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CENPW Gene

protein-coding   GIFtS: 44
GCID: GC06P126661

Centromere Protein W

(Previous name: chromosome 6 open reading frame 173)
(Previous symbol: C6orf173)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centromere Protein W1 2     Cancer-Up-Regulated Gene 2 Protein2 3
C6orf1731 2 3 5     CENP-W2 3
CUG22 3 5     Chromosome 6 Open Reading Frame 1731
Cancer-Upregulated Gene 21 2     CEMPW5

External Ids:    HGNC: 214881   Entrez Gene: 3871032   Ensembl: ENSG000002037607   OMIM: 6112645   UniProtKB: Q5EE013   

Export aliases for CENPW gene to outside databases

Previous GC identifer: GC06P124237


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CENPW Gene:
CENPW (centromere protein W) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot: CENPW_HUMAN, Q5EE01
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in
assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC
complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly
synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds
specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA.
Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role
in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the
inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome
organization and normal progress through mitosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CENPW
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CENPW


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.32   Ensembl cytogenetic band:  6q22.32   HGNC cytogenetic band: 6q22.32

CENPW Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPW gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P126661:  view genomic region     (about GC identifiers)

Start:
126,661,253 bp from pter      End:
126,670,021 bp from pter
Size:
8,769 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CENPW_HUMAN, Q5EE01 (See protein sequence)
Recommended Name: Centromere protein W  
Size: 88 amino acids; 10061 Da
Subunit: Part of a centromere complex consisting of CENPA, CENPT and CENPW. Part of a centromere complex
consisting of histone H3, CENPT and CENPW. Interacts directly with CENPT. Component of a heterotetrameric
CENP-T-W-S-X complex composed of APITD1/CENPS, STRA13/CENPX, CENPT and CENPW. Interacts with NPM1. Binds DNA
Sequence caution: Sequence=EAW48122.1; Type=Erroneous gene model prediction; Sequence=EAW48123.1; Type=Erroneous
gene model prediction;
Secondary accessions: A6NIR0 A6NJC2

Explore the universe of human proteins at neXtProt for CENPW: NX_Q5EE01

REFSEQ proteins (3 alternative transcripts): 
NP_001012525.1  NP_001273453.1  NP_001273454.1  

ENSEMBL proteins: 
 ENSP00000357309   ENSP00000357308   ENSP00000357311  

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antibodies-online peptides for CENPW

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR009072 Histone-fold
 IPR028847 CENP-W

Graphical View of Domain Structure for InterPro Entry Q5EE01

ProtoNet protein and cluster: Q5EE01

UniProtKB/Swiss-Prot: CENPW_HUMAN, Q5EE01
Similarity: Belongs to the CENPW family


Find genes that share domains with CENPW           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CENPW_HUMAN, Q5EE01
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in
assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC
complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly
synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds
specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA.
Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role
in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the
inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome
organization and normal progress through mitosis
Induction: Up-regulated in many cancer tissues

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding IEA--
GO:0005515protein binding IPI19070575
GO:0046982protein heterodimerization activity IEA--
     
Find genes that share ontologies with CENPW           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CENPW_HUMAN, Q5EE01: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus matrix.
Nucleus, nucleolus. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner
kinetochore during mitosis
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
cytosol2
mitochondrion1

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000775chromosome, centromeric region IDA19533040
GO:0000776kinetochore IDA--
GO:0000777condensed chromosome kinetochore IEA--
GO:0005730nucleolus IEA--
GO:0016363nuclear matrix IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CENPW
Interactions:

    Search GeneGlobe Interaction Network for CENPW

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for CENPW (ENSP000003573114) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CENPTENSP000002191724STRING: ENSP00000219172
CORTENSP000003171104STRING: ENSP00000317110
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000278mitotic cell cycle IMP--
GO:0007059chromosome segregation TAS19533040
GO:0007067mitosis IEA--
GO:0034080CENP-A containing nucleosome assembly at centromere TAS19533040
GO:0051276chromosome organization IMP--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CENPW



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CENPW gene (3 alternative transcripts): 
NM_001012507.3  NM_001286524.1  NM_001286525.1  

Unigene Cluster for CENPW:

Centromere protein W
Hs.486401  [show with all ESTs]
Unigene Representative Sequence: AL832235
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000368326 ENST00000368325(uc003qao.3) ENST00000368328
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Additional mRNA sequence: 

AL832235.1 AY902475.1 BC017928.1 BC039556.2 BC046178.2 BC062798.1 

4 DOTS entries:

DT.213747  DT.91680946  DT.97837457  DT.100026126 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CENPW expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TACTGGCCGC
CENPW Expression
About this image


CENPW expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Heart (Cardiovascular System)
         Cardiac Fibroblasts Myocardium
 
 Fibroblasts
         Cardiac Fibroblasts Myocardium
CENPW Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.486401

UniProtKB/Swiss-Prot: CENPW_HUMAN, Q5EE01
Tissue specificity: Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and
gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade
breast invasive tumors. Expressed in many cancer cell types

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CENPW gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cenpw1 , 5 centromere protein W1, 5 78.68(n)1
73.26(a)1
  10 (16.93 cM)5
663111  NM_001109747.11  NP_001103217.11 
 301960115 
chicken
(Gallus gallus)
Aves CENPW1 centromere protein W 67.11(n)
60.53(a)
  421716  NM_001277733.1  NP_001264662.1 


ENSEMBL Gene Tree for CENPW (if available)
TreeFam Gene Tree for CENPW (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CENPW gene
1 SIMAP similar gene for CENPW using alignment to 1 protein entry:     CENPW_HUMAN:
C6orf173

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1 Pseudogenes.org Pseudogene for CENPW
PGOHUM00000248174


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CENPW (see all 186)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 6 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1146634141,2
F--126659293(+) GAAAAT/GTGGCC 1 -- us2k11Minor allele frequency- G:0.04WA 118
rs1393860481,2
--126659365(+) AGCTAC/GAAAAG 1 -- us2k10--------
rs1812436481,2
--126659400(+) GAATAA/GGCGAA 1 -- us2k10--------
rs755207931,2
C,F--126659548(+) AAAAAA/TTTGGC 1 -- us2k11Minor allele frequency- T:0.08WA 118
rs1426957711,2
--126659569(+) AATTCA/GTGAAG 1 -- us2k10--------
rs1858064561,2
--126659737(+) TTTTTA/TAAATT 1 -- us2k10--------
rs1905217491,2
--126659774(+) CACTGC/GAGATT 1 -- us2k10--------
rs1816495191,2
--126659989(+) ATAGAC/TTGAGA 1 -- us2k10--------
rs1460356491,2
--126660055(+) TGGCTA/GTAAAG 1 -- us2k10--------
rs1395555721,2
--126660298(+) TAAAGA/GTATTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CENPW (126661253 - 126670021 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for CENPW:    About this table    
Variant IDTypeSubtypePubMed ID
nsv5468CNV Insertion18451855

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CENPW
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611264    OMIM disorders: --


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Genetic Association Database (GAD): CENPW
Human Genome Epidemiology (HuGE) Navigator: CENPW (0 documents)

Export disorders for CENPW gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CENPW gene, integrated from 10 sources (see all 28):
(articles sorted by number of sources associating them with CENPW)
    Utopia: connect your pdf to the dynamic
world of online information

  1. CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. (PubMed id 19070575)1, 2, 3 Hori T....Fukagawa T. (Cell 2008)
  2. Molecular cloning and functional analysis of a novel oncogene, cancer-upregulated gene 2 (CUG2). (PubMed id 17610844)1, 2, 3 Lee S.... Koh S.S. (Biochem. Biophys. Res. Commun. 2007)
  3. Common variants at 6q22 and 17q21 are associated with intracranial volume. (PubMed id 22504418)1, 4 Ikram M.A....DeCarli C. (Nat. Genet. 2012)
  4. New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein. (PubMed id 22002061)1, 2 Chun Y.... Lee S. (J. Biol. Chem. 2011)
  5. Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state. (PubMed id 21695110)1, 2 Prendergast L.... Sullivan K.F. (PLoS Biol. 2011)
  6. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (Nat. Genet. 2010)
  7. Cancer-upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function. (PubMed id 19533040)1, 2 Kim H.... Lee S. (Mol. Cells 2009)
  8. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)1, 4 Barrett J.C....Rich S.S. (Nat. Genet. 2009)
  9. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
  10. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (Nat. Genet. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 387103 HGNC: 21488 Ensembl:ENSG00000203760 euGenes: HUgn387103 ECgene: CENPW
H-InvDB: CENPW

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CENPW Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CENPW gene:
Search GeneIP for patents involving CENPW

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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 antibodies-online antibodies for CENPW (9 products)
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 antibodies-online proteins for CENPW (3 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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