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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CENPM Gene

protein-coding   GIFtS: 54
GCID: GC22M042334

Centromere Protein M

(Previous name: chromosome 22 open reading frame 18)
(Previous symbol: C22orf18)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Centromere Protein M1 2     CENP-M2 3
C22orf181 2 3 5     Chromosome 22 Open Reading Frame 181
PANE12 3 5     bK250D10.22
Interphase Centromere Complex Protein 392 3     Proliferation Associated Nuclear Element 12
Proliferation-Associated Nuclear Element Protein 12 3     ICEN393

External Ids:    HGNC: 183521   Entrez Gene: 790192   Ensembl: ENSG000001001627   OMIM: 6101525   UniProtKB: Q9NSP43   

Export aliases for CENPM gene to outside databases

Previous GC identifers: GC22M040664 GC22M025300


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CENPM Gene:
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on
which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized
by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128).
CENPM is an additional factor required for centromere assembly (Foltz et al., 2006 (PubMed 16622419)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for CENPM Gene: 
CENPM (centromere protein M) is a protein-coding gene. Diseases associated with CENPM include chronic lymphocytic leukemia, and leukemia, and among its related super-pathways are Mitotic Anaphase and Mitotic Prometaphase.

UniProtKB/Swiss-Prot: CENPM_HUMAN, Q9NSP4
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in
assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits
the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into
centromeres

Gene Wiki entry for CENPM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CENPM gene promoter:
         AP-1   ATF-2   HSF1 (long)   HSF1short   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCENPM promoter sequence
   Search SABiosciences Chromatin IP Primers for CENPM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

CENPM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPM gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M042334:  view genomic region     (about GC identifiers)

Start:
42,334,725 bp from pter      End:
42,343,168 bp from pter
Size:
8,444 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CENPM_HUMAN, Q9NSP4 (See protein sequence)
Recommended Name: Centromere protein M  
Size: 180 amino acids; 19737 Da
Subunit: Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and
MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO,
CENPP, CENPQ, CENPR and CENPS
Subcellular location: Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Nuclear in non-confluent cells
and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of
centromeres
Secondary accessions: A7LM22 B1AHQ9 Q6I9W3
Alternative splicing: 4 isoforms:  Q9NSP4-1   Q9NSP4-2   Q9NSP4-3   Q9NSP4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CENPM: NX_Q9NSP4

Explore proteomics data for CENPM at MOPED 

CENPM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CENPM Protein Expression

REFSEQ proteins (3 alternative transcripts): 
NP_001002876.1  NP_001103685.1  NP_076958.1  

ENSEMBL proteins: 
 ENSP00000215980   ENSP00000430624   ENSP00000384814   ENSP00000384731   ENSP00000384743  
 ENSP00000384132  
Reactome Protein details: Q9NSP4
Human Recombinant Protein Products for CENPM: 
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Cloud-Clone Corp. Proteins for CENPM 

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000777condensed chromosome kinetochore IEA--
GO:0005634nucleus IEA--
GO:0005829cytosol TAS--

CENPM for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for CENPM


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR020987 Centromere_Cenp-M

Graphical View of Domain Structure for InterPro Entry Q9NSP4

ProtoNet protein and cluster: Q9NSP4


CENPM for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CENPM_HUMAN, Q9NSP4
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in
assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits
the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into
centromeres

Phenotypes:
     1 GenomeRNAi human phenotype for CENPM:

 Decreased circadian period len 

Animal Models:
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miRNA
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Inhib. RNA
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Gene Editing
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Clone
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CENPM About                                                                                                See pathways by source

SuperPathContained pathways About
1M Phase
Mitotic Anaphase0.94
M Phase0.88
Separation of Sister Chromatids0.94
Mitotic M-M/G1 phases0.88
Mitotic Metaphase and Anaphase0.94
2Resolution of Sister Chromatid Cohesion
Resolution of Sister Chromatid Cohesion0.93
Mitotic Prometaphase0.93
3Cell Cycle
Cell Cycle, Mitotic0.84
Cell Cycle0.84

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



5/9        Reactome Pathways for CENPM (see all 9)
    Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Resolution of Sister Chromatid Cohesion
Mitotic Anaphase
Cell Cycle



CENPM for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CENPM

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/68 Interacting proteins for CENPM (Q9NSP43 ENSP000002159804) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
InteractantInteraction Details
GeneCardExternal ID(s)
CENPAP494503, ENSP000003368684I2D: score=1 STRING: ENSP00000336868
AHCTF1ENSP000003757054STRING: ENSP00000375705
AURKBENSP000003139504STRING: ENSP00000313950
BIRC5ENSP000003016334STRING: ENSP00000301633
BUB1ENSP000003025304STRING: ENSP00000302530
About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000278mitotic cell cycle TAS--

CENPM for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CENPM

Search CenterWatch for drugs/clinical trials and news about CENPM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CENPM gene (3 alternative transcripts): 
NM_001002876.1  NM_001110215.1  NM_024053.3  

Unigene Cluster for CENPM:

Centromere protein M
Hs.208912  [show with all ESTs]
Unigene Representative Sequence: AK123479
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000215980(uc003bbn.3 uc003bbo.3) ENST00000472374(uc010gyq.3)
ENST00000404067 ENST00000402338 ENST00000407253 ENST00000402420 ENST00000396437(uc003bbp.1)
ENST00000460824
miRNA
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Inhib. RNA
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Additional mRNA sequence: 

AK123479.1 AL160131.1 BC000705.2 BC007495.2 CR456399.1 CR457392.1 EU035297.1 

9 DOTS entries:

DT.210590  DT.100782520  DT.100782522  DT.95290054  DT.100782524  DT.101979497  DT.100782526  DT.100782525 
DT.100681270 

24/181 AceView cDNA sequences (see all 181):

BC000705 CR604562 BE797487 BF000589 BM451099 CA414668 BM468525 AL160131 
CR613838 BQ880613 BQ056829 NM_024053 AI609359 BE893317 BC007495 AA721489 
AI652656 BM461714 BM045658 NM_001002876 BU188205 BQ652721 BM550851 CR456399 

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CENPM (see all 7)    About this scheme

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1:              -     -                 -           -           -                     
SP2:              -     -                 -           -     -     -                     
SP3:                                      -           -           -                     
SP4:              -     -                 -                                             
SP5:                                                  -                                 


ECgene alternative splicing isoforms for CENPM

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CENPM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCTTCGTGCT
CENPM Expression
About this image


See CENPM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CENPM

SOURCE GeneReport for Unigene cluster: Hs.208912

UniProtKB/Swiss-Prot: CENPM_HUMAN, Q9NSP4
Tissue specificity: Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary.
Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells
and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly
in resting CD19 B-cells

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CENPM gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cenpm1 , 5 centromere protein M1, 5 82.41(n)1
79.44(a)1
  15 (38.56 cM)5
665701  NM_025639.41  NP_079915.11 
 822337795 
chicken
(Gallus gallus)
Aves CENPM1 centromere protein M 65.13(n)
58.62(a)
  417982  NM_001044638.1  NP_001038103.1 
lizard
(Anolis carolinensis)
Reptilia CENPM6
--
--
53(a)
53(a)
many → 1
many → 1
GL343327.1(1140561-1140809)
5(26969088-26980107)
zebrafish
(Danio rerio)
Actinopterygii pane11 proliferation associated nuclear element 53.07(n)
42.46(a)
  402852  NM_205590.2  NP_991153.2 


ENSEMBL Gene Tree for CENPM (if available)
TreeFam Gene Tree for CENPM (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/263 SNPs in CENPM are shown (see all 263)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs110900641,2
A--42334392(+) tgaggG/Tggagt 3 -- ds5001 int10--------
rs1825947991,2
C--42334458(+) TCCGCA/CTCCCG 3 -- ds5001 int10--------
rs1179625601,2
C,F--42334588(+) GGTCTC/TGAATT 3 -- ds5001 int11Minor allele frequency- T:0.13NA 120
rs1876439831,2
--42334612(+) GATCCA/GCCCAC 3 -- ds5001 int10--------
rs81358041,2
C,F,H--42334660(+) ctctgC/Tacctg 3 -- ds5001 int115Minor allele frequency- T:0.15NS EA NA WA CSA 1978
rs1469552541,2
C--42334660(+) CTCTG-/CACCTG 3 -- ds5001 int10--------
rs60025471,2
C,F--42334748(+) ATTTTT/AAAACT 3 -- ut311Minor allele frequency- A:0.38WA 118
rs10479971,2
C,F,A--42334953(-) AGCCCG/CCCGTG 3 -- ut318Minor allele frequency- C:0.29MN NA WA CSA EA 551
rs1380556021,2
C,F--42335147(+) GCACAG/AATCTG 5 /I syn1 ut311Minor allele frequency- A:0.00NA 4386
rs1842533201,2
--42335201(+) TCCACC/TTGCGG 3 -- spa10--------

HapMap Linkage Disequilibrium report for CENPM (42334725 - 42343168 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for CENPM:    About this table     
Variant IDTypeSubtypePubMed ID
esv1711771CNV Insertion17803354
esv2543828CNV Insertion19546169
nsv508736CNV Insertion20534489
dgv4979n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 610152    OMIM disorders: --

3 diseases for CENPM:    About MalaCards
chronic lymphocytic leukemia    leukemia    prostatitis


CENPM for disorders           About GeneDecksing

Genetic Association Database (GAD): CENPM
Human Genome Epidemiology (HuGE) Navigator: CENPM (1 document)

Export disorders for CENPM gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CENPM gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with CENPM)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)1, 2, 3 Foltz D.R....Cleveland D.W. (2006)
  2. The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL. (PubMed id 16391015)1, 2, 9 Brickner A.G.... Warren E.H. (2006)
  3. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)
  4. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PubMed id 16622420)1, 3 Okada M....Fukagawa T. (2006)
  5. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PubMed id 16716197)1, 2 Izuta H.... Yoda K. (2006)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
  9. The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells. (PubMed id 15183305)1, 2 Bierie B.... Hennighausen L. (2004)
  10. Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (2003)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79019 HGNC: 18352 AceView: C22orf18 Ensembl:ENSG00000100162 euGenes: HUgn79019
ECgene: CENPM H-InvDB: CENPM

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CENPM Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
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Patent Information for CENPM gene:
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