CENPM Gene
protein-coding GIFtS: 51
GCID: GC22M042334
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centromere protein M(Previous name: chromosome 22 open reading frame 18 )
(Previous symbol: C22orf18)
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Aliases
for CENPM gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Centromere Protein M1 2 | | MGC8611 | | C22orf181 2 3 5 | | Pane11 | | CENP-M1 2 3 | | Chromosome 22 Open Reading Frame 181 | | PANE12 3 5 | | BK250D10.21 | | Interphase Centromere Complex Protein 392 3 | | Proliferation Associated Nuclear Element 12 | | Proliferation-Associated Nuclear Element Protein 12 3 | | ICEN393 |
Export aliases for CENPM gene to outside databasesPrevious GC identifers: GC22M040664 GC22M025300 |
Summaries
for CENPM gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CENPM:
The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on whichthe transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by thepresence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPM is anadditional factor required for centromere assembly (Foltz et al., 2006 (PubMed 16622419)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: CENPM_HUMAN, Q9NSP4Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assemblyof kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD(nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres
Gene Wiki entry for CENPM
|
Genomic Views
for CENPM gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CENPM gene promoter:
AP-1 ATF-2 HSF1 (long) HSF1short c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for CENPM
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPM |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.2 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2CENPM Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M042334: view genomic region
(about GC identifiers)
Start:
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42,334,725 bp from pter |
End:
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42,343,168 bp from pter |
Size:
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8,444 bases |
Orientation:
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minus strand |
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Proteins
for CENPM gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CENPM_HUMAN, Q9NSP4 (See
protein sequence)Recommended Name: Centromere protein M Size: 180 amino acids; 19737 Da
Subunit: Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT andMLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO,CENPP, CENPQ, CENPR and CENPS
Subcellular location: Nucleus. Cytoplasm. Chromosome, centromere, kinetochore. Note=Nuclear in non-confluent cells andcytoplasmic in confluent or dividing cells (By similarity). Localizes in the kinetochore domain of centromeres
Secondary accessions: A7LM22 B1AHQ9 Q6I9W3Alternative splicing: 4 isoforms: Q9NSP4-1 Q9NSP4-2 Q9NSP4-3 Q9NSP4-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CENPM: NX_Q9NSP4
CENPM Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001002876.1 NP_001103685.1 NP_076958.1
ENSEMBL proteins: ENSP00000215980 ENSP00000430624 ENSP00000384814 ENSP00000384731 ENSP00000384743 ENSP00000384132 Reactome Protein details: Q9NSP4
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CENPM for ontologies About GeneDecksing
CENPM Antibody Products:
Assay Products for CENPM: |
Protein
Domains /
Families
for CENPM gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CENPM for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NSP4ProtoNet protein and cluster: Q9NSP4 |
Function
for CENPM gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CENPM_HUMAN, Q9NSP4Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assemblyof kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD(nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CENPM (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CENPM (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CENPM | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPM |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPM |
1 GenomeRNAi human phenotype for CENPM:
|
Pathways & Interactions
for CENPM gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | M Phase | | | 2 | Resolution of Sister Chromatid Cohesion | | | 3 | Cell Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/10 
Reactome Pathways for CENPM (see all 10)
CENPM for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CENPM
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/68 Interacting proteins for CENPM (Q9NSP43 ENSP000002159804) via UniProtKB, MINT, STRING, and/or I2D (see all 68)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000087 | M phase of mitotic cell cycle |
TAS | -- | | GO:0000236 | mitotic prometaphase |
TAS | -- | | GO:0000278 | mitotic cell cycle |
TAS | -- |
CENPM for ontologies About GeneDecksing
|
Drugs & Compounds
for CENPM gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CENPM
Search CenterWatch for drugs/clinical trials and news about CENPM
|
Transcripts
for CENPM gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CENPM gene (3 alternative transcripts): NM_001002876.1 NM_001110215.1 NM_024053.3 Unigene Cluster for CENPM: Centromere protein M Hs.208912 [show with all ESTs]Unigene Representative Sequence: AK1234798 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000215980(uc003bbn.3 uc003bbo.3) ENST00000472374(uc010gyq.3)
ENST00000404067 ENST00000402338 ENST00000407253 ENST00000402420 ENST00000396437(uc003bbp.1)
ENST00000460824
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CENPM (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CENPM (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): CENPM (NM_024053) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CENPM | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPM |
Additional cDNA sequence: AK123479.1 AL160131.1 BC000705.2 BC007495.2 CR456399.1 CR457392.1 EU035297.1 9 DOTS entries: DT.210590 DT.100782520 DT.100782522 DT.95290054 DT.100782524 DT.101979497 DT.100782526 DT.100782525 DT.100681270 24/181 AceView cDNA sequences (see all 181): CR620369 BE893317 BC007495 CR617812 BQ652721 BM045658 BM451099 NM_024053 AA721489 BQ056829 CR456399 BC000705 CA414668 BM550851 AI609359 NM_001002876 BF000589 AL160131 CR613838 AI867347 BE793850 BI861387 BI858246 CR604562
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CENPM (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|
|
| SP1: | | | | | - | | - | | | | | | - | | | | - | | | | - | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | - | | | | - | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for CENPM
|
Expression
for CENPM gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CENPM expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTCGTGCT
About this image
See CENPM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CENPM
SOURCE GeneReport for Unigene cluster: Hs.208912
UniProtKB/Swiss-Prot: CENPM_HUMAN, Q9NSP4Tissue specificity: Isoform 3 is highly expressed in spleen, and intermediately in heart, prostate and ovary. Isoform 3is highly expressed in resting CD19 B-cells and B-lineage chronic lymphocytic leukemia (B-CLL) cells and weaklyexpressed in activated B-cells. Isoform 1 is selectively expressed in activated CD19 cells and weakly in resting CD19B-cells
SABiosciences Custom PCR Arrays for CENPM
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CENPM
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPM |
Orthologs
for CENPM gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CENPM gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for CENPM (if available)
TreeFam Gene Tree for CENPM (if available) |
Paralogs
for CENPM gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CENPM gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CENPM (42334725 - 42343168 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CENPM
1 Indel: 103179 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CENPM |
|
Disorders
/ Diseases
for CENPM gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CENPM for disorders About GeneDecksing
OMIM gene information: 610152
OMIM disorders: --
4  diseases for CENPM: About MalaCardschronic lymphocytic leukemia lymphocytic leukemia leukemia prostatitis
Human Genome Epidemiology (HuGE) Navigator: CENPM (1 document)
Export disorders for CENPM gene to outside databases
|
Publications
for CENPM gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CENPM gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with CENPM) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)1, 2, 3 Foltz D.R....Cleveland D.W. (2006)
- The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL. (PubMed id 16391015)1, 2, 9 Brickner A.G.... Warren E.H. (2006)
- The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PubMed id 16622420)1, 3 Okada M....Fukagawa T. (2006)
- Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PubMed id 16716197)1, 2 Izuta H.... Yoda K. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells. (PubMed id 15183305)1, 2 Bierie B.... Hennighausen L. (2004)
- Reevaluating human gene annotation: a second-generation analysis of chromosome 22. (PubMed id 12529303)1, 2 Collins J.E.... Dunham I. (2003)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
|
External Searches for CENPM gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CENPM gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CENPM gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CENPM gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CENPM | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CENPM gene:
Search GeneIP for patents involving CENPM
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CENPM gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CENPM | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CENPM | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPM | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CENPM | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CENPM | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CENPM |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPM |
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