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CENPT Gene

protein-coding   GIFtS: 54
GCID: GC16M067862

Centromere Protein T

(Previous name: chromosome 16 open reading frame 56)
(Previous symbol: C16orf56)
  Search for CENPT
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Centromere Protein T1 2
C16orf561 2 3
Interphase Centromere Complex Protein 222 3
CENP-T2 3
Chromosome 16 Open Reading Frame 561
ICEN223

External Ids:    HGNC: 257871   Entrez Gene: 801522   Ensembl: ENSG000001029017   OMIM: 6115105   UniProtKB: Q96BT33   
ORGUL members:         

Export aliases for CENPT gene to outside databases

Previous GC identifers: GC16M066421 GC16M053735


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CENPT Gene:
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on
which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized
by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128).
CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 (PubMed 16622419)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for CENPT Gene:
CENPT (centromere protein T) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot: CENPT_HUMAN, Q96BT3
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in
assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits
the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into
centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes
at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X
complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a
fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most
further proteins binding downstream. Required for normal chromosome organization and normal progress through
mitosis

Gene Wiki entry for CENPT Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CENPT gene promoter:
         ATF-2   NF-kappaB   GATA-2   AREB6   CRE-BP1   CBF-A   CBF-B   CP1A   NF-kappaB1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCENPT promoter sequence
   Search Chromatin IP Primers for CENPT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CENPT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

CENPT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPT gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M067862:  view genomic region     (about GC identifiers)

Start:
67,862,060 bp from pter      End:
67,881,714 bp from pter
Size:
19,655 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CENPT_HUMAN, Q96BT3 (See protein sequence)
Recommended Name: Centromere protein T  
Size: 561 amino acids; 60423 Da
Subunit: Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and
CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP,
CENPQ, CENPR and CENPS. Part of a centromere complex consisting of CENPA, CENPT and CENPW. Part of a centromere
complex consisting of histone H3, CENPT and CENPW. Interacts (via N-terminus) with the NDC80 complex (Probable).
Component of a heterotetrameric CENP-T-W-S-X complex composed of APITD1/CENPS, STRA13/CENPX, CENPT and CENPW.
Interacts directly with CENPW. Binds DNA
Secondary accessions: Q96I29 Q96IC6 Q96NK9 Q9H901
Alternative splicing: 3 isoforms:  Q96BT3-1   Q96BT3-2   Q96BT3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CENPT: NX_Q96BT3

Explore proteomics data for CENPT at MOPED

Post-translational modifications: 

  • Dynamically phosphorylated at Ser-47 and probably also other sites during the cell cycle. Phosphorylated at Ser-47
    during G2 phase, metaphase and anaphase, but not during telophase or G1 phase1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CENPT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079358.3  
    ENSEMBL proteins: 
     ENSP00000457810   ENSP00000461212   ENSP00000457294   ENSP00000457832   ENSP00000455918  
     ENSP00000457304   ENSP00000456714   ENSP00000454627   ENSP00000455801   ENSP00000454481  
     ENSP00000455638   ENSP00000460542   ENSP00000400140   ENSP00000219172   ENSP00000411594  
    Reactome Protein details: Q96BT3

    CENPT Human Recombinant Protein Products:

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    Novus Biologicals CENPT Protein
    Novus Biologicals CENPT Lysates
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    Cloud-Clone Corp. Proteins for CENPT

     
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    CENPT Assay Products:

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    Cloud-Clone Corp. ELISAs for CENPT
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    Search eBioscience for ELISAs for CENPT 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR009072 Histone-fold
     IPR028255 CENP-T

    Graphical View of Domain Structure for InterPro Entry Q96BT3

    ProtoNet protein and cluster: Q96BT3

    1 Blocks protein domain: IPB003958 Transcription factor CBF/NF-Y/archaeal histone

    UniProtKB/Swiss-Prot: CENPT_HUMAN, Q96BT3
    Domain: The largest part of the sequence forms an elongated and flexible stalk structure that is connected to a
    C-terminal globular domain with a histone-type fold (By similarity)
    Similarity: Belongs to the CENPT family


    Find genes that share domains with CENPT           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPT_HUMAN, Q96BT3
    Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in
    assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits
    the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into
    centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes
    at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X
    complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a
    fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most
    further proteins binding downstream. Required for normal chromosome organization and normal progress through
    mitosis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI19070575
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with CENPT           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CENPT:
     Cell cycle / mitosis defect  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CENPT
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CENPT
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CENPT

    miRNA
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    miRTarBase miRNAs that target CENPT:
    hsa-mir-221-3p (MIRT046930)

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPT

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPT


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CENPT_HUMAN, Q96BT3: Nucleus. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres
    throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore, and may
    connect it to the outer kinetochore via its N-terminus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA--
    GO:0000776kinetochore IDA--
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with CENPT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CENPT About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    5Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with CENPT           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for CENPT
        Chromatin Regulation / Acetylation
    Cell Cycle / Checkpoint Control

    3 Reactome Pathways for CENPT
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CENPT
    Interactions:

        Search GeneGlobe Interaction Network for CENPT

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CENPT (Q96BT32, 3 ENSP000002191724) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SNCBQ161432, 3, ENSP000003080574MINT-64283 I2D: score=4 STRING: ENSP00000308057
    DHX29Q7Z4782, 3MINT-65178 I2D: score=5 
    PPCDCQ96CD22, 3, ENSP000003431904MINT-65179 I2D: score=4 STRING: ENSP00000343190
    TCEA2Q155603, ENSP000003435154I2D: score=4 STRING: ENSP00000343515
    CENPAP494503, ENSP000003368684I2D: score=1 STRING: ENSP00000336868
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007059chromosome segregation IMP--
    GO:0007067mitosis IEA--
    GO:0051276chromosome organization IMP--
    GO:0051382kinetochore assembly IMP--

    Find genes that share ontologies with CENPT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CENPT



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CENPT gene: 
    NM_025082.3  

    Unigene Cluster for CENPT:

    Centromere protein T
    Hs.288382  [show with all ESTs]
    Unigene Representative Sequence: NM_025082
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 36):
    ENST00000569862(uc010vkc.2 uc010vke.1) ENST00000562787(uc002eun.4)
    ENST00000562513 ENST00000436104 ENST00000565157 ENST00000568495 ENST00000574569
    ENST00000563885 ENST00000564817 ENST00000566758 ENST00000564128 ENST00000562947
    ENST00000562462 ENST00000565713 ENST00000568069 ENST00000564538 ENST00000566067
    ENST00000562338
    miRNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CENPT
      QuantiFast Probe-based Assays in human, mouse, rat CENPT

    Additional mRNA sequence: 

    AK056097.1 AK225399.1 AK291527.1 AK297570.1 AK300887.1 AK301621.1 BC007642.1 BC007864.2 
    BC015202.2 

    Selected DOTS entries (see all 30):

    DT.456413  DT.95264015  DT.100828498  DT.120718391  DT.120718490  DT.120718357  DT.120718478  DT.91771873 
    DT.120718457  DT.91878330  DT.100828488  DT.91771871  DT.120718375  DT.120718440  DT.120718498  DT.95264032 
    DT.100828499  DT.102836977  DT.100828506  DT.120718359  DT.102836978  DT.120718345  DT.91964723  DT.100828500 

    Selected AceView cDNA sequences (see all 333):

    BM855285 CA421166 BX093588 AI652143 CR594388 AW007397 AI922541 BQ926231 
    CR594299 T32225 BI520467 CR601879 CD557829 AL562878 BQ574664 BM922216 
    AJ709255 F11779 BI918238 AW958547 BI833230 BM547429 CR600277 BC042204 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CENPT (see all 14)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b ^
    SP1:                    -                                                           -     -           -                                                         
    SP2:                                                                                -     -           -                                                         
    SP3:                                                                                -     -     -     -                                                         
    SP4:                                                                                -                 -                                                         
    SP5:                                                                                -                 -                                                         

    ExUns: 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17
    SP1:  -                                   -               
    SP2:                                      -               
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for CENPT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CENPT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCCGCAA
    CENPT Expression
    About this image


    CENPT expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
    CENPT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CENPT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.288382
        Custom PCR Arrays for CENPT
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for CENPT gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenpt1 , 5 centromere protein T1, 5 74.56(n)1
    65.54(a)1
      8 (53.05 cM)5
    3203941  NM_177150.21  NP_796124.11 
     1058446785 
    chicken
    (Gallus gallus)
    Aves CENPT6
    Centromere protein T
    24(a)
    1 ↔ 1
    11(861024-877706)
    lizard
    (Anolis carolinensis)
    Reptilia CENPT6
    centromere protein T
    64(a)
    1 ↔ 1
    GL343295.1(682555-683450)
    zebrafish
    (Danio rerio)
    Actinopterygii CENPT6
    centromere protein T
    18(a)
    1 ↔ 1
    21(6351085-6374255) ENSDARG00000091271


    ENSEMBL Gene Tree for CENPT (if available)
    TreeFam Gene Tree for CENPT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CENPT (see all 289)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021532401,2
    --67862590(+) TCAAGA/CGCCTT 2 A syn10--------
    rs1881591381,2
    C--67862706(+) AGGGGC/GATGCC 2 P A mis10--------
    rs2022320951,2
    C--67862715(+) CCTGAA/CCAACA 2 V F mis10--------
    rs735938041,2
    C,F--67863064(+) TTCCCG/AATTCT 1 -- int13Minor allele frequency- A:0.04WA 122
    rs1929185851,2
    --67863239(+) TACCCA/GTAGGA 1 -- int10--------
    rs2014345511,2
    C--67863341(+) CAGGCA/GCTGGG 2 A V mis10--------
    rs118621351,2
    H--67863436(+) AAGGGG/TGGGGT 1 -- int10--------
    rs37437331,2
    C,F,A,H--67863451(+) GGGATT/CCCAGG 1 -- int130Minor allele frequency- C:0.41EA NS NA WA CSA 4253
    rs1852377111,2
    --67863513(+) TGGTGG/TGCCCC 1 -- int10--------
    rs1482235491,2
    --67863521(+) CCCACC/GTAGCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CENPT (67862060 - 67881714 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CENPT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv906813CNV Loss21882294
    nsv524363CNV Loss19592680
    nsv522852CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CENPT
    DNA2.0 Custom Variant and Variant Library Synthesis for CENPT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611510    OMIM disorders: --


    Find genes that share disorders with CENPT           About GenesLikeMe


    Export disorders for CENPT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CENPT gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with CENPT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)1, 2, 3 Foltz D.R....Cleveland D.W. (Nat. Cell Biol. 2006)
    2. Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state. (PubMed id 21695110)1, 2 Prendergast L.... Sullivan K.F. (PLoS Biol. 2011)
    3. Cancer-upregulated gene 2 (CUG2), a new component of centromere complex, is required for kinetochore function. (PubMed id 19533040)1, 2 Kim H.... Lee S. (Mol. Cells 2009)
    4. CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. (PubMed id 19070575)1, 2 Hori T....Fukagawa T. (Cell 2008)
    5. Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B. (PubMed id 19412974)1, 2 Hellwig D....Diekmann S. (J. Biophotonics 2008)
    6. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PubMed id 16622420)1, 3 Okada M.... Fukagawa T. (Nat. Cell Biol. 2006)
    7. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PubMed id 16716197)1, 2 Izuta H.... Yoda K. (Genes Cells 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. CENP-T provides a structural platform for outer kinetochore assembly. (PubMed id 23334297)1 Nishino T....Fukagawa T. (EMBO J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80152 HGNC: 25787 AceView: FLJ13111 Ensembl:ENSG00000102901 euGenes: HUgn80152
    ECgene: CENPT H-InvDB: CENPT

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CENPT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CENPT gene:
    Search GeneIP for patents involving CENPT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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