CENPL Gene
protein-coding GIFtS: 49
GCID: GC01M173768
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centromere protein L(Previous name: chromosome 1 open reading frame 155 )
(Previous symbol: C1orf155)
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Aliases
for CENPL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Centromere Protein L1 2 | | FLJ310441 | | C1orf1551 2 3 | | Chromosome 1 Open Reading Frame 1551 | | DJ383J4.31 | | RP3-383J4.12 | | Interphase Centromere Complex Protein 332 3 | | ICEN333 | | CENP-L2 3 | | |
Export aliases for CENPL gene to outside databasesPrevious GC identifers: GC01M172035 GC01M144993 |
Summaries
for CENPL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CENPL:
CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006)(PubMed 16622420).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: CENPL_HUMAN, Q8N0S6Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involvedin assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporationof newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex
Gene Wiki entry for CENPL
|
Genomic Views
for CENPL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CENPL gene promoter:
Max1 AML1a MyoD RelA NF-kappaB GATA-6 POU2F1 NF-kappaB1 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for CENPL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q25.1 Ensembl cytogenetic band: 1q25.1 HGNC cytogenetic band: 1q25.1CENPL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M173768: view genomic region
(about GC identifiers)
Start:
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173,768,688 bp from pter |
End:
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173,793,858 bp from pter |
Size:
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25,171 bases |
Orientation:
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minus strand |
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Proteins
for CENPL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CENPL_HUMAN, Q8N0S6 (See
protein sequence)Recommended Name: Centromere protein L Size: 344 amino acids; 38998 Da
Subunit: Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. TheCENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPTand MLF1IP/CENPU
Subcellular location: Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CADcomplex is probably recruited on centromeres by the CENPA-NAC complex
Secondary accessions: Q5TEL5 Q96ND4Alternative splicing: 3 isoforms: Q8N0S6-1 Q8N0S6-2 Q8N0S6-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CENPL: NX_Q8N0S6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N0S6
CENPL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001120653.1 NP_001164653.1 NP_201576.1
ENSEMBL proteins: ENSP00000348527 ENSP00000323543 ENSP00000356683 Reactome Protein details: Q8N0S6
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CENPL for ontologies About GeneDecksing
CENPL Antibody Products:
Assay Products for CENPL: |
Protein
Domains /
Families
for CENPL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CENPL for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N0S6ProtoNet protein and cluster: Q8N0S6 |
Function
for CENPL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CENPL_HUMAN, Q8N0S6Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involvedin assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporationof newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CENPL (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CENPL (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CENPL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPL |
1 GenomeRNAi human phenotype for CENPL:
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Pathways & Interactions
for CENPL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | M Phase | | | 2 | Resolution of Sister Chromatid Cohesion | | | 3 | Cell Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/10 
Reactome Pathways for CENPL (see all 10)
CENPL for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CENPL
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/70 Interacting proteins for CENPL (ENSP000003485274) via UniProtKB, MINT, STRING, and/or I2D (see all 70)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0000087 | M phase of mitotic cell cycle |
TAS | -- | | GO:0000236 | mitotic prometaphase |
TAS | -- | | GO:0000278 | mitotic cell cycle |
TAS | -- |
CENPL for ontologies About GeneDecksing
|
Drugs & Compounds
for CENPL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CENPL
Search CenterWatch for drugs/clinical trials and news about CENPL
|
Transcripts
for CENPL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CENPL gene (3 alternative transcripts): NM_001127181.2 NM_001171182.1 NM_033319.3 Unigene Cluster for CENPL: Centromere protein L Hs.720473 [show with all ESTs]Unigene Representative Sequence: NM_0011271819 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000356198(uc001gje.4 uc001gjg.4 uc001gjf.4) ENST00000345664
ENST00000367710 ENST00000496683 ENST00000460816 ENST00000484920 ENST00000479159
ENST00000493233 ENST00000495275
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CENPL (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CENPL (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): CENPL (NM_033319) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CENPL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPL |
Additional cDNA sequence: AK056348.1 BC007071.1 BC019022.2 BC033154.1 BC066658.1 9 DOTS entries: DT.95272513 DT.313079 DT.95366867 DT.308318 DT.95366870 DT.121423416 DT.95203995 DT.121423412 DT.91898325 10 AceView cDNA sequences: BX108997 AA813991 AA918218 CR617320 AW291488 AA687221 BG677088 N29457 AA360930 N41481
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CENPL About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
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| SP1: | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | | | | | | |
ECgene alternative splicing isoforms for CENPL
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Expression
for CENPL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CENPL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTATGATCC
About this image
See CENPL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CENPL
SOURCE GeneReport for Unigene cluster: Hs.720473
SABiosciences Custom PCR Arrays for CENPL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CENPL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CENPL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CENPL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CENPL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPL |
Orthologs
for CENPL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CENPL gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for CENPL (if available)
TreeFam Gene Tree for CENPL (if available) |
Paralogs
for CENPL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CENPL gene
CENPL for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CENPL
PGOHUM00000240406
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Genomic Variants
for CENPL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CENPL (173768688 - 173793858 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CENPL: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CENPL |
|
Disorders
/ Diseases
for CENPL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CENPL for disorders About GeneDecksing
OMIM gene information: 611503
OMIM disorders: --
4  diseases for CENPL: About MalaCardsseckel syndrome brachydactyly cryptorchidism microcephaly
2 diseases from the University of Copenhagen DISEASES database for CENPL:Seckel syndrome Brachydactyly Export disorders for CENPL gene to outside databases
|
Publications
for CENPL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CENPL gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with CENPL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)1, 2, 3 Foltz D.R....Cleveland D.W. (2006)
- The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PubMed id 16622420)1, 3 Okada M....Fukagawa T. (2006)
- Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PubMed id 16716197)1, 2 Izuta H.... Yoda K. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for CENPL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CENPL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CENPL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CENPL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CENPL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CENPL gene:
Search GeneIP for patents involving CENPL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CENPL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CENPL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CENPL | | | OriGene Protein Over-expression Lysate for CENPL | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CENPL | | OriGene 3'-UTR Clone for CENPL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CENPL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CENPL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CENPL | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CENPL | | OriGene Custom Protein Services for CENPL | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CENPL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CENPL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CENPL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CENPL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CENPL |
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 |  |  |  | |
| | | | Search Tocris compounds for CENPL |
| |  |  |  |  | | | | |
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 | | | CENPL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPL |
|  |  |  | | | | ThermoFisher Antibodies for CENPL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPL |
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