CENPW Gene
protein-coding GIFtS : 43
GCID: GC06 P126661
centromere protein W (Previous name: chromosome 6 open reading frame 173 ) (Previous symbol: C6orf173 )
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Aliasesfor CENPW gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Centromere Protein W 1 2 CENP-W2 3 C6orf1731 2 3 Chromosome 6 Open Reading Frame 1731 CUG21 2 3 Cancer-Upregulated Gene 22 Cancer-Up-Regulated Gene 2 Protein2 3
Export aliases for CENPW gene to outside databases Previous GC identifer: GC06P124237
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Summariesfor CENPW gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: CENPW_HUMAN, Q5EE01 Function : Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assemblyof kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis
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Genomic Viewsfor CENPW gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000006.11 NC_018917.1 NT_025741.15 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for CENPW Other transcription factors Search SABiosciences Chromatin IP Primers for CENPW Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPW
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 6q22.32 Ensembl cytogenetic band: 6q22.32 HGNC cytogenetic band: 6q22.32 CENPW Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P126661: view genomic region
(about GC identifiers )
Start:
126,661,253 bp from pter
End:
126,670,021 bp from pter
Size:
8,769 bases
Orientation:
plus strand
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Proteinsfor CENPW gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CENPW_HUMAN, Q5EE01 (See
protein sequence )Recommended Name: Centromere protein W Size : 88 amino acids; 10061 Da
Subunit : Part of a centromere complex consisting of CENPA, CENPT and CENPW. Part of a centromere complex consisting ofhistone H3, CENPT and CENPW. Interacts directly with CENPT. Component of a heterotetrameric CENP-T-W-S-X complex composed of APITD1/CENPS, STRA13/CENPX, CENPT and CENPW. Interacts with NPM1. Binds DNA
Subcellular location : Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus matrix. Nucleus,nucleolus. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis
Sequence caution : Sequence=EAW48122.1; Type=Erroneous gene model prediction; Sequence=EAW48123.1; Type=Erroneous genemodel prediction;
Secondary accessions : A6NIR0 A6NJC2Explore the universe of human proteins at neXtProt for CENPW: NX_Q5EE01 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q5EE01 CENPW Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_001012525.1 ENSEMBL proteins: ENSP00000357309 ENSP00000357308 ENSP00000357311 Human Recombinant Protein Products for CENPW: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
CENPW for ontologies About GeneDecksing CENPW Antibody Products: Assay Products for CENPW:
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Protein
Domains / Familiesfor CENPW gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CENPW for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q5EE01 ProtoNet protein and cluster: Q5EE01
UniProtKB/Swiss-Prot: CENPW_HUMAN, Q5EE01 Similarity : Belongs to the CENPW family
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Functionfor CENPW gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: CENPW_HUMAN, Q5EE01 Function : Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assemblyof kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis Induction : Up-regulated in many cancer tissues
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
CENPW for ontologies About GeneDecksing Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CENPW (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CENPWOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CENPW (NM_001012507 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CENPW Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CENPW
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPW
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Pathways & Interactionsfor CENPW gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CENPW STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)2 Interacting proteins for CENPW (ENSP00000357311 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7 ): About this table
CENPW for ontologies About GeneDecksing
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Drugs & Compoundsfor CENPW gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CENPW Search CenterWatch for drugs/clinical trials and news about CENPW
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Transcriptsfor CENPW gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CENPW gene: NM_001012507.2 Unigene Cluster for CENPW:
Centromere protein W Hs.486401 [show with all ESTs ] Unigene Representative Sequence: AL832235 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000368326 ENST00000368325 (uc003qao.3 ) ENST00000368328 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CENPW (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CENPWOriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CENPW (NM_001012507 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CENPW Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CENPW
Additional cDNA sequence: AL832235.1 AY902475.1 BC017928.1 BC039556.2 BC046178.2 BC062798.1
4 DOTS entries : DT.213747 DT.91680946
DT.97837457 DT.100026126 GeneLoc Exon Structure
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Expression for CENPW gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CENPW expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TACTGGCCGCAbout this image CENPW expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Kidney S-shaped Body Kidney Endothelial Cells Endothelium Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor E44 (Embryonic Progenitor Cell)
See CENPW Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CENPW SOURCE GeneReport for Unigene cluster: Hs.486401 UniProtKB/Swiss-Prot: CENPW_HUMAN, Q5EE01 Tissue specificity : Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast andgastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast invasive tumors. Expressed in many cancer cell types SABiosciences Custom PCR Arrays for CENPW Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CENPWBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CENPW QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CENPW QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CENPW In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPW
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Orthologsfor CENPW gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of human and mouse.
Orthologs for CENPW gene from 1/5 species (see all 5 ) About this table
ENSEMBL Gene Tree for CENPW (if available)TreeFam Gene Tree for CENPW (if available)
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Paralogsfor CENPW gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CENPW gene 1 SIMAP similar gene for CENPW using alignment to 1 protein entry: CENPW_HUMAN :C6orf173
CENPW for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for CENPW PGOHUM00000248174
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Genomic Variantsfor CENPW gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 6 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CENPW (126661253 - 126670021 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CENPW: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CENPW
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Disorders
/ Diseasesfor CENPW gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CENPW for disorders About GeneDecksing
OMIM gene information: 611264
OMIM disorders : --3 diseases for CENPW : About MalaCards pediatric crohns disease crohn's disease breast cancer Human Genome Epidemiology (HuGE) Navigator: CENPW (0 documents) Export disorders for CENPW gene to outside databases
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Publicationsfor CENPW gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CENPW gene, integrated from 9 sources (see all 22 ): (articles sorted by number of sources associating them with CENPW) Utopia : connect your pdf to the dynamic world of online information
CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. (PubMed id 19070575) 1 , 2 , 3 Hori T....Fukagawa T. (2008) Molecular cloning and functional analysis of a novel oncogene, cancer-upregulated gene 2 (CUG2). (PubMed id 17610844) 1 , 2 , 3 Lee S.... Koh S.S. (2007) New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein. (PubMed id 22002061) 1 , 2 Chun Y.... Lee S. (2011) Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state. (PubMed id 21695110) 1 , 2 Prendergast L....Sullivan K.F. (2011) Cancer-upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function. (PubMed id 19533040) 1 , 2 Kim H....Lee S. (2009) Replication of loci influencing ages at menarche and m enopause in Hispanic women: the Women's Health Initiative SHARe Study. (PubMed id 22131368) 1 Chen C.T....Franceschini N. (2012) Common variants at 6q22 and 17q21 are associated with intracranial volume. (PubMed id 22504418) 1 Ikram M.A....DeCarli C. (2012) CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold. (PubMed id 22304917) 2 Nishino T.... Fukagawa T. (2012) The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612) 1 Zhao J....Grant S.F. (2010) Cancer-upregulated gene 2 (CUG2) overexpression induc es apoptosis in SKOV-3 cells. (PubMed id 20648695) 1 Lee S....Lee S. (2010)
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External Searches for CENPW gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CENPW gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CENPW gene
(According to HUGE )
About This Section --
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Specialized Databases showing CENPW gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CENPW Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CENPW gene: Search GeneIP for patents involving CENPW GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CENPW gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CENPW OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CENPW OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CENPW OriGene Protein Over-expression Lysate for CENPW Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CENPW OriGene 3'-UTR Clone for CENPW OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CENPW OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CENPW Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CENPW OriGene Custom Protein Services for CENPW OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CENPW QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CENPW QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPW QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CENPW QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CENPW QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CENPW
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CENPW Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPW
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CENPW
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Aliases for CENPW
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Disorders / Diseases for CENPW
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Expression for CENPW
Function for CENPW
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