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Aliases for CENPS-CORT Gene

Aliases for CENPS-CORT Gene

  • CENPS-CORT Readthrough 2 3
  • APITD1-CORT Readthrough 2 3 5
  • APITD1-CORT 3 5
  • APITD1-CORT Protein 3

External Ids for CENPS-CORT Gene

Previous HGNC Symbols for CENPS-CORT Gene

  • APITD1-CORT

Summaries for CENPS-CORT Gene

Entrez Gene Summary for CENPS-CORT Gene

  • This locus represents naturally occurring read-through transcription between the neighboring APITD1 (apoptosis-inducing, TAF9-like domain 1) and CORT (cortistatin) genes. Alternative splicing results in multiple transcript variants, two of which encode fusion proteins that share sequence identity with the products of each individual gene. [provided by RefSeq, Aug 2011]

GeneCards Summary for CENPS-CORT Gene

CENPS-CORT (CENPS-CORT Readthrough) is a Protein Coding gene. Among its related pathways are Fanconi anemia pathway. An important paralog of this gene is CENPS.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPS-CORT Gene

Genomics for CENPS-CORT Gene

Regulatory Elements for CENPS-CORT Gene

Enhancers for CENPS-CORT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G010494 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 +66.8 66845 4.7 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 ZNF263 PEX14 DFFA CENPS CENPS-CORT CORT ENSG00000203469 ENSG00000271989 PGD GC01P010513
GH01G010449 1.3 Ensembl ENCODE 12.3 +21.0 20977 2.2 HDGF PKNOX1 ARNT AGO1 SIN3A FEZF1 ZNF2 YY1 ZNF766 FOS PGD ENSG00000271989 CENPS CENPS-CORT DFFA PEX14 C1orf127 CORT ENSG00000203469
GH01G010331 0.4 dbSUPER 10.5 -98.4 -98439 1.2 PBX2 PGD RNU6-37P CENPS CENPS-CORT ENSG00000228150 LZIC NMNAT1 RN7SKP269 KIF1B RN7SL731P
GH01G010427 1.1 Ensembl ENCODE 0.7 -1.8 -1823 0.6 ARNT ARID4B SIN3A BMI1 ZNF2 RAD21 ZNF121 ZNF143 ZNF654 CEBPB PGD CENPS CENPS-CORT
GH01G010429 1.1 ENCODE 0.7 +0.5 517 2.1 HDGF PKNOX1 FOXA2 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 PGD ENSG00000271989 ENSG00000226849 EXOSC10 CENPS SRM CENPS-CORT
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CENPS-CORT on UCSC Golden Path with GeneCards custom track

Promoters for CENPS-CORT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000001275 798 1401 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 CBX5

Genomic Location for CENPS-CORT Gene

Chromosome:
1
Start:
10,430,102 bp from pter
End:
10,452,153 bp from pter
Size:
22,052 bases
Orientation:
Plus strand

Genomic View for CENPS-CORT Gene

Genes around CENPS-CORT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPS-CORT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPS-CORT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPS-CORT Gene

Proteins for CENPS-CORT Gene

  • Protein details for CENPS-CORT Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087WT10
    Recommended name:
    APITD1-CORT readthrough
    Protein Accession:
    A0A087WT10

    Protein attributes for CENPS-CORT Gene

    Size:
    143 amino acids
    Molecular mass:
    16498 Da
    Quaternary structure:
    No Data Available
  • Protein details for CENPS-CORT Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0U1RQL5
    Recommended name:
    APITD1-CORT readthrough
    Protein Accession:
    A0A0U1RQL5

    Protein attributes for CENPS-CORT Gene

    Size:
    49 amino acids
    Molecular mass:
    5699 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CENPS-CORT Gene

Post-translational modifications for CENPS-CORT Gene

No Post-translational modifications

Other Protein References for CENPS-CORT Gene

No data available for DME Specific Peptides for CENPS-CORT Gene

Domains & Families for CENPS-CORT Gene

Protein Domains for CENPS-CORT Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CENPS-CORT: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CENPS-CORT Gene

Function for CENPS-CORT Gene

Gene Ontology (GO) - Molecular Function for CENPS-CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
GO:0003690 double-stranded DNA binding IBA --
GO:0005179 hormone activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with CENPS-CORT: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CENPS-CORT Gene

Localization for CENPS-CORT Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPS-CORT gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CENPS-CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0005576 extracellular region IEA --
GO:0043240 Fanconi anaemia nuclear complex IBA --
GO:0071821 FANCM-MHF complex IEA --
genes like me logo Genes that share ontologies with CENPS-CORT: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CENPS-CORT Gene

Pathways & Interactions for CENPS-CORT Gene

SuperPathways for CENPS-CORT Gene

SuperPathway Contained pathways
1 Fanconi anemia pathway
genes like me logo Genes that share pathways with CENPS-CORT: view

Pathways by source for CENPS-CORT Gene

1 KEGG pathway for CENPS-CORT Gene

Interacting Proteins for CENPS-CORT Gene

Gene Ontology (GO) - Biological Process for CENPS-CORT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006312 mitotic recombination IBA --
GO:0031297 replication fork processing IBA --
GO:0036297 interstrand cross-link repair IBA --
GO:0051382 kinetochore assembly IEA --
genes like me logo Genes that share ontologies with CENPS-CORT: view

No data available for SIGNOR curated interactions for CENPS-CORT Gene

Drugs & Compounds for CENPS-CORT Gene

No Compound Related Data Available

Transcripts for CENPS-CORT Gene

mRNA/cDNA for CENPS-CORT Gene

(4) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CENPS-CORT Gene

No ASD Table

Relevant External Links for CENPS-CORT Gene

GeneLoc Exon Structure for
CENPS-CORT
ECgene alternative splicing isoforms for
CENPS-CORT

Expression for CENPS-CORT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with CENPS-CORT: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPS-CORT Gene

Orthologs for CENPS-CORT Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPS-CORT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APITD1 34 35
  • 99.52 (n)
cow
(Bos Taurus)
Mammalia APITD1 34 35
  • 88.11 (n)
dog
(Canis familiaris)
Mammalia APITD1 34
  • 86.5 (n)
rat
(Rattus norvegicus)
Mammalia Apitd1 34
  • 81.94 (n)
mouse
(Mus musculus)
Mammalia Apitd1 34 16 35
  • 81.2 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 53 (a)
OneToMany
chicken
(Gallus gallus)
Aves APITD1 34 35
  • 66.67 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia apitd1 34
  • 66.38 (n)
zebrafish
(Danio rerio)
Actinopterygii apitd1 34 35
  • 63.31 (n)
Species where no ortholog for CENPS-CORT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPS-CORT Gene

ENSEMBL:
Gene Tree for CENPS-CORT (if available)
TreeFam:
Gene Tree for CENPS-CORT (if available)

Paralogs for CENPS-CORT Gene

Paralogs for CENPS-CORT Gene

genes like me logo Genes that share paralogs with CENPS-CORT: view

Variants for CENPS-CORT Gene

Sequence variations from dbSNP and Humsavar for CENPS-CORT Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000356299 -- 10,442,091(+) AAAAA(A/G)AAAAA intron-variant
rs1000780672 -- 10,437,962(+) TCACC(A/G)TGTTG intron-variant
rs1000904944 -- 10,431,427(+) CGTCA(C/T)CTTGA intron-variant
rs1001106622 -- 10,444,503(+) GGTGC(C/T)CGTCC intron-variant
rs1001417607 -- 10,448,348(+) GGAAG(A/G)ACCAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CENPS-CORT Gene

Variant ID Type Subtype PubMed ID
esv2758920 CNV gain+loss 17122850
esv2764192 CNV gain 21179565

Variation tolerance for CENPS-CORT Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CENPS-CORT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPS-CORT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPS-CORT Gene

Disorders for CENPS-CORT Gene

Relevant External Links for CENPS-CORT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPS-CORT

No disorders were found for CENPS-CORT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPS-CORT Gene

Publications for CENPS-CORT Gene

  1. The Dual Estrogen Receptor I+ Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. (PMID: 26487511) Han S.J. … O'Malley B.W. (Mol. Pharmacol. 2016) 3 64
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  3. A novel 1p36.2 located gene, APITD1, with tumour-suppressive properties and a putative p53-binding domain, shows low expression in neuroblastoma tumours. (PMID: 15328517) Krona C. … Martinsson T. (Br. J. Cancer 2004) 3 64
  4. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for CENPS-CORT Gene

Sources for CENPS-CORT Gene

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