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Aliases for CEP128 Gene

Aliases for CEP128 Gene

  • Centrosomal Protein 128 2 3 5
  • Centrosomal Protein 128kDa 2 3
  • C14orf145 3 4
  • C14orf61 3 4
  • Chromosome 14 Open Reading Frame 145 2
  • Chromosome 14 Open Reading Frame 61 2
  • Lens Epithelium-Derived Protein 3
  • Centrosomal Protein Of 128 KDa 3
  • LEDP/132 3
  • Cep128 4

External Ids for CEP128 Gene

Previous HGNC Symbols for CEP128 Gene

  • C14orf61
  • C14orf145

Previous GeneCards Identifiers for CEP128 Gene

  • GC14M080963

Summaries for CEP128 Gene

GeneCards Summary for CEP128 Gene

CEP128 (Centrosomal Protein 128) is a Protein Coding gene.

Additional gene information for CEP128 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEP128 Gene

Genomics for CEP128 Gene

Regulatory Elements for CEP128 Gene

Enhancers for CEP128 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H081218 1.9 FANTOM5 ENCODE dbSUPER 20.2 -261.1 -261135 4 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 GTF2A1 CEP128 LOC101928504 SNORA79 GC14M081203
GH14H080929 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.6 +28.4 28425 2 HDAC1 PKNOX1 ATF1 BATF SCRT2 FOS ATF7 ETV6 RUNX3 CREM CEP128 TSHR PIR53916
GH14H080996 1.1 FANTOM5 Ensembl 17.9 -37.0 -36996 0 CTCF PKNOX1 CEBPG RAD21 SMC3 ZNF143 FOS CREM CEBPB TRIM22 GTF2A1 CEP128 SNORA79 NMNAT1P1 RPL17P3 GC14P080982
GH14H081245 0.9 Ensembl ENCODE 19.2 -287.4 -287400 2 SMARCE1 ZNF687 RFX1 DDX20 SIN3A MNT DPF2 ZNF592 ZNF217 CTBP1 CEP128 GTF2A1 SNORA79 GC14P081247 DYNLL1P1
GH14H081532 1.4 FANTOM5 ENCODE 10.1 -575.3 -575276 4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS CEP128 SEL1L LINC01467
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEP128 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEP128 Gene

Chromosome:
14
Start:
80,476,983 bp from pter
End:
80,959,517 bp from pter
Size:
482,535 bases
Orientation:
Minus strand

Genomic View for CEP128 Gene

Genes around CEP128 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEP128 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEP128 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEP128 Gene

Proteins for CEP128 Gene

  • Protein details for CEP128 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZU80-CE128_HUMAN
    Recommended name:
    Centrosomal protein of 128 kDa
    Protein Accession:
    Q6ZU80
    Secondary Accessions:
    • B9EK52
    • Q86X97
    • Q96ML4

    Protein attributes for CEP128 Gene

    Size:
    1094 amino acids
    Molecular mass:
    128015 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71273.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for CEP128 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEP128 Gene

Post-translational modifications for CEP128 Gene

  • Ubiquitination at Lys814 and posLast=10641064
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEP128 Gene

Domains & Families for CEP128 Gene

Gene Families for CEP128 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CEP128 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEP128 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CEP128: view

No data available for UniProtKB/Swiss-Prot for CEP128 Gene

Function for CEP128 Gene

Phenotypes From GWAS Catalog for CEP128 Gene

genes like me logo Genes that share phenotypes with CEP128: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CEP128
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEP128 Gene

Localization for CEP128 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEP128 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole. Note=Associates with the mother centriole.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEP128 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 3
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEP128 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 21399614
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IDA,IEA 21399614
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CEP128: view

Pathways & Interactions for CEP128 Gene

SuperPathways for CEP128 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEP128 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEP128 Gene

Drugs & Compounds for CEP128 Gene

No Compound Related Data Available

Transcripts for CEP128 Gene

mRNA/cDNA for CEP128 Gene

(9) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEP128 Gene

Centrosomal protein 128kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CEP128
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CEP128 Gene

No ASD Table

Relevant External Links for CEP128 Gene

GeneLoc Exon Structure for
CEP128
ECgene alternative splicing isoforms for
CEP128

Expression for CEP128 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEP128 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEP128 Gene

This gene is overexpressed in Plasma (58.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEP128 Gene



Protein tissue co-expression partners for CEP128 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CEP128 Gene:

CEP128

SOURCE GeneReport for Unigene cluster for CEP128 Gene:

Hs.162889

Evidence on tissue expression from TISSUES for CEP128 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with CEP128: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEP128 Gene

Orthologs for CEP128 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEP128 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEP128 33 34
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia CEP128 33 34
  • 88.32 (n)
cow
(Bos Taurus)
Mammalia CEP128 33
  • 87.21 (n)
-- 34
  • 85 (a)
OneToMany
-- 34
  • 66 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cep128 33 16 34
  • 81.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CEP128 34
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEP128 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEP128 33 34
  • 65.77 (n)
lizard
(Anolis carolinensis)
Reptilia CEP128 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cep128 33
  • 57.39 (n)
zebrafish
(Danio rerio)
Actinopterygii cep128 33 34
  • 52.59 (n)
Species where no ortholog for CEP128 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEP128 Gene

ENSEMBL:
Gene Tree for CEP128 (if available)
TreeFam:
Gene Tree for CEP128 (if available)

Paralogs for CEP128 Gene

genes like me logo Genes that share paralogs with CEP128: view

No data available for Paralogs for CEP128 Gene

Variants for CEP128 Gene

Sequence variations from dbSNP and Humsavar for CEP128 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs121908869 Pathogenic 80,955,802(+) CACCT(C/G)CAAGG intron-variant, reference, missense, utr-variant-5-prime
rs2234919 Likely benign 80,955,834(+) TACCG(A/C/G)CCAGT intron-variant, reference, missense, utr-variant-5-prime
rs61747482 Likely benign 80,955,786(+) AGGAG(C/G)ACTTC intron-variant, reference, missense, utr-variant-5-prime
rs201252762 Uncertain significance 80,955,621(+) GAGGT(A/G)CAGAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs886050853 Uncertain significance 80,955,837(+) CGCCC(A/C)GTACG intron-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CEP128 Gene

Variant ID Type Subtype PubMed ID
dgv1944n100 CNV loss 25217958
dgv667e212 CNV loss 25503493
esv1363737 CNV insertion 17803354
esv2433413 CNV deletion 19546169
esv2515564 CNV deletion 19546169
esv2657436 CNV deletion 23128226
esv2748924 CNV deletion 23290073
esv2761847 CNV loss 21179565
esv3414044 CNV insertion 20981092
esv3581333 CNV loss 25503493
esv3635071 CNV gain 21293372
esv3635075 CNV gain 21293372
esv3635076 CNV gain 21293372
esv3635077 CNV gain 21293372
esv3635078 CNV loss 21293372
esv3635079 CNV loss 21293372
nsv1035295 CNV loss 25217958
nsv456346 CNV loss 19166990
nsv565290 CNV loss 21841781
nsv565291 CNV loss 21841781
nsv832840 CNV gain 17160897
nsv974475 CNV duplication 23825009
nsv976358 CNV duplication 23825009

Variation tolerance for CEP128 Gene

Residual Variation Intolerance Score: 29% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.65; 91.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEP128 Gene

Human Gene Mutation Database (HGMD)
CEP128
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEP128

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEP128 Gene

Disorders for CEP128 Gene

Relevant External Links for CEP128

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEP128

No disorders were found for CEP128 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEP128 Gene

Publications for CEP128 Gene

  1. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PMID: 21399614) Jakobsen L … Andersen JS (The EMBO journal 2011) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division. (PMID: 26748699) Gholkar AA … Torres JZ (Cell reports 2016) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for CEP128 Gene

Sources for CEP128 Gene

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