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Aliases for CENPT Gene

Aliases for CENPT Gene

  • Centromere Protein T 2 3 5
  • Interphase Centromere Complex Protein 22 3 4
  • C16orf56 3 4
  • CENP-T 3 4
  • Chromosome 16 Open Reading Frame 56 2
  • ICEN22 4

External Ids for CENPT Gene

Previous HGNC Symbols for CENPT Gene

  • C16orf56

Previous GeneCards Identifiers for CENPT Gene

  • GC16M066421
  • GC16M067862
  • GC16M053735

Summaries for CENPT Gene

Entrez Gene Summary for CENPT Gene

  • The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CENPT Gene

CENPT (Centromere Protein T) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by Rho GTPases. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for CENPT Gene

  • Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.

Gene Wiki entry for CENPT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPT Gene

Genomics for CENPT Gene

Regulatory Elements for CENPT Gene

Enhancers for CENPT Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CENPT on UCSC Golden Path with GeneCards custom track

Promoters for CENPT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CENPT on UCSC Golden Path with GeneCards custom track

Genomic Location for CENPT Gene

Chromosome:
16
Start:
67,828,157 bp from pter
End:
67,847,811 bp from pter
Size:
19,655 bases
Orientation:
Minus strand

Genomic View for CENPT Gene

Genes around CENPT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPT Gene

Proteins for CENPT Gene

  • Protein details for CENPT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BT3-CENPT_HUMAN
    Recommended name:
    Centromere protein T
    Protein Accession:
    Q96BT3
    Secondary Accessions:
    • Q96I29
    • Q96IC6
    • Q96NK9
    • Q9H901

    Protein attributes for CENPT Gene

    Size:
    561 amino acids
    Molecular mass:
    60423 Da
    Quaternary structure:
    • Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Part of a centromere complex consisting of CENPA, CENPT and CENPW. Part of a centromere complex consisting of histone H3, CENPT and CENPW. Interacts (via N-terminus) with the NDC80 complex (Probable). Component of a heterotetrameric CENP-T-W-S-X complex composed of APITD1/CENPS, STRA13/CENPX, CENPT and CENPW. Interacts directly with CENPW. Binds DNA.

    Alternative splice isoforms for CENPT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPT Gene

Proteomics data for CENPT Gene at MOPED

Post-translational modifications for CENPT Gene

  • Dynamically phosphorylated at Ser-47 and probably also other sites during the cell cycle. Phosphorylated at Ser-47 during G2 phase, metaphase and anaphase, but not during telophase or G1 phase.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CENPT (CENPT)

No data available for DME Specific Peptides for CENPT Gene

Domains & Families for CENPT Gene

Protein Domains for CENPT Gene

Suggested Antigen Peptide Sequences for CENPT Gene

Graphical View of Domain Structure for InterPro Entry

Q96BT3

UniProtKB/Swiss-Prot:

CENPT_HUMAN :
  • The largest part of the sequence forms an elongated and flexible stalk structure that is connected to a C-terminal globular domain with a histone-type fold.
  • Belongs to the CENPT family.
Domain:
  • The largest part of the sequence forms an elongated and flexible stalk structure that is connected to a C-terminal globular domain with a histone-type fold.
Family:
  • Belongs to the CENPT family.
genes like me logo Genes that share domains with CENPT: view

No data available for Gene Families for CENPT Gene

Function for CENPT Gene

Molecular function for CENPT Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.
genes like me logo Genes that share phenotypes with CENPT: view

Animal Model Products

miRNA for CENPT Gene

miRTarBase miRNAs that target CENPT

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPT Gene

Localization for CENPT Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPT Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore, and may connect it to the outer kinetochore via its N-terminus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPT Gene COMPARTMENTS Subcellular localization image for CENPT gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2

No data available for Gene Ontology (GO) - Cellular Components for CENPT Gene

Pathways & Interactions for CENPT Gene

genes like me logo Genes that share pathways with CENPT: view

Pathways by source for CENPT Gene

Interacting Proteins for CENPT Gene

Gene Ontology (GO) - Biological Process for CENPT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IMP 21529714
GO:0007062 sister chromatid cohesion TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CENPT: view

No data available for SIGNOR curated interactions for CENPT Gene

Drugs & Compounds for CENPT Gene

No Compound Related Data Available

Transcripts for CENPT Gene

Unigene Clusters for CENPT Gene

Centromere protein T:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CENPT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12a · 12b ^
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: - -
SP6: - -
SP7: -
SP8: - - - - - - - - -
SP9:
SP10:
SP11:
SP12: -
SP13: -
SP14:

ExUns: 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17
SP1: - -
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for CENPT Gene

GeneLoc Exon Structure for
CENPT
ECgene alternative splicing isoforms for
CENPT

Expression for CENPT Gene

mRNA expression in normal human tissues for CENPT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CENPT Gene

This gene is overexpressed in Fetal testis (36.3), Peripheral blood mononuclear cells (20.5), and Fetal ovary (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CENPT Gene



SOURCE GeneReport for Unigene cluster for CENPT Gene Hs.288382

genes like me logo Genes that share expression patterns with CENPT: view

Protein tissue co-expression partners for CENPT Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CENPT Gene

Orthologs for CENPT Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPT Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia CENPT 35
  • 82.88 (n)
  • 73.67 (a)
mouse
(Mus musculus)
Mammalia Cenpt 35
  • 74.56 (n)
  • 65.54 (a)
Cenpt 16
Cenpt 36
  • 61 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CENPT 35
  • 98.99 (n)
  • 97.68 (a)
CENPT 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpt 35
  • 74.33 (n)
  • 63.5 (a)
cow
(Bos Taurus)
Mammalia CENPT 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPT 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPT 36
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPT 36
  • 24 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPT 36
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CENPT 36
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5930 36
  • 31 (a)
OneToOne
Species with no ortholog for CENPT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPT Gene

ENSEMBL:
Gene Tree for CENPT (if available)
TreeFam:
Gene Tree for CENPT (if available)

Paralogs for CENPT Gene

No data available for Paralogs for CENPT Gene

Variants for CENPT Gene

Sequence variations from dbSNP and Humsavar for CENPT Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs12102580 - 67,832,054(+) CCTGC(A/G)GTGCT upstream-variant-2KB, reference, missense
rs8063064 -- 67,832,927(+) TTTTA(A/T)AATCT intron-variant, upstream-variant-2KB
rs13333317 -- 67,838,348(+) caggc(A/C)cggtg intron-variant
rs13336148 -- 67,840,175(+) tagcc(A/G)ggcac intron-variant
rs4783605 -- 67,836,726(+) gtgcc(A/C)ccacg intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CENPT Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv906813 CNV Loss 21882294

Variation tolerance for CENPT Gene

Residual Variation Intolerance Score: 55.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.03; 60.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CENPT Gene

Disorders for CENPT Gene

Relevant External Links for CENPT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPT

No disorders were found for CENPT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPT Gene

Publications for CENPT Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 2 3 4 67
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Distinct organization and regulation of the outer kinetochore KMN network downstream of CENP-C and CENP-T. (PMID: 25660545) Rago F. … Cheeseman I.M. (Curr. Biol. 2015) 3
  5. HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment. (PMID: 25843710) Tachiwana H. … Almouzni G. (Cell Rep 2015) 3

Products for CENPT Gene

Sources for CENPT Gene

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