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CENPO Gene

protein-coding   GIFtS: 52
GCID: GC02P025016

Centromere Protein O

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centromere Protein O1 2     ICEN-362
Interphase Centromere Complex Protein 362 3     Centromeric Protein O2
CENP-O2 3     ICEN363
MCM21R2 3     

External Ids:    HGNC: 281521   Entrez Gene: 791722   Ensembl: ENSG000001380927   OMIM: 6115045   UniProtKB: Q9BU643   

Export aliases for CENPO gene to outside databases

Previous GC identifers: GC02P024869 GC02P024754


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CENPO Gene:
This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the
centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and
checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms
have been observed for this gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for CENPO Gene:
CENPO (centromere protein O) is a protein-coding gene.

UniProtKB/Swiss-Prot: CENPO_HUMAN, Q9BU64
Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is
involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in
incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Modulates the kinetochore-bound levels of NDC80 complex

Gene Wiki entry for CENPO Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CENPO gene promoter:
         Elk-1   Sox5   Pax-5   ATF-2   AP-2gamma   E4BP4   Pax-3   HOXA5   AP-2beta   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCENPO promoter sequence
   Search Chromatin IP Primers for CENPO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CENPO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

CENPO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPO gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P025016:  view genomic region     (about GC identifiers)

Start:
25,016,005 bp from pter      End:
25,045,245 bp from pter
Size:
29,241 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CENPO_HUMAN, Q9BU64 (See protein sequence)
Recommended Name: Centromere protein O  
Size: 300 amino acids; 33786 Da
Subunit: Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and
CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH,
CENPM, CENPN, CENPT and CENPU
Secondary accessions: B2RDC0 D6W536 Q53T55 Q96JV3
Alternative splicing: 2 isoforms:  Q9BU64-1   Q9BU64-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CENPO: NX_Q9BU64

Explore proteomics data for CENPO at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CENPO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186732.1  NP_077298.1  

    ENSEMBL proteins: 
     ENSP00000370214   ENSP00000417787   ENSP00000260662  
    Reactome Protein details: Q9BU64

    CENPO Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CENPO

     
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    antibodies-online kits for CENPO (20 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018464 CENP-O

    Graphical View of Domain Structure for InterPro Entry Q9BU64

    ProtoNet protein and cluster: Q9BU64


    Find genes that share domains with CENPO           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPO_HUMAN, Q9BU64
    Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is
    involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in
    incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
    Modulates the kinetochore-bound levels of NDC80 complex

    Phenotypes:
         2 GenomeRNAi human phenotypes for CENPO:

     Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Cenpo (no phenotypes)

    Find genes that share phenotypes with CENPO           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CENPO

    miRNA
    Products:
        
    miRTarBase miRNAs that target CENPO:
    hsa-mir-218-5p (MIRT024229)

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    Selected qRT-PCR Assays for microRNAs that regulate CENPO (see all 43):
    hsa-miR-579 hsa-miR-1914* hsa-miR-3616-5p hsa-miR-106a hsa-miR-488 hsa-miR-301a hsa-miR-3921 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidCENPO 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CENPO

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CENPO_HUMAN, Q9BU64: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=The CENPA-CAD
    complex is probably recruited on centromeres by the CENPA-NAC complex
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore ----
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with CENPO           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CENPO About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Packaging Of Telomere Ends
    Chromosome Maintenance0.62
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    Nucleosome assembly0.59
    4Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92


    Find genes that share SuperPaths with CENPO           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4 Reactome Pathways for CENPO
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    Deposition of new CENPA-containing nucleosomes at the centromere


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CENPO
    Interactions:

        Search GeneGlobe Interaction Network for CENPO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CENPO (Q9BU642, 3 ENSP000002606624) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP170P1Q96L142, 3MINT-66747 I2D: score=2 
    NECAB2Q7Z6G32, 3, ENSP000003074494MINT-66522 I2D: score=4 STRING: ENSP00000307449
    RNF40O751503, ENSP000003256774I2D: score=1 STRING: ENSP00000325677
    CENPAP494503, ENSP000003368684I2D: score=1 STRING: ENSP00000336868
    AURKBENSP000003139504STRING: ENSP00000313950
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006334nucleosome assembly TAS--
    GO:0034080CENP-A containing nucleosome assembly at centromere TAS--
    GO:0034508centromere complex assembly ----

    Find genes that share ontologies with CENPO           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CENPO



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CENPO gene (2 alternative transcripts): 
    NM_001199803.1  NM_024322.2  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000473476 ENST00000380834(uc002rfq.2) ENST00000473706(uc002rfp.2)
    ENST00000491031 ENST00000486527 ENST00000498362 ENST00000464156 ENST00000395845
    ENST00000260662
    miRNA
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    hsa-miR-579 hsa-miR-1914* hsa-miR-3616-5p hsa-miR-106a hsa-miR-488 hsa-miR-301a hsa-miR-3921 hsa-miR-519a
    SwitchGear 3'UTR luciferase reporter plasmidCENPO 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CENPO
      QuantiFast Probe-based Assays in human, mouse, rat CENPO

    Selected AceView cDNA sequences (see all 157):

    CR592453 AI745347 BX110829 BQ877757 BC002870 CR617150 BX362229 BG826931 
    AL514456 BM825424 BM789497 AI989831 BU932129 AA832400 AA400482 BX462781 
    BE267667 AL120752 AA677770 CA488839 CR599751 AA779288 AI597803 BG170063 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CENPO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CENPO Expression
    About this image


    CENPO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
    CENPO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CENPO Protein Expression
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CENPO gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenpo1 , 5 centromere protein O1, 5 75.39(n)1
    67.45(a)1
      12 (2.02 cM)5
    525041  NM_134046.51  NP_598807.21 
     41960045 
    chicken
    (Gallus gallus)
    Aves CENPO1 centromere protein O 57.39(n)
    46.52(a)
      422014  NM_001031099.1  NP_001026270.1 
    lizard
    (Anolis carolinensis)
    Reptilia CENPO6
    centromere protein O
    42(a)
    1 ↔ 1
    GL343333.1(639306-649152)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cenpo1 centromere protein O 51.5(n)
    40.97(a)
      733516  NM_001044442.2  NP_001037907.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cenpo1 centromere protein O 46.41(n)
    33.33(a)
      100126022  NM_001105702.1  NP_001099172.1 


    ENSEMBL Gene Tree for CENPO (if available)
    TreeFam Gene Tree for CENPO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CENPO gene

    Find genes that share paralogs with CENPO           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CENPO
    PGOHUM00000235328 PGOHUM00000235714


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CENPO (see all 511)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2004220211,2
    --25018254(+) TTTGA-/CCTTTT 2 -- int10--------
    rs46657201,2
    C,F,A--25018256(+) TTGACC/TTTTTT 2 -- int111Minor allele frequency- T:0.39NA WA CSA EA 373
    rs46657211,2
    C,F,A--25018261(+) TTTTTT/CTGGGA 2 -- int19Minor allele frequency- C:0.39NA WA EA 370
    rs1441530191,2
    C--25018295(+) ATGCAA/GTCATA 2 -- int10--------
    rs1511486551,2
    --25018357(+) GCAACA/GCTAAA 2 -- int10--------
    rs1823362751,2
    --25018363(+) CTAAAA/CAACAA 2 -- int10--------
    rs352134721,2
    C,F,H--25018509(+) AACTTT/CGGGAA 2 -- int123Minor allele frequency- C:0.05NS EA NA 3066
    rs1866223701,2
    --25018656(+) GCTCCA/GTGAGG 2 -- int10--------
    rs1393919471,2
    --25018672(+) GACTTA/CGTTTT 2 -- int10--------
    rs67171001,2
    C,F,H--25018761(+) AGATTT/GGTGAA 2 -- int127Minor allele frequency- G:0.04NS EA NA WA CSA 2359

    HapMap Linkage Disequilibrium report for CENPO (25016005 - 25045245 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CENPO:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508831CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CENPO
    DNA2.0 Custom Variant and Variant Library Synthesis for CENPO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611504    OMIM disorders: --


    Find genes that share disorders with CENPO           About GenesLikeMe

    Genetic Association Database (GAD): CENPO
    Human Genome Epidemiology (HuGE) Navigator: CENPO (1 document)

    Export disorders for CENPO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CENPO gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with CENPO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PubMed id 16622420)1, 2, 3 Okada M.... Fukagawa T. (Nat. Cell Biol. 2006)
    2. The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)1, 2, 3 Foltz D.R....Cleveland D.W. (Nat. Cell Biol. 2006)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The CENP-A NAC/CAD kinetochore complex controls chromosome congression and spindle bipolarity. (PubMed id 18007590)1, 2 McClelland S.E.... Meraldi P. (EMBO J. 2007)
    5. The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation. (PubMed id 16932742)1, 2 McAinsh A.D.... Sorger P.K. (EMBO J. 2006)
    6. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PubMed id 16716197)1, 2 Izuta H.... Yoda K. (Genes Cells 2006)
    7. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79172 HGNC: 28152 AceView: MGC11266 Ensembl:ENSG00000138092 euGenes: HUgn79172
    ECgene: CENPO H-InvDB: CENPO

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CENPO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for CENPO gene:
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