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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CENPQ Gene

protein-coding   GIFtS: 50
GCID: GC06P049431

Centromere Protein Q

(Previous name: chromosome 6 open reading frame 139)
(Previous symbol: C6orf139)
  Search for CENPQ
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Centromere Protein Q1 2
C6orf1391 2 3
CENP-Q2 3
Chromosome 6 Open Reading Frame 1391

External Ids:    HGNC: 213471   Entrez Gene: 551662   Ensembl: ENSG000000316917   OMIM: 6115065   UniProtKB: Q7L2Z93   

Export aliases for CENPQ gene to outside databases

Previous GC identifers: GC06P049540 GC06P049160


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CENPQ Gene:
CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA
(MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et
al., 2006 (PubMed 16622420)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CENPQ Gene: 
CENPQ (centromere protein Q) is a protein-coding gene. Among its related super-pathways are Mitotic Anaphase and Mitotic Prometaphase.

UniProtKB/Swiss-Prot: CENPQ_HUMAN, Q7L2Z9
Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is
involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in
incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CENPQ gene promoter:
         SRF   Nkx3-1 v4   SRF (504 AA)   Olf-1   HSF1 (long)   FAC1   Ik-2   HSF1short   Cart-1   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCENPQ promoter sequence
   Search SABiosciences Chromatin IP Primers for CENPQ

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPQ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.3   Ensembl cytogenetic band:  6p12.3   HGNC cytogenetic band: 6p12.3

CENPQ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPQ gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P049431:  view genomic region     (about GC identifiers)

Start:
49,431,091 bp from pter      End:
49,460,820 bp from pter
Size:
29,730 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CENPQ_HUMAN, Q7L2Z9 (See protein sequence)
Recommended Name: Centromere protein Q  
Size: 268 amino acids; 30595 Da
Subunit: Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and
CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH,
CENPM, CENPN, CENPT and MLF1IP/CENPU
Subcellular location: Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The
CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex
Sequence caution: Sequence=BAA91672.1; Type=Erroneous initiation;
Secondary accessions: A8KAF1 Q6IN61 Q9NVS5

Explore the universe of human proteins at neXtProt for CENPQ: NX_Q7L2Z9

Explore proteomics data for CENPQ at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7L2Z9

  • CENPQ Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CENPQ Protein Expression
    REFSEQ proteins: NP_060602.2  
    ENSEMBL proteins: 
     ENSP00000337289  
    Reactome Protein details: Q7L2Z9
    Human Recombinant Protein Products for CENPQ: 
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    Novus Biologicals CENPQ Lysate
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    Cloud-Clone Corp. Proteins for CENPQ 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--

    CENPQ for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR025212 CAD_CENP-Q

    Graphical View of Domain Structure for InterPro Entry Q7L2Z9

    ProtoNet protein and cluster: Q7L2Z9


    CENPQ for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPQ_HUMAN, Q7L2Z9
    Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is
    involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in
    incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex

    Phenotypes:
         2 GenomeRNAi human phenotypes for CENPQ:

     Decreased POU5F1-GFP protein e  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CENPQ 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CENPQ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CENPQ 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidCENPQ 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CENPQ About                                                                                                See pathways by source

    SuperPathContained pathways About
    1M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    2Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93
    3Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    4Packaging Of Telomere Ends
    Nucleosome assembly0.46
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.46
    5Meiotic Synapsis
    Chromosome Maintenance0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/12        Reactome Pathways for CENPQ (see all 12)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Nucleosome assembly
    Mitotic Anaphase



    CENPQ for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CENPQ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/81 Interacting proteins for CENPQ (Q7L2Z93 ENSP000003372894) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C19orf57Q0VDD73, ENSP000002543364I2D: score=1 STRING: ENSP00000254336
    AURKBENSP000003139504STRING: ENSP00000313950
    BIRC5ENSP000003016334STRING: ENSP00000301633
    BUB1ENSP000003025304STRING: ENSP00000302530
    BUB1BENSP000002875984STRING: ENSP00000287598
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006334nucleosome assembly TAS--
    GO:0034080CENP-A containing nucleosome assembly at centromere TAS--

    CENPQ for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CENPQ

    Search CenterWatch for drugs/clinical trials and news about CENPQ

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CENPQ gene: 
    NM_018132.3  

    Unigene Cluster for CENPQ:

    Centromere protein Q
    Hs.88663  [show with all ESTs]
    Unigene Representative Sequence: NM_018132
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000335783(uc003ozh.1)
    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate CENPQ (see all 15):
    hsa-miR-3910 hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-1324 hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidCENPQ 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CENPQ
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CENPQ

    Additional mRNA sequence: 

    AK001407.1 AK293016.1 BC016279.1 

    5 DOTS entries:

    DT.456104  DT.40294124  DT.99931849  DT.86841373  DT.95322694 

    24/63 AceView cDNA sequences (see all 63):

    AW591121 BU163879 BQ921236 NM_018132 AA291197 AA279768 AI619625 BM552832 
    AI291478 BI861538 AU150780 AA279729 BU620476 AA447043 BF512001 BM849729 
    BE882520 T06789 AU128500 BU730041 BX462676 AA811376 BM704150 AW194164 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CENPQ expression in normal human tissues (normalized intensities)      CENPQ embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAACCTTCA
    CENPQ Expression
    About this image


    CENPQ expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Amnion (Extraembryonic Tissues)
             amniotic fluid   

    See CENPQ Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CENPQ

    SOURCE GeneReport for Unigene cluster: Hs.88663
        SABiosciences Custom PCR Arrays for CENPQ
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPQ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CENPQ gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenpq1 , 5 centromere protein Q1, 5 77.99(n)1
    66.79(a)1
      17 (19.55 cM)5
    838151  NM_031863.31  NP_114069.11 
     409230515 
    chicken
    (Gallus gallus)
    Aves CENPQ1 centromere protein Q 56.19(n)
    40.17(a)
      422048  NM_001044649.1  NP_001038114.1 
    lizard
    (Anolis carolinensis)
    Reptilia CENPQ6
    centromere protein Q
    29(a)
    1 ↔ 1
    1(139504011-139529373)
    zebrafish
    (Danio rerio)
    Actinopterygii CENPQ6
    centromere protein Q
    29(a)
    1 ↔ 1
    1(408913-427013)


    ENSEMBL Gene Tree for CENPQ (if available)
    TreeFam Gene Tree for CENPQ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/495 SNPs in CENPQ are shown (see all 495)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs587651181,2
    C--49179729(+) CTGCT-/CG    
       GCGAT
    TGGCG
    1 -- int11Minor allele frequency- CGGCGAT:0.00NA 2
    rs1907026751,2
    --49433080(+) CAGAAA/TGGTCA 1 -- int10--------
    rs77590711,2
    C,F,A,H--49433198(+) ctagaC/Tagcat 1 -- int18Minor allele frequency- T:0.44NA WA CSA EA 367
    rs1825758191,2
    --49433221(+) GGCTGC/TTTTGT 1 -- int10--------
    rs1879940271,2
    --49433279(+) TACCTA/GGAACT 1 -- int10--------
    rs1124544161,2
    C,F--49433334(+) TTGTAG/CTTTCA 1 -- int11Minor allele frequency- C:0.50CSA 2
    rs77391691,2
    C,A,H--49433373(+) cctcaG/Agaacc 1 -- int14Minor allele frequency- A:0.24NA WA EA 360
    rs1385162041,2
    --49433657(+) AGTTTC/GCAGCC 1 -- int10--------
    rs69012421,2
    C,F,H--49433737(+) ggtgtG/Aatttt 1 -- int111Minor allele frequency- A:0.07NS EA NA WA 1656
    rs1386363871,2
    C--49434109(+) CCTTTA/GGTTTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for CENPQ (49431091 - 49460820 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CENPQ:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv885881CNV Loss21882294
    nsv441996CNV CNV18776908

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CENPQ for disorders           About MalaCards
    OMIM gene information: 611506    OMIM disorders: --


    CENPQ for disorders           About GeneDecksing

    Genetic Association Database (GAD): CENPQ

    Export disorders for CENPQ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CENPQ gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with CENPQ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PubMed id 16622420)1, 2, 3 Okada M....Fukagawa T. (2006)
    2. The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)1, 2, 3 Foltz D.R....Cleveland D.W. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    7. Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex. (PubMed id 23028590)1 Eskat A....Diekmann S. (2012)
    8. Mammalian polo-like kinase 1-dependent regulation of the PBIP1-CENP-Q complex at kinetochores. (PubMed id 21454580)1 Kang Y.H....Lee K.S. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55166 HGNC: 21347 AceView: C6orf139 Ensembl:ENSG00000031691 euGenes: HUgn55166
    ECgene: CENPQ H-InvDB: CENPQ

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CENPQ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CENPQ gene:
    Search GeneIP for patents involving CENPQ

    GeneCards and IP:
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