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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CENPW Gene

protein-coding   GIFtS: 43
GCID: GC06P126661

centromere protein W

(Previous name: chromosome 6 open reading frame 173 )
(Previous symbol: C6orf173)
 Explore 3 diseases affiliated with
CENPW via our new
 Human Malady Compendium 
Biological research products
for CENPW
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Centromere Protein W1 2     CENP-W2 3
C6orf1731 2 3     Chromosome 6 Open Reading Frame 1731
CUG21 2 3     Cancer-Upregulated Gene 22
Cancer-Up-Regulated Gene 2 Protein2 3     

External Ids:    HGNC: 214881   Entrez Gene: 3871032   Ensembl: ENSG000002037607   OMIM: 6112645   UniProtKB: Q5EE013   

Export aliases for CENPW gene to outside databases

Previous GC identifer: GC06P124237


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CENPW_HUMAN, Q5EE01
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly
of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex
recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA
into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone
H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the
heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore
assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore
proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal
progress through mitosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_025741.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CENPW
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPW


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.32   Ensembl cytogenetic band:  6q22.32   HGNC cytogenetic band: 6q22.32

CENPW Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPW gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P126661:  view genomic region     (about GC identifiers)

Start:
126,661,253 bp from pter      End:
126,670,021 bp from pter
Size:
8,769 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CENPW_HUMAN, Q5EE01 (See protein sequence)
Recommended Name: Centromere protein W  
Size: 88 amino acids; 10061 Da
Subunit: Part of a centromere complex consisting of CENPA, CENPT and CENPW. Part of a centromere complex consisting of
histone H3, CENPT and CENPW. Interacts directly with CENPT. Component of a heterotetrameric CENP-T-W-S-X complex
composed of APITD1/CENPS, STRA13/CENPX, CENPT and CENPW. Interacts with NPM1. Binds DNA
Subcellular location: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus matrix. Nucleus,
nucleolus. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during
mitosis
Sequence caution: Sequence=EAW48122.1; Type=Erroneous gene model prediction; Sequence=EAW48123.1; Type=Erroneous gene
model prediction;
Secondary accessions: A6NIR0 A6NJC2

Explore the universe of human proteins at neXtProt for CENPW: NX_Q5EE01

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5EE01

  • CENPW Protein expression data from MOPED and PaxDb:    About this image 
    CENPW Protein Expression
    REFSEQ proteins: NP_001012525.1  
    ENSEMBL proteins: 
     ENSP00000357309   ENSP00000357308   ENSP00000357311  

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    Uscn Proteins for CENPW

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA19533040
    GO:0000776kinetochore IDA--
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005730nucleolus IEA--
    GO:0016363nuclear matrix IEA--

    CENPW for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CENPW for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR009072 Histone-fold

    Graphical View of Domain Structure for InterPro Entry Q5EE01

    ProtoNet protein and cluster: Q5EE01

    UniProtKB/Swiss-Prot: CENPW_HUMAN, Q5EE01
    Similarity: Belongs to the CENPW family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPW_HUMAN, Q5EE01
    Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly
    of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex
    recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA
    into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone
    H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the
    heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore
    assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore
    proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal
    progress through mitosis
    Induction: Up-regulated in many cancer tissues

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI19533040
    GO:0046982protein heterodimerization activity IEA--
         
    CENPW for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPW


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CENPW

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CENPW (ENSP000003573114) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CENPTENSP000002191724STRING: ENSP00000219172
    CORTENSP000003171104STRING: ENSP00000317110
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle IMP--
    GO:0007059chromosome segregation TAS19533040
    GO:0007067mitosis IEA--
    GO:0034080CENP-A containing nucleosome assembly at centromere TAS19533040
    GO:0051276chromosome organization IMP--

    CENPW for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CENPW
    Search CenterWatch for drugs/clinical trials and news about CENPW 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CENPW gene: 
    NM_001012507.2  

    Unigene Cluster for CENPW:

    Centromere protein W
    Hs.486401  [show with all ESTs]
    Unigene Representative Sequence: AL832235
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368326 ENST00000368325(uc003qao.3) ENST00000368328

    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CENPW
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    Additional cDNA sequence: 

    AL832235.1 AY902475.1 BC017928.1 BC039556.2 BC046178.2 BC062798.1 

    4 DOTS entries:

    DT.213747  DT.91680946  DT.97837457  DT.100026126 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CENPW expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TACTGGCCGC
    CENPW Expression
    About this image

    CENPW expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)

    See CENPW Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CENPW

    SOURCE GeneReport for Unigene cluster: Hs.486401

    UniProtKB/Swiss-Prot: CENPW_HUMAN, Q5EE01
    Tissue specificity: Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and
    gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast
    invasive tumors. Expressed in many cancer cell types

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CENPW gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenpw1 , 5 centromere protein W1, 5 78.68(n)1
    73.26(a)1
      10 (16.93 cM)5
    663111  NM_001109747.11  NP_001103217.11 
     301960115 


    ENSEMBL Gene Tree for CENPW (if available)
    TreeFam Gene Tree for CENPW (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CENPW gene
    1 SIMAP similar gene for CENPW using alignment to 1 protein entry:     CENPW_HUMAN:
    C6orf173

    CENPW for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CENPW
    PGOHUM00000248174


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/154 NCBI SNPs in CENPW are shown (see all 154    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1146634141,2
    F--126659293(+) GAAAAT/GTGGCC 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1393860481,2
    --126659365(+) AGCTAC/GAAAAG 1 -- us2k10--------
    rs1812436481,2
    --126659400(+) GAATAA/GGCGAA 1 -- us2k10--------
    rs755207931,2
    F--126659548(+) AAAAAA/TTTGGC 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs1426957711,2
    --126659569(+) AATTCA/GTGAAG 1 -- us2k10--------
    rs1858064561,2
    --126659737(+) TTTTTA/TAAATT 1 -- us2k10--------
    rs1905217491,2
    --126659774(+) CACTGC/GAGATT 1 -- us2k10--------
    rs1816495191,2
    --126659989(+) ATAGAC/TTGAGA 1 -- us2k10--------
    rs1460356491,2
    --126660055(+) TGGCTA/GTAAAG 1 -- us2k10--------
    rs1395555721,2
    --126660298(+) TAAAGA/GTATTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CENPW (126661253 - 126670021 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CENPW: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CENPW
    DNA2.0 Custom Variant and Variant Library Synthesis for CENPW

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CENPW for disorders           About GeneDecksing

    OMIM gene information: 611264    OMIM disorders: --

    3 diseases for CENPW:    About MalaCards
    pediatric crohns disease    crohn's disease    breast cancer

    Human Genome Epidemiology (HuGE) Navigator: CENPW (0 documents)

    Export disorders for CENPW gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CENPW gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with CENPW)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. (PubMed id 19070575)1, 2, 3 Hori T....Fukagawa T. (2008)
    2. Molecular cloning and functional analysis of a novel oncogene, cancer-upregulated gene 2 (CUG2). (PubMed id 17610844)1, 2, 3 Lee S.... Koh S.S. (2007)
    3. New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein. (PubMed id 22002061)1, 2 Chun Y.... Lee S. (2011)
    4. Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state. (PubMed id 21695110)1, 2 Prendergast L....Sullivan K.F. (2011)
    5. Cancer-upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function. (PubMed id 19533040)1, 2 Kim H....Lee S. (2009)
    6. Replication of loci influencing ages at menarche and m enopause in Hispanic women: the Women's Health Initiative SHARe Study. (PubMed id 22131368)1 Chen C.T....Franceschini N. (2012)
    7. Common variants at 6q22 and 17q21 are associated with intracranial volume. (PubMed id 22504418)1 Ikram M.A....DeCarli C. (2012)
    8. CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold. (PubMed id 22304917)2 Nishino T.... Fukagawa T. (2012)
    9. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)1 Zhao J....Grant S.F. (2010)
    10. Cancer-upregulated gene 2 (CUG2) overexpression induc es apoptosis in SKOV-3 cells. (PubMed id 20648695)1 Lee S....Lee S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 387103 HGNC: 21488 Ensembl:ENSG00000203760 euGenes: HUgn387103 ECgene: CENPW
    H-InvDB: CENPW

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CENPW Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CENPW gene:
    Search GeneIP for patents involving CENPW

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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    von Willebrand factor
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