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Aliases for CENPU Gene

Aliases for CENPU Gene

  • Centromere Protein U 2 3 5
  • Polo-Box-Interacting Protein 1 2 3 4
  • Interphase Centromere Complex Protein 24 3 4
  • Centromere Protein Of 50 KDa 3 4
  • MLF1 Interacting Protein 2 3
  • MLF1IP 3 4
  • KLIP1 3 4
  • PBIP1 3 4
  • KSHV Latent Nuclear Antigen Interacting Protein 1 3
  • KSHV Latent Nuclear Antigen-Interacting Protein 1 4
  • MLF1-Interacting Protein 4
  • CENPU50 3
  • CENP-50 4
  • CENP50 3
  • CENP-U 4
  • ICEN24 4

External Ids for CENPU Gene

Previous HGNC Symbols for CENPU Gene

  • MLF1IP

Previous GeneCards Identifiers for CENPU Gene

  • GC04M185616

Summaries for CENPU Gene

Entrez Gene Summary for CENPU Gene

  • The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CENPU Gene

CENPU (Centromere Protein U) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CENPU Gene

  • Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.

Gene Wiki entry for CENPU Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPU Gene

Genomics for CENPU Gene

Regulatory Elements for CENPU Gene

Enhancers for CENPU Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F184731 1.2 ENCODE 52.5 +0.8 766 3.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC CENPU PRIMPOL CFAP97 UFSP2 GC04P184696
GH04F184687 0.9 Ensembl ENCODE 55.5 +45.7 45725 2.2 IRF2 JUN BHLHE40 CEBPB SIN3A ZIC2 NFIL3 JUND IRF1 FOS CENPU PRIMPOL CASP3 GC04P184696
GH04F184653 1.1 Ensembl ENCODE 31.1 +80.2 80165 1.8 ELF3 HDAC1 CBX3 PKNOX1 ZNF366 ZNF263 ZBTB11 ELF1 ZEB2 POLR2H CENPU PRIMPOL GC04P184696
GH04F184644 1.3 Ensembl ENCODE 25.1 +86.4 86367 6.6 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF263 SP3 SP5 JUNB MXD4 CENPU ACSL1 IRF2 PRIMPOL CASP3 LVCAT8
GH04F184727 0.8 ENCODE 38.7 +5.0 5043 2.5 ELF3 SOX13 JUN CEBPG RAD21 RARA GATA3 GATA4 RERE NR2F6 CENPU GC04P184696
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CENPU on UCSC Golden Path with GeneCards custom track

Promoters for CENPU Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001255750 333 2401 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC

Genomic Location for CENPU Gene

Chromosome:
4
Start:
184,694,065 bp from pter
End:
184,734,133 bp from pter
Size:
40,069 bases
Orientation:
Minus strand

Genomic View for CENPU Gene

Genes around CENPU on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPU Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPU Gene

Proteins for CENPU Gene

  • Protein details for CENPU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q71F23-CENPU_HUMAN
    Recommended name:
    Centromere protein U
    Protein Accession:
    Q71F23
    Secondary Accessions:
    • A2RRD9
    • Q09GN2
    • Q32Q71
    • Q9H5G1

    Protein attributes for CENPU Gene

    Size:
    418 amino acids
    Molecular mass:
    47522 Da
    Quaternary structure:
    • Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts with the N-terminal domain of Kaposis sarcoma-associated herpesvirus latent nuclear antigen (LNA). Interacts with MLF1. Interacts with PLK1.

    Alternative splice isoforms for CENPU Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPU Gene

Post-translational modifications for CENPU Gene

  • Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1.
  • Ubiquitination at Lys 260 and Lys 393
  • Modification sites at PhosphoSitePlus

Other Protein References for CENPU Gene

No data available for DME Specific Peptides for CENPU Gene

Domains & Families for CENPU Gene

Protein Domains for CENPU Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPU Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CENPU: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CENPU Gene

Function for CENPU Gene

Molecular function for CENPU Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.

Gene Ontology (GO) - Molecular Function for CENPU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CENPU: view
genes like me logo Genes that share phenotypes with CENPU: view

Animal Models for CENPU Gene

MGI Knock Outs for CENPU:

Animal Model Products

miRNA for CENPU Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CENPU Gene

Localization for CENPU Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPU Gene

Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPU gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for CENPU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with CENPU: view

Pathways & Interactions for CENPU Gene

genes like me logo Genes that share pathways with CENPU: view

Pathways by source for CENPU Gene

SIGNOR curated interactions for CENPU Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CENPU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0016032 viral process IEA --
GO:0034080 CENP-A containing nucleosome assembly TAS --
genes like me logo Genes that share ontologies with CENPU: view

Transcripts for CENPU Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CENPU Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c
SP1: - - - -
SP2: - - - -
SP3:
SP4: - - - -
SP5: - -
SP6:
SP7: -

Relevant External Links for CENPU Gene

GeneLoc Exon Structure for
CENPU
ECgene alternative splicing isoforms for
CENPU

Expression for CENPU Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CENPU Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CENPU Gene

This gene is overexpressed in Testis (x17.3).

Protein differential expression in normal tissues from HIPED for CENPU Gene

This gene is overexpressed in Lung (39.0), Pancreatic juice (16.7), and Heart (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CENPU Gene



Protein tissue co-expression partners for CENPU Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CENPU Gene:

CENPU

mRNA Expression by UniProt/SwissProt for CENPU Gene:

Q71F23-CENPU_HUMAN
Tissue specificity: Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines.
genes like me logo Genes that share expression patterns with CENPU: view

Primer Products

Orthologs for CENPU Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLF1IP 34 35
  • 99.26 (n)
cow
(Bos Taurus)
Mammalia CENPU 34 35
  • 80.87 (n)
dog
(Canis familiaris)
Mammalia MLF1IP 34
  • 77.99 (n)
CENPU 35
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpu 34
  • 73.16 (n)
mouse
(Mus musculus)
Mammalia Cenpu 34 16
  • 72.74 (n)
Mlf1ip 35
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPU 35
  • 27 (a)
OneToOne
chicken
(Gallus gallus)
Aves MLF1IP 35
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPU 35
  • 27 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100330652 34
  • 43.69 (n)
CENPU (2 of 2) 35
  • 16 (a)
OneToMany
CU638740.3 35
  • 16 (a)
OneToMany
Species where no ortholog for CENPU was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPU Gene

ENSEMBL:
Gene Tree for CENPU (if available)
TreeFam:
Gene Tree for CENPU (if available)

Paralogs for CENPU Gene

(1) SIMAP similar genes for CENPU Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CENPU Gene

genes like me logo Genes that share paralogs with CENPU: view

No data available for Paralogs for CENPU Gene

Variants for CENPU Gene

Sequence variations from dbSNP and Humsavar for CENPU Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000480 -- 184,697,941(+) CGAAT(A/G)TGTAA intron-variant
rs10000507 -- 184,698,127(+) GCTCG(C/T)ACCAG intron-variant
rs10002618 -- 184,735,599(+) gagcc(A/G)cggcg upstream-variant-2KB
rs10002701 -- 184,735,653(+) tcaag(A/G)tggag upstream-variant-2KB
rs10002919 -- 184,698,511(+) agtgg(C/T)gtgat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPU Gene

Variant ID Type Subtype PubMed ID
esv2474838 CNV insertion 19546169
esv2667890 CNV deletion 23128226
esv28607 CNV loss 19812545
esv3326880 CNV insertion 20981092
esv3565172 CNV deletion 23714750
esv3603466 CNV loss 21293372
nsv1026074 CNV gain 25217958
nsv830168 CNV loss 17160897

Variation tolerance for CENPU Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.16; 84.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CENPU Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPU Gene

Disorders for CENPU Gene

Relevant External Links for CENPU

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPU

No disorders were found for CENPU Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPU Gene

Publications for CENPU Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 2 3 4 64
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 2 3 4 64
  3. Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma. (PMID: 15893739) Hanissian S.H. … Robertson J.H. (Brain Res. 2005) 3 4 22 64
  4. cDNA cloning and characterization of a novel gene encoding the MLF1- interacting protein MLF1IP. (PMID: 15116101) Hanissian S.H. … Morris S.W. (Oncogene 2004) 2 3 4 64
  5. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PMID: 16716197) Izuta H. … Yoda K. (Genes Cells 2006) 3 4 64

Products for CENPU Gene

Sources for CENPU Gene

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