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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CENPV Gene

protein-coding   GIFtS: 50
GCID: GC17M016245

Centromere Protein V

(Previous name: proline rich 6)
(Previous symbol: PRR6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Centromere Protein V1 2     CENP-V2 3
PRR61 2 3     3110013H01Rik2
Proline Rich 61 2     p302
Nuclear Protein P302 3     P305
Proline-Rich Protein 62 3     

External Ids:    HGNC: 299201   Entrez Gene: 2011612   Ensembl: ENSG000001665827   OMIM: 6081395   UniProtKB: Q7Z7K63   

Export aliases for CENPV gene to outside databases

Previous GC identifer: GC17M016189


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CENPV Gene: 
CENPV (centromere protein V) is a protein-coding gene. Diseases associated with CENPV include ectomesenchymoma, and intracranial primitive neuroectodermal tumor. GO annotations related to this gene include carbon-sulfur lyase activity and molecular_function.

UniProtKB/Swiss-Prot: CENPV_HUMAN, Q7Z7K6
Function: Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere
formation and organization, chromosome alignment and cytokinesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CENPV gene promoter:
         CREB   p300   deltaCREB   Nkx2-5   Nkx5-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CENPV

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPV


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

CENPV Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPV gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M016245:  view genomic region     (about GC identifiers)

Start:
16,245,848 bp from pter      End:
16,256,970 bp from pter
Size:
11,123 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CENPV_HUMAN, Q7Z7K6 (See protein sequence)
Recommended Name: Centromere protein V  
Size: 275 amino acids; 29946 Da
Subcellular location: Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle.
Note=Enriched at the nuclear periphery and around the nucleolus. In mitotic cells, localizes to kinetochores from
prometaphase to metaphase. At anaphase onset, transfers to the spindle midzone and then to the mid-body in
telophase and cytokinesis
Secondary accessions: B2RPK2 Q3L8N5 Q8NFH6
Alternative splicing: 3 isoforms:  Q7Z7K6-1   Q7Z7K6-2   Q7Z7K6-3   

Explore the universe of human proteins at neXtProt for CENPV: NX_Q7Z7K6

Explore proteomics data for CENPV at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z7K6

  • CENPV Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CENPV Protein Expression
    REFSEQ proteins: NP_859067.2  
    ENSEMBL proteins: 
     ENSP00000462377   ENSP00000299736   ENSP00000468338  

    Human Recombinant Protein Products for CENPV: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CENPV 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA18772885
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    CENPV for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR011057 Mss4-like
     IPR006913 GFA/CENP-V

    Graphical View of Domain Structure for InterPro Entry Q7Z7K6

    ProtoNet protein and cluster: Q7Z7K6

    UniProtKB/Swiss-Prot: CENPV_HUMAN, Q7Z7K6
    Similarity: Belongs to the gfa family


    CENPV for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPV_HUMAN, Q7Z7K6
    Function: Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere
    formation and organization, chromosome alignment and cytokinesis

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0016846carbon-sulfur lyase activity IEA--
         
    CENPV for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CENPV:
     Decreased TP53 protein express  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CENPV 
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CENPV:
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    SwitchGear 3'UTR luciferase reporter plasmidCENPV 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CENPV

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for CENPV (Q7Z7K62, 3 ENSP000002997364) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FYNP062412, 3, ENSP000003576564MINT-8109241 I2D: score=1 STRING: ENSP00000357656
    LYNP079482, 3MINT-8109226 I2D: score=2 
    SRCP129312, 3, ENSP000003509414MINT-8109211 I2D: score=1 STRING: ENSP00000350941
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001667ameboidal cell migration IDA19930468
    GO:0007067mitosis IEA--
    GO:0008152metabolic process ----
    GO:0031508centromeric heterochromatin assembly IMP18772885
    GO:0032467positive regulation of cytokinesis IMP18772885

    CENPV for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CENPV

    Search CenterWatch for drugs/clinical trials and news about CENPV

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CENPV gene: 
    NM_181716.2  

    Unigene Cluster for CENPV:

    Centromere protein V
    Hs.433422  [show with all ESTs]
    Unigene Representative Sequence: BQ052702
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000472570 ENST00000476243 ENST00000299736(uc002gpw.3) ENST00000482983
    ENST00000582062 ENST00000584214
    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CENPV:
    hsa-miR-22 hsa-miR-377 hsa-miR-558
    SwitchGear 3'UTR luciferase reporter plasmidCENPV 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Additional mRNA sequence: 

    AF514992.1 AY382899.1 BC052604.1 BC137486.1 BC137487.1 

    8 DOTS entries:

    DT.447635  DT.102829193  DT.102829194  DT.95155203  DT.100780498  DT.100780497  DT.87003668  DT.95372730 

    2 AceView cDNA sequences:

    BV185419 BV185418 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CENPV    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:              -     -                           
    SP2:                                                
    SP3:                                                
    SP4:                                                


    ECgene alternative splicing isoforms for CENPV

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CENPV expression in normal human tissues (normalized intensities)      CENPV embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTAAAGAGT
    CENPV Expression
    About this image


    CENPV expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood-derived endothelial progenitor cells
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Human Cerebellar Astrocytes   
     
     Umbilical Cord (Extraembryonic Tissues)
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Sox17-GFP genetically modified stem cells
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells I Spleen

    See CENPV Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CENPV

    SOURCE GeneReport for Unigene cluster: Hs.433422
        SABiosciences Custom PCR Arrays for CENPV
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPV

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CENPV gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenpv1 , 5 centromere protein V1, 5 78.84(n)1
    79.37(a)1
      11 (38.43 cM)5
    731391  NM_028448.11  NP_082724.11 
     625249465 
    chicken
    (Gallus gallus)
    Aves CENPV1 centromere protein V 75.74(n)
    76.92(a)
      417601  XM_415846.3  XP_415846.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.55022 Xenopus laevis transcribed sequences 78.95(n)    48029780 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003340101 novel protein similar to vertebrate proline rich 6 more 69.15(n)
    75.37(a)
      100334010  XM_002662055.1  XP_002662101.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_F25B4.81 Protein F25B4.8 55.46(n)
    52.94(a)
      184918  NM_171459.2  NP_741540.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G169401 carbon-sulfur lyase 50.26(n)
    46.92(a)
      831557  NM_121700.4  NP_197196.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g03977001 hypothetical protein 56.32(n)
    52.59(a)
      4346983  NM_001069641.1  NP_001063106.1 


    ENSEMBL Gene Tree for CENPV (if available)
    TreeFam Gene Tree for CENPV (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CENPV gene

    CENPV for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for CENPV
    PGOHUM00000241297 PGOHUM00000241298 PGOHUM00000241757 PGOHUM00000241759


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/251 SNPs in CENPV are shown (see all 251)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs126037121,2
    C,F,A,H--16245481(+) CACCCA/GCCTCA 1 -- ds50015Minor allele frequency- G:0.33NA WA 12
    rs1167296151,2
    C,F--16245659(+) GCAGTA/GGCACG 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1862738601,2
    --16245712(+) CCTCCA/GGAGTA 1 -- ds50010--------
    rs31125241,2
    C,F,A,H--16245778(+) GAGTAC/TATATC 1 -- ds500122Minor allele frequency- T:0.44NS EA NA WA CSA 2336
    rs1502598761,2
    --16245794(+) TTAATC/TGACTG 1 -- ds50010--------
    rs1915668381,2
    --16245910(+) AGAGAA/CGGATG 1 -- ut310--------
    rs74771,2
    C,F,A,H--16246016(-) TCCGTT/GGACTA 1 -- ut31 ese327Minor allele frequency- G:0.26MN NS EA NA CSA WA 2952
    rs1160705401,2
    F--16246058(+) CACCAC/TCGAGG 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1143094591,2
    C--16246066(+) AGGCAC/TGGCAG 1 -- ut310--------
    rs1417302891,2
    C--16246120(+) CAGGAA/GAGGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CENPV (16245848 - 16256970 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CENPV:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715702CNV Deletion23290073
    nsv827903CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CENPV
    DNA2.0 Custom Variant and Variant Library Synthesis for CENPV

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608139    OMIM disorders: --

    7 diseases for CENPV:    About MalaCards
    ectomesenchymoma    intracranial primitive neuroectodermal tumor    histoplasmosis    lyme disease
    toxoplasmosis    primitive neuroectodermal tumor    sarcoma

    3 diseases from the University of Copenhagen DISEASES database for CENPV:
    Sarcoma     Leukemia     Intracranial primitive neuroectodermal tumor

    CENPV for disorders           About GeneDecksing


    Export disorders for CENPV gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CENPV gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with CENPV)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CENP-V is required for centromere organization, chromosome alignment and cytokinesis. (PubMed id 18772885)1, 2, 3 Tadeu A.M.B....Earnshaw W.C. (2008)
    2. Proteomic analysis of the mammalian nuclear pore complex. (PubMed id 12196509)1, 2, 3 Cronshaw J.M.... Matunis M.J. (2002)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Age of onset of amyotrophic lateral sclerosis is modul ated by a locus on 1p34.1. (PubMed id 22959728)1  ....Zheng J.G. (2013)
    5. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    6. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    8. Identification of CENP-V as a novel microtubule-assoc iating molecule that activates Src family kinases through SH3 domain interactio n. (PubMed id 19930468)1 Honda Z....Honda H. (2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 201161 HGNC: 29920 AceView: p30 Ensembl:ENSG00000166582 euGenes: HUgn201161
    ECgene: CENPV H-InvDB: CENPV

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for CENPV Pharmacogenomics, SNPs, Pathways

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