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Aliases for CENPQ Gene

Aliases for CENPQ Gene

  • Centromere Protein Q 2 3
  • C6orf139 3 4
  • CENP-Q 3 4
  • Chromosome 6 Open Reading Frame 139 2

External Ids for CENPQ Gene

Previous HGNC Symbols for CENPQ Gene

  • C6orf139

Previous GeneCards Identifiers for CENPQ Gene

  • GC06P049540
  • GC06P049160

Summaries for CENPQ Gene

Entrez Gene Summary for CENPQ Gene

  • CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CENPQ Gene

CENPQ (Centromere Protein Q) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CENPQ Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPQ Gene

Genomics for CENPQ Gene

Regulatory Elements for CENPQ Gene

Genomic Location for CENPQ Gene

Start:
49,463,341 bp from pter
End:
49,493,107 bp from pter
Size:
29,767 bases
Orientation:
Plus strand

Genomic View for CENPQ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CENPQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPQ Gene

Proteins for CENPQ Gene

  • Protein details for CENPQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L2Z9-CENPQ_HUMAN
    Recommended name:
    Centromere protein Q
    Protein Accession:
    Q7L2Z9
    Secondary Accessions:
    • A8KAF1
    • Q6IN61
    • Q9NVS5

    Protein attributes for CENPQ Gene

    Size:
    268 amino acids
    Molecular mass:
    30595 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.
    SequenceCaution:
    • Sequence=BAA91672.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CENPQ Gene

Proteomics data for CENPQ Gene at MOPED

Post-translational modifications for CENPQ Gene

  • Ubiquitination at Lys78
  • Modification sites at PhosphoSitePlus

Other Protein References for CENPQ Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CENPQ Gene

Domains for CENPQ Gene

Protein Domains for CENPQ Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPQ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CENPQ: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CENPQ Gene

Function for CENPQ Gene

Molecular function for CENPQ Gene

UniProtKB/Swiss-Prot Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Phenotypes for CENPQ Gene

GenomeRNAi human phenotypes for CENPQ:
genes like me logo Genes that share phenotypes with CENPQ: view

miRNA for CENPQ Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CENPQ Gene

Localization for CENPQ Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPQ Gene

Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPQ Gene COMPARTMENTS Subcellular localization image for CENPQ gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CENPQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with CENPQ: view

Pathways for CENPQ Gene

genes like me logo Genes that share pathways with CENPQ: view

Pathways by source for CENPQ Gene

Gene Ontology (GO) - Biological Process for CENPQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006334 nucleosome assembly TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0034080 CENP-A containing nucleosome assembly TAS --
genes like me logo Genes that share ontologies with CENPQ: view

Transcripts for CENPQ Gene

mRNA/cDNA for CENPQ Gene

Unigene Clusters for CENPQ Gene

Centromere protein Q:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CENPQ Gene

No ASD Table

Relevant External Links for CENPQ Gene

GeneLoc Exon Structure for
CENPQ
ECgene alternative splicing isoforms for
CENPQ

Expression for CENPQ Gene

mRNA expression in normal human tissues for CENPQ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPQ Gene

SOURCE GeneReport for Unigene cluster for CENPQ Gene Hs.88663

genes like me logo Genes that share expressions with CENPQ: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CENPQ Gene

Orthologs for CENPQ Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPQ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPQ 35
  • 97.26 (n)
  • 94.78 (a)
CENPQ 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CENPQ 35
  • 85.02 (n)
  • 74.91 (a)
CENPQ 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CENPQ 35
  • 84.34 (n)
  • 74.06 (a)
CENPQ 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cenpq 35
  • 77.99 (n)
  • 66.79 (a)
Cenpq 16
Cenpq 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPQ 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPQ 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpq 35
  • 75.87 (n)
  • 60.82 (a)
chicken
(Gallus gallus)
Aves CENPQ 35
  • 56.19 (n)
  • 40.17 (a)
CENPQ 36
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPQ 36
  • 30 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101885540 35
  • 46.43 (n)
  • 33.48 (a)
Species with no ortholog for CENPQ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPQ Gene

ENSEMBL:
Gene Tree for CENPQ (if available)
TreeFam:
Gene Tree for CENPQ (if available)

Paralogs for CENPQ Gene

No data available for Paralogs for CENPQ Gene

Variants for CENPQ Gene

Sequence variations from dbSNP and Humsavar for CENPQ Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1471538 -- 49,492,555(-) AACTA(C/T)TAGAT utr-variant-3-prime
rs1471539 -- 49,492,439(-) CTACA(C/T)TAGAT utr-variant-3-prime
rs2019540 -- 49,484,453(-) CTTTG(A/T)CTTAG intron-variant
rs2086421 -- 49,483,198(-) cacca(A/T)tctac intron-variant
rs2086422 -- 49,482,628(-) ctgag(C/T)aaatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPQ Gene

Variant ID Type Subtype PubMed ID
nsv441996 CNV CNV 18776908
nsv885881 CNV Loss 21882294

Relevant External Links for CENPQ Gene

HapMap Linkage Disequilibrium report
CENPQ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPQ Gene

Disorders for CENPQ Gene

Relevant External Links for CENPQ

Genetic Association Database (GAD)
CENPQ
genes like me logo Genes that share disorders with CENPQ: view

No data available for UniProtKB/Swiss-Prot for CENPQ Gene

Publications for CENPQ Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 2 3 4
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 2 3 4
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CENPQ Gene

Sources for CENPQ Gene

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