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CENPN Gene

protein-coding   GIFtS: 52
GCID: GC16P081040

Centromere Protein N

(Previous name: chromosome 16 open reading frame 60)
(Previous symbol: C16orf60)
  Search for CENPN
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centromere Protein N1 2     ICEN322 3
C16orf601 2 3     Chromosome 16 Open Reading Frame 601
Interphase Centromere Complex Protein 322 3     BM0392
CENP-N2 3     

External Ids:    HGNC: 308731   Entrez Gene: 558392   Ensembl: ENSG000001664517   OMIM: 6115095   UniProtKB: Q96H223   

Export aliases for CENPN gene to outside databases

Previous GC identifers: GC16P079598 GC16P066796


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CENPN Gene:
The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore
assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere.
Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript
variants that encode different protein isoforms. (provided by RefSeq, Jul 2012)

GeneCards Summary for CENPN Gene:
CENPN (centromere protein N) is a protein-coding gene.

UniProtKB/Swiss-Prot: CENPN_HUMAN, Q96H22
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in
assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits
the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into
centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA
nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently
align the chromosomes on a metaphase plate

Gene Wiki entry for CENPN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CENPN gene promoter:
         TBP   AP-1   Nkx2-5   E47   FOXC1   POU2F1   TFIID   POU2F1a   FOXO4   Hand1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CENPN promoter sequence
   Search Chromatin IP Primers for CENPN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CENPN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.2   Ensembl cytogenetic band:  16q23.2   HGNC cytogenetic band: 16q23.2

CENPN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPN gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P081040:  view genomic region     (about GC identifiers)

Start:
81,040,103 bp from pter      End:
81,066,719 bp from pter
Size:
26,617 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CENPN_HUMAN, Q96H22 (See protein sequence)
Recommended Name: Centromere protein N  
Size: 339 amino acids; 39555 Da
Subunit: Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and
CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP,
CENPQ, CENPR and CENPS. Interacts directly with CENPA
Secondary accessions: A8MZE6 B3KN53 B4DJD1 B4DPY7 C9JJM5 D3DUK8 E7ES30 E7ETS3 Q9NZ83
Alternative splicing: 5 isoforms:  Q96H22-1   Q96H22-2   Q96H22-3   Q96H22-4   Q96H22-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CENPN: NX_Q96H22

Explore proteomics data for CENPN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys207, Lys276
  • Modification sites at PhosphoSitePlus

  • See CENPN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001094094.2  NP_001094095.2  NP_001257402.1  NP_001257403.1  NP_060925.2  

    ENSEMBL proteins: 
     ENSP00000305608   ENSP00000299572   ENSP00000395235   ENSP00000377007   ENSP00000393991  
     ENSP00000454327   ENSP00000454337   ENSP00000456413  
    Reactome Protein details: Q96H22

    CENPN Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for CENPN

     
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    Search eBioscience for ELISAs for CENPN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007902 Chl4/mis15/CENP-N
     IPR027715 CENP-N

    Graphical View of Domain Structure for InterPro Entry Q96H22

    ProtoNet protein and cluster: Q96H22


    Find genes that share domains with CENPN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPN_HUMAN, Q96H22
    Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in
    assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits
    the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into
    centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA
    nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently
    align the chromosomes on a metaphase plate

    Phenotypes:
         1 GenomeRNAi human phenotype for CENPN:

     Cell cycle / mitosis defect 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CENPN
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CENPN

    miRNA
    Products:
        
    miRTarBase miRNAs that target CENPN:
    hsa-mir-19b-3p (MIRT031109)

    Block miRNA regulation of human, mouse, rat CENPN using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CENPN:
    hsa-miR-223
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CENPN

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    GenScript: all cDNA clones in your preferred vector (see all 3): CENPN (NM_001100624)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CENPN_HUMAN, Q96H22: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore
    domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells
    exit mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton3
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region ----
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CENPN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CENPN About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Packaging Of Telomere Ends
    Chromosome Maintenance0.62
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    Nucleosome assembly0.59
    4Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92


    Find genes that share SuperPaths with CENPN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Reactome Pathways for CENPN
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    Deposition of new CENPA-containing nucleosomes at the centromere


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CENPN
    Interactions:

        Search GeneGlobe Interaction Network for CENPN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CENPN (Q96H223 ENSP000003770074) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKTIPQ9H8T03, ENSP000003002454I2D: score=1 STRING: ENSP00000300245
    CENPAP494503, ENSP000003368684I2D: score=1 STRING: ENSP00000336868
    SRIP306263I2D: score=1 
    AURKBENSP000003139504STRING: ENSP00000313950
    BIRC5ENSP000003016334STRING: ENSP00000301633
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006334nucleosome assembly TAS--
    GO:0007059chromosome segregation IEA--
    GO:0007067mitosis ----
    GO:0034080CENP-A containing nucleosome assembly at centromere TAS--

    Find genes that share ontologies with CENPN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CENPN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CENPN gene (5 alternative transcripts): 
    NM_001100624.2  NM_001100625.2  NM_001270473.1  NM_001270474.1  NM_018455.5  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305850(uc002ffx.2 uc010vnl.1 uc010vnm.1 uc002ffy.4)
    ENST00000299572(uc002ffw.4) ENST00000439957 ENST00000393335 ENST00000569461
    ENST00000428963 ENST00000564669 ENST00000568445 ENST00000562943
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CENPN:
    hsa-miR-223
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CENPN
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): CENPN (NM_001100624)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CENPN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPN
    Primer
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    OriGene qPCR primer pairs and template standards for CENPN
    OriGene qSTAR qPCR primer pairs in human, mouse for CENPN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CENPN
      QuantiTect SYBR Green Assays in human, mouse, rat CENPN
      QuantiFast Probe-based Assays in human, mouse, rat CENPN

    Selected AceView cDNA sequences (see all 102):

    AW181929 AW263161 CB140392 BU181606 BU522031 AI826399 AA599331 BE301525 
    AA512883 AA683129 BC008972 AI950600 AA767812 BG033737 AI817677 BU664978 
    AI566865 BG943329 BG163367 BM264511 BX281764 BU933213 AK026313 BM827585 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CENPN (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
    SP1:                                -                 -                                   -     -                                 
    SP2:                                -                 -                             -                                             
    SP3:                                                  -                             -     -     -                                 
    SP4:                                -                 -           -                 -                                             
    SP5:                                -                 -                                                                           


    ECgene alternative splicing isoforms for CENPN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CENPN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAAACCTT
    CENPN Expression
    About this image


    CENPN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Proerythroblasts Hematopoietic Bone Marrow
             Bone marrow-derived hematopoietic stem cells (family)
    CENPN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CENPN Protein Expression
        Custom PCR Arrays for CENPN
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CENPN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CENPN gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenpn1 , 5 centromere protein N1, 5 79.03(n)1
    73.29(a)1
      8 (63.34 cM)5
    721551  NM_028131.31  NP_082407.11 
     1169217405 
    chicken
    (Gallus gallus)
    Aves CENPN1 centromere protein N 66.17(n)
    60.96(a)
      693246  NM_001044670.1  NP_001038135.1 
    lizard
    (Anolis carolinensis)
    Reptilia CENPN6
    centromere protein N
    45(a)
    1 ↔ 1
    LGc(5665462-5677898)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.132282 Xenopus laevis transcribed sequence with weak similarity more 73.79(n)    BU916641.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cenpn1 centromere protein N 51.64(n)
    35.58(a)
      368856  NM_001002341.1  NP_001002341.1 


    ENSEMBL Gene Tree for CENPN (if available)
    TreeFam Gene Tree for CENPN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CENPN gene
    1 SIMAP similar gene for CENPN using alignment to 4 protein entries:     CENPN_HUMAN (see all proteins):
    C16orf60

    Find genes that share paralogs with CENPN           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CENPN
    PGOHUM00000240134 PGOHUM00000240863


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CENPN (see all 749)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs111503341,2
    C,F,A,H--81042542(+) tgcagA/Tggctc 5 -- int112Minor allele frequency- T:0.35NA WA CSA EA 377
    rs29700791,2
    C,F,A,H--81042559(-) actggC/Gattac 5 -- int17Minor allele frequency- G:0.31NA WA 16
    rs29111541,2
    C,A,H--81042599(+) ttgagA/Cttggg 5 -- int110Minor allele frequency- C:0.00NA WA CSA 18
    rs1136558211,2
    C,F--81042704(+) ATACTC/TGGGAG 5 -- int11Minor allele frequency- T:0.50NA 2
    rs560777631,2
    C,F--81042758(+) AGGAGG/ACTGCA 5 -- int14Minor allele frequency- A:0.12WA CSA EA 242
    rs1387698541,2
    --81042813(+) CAAGAC/TTCCGT 5 -- int10--------
    rs735933971,2
    C,F--81042844(+) AATTAG/ACAGTG 5 -- int12Minor allele frequency- A:0.04WA 120
    rs1907109471,2
    --81042880(+) GGGTGC/GTCAGG 5 -- int10--------
    rs1438280711,2
    C--81042922(+) ACCAG-/AATTGCA 5 -- int10--------
    rs1829031881,2
    --81042940(+) CACTGG/TAGAGA 5 -- int10--------

    HapMap Linkage Disequilibrium report for CENPN (81040103 - 81066719 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CENPN:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422360CNV Duplication17116639
    nsv1897CNV Loss18451855
    nsv522168CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611509    OMIM disorders: --


    Find genes that share disorders with CENPN           About GenesLikeMe

    Genetic Association Database (GAD): CENPN

    Export disorders for CENPN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CENPN gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with CENPN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)1, 2, 3 Foltz D.R....Cleveland D.W. (Nat. Cell Biol. 2006)
    2. Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N. (PubMed id 19543270)1, 2 Carroll C.W.... Straight A.F. (Nat. Cell Biol. 2009)
    3. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PubMed id 16622420)1, 2 Okada M.... Fukagawa T. (Nat. Cell Biol. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PubMed id 16716197)1, 2 Izuta H.... Yoda K. (Genes Cells 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint. (PubMed id 22426531)1 Matson D.R....Burke D.J. (amp 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55839 HGNC: 30873 AceView: BM039 Ensembl:ENSG00000166451 euGenes: HUgn55839
    ECgene: CENPN H-InvDB: CENPN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CENPN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CENPN gene:
    Search GeneIP for patents involving CENPN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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