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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CENPV Gene

protein-coding   GIFtS: 49
GCID: GC17M016245

centromere protein V

(Previous name: proline rich 6 )
(Previous symbol: PRR6)
 Explore 4 diseases affiliated with
CENPV via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CENPV    

Aliases
for CENPV gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Centromere Protein V1 2     Nuclear Protein P302 3
CENP-V1 2 3     Proline-Rich Protein 62 3
PRR61 2 3     3110013H01Rik2
P305     P305
Proline Rich 61 2     

External Ids:    HGNC: 299201   Entrez Gene: 2011612   Ensembl: ENSG000001665827   OMIM: 6081395   UniProtKB: Q7Z7K63   

Export aliases for CENPV gene to outside databases

Previous GC identifer: GC17M016189


Summaries
for CENPV gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CENPV_HUMAN, Q7Z7K6
Function: Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere
formation and organization, chromosome alignment and cytokinesis




Genomic Views
for CENPV gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CENPV gene promoter:
         CREB   p300   deltaCREB   Nkx2-5   Nkx5-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CENPV

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPV


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

CENPV Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPV gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M016245:  view genomic region     (about GC identifiers)

Start:
 16,245,848 bp from pter      End:
 16,256,970 bp from pter
Size:
 11,123 bases      Orientation:
 minus strand

Proteins
for CENPV gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CENPV_HUMAN, Q7Z7K6 (See protein sequence)
Recommended Name: Centromere protein V  
Size: 275 amino acids; 29946 Da
Subcellular location: Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Enriched at
the nuclear periphery and around the nucleolus. In mitotic cells, localizes to kinetochores from prometaphase to
metaphase. At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis
Secondary accessions: B2RPK2 Q3L8N5 Q8NFH6
Alternative splicing: 3 isoforms:  Q7Z7K6-1   Q7Z7K6-2   Q7Z7K6-3   

Explore the universe of human proteins at neXtProt for CENPV: NX_Q7Z7K6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q7Z7K6

    • CENPV Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_859067.2  
    ENSEMBL proteins: 
     ENSP00000462377   ENSP00000299736   ENSP00000468338  

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    Uscn Proteins for CENPV

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA18772885
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    CENPV for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CENPV

    Protein Domains /
    Families
    for CENPV gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CENPV for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011057 Mss4-like
     IPR006913 GFA/CENP-V

    Graphical View of Domain Structure for InterPro Entry Q7Z7K6

    ProtoNet protein and cluster: Q7Z7K6

    UniProtKB/Swiss-Prot: CENPV_HUMAN, Q7Z7K6
    Similarity: Belongs to the gfa family


    Function
    for CENPV gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CENPV_HUMAN, Q7Z7K6
    Function: Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere
    formation and organization, chromosome alignment and cytokinesis

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0016846carbon-sulfur lyase activity IEA--


    CENPV for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CENPV:
     Decreased TP53 protein express  Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for CENPV gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CENPV

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for CENPV (Q7Z7K62, 3 ENSP000002997364) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062412, 3, ENSP000003576564MINT-8109241 I2D: score=1 STRING: ENSP00000357656
    LYNP079482, 3MINT-8109226 I2D: score=2 
    SRCP129312, 3, ENSP000003509414MINT-8109211 I2D: score=1 STRING: ENSP00000350941
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001667ameboidal cell migration IDA19930468
    GO:0007067mitosis IEA--
    GO:0031508centromeric heterochromatin assembly IMP18772885
    GO:0032467positive regulation of cytokinesis IMP18772885
    GO:0033044regulation of chromosome organization IMP18772885


    CENPV for ontologies           About GeneDecksing



    Drugs & Compounds
    for CENPV gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CENPV
    Search CenterWatch for drugs/clinical trials and news about CENPV 

    Transcripts
    for CENPV gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CENPV gene: 
    NM_181716.2  

    Unigene Cluster for CENPV:

    Centromere protein V
    Hs.433422  [show with all ESTs]
    Unigene Representative Sequence: BQ052702
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472570 ENST00000476243 ENST00000299736(uc002gpw.3) ENST00000482983
    ENST00000582062 ENST00000584214

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    hsa-miR-22 hsa-miR-377 hsa-miR-558
    SwitchGear 3'UTR luciferase reporter plasmid: CENPV 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF514992.1 AY382899.1 BC052604.1 BC137486.1 BC137487.1 

    8 DOTS entries:

    DT.447635  DT.102829193  DT.102829194  DT.100780498  DT.95155203  DT.87003668  DT.100780497  DT.95372730 

    2 AceView cDNA sequences:

    BV185418 BV185419 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CENPV    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:              -     -                           
    SP2:                                                
    SP3:                                                
    SP4:                                                


    ECgene alternative splicing isoforms for CENPV

    Expression
    for CENPV gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CENPV expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTAAAGAGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CENPV expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CENPV Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CENPV

    SOURCE GeneReport for Unigene cluster: Hs.433422
        SABiosciences Custom PCR Arrays for CENPV
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    In Situ
    Assay Products:     
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    Orthologs
    for CENPV gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CENPV gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cenpv1 , 5 centromere protein V1, 5 78.84(n)1
    79.37(a)1    		   11 (38.43 cM)5
    731391  NM_028448.11  NP_082724.11 
     625249465 
    chicken
    (Gallus gallus)    		 Aves CENPV1 centromere protein V 75.74(n)
    76.92(a)    		   417601  XM_415846.3  XP_415846.2 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.55022 Xenopus laevis transcribed sequences 78.95(n)    48029780 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003340101 novel protein similar to vertebrate proline rich 6 more 69.15(n)
    75.37(a)    		   100334010  XM_002662055.1  XP_002662101.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea CELE_F25B4.81 Protein F25B4.8 55.46(n)
    52.94(a)    		   184918  NM_171459.2  NP_741540.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G169401 carbon-sulfur lyase 50.26(n)
    46.92(a)    		   831557  NM_121700.4  NP_197196.1 
    rice
    (Oryza sativa)    		 Liliopsida Os09g03977001 hypothetical protein 56.32(n)
    52.59(a)    		   4346983  NM_001069641.1  NP_001063106.1 


    ENSEMBL Gene Tree for CENPV (if available)
    TreeFam Gene Tree for CENPV (if available) 

    Paralogs
    for CENPV gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CENPV gene

    CENPV for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CENPV
    PGOHUM00000241297 PGOHUM00000241298 PGOHUM00000241757 PGOHUM00000241759


    Genomic Variants
    for CENPV gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/209 NCBI SNPs in CENPV are shown (see all 209)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs762271361,2
    		C--16245406(-) AAATAT/CAAAAA 1 -- ds50011Minor allele frequency- C:0.00NA 2
    rs126037121,2
    		C,F,A,H,--16245481(+) CACCCA/GCCTCA 1 -- ds50015Minor allele frequency- G:0.33NA WA 12
    rs1167296151,2
    		F,--16245659(+) GCAGTA/GGCACG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1862738601,2
    		--16245712(+) CCTCCA/GGAGTA 1 -- ds50010--------
    rs31125241,2
    		C,F,A,H,--16245778(+) GAGTAC/TATATC 1 -- ds500122Minor allele frequency- T:0.44NS EA NA WA CSA 2336
    rs1502598761,2
    		--16245794(+) TTAATC/TGACTG 1 -- ds50010--------
    rs1915668381,2
    		--16245910(+) AGAGAA/CGGATG 1 -- ut310--------
    rs74771,2
    		C,F,A,H,--16246016(-) TCCGTT/GGACTA 1 -- ut31 ese327Minor allele frequency- G:0.26MN NS EA NA CSA WA 2952
    rs1160705401,2
    		--16246058(+) CACCAC/TCGAGG 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1143094591,2
    		C,--16246066(+) AGGCAC/TGGCAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CENPV (16245848 - 16256970 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CENPV: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CENPV
    DNA2.0 Custom Variant and Variant Library Synthesis for CENPV

    Disorders / Diseases
    for CENPV gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CENPV for disorders           About GeneDecksing

    OMIM gene information: 608139    OMIM disorders: --

    4 diseases for CENPV:    About MalaCards
    ectomesenchymoma    histoplasmosis    lyme disease    toxoplasmosis

    3 diseases from the University of Copenhagen DISEASES database for CENPV:
    Sarcoma     Leukemia     Intracranial primitive neuroectodermal tumor

    Export disorders for CENPV gene to outside databases

    Publications
    for CENPV gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CENPV gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CENPV)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CENP-V is required for centromere organization, chromosome alignment and cytokinesis. (PubMed id 18772885)1, 2, 3 Tadeu A.M.B....Earnshaw W.C. (2008)
    2. Proteomic analysis of the mammalian nuclear pore complex. (PubMed id 12196509)1, 2, 3 Cronshaw J.M.... Matunis M.J. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    6. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    7. Identification of CENP-V as a novel microtubule-assoc iating molecule that activates Src family kinases through SH3 domain interactio n. (PubMed id 19930468)1 Honda Z....Honda H. (2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. (PubMed id 17000644)1 Vertegaal A.C....Lamond A.I. (2006)

    External Searches for CENPV gene

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    Genome Databases showing CENPV gene

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    Entrez Gene: 201161 HGNC: 29920 AceView: p30 Ensembl:ENSG00000166582 euGenes: HUgn201161
    ECgene: CENPV H-InvDB: CENPV

    Other Databases showing CENPV gene

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    Specialized Databases showing CENPV gene

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    PharmGKB entry for CENPV Pharmacogenomics, SNPs, Pathways

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