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Aliases for CENPV Gene

Aliases for CENPV Gene

  • Centromere Protein V 2 3 5
  • Proline-Rich Protein 6 3 4
  • Nuclear Protein P30 3 4
  • Proline Rich 6 2 3
  • CENP-V 3 4
  • PRR6 3 4
  • 3110013H01Rik 3
  • P30 3

External Ids for CENPV Gene

Previous HGNC Symbols for CENPV Gene

  • PRR6

Previous GeneCards Identifiers for CENPV Gene

  • GC17M016189
  • GC17M016245

Summaries for CENPV Gene

GeneCards Summary for CENPV Gene

CENPV (Centromere Protein V) is a Protein Coding gene. Diseases associated with CENPV include Intracranial Primitive Neuroectodermal Tumor and Diffuse Glomerulonephritis. GO annotations related to this gene include carbon-sulfur lyase activity. An important paralog of this gene is CENPVP2.

UniProtKB/Swiss-Prot for CENPV Gene

  • Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPV Gene

Genomics for CENPV Gene

Regulatory Elements for CENPV Gene

Enhancers for CENPV Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CENPV on UCSC Golden Path with GeneCards custom track

Promoters for CENPV Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CENPV on UCSC Golden Path with GeneCards custom track

Genomic Location for CENPV Gene

16,342,534 bp from pter
16,353,656 bp from pter
11,123 bases
Minus strand

Genomic View for CENPV Gene

Genes around CENPV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPV Gene

Proteins for CENPV Gene

  • Protein details for CENPV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Centromere protein V
    Protein Accession:
    Secondary Accessions:
    • B2RPK2
    • Q3L8N5
    • Q8NFH6

    Protein attributes for CENPV Gene

    275 amino acids
    Molecular mass:
    29946 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CENPV Gene


neXtProt entry for CENPV Gene

Proteomics data for CENPV Gene at MOPED

Post-translational modifications for CENPV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CENPV Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CENPV Gene

Domains & Families for CENPV Gene

Protein Domains for CENPV Gene


Suggested Antigen Peptide Sequences for CENPV Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Gfa family.
  • Belongs to the Gfa family.
genes like me logo Genes that share domains with CENPV: view

No data available for Gene Families for CENPV Gene

Function for CENPV Gene

Molecular function for CENPV Gene

UniProtKB/Swiss-Prot Function:
Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.
genes like me logo Genes that share phenotypes with CENPV: view

Animal Model Products

miRNA for CENPV Gene

miRTarBase miRNAs that target CENPV

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPV Gene

Localization for CENPV Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPV Gene

Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Enriched at the nuclear periphery and around the nucleolus (PubMed:12196509). In mitotic cells, localizes to kinetochores from prometaphase to metaphase (PubMed:18772885). At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis (PubMed:18772885).

Subcellular locations from

Jensen Localization Image for CENPV Gene COMPARTMENTS Subcellular localization image for CENPV gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
mitochondrion 3
extracellular 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CENPV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CENPV: view

Pathways & Interactions for CENPV Gene

SuperPathways for CENPV Gene

No Data Available

Gene Ontology (GO) - Biological Process for CENPV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031508 pericentric heterochromatin assembly IMP 18772885
GO:0032467 positive regulation of cytokinesis IMP 18772885
GO:0034508 centromere complex assembly IMP 18772885
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CENPV: view

No data available for Pathways by source and SIGNOR curated interactions for CENPV Gene

Drugs & Compounds for CENPV Gene

No Compound Related Data Available

Transcripts for CENPV Gene

mRNA/cDNA for CENPV Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CENPV Gene

Centromere protein V:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CENPV Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -

Relevant External Links for CENPV Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CENPV Gene

mRNA expression in normal human tissues for CENPV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CENPV Gene

This gene is overexpressed in Fetal Brain (14.5) and Testis (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPV Gene

SOURCE GeneReport for Unigene cluster for CENPV Gene Hs.433422

genes like me logo Genes that share expression patterns with CENPV: view

Protein tissue co-expression partners for CENPV Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CENPV Gene

Orthologs for CENPV Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CENPV Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CENPV 35
  • 85.93 (n)
  • 95.56 (a)
  • 65 (a)
(Canis familiaris)
Mammalia CENPV 35
  • 90.74 (n)
  • 95.68 (a)
  • 85 (a)
(Mus musculus)
Mammalia Cenpv 35
  • 78.57 (n)
  • 77.38 (a)
Cenpv 16
Cenpv 36
  • 74 (a)
(Pan troglodytes)
Mammalia CENPV 35
  • 99.63 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Cenpv 35
  • 70.04 (n)
  • 68.42 (a)
(Monodelphis domestica)
Mammalia CENPV 36
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia CENPV 36
  • 84 (a)
(Gallus gallus)
Aves CENPV 35
  • 76.51 (n)
  • 77.71 (a)
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpv 35
  • 73.9 (n)
  • 78.92 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5502 35
(Danio rerio)
Actinopterygii cenpv 35
  • 69.15 (n)
  • 75.37 (a)
cenpv 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6672 35
(Caenorhabditis elegans)
Secernentea CELE_F25B4.8 35
  • 55.46 (n)
  • 52.94 (a)
F25B4.8 36
  • 50 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G16940 35
  • 50.26 (n)
  • 46.92 (a)
(Oryza sativa)
Liliopsida Os09g0397700 35
  • 56.32 (n)
  • 52.59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8853 35
Species with no ortholog for CENPV:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CENPV Gene

Gene Tree for CENPV (if available)
Gene Tree for CENPV (if available)

Paralogs for CENPV Gene

Paralogs for CENPV Gene Pseudogenes for CENPV Gene

genes like me logo Genes that share paralogs with CENPV: view

Variants for CENPV Gene

Sequence variations from dbSNP and Humsavar for CENPV Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3095170 -- 16,354,782(-) gcggg(A/G)ggggg upstream-variant-2KB
rs3095172 -- 16,352,926(-) TTTCA(G/T)CTCTG intron-variant
rs3095173 -- 16,351,348(-) TTTAT(A/T)TATCG intron-variant
rs3095174 -- 16,351,180(-) GCCGA(C/G)GCGGG intron-variant
rs3095175 -- 16,350,399(-) GCCAC(C/T)GTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPV Gene

Variant ID Type Subtype PubMed ID
esv2715702 CNV Deletion 23290073
nsv827903 CNV Gain 20364138

Variation tolerance for CENPV Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CENPV Gene

Disorders for CENPV Gene

MalaCards: The human disease database

(3) MalaCards diseases for CENPV Gene - From: DISEASES

Disorder Aliases PubMed IDs
intracranial primitive neuroectodermal tumor
  • intracranial pnet
diffuse glomerulonephritis
  • glomerulonephritis diffuse
extraosseous ewing's sarcoma
  • extraosseous ewing sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search CENPV in MalaCards View complete list of genes associated with diseases

Relevant External Links for CENPV

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CENPV: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CENPV Gene

Publications for CENPV Gene

  1. CENP-V is required for centromere organization, chromosome alignment and cytokinesis. (PMID: 18772885) Tadeu A.M.B. … Earnshaw W.C. (EMBO J. 2008) 2 3 4 67
  2. Proteomic analysis of the mammalian nuclear pore complex. (PMID: 12196509) Cronshaw J.M. … Matunis M.J. (J. Cell Biol. 2002) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for CENPV Gene

Sources for CENPV Gene