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Aliases for CEP170 Gene

Aliases for CEP170 Gene

  • Centrosomal Protein 170kDa 2 3
  • KIAA0470 2 3 4
  • KARP-1-Binding Protein 3 4
  • XRCC5 Binding Protein 2 3
  • FAM68A 3 4
  • KAB 3 4
  • KARP 1 Binding Protein 2
  • KARP1-Binding Protein 4
  • Cep170 4

External Ids for CEP170 Gene

Previous HGNC Symbols for CEP170 Gene

  • KIAA0470

Previous GeneCards Identifiers for CEP170 Gene

  • GC01M239615
  • GC01M241354
  • GC01M243287
  • GC01M213646

Summaries for CEP170 Gene

Entrez Gene Summary for CEP170 Gene

  • The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CEP170 Gene

CEP170 (Centrosomal Protein 170kDa) is a Protein Coding gene. An important paralog of this gene is CEP170B.

UniProtKB/Swiss-Prot for CEP170 Gene

  • Plays a role in microtubule organization.

Gene Wiki entry for CEP170 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP170 Gene

Genomics for CEP170 Gene

Regulatory Elements for CEP170 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CEP170 Gene

243,124,428 bp from pter
243,255,406 bp from pter
130,979 bases
Minus strand

Genomic View for CEP170 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP170 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP170 Gene

Proteins for CEP170 Gene

  • Protein details for CEP170 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Centrosomal protein of 170 kDa
    Protein Accession:
    Secondary Accessions:
    • O75058
    • Q5SW77
    • Q5SW78
    • Q7LGA9
    • Q86W31
    • Q9UQ08
    • Q9UQ09

    Protein attributes for CEP170 Gene

    1584 amino acids
    Molecular mass:
    175293 Da
    Quaternary structure:
    • Interacts with PLK1.
    • Sequence=BAA32315.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEP170 Gene

    Alternative splice isoforms for CEP170 Gene


neXtProt entry for CEP170 Gene

Proteomics data for CEP170 Gene at MOPED

Post-translational modifications for CEP170 Gene

No data available for DME Specific Peptides for CEP170 Gene

Domains & Families for CEP170 Gene

Protein Domains for CEP170 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 FHA domain.
  • Belongs to the CEP170 family.
  • Contains 1 FHA domain.
  • Belongs to the CEP170 family.
genes like me logo Genes that share domains with CEP170: view

No data available for Gene Families for CEP170 Gene

Function for CEP170 Gene

Molecular function for CEP170 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in microtubule organization.

Gene Ontology (GO) - Molecular Function for CEP170 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
genes like me logo Genes that share ontologies with CEP170: view
genes like me logo Genes that share phenotypes with CEP170: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP170

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP170 Gene

Localization for CEP170 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP170 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Note=Associated with the mature mother centriole. Associated with spindle microtubules during mitosis.

Subcellular locations from

Jensen Localization Image for CEP170 Gene COMPARTMENTS Subcellular localization image for CEP170 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for CEP170 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005814 centriole IDA 24421332
GO:0005819 spindle IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with CEP170: view

Pathways & Interactions for CEP170 Gene

SuperPathways for CEP170 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP170 Gene


No data available for Pathways by source and SIGNOR curated interactions for CEP170 Gene

Drugs & Compounds for CEP170 Gene

No Compound Related Data Available

Transcripts for CEP170 Gene

Unigene Clusters for CEP170 Gene

Centrosomal protein 170kDa:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP170

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP170 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13
SP1: - - - - -
SP2: -
SP3: -

Relevant External Links for CEP170 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CEP170 Gene

mRNA expression in normal human tissues for CEP170 Gene

Protein differential expression in normal tissues from HIPED for CEP170 Gene

This gene is overexpressed in Brain (29.2), Fetal Brain (18.6), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEP170 Gene

SOURCE GeneReport for Unigene cluster for CEP170 Gene Hs.533635

genes like me logo Genes that share expression patterns with CEP170: view

Protein tissue co-expression partners for CEP170 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP170 Gene

Orthologs for CEP170 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP170 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CEP170 35
  • 92.89 (n)
  • 93.37 (a)
CEP170 36
  • 91 (a)
(Canis familiaris)
Mammalia CEP170 35
  • 92.2 (n)
  • 93.36 (a)
CEP170 36
  • 92 (a)
(Mus musculus)
Mammalia Cep170 35
  • 88.17 (n)
  • 89.95 (a)
Cep170 16
Cep170 36
  • 89 (a)
(Pan troglodytes)
Mammalia CEP170 35
  • 99.77 (n)
  • 99.87 (a)
CEP170 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Cep170 35
  • 86.64 (n)
  • 86.91 (a)
(Monodelphis domestica)
Mammalia CEP170 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia CEP170 36
  • 79 (a)
(Gallus gallus)
Aves CEP170 35
  • 77.86 (n)
  • 78.48 (a)
CEP170 36
  • 67 (a)
(Anolis carolinensis)
Reptilia CEP170 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC779465 35
  • 66.97 (n)
  • 64.64 (a)
Str.15920 35
(Danio rerio)
Actinopterygii cep170a 35
  • 60.27 (n)
  • 59.08 (a)
cep170a 36
  • 52 (a)
cep170b 36
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for CEP170:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP170 Gene

Gene Tree for CEP170 (if available)
Gene Tree for CEP170 (if available)

Paralogs for CEP170 Gene

Paralogs for CEP170 Gene Pseudogenes for CEP170 Gene

genes like me logo Genes that share paralogs with CEP170: view

Variants for CEP170 Gene

Sequence variations from dbSNP and Humsavar for CEP170 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4658540 -- 243,158,519(+) TGGCA(G/T)ACTAC intron-variant
rs67920320 -- 243,244,379(-) TGAGG(-/GT/TT)GTGTG intron-variant
VAR_031437 -
rs113074237 -- 243,229,426(+) GGAGG(-/AA/G)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEP170 Gene

Variant ID Type Subtype PubMed ID
nsv519429 CNV Gain 19592680
nsv470790 CNV Gain 18288195
esv32774 CNV Gain 17666407
nsv873386 CNV Gain 21882294
nsv873388 CNV Gain 21882294
nsv517939 CNV Gain 19592680

Variation tolerance for CEP170 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.13; 69.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP170 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP170 Gene

Disorders for CEP170 Gene

Relevant External Links for CEP170

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CEP170: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP170 Gene

Publications for CEP170 Gene

  1. Cep164, a novel centriole appendage protein required for primary cilium formation. (PMID: 17954613) Graser S. … Nigg E.A. (J. Cell Biol. 2007) 23 67
  2. The forkhead-associated domain protein Cep170 interacts with Polo- like kinase 1 and serves as a marker for mature centrioles. (PMID: 15616186) Guarguaglini G. … Nigg E.A. (Mol. Biol. Cell 2005) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. (PMID: 24421332) Kobayashi T. … Dynlacht B.D. (J. Cell Biol. 2014) 67

Products for CEP170 Gene

Sources for CEP170 Gene

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