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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEP19 Gene

protein-coding   GIFtS: 37
GCID: GC03M196434

Centrosomal Protein 19kDa

(Previous name: chromosome 3 open reading frame 34)
(Previous symbol: C3orf34)
  Search for CEP19
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Centrosomal Protein 19kDa1 2
C3orf341 2 3
Chromosome 3 Open Reading Frame 341
Centrosomal Protein Of 19 KDa2

External Ids:    HGNC: 282091   Entrez Gene: 849842   Ensembl: ENSG000001740077   UniProtKB: Q96LK03   

Export aliases for CEP19 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CEP19 Gene: 
CEP19 (centrosomal protein 19kDa) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_029928.13  NC_018914.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CEP19
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CEP19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

CEP19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP19 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M196434:  view genomic region     (about GC identifiers)

Start:
196,433,148 bp from pter      End:
196,439,164 bp from pter
Size:
6,017 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CEP19_HUMAN, Q96LK0 (See protein sequence)
Recommended Name: Centrosomal protein of 19 kDa  
Size: 163 amino acids; 19166 Da
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm,
cytoskeleton, spindle pole. Note=Associates with the mother centriole in early interphase. Localizes to spindle
poles during mitosis, and to distinct foci oriented towards the midbody at telophase
Sequence caution: Sequence=AAM47487.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB71691.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RA74 Q96I48

Explore the universe of human proteins at neXtProt for CEP19: NX_Q96LK0

Explore proteomics data for CEP19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96LK0

  • CEP19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CEP19 Protein Expression
    REFSEQ proteins: NP_116287.2  
    ENSEMBL proteins: 
     ENSP00000387209   ENSP00000382823  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA--
    GO:0005814centriole IDA--

    CEP19 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96LK0

    UniProtKB/Swiss-Prot: CEP19_HUMAN, Q96LK0
    Similarity: Belongs to the CEP19 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CEP19 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CEP19 
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    SwitchGear 3'UTR luciferase reporter plasmidCEP19 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEP19

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for CEP19 (Q96LK02, 3 ENSP000003872094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KXD1Q9BQD32, 3, ENSP000002223074MINT-66218 I2D: score=4 STRING: ENSP00000222307
    RABL2BQ9UNT13, ENSP000003789584I2D: score=4 STRING: ENSP00000378958
    CREB3L2ENSP000003291404STRING: ENSP00000329140
    --Q8WUI72MINT-66843
    --ENSP000002944194STRING: ENSP00000294419
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEP19

    Search CenterWatch for drugs/clinical trials and news about CEP19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CEP19 gene: 
    NM_032898.3  

    Unigene Cluster for CEP19:

    Centrosomal protein 19kDa
    Hs.282800  [show with all ESTs]
    Unigene Representative Sequence: NM_032898
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409690(uc011btw.2) ENST00000399942
    miRNA
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    hsa-miR-548j hsa-miR-548i hsa-miR-578 hsa-miR-29b-1* hsa-miR-570 hsa-miR-3167 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidCEP19 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AK058155.1 AK314070.1 AY099509.1 BC007827.2 

    4 DOTS entries:

    DT.95365552  DT.305524  DT.40291470  DT.100743455 

    16 AceView cDNA sequences:

    BX281054 NM_032898 BE618769 AA329841 CB129719 BX459623 AA248667 BP370129 
    AY099509 AK058155 CD251407 BC007827 BE618233 BF795387 BE267478 BM050432 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEP19 expression in normal human tissues (normalized intensities)      CEP19 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGGATCTG
    CEP19 Expression
    About this image


    CEP19 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See CEP19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CEP19

    SOURCE GeneReport for Unigene cluster: Hs.282800
        SABiosciences Custom PCR Arrays for CEP19
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CEP19 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cep191 , 5 RIKEN cDNA 1500031L02 gene5
    centrosomal protein 191
    83.44(n)1
    85.28(a)1
      16 (22.40 cM)5
    669941  NM_025892.21  NP_080168.11 
     320998005 
    chicken
    (Gallus gallus)
    Aves CEP191 centrosomal protein 19kDa 74.38(n)
    76.87(a)
      424858  XM_001232788.2  XP_001232789.1 
    lizard
    (Anolis carolinensis)
    Reptilia CEP196
    Uncharacterized protein
    72(a)
    1 ↔ 1
    3(30799381-30802689)
    zebrafish
    (Danio rerio)
    Actinopterygii cep191 centrosomal protein 19 54.93(n)
    52.2(a)
      619252  NM_001033734.1  NP_001028906.1 


    ENSEMBL Gene Tree for CEP19 (if available)
    TreeFam Gene Tree for CEP19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CEP19 gene

    CEP19 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CEP19
    PGOHUM00000240565


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/137 SNPs in CEP19 are shown (see all 137)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1401621271,2
    C--196432715(+) GCCCAC/GGAGTT 1 -- ds50010--------
    rs713237401,2
    C,F--196432911(+) AGAGTG/AAGACC 1 -- ds50012Minor allele frequency- A:0.50NA 4
    rs1846550391,2
    --196432977(+) ACTATA/GTAGAT 1 -- ds50010--------
    rs1498500391,2
    C--196432990(+) GGAAAG/TATCTC 1 -- ds50010--------
    rs801345261,2
    C,F--196432999(+) TCTAAT/CTCAGA 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs98496841,2
    C,F,A,H--196433031(+) CTACTG/ATATGT 1 -- ds500121Minor allele frequency- A:0.24EA NS NA CSA WA 2123
    rs1892026421,2
    --196433051(+) GACTAC/TTTCAA 1 -- ds50010--------
    rs772418941,2
    C,F--196433109(+) CTTAAT/CGGTAA 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1809343771,2
    --196433239(+) ATAAAG/TGTATC 1 -- ut310--------
    rs1458912781,2
    --196433244(+) TGTATC/TAAATC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CEP19 (196433148 - 196439164 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CEP19:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829828CNV Loss17160897
    nsv878189CNV Loss21882294
    dgv5375n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEP19 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CEP19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PubMed id 21399614)1, 2, 3 Jakobsen L.... Andersen J.S. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    6. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84984 HGNC: 28209 AceView: MGC14126 Ensembl:ENSG00000174007 euGenes: HUgn84984
    ECgene: CEP19 H-InvDB: CEP19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEP19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CEP19 gene:
    Search GeneIP for patents involving CEP19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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