    • A0A060A9S4
    • B7ZMF0
    • E9PF99
    • Q8WYT8
    • Q9H0F4
    • Q9NW27

    Protein attributes for CEP192 Gene

    Size:
    1941 amino acids
    Molecular mass:
    213146 Da
    Quaternary structure:
    • Interacts with SHBG.
    SequenceCaution:
    • Sequence=AAL55870.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91559.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66752.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB66752.1; Type=Frameshift; Positions=1196, 1239; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEP192 Gene

    Alternative splice isoforms for CEP192 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP192 Gene

Post-translational modifications for CEP192 Gene

  • Hydroxylation by PHD1/EGLN2 at Pro-1717 promotes ubiquitination.
  • Ubiquitinated by a SCF(SKP2) complex following proline hydroxylation.
  • Ubiquitination at Lys 1379 and Lys 1482
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP192 Gene

Domains & Families for CEP192 Gene

Gene Families for CEP192 Gene

Protein Domains for CEP192 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP192 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEP192: view

No data available for UniProtKB/Swiss-Prot for CEP192 Gene

Function for CEP192 Gene

Molecular function for CEP192 Gene

UniProtKB/Swiss-Prot Function:
Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication.

Gene Ontology (GO) - Molecular Function for CEP192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19389623
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with CEP192: view
genes like me logo Genes that share phenotypes with CEP192: view

Animal Model Products

miRNA for CEP192 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP192 Gene

Localization for CEP192 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP192 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Pericentriolar location in mitotic centrosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEP192 Gene COMPARTMENTS Subcellular localization image for CEP192 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for CEP192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IEA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IEA,IDA 17980596
GO:0005814 centriole IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CEP192: view

Pathways & Interactions for CEP192 Gene

genes like me logo Genes that share pathways with CEP192: view

Pathways by source for CEP192 Gene

Gene Ontology (GO) - Biological Process for CEP192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0051225 spindle assembly IEA,IMP 17980596
GO:0051298 centrosome duplication IEA,IMP 17980596
genes like me logo Genes that share ontologies with CEP192: view

No data available for SIGNOR curated interactions for CEP192 Gene

Transcripts for CEP192 Gene

mRNA/cDNA for CEP192 Gene

(15) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEP192 Gene

Centrosomal protein 192kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP192 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^
SP1: -
SP2: -
SP3: - - - - - -
SP4:
SP5: - - - - - -
SP6:

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5:
SP6: - -

Relevant External Links for CEP192 Gene

GeneLoc Exon Structure for
CEP192
ECgene alternative splicing isoforms for
CEP192

Expression for CEP192 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEP192 Gene

Protein differential expression in normal tissues from HIPED for CEP192 Gene

This gene is overexpressed in Platelet (13.5), CD8 Tcells (12.4), Peripheral blood mononuclear cells (11.3), Adipocyte (10.7), and Blymphocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEP192 Gene



Protein tissue co-expression partners for CEP192 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CEP192 Gene:

CEP192

SOURCE GeneReport for Unigene cluster for CEP192 Gene:

Hs.100914
genes like me logo Genes that share expression patterns with CEP192: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP192 Gene

Orthologs for CEP192 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP192 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP192 34 35
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia CEP192 34
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Cep192 34 16 35
  • 76.63 (n)
cow
(Bos Taurus)
Mammalia CEP192 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
-- 35
  • 68 (a)
OneToMany
-- 35
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CEP192 35
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP192 34 35
  • 60.19 (n)
lizard
(Anolis carolinensis)
Reptilia CEP192 35
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep192 34
  • 57.01 (n)
zebrafish
(Danio rerio)
Actinopterygii CEP192 35
  • 39 (a)
OneToOne
Species where no ortholog for CEP192 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP192 Gene

ENSEMBL:
Gene Tree for CEP192 (if available)
TreeFam:
Gene Tree for CEP192 (if available)

Paralogs for CEP192 Gene

No data available for Paralogs for CEP192 Gene

Variants for CEP192 Gene

Sequence variations from dbSNP and Humsavar for CEP192 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs10048340 -- 13,053,058(+) CTACC(A/C/G)CAGCC nc-transcript-variant, reference, missense
rs10221326 -- 13,036,035(+) CAGCT(G/T)TTGGG intron-variant
rs10221384 -- 13,035,832(+) GTTCT(A/G)TGCTG intron-variant
rs10545331 -- 13,118,296(+) AAGTC(-/TCTC)ATTTT intron-variant
rs10586819 -- 13,009,015(+) TTTTT(-/TT)GCTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP192 Gene

Variant ID Type Subtype PubMed ID
esv2716816 CNV deletion 23290073
esv2716817 CNV deletion 23290073
esv2716819 CNV deletion 23290073
esv3139 CNV loss 18987735
esv3555072 CNV deletion 23714750
esv3582980 CNV loss 25503493
esv3641849 CNV loss 21293372
nsv1057083 CNV gain 25217958
nsv1113907 CNV deletion 24896259
nsv437176 CNV loss 16327808
nsv515878 CNV loss 19592680
nsv576524 CNV gain 21841781
nsv833591 CNV gain 17160897
nsv960255 CNV duplication 23825009

Variation tolerance for CEP192 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.29; 96.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP192 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP192

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP192 Gene

Disorders for CEP192 Gene

Relevant External Links for CEP192

Genetic Association Database (GAD)
CEP192
Human Genome Epidemiology (HuGE) Navigator
CEP192
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP192

No disorders were found for CEP192 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP192 Gene

Publications for CEP192 Gene

  1. Human Cep192 is required for mitotic centrosome and spindle assembly. (PMID: 17980596) Gomez-Ferreria M.A. … Sharp D.J. (Curr. Biol. 2007) 3 4 22 64
  2. Proteomic characterization of the human centrosome by protein correlation profiling. (PMID: 14654843) Andersen J.S. … Mann M. (Nature 2003) 2 3 4 64
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  4. PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192. (PMID: 23932902) Moser S.C. … Rocha S. (Dev. Cell 2013) 3 4 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for CEP192 Gene

Sources for CEP192 Gene

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