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Aliases for CEP170B Gene

Aliases for CEP170B Gene

  • Centrosomal Protein 170B 2 3 4 5
  • KIAA0284 2 3 4
  • Cep170-Related 2 3
  • FAM68C 3 4
  • CEP170R 3
  • Cep170B 4

External Ids for CEP170B Gene

Previous HGNC Symbols for CEP170B Gene

  • KIAA0284

Previous GeneCards Identifiers for CEP170B Gene

  • GC14P105332

Summaries for CEP170B Gene

GeneCards Summary for CEP170B Gene

CEP170B (Centrosomal Protein 170B) is a Protein Coding gene. An important paralog of this gene is CEP170.

UniProtKB/Swiss-Prot for CEP170B Gene

  • Plays a role in microtubule organization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP170B Gene

Genomics for CEP170B Gene

Regulatory Elements for CEP170B Gene

Enhancers for CEP170B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CEP170B on UCSC Golden Path with GeneCards custom track

Promoters for CEP170B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEP170B on UCSC Golden Path with GeneCards custom track

Genomic Location for CEP170B Gene

104,865,280 bp from pter
104,896,770 bp from pter
31,491 bases
Plus strand

Genomic View for CEP170B Gene

Genes around CEP170B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP170B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP170B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP170B Gene

Proteins for CEP170B Gene

  • Protein details for CEP170B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Centrosomal protein of 170 kDa protein B
    Protein Accession:
    Secondary Accessions:
    • Q2KHR7
    • Q86TI7

    Protein attributes for CEP170B Gene

    1589 amino acids
    Molecular mass:
    171688 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH47913.1; Type=Frameshift; Positions=1379; Evidence={ECO:0000305}; Sequence=BAA22953.3; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP170B Gene


neXtProt entry for CEP170B Gene

Proteomics data for CEP170B Gene at MOPED

Post-translational modifications for CEP170B Gene

  • Ubiquitination at Lys 289
  • Modification sites at PhosphoSitePlus

Other Protein References for CEP170B Gene

No data available for DME Specific Peptides for CEP170B Gene

Domains & Families for CEP170B Gene

Protein Domains for CEP170B Gene

Suggested Antigen Peptide Sequences for CEP170B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FHA domain.
  • Belongs to the CEP170 family.
  • Contains 1 FHA domain.
  • Belongs to the CEP170 family.
genes like me logo Genes that share domains with CEP170B: view

No data available for Gene Families for CEP170B Gene

Function for CEP170B Gene

Molecular function for CEP170B Gene

UniProtKB/Swiss-Prot Function:
Plays a role in microtubule organization.

Phenotypes for CEP170B Gene

genes like me logo Genes that share phenotypes with CEP170B: view

Animal Model Products

miRNA for CEP170B Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP170B Gene

Localization for CEP170B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP170B Gene

Cytoplasm, cytoskeleton.

Gene Ontology (GO) - Cellular Components for CEP170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CEP170B: view

No data available for Subcellular locations from COMPARTMENTS for CEP170B Gene

Pathways & Interactions for CEP170B Gene

SuperPathways for CEP170B Gene

No Data Available

Interacting Proteins for CEP170B Gene

Gene Ontology (GO) - Biological Process for CEP170B Gene


No data available for Pathways by source and SIGNOR curated interactions for CEP170B Gene

Drugs & Compounds for CEP170B Gene

No Compound Related Data Available

Transcripts for CEP170B Gene

Unigene Clusters for CEP170B Gene

Centrosomal protein 170B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEP170B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: -
SP2: - -
SP3: -

Relevant External Links for CEP170B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CEP170B Gene

mRNA expression in normal human tissues for CEP170B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEP170B Gene

This gene is overexpressed in Lung (23.6), Brain (13.4), Frontal cortex (10.4), and Fetal Brain (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CEP170B Gene

SOURCE GeneReport for Unigene cluster for CEP170B Gene Hs.533721

genes like me logo Genes that share expression patterns with CEP170B: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CEP170B Gene

Orthologs for CEP170B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP170B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KIAA0284 35
  • 82.55 (n)
  • 80.66 (a)
CEP170B 36
  • 76 (a)
(Canis familiaris)
Mammalia KIAA0284 35
  • 80.95 (n)
  • 78.31 (a)
CEP170B 36
  • 75 (a)
(Mus musculus)
Mammalia Cep170b 35
  • 80.77 (n)
  • 81.68 (a)
Cep170b 16
Cep170b 36
  • 78 (a)
(Pan troglodytes)
Mammalia KIAA0284 35
  • 96.68 (n)
  • 95.42 (a)
CEP170B 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Cep170b 35
  • 80.2 (n)
  • 81.29 (a)
(Monodelphis domestica)
Mammalia CEP170B 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia CEP170B 36
  • 45 (a)
(Gallus gallus)
Aves KIAA0284 35
  • 62.34 (n)
  • 59.97 (a)
CEP170B 36
  • 54 (a)
(Anolis carolinensis)
Reptilia CEP170B 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cep170b 35
  • 54.88 (n)
  • 54.54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13597 35
(Danio rerio)
Actinopterygii si:ch73-212j7.1 35
  • 53.29 (n)
  • 51.48 (a)
CEP170B (1 of 3) 36
  • 33 (a)
CEP170B (2 of 3) 36
  • 37 (a)
CEP170B (3 of 3) 36
  • 83 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for CEP170B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP170B Gene

Gene Tree for CEP170B (if available)
Gene Tree for CEP170B (if available)

Paralogs for CEP170B Gene

Paralogs for CEP170B Gene

(3) SIMAP similar genes for CEP170B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CEP170B: view

Variants for CEP170B Gene

Sequence variations from dbSNP and Humsavar for CEP170B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2582534 -- 104,892,322(+) CAGGG(C/T)GGAGG intron-variant
rs2582535 -- 104,893,941(+) GCAGC(A/G)GTTTC intron-variant
rs2582536 -- 104,894,385(+) TGAGC(A/G)CTGGG intron-variant
rs2582545 -- 104,888,208(-) AGAGA(C/T)GGTCA intron-variant
rs2582548 -- 104,887,956(-) CTGCC(C/T)GAGCG reference, synonymous-codon

Variation tolerance for CEP170B Gene

Residual Variation Intolerance Score: 90.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.00; 74.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP170B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CEP170B Gene

Disorders for CEP170B Gene

Relevant External Links for CEP170B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CEP170B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP170B Gene

Publications for CEP170B Gene

  1. The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle. (PMID: 23087211) Welburn J.P. … Cheeseman I.M. (Mol. Biol. Cell 2012) 2 3 67
  2. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for CEP170B Gene

Sources for CEP170B Gene