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Aliases for CENPP Gene

Aliases for CENPP Gene

  • Centromere Protein P 2 3 5
  • CENP-P 3 4

External Ids for CENPP Gene

Previous GeneCards Identifiers for CENPP Gene

  • GC09P094127
  • GC09P095087
  • GC09P064765

Summaries for CENPP Gene

Entrez Gene Summary for CENPP Gene

  • CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CENPP Gene

CENPP (Centromere Protein P) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Mitotic Prometaphase.

UniProtKB/Swiss-Prot for CENPP Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Additional gene information for CENPP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPP Gene

Genomics for CENPP Gene

Regulatory Elements for CENPP Gene

Enhancers for CENPP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H092323 1.4 ENCODE dbSUPER 59.8 0.0 -26 3 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D NOL8 CENPP MTND4P15 IARS LINC00475 ZNF484 ENSG00000236115 HSPE1P22 RPL21P82 RPL21P86
GH09H092408 1.1 Ensembl ENCODE dbSUPER 61.2 +84.6 84624 3 CEBPB CEBPG ZIC2 ATF2 PRDM6 ZNF316 ATF7 TRIM24 EMSY ZNF18 CENPP OGN NOL8 ECM2 OMD
GH09H092478 1.3 Ensembl ENCODE dbSUPER 45.4 +156.5 156485 5.9 PKNOX1 MXI1 ARNT JUN MAX FEZF1 ZBTB40 BATF BCL11B FOSL1 CENPP OGN ASPN OMD
GH09H092533 1.2 Ensembl ENCODE dbSUPER 40.5 +210.5 210505 4.3 PKNOX1 FOXA2 TAF1 HLF EBF1 YY1 GATA3 JUND HNF4G HNF4A CENPP ASPN OMD OGN IPPK BICD2 ECM2 MIR4670
GH09H092607 1.4 Ensembl ENCODE dbSUPER 28.2 +284.7 284736 5.6 MLX ZNF195 THRB RARA ZNF350 RCOR1 ZNF174 REST ZNF398 ZNF662 LINC00475 PHF2 NOL8 CENPP IARS ZNF484 MTND4P15 IPPK CARD19 PIR58934
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CENPP on UCSC Golden Path with GeneCards custom track

Promoters for CENPP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000237877 43 2201 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D

Genomic Locations for CENPP Gene

Genomic Locations for CENPP Gene
chr9:92,325,457-92,620,533
(GRCh38/hg38)
Size:
295,077 bases
Orientation:
Plus strand
chr9:95,087,741-95,382,815
(GRCh37/hg19)

Genomic View for CENPP Gene

Genes around CENPP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPP Gene

Proteins for CENPP Gene

  • Protein details for CENPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IPU0-CENPP_HUMAN
    Recommended name:
    Centromere protein P
    Protein Accession:
    Q6IPU0
    Secondary Accessions:
    • B3KRA5
    • B3KS17
    • Q5T9F8
    • Q5T9F9

    Protein attributes for CENPP Gene

    Size:
    288 amino acids
    Molecular mass:
    33165 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.
    SequenceCaution:
    • Sequence=CAI12591.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12592.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CENPP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPP Gene

Post-translational modifications for CENPP Gene

  • Ubiquitination at posLast=3737
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CENPP Gene

Domains & Families for CENPP Gene

Gene Families for CENPP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CENPP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPP Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CENPP: view

No data available for UniProtKB/Swiss-Prot for CENPP Gene

Function for CENPP Gene

Molecular function for CENPP Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Gene Ontology (GO) - Molecular Function for CENPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CENPP: view

Phenotypes for CENPP Gene

GenomeRNAi human phenotypes for CENPP:
genes like me logo Genes that share phenotypes with CENPP: view

Clone Products

  • Addgene plasmids for CENPP

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPP Gene

Localization for CENPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPP Gene

Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPP gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CENPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with CENPP: view

Pathways & Interactions for CENPP Gene

genes like me logo Genes that share pathways with CENPP: view

Gene Ontology (GO) - Biological Process for CENPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0034080 CENP-A containing nucleosome assembly TAS,IEA --
genes like me logo Genes that share ontologies with CENPP: view

No data available for SIGNOR curated interactions for CENPP Gene

Drugs & Compounds for CENPP Gene

No Compound Related Data Available

Transcripts for CENPP Gene

Unigene Clusters for CENPP Gene

Centromere protein P:
Representative Sequences:

Clone Products

  • Addgene plasmids for CENPP

Alternative Splicing Database (ASD) splice patterns (SP) for CENPP Gene

No ASD Table

Relevant External Links for CENPP Gene

GeneLoc Exon Structure for
CENPP
ECgene alternative splicing isoforms for
CENPP

Expression for CENPP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CENPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CENPP Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CENPP Gene



Protein tissue co-expression partners for CENPP Gene

NURSA nuclear receptor signaling pathways regulating expression of CENPP Gene:

CENPP

SOURCE GeneReport for Unigene cluster for CENPP Gene:

Hs.713775

Evidence on tissue expression from TISSUES for CENPP Gene

  • Muscle(4.3)
  • Nervous system(3.6)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with CENPP: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPP Gene

Orthologs for CENPP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPP 33 34
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia CENPP 33 34
  • 83.56 (n)
dog
(Canis familiaris)
Mammalia CENPP 33 34
  • 82.06 (n)
rat
(Rattus norvegicus)
Mammalia LOC679342 33
  • 78.61 (n)
mouse
(Mus musculus)
Mammalia Cenpp 33 16 34
  • 78.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CENPP 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPP 33 34
  • 63.45 (n)
lizard
(Anolis carolinensis)
Reptilia CENPP 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpp 33
  • 55.31 (n)
zebrafish
(Danio rerio)
Actinopterygii cenpp 33 34
  • 54.5 (n)
Species where no ortholog for CENPP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPP Gene

ENSEMBL:
Gene Tree for CENPP (if available)
TreeFam:
Gene Tree for CENPP (if available)

Paralogs for CENPP Gene

(1) SIMAP similar genes for CENPP Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CENPP Gene

genes like me logo Genes that share paralogs with CENPP: view

No data available for Paralogs for CENPP Gene

Variants for CENPP Gene

Sequence variations from dbSNP and Humsavar for CENPP Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000004894 -- 92,581,268(+) GGGTG(C/T)TGGCA intron-variant
rs1000015031 -- 92,384,132(+) GAAAG(C/T)AGTAT intron-variant, utr-variant-3-prime
rs1000021779 -- 92,434,414(+) AATGA(A/G)TAATT intron-variant
rs1000031047 -- 92,479,716(+) ACAAT(G/T)AATCT intron-variant
rs1000034795 -- 92,480,031(+) TGTTT(C/T)ATTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPP Gene

Variant ID Type Subtype PubMed ID
nsv982321 CNV duplication 23825009
nsv527206 CNV loss 19592680
nsv1137481 CNV deletion 24896259
nsv1128504 CNV deletion 24896259
nsv1124448 CNV deletion 24896259
nsv1115209 CNV deletion 24896259
nsv1053205 CNV loss 25217958
nsv1052846 CNV loss 25217958
nsv1049599 CNV loss 25217958
nsv1047337 CNV loss 25217958
nsv1046733 CNV gain 25217958
nsv1045165 CNV loss 25217958
esv3891693 CNV gain 25118596
esv3621085 CNV loss 21293372
esv3621084 CNV loss 21293372
esv3621082 CNV loss 21293372
esv3621081 CNV loss 21293372
esv3621080 CNV loss 21293372
esv3621079 CNV loss 21293372
esv3621078 CNV loss 21293372
esv2738772 CNV deletion 23290073
esv2658382 CNV deletion 23128226
esv1019101 CNV insertion 17803354

Variation tolerance for CENPP Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CENPP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPP Gene

Disorders for CENPP Gene

Relevant External Links for CENPP

Genetic Association Database (GAD)
CENPP
Human Genome Epidemiology (HuGE) Navigator
CENPP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPP

No disorders were found for CENPP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPP Gene

Publications for CENPP Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz DR … Cleveland DW (Nature cell biology 2006) 2 3 4 60
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M … Fukagawa T (Nature cell biology 2006) 2 3 4 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for CENPP Gene

  • Addgene plasmids for CENPP

Sources for CENPP Gene

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