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Aliases for CENPU Gene

Aliases for CENPU Gene

  • Centromere Protein U 2 3
  • Polo-Box-Interacting Protein 1 2 3 4
  • MLF1IP 3 4 6
  • KSHV Latent Nuclear Antigen-Interacting Protein 1 3 4
  • Interphase Centromere Complex Protein 24 3 4
  • Centromere Protein Of 50 KDa 3 4
  • MLF1 Interacting Protein 2 3
  • MLF1-Interacting Protein 3 4
  • CENP50 3 6
  • KLIP1 3 4
  • PBIP1 3 4
  • KSHV Latent Nuclear Antigen Interacting Protein 1 3
  • CENPU50 3
  • CENP-50 4
  • CENP-U 4
  • ICEN24 4

External Ids for CENPU Gene

Previous HGNC Symbols for CENPU Gene

  • MLF1IP

Previous GeneCards Identifiers for CENPU Gene

  • GC04M185616

Summaries for CENPU Gene

Entrez Gene Summary for CENPU Gene

  • The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CENPU Gene

CENPU (Centromere Protein U) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CENPU Gene

  • Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.

Gene Wiki entry for CENPU Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPU Gene

Genomics for CENPU Gene

Genomic Location for CENPU Gene

Start:
184,694,065 bp from pter
End:
184,734,133 bp from pter
Size:
40,069 bases
Orientation:
Minus strand

Genomic View for CENPU Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CENPU Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPU Gene

No data available for Regulatory Elements for CENPU Gene

Proteins for CENPU Gene

  • Protein details for CENPU Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q71F23-CENPU_HUMAN
    Recommended name:
    Centromere protein U
    Protein Accession:
    Q71F23
    Secondary Accessions:
    • A2RRD9
    • Q09GN2
    • Q32Q71
    • Q9H5G1

    Protein attributes for CENPU Gene

    Size:
    418 amino acids
    Molecular mass:
    47522 Da
    Quaternary structure:
    • Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts with the N-terminal domain of Kaposis sarcoma-associated herpesvirus latent nuclear antigen (LNA). Interacts with MLF1. Interacts with PLK1.

    Alternative splice isoforms for CENPU Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPU Gene

Proteomics data for CENPU Gene at MOPED

Post-translational modifications for CENPU Gene

  • Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CENPU Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CENPU Gene

Domains for CENPU Gene

Protein Domains for CENPU Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CENPU: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CENPU Gene

Function for CENPU Gene

Molecular function for CENPU Gene

UniProtKB/Swiss-Prot Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression.

Gene Ontology (GO) - Molecular Function for CENPU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CENPU: view
genes like me logo Genes that share phenotypes with CENPU: view

Animal Models for CENPU Gene

MGI Knock Outs for CENPU:

miRNA for CENPU Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CENPU Gene

Localization for CENPU Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPU Gene

Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates.

Gene Ontology (GO) - Cellular Components for CENPU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with CENPU: view

No data available for Subcellular locations from COMPARTMENTS for CENPU Gene

Pathways for CENPU Gene

genes like me logo Genes that share pathways with CENPU: view

Pathways by source for CENPU Gene

1 BioSystems pathway for CENPU Gene

Gene Ontology (GO) - Biological Process for CENPU Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006334 nucleosome assembly TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with CENPU: view

Transcripts for CENPU Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CENPU Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c
SP1: - - - -
SP2: - - - -
SP3:
SP4: - - - -
SP5: - -
SP6:
SP7: -

Relevant External Links for CENPU Gene

GeneLoc Exon Structure for
CENPU
ECgene alternative splicing isoforms for
CENPU

Expression for CENPU Gene

mRNA expression in normal human tissues for CENPU Gene

mRNA differential expression in normal tissues according to GTEx for CENPU Gene

This gene is overexpressed in Testis (17.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CENPU Gene

mRNA Expression by UniProt/SwissProt for CENPU Gene

Q71F23-CENPU_HUMAN
Tissue specificity: Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines.
genes like me logo Genes that share expressions with CENPU: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CENPU Gene

Orthologs for CENPU Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPU Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLF1IP 35
  • 99.26 (n)
  • 98.27 (a)
MLF1IP 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CENPU 35
  • 80.87 (n)
  • 70.69 (a)
CENPU 36
  • 65 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CENPU 36
  • 61 (a)
OneToOne
MLF1IP 35
  • 77.99 (n)
  • 65.29 (a)
mouse
(Mus musculus)
Mammalia Cenpu 35
  • 72.74 (n)
  • 58.48 (a)
Mlf1ip 16
Mlf1ip 36
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPU 36
  • 27 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpu 35
  • 73.16 (n)
  • 60.26 (a)
chicken
(Gallus gallus)
Aves MLF1IP 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPU 36
  • 27 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CENPU (2 of 2) 36
  • 16 (a)
OneToMany
CU638740.3 36
  • 16 (a)
OneToMany
LOC100330652 35
  • 43.69 (n)
  • 29.94 (a)
Species with no ortholog for CENPU:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPU Gene

ENSEMBL:
Gene Tree for CENPU (if available)
TreeFam:
Gene Tree for CENPU (if available)

Paralogs for CENPU Gene

Selected SIMAP similar genes for CENPU Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CENPU Gene

genes like me logo Genes that share paralogs with CENPU: view

No data available for Paralogs for CENPU Gene

Variants for CENPU Gene

Sequence variations from dbSNP and Humsavar for CENPU Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs745656 -- 184,716,369(-) AGGAG(A/G)GCAAA intron-variant
rs873686 -- 184,717,722(-) AGACA(A/G)TGAAC intron-variant
rs873687 -- 184,717,699(-) AGCCT(C/T)TCAAT intron-variant
rs876838 -- 184,734,333(-) TCTGG(A/C)GCCGG upstream-variant-2KB
rs876839 -- 184,734,038(-) ggcgg(C/G)cccgg reference, missense, nc-transcript-variant, upstream-variant-2KB

Relevant External Links for CENPU Gene

HapMap Linkage Disequilibrium report
CENPU

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CENPU Gene

Disorders for CENPU Gene

No disorders were found for CENPU Gene.

No data available for UniProtKB/Swiss-Prot for CENPU Gene

Publications for CENPU Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 2 3 4
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 2 3 4
  3. Regulation of myeloid leukemia factor-1 interacting protein (MLF1IP) expression in glioblastoma. (PMID: 15893739) Hanissian S.H. … Robertson J.H. (Brain Res. 2005) 3 4 23
  4. cDNA cloning and characterization of a novel gene encoding the MLF1- interacting protein MLF1IP. (PMID: 15116101) Hanissian S.H. … Morris S.W. (Oncogene 2004) 2 3 4
  5. Identification of a novel cellular transcriptional repressor interacting with the latent nuclear antigen of Kaposi's sarcoma- associated herpesvirus. (PMID: 12941884) Pan H.-Y. … Gao S.-J. (J. Virol. 2003) 3 4

Products for CENPU Gene

Sources for CENPU Gene

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