Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CEP162 Gene

Aliases for CEP162 Gene

  • Centrosomal Protein 162kDa 2 3
  • KIAA1009 2 3 4
  • Protein QN1 Homolog 3 4
  • C6orf84 3 4
  • QN1 3 4
  • Chromosome 6 Open Reading Frame 84 2
  • Centrosomal Protein Of 162 KDa 3
  • Cep162 4

External Ids for CEP162 Gene

Previous HGNC Symbols for CEP162 Gene

  • C6orf84
  • KIAA1009

Previous GeneCards Identifiers for CEP162 Gene

  • GC06M084833

Summaries for CEP162 Gene

GeneCards Summary for CEP162 Gene

CEP162 (Centrosomal Protein 162kDa) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CEP162 Gene

  • Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP162 Gene

Genomics for CEP162 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CEP162 Gene

Start:
84,124,241 bp from pter
End:
84,227,667 bp from pter
Size:
103,427 bases
Orientation:
Minus strand

Genomic View for CEP162 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEP162 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP162 Gene

No data available for Regulatory Elements for CEP162 Gene

Proteins for CEP162 Gene

  • Protein details for CEP162 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TB80-CE162_HUMAN
    Recommended name:
    Centrosomal protein of 162 kDa
    Protein Accession:
    Q5TB80
    Secondary Accessions:
    • A6PVL7
    • A6PVL8
    • Q6P475
    • Q9Y2L2

    Protein attributes for CEP162 Gene

    Size:
    1403 amino acids
    Molecular mass:
    161943 Da
    Quaternary structure:
    • Interacts with alpha-tubulin (By similarity). Interacts with CEP290.
    Miscellaneous:
    • Promotes ectopic assembly of transition zone components at cilia tips when targeted outside distal ends of centrioles, generating extra-long cilia with strikingly swollen tips.
    SequenceCaution:
    • Sequence=BAA76853.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP162 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP162 Gene

Proteomics data for CEP162 Gene at MOPED

Post-translational modifications for CEP162 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CEP162 Gene

No data available for DME Specific Peptides for CEP162 Gene

Domains for CEP162 Gene

Protein Domains for CEP162 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5TB80

UniProtKB/Swiss-Prot:

CE162_HUMAN :
  • Q5TB80
Family:
  • Belongs to the CEP162 family.
genes like me logo Genes that share domains with CEP162: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CEP162 Gene

Function for CEP162 Gene

Molecular function for CEP162 Gene

UniProtKB/Swiss-Prot Function: Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules.

Gene Ontology (GO) - Molecular Function for CEP162 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23644468
genes like me logo Genes that share ontologies with CEP162: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CEP162 Gene

Localization for CEP162 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP162 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle. Nucleus. Note=Localizes to the distal end of centrioles throughout the cell cycle. During ciliogenesis, found at the cilia base. Localizes to spindle microtubules during mitosis.

Gene Ontology (GO) - Cellular Components for CEP162 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005814 centriole IDA 23644468
genes like me logo Genes that share ontologies with CEP162: view

No data available for Subcellular locations from COMPARTMENTS for CEP162 Gene

Pathways for CEP162 Gene

SuperPathways for CEP162 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP162 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0042384 cilium assembly IMP 23644468
genes like me logo Genes that share ontologies with CEP162: view

No data available for Pathways by source for CEP162 Gene

Transcripts for CEP162 Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEP162

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CEP162
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEP162 Gene

No ASD Table

Relevant External Links for CEP162 Gene

GeneLoc Exon Structure for
CEP162
ECgene alternative splicing isoforms for
CEP162

Expression for CEP162 Gene

mRNA expression in normal human tissues for CEP162 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CEP162 Gene

genes like me logo Genes that share expressions with CEP162: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEP162 Gene

Orthologs for CEP162 Gene

This gene was present in the common ancestor of animals.

Orthologs for CEP162 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1009 35
  • 98.17 (n)
  • 96.85 (a)
KIAA1009 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1009 35
  • 87.38 (n)
  • 83.3 (a)
KIAA1009 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1009 35
  • 88.88 (n)
  • 84.61 (a)
KIAA1009 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4922501C03Rik 35
  • 81.29 (n)
  • 75.95 (a)
4922501C03Rik 16
4922501C03Rik 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA1009 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1307365 35
  • 80.9 (n)
  • 75.59 (a)
chicken
(Gallus gallus)
Aves KIAA1009 35
  • 63.7 (n)
  • 51.3 (a)
KIAA1009 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1009 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497718 35
  • 62.86 (n)
  • 53.51 (a)
Str.18747 35
zebrafish
(Danio rerio)
Actinopterygii si:ch211-198c19.2 35
  • 53.96 (n)
  • 45.76 (a)
si:ch211-198c19.2 36
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42699 36
  • 18 (a)
OneToOne
Species with no ortholog for CEP162:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP162 Gene

ENSEMBL:
Gene Tree for CEP162 (if available)
TreeFam:
Gene Tree for CEP162 (if available)

Paralogs for CEP162 Gene

No data available for Paralogs for CEP162 Gene

Variants for CEP162 Gene

Sequence variations from dbSNP and Humsavar for CEP162 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3141 -- 84,125,069(+) TTTCT(A/G)TTAAT utr-variant-3-prime
rs728721 -- 84,138,125(-) CCATT(A/G)GTGAA intron-variant
rs768426 -- 84,195,218(+) CTACC(A/C)GCATG intron-variant
rs768427 -- 84,195,129(+) GAGAA(C/T)GATAA intron-variant
rs942388 -- 84,176,054(+) AACAG(C/T)ACCTA intron-variant

Relevant External Links for CEP162 Gene

HapMap Linkage Disequilibrium report
CEP162

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CEP162 Gene

Disorders for CEP162 Gene

No disorders were found for CEP162 Gene.

No data available for UniProtKB/Swiss-Prot for CEP162 Gene

Publications for CEP162 Gene

  1. CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base. (PMID: 23644468) Wang W.J. … Bryan Tsou M.F. (Nat. Cell Biol. 2013) 2 3 4
  2. QN1/KIAA1009: a new essential protein for chromosome segregation and mitotic spindle assembly. (PMID: 16302001) Leon A. … Crisanti P. (Oncogene 2006) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  4. Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor. (PMID: 11521196) Munnia A. … Meese E. (Oncogene 2001) 3 4
  5. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PMID: 17370265) Denis N.J. … Figeys D. (Proteomics 2007) 3 4

Products for CEP162 Gene

Sources for CEP162 Gene

Back to Top

Content