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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEP170 Gene

protein-coding   GIFtS: 52
GCID: GC01M243287

centrosomal protein 170kDa

(Previous name: KIAA0470 )
(Previous symbol: KIAA0470)
 Explore 5 diseases affiliated with
CEP170 via our new
 Human Malady Compendium 
Biological research products
for CEP170
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Centrosomal Protein 170kDa1 2     Centrosomal Protein Of 170 KDa2
KIAA04701 2 3 5     XRCC5 Binding Protein2
FAM68A1 2 3     Cep1703
KAB1 2 3     KARP1-Binding Protein3
KARP-1-Binding Protein2 3     

External Ids:    HGNC: 289201   Entrez Gene: 98592   Ensembl: ENSG000001437027   OMIM: 6130235   UniProtKB: Q5SW793   

Export aliases for CEP170 gene to outside databases

Previous GC identifers: GC01M239615 GC01M241354 GC01M213646


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CEP170:
The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major
microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal
appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During
mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is
phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The
human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this
gene have been found, but the full-length nature of some of these variants has not been determined. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CE170_HUMAN, Q5SW79
Function: Plays a role in microtubule organization

Gene Wiki entry for CEP170


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEP170 gene promoter:
         AP-1   AML1a   p300   Lmo2   LCR-F1   c-Ets-1   Egr-2   POU2F1   POU2F1a   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CEP170 promoter sequence
   Search SABiosciences Chromatin IP Primers for CEP170

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP170


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q44   Ensembl cytogenetic band:  1q43   HGNC cytogenetic band: 1q44

CEP170 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP170 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M243287:  view genomic region     (about GC identifiers)

Start:
243,287,730 bp from pter      End:
243,418,708 bp from pter
Size:
130,979 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CE170_HUMAN, Q5SW79 (See protein sequence)
Recommended Name: Centrosomal protein of 170 kDa  
Size: 1584 amino acids; 175293 Da
Subunit: Interacts with PLK1
Subcellular location: Cytoplasm, cytoskeleton, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Note=Associated
with the mature mother centriole. Associated with spindle microtubules during mitosis
Sequence caution: Sequence=BAA32315.2; Type=Erroneous initiation;
Secondary accessions: O75058 Q5SW77 Q5SW78 Q7LGA9 Q86W31 Q9UQ08 Q9UQ09
Alternative splicing: 3 isoforms:  Q5SW79-1   Q5SW79-2   Q5SW79-3   

Explore the universe of human proteins at neXtProt for CEP170: NX_Q5SW79

Post-translational modifications:

  • Phosphorylated; probably by PLK11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5SW79

  • CEP170 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001035863.1  NP_001035864.1  NP_055627.2  

    ENSEMBL proteins: 
     ENSP00000355500   ENSP00000355502   ENSP00000355501   ENSP00000427842   ENSP00000338161  
     ENSP00000430142   ENSP00000394002   ENSP00000427843   ENSP00000430112   ENSP00000428996  
     ENSP00000428777   ENSP00000427944   ENSP00000428183   ENSP00000428400  

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    Uscn Proteins for CEP170

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA--
    GO:0005814centriole IEA--
    GO:0005819spindle IEA--
    GO:0005874microtubule IEA--


    CEP170 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CEP170 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR008984 SMAD_FHA_domain
     IPR000253 FHA_dom
     IPR026644 CEP170

    Graphical View of Domain Structure for InterPro Entry Q5SW79

    ProtoNet protein and cluster: Q5SW79

    1 Blocks protein family: IPB000253 Forkhead-associated (FHA)

    UniProtKB/Swiss-Prot: CE170_HUMAN, Q5SW79
    Similarity: Belongs to the CEP170 family
    Similarity: Contains 1 FHA domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CE170_HUMAN, Q5SW79
    Function: Plays a role in microtubule organization

    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate CEP170 (see all 25):
    hsa-miR-875-3p hsa-miR-106a hsa-miR-485-3p hsa-miR-301a hsa-miR-144 hsa-miR-93 hsa-miR-330-3p hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidCEP170 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP170

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    CEP170 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CEP170:
     Decreased nuclei size in G2M  Upregulation of Wnt/beta-caten 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEP170

    5/14 Interacting proteins for CEP170 (Q5SW791, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3MINT-3296253 MINT-3296270 I2D: score=1 
    DISC1Q9NRI53I2D: score=2 
    CEP170P1Q96L143I2D: score=1 
    CFTRP135693I2D: score=1 
    FYCO1Q9BQS83I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEP170
    Search CenterWatch for drugs/clinical trials and news about CEP170 / CE170 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CEP170 gene (3 alternative transcripts): 
    NM_001042404.1  NM_001042405.1  NM_014812.2  

    Unigene Cluster for CEP170:

    Centrosomal protein 170kDa
    Hs.533635  [show with all ESTs]
    Unigene Representative Sequence: NM_014812
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000366542(uc021plo.1) ENST00000366544(uc021plq.1) ENST00000366543(uc001hzv.1 uc021plp.1)
    ENST00000468254(uc001hzr.3) ENST00000481987 ENST00000336415 ENST00000466495
    ENST00000476661 ENST00000490813 ENST00000439296 ENST00000469646 ENST00000413359
    ENST00000464936 ENST00000468697 ENST00000492145 ENST00000451408 ENST00000518289
    ENST00000522895

    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate CEP170 (see all 25):
    hsa-miR-875-3p hsa-miR-106a hsa-miR-485-3p hsa-miR-301a hsa-miR-144 hsa-miR-93 hsa-miR-330-3p hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidCEP170 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEP170 (see all 3)
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    Additional cDNA sequence: 

    AB007939.1 AB022657.1 AB022658.1 AB022659.1 AK001664.1 AK296812.1 AK299552.1 AK308309.1 
    AK310003.1 AK313722.1 AL161964.1 BC050722.1 BC078155.1 BC140794.1 BC146790.1 

    21 DOTS entries:

    DT.313068  DT.121361776  DT.100817540  DT.95272852  DT.121361733  DT.121361886  DT.100817539  DT.95249724 
    DT.206327  DT.95307465  DT.100713982  DT.102829563  DT.121361586  DT.91745757  DT.121275089  DT.121361519 
    DT.121361522  DT.40125270  DT.91665817  DT.95272851  DT.95272853 

    24/182 AceView cDNA sequences (see all 182):

    AI657073 CB410835 AW296525 BQ962469 AI752998 AL701798 AA373122 AA910376 
    AI149745 AA446561 AI570189 N51847 AA640949 AI149749 AL161964 AI826581 
    AI890130 BF362404 H85363 N54112 AB022659 BE409201 BP349206 AI991734 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CEP170 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13
    SP1:              -                                         -           -     -     -                                             
    SP2:                                                        -                                                                     
    SP3:                                                                                -                                             
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for CEP170

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEP170 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGTAGAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CEP170 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CEP170

    SOURCE GeneReport for Unigene cluster: Hs.533635
        SABiosciences Custom PCR Arrays for CEP170
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP170

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CEP170 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CEP1701 centrosomal protein 170kDa 75.65(n)
    75.21(a)
      421499  XM_001234760.2  XP_001234761.2 
    lizard
    (Anolis carolinensis)
    Reptilia CEP1706
    --
    75(a)
    1 ↔ 1
    GL343285.1(197873-305709)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.159202 Transcribed sequence with moderate similarity to protein more 79.91(n)    142029631 
    zebrafish
    (Danio rerio)
    Actinopterygii cep170a1 centrosomal protein 170a 59.35(n)
    58.05(a)
      557463  XM_680542.5  XP_685634.5 


    ENSEMBL Gene Tree for CEP170 (if available)
    TreeFam Gene Tree for CEP170 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CEP170 gene
    CEP170B2  
    4 SIMAP similar genes for CEP170 using alignment to 15 protein entries:     CE170_HUMAN (see all proteins):
    DKFZp564B0982    CEP170P1    MLL-KIAA0284    FHAD1

    CEP170 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CEP170
    PGOHUM00000248212 PGOHUM00000259949 PGOHUM00000250791


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1819 NCBI SNPs in CEP170 are shown (see all 1819    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs9235571,2
    A--213797229(-) CGGGTA/CATGCA 1 -- us2k12Minor allele frequency- C:0.00NA 4
    rs115767471,2
    C,H--213797929(+) ACTTAG/AGGGAT 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs746796281,2
    F,--213799096(+) AGCGCC/TTGGAG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs46142431,2
    C,H--213799100(+) CCTGGA/CGCGCA 1 -- us2k15Minor allele frequency- C:0.00NS EA NA 422
    rs2003802451,2
    C--213800074(+) CTAATA/CANNNN 1 -- int10--------
    rs1452593231,2
    --243287245(+) GATACA/GCACGT 3 -- ds50010--------
    rs1849570071,2
    --243287343(+) CTTGAC/GCTTGA 3 -- ds50010--------
    rs1869036651,2
    --243287761(+) AAATGG/TAGTTG 3 -- ut310--------
    rs1921082161,2
    --243287800(+) TAAATC/GTAACA 3 -- ut310--------
    rs1842036001,2
    --243287886(+) CCAAAC/TTGTGT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for CEP170 (243287730 - 243418708 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CEP170
         1 CNV: 6814

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CEP170 for disorders           About GeneDecksing

    OMIM gene information: 613023    OMIM disorders: --

    5 diseases for CEP170:    About MalaCards
    multiple sclerosis    microcephaly    schizophrenia    pancreatic cancer
    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for CEP170:
    Microcephaly
    Human Genome Epidemiology (HuGE) Navigator: CEP170 (2 documents)

    Export disorders for CEP170 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEP170 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with CEP170)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The forkhead-associated domain protein Cep170 interacts with Polo- like kinase 1 and serves as a marker for mature centrioles. (PubMed id 15616186)1, 2, 3 Guarguaglini G.... Nigg E.A. (2005)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2 Seki N.... Ohara O. (1997)
    6. Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
    7. The microtubule-binding protein Cep170 promotes the ta rgeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle. (PubMed id 23087211)1 Welburn J.P. and Cheeseman I.M. (2012)
    8. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    9. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    10. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. (PubMed id 22261722)1 Al-Hakim A.K....Pelletier L. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9859 HGNC: 28920 AceView: KAB Ensembl:ENSG00000143702 euGenes: HUgn9859
    ECgene: CEP170 H-InvDB: CEP170

    (According to HUGE)
    About This Section
    HUGE: KIAA0470

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEP170 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CEP170 gene:
    Search GeneIP for patents involving CEP170

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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