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Aliases for CENPQ Gene

Aliases for CENPQ Gene

  • Centromere Protein Q 2 3 5
  • C6orf139 3 4
  • CENP-Q 3 4
  • Chromosome 6 Open Reading Frame 139 2

External Ids for CENPQ Gene

Previous HGNC Symbols for CENPQ Gene

  • C6orf139

Previous GeneCards Identifiers for CENPQ Gene

  • GC06P049540
  • GC06P049160

Summaries for CENPQ Gene

Entrez Gene Summary for CENPQ Gene

  • CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CENPQ Gene

CENPQ (Centromere Protein Q) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Mitotic Prometaphase.

UniProtKB/Swiss-Prot for CENPQ Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579).

Additional gene information for CENPQ Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPQ Gene

Genomics for CENPQ Gene

Regulatory Elements for CENPQ Gene

Enhancers for CENPQ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H049555 1.5 Ensembl ENCODE dbSUPER 12.8 +93.2 93246 1 PKNOX1 FOXA2 ATF1 ARID4B SIN3A ZNF766 ATF7 FOS SP3 SP5 CENPQ PGK2 LOC101927020 LOC101927048 MUT C6orf141 CYP2AC1P
GH06H048824 1.6 FANTOM5 Ensembl ENCODE dbSUPER 6.9 -636.2 -636235 4 TBP JUN MAX RAD21 POLR2A SMC3 RCOR1 FOSL2 FOS MAFK CENPQ PIR62700 GC06M048881
GH06H049549 1.5 Ensembl ENCODE dbSUPER 6.7 +89.2 89230 5 PKNOX1 ZNF493 ZFP64 SIN3A ZNF2 GLIS2 FOS KLF7 ZNF202 SP3 MUT CENPQ C6orf141 CYP2AC1P
GH06H049564 1 FANTOM5 ENCODE 9.2 +102.7 102737 2 JUND POLR2A JUN ZNF169 ETV4 MAX FOS ZNF644 RARA C6orf141 CENPQ LOC101927020 CYP2AC1P
GH06H049532 1.2 Ensembl ENCODE 7.5 +69.0 68973 0 YBX3 ELF3 TBP ARNT ZBTB40 ZNF2 RAD21 CHAMP1 RFX5 SCRT2 GLYATL3 CENPQ GC06M049537 GC06P049517
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CENPQ on UCSC Golden Path with GeneCards custom track

Genomic Location for CENPQ Gene

Chromosome:
6
Start:
49,463,341 bp from pter
End:
49,493,107 bp from pter
Size:
29,767 bases
Orientation:
Plus strand

Genomic View for CENPQ Gene

Genes around CENPQ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPQ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPQ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPQ Gene

Proteins for CENPQ Gene

  • Protein details for CENPQ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L2Z9-CENPQ_HUMAN
    Recommended name:
    Centromere protein Q
    Protein Accession:
    Q7L2Z9
    Secondary Accessions:
    • A8KAF1
    • Q6IN61
    • Q9NVS5

    Protein attributes for CENPQ Gene

    Size:
    268 amino acids
    Molecular mass:
    30595 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.
    SequenceCaution:
    • Sequence=BAA91672.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for CENPQ Gene

Post-translational modifications for CENPQ Gene

  • Phosphorylation at Ser-50 is essential for CENPE recruitment to kinetochores and orderly chromosome congression.
  • Ubiquitination at Lys78
  • Modification sites at PhosphoSitePlus

Other Protein References for CENPQ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CENPQ Gene

Domains & Families for CENPQ Gene

Gene Families for CENPQ Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CENPQ Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPQ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CENPQ: view

No data available for UniProtKB/Swiss-Prot for CENPQ Gene

Function for CENPQ Gene

Molecular function for CENPQ Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579).
genes like me logo Genes that share phenotypes with CENPQ: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CENPQ
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPQ Gene

Localization for CENPQ Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPQ Gene

Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPQ gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CENPQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CENPQ: view

Pathways & Interactions for CENPQ Gene

genes like me logo Genes that share pathways with CENPQ: view

Gene Ontology (GO) - Biological Process for CENPQ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0034080 CENP-A containing nucleosome assembly TAS --
GO:0051310 metaphase plate congression IMP 25395579
GO:1905342 positive regulation of protein localization to kinetochore IMP 25395579
genes like me logo Genes that share ontologies with CENPQ: view

No data available for SIGNOR curated interactions for CENPQ Gene

Drugs & Compounds for CENPQ Gene

No Compound Related Data Available

Transcripts for CENPQ Gene

mRNA/cDNA for CENPQ Gene

Unigene Clusters for CENPQ Gene

Centromere protein Q:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CENPQ
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CENPQ Gene

No ASD Table

Relevant External Links for CENPQ Gene

GeneLoc Exon Structure for
CENPQ
ECgene alternative splicing isoforms for
CENPQ

Expression for CENPQ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CENPQ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CENPQ Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CENPQ Gene



Protein tissue co-expression partners for CENPQ Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CENPQ Gene:

CENPQ

SOURCE GeneReport for Unigene cluster for CENPQ Gene:

Hs.88663

Evidence on tissue expression from TISSUES for CENPQ Gene

  • Stomach(4.1)
genes like me logo Genes that share expression patterns with CENPQ: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPQ Gene

Orthologs for CENPQ Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPQ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPQ 33 34
  • 97.26 (n)
cow
(Bos Taurus)
Mammalia CENPQ 33 34
  • 85.02 (n)
dog
(Canis familiaris)
Mammalia CENPQ 33 34
  • 84.34 (n)
mouse
(Mus musculus)
Mammalia Cenpq 33 16 34
  • 77.99 (n)
rat
(Rattus norvegicus)
Mammalia Cenpq 33
  • 75.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CENPQ 34
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPQ 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPQ 33 34
  • 56.19 (n)
lizard
(Anolis carolinensis)
Reptilia CENPQ 34
  • 30 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101885540 33
  • 46.43 (n)
Species where no ortholog for CENPQ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPQ Gene

ENSEMBL:
Gene Tree for CENPQ (if available)
TreeFam:
Gene Tree for CENPQ (if available)

Paralogs for CENPQ Gene

No data available for Paralogs for CENPQ Gene

Variants for CENPQ Gene

Sequence variations from dbSNP and Humsavar for CENPQ Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs553218776 Uncertain significance 49,463,141(+) GGGCG(G/T)CTGCA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs778890521 Uncertain significance 49,463,198(+) CTCCC(A/C/T)GCCCT upstream-variant-2KB, utr-variant-5-prime
rs886061562 Uncertain significance 49,463,218(-) CGGTT(-/T)GTGTG upstream-variant-2KB, utr-variant-5-prime
rs3729619 Benign 49,463,261(-) GGCCT(A/C/T)CGCCC upstream-variant-2KB, utr-variant-5-prime
rs1000381259 -- 49,478,862(+) AGTGG(C/T)GATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPQ Gene

Variant ID Type Subtype PubMed ID
dgv10654n54 CNV gain 21841781
dgv10655n54 CNV gain 21841781
dgv10656n54 CNV gain 21841781
dgv1768e212 CNV gain 25503493
dgv1769e212 CNV gain 25503493
dgv1770e212 CNV gain 25503493
dgv5960n100 CNV gain 25217958
esv2763934 CNV gain 21179565
esv3424715 CNV duplication 20981092
esv3576156 CNV gain 25503493
esv3608946 CNV gain 21293372
nsv1019611 CNV gain 25217958
nsv441996 CNV gain 18776908

Variation tolerance for CENPQ Gene

Residual Variation Intolerance Score: 69.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.08; 96.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CENPQ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPQ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPQ Gene

Disorders for CENPQ Gene

Relevant External Links for CENPQ

Genetic Association Database (GAD)
CENPQ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPQ

No disorders were found for CENPQ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPQ Gene

Publications for CENPQ Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz DR … Cleveland DW (Nature cell biology 2006) 2 3 4 60
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M … Fukagawa T (Nature cell biology 2006) 2 3 4 60
  3. Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways. (PMID: 25395579) Bancroft J … McAinsh AD (Journal of cell science 2015) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for CENPQ Gene

Sources for CENPQ Gene

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