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Aliases for CENPP Gene

Aliases for CENPP Gene

  • Centromere Protein P 2 3 5
  • CENP-P 3 4

External Ids for CENPP Gene

Previous GeneCards Identifiers for CENPP Gene

  • GC09P094127
  • GC09P095087
  • GC09P064765

Summaries for CENPP Gene

Entrez Gene Summary for CENPP Gene

  • CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CENPP Gene

CENPP (Centromere Protein P) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases.

UniProtKB/Swiss-Prot for CENPP Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPP Gene

Genomics for CENPP Gene

Regulatory Elements for CENPP Gene

Promoters for CENPP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CENPP on UCSC Golden Path with GeneCards custom track

Genomic Location for CENPP Gene

Chromosome:
9
Start:
92,325,457 bp from pter
End:
92,620,533 bp from pter
Size:
295,077 bases
Orientation:
Plus strand

Genomic View for CENPP Gene

Genes around CENPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPP Gene

Proteins for CENPP Gene

  • Protein details for CENPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IPU0-CENPP_HUMAN
    Recommended name:
    Centromere protein P
    Protein Accession:
    Q6IPU0
    Secondary Accessions:
    • B3KRA5
    • B3KS17
    • Q5T9F8
    • Q5T9F9

    Protein attributes for CENPP Gene

    Size:
    288 amino acids
    Molecular mass:
    33165 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.
    SequenceCaution:
    • Sequence=CAI12591.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12592.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CENPP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPP Gene

Proteomics data for CENPP Gene at MOPED

Post-translational modifications for CENPP Gene

  • Ubiquitination at Lys 37
  • Modification sites at PhosphoSitePlus

Other Protein References for CENPP Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for CENPP

No data available for DME Specific Peptides for CENPP Gene

Domains & Families for CENPP Gene

Protein Domains for CENPP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CENPP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CENPP Gene

Function for CENPP Gene

Molecular function for CENPP Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Phenotypes for CENPP Gene

GenomeRNAi human phenotypes for CENPP:
genes like me logo Genes that share phenotypes with CENPP: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPP Gene

Localization for CENPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPP Gene

Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPP Gene COMPARTMENTS Subcellular localization image for CENPP gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1
extracellular 1
lysosome 1
mitochondrion 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CENPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CENPP: view

Pathways & Interactions for CENPP Gene

genes like me logo Genes that share pathways with CENPP: view

Pathways by source for CENPP Gene

Gene Ontology (GO) - Biological Process for CENPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with CENPP: view

No data available for SIGNOR curated interactions for CENPP Gene

Drugs & Compounds for CENPP Gene

No Compound Related Data Available

Transcripts for CENPP Gene

Unigene Clusters for CENPP Gene

Centromere protein P:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CENPP Gene

No ASD Table

Relevant External Links for CENPP Gene

GeneLoc Exon Structure for
CENPP
ECgene alternative splicing isoforms for
CENPP

Expression for CENPP Gene

mRNA expression in normal human tissues for CENPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CENPP Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPP Gene



SOURCE GeneReport for Unigene cluster for CENPP Gene Hs.713775

genes like me logo Genes that share expression patterns with CENPP: view

Protein tissue co-expression partners for CENPP Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CENPP Gene

Orthologs for CENPP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPP 36
  • 99 (a)
OneToOne
CENPP 35
  • 99.65 (n)
  • 98.96 (a)
cow
(Bos Taurus)
Mammalia CENPP 36
  • 72 (a)
OneToOne
CENPP 35
  • 83.56 (n)
  • 76.04 (a)
dog
(Canis familiaris)
Mammalia CENPP 35
  • 82.06 (n)
  • 73.26 (a)
CENPP 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cenpp 16
Cenpp 36
  • 67 (a)
OneToOne
Cenpp 35
  • 78.32 (n)
  • 67.83 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia CENPP 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC679342 35
  • 78.61 (n)
  • 69.53 (a)
chicken
(Gallus gallus)
Aves CENPP 35
  • 63.45 (n)
  • 51.75 (a)
CENPP 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPP 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpp 35
  • 55.31 (n)
  • 44.07 (a)
zebrafish
(Danio rerio)
Actinopterygii cenpp 36
  • 35 (a)
OneToOne
cenpp 35
  • 54.5 (n)
  • 46.56 (a)
Species with no ortholog for CENPP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPP Gene

ENSEMBL:
Gene Tree for CENPP (if available)
TreeFam:
Gene Tree for CENPP (if available)

Paralogs for CENPP Gene

(1) SIMAP similar genes for CENPP Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CENPP Gene

genes like me logo Genes that share paralogs with CENPP: view

No data available for Paralogs for CENPP Gene

Variants for CENPP Gene

Sequence variations from dbSNP and Humsavar for CENPP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs494013 -- 92,565,326(+) aaatc(A/T)taatg intron-variant
rs522531 -- 92,560,867(-) aaaag(A/C)caaga intron-variant
rs527233 -- 92,565,189(-) CTGTA(A/G)AAGCT intron-variant
rs473423 -- 92,565,329(-) aaaca(A/T)taaga intron-variant
rs1152761 -- 92,356,939(+) tgtta(C/T)gaact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPP Gene

Variant ID Type Subtype PubMed ID
nsv893573 CNV Gain 21882294
esv1019101 CNV Insertion 17803354
nsv527206 CNV Loss 19592680
esv2738772 CNV Deletion 23290073
esv2658382 CNV Deletion 23128226

Variation tolerance for CENPP Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CENPP Gene

HapMap Linkage Disequilibrium report
CENPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPP Gene

Disorders for CENPP Gene

Relevant External Links for CENPP

Genetic Association Database (GAD)
CENPP
Human Genome Epidemiology (HuGE) Navigator
CENPP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPP

No disorders were found for CENPP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPP Gene

Publications for CENPP Gene

  1. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 2 3 4 67
  2. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex. (PMID: 23028590) Eskat A. … Diekmann S. (PLoS ONE 2012) 3

Products for CENPP Gene

Sources for CENPP Gene

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