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Aliases for CENPV Gene

Aliases for CENPV Gene

  • Centromere Protein V 2 3 5
  • Proline-Rich Protein 6 3 4
  • Nuclear Protein P30 3 4
  • Proline Rich 6 2 3
  • CENP-V 3 4
  • PRR6 3 4
  • 3110013H01Rik 3
  • P30 3

External Ids for CENPV Gene

Previous HGNC Symbols for CENPV Gene

  • PRR6

Previous GeneCards Identifiers for CENPV Gene

  • GC17M016189
  • GC17M016245

Summaries for CENPV Gene

GeneCards Summary for CENPV Gene

CENPV (Centromere Protein V) is a Protein Coding gene. Diseases associated with CENPV include Intracranial Primitive Neuroectodermal Tumor and Diffuse Glomerulonephritis. GO annotations related to this gene include carbon-sulfur lyase activity. An important paralog of this gene is CENPVL3.

UniProtKB/Swiss-Prot for CENPV Gene

  • Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.

Additional gene information for CENPV Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPV Gene

Genomics for CENPV Gene

Regulatory Elements for CENPV Gene

Enhancers for CENPV Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H016312 1.3 ENCODE dbSUPER 21.7 +39.9 39941 1.6 PKNOX1 ATF1 FOXA2 ARNT ARID4B FEZF1 DMAP1 YY1 TCF12 GATA2 ZSWIM7 CENPV MIR1288 LRRC75A-AS1 LRRC75A TTC19 GC17M016316
GH17H016328 1.1 Ensembl ENCODE 25 +24.0 23972 1.4 TBP CTCF KLF17 EBF1 POLR2A SCRT2 FOS ZNF548 IKZF2 CHD2 ENSG00000266538 CENPV PIGL LOC644422 TVP23C NCOR1 ACTG1P24 PPIAP53 TTC19 GC17M016323
GH17H016397 1.2 Ensembl ENCODE 13.7 -44.9 -44949 1.8 ATF1 FOXA2 ARNT YY1 TCF12 GATA2 FOS ATF7 NCOA1 REST CENPV LRRC75A-AS1 LRRC75A TRPV2 TNFRSF13B GC17P016393
GH17H016322 0.4 ENCODE 25.2 +30.7 30665 1.8 FOS MAFK CENPV GC17M016323 GC17M016316
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CENPV on UCSC Golden Path with GeneCards custom track

Promoters for CENPV Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000091753 756 2201 ARID4B SIN3A FEZF1 DMAP1 GLI4 BRCA1 YY1 ZNF766 GLIS2 ZNF143

Genomic Locations for CENPV Gene

Genomic Locations for CENPV Gene
11,123 bases
Minus strand

Genomic View for CENPV Gene

Genes around CENPV on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPV Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPV Gene

Proteins for CENPV Gene

  • Protein details for CENPV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Centromere protein V
    Protein Accession:
    Secondary Accessions:
    • B2RPK2
    • Q3L8N5
    • Q8NFH6

    Protein attributes for CENPV Gene

    275 amino acids
    Molecular mass:
    29946 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CENPV Gene


neXtProt entry for CENPV Gene

Post-translational modifications for CENPV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CENPV Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CENPV Gene

Domains & Families for CENPV Gene

Gene Families for CENPV Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CENPV Gene


Suggested Antigen Peptide Sequences for CENPV Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Gfa family.
  • Belongs to the Gfa family.
genes like me logo Genes that share domains with CENPV: view

Function for CENPV Gene

Molecular function for CENPV Gene

UniProtKB/Swiss-Prot Function:
Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.

Phenotypes From GWAS Catalog for CENPV Gene

Gene Ontology (GO) - Molecular Function for CENPV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016846 carbon-sulfur lyase activity IEA --
genes like me logo Genes that share ontologies with CENPV: view
genes like me logo Genes that share phenotypes with CENPV: view

miRNA for CENPV Gene

miRTarBase miRNAs that target CENPV

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPV Gene

Localization for CENPV Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPV Gene

Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Enriched at the nuclear periphery and around the nucleolus (PubMed:12196509). In mitotic cells, localizes to kinetochores from prometaphase to metaphase (PubMed:18772885). At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis (PubMed:18772885).

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPV gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 3
extracellular 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CENPV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA,IEA 18772885
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA,IEA 12196509
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with CENPV: view

Pathways & Interactions for CENPV Gene

SuperPathways for CENPV Gene

No Data Available

Gene Ontology (GO) - Biological Process for CENPV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001667 ameboidal-type cell migration IDA 19930468
GO:0007049 cell cycle IEA --
GO:0008152 metabolic process IEA --
GO:0031508 pericentric heterochromatin assembly IMP 18772885
GO:0032467 positive regulation of cytokinesis IMP 18772885
genes like me logo Genes that share ontologies with CENPV: view

No data available for Pathways by source and SIGNOR curated interactions for CENPV Gene

Drugs & Compounds for CENPV Gene

No Compound Related Data Available

Transcripts for CENPV Gene

Unigene Clusters for CENPV Gene

Centromere protein V:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CENPV Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -

Relevant External Links for CENPV Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CENPV Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CENPV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CENPV Gene

This gene is overexpressed in Fetal Brain (14.5) and Testis (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CENPV Gene

Protein tissue co-expression partners for CENPV Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CENPV Gene:


SOURCE GeneReport for Unigene cluster for CENPV Gene:


Evidence on tissue expression from TISSUES for CENPV Gene

  • Blood(4.5)
  • Liver(4.3)
  • Nervous system(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with CENPV: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPV Gene

Orthologs for CENPV Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CENPV Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CENPV 33 34
  • 99.63 (n)
(Canis familiaris)
Mammalia CENPV 33 34
  • 90.74 (n)
(Bos Taurus)
Mammalia CENPV 33 34
  • 85.93 (n)
(Ornithorhynchus anatinus)
Mammalia CENPV 34
  • 84 (a)
(Mus musculus)
Mammalia Cenpv 33 16 34
  • 78.57 (n)
(Rattus norvegicus)
Mammalia Cenpv 33
  • 70.04 (n)
(Monodelphis domestica)
Mammalia CENPV 34
  • 62 (a)
(Gallus gallus)
Aves CENPV 33 34
  • 76.51 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpv 33
  • 73.9 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5502 33
(Danio rerio)
Actinopterygii cenpv 33 34
  • 69.15 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6672 33
(Caenorhabditis elegans)
Secernentea CELE_F25B4.8 33
  • 55.46 (n)
F25B4.8 34
  • 50 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G16940 33
  • 50.26 (n)
(Oryza sativa)
Liliopsida Os09g0397700 33
  • 56.32 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8853 33
Species where no ortholog for CENPV was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CENPV Gene

Gene Tree for CENPV (if available)
Gene Tree for CENPV (if available)

Paralogs for CENPV Gene

Paralogs for CENPV Gene

genes like me logo Genes that share paralogs with CENPV: view

Variants for CENPV Gene

Sequence variations from dbSNP and Humsavar for CENPV Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000119487 -- 16,351,874(+) TCTTC(A/G)TATTC intron-variant, downstream-variant-500B
rs1000255906 -- 16,351,627(+) ACACA(A/G)TATTT intron-variant, utr-variant-3-prime
rs1000340783 -- 16,343,552(+) GTCTC(A/G)AACTC intron-variant
rs1000341057 -- 16,345,396(+) AAACC(C/G)TGTTT intron-variant
rs1000371755 -- 16,343,325(+) TTAGA(C/T)AGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPV Gene

Variant ID Type Subtype PubMed ID
nsv827903 CNV gain 20364138
nsv1144792 CNV deletion 24896259
nsv1063764 CNV loss 25217958
esv2715702 CNV deletion 23290073

Variation tolerance for CENPV Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CENPV Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPV Gene

Disorders for CENPV Gene

MalaCards: The human disease database

(4) MalaCards diseases for CENPV Gene - From: DISEASES

Disorder Aliases PubMed IDs
intracranial primitive neuroectodermal tumor
  • intracranial pnet
diffuse glomerulonephritis
  • glomerulonephritis diffuse
bone ewing's sarcoma
  • bone ewing sarcoma
extraosseous ewing's sarcoma
  • extraosseous ewing sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search CENPV in MalaCards View complete list of genes associated with diseases

Relevant External Links for CENPV

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CENPV: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CENPV Gene

Publications for CENPV Gene

  1. CENP-V is required for centromere organization, chromosome alignment and cytokinesis. (PMID: 18772885) Tadeu AM … Earnshaw WC (The EMBO journal 2008) 2 3 4 60
  2. Proteomic analysis of the mammalian nuclear pore complex. (PMID: 12196509) Cronshaw JM … Matunis MJ (The Journal of cell biology 2002) 2 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping. (PMID: 28611094) Lempiäinen JK … Palvimo JJ (Molecular & cellular proteomics : MCP 2017) 3 60

Products for CENPV Gene

Sources for CENPV Gene

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