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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEP19 Gene

protein-coding   GIFtS: 39
GCID: GC03M196434

centrosomal protein 19kDa

(Previous name: chromosome 3 open reading frame 34 )
(Previous symbol: C3orf34)
  Search for CEP19
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CEP19    

Aliases
for CEP19 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Centrosomal Protein 19kDa1 2
C3orf341 2 3
MGC141261
Chromosome 3 Open Reading Frame 341
Centrosomal Protein Of 19 KDa2

External Ids:    HGNC: 282091   Entrez Gene: 849842   Ensembl: ENSG000001740077   UniProtKB: Q96LK03   

Export aliases for CEP19 gene to outside databases


Summaries
for CEP19 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for CEP19 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_029928.13  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CEP19
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CEP19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q29   Ensembl cytogenetic band:  3q29   HGNC cytogenetic band: 3q29

CEP19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP19 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M196434:  view genomic region     (about GC identifiers)

Start:
 196,433,148 bp from pter      End:
 196,439,164 bp from pter
Size:
 6,017 bases      Orientation:
 minus strand

Proteins
for CEP19 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CEP19_HUMAN, Q96LK0 (See protein sequence)
Recommended Name: Centrosomal protein of 19 kDa  
Size: 163 amino acids; 19166 Da
Subcellular location: Cytoplasm, cytoskeleton, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole.
Note=Associates with the mother centriole in early interphase. Localizes to spindle poles during mitosis, and to
distinct foci oriented towards the midbody at telophase
Sequence caution: Sequence=AAM47487.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB71691.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2RA74 Q96I48

Explore the universe of human proteins at neXtProt for CEP19: NX_Q96LK0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96LK0

    • CEP19 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_116287.2  
    ENSEMBL proteins: 
     ENSP00000387209   ENSP00000382823  

    Human Recombinant Protein Products: 
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    Uscn Proteins for CEP19

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA--
    GO:0005814centriole IDA--


    CEP19 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CEP19

    Protein Domains /
    Families
    for CEP19 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96LK0

    UniProtKB/Swiss-Prot: CEP19_HUMAN, Q96LK0
    Similarity: Belongs to the CEP19 family


    Function
    for CEP19 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEP19
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate CEP19 (see all 20):
    hsa-miR-548j hsa-miR-548i hsa-miR-578 hsa-miR-29b-1* hsa-miR-570 hsa-miR-3167 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CEP19 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Pathways & Interactions
    for CEP19 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEP19

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for CEP19 (Q96LK02, 3 ENSP000003872094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KXD1Q9BQD32, 3, ENSP000002223074MINT-66218 I2D: score=4 STRING: ENSP00000222307
    RABL2BQ9UNT13, ENSP000003789584I2D: score=4 STRING: ENSP00000378958
    CREB3L2ENSP000003291404STRING: ENSP00000329140
    --Q8WUI72MINT-66843
    --ENSP000002944194STRING: ENSP00000294419
    About this table

    Drugs & Compounds
    for CEP19 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEP19
    Search CenterWatch for drugs/clinical trials and news about CEP19 

    Transcripts
    for CEP19 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CEP19 gene: 
    NM_032898.3  

    Unigene Cluster for CEP19:

    Centrosomal protein 19kDa
    Hs.282800  [show with all ESTs]
    Unigene Representative Sequence: NM_032898
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409690(uc011btw.2) ENST00000399942

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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate CEP19 (see all 20):
    hsa-miR-548j hsa-miR-548i hsa-miR-578 hsa-miR-29b-1* hsa-miR-570 hsa-miR-3167 hsa-miR-548d-5p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: CEP19 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEP19 (see all 4)
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEP19
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    Additional cDNA sequence: 

    AK058155.1 AK314070.1 AY099509.1 BC007827.2 

    4 DOTS entries:

    DT.95365552  DT.305524  DT.40291470  DT.100743455 

    16 AceView cDNA sequences:

    BX281054 BP370129 BE618769 AA329841 AA248667 BX459623 AY099509 CD251407 
    BE618233 CB129719 NM_032898 BC007827 AK058155 BM050432 BE267478 BF795387 

    GeneLoc Exon Structure


    Expression
    for CEP19 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEP19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATGGATCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CEP19 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CEP19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CEP19

    SOURCE GeneReport for Unigene cluster: Hs.282800
        SABiosciences Custom PCR Arrays for CEP19
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP19

    Orthologs
    for CEP19 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CEP19 gene from 4/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cep191 , 5 RIKEN cDNA 1500031L02 gene5
    centrosomal protein 191    		 83.44(n)1
    85.28(a)1    		   16 (22.40 cM)5
    669941  NM_025892.21  NP_080168.11 
     320998005 
    chicken
    (Gallus gallus)    		 Aves CEP191 centrosomal protein 19kDa 74.38(n)
    76.87(a)    		   424858  XM_001232788.2  XP_001232789.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CEP196
    		 --
    		 72(a)
    		 1 ↔ 1
    		 3(30799406-30802640)
    zebrafish
    (Danio rerio)    		 Actinopterygii cep191 centrosomal protein 19 54.93(n)
    52.2(a)    		   619252  NM_001033734.1  NP_001028906.1 


    ENSEMBL Gene Tree for CEP19 (if available)
    TreeFam Gene Tree for CEP19 (if available) 

    Paralogs
    for CEP19 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CEP19 gene

    CEP19 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CEP19
    PGOHUM00000240565


    Genomic Variants
    for CEP19 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/116 NCBI SNPs in CEP19 are shown (see all 116)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1401621271,2
    		--196432715(+) GCCCAC/GGAGTT 1 -- ds50010--------
    rs713237401,2
    		C,F,--196432911(+) AGAGTG/AAGACC 1 -- ds50012Minor allele frequency- A:0.50NA 4
    rs1846550391,2
    		--196432977(+) ACTATA/GTAGAT 1 -- ds50010--------
    rs1498500391,2
    		C,--196432990(+) GGAAAG/TATCTC 1 -- ds50010--------
    rs801345261,2
    		C,F,--196432999(+) TCTAAT/CTCAGA 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs98496841,2
    		C,F,A,H,--196433031(+) CTACTG/ATATGT 1 -- ds500121Minor allele frequency- A:0.24EA NS NA CSA WA 2123
    rs1892026421,2
    		--196433051(+) GACTAC/TTTCAA 1 -- ds50010--------
    rs772418941,2
    		F,--196433109(+) CTTAAT/CGGTAA 1 -- ds50011Minor allele frequency- C:0.02WA 118
    rs1809343771,2
    		--196433239(+) ATAAAG/TGTATC 1 -- ut310--------
    rs1458912781,2
    		--196433244(+) TGTATC/TAAATC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CEP19 (196433148 - 196439164 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CEP19: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP19
    DNA2.0 Custom Variant and Variant Library Synthesis for CEP19

    Disorders / Diseases
    for CEP19 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for CEP19 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEP19 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CEP19)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PubMed id 21399614)1, 2, 3 Jakobsen L.... Andersen J.S. (2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    6. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for CEP19 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CEP19 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84984 HGNC: 28209 AceView: MGC14126 Ensembl:ENSG00000174007 euGenes: HUgn84984
    ECgene: CEP19 H-InvDB: CEP19

    Other Databases showing CEP19 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CEP19 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEP19 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CEP19 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CEP19 gene:
    Search GeneIP for patents involving CEP19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CEP19 gene

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    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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