Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CENPW Gene

Aliases for CENPW Gene

  • Centromere Protein W 2 3 5
  • Cancer-Up-Regulated Gene 2 Protein 3 4
  • Cancer-Upregulated Gene 2 2 3
  • C6orf173 3 4
  • CENP-W 3 4
  • CUG2 3 4
  • Chromosome 6 Open Reading Frame 173 2

External Ids for CENPW Gene

Previous HGNC Symbols for CENPW Gene

  • C6orf173

Previous GeneCards Identifiers for CENPW Gene

  • GC06P126661
  • GC06P124237

Summaries for CENPW Gene

GeneCards Summary for CENPW Gene

CENPW (Centromere Protein W) is a Protein Coding gene. Among its related pathways are Chromosome Maintenance and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for CENPW Gene

  • Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.

Additional gene information for CENPW Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPW Gene

Genomics for CENPW Gene

Regulatory Elements for CENPW Gene

Enhancers for CENPW Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H125779 1.7 Ensembl ENCODE dbSUPER 20.7 -558.3 -558292 3 HNRNPUL1 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 HEY2 CENPW RNF217 TRMT11 RNF217-AS1 NCOA7 NCOA7-AS1
GH06H125940 2 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -394.9 -394873 9 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B FEZF1 DMAP1 YY1 ZNF766 RNF217 CENPW NCOA7-AS1 LOC105377986 HEY2 NCOA7 TRMT11 PIR42096 HINT3
GH06H125955 1.8 FANTOM5 ENCODE dbSUPER 14.3 -382.7 -382729 3 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZC3H11A TRMT11 CENPW NCOA7 HINT3 RNA5SP216
GH06H127265 1.4 ENCODE dbSUPER 14.3 +928.0 927978 3 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 ECHDC1 CENPW RNF146 LOC105377994
GH06H126180 1.2 Ensembl ENCODE 10.4 -157.8 -157820 3 PKNOX1 ZFP64 INSM2 BMI1 BATF RAD21 RARA RFX5 ZNF366 FOS TRMT11 CENPW GC06P126193 LOC101928096
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CENPW on UCSC Golden Path with GeneCards custom track

Promoters for CENPW Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000202318 612 1600 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF143 SP3 SP5 ZHX2

Genomic Location for CENPW Gene

Chromosome:
6
Start:
126,339,789 bp from pter
End:
126,483,320 bp from pter
Size:
143,532 bases
Orientation:
Plus strand

Genomic View for CENPW Gene

Genes around CENPW on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPW Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPW Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPW Gene

Proteins for CENPW Gene

  • Protein details for CENPW Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EE01-CENPW_HUMAN
    Recommended name:
    Centromere protein W
    Protein Accession:
    Q5EE01
    Secondary Accessions:
    • A6NIR0
    • A6NJC2

    Protein attributes for CENPW Gene

    Size:
    88 amino acids
    Molecular mass:
    10061 Da
    Quaternary structure:
    • Heterodimer with CENPT; this dimer coassembles with CENPS-CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex, which is a subcomplex of the large constitutive centromere-associated network (CCAN, also known as the interphase centromere complex or ICEN) (PubMed:19070575, PubMed:19533040, PubMed:21695110, PubMed:22304917). Interacts with NPM1 (PubMed:22002061).
    SequenceCaution:
    • Sequence=EAW48122.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW48123.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CENPW Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPW Gene

Post-translational modifications for CENPW Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CENPW Gene

No data available for DME Specific Peptides for CENPW Gene

Domains & Families for CENPW Gene

Gene Families for CENPW Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CENPW Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPW Gene

Graphical View of Domain Structure for InterPro Entry

Q5EE01

UniProtKB/Swiss-Prot:

CENPW_HUMAN :
  • Belongs to the CENPW family.
Family:
  • Belongs to the CENPW family.
genes like me logo Genes that share domains with CENPW: view

Function for CENPW Gene

Molecular function for CENPW Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.

Phenotypes From GWAS Catalog for CENPW Gene

Gene Ontology (GO) - Molecular Function for CENPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 19070575
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with CENPW: view

Phenotypes for CENPW Gene

GenomeRNAi human phenotypes for CENPW:
genes like me logo Genes that share phenotypes with CENPW: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CENPW
  • Applied Biological Materials Clones for CENPW
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CENPW Gene

Localization for CENPW Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPW Gene

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Nucleus matrix. Nucleus, nucleolus. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis. {ECO:0000250 UniProtKB:P0DJH6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPW gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CENPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA,IDA 19533040
GO:0000776 kinetochore IDA,IEA 21695110
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CENPW: view

Pathways & Interactions for CENPW Gene

genes like me logo Genes that share pathways with CENPW: view

Gene Ontology (GO) - Biological Process for CENPW Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IMP 21695110
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation TAS 19533040
GO:0034080 CENP-A containing nucleosome assembly TAS 19533040
GO:0051276 chromosome organization IMP 21695110
genes like me logo Genes that share ontologies with CENPW: view

No data available for SIGNOR curated interactions for CENPW Gene

Drugs & Compounds for CENPW Gene

No Compound Related Data Available

Transcripts for CENPW Gene

mRNA/cDNA for CENPW Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CENPW Gene

Centromere protein W:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CENPW
  • Applied Biological Materials Clones for CENPW
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CENPW Gene

No ASD Table

Relevant External Links for CENPW Gene

GeneLoc Exon Structure for
CENPW
ECgene alternative splicing isoforms for
CENPW

Expression for CENPW Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CENPW Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CENPW Gene

This gene is overexpressed in Testis (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of CENPW Gene:

CENPW

SOURCE GeneReport for Unigene cluster for CENPW Gene:

Hs.486401

mRNA Expression by UniProt/SwissProt for CENPW Gene:

Q5EE01-CENPW_HUMAN
Tissue specificity: Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast invasive tumors. Expressed in many cancer cell types.

Evidence on tissue expression from TISSUES for CENPW Gene

  • Lung(4.2)
  • Stomach(4.1)
  • Kidney(4)
genes like me logo Genes that share expression patterns with CENPW: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPW Gene

Orthologs for CENPW Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPW Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPW 33 34
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia CENPW 33
  • 86.74 (n)
C6ORF173 34
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CENPW 33 34
  • 80.3 (n)
mouse
(Mus musculus)
Mammalia Cenpw 33 16 34
  • 78.68 (n)
rat
(Rattus norvegicus)
Mammalia Cenpw 33
  • 76.36 (n)
chicken
(Gallus gallus)
Aves CENPW 33 34
  • 67.11 (n)
Species where no ortholog for CENPW was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CENPW Gene

ENSEMBL:
Gene Tree for CENPW (if available)
TreeFam:
Gene Tree for CENPW (if available)

Paralogs for CENPW Gene

(1) SIMAP similar genes for CENPW Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CENPW Gene

genes like me logo Genes that share paralogs with CENPW: view

No data available for Paralogs for CENPW Gene

Variants for CENPW Gene

Sequence variations from dbSNP and Humsavar for CENPW Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000011400 -- 126,405,917(+) TCCAT(A/G/T)TATAA intron-variant
rs1000022225 -- 126,447,964(+) TATTA(C/T)TCGCT intron-variant
rs1000030430 -- 126,448,312(+) TGGTA(C/T)TTAAT intron-variant
rs1000036348 -- 126,361,228(+) GGCGC(G/T)TAAGA intron-variant
rs1000064610 -- 126,399,018(+) ATTCC(A/G/T)TTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPW Gene

Variant ID Type Subtype PubMed ID
esv2678315 CNV deletion 23128226
nsv473017 CNV novel sequence insertion 20440878
nsv5468 CNV insertion 18451855
nsv970162 CNV duplication 23825009

Variation tolerance for CENPW Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CENPW Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPW

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPW Gene

Disorders for CENPW Gene

Relevant External Links for CENPW

Genetic Association Database (GAD)
CENPW
Human Genome Epidemiology (HuGE) Navigator
CENPW
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPW

No disorders were found for CENPW Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPW Gene

Publications for CENPW Gene

  1. CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. (PMID: 19070575) Hori T … Fukagawa T (Cell 2008) 2 3 4 60
  2. Molecular cloning and functional analysis of a novel oncogene, cancer-upregulated gene 2 (CUG2). (PMID: 17610844) Lee S … Koh SS (Biochemical and biophysical research communications 2007) 2 3 4 60
  3. Common variants at 6q22 and 17q21 are associated with intracranial volume. (PMID: 22504418) Ikram MA … Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (Nature genetics 2012) 3 45 60
  4. New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein. (PMID: 22002061) Chun Y … Lee S (The Journal of biological chemistry 2011) 3 4 60
  5. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A … Haiman CA (PLoS genetics 2011) 3 45 60

Products for CENPW Gene

  • Addgene plasmids for CENPW

Sources for CENPW Gene

Content
Loading form....