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Aliases for CENPM Gene

Aliases for CENPM Gene

  • Centromere Protein M 2 3 5
  • Proliferation-Associated Nuclear Element Protein 1 3 4
  • Interphase Centromere Complex Protein 39 3 4
  • C22orf18 3 4
  • CENP-M 3 4
  • PANE1 3 4
  • Chromosome 22 Open Reading Frame 18 2
  • ICEN39 4

External Ids for CENPM Gene

Previous HGNC Symbols for CENPM Gene

  • C22orf18

Previous GeneCards Identifiers for CENPM Gene

  • GC22M040664
  • GC22M042334
  • GC22M025300

Summaries for CENPM Gene

Entrez Gene Summary for CENPM Gene

  • The protein encoded by this gene is an inner protein of the kinetochore, the multi-protein complex that binds spindle microtubules to regulate chromosome segregation during cell division. It belongs to the constitutive centromere-associated network protein group, whose members interact with outer kinetochore proteins and help to maintain centromere identity at each cell division cycle. The protein is structurally related to GTPases but cannot bind guanosine triphosphate. A point mutation that affects interaction with another constitutive centromere-associated network protein, CENP-I, impairs kinetochore assembly and chromosome alignment, suggesting that it is required for kinetochore formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for CENPM Gene

CENPM (Centromere Protein M) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by Rho GTPases.

UniProtKB/Swiss-Prot for CENPM Gene

  • Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.

Gene Wiki entry for CENPM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPM Gene

Genomics for CENPM Gene

Regulatory Elements for CENPM Gene

Enhancers for CENPM Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CENPM on UCSC Golden Path with GeneCards custom track

Promoters for CENPM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CENPM on UCSC Golden Path with GeneCards custom track

Genomic Location for CENPM Gene

41,927,763 bp from pter
41,947,164 bp from pter
19,402 bases
Minus strand

Genomic View for CENPM Gene

Genes around CENPM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPM Gene

Proteins for CENPM Gene

  • Protein details for CENPM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Centromere protein M
    Protein Accession:
    Secondary Accessions:
    • A7LM22
    • B1AHQ9
    • Q6I9W3

    Protein attributes for CENPM Gene

    180 amino acids
    Molecular mass:
    19737 Da
    Quaternary structure:
    • Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.

    Three dimensional structures from OCA and Proteopedia for CENPM Gene

    Alternative splice isoforms for CENPM Gene


neXtProt entry for CENPM Gene

Proteomics data for CENPM Gene at MOPED

Post-translational modifications for CENPM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CENPM Gene

Domains & Families for CENPM Gene

Gene Families for CENPM Gene

Protein Domains for CENPM Gene


Suggested Antigen Peptide Sequences for CENPM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CENPM: view

No data available for UniProtKB/Swiss-Prot for CENPM Gene

Function for CENPM Gene

Molecular function for CENPM Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.
genes like me logo Genes that share phenotypes with CENPM: view

Animal Model Products

miRNA for CENPM Gene

miRTarBase miRNAs that target CENPM

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPM Gene

Localization for CENPM Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPM Gene

Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Nuclear in non-confluent cells and cytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for CENPM Gene COMPARTMENTS Subcellular localization image for CENPM gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 2
golgi apparatus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CENPM Gene

Pathways & Interactions for CENPM Gene

genes like me logo Genes that share pathways with CENPM: view

Gene Ontology (GO) - Biological Process for CENPM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with CENPM: view

No data available for SIGNOR curated interactions for CENPM Gene

Drugs & Compounds for CENPM Gene

No Compound Related Data Available

Transcripts for CENPM Gene

Unigene Clusters for CENPM Gene

Centromere protein M:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CENPM Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: -
SP6: - - - -

Relevant External Links for CENPM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CENPM Gene

mRNA expression in normal human tissues for CENPM Gene

Protein differential expression in normal tissues from HIPED for CENPM Gene

This gene is overexpressed in Fetal ovary (24.8), Fetal heart (23.3), and Fetal gut (20.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPM Gene

SOURCE GeneReport for Unigene cluster for CENPM Gene Hs.208912

mRNA Expression by UniProt/SwissProt for CENPM Gene

Tissue specificity: Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3 is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weakly expressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19 B-cells.
genes like me logo Genes that share expression patterns with CENPM: view

Protein tissue co-expression partners for CENPM Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CENPM Gene

Orthologs for CENPM Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPM Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CENPM 35
  • 85.93 (n)
  • 87.22 (a)
  • 87 (a)
(Canis familiaris)
Mammalia CENPM 35
  • 87.78 (n)
  • 87.22 (a)
  • 87 (a)
(Mus musculus)
Mammalia Cenpm 35
  • 82.41 (n)
  • 79.44 (a)
Cenpm 16
Cenpm 36
  • 79 (a)
(Pan troglodytes)
Mammalia CENPM 35
  • 99.63 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Cenpm 35
  • 83.52 (n)
  • 80.56 (a)
(Monodelphis domestica)
Mammalia CENPM 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia CENPM 36
  • 59 (a)
(Gallus gallus)
Aves CENPM 35
  • 65.62 (n)
  • 59.37 (a)
  • 58 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
-- 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpm 35
  • 58.54 (n)
  • 51.25 (a)
(Danio rerio)
Actinopterygii pane1 35
  • 53.8 (n)
  • 43.67 (a)
pane1 36
  • 41 (a)
Species with no ortholog for CENPM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPM Gene

Gene Tree for CENPM (if available)
Gene Tree for CENPM (if available)

Paralogs for CENPM Gene

No data available for Paralogs for CENPM Gene

Variants for CENPM Gene

Sequence variations from dbSNP and Humsavar for CENPM Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs7288143 -- 41,944,213(+) CAGGC(A/G)GATAC intron-variant
rs7293091 -- 41,945,304(+) TGGAG(A/G)CTGGG reference, synonymous-codon, missense
rs8135804 -- 41,938,656(+) ctctg(C/T)acctg intron-variant, downstream-variant-500B
rs8137106 -- 41,949,138(+) tactc(A/G)ggagg upstream-variant-2KB
rs34388835 -- 41,941,783(+) GGCTC(-/A)AAAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CENPM Gene

Variant ID Type Subtype PubMed ID
nsv508736 CNV Insertion 20534489
dgv4979n71 CNV Loss 21882294
esv2543828 CNV Insertion 19546169
esv1711771 CNV Insertion 17803354

Variation tolerance for CENPM Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.87; 18.08% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CENPM Gene

Disorders for CENPM Gene

Relevant External Links for CENPM

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CENPM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPM Gene

Publications for CENPM Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 2 3 4 67
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 2 3
  3. The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL. (PMID: 16391015) Brickner A.G. … Warren E.H. (Blood 2006) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for CENPM Gene

Sources for CENPM Gene