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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEP128 Gene

protein-coding   GIFtS: 40
GCID: GC14M080963

Centrosomal Protein 128kDa

(Previous names: chromosome 14 open reading frame 61, chromosome 14 open...)
(Previous symbols: C14orf61, C14orf145)
  Search for CEP128
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Centrosomal Protein 128kDa1 2     Chromosome 14 Open Reading Frame 611
C14orf1451 2 3     LEDP/1322
C14orf611 2 3     Centrosomal Protein Of 128 KDa2
Chromosome 14 Open Reading Frame 1451     Lens Epithelium-Derived Protein2

External Ids:    HGNC: 203591   Entrez Gene: 1455082   Ensembl: ENSG000001006297   UniProtKB: Q6ZU803   

Export aliases for CEP128 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CEP128 Gene: 
CEP128 (centrosomal protein 128kDa) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CEP128
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CEP128

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP128


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31.1   Ensembl cytogenetic band:  14q31.1   HGNC cytogenetic band: 14q31.1

CEP128 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP128 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M080963:  view genomic region     (about GC identifiers)

Start:
80,943,330 bp from pter      End:
81,425,861 bp from pter
Size:
482,532 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CE128_HUMAN, Q6ZU80 (See protein sequence)
Recommended Name: Centrosomal protein of 128 kDa  
Size: 1094 amino acids; 128015 Da
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm,
cytoskeleton, spindle pole. Note=Associates with the mother centriole
Sequence caution: Sequence=BAB71273.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B9EK52 Q86X97 Q96ML4
Alternative splicing: 3 isoforms:  Q6ZU80-2   Q6ZU80-1   Q6ZU80-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CEP128: NX_Q6ZU80

Explore proteomics data for CEP128 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ZU80

  • CEP128 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CEP128 Protein Expression
    REFSEQ proteins: NP_689659.2  
    ENSEMBL proteins: 
     ENSP00000451319   ENSP00000451501   ENSP00000451162   ENSP00000451273   ENSP00000450555  
     ENSP00000216517   ENSP00000451137   ENSP00000451214   ENSP00000451849   ENSP00000451428  
     ENSP00000281129   ENSP00000332095  

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    Cloud-Clone Corp. Proteins for CEP128 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA--
    GO:0005814centriole IDA--

    CEP128 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026652 CEP128

    Graphical View of Domain Structure for InterPro Entry Q6ZU80

    ProtoNet protein and cluster: Q6ZU80


    CEP128 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CEP128 
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    SwitchGear 3'UTR luciferase reporter plasmidCEP128 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEP128

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CEP128 (ENSP000002811294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEP128 (CE128)

    Search CenterWatch for drugs/clinical trials and news about CEP128 / CE128

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CEP128 gene: 
    NM_152446.3  

    Unigene Cluster for CEP128:

    Centrosomal protein 128kDa
    Hs.162889  [show with all ESTs]
    Unigene Representative Sequence: HQ215523
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554502(uc010asz.2) ENST00000556061 ENST00000555265 ENST00000553717
    ENST00000557377 ENST00000554728 ENST00000554827(uc001xuy.1) ENST00000216517(uc001xuz.2)
    ENST00000555529(uc001xva.1) ENST00000556042 ENST00000554298(uc010ata.1)
    ENST00000557411 ENST00000556981 ENST00000554368 ENST00000556800 ENST00000281129(uc001xux.2)
    ENST00000327841
    miRNA
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    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate CEP128 (see all 36):
    hsa-miR-142-5p hsa-miR-1321 hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-3162-5p hsa-miR-4275 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidCEP128 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    Additional mRNA sequence: 

    AK056756.1 AK093662.1 AK125925.1 AK309833.1 BC036939.1 BC045834.1 BC150610.1 BX248746.1 
    HQ215523.1 

    10 DOTS entries:

    DT.70103649  DT.75195129  DT.100750166  DT.40285442  DT.99939442  DT.100750165  DT.120771544  DT.75199116 
    DT.92430514  DT.95151244 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEP128 expression in normal human tissues (normalized intensities)      CEP128 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CEP128 Expression
    About this image


    CEP128 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
     
     Oral Cavity (Gastrointestinal Tract)
             saliva   

    See CEP128 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CEP128

    SOURCE GeneReport for Unigene cluster: Hs.162889
        SABiosciences Custom PCR Arrays for CEP128
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEP128
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP128

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CEP128 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cep1281 , 5 RIKEN cDNA 4930534B04 gene5
    centrosomal protein 1281
    81.24(n)1
    78.83(a)1
      12 (44.08 cM)5
    752161  NM_181815.31  NP_861536.31 
     909984925 
    chicken
    (Gallus gallus)
    Aves CEP1281 centrosomal protein 128kDa 65.83(n)
    57.05(a)
      428899  XM_426454.3  XP_426454.3 
    lizard
    (Anolis carolinensis)
    Reptilia CEP1286
    centrosomal protein 128kDa
    54(a)
    1 ↔ 1
    1(17993365-18259911)
    zebrafish
    (Danio rerio)
    Actinopterygii BI673893.12   -- 72.24(n)    BI673893.1 


    ENSEMBL Gene Tree for CEP128 (if available)
    TreeFam Gene Tree for CEP128 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CEP128 gene
    2 SIMAP similar genes for CEP128 using alignment to 10 protein entries:     CE128_HUMAN (see all proteins):
    C14orf145    LEDP/132

    CEP128 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8895 SNPs in CEP128 are shown (see all 8895)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105691891,2
    C--62366598(+) ataat-/AACaaGCC 1 -- int10--------
    rs1818638711,2
    --80962346(+) TCATAA/GTGCTC 1 -- int10--------
    rs48997711,2
    C,F,H--80962356(+) CATTAG/ATACAT 1 -- int131Minor allele frequency- A:0.29EA NA NS CSA WA 2952
    rs111594661,2
    C,F,H--80962369(+) CATTGC/TTCTGA 1 -- int114Minor allele frequency- T:0.08NS EA NA 1298
    rs1860241491,2
    --80962634(+) TGTTAC/TGCAAT 1 -- int10--------
    rs1908255501,2
    --80962735(+) TAAGTC/TAGGAC 1 -- int10--------
    rs1833828111,2
    --80962754(+) TTGAGC/TGGAAG 1 -- int10--------
    rs1878344681,2
    --80962811(+) CAAACA/CCAAAA 1 -- int10--------
    rs1455574091,2
    C--80962862(+) CTATGA/CAGAAT 1 -- ut310--------
    rs1165273721,2
    C,F--80962896(+) CCTGAA/GAGTTT 1 -- ut311Minor allele frequency- G:0.04WA 118

    HapMap Linkage Disequilibrium report for CEP128 (80943330 - 81193330 bp, first 250kb of CEP128)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CEP128:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2433413CNV Deletion19546169
    esv2657436CNV Deletion23128226
    esv2515564CNV Deletion19546169
    esv2748924CNV Deletion23290073
    esv1363737CNV Insertion17803354
    nsv902116CNV Loss21882294
    nsv456346CNV Loss19166990
    nsv832840CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEP128 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CEP128)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PubMed id 21399614)1, 2, 3 Jakobsen L.... Andersen J.S. (2011)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Genome-wide association study identifies novel loci as sociated with concentrations of four plasma phospholipid fatty acids in the de n ovo lipogenesis pathway: results from the Cohorts for Heart and Aging Research i n Genomic Epidemiology (CHARGE) consortium. (PubMed id 23362303)1 Wu J.H....Mozaffarian D. (2013)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Genome-Wide Association Study of Anthropometric Trait s and Evidence of Interactions With Age and Study Year in Filipino Women. (PubMed id 20966902)1 Croteau-Chonka D.C....Mohlke K.L. (2010)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 145508 HGNC: 20359 Ensembl:ENSG00000100629 euGenes: HUgn145508 ECgene: CEP128
    H-InvDB: CEP128

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEP128 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CEP128 gene:
    Search GeneIP for patents involving CEP128

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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