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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CEP128 Gene

protein-coding GIFtS: 37
GCID: GC14M080963

centrosomal protein 128kDa

(Previous names: chromosome 14 open reading frame 61, chromosome 14 open...)
(Previous symbols: C14orf61, C14orf145)

Search for CEP128
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Centrosomal Protein 128kDa¹ ²		Chromosome 14 Open Reading Frame 61¹
C14orf145¹ ² ³		LEDP/132²
C14orf61¹ ² ³		Centrosomal Protein Of 128 KDa²
Chromosome 14 Open Reading Frame 145¹		Lens Epithelium-Derived Protein²

External Ids:	HGNC: 20359¹	Entrez Gene: 145508²	Ensembl: ENSG00000100629⁷	UniProtKB: Q6ZU80³

Export aliases for CEP128 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for CEP128
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for CEP128

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEP128

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31.1 Ensembl cytogenetic band: 14q31.1 HGNC cytogenetic band: 14q31.1

CEP128 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEP128 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M080963: view genomic region (about GC identifiers)

Start:	80,943,330 bp from pter	End:	81,425,861 bp from pter
Size:	482,532 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CE128_HUMAN, Q6ZU80 (See protein sequence)

Recommended Name: Centrosomal protein of 128 kDa

Size: 1094 amino acids; 128015 Da

Subcellular location: Cytoplasm, cytoskeleton, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole.

Note=Associates with the mother centriole

Sequence caution: Sequence=BAB71273.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: B9EK52 Q86X97 Q96ML4

Alternative splicing: 3 isoforms: Q6ZU80-2 Q6ZU80-1 Q6ZU80-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CEP128: NX_Q6ZU80

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6ZU80

CEP128 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_689659.2

ENSEMBL proteins:

ENSP00000451319 ENSP00000451501 ENSP00000451162 ENSP00000451273 ENSP00000450555

ENSP00000216517 ENSP00000451137 ENSP00000451214 ENSP00000451849 ENSP00000451428

ENSP00000281129 ENSP00000332095

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	Uscn Proteins for CEP128

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000922	spindle pole	IDA	--
GO:0005814	centriole	IDA	--

CEP128 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CEP128 for domains About GeneDecksing

1 InterPro domain/family:

IPR026652 CEP128

Graphical View of Domain Structure for InterPro Entry Q6ZU80

ProtoNet protein and cluster: Q6ZU80

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CEP128

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		SwitchGear 3'UTR luciferase reporter plasmid: CEP128 3' UTR sequence

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CEP128

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for CEP128 (ENSP00000281129⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CEP128
Search CenterWatch for drugs/clinical trials and news about CEP128 / CE128

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CEP128 gene:

NM_152446.3

Unigene Cluster for CEP128:

Centrosomal protein 128kDa

Hs.162889 [show with all ESTs]

Unigene Representative Sequence: HQ215523

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000554502(uc010asz.2) ENST00000556061 ENST00000555265 ENST00000553717

ENST00000557377 ENST00000554728 ENST00000554827(uc001xuy.1) ENST00000216517(uc001xuz.2)

ENST00000555529(uc001xva.1) ENST00000556042 ENST00000554298(uc010ata.1)

ENST00000557411 ENST00000556981 ENST00000554368 ENST00000556800 ENST00000281129(uc001xux.2)

ENST00000327841

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		8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate CEP128 (see all 36):
		hsa-miR-142-5p hsa-miR-1321 hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-3162-5p hsa-miR-4275 hsa-miR-372

		SwitchGear 3'UTR luciferase reporter plasmid: CEP128 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AK056756.1 AK093662.1 AK125925.1 AK309833.1 BC036939.1 BC045834.1 BC150610.1 BX248746.1

HQ215523.1

10 DOTS entries:

DT.70103649 DT.75195129 DT.100750166 DT.40285442 DT.99939442 DT.100750165 DT.120771544 DT.75199116

DT.92430514 DT.95151244

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CEP128 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CEP128 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Interscapular Brown Adipose Depot

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CEP128 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEP128

SOURCE GeneReport for Unigene cluster: Hs.162889

SABiosciences Custom PCR Arrays for CEP128

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEP128

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CEP128 gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cep128^{1 , 5}	RIKEN cDNA 4930534B04 gene⁵ centrosomal protein 128¹	81.24(n)¹ 78.83(a)¹		12 (44.08 cM)⁵ 75216¹ NM_181815.3¹ NP_861536.3¹ 90998492⁵
chicken (Gallus gallus)	Aves	CEP128¹	centrosomal protein 128kDa	65.83(n) 57.05(a)		428899 XM_426454.3 XP_426454.3
lizard (Anolis carolinensis)	Reptilia	--	--	56(a)	1 ↔ 1	1(18008189-18125235)
zebrafish (Danio rerio)	Actinopterygii	BI673893.1²	--	72.24(n)		BI673893.1

ENSEMBL Gene Tree for CEP128 (if available)
TreeFam Gene Tree for CEP128 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181863871^1,2		--	80962346(+)	`TCATAA/GTGCTC`	1	--	int¹		0	--	--	--	--
rs4899771^1,2	C,F,H	--	80962356(+)	`CATTAG/ATACAT`	1	--	int¹		31		EA NA NS CSA WA	2952
rs11159466^1,2	C,F,H	--	80962369(+)	`CATTGC/TTCTGA`	1	--	int¹		14		NS EA NA	1298
rs186024149^1,2		--	80962634(+)	`TGTTAC/TGCAAT`	1	--	int¹		0	--	--	--	--
rs190825550^1,2		--	80962735(+)	`TAAGTC/TAGGAC`	1	--	int¹		0	--	--	--	--
rs183382811^1,2		--	80962754(+)	`TTGAGC/TGGAAG`	1	--	int¹		0	--	--	--	--
rs187834468^1,2		--	80962811(+)	`CAAACA/CCAAAA`	1	--	int¹		0	--	--	--	--
rs145557409^1,2		--	80962862(+)	`CTATGA/CAGAAT`	1	--	ut3¹		0	--	--	--	--
rs116527372^1,2	C,F	--	80962896(+)	`CCTGAA/GAGTTT`	1	--	ut3¹		1		WA	118
rs148910396^1,2		--	80962911(+)	`TTACTC/TAGCAT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CEP128 (80943330 - 81193330 bp, first 250kb of CEP128)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CEP128: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEP128

DNA2.0 Custom Variant and Variant Library Synthesis for CEP128

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CEP128 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with CEP128)

Utopia: connect your pdf to the dynamic
world of online information

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. (PubMed id 21399614)^{1, 2, 3} Jakobsen L.... Andersen J.S. (2011)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Genome-Wide Association Study of Anthropometric Trait s and Evidence of Interactions With Age and Study Year in Filipino Women. (PubMed id 20966902)¹ Croteau-Chonka D.C....Mohlke K.L. (2010)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 145508	HGNC: 20359	Ensembl:ENSG00000100629	euGenes: HUgn145508	ECgene: CEP128
H-InvDB: CEP128

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CEP128	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CEP128 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CEP128 gene:
Search GeneIP for patents involving CEP128

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CEP128 gene at Home site.

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CEP128 Gene

centrosomal protein 128kDa

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CEP128 Gene

centrosomal protein 128kDa

Aliasesfor CEP128 gene

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