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Aliases for CEP170B Gene

Aliases for CEP170B Gene

  • Centrosomal Protein 170B 2 3 4 5
  • KIAA0284 2 3 4
  • Cep170-Related 2 3
  • FAM68C 3 4
  • Centrosomal Protein Of 170 KDa Protein B 3
  • CEP170R 3
  • Cep170B 4

External Ids for CEP170B Gene

Previous HGNC Symbols for CEP170B Gene

  • KIAA0284

Previous GeneCards Identifiers for CEP170B Gene

  • GC14P105332

Summaries for CEP170B Gene

GeneCards Summary for CEP170B Gene

CEP170B (Centrosomal Protein 170B) is a Protein Coding gene. An important paralog of this gene is CEP170.

UniProtKB/Swiss-Prot for CEP170B Gene

  • Plays a role in microtubule organization.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP170B Gene

Genomics for CEP170B Gene

Regulatory Elements for CEP170B Gene

Enhancers for CEP170B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G104863 1.8 FANTOM5 Ensembl ENCODE dbSUPER 14.9 +0.3 251 4.7 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF263 SP3 SP5 MXD4 KAT8 LINC00638 CEP170B C14orf79 ENSG00000257270 ENSG00000259067
GH14G104871 1.3 Ensembl ENCODE dbSUPER 14 +7.4 7405 2.1 PKNOX1 ZSCAN4 SIN3A MAX ZIC2 ZNF664 HIC1 ZNF316 ZFHX2 POLR2A CEP170B ENSG00000259067
GH14G104814 1.4 ENCODE dbSUPER 9.7 -49.5 -49483 2.8 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF610 GLIS1 LINC00638 TMEM121 ENSG00000257270 PACS2 CEP170B CRIP2 ENSG00000279140
GH14G104825 1.2 Ensembl ENCODE 10.5 -38.4 -38371 2.9 HDGF AGO1 ARID4B SIN3A ZNF48 ZBTB7B GLIS2 ZNF143 KLF7 FOS LINC00638 ADSSL1 CEP170B RPS26P49
GH14G104882 0.9 ENCODE dbSUPER 13.6 +17.2 17219 0.3 MAZ SP3 KLF1 SP2 OSR2 ZFP69B ZFHX2 GATA3 GLIS2 ZNF692 CEP170B PLD4 ENSG00000259067
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEP170B on UCSC Golden Path with GeneCards custom track

Promoters for CEP170B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000073729 20 2201 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 GLIS2 KLF7 ZNF263 SP3

Genomic Location for CEP170B Gene

Chromosome:
14
Start:
104,865,280 bp from pter
End:
104,896,770 bp from pter
Size:
31,491 bases
Orientation:
Plus strand

Genomic View for CEP170B Gene

Genes around CEP170B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP170B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP170B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP170B Gene

Proteins for CEP170B Gene

  • Protein details for CEP170B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4F5-C170B_HUMAN
    Recommended name:
    Centrosomal protein of 170 kDa protein B
    Protein Accession:
    Q9Y4F5
    Secondary Accessions:
    • Q2KHR7
    • Q86TI7

    Protein attributes for CEP170B Gene

    Size:
    1589 amino acids
    Molecular mass:
    171688 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH47913.1; Type=Frameshift; Positions=1379; Evidence={ECO:0000305}; Sequence=BAA22953.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP170B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP170B Gene

Post-translational modifications for CEP170B Gene

  • Ubiquitination at Lys289
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP170B Gene

Domains & Families for CEP170B Gene

Protein Domains for CEP170B Gene

Suggested Antigen Peptide Sequences for CEP170B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4F5

UniProtKB/Swiss-Prot:

C170B_HUMAN :
  • Belongs to the CEP170 family.
Family:
  • Belongs to the CEP170 family.
genes like me logo Genes that share domains with CEP170B: view

No data available for Gene Families for CEP170B Gene

Function for CEP170B Gene

Molecular function for CEP170B Gene

UniProtKB/Swiss-Prot Function:
Plays a role in microtubule organization.

Phenotypes for CEP170B Gene

genes like me logo Genes that share phenotypes with CEP170B: view

Animal Model Products

CRISPR Products

miRNA for CEP170B Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP170B Gene

Localization for CEP170B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP170B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP170B gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CEP170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with CEP170B: view

Pathways & Interactions for CEP170B Gene

SuperPathways for CEP170B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP170B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEP170B Gene

Transcripts for CEP170B Gene

Unigene Clusters for CEP170B Gene

Centrosomal protein 170B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP170B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: - -
SP3: -
SP4:

Relevant External Links for CEP170B Gene

GeneLoc Exon Structure for
CEP170B
ECgene alternative splicing isoforms for
CEP170B

Expression for CEP170B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEP170B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEP170B Gene

This gene is overexpressed in Lung (23.6), Brain (13.4), Frontal cortex (10.4), and Fetal Brain (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEP170B Gene



NURSA nuclear receptor signaling pathways regulating expression of CEP170B Gene:

CEP170B

SOURCE GeneReport for Unigene cluster for CEP170B Gene:

Hs.533721

Evidence on tissue expression from TISSUES for CEP170B Gene

  • Nervous system(4.4)
  • Liver(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with CEP170B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP170B Gene

Orthologs for CEP170B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP170B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA0284 34
  • 96.68 (n)
CEP170B 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0284 34
  • 82.55 (n)
CEP170B 35
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0284 34
  • 80.95 (n)
CEP170B 35
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cep170b 34 16 35
  • 80.77 (n)
rat
(Rattus norvegicus)
Mammalia Cep170b 34
  • 80.2 (n)
oppossum
(Monodelphis domestica)
Mammalia CEP170B 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEP170B 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0284 34
  • 62.34 (n)
CEP170B 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEP170B 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep170b 34
  • 54.88 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13597 34
zebrafish
(Danio rerio)
Actinopterygii CEP170B (3 of 3) 35
  • 83 (a)
OneToMany
si:ch73-212j7.1 34
  • 53.29 (n)
CEP170B (2 of 3) 35
  • 37 (a)
OneToMany
CEP170B (1 of 3) 35
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
Species where no ortholog for CEP170B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP170B Gene

ENSEMBL:
Gene Tree for CEP170B (if available)
TreeFam:
Gene Tree for CEP170B (if available)

Paralogs for CEP170B Gene

Paralogs for CEP170B Gene

(3) SIMAP similar genes for CEP170B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CEP170B: view

Variants for CEP170B Gene

Sequence variations from dbSNP and Humsavar for CEP170B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000055506 -- 104,895,241(+) CAAGG(A/G)CATTA utr-variant-3-prime
rs1000067146 -- 104,883,807(+) GACAA(-/GGTG)GGGTC intron-variant, upstream-variant-2KB
rs1000358416 -- 104,884,401(+) CCCCC(C/T)GACCC upstream-variant-2KB, reference, missense
rs1000477212 -- 104,865,338(+) CACGA(C/G)CGTGC upstream-variant-2KB, utr-variant-5-prime
rs1000534006 -- 104,869,807(+) GCCGG(C/T)GCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP170B Gene

Variant ID Type Subtype PubMed ID
dgv3964n54 CNV gain 21841781
dgv3965n54 CNV loss 21841781
dgv3966n54 CNV loss 21841781
dgv3967n54 CNV gain 21841781
dgv3968n54 CNV gain+loss 21841781
dgv3969n54 CNV loss 21841781
dgv3970n54 CNV gain 21841781
dgv3971n54 CNV loss 21841781
dgv3972n54 CNV loss 21841781
esv1296512 CNV deletion 17803354
esv21727 CNV loss 19812545
esv2673602 CNV deletion 23128226
esv2749248 CNV deletion 23290073
esv3635627 CNV gain 21293372
nsv1054574 CNV loss 25217958
nsv1069826 CNV deletion 25765185
nsv1108924 CNV deletion 24896259
nsv470677 CNV loss 18288195
nsv474570 CNV novel sequence insertion 20440878
nsv566099 CNV gain 21841781
nsv566101 CNV gain+loss 21841781
nsv566115 CNV gain 21841781
nsv566122 CNV gain+loss 21841781
nsv566133 CNV loss 21841781
nsv566135 CNV loss 21841781
nsv566137 CNV loss 21841781
nsv566138 CNV loss 21841781
nsv566139 CNV loss 21841781
nsv566140 CNV loss 21841781
nsv820719 CNV deletion 20802225
nsv827078 CNV gain 20364138
nsv827079 CNV gain 20364138
nsv84293 CNV deletion 16902084
nsv952272 CNV deletion 24416366
nsv952273 CNV deletion 24416366

Variation tolerance for CEP170B Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.00; 74.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP170B Gene

Human Gene Mutation Database (HGMD)
CEP170B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP170B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP170B Gene

Disorders for CEP170B Gene

Relevant External Links for CEP170B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP170B

No disorders were found for CEP170B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP170B Gene

Publications for CEP170B Gene

  1. The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle. (PMID: 23087211) Welburn J.P. … Cheeseman I.M. (Mol. Biol. Cell 2012) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64
  4. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PMID: 9179496) Ohara O. … Nomura N. (DNA Res. 1997) 3 4 64
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3 64

Products for CEP170B Gene

Sources for CEP170B Gene

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