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Aliases for CENPW Gene

Aliases for CENPW Gene

  • Centromere Protein W 2 3
  • C6orf173 3 4 6
  • CUG2 3 4 6
  • Cancer-Up-Regulated Gene 2 Protein 3 4
  • Cancer-Upregulated Gene 2 2 3
  • CENP-W 3 4
  • Chromosome 6 Open Reading Frame 173 2
  • CEMPW 6

External Ids for CENPW Gene

Previous Symbols for CENPW Gene

  • C6orf173

Summaries for CENPW Gene

GeneCards Summary for CENPW Gene

CENPW (Centromere Protein W) is a Protein Coding gene. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for CENPW Gene

  • Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPW Gene

Genomics for CENPW Gene

Genomic Location for CENPW Gene

Start:
126,339,789 bp from pter
End:
126,483,320 bp from pter
Size:
143,532 bases
Orientation:
Plus strand

Genomic View for CENPW Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CENPW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPW Gene

No data available for Regulatory Elements for CENPW Gene

Proteins for CENPW Gene

  • Protein details for CENPW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EE01-CENPW_HUMAN
    Recommended name:
    Centromere protein W
    Protein Accession:
    Q5EE01
    Secondary Accessions:
    • A6NIR0
    • A6NJC2

    Protein attributes for CENPW Gene

    Size:
    88 amino acids
    Molecular mass:
    10061 Da
    Quaternary structure:
    • Part of a centromere complex consisting of CENPA, CENPT and CENPW. Part of a centromere complex consisting of histone H3, CENPT and CENPW. Interacts directly with CENPT. Component of a heterotetrameric CENP-T-W-S-X complex composed of APITD1/CENPS, STRA13/CENPX, CENPT and CENPW. Interacts with NPM1. Binds DNA.
    SequenceCaution:
    • Sequence=EAW48122.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW48123.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CENPW Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPW Gene

Proteomics data for CENPW Gene at MOPED

Post-translational modifications for CENPW Gene

No Post-translational modifications

Other Protein References for CENPW Gene

No data available for DME Specific Peptides for CENPW Gene

Domains for CENPW Gene

Protein Domains for CENPW Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPW Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5EE01

UniProtKB/Swiss-Prot:

CENPW_HUMAN
Family:
  • Belongs to the CENPW family.:
    • Q5EE01
genes like me logo Genes that share domains with CENPW: view

No data available for Gene Families for CENPW Gene

Function for CENPW Gene

Molecular function for CENPW Gene

UniProtKB/Swiss-Prot Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.
UniProtKB/Swiss-Prot Induction: Up-regulated in many cancer tissues.

Gene Ontology (GO) - Molecular Function for CENPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 19070575
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with CENPW: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CENPW Gene

Localization for CENPW Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPW Gene

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus matrix. Nucleus, nucleolus. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPW Gene COMPARTMENTS Subcellular localization image for CENPW gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CENPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 19533040
GO:0000776 kinetochore IDA 21695110
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CENPW: view

Pathways for CENPW Gene

SuperPathways for CENPW Gene

No Data Available

Interacting Proteins for CENPW Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357311%0d%0a9606.ENSP00000219172%0d%0a9606.ENSP00000350512%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000308583%0d%0a
Selected Interacting proteins: ENSP00000357311 for CENPW Gene via STRING

Gene Ontology (GO) - Biological Process for CENPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IMP 21695110
GO:0006334 nucleosome assembly TAS --
GO:0007059 chromosome segregation TAS 19533040
GO:0007067 mitotic nuclear division IEA --
GO:0034080 CENP-A containing nucleosome assembly TAS 19533040
genes like me logo Genes that share ontologies with CENPW: view

No data available for Pathways by source for CENPW Gene

Transcripts for CENPW Gene

mRNA/cDNA for CENPW Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CENPW Gene

Centromere protein W:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CENPW Gene

No ASD Table

Relevant External Links for CENPW Gene

GeneLoc Exon Structure for
CENPW
ECgene alternative splicing isoforms for
CENPW

Expression for CENPW Gene

mRNA expression in normal human tissues for CENPW Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CENPW Gene

This gene is overexpressed in Testis (5.0).

SOURCE GeneReport for Unigene cluster for CENPW Gene Hs.486401

mRNA Expression by UniProt/SwissProt for CENPW Gene

Q5EE01-CENPW_HUMAN
Tissue specificity: Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast invasive tumors. Expressed in many cancer cell types.
genes like me logo Genes that share expressions with CENPW: view

No data available for Protein expression for CENPW Gene

Orthologs for CENPW Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPW Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPW 35
  • 99.62 (n)
  • 100 (a)
CENPW 36
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C6ORF173 36
  • 86 (a)
OneToOne
CENPW 35
  • 86.74 (n)
  • 86.36 (a)
dog
(Canis familiaris)
Mammalia CENPW 35
  • 80.3 (n)
  • 73.86 (a)
CENPW 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cenpw 35
  • 78.68 (n)
  • 73.26 (a)
Cenpw 16
Cenpw 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpw 35
  • 76.36 (n)
  • 73.26 (a)
chicken
(Gallus gallus)
Aves CENPW 35
  • 67.11 (n)
  • 60.53 (a)
CENPW 36
  • 51 (a)
OneToOne
Species with no ortholog for CENPW:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CENPW Gene

ENSEMBL:
Gene Tree for CENPW (if available)
TreeFam:
Gene Tree for CENPW (if available)

Paralogs for CENPW Gene

Selected SIMAP similar genes for CENPW Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CENPW Gene

genes like me logo Genes that share paralogs with CENPW: view

No data available for Paralogs for CENPW Gene

Variants for CENPW Gene

Sequence variations from dbSNP and Humsavar for CENPW Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs470460 -- 126,409,248(-) caata(A/G)tgaga intron-variant
rs470507 -- 126,410,230(-) agaaa(C/T)aaaat intron-variant
rs470525 -- 126,409,490(-) ggata(C/G)ataat intron-variant
rs489475 -- 126,409,125(-) ctatg(A/G)gatat intron-variant
rs576049 -- 126,409,397(-) agctg(A/C)agaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPW Gene

Variant ID Type Subtype PubMed ID
nsv5468 CNV Insertion 18451855

Relevant External Links for CENPW Gene

HapMap Linkage Disequilibrium report
CENPW

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPW Gene

Disorders for CENPW Gene

Relevant External Links for CENPW

Genetic Association Database (GAD)
CENPW
Human Genome Epidemiology (HuGE) Navigator
CENPW
genes like me logo Genes that share disorders with CENPW: view

No data available for UniProtKB/Swiss-Prot for CENPW Gene

Publications for CENPW Gene

  1. Molecular cloning and functional analysis of a novel oncogene, cancer-upregulated gene 2 (CUG2). (PMID: 17610844) Lee S. … Koh S.S. (Biochem. Biophys. Res. Commun. 2007) 2 3 4
  2. CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. (PMID: 19070575) Hori T. … Fukagawa T. (Cell 2008) 2 3 4
  3. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48
  4. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 48
  5. Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state. (PMID: 21695110) Prendergast L. … Sullivan K.F. (PLoS Biol. 2011) 3 4

Products for CENPW Gene

Sources for CENPW Gene

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