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CEP170 Gene

protein-coding   GIFtS: 55
GCID: GC01M243287

Centrosomal Protein 170kDa

(Previous name: KIAA0470)
(Previous symbol: KIAA0470)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centrosomal Protein 170kDa1 2     KARP-1-Binding Protein2 3
KIAA04701 2 3 5     KARP 1 Binding Protein1
XRCC5 Binding Protein1 2     Centrosomal Protein Of 170 KDa2
FAM68A2 3     Cep1703
KAB2 3     KARP1-Binding Protein3

External Ids:    HGNC: 289201   Entrez Gene: 98592   Ensembl: ENSG000001437027   OMIM: 6130235   UniProtKB: Q5SW793   

Export aliases for CEP170 gene to outside databases

Previous GC identifers: GC01M239615 GC01M241354 GC01M213646


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CEP170 Gene:
The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major
microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal
appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes.
During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with
and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell
morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript
variants of this gene have been found, but the full-length nature of some of these variants has not been
determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CEP170 Gene:
CEP170 (centrosomal protein 170kDa) is a protein-coding gene. Diseases associated with CEP170 include microcephaly, and colon adenocarcinoma. An important paralog of this gene is CEP170B.

UniProtKB/Swiss-Prot: CE170_HUMAN, Q5SW79
Function: Plays a role in microtubule organization

Gene Wiki entry for CEP170 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_167186.2  NT_187519.1  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CEP170 gene promoter:
         AP-1   AML1a   p300   Lmo2   LCR-F1   c-Ets-1   Egr-2   POU2F1   POU2F1a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CEP170 promoter sequence
   Search Chromatin IP Primers for CEP170

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEP170


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q43   HGNC cytogenetic band: 1q44

CEP170 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP170 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M243287:  view genomic region     (about GC identifiers)

Start:
243,287,730 bp from pter      End:
243,418,708 bp from pter
Size:
130,979 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CE170_HUMAN, Q5SW79 (See protein sequence)
Recommended Name: Centrosomal protein of 170 kDa  
Size: 1584 amino acids; 175293 Da
Subunit: Interacts with PLK1
Sequence caution: Sequence=BAA32315.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CEP170:
4JON (3D)    
Secondary accessions: O75058 Q5SW77 Q5SW78 Q7LGA9 Q86W31 Q9UQ08 Q9UQ09
Alternative splicing: 3 isoforms:  Q5SW79-1   Q5SW79-2   Q5SW79-3   

Explore the universe of human proteins at neXtProt for CEP170: NX_Q5SW79

Explore proteomics data for CEP170 at MOPED

Post-translational modifications: 

  • Phosphorylated; probably by PLK11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CEP170 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035863.1  NP_001035864.1  NP_055627.2  

    ENSEMBL proteins: 
     ENSP00000355500   ENSP00000355502   ENSP00000355501   ENSP00000427842   ENSP00000338161  
     ENSP00000430142   ENSP00000394002   ENSP00000427843   ENSP00000430112   ENSP00000428996  
     ENSP00000428777   ENSP00000427944   ENSP00000428183   ENSP00000428400  

    CEP170 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
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    Novus Biologicals CEP170 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CEP170

    CEP170 Antibody Products:

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    Abcam antibodies for CEP170
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    LSBio Antibodies in human, mouse, rat for CEP170

    CEP170 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for CEP170


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR008984 SMAD_FHA_domain
     IPR000253 FHA_dom

    Graphical View of Domain Structure for InterPro Entry Q5SW79

    ProtoNet protein and cluster: Q5SW79

    1 Blocks protein domain: IPB000253 Forkhead-associated (FHA)

    UniProtKB/Swiss-Prot: CE170_HUMAN, Q5SW79
    Similarity: Belongs to the CEP170 family
    Similarity: Contains 1 FHA domain


    CEP170 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CE170_HUMAN, Q5SW79
    Function: Plays a role in microtubule organization

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    CEP170 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CEP170:
     Decreased nuclei size in G2M  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEP170
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CEP170

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CEP170
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CEP170

    miRNA
    Products:
        
    miRTarBase miRNAs that target CEP170:
    hsa-mir-125b-5p (MIRT045925), hsa-mir-34a-5p (MIRT047355)

    Block miRNA regulation of human, mouse, rat CEP170 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CEP170 (see all 25):
    hsa-miR-875-3p hsa-miR-106a hsa-miR-485-3p hsa-miR-301a hsa-miR-144 hsa-miR-93 hsa-miR-330-3p hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidCEP170 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CEP170
    Predesigned siRNA for gene silencing in human, mouse, rat CEP170

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CEP170

    Clone
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    OriGene ORF clones in mouse, rat for CEP170
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CEP170 (NM_001042405)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEP170
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP170

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CEP170
    Browse ESI BIO Cell Lines and PureStem Progenitors for CEP170 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP170


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CE170_HUMAN, Q5SW79: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm,
    cytoskeleton, spindle. Note=Associated with the mature mother centriole. Associated with spindle microtubules
    during mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--
    GO:0005814centriole IEA--
    GO:0005819spindle IEA--
    GO:0005874microtubule IEA--

    CEP170 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CEP170
    Interactions:

        Search GeneGlobe Interaction Network for CEP170

    Selected Interacting proteins for CEP170 (Q5SW791, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3MINT-3296253 MINT-3296270 I2D: score=1 
    DISC1Q9NRI53I2D: score=2 
    CEP170P1Q96L143I2D: score=1 
    CFTRP135693I2D: score=1 
    FYCO1Q9BQS83I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CEP170 (CE170)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CEP170 gene (3 alternative transcripts): 
    NM_001042404.1  NM_001042405.1  NM_014812.2  

    Unigene Cluster for CEP170:

    Centrosomal protein 170kDa
    Hs.533635  [show with all ESTs]
    Unigene Representative Sequence: NM_014812
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000366542(uc021plo.1) ENST00000366544(uc021plq.1) ENST00000366543(uc001hzv.1 uc021plp.1)
    ENST00000468254(uc001hzr.3) ENST00000481987 ENST00000336415 ENST00000466495
    ENST00000476661 ENST00000490813 ENST00000439296 ENST00000469646 ENST00000413359
    ENST00000464936 ENST00000468697 ENST00000492145 ENST00000451408 ENST00000518289
    ENST00000522895
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CEP170 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CEP170 (see all 25):
    hsa-miR-875-3p hsa-miR-106a hsa-miR-485-3p hsa-miR-301a hsa-miR-144 hsa-miR-93 hsa-miR-330-3p hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidCEP170 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CEP170
    Predesigned siRNA for gene silencing in human, mouse, rat CEP170
    Clone
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    OriGene clones in human, mouse for CEP170 (see all 17)
    OriGene ORF clones in mouse, rat for CEP170
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CEP170 (NM_001042405)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEP170
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEP170
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CEP170
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CEP170
      QuantiTect SYBR Green Assays in human, mouse, rat CEP170
      QuantiFast Probe-based Assays in human, mouse, rat CEP170

    Additional mRNA sequence: 

    AB007939.1 AB022657.1 AB022658.1 AB022659.1 AK001664.1 AK296812.1 AK299552.1 AK308309.1 
    AK310003.1 AK313722.1 AL161964.1 BC050722.1 BC078155.1 BC140794.1 BC146790.1 

    22 DOTS entries:

    DT.313068  DT.121361776  DT.100817540  DT.95272852  DT.100817539  DT.121361733  DT.121361886  DT.95249724 
    DT.206327  DT.95307465  DT.100713982  DT.100817538  DT.102829563  DT.121361519  DT.121361586  DT.91745757 
    DT.121275089  DT.121361522  DT.40125270  DT.91665817  DT.95272851  DT.95272853 

    Selected AceView cDNA sequences (see all 182):

    BM904540 AL161964 AB007939 AI991734 N54112 AW296525 AB022659 BX499771 
    F09864 N51847 H85363 AI149745 AI826581 AI657073 AI752998 BE536589 
    AW450812 AA640949 D81444 AA715476 AA373122 CB410835 BF362404 AA446561 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CEP170 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13
    SP1:              -                                         -           -     -     -                                             
    SP2:                                                        -                                                                     
    SP3:                                                                                -                                             
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for CEP170

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CEP170 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGTAGAAG
    CEP170 Expression
    About this image

    CEP170 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEP170 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533635
        Custom PCR Arrays for CEP170
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP170

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CEP170 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cep1701 , 5 centrosomal protein 1701, 5 88.17(n)1
    89.95(a)1
      1 (82.60 cM)5
    5453891  NM_001099637.21  NP_001093107.21 
     1767336535 
    chicken
    (Gallus gallus)
    Aves CEP1701 centrosomal protein 170kDa 77.86(n)
    78.48(a)
      421499  XM_004935453.1  XP_004935510.1 
    lizard
    (Anolis carolinensis)
    Reptilia CEP1706
    centrosomal protein 170kDa
    73(a)
    1 ↔ 1
    GL343285.1(195937-338812)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.159202 Transcribed sequence with moderate similarity to protein more 79.91(n)    142029631 
    zebrafish
    (Danio rerio)
    Actinopterygii cep170a1 centrosomal protein 170a 60.27(n)
    59.08(a)
      557463  XM_005156578.1  XP_005156635.1 


    ENSEMBL Gene Tree for CEP170 (if available)
    TreeFam Gene Tree for CEP170 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CEP170 gene
    CEP170B2  
    3 SIMAP similar genes for CEP170 using alignment to 15 protein entries:     CE170_HUMAN (see all proteins):
    DKFZp564B0982    CEP170P1    MLL-KIAA0284

    CEP170 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CEP170
    PGOHUM00000248212 PGOHUM00000259949 PGOHUM00000250791


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CEP170 (see all 2195)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs727576531,2
    --243291810(+) ACAATA/CACTTT 3 -- int10--------
    rs19842091,2
    F--243293588(-) GTCTTC/TAAAAT 3 -- int11Minor allele frequency- T:0.00NA 2
    rs17968481,2
    C,F,A,H--243296588(-) TTGAGT/GGTAGA 3 -- int110Minor allele frequency- G:0.09NA NS WA 986
    rs27872471,2
    --243300058(-) GCCCAC/TGCATC 3 -- int10--------
    rs17660151,2
    --243300181(+) GTTCTC/TCAGCA 3 -- int10--------
    rs1136419201,2
    C,F--243305367(+) ATGGAC/G/TCAAGA 3 -- int11CSA 2
    rs26311771,2
    C,F--243305998(-) AGGGCT/ATTTAA 3 -- int13Minor allele frequency- A:0.33NA 6
    rs16259431,2
    F--243306033(+) ACACTA/GTGTTA 3 -- int11Minor allele frequency- G:0.00CSA 1
    rs741509401,2
    C,F--243306229(+) ATTTTG/TGTCAT 3 -- int11Minor allele frequency- T:0.50WA 2
    rs741509411,2
    C--243306262(+) GCTACG/AGGTAT 3 -- int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for CEP170 (243287730 - 243418708 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CEP170:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519429CNV Gain19592680
    nsv873386CNV Gain21882294
    esv32774CNV Gain17666407
    nsv873388CNV Gain21882294
    nsv470790CNV Gain18288195
    nsv517939CNV Gain19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613023    OMIM disorders: --

    9 diseases for CEP170:    About MalaCards
    microcephaly    colon adenocarcinoma    cystic fibrosis    multiple sclerosis
    schizophrenia    pancreatic cancer    adenocarcinoma    pancreatitis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for CEP170:
    Microcephaly

    CEP170 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CEP170
    Human Genome Epidemiology (HuGE) Navigator: CEP170 (2 documents)

    Export disorders for CEP170 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CEP170 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with CEP170)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The forkhead-associated domain protein Cep170 interacts with Polo- like kinase 1 and serves as a marker for mature centrioles. (PubMed id 15616186)1, 2, 3 Guarguaglini G.... Nigg E.A. (Mol. Biol. Cell 2005)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. (PubMed id 19626040)1, 4 McCauley J.L....Haines J.L. (Genes Immun. 2009)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (DNA Res. 1997)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (J. Cell. Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9859 HGNC: 28920 AceView: KAB Ensembl:ENSG00000143702 euGenes: HUgn9859
    ECgene: CEP170 H-InvDB: CEP170

    (According to HUGE)
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    HUGE: KIAA0470

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CEP170 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CEP170 gene:
    Search GeneIP for patents involving CEP170

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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