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Aliases for CEP170B Gene

Aliases for CEP170B Gene

  • Centrosomal Protein 170B 2 3 4
  • KIAA0284 2 3 4
  • Cep170-Related 2 3
  • FAM68C 3 4
  • Centrosomal Protein Of 170 KDa Protein B 3
  • CEP170R 3
  • Cep170B 4

External Ids for CEP170B Gene

Previous HGNC Symbols for CEP170B Gene

  • KIAA0284

Previous GeneCards Identifiers for CEP170B Gene

  • GC14P105332

Summaries for CEP170B Gene

GeneCards Summary for CEP170B Gene

CEP170B (Centrosomal Protein 170B) is a Protein Coding gene. An important paralog of this gene is CEP170.

UniProtKB/Swiss-Prot for CEP170B Gene

  • Plays a role in microtubule organization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP170B Gene

Genomics for CEP170B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CEP170B Gene

Start:
104,865,280 bp from pter
End:
104,896,770 bp from pter
Size:
31,491 bases
Orientation:
Plus strand

Genomic View for CEP170B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP170B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP170B Gene

No data available for Regulatory Elements for CEP170B Gene

Proteins for CEP170B Gene

  • Protein details for CEP170B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4F5-C170B_HUMAN
    Recommended name:
    Centrosomal protein of 170 kDa protein B
    Protein Accession:
    Q9Y4F5
    Secondary Accessions:
    • Q2KHR7
    • Q86TI7

    Protein attributes for CEP170B Gene

    Size:
    1589 amino acids
    Molecular mass:
    171688 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47913.1; Type=Frameshift; Positions=1379; Evidence={ECO:0000305}; Sequence=BAA22953.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP170B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP170B Gene

Proteomics data for CEP170B Gene at MOPED

Post-translational modifications for CEP170B Gene

  • Ubiquitination at Lys289
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP170B Gene

No data available for DME Specific Peptides for CEP170B Gene

Domains for CEP170B Gene

Protein Domains for CEP170B Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y4F5

UniProtKB/Swiss-Prot:

C170B_HUMAN :
  • Q9Y4F5
Domain:
  • Contains 1 FHA domain.
Family:
  • Belongs to the CEP170 family.
genes like me logo Genes that share domains with CEP170B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CEP170B Gene

Function for CEP170B Gene

Molecular function for CEP170B Gene

UniProtKB/Swiss-Prot Function: Plays a role in microtubule organization.

Gene Ontology (GO) - Molecular Function for CEP170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CEP170B: view

Animal Model Products

CRISPR Products

miRNA for CEP170B Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEP170B Gene

Localization for CEP170B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP170B Gene

Cytoplasm, cytoskeleton.

Gene Ontology (GO) - Cellular Components for CEP170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with CEP170B: view

No data available for Subcellular locations from COMPARTMENTS for CEP170B Gene

Pathways for CEP170B Gene

SuperPathways for CEP170B Gene

No Data Available

Interacting Proteins for CEP170B Gene

Gene Ontology (GO) - Biological Process for CEP170B Gene

None

No data available for Pathways by source for CEP170B Gene

Transcripts for CEP170B Gene

Unigene Clusters for CEP170B Gene

Centrosomal protein 170B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP170B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CEP170B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP170B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for CEP170B Gene

GeneLoc Exon Structure for
CEP170B
ECgene alternative splicing isoforms for
CEP170B

Expression for CEP170B Gene

mRNA expression in normal human tissues for CEP170B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP170B Gene

SOURCE GeneReport for Unigene cluster for CEP170B Gene Hs.533721

genes like me logo Genes that share expressions with CEP170B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP170B Gene

Orthologs for CEP170B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP170B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP170B 36
  • 95 (a)
OneToOne
KIAA0284 35
  • 96.68 (n)
  • 95.42 (a)
cow
(Bos Taurus)
Mammalia CEP170B 36
  • 76 (a)
OneToOne
KIAA0284 35
  • 82.55 (n)
  • 80.66 (a)
dog
(Canis familiaris)
Mammalia CEP170B 36
  • 75 (a)
OneToOne
KIAA0284 35
  • 80.95 (n)
  • 78.31 (a)
mouse
(Mus musculus)
Mammalia Cep170b 35
  • 80.77 (n)
  • 81.68 (a)
Cep170b 16
Cep170b 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEP170B 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP170B 36
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cep170b 35
  • 80.2 (n)
  • 81.29 (a)
chicken
(Gallus gallus)
Aves CEP170B 36
  • 54 (a)
OneToOne
KIAA0284 35
  • 62.34 (n)
  • 59.97 (a)
lizard
(Anolis carolinensis)
Reptilia CEP170B 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13597 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cep170b 35
  • 54.88 (n)
  • 54.54 (a)
zebrafish
(Danio rerio)
Actinopterygii CEP170B (1 of 3) 36
  • 33 (a)
OneToMany
CEP170B (2 of 3) 36
  • 37 (a)
OneToMany
CEP170B (3 of 3) 36
  • 83 (a)
OneToMany
si:ch73-212j7.1 35
  • 53.29 (n)
  • 51.48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for CEP170B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP170B Gene

ENSEMBL:
Gene Tree for CEP170B (if available)
TreeFam:
Gene Tree for CEP170B (if available)

Paralogs for CEP170B Gene

Paralogs for CEP170B Gene

Selected SIMAP similar genes for CEP170B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CEP170B: view

Variants for CEP170B Gene

Sequence variations from dbSNP and Humsavar for CEP170B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs752265 -- 104,895,597(-) TCCAC(A/G)GGGCA utr-variant-3-prime
rs894038 -- 104,885,336(-) CGAGG(A/G)TCAGA intron-variant
rs1866824 -- 104,891,978(+) TTCTC(C/T)GGTCG intron-variant
rs1866825 -- 104,892,012(+) GGTGC(C/T)GCTGG intron-variant
rs1982230 -- 104,880,808(-) GGGTG(G/T)GCATG intron-variant

Relevant External Links for CEP170B Gene

HapMap Linkage Disequilibrium report
CEP170B
Human Gene Mutation Database (HGMD)
CEP170B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CEP170B Gene

Disorders for CEP170B Gene

No disorders were found for CEP170B Gene.

No data available for UniProtKB/Swiss-Prot for CEP170B Gene

Publications for CEP170B Gene

  1. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PMID: 9179496) Ohara O. … Nomura N. (DNA Res. 1997) 3 4
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  3. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PMID: 17370265) Denis N.J. … Figeys D. (Proteomics 2007) 3 4
  4. The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle. (PMID: 23087211) Welburn J.P. … Cheeseman I.M. (Mol. Biol. Cell 2012) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CEP170B Gene

  • antibodies-online peptides for CEP170B
  • antibodies-online antibodies for CEP170B
  • antibodies-online kits for CEP170B

Sources for CEP170B Gene

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