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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEP170P1 Gene

pseudogene   GIFtS: 33
GCID: GC04P119389

Centrosomal Protein 170kDa Pseudogene 1

(Previous names: KIAA0470-like, centrosomal protein 170kDa-like)
(Previous symbols: KIAA0470L, CEP170L)
  Search for CEP170P1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Centrosomal Protein 170kDa Pseudogene 11 2     Centrosomal Protein 170kDa-Like1
CEP170L1 2 3     FAM68B2
KIAA0470L1 2 3     CEP170 Pseudogene 13
KIAA0470-like1     

External Ids:    HGNC: 283641   Entrez Gene: 6454552   Ensembl: ENSG000001546087   UniProtKB: Q96L143   

Export aliases for CEP170P1 gene to outside databases

Previous GC identifer: GC04P119438


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CEP170P1 Gene:
This locus appears to be a transcribed pseudogene similar to centrosomal protein 170kDa (CEP170). An approximately
50 kb region upstream of this locus also is homologous to CEP170, but is not transcribed. (provided by RefSeq,
Jul 2008)

GeneCards Summary for CEP170P1 Gene: 
CEP170P1 (centrosomal protein 170kDa pseudogene 1) is a pseudogene. GO annotations related to this gene include identical protein binding.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CEP170P1
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP170P1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

CEP170P1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP170P1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P119389:  view genomic region     (about GC identifiers)

Start:
119,388,745 bp from pter      End:
119,476,483 bp from pter
Size:
87,739 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: C170L_HUMAN, Q96L14 (See protein sequence)
Recommended Name: Cep170-like protein  
Size: 293 amino acids; 32648 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for CEP170P1: NX_Q96L14

Explore proteomics data for CEP170P1 at MOPED 

CEP170P1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CEP170P1 Protein Expression

Human Recombinant Protein Products for CEP170P1: 

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q96L14

UniProtKB/Swiss-Prot: C170L_HUMAN, Q96L14
Similarity: Belongs to the CEP170 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0042802identical protein binding IPI16189514
     
CEP170P1 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEP170P1

5/21 Interacting proteins for CEP170P1 (Q96L141, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
InteractantInteraction Details
GeneCardExternal ID(s)
ABI3Q9P2A42, 3MINT-67986 I2D: score=2 
AIMP2Q131552, 3MINT-66734 I2D: score=2 
C1orf216Q8TAB52, 3MINT-67177 I2D: score=2 
CENPOQ9BU642, 3MINT-66747 I2D: score=2 
KXD1Q9BQD32, 3MINT-67950 I2D: score=2 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CEP170P1 (C170L)

Search CenterWatch for drugs/clinical trials and news about CEP170P1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CEP170P1 gene: 
NM_153243.2  

Unigene Cluster for CEP170P1:

Centrosomal protein 170kDa pseudogene 1
Hs.408293  [show with all ESTs]
Unigene Representative Sequence: BC014590
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000502249(uc010imy.1) ENST00000412784(uc003icb.3) ENST00000450306

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Additional mRNA sequence: 

BC014590.2 NR_003135.2 

10 DOTS entries:

DT.95272851  DT.95249724  DT.100817540  DT.121361886  DT.100713982  DT.102829563  DT.121361586  DT.121361776 
DT.40125270  DT.121275089 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CEP170P1    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c
SP1:                                      -     -                                                   
SP2:        -                             -     -                                                   
SP3:                                                                                                
SP4:                                            -                                                   
SP5:                                            -                                                   


ECgene alternative splicing isoforms for CEP170P1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CEP170P1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGATTTCCCA
CEP170P1 Expression
About this image


See CEP170P1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEP170P1

SOURCE GeneReport for Unigene cluster: Hs.408293
    SABiosciences Custom PCR Arrays for CEP170P1
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP170P1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP170P1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for CEP170P1 (if available)
TreeFam Gene Tree for CEP170P1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CEP170P1 gene
3 SIMAP similar genes for CEP170P1 using alignment to 1 protein entry:     C170L_HUMAN:
DKFZp564B0982    CEP170    CEP170B

CEP170P1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/720 SNPs in CEP170P1 are shown (see all 720)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2002739091,2
C--119435614(+) GTTAT-/AAAGAG 1 -- us2k10--------
rs2014069951,2
F--119435699(+) GAAAGT/ACAACC 1 -- us2k11Minor allele frequency- A:0.05EU 571
rs2021029411,2
C--119435862(+) TGGTCG/ATAAAT 1 -- us2k11Minor allele frequency- A:0.00EU 578
rs2013674221,2
F--119435997(+) TAAACC/TTCATG 1 -- us2k11Minor allele frequency- T:0.13EU 580
rs725510181,2
C,F--119436130(+) AGGCCG/ACGACC 1 -- us2k13Minor allele frequency- A:0.45NA EU 579
rs2019420711,2
F--119436263(+) CCACAG/AGAAGG 1 -- us2k11Minor allele frequency- A:0.01EU 575
rs27281821,2
C,F,O,H--119436487(+) AAGGTC/TAAAAG 1 -- us2k1 ese32Minor allele frequency- T:0.23EA NS 178
rs2020134291,2
C--119436576(+) TTTTT-/TGAAAA 1 -- us2k10--------
rs27281841,2
C--119436589(+) TTTTTA/G/TAAAAA 1 -- us2k1 trp31WA 2
rs2012888231,2
--119436589(+) TTTTT-/GAAAAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CEP170P1 (119388745 - 119476483 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for CEP170P1:    About this table     
Variant IDTypeSubtypePubMed ID
nsv519017CNV Loss19592680
nsv830044CNV Loss17160897
esv34038CNV Loss18971310
esv34354CNV Gain17911159
dgv1668e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CEP170P1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CEP170P1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Shifted Transversal Design smart-pooling for high cov erage interactome mapping. (PubMed id 19447967)1 Xin X....Thierry-Mieg N. (2009)
  2. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 645455 HGNC: 28364 Ensembl:ENSG00000154608 euGenes: HUgn645455 ECgene: CEP170P1
H-InvDB: CEP170P1

(According to HUGE)
About This Section
HUGE: KIAA0470L KIAA0470-like

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CEP170P1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CEP170P1 gene:
Search GeneIP for patents involving CEP170P1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for CEP170P1
 Gene Synthesis
 Protein Engineering
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 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP170P1
 Browse SwitchGear 3'UTR luciferase reporter plasmids for CEP170P1
 Browse SwitchGear Promoter luciferase reporter plasmids for CEP170P1
 Search ThermoFisher Antibodies for CEP170P1
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CEP170P1
 inGenious Targeting Laboratory - Custom generated mouse model solutions for CEP170P1
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CEP170P1
Customized:
 lentivirus for stable overexpression of CEP170P1
 lentivirus expression plasmids for stable overexpression of CEP170P1
 adenovirus for overexpression of CEP170P1
 Search LSBio for Antibodies for CEP170P1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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