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Aliases for CENPV Gene

Aliases for CENPV Gene

  • Centromere Protein V 2 3
  • Proline-Rich Protein 6 3 4
  • Nuclear Protein P30 3 4
  • Proline Rich 6 2 3
  • CENP-V 3 4
  • PRR6 3 4
  • P30 3 6
  • 3110013H01Rik 3

External Ids for CENPV Gene

Previous HGNC Symbols for CENPV Gene

  • PRR6

Previous GeneCards Identifiers for CENPV Gene

  • GC17M016189
  • GC17M016245

Summaries for CENPV Gene

GeneCards Summary for CENPV Gene

CENPV (Centromere Protein V) is a Protein Coding gene. Diseases associated with CENPV include intracranial primitive neuroectodermal tumor. GO annotations related to this gene include carbon-sulfur lyase activity.

UniProtKB/Swiss-Prot for CENPV Gene

  • Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPV Gene

Genomics for CENPV Gene

Regulatory Elements for CENPV Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CENPV Gene

Start:
16,342,534 bp from pter
End:
16,353,656 bp from pter
Size:
11,123 bases
Orientation:
Minus strand

Genomic View for CENPV Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CENPV Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPV Gene

Proteins for CENPV Gene

  • Protein details for CENPV Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7K6-CENPV_HUMAN
    Recommended name:
    Centromere protein V
    Protein Accession:
    Q7Z7K6
    Secondary Accessions:
    • B2RPK2
    • Q3L8N5
    • Q8NFH6

    Protein attributes for CENPV Gene

    Size:
    275 amino acids
    Molecular mass:
    29946 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CENPV Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPV Gene

Proteomics data for CENPV Gene at MOPED

Post-translational modifications for CENPV Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CENPV Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CENPV Gene

Domains for CENPV Gene

Protein Domains for CENPV Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPV Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7K6

UniProtKB/Swiss-Prot:

CENPV_HUMAN :
  • Q7Z7K6
Family:
  • Belongs to the Gfa family.
genes like me logo Genes that share domains with CENPV: view

No data available for Gene Families for CENPV Gene

Function for CENPV Gene

Molecular function for CENPV Gene

UniProtKB/Swiss-Prot Function: Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis.

Gene Ontology (GO) - Molecular Function for CENPV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016846 carbon-sulfur lyase activity IEA --
genes like me logo Genes that share ontologies with CENPV: view
genes like me logo Genes that share phenotypes with CENPV: view

Animal Model Products

CRISPR Products

miRNA for CENPV Gene

miRTarBase miRNAs that target CENPV

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CENPV

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CENPV Gene

Localization for CENPV Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPV Gene

Chromosome, centromere, kinetochore. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Enriched at the nuclear periphery and around the nucleolus. In mitotic cells, localizes to kinetochores from prometaphase to metaphase. At anaphase onset, transfers to the spindle midzone and then to the mid-body in telophase and cytokinesis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPV Gene COMPARTMENTS Subcellular localization image for CENPV gene
Compartment Confidence
cytoskeleton 5
nucleus 5
mitochondrion 3
extracellular 2
plasma membrane 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CENPV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 18772885
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA 12196509
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with CENPV: view

Pathways for CENPV Gene

SuperPathways for CENPV Gene

No Data Available

Gene Ontology (GO) - Biological Process for CENPV Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001667 ameboidal-type cell migration IDA 19930468
GO:0007067 mitotic nuclear division IEA --
GO:0008152 metabolic process IEA --
GO:0031508 pericentric heterochromatin assembly IMP 18772885
GO:0032467 positive regulation of cytokinesis IMP 18772885
genes like me logo Genes that share ontologies with CENPV: view

No data available for Pathways by source for CENPV Gene

Transcripts for CENPV Gene

mRNA/cDNA for CENPV Gene

(5) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CENPV Gene

Centromere protein V:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CENPV

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CENPV Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for CENPV Gene

GeneLoc Exon Structure for
CENPV
ECgene alternative splicing isoforms for
CENPV

Expression for CENPV Gene

mRNA expression in normal human tissues for CENPV Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPV Gene

SOURCE GeneReport for Unigene cluster for CENPV Gene Hs.433422

genes like me logo Genes that share expressions with CENPV: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CENPV Gene

Orthologs for CENPV Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CENPV Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPV 35
  • 99.63 (n)
  • 100 (a)
CENPV 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CENPV 35
  • 85.93 (n)
  • 95.56 (a)
CENPV 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CENPV 35
  • 90.74 (n)
  • 95.68 (a)
CENPV 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cenpv 35
  • 78.57 (n)
  • 77.38 (a)
Cenpv 16
Cenpv 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPV 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPV 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpv 35
  • 70.04 (n)
  • 68.42 (a)
chicken
(Gallus gallus)
Aves CENPV 35
  • 76.51 (n)
  • 77.71 (a)
CENPV 36
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5502 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpv 35
  • 73.9 (n)
  • 78.92 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6672 35
zebrafish
(Danio rerio)
Actinopterygii cenpv 35
  • 69.15 (n)
  • 75.37 (a)
cenpv 36
  • 69 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F25B4.8 35
  • 55.46 (n)
  • 52.94 (a)
F25B4.8 36
  • 50 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G16940 35
  • 50.26 (n)
  • 46.92 (a)
rice
(Oryza sativa)
Liliopsida Os09g0397700 35
  • 56.32 (n)
  • 52.59 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8853 35
Species with no ortholog for CENPV:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CENPV Gene

ENSEMBL:
Gene Tree for CENPV (if available)
TreeFam:
Gene Tree for CENPV (if available)

Paralogs for CENPV Gene

Pseudogenes.org Pseudogenes for CENPV Gene

genes like me logo Genes that share paralogs with CENPV: view

No data available for Paralogs for CENPV Gene

Variants for CENPV Gene

Sequence variations from dbSNP and Humsavar for CENPV Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs3095170 -- 16,354,782(-) gcggg(A/G)ggggg upstream-variant-2KB
rs3095172 -- 16,352,926(-) TTTCA(G/T)CTCTG intron-variant
rs3095173 -- 16,351,348(-) TTTAT(A/T)TATCG intron-variant
rs3095174 -- 16,351,180(-) GCCGA(C/G)GCGGG intron-variant
rs3095175 -- 16,350,399(-) GCCAC(C/T)GTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPV Gene

Variant ID Type Subtype PubMed ID
esv2715702 CNV Deletion 23290073
nsv827903 CNV Gain 20364138

Relevant External Links for CENPV Gene

HapMap Linkage Disequilibrium report
CENPV

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPV Gene

Disorders for CENPV Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CENPV Gene including...

Search for CENPV Gene in MalaCards »

(3) University of Copenhagen DISEASES for CENPV Gene

genes like me logo Genes that share disorders with CENPV: view

No data available for UniProtKB/Swiss-Prot for CENPV Gene

Publications for CENPV Gene

  1. CENP-V is required for centromere organization, chromosome alignment and cytokinesis. (PMID: 18772885) Tadeu A.M.B. … Earnshaw W.C. (EMBO J. 2008) 2 3 4
  2. Proteomic analysis of the mammalian nuclear pore complex. (PMID: 12196509) Cronshaw J.M. … Matunis M.J. (J. Cell Biol. 2002) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. (PMID: 17000644) Vertegaal A.C. … Lamond A.I. (Mol. Cell Proteomics 2006) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for CENPV Gene

Sources for CENPV Gene

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