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Aliases for CENPL Gene

Aliases for CENPL Gene

  • Centromere Protein L 2 3 5
  • Interphase Centromere Complex Protein 33 3 4
  • C1orf155 3 4
  • CENP-L 3 4
  • Chromosome 1 Open Reading Frame 155 2
  • DJ383J4.3 3
  • ICEN33 4

External Ids for CENPL Gene

Previous HGNC Symbols for CENPL Gene

  • C1orf155

Previous GeneCards Identifiers for CENPL Gene

  • GC01M172035
  • GC01M144993

Summaries for CENPL Gene

Entrez Gene Summary for CENPL Gene

  • CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]

GeneCards Summary for CENPL Gene

CENPL (Centromere Protein L) is a Protein Coding gene. Diseases associated with CENPL include Seckel Syndrome. Among its related pathways are Cell Cycle, Mitotic and Mitotic Prometaphase.

UniProtKB/Swiss-Prot for CENPL Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Gene Wiki entry for CENPL Gene

Additional gene information for CENPL Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPL Gene

Genomics for CENPL Gene

Regulatory Elements for CENPL Gene

Enhancers for CENPL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H173861 1.2 ENCODE 21.9 -42.0 -42040 10.3 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZFP41 MEF2D SSRP1 KLHL20 RC3H1 DARS2 CENPL ZBTB37 GAS5-AS1 TEX50 ANKRD45 GAS5 RNA5SP67
GH01H173409 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +414.3 414321 2.6 HDGF PKNOX1 TBL1XR1 RB1 SIN3A BATF RFX5 ZNF143 ATF7 ETV6 KLHL20 CENPL DARS2 PRDX6 ENSG00000224228 TNFSF4 GC01M173428 LOC646870
GH01H173412 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +410.4 410418 4.6 HDGF FOXA2 ATF1 TBL1XR1 BATF RAD21 ZNF766 GATA2 EGR1 ATF7 DARS2 CENPL PRDX6 KLHL20 ENSG00000224228 GC01M173428 LOC646870
GH01H173420 1.4 Ensembl ENCODE dbSUPER 11.5 +404.1 404115 0.9 HDGF ATF1 ARNT SIN3A RAD21 CHAMP1 RFX5 ZNF143 RCOR1 ATF7 PRDX6 CENPL DARS2 KLHL20 GC01M173428 LOC646870
GH01H173473 1.5 FANTOM5 ENCODE 9.7 +347.9 347899 7.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 KLHL20 GAS5 GAS5-AS1 PRDX6 DARS2 CENPL LOC100506023 LOC101928673
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CENPL on UCSC Golden Path with GeneCards custom track

Promoters for CENPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000015990 20 2601 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF207

Genomic Locations for CENPL Gene

Genomic Locations for CENPL Gene
chr1:173,799,550-173,824,720
(GRCh38/hg38)
Size:
25,171 bases
Orientation:
Minus strand
chr1:173,768,688-173,793,858
(GRCh37/hg19)

Genomic View for CENPL Gene

Genes around CENPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPL Gene

Proteins for CENPL Gene

  • Protein details for CENPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0S6-CENPL_HUMAN
    Recommended name:
    Centromere protein L
    Protein Accession:
    Q8N0S6
    Secondary Accessions:
    • Q5TEL5
    • Q96ND4

    Protein attributes for CENPL Gene

    Size:
    344 amino acids
    Molecular mass:
    38998 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.

    Alternative splice isoforms for CENPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPL Gene

Post-translational modifications for CENPL Gene

  • Ubiquitination at posLast=6363
  • Modification sites at PhosphoSitePlus

Other Protein References for CENPL Gene

No data available for DME Specific Peptides for CENPL Gene

Domains & Families for CENPL Gene

Gene Families for CENPL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CENPL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CENPL: view

No data available for UniProtKB/Swiss-Prot for CENPL Gene

Function for CENPL Gene

Molecular function for CENPL Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Gene Ontology (GO) - Molecular Function for CENPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CENPL: view
genes like me logo Genes that share phenotypes with CENPL: view

Animal Models for CENPL Gene

MGI Knock Outs for CENPL:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CENPL Gene

Localization for CENPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPL Gene

Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPL gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CENPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CENPL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CENPL Gene

Pathways & Interactions for CENPL Gene

genes like me logo Genes that share pathways with CENPL: view

Gene Ontology (GO) - Biological Process for CENPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0034080 CENP-A containing nucleosome assembly TAS --
genes like me logo Genes that share ontologies with CENPL: view

No data available for SIGNOR curated interactions for CENPL Gene

Drugs & Compounds for CENPL Gene

No Compound Related Data Available

Transcripts for CENPL Gene

Unigene Clusters for CENPL Gene

Centromere protein L:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CENPL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for CENPL Gene

GeneLoc Exon Structure for
CENPL
ECgene alternative splicing isoforms for
CENPL

Expression for CENPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CENPL Gene

Protein differential expression in normal tissues from HIPED for CENPL Gene

This gene is overexpressed in Nasal epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CENPL Gene



Protein tissue co-expression partners for CENPL Gene

NURSA nuclear receptor signaling pathways regulating expression of CENPL Gene:

CENPL

SOURCE GeneReport for Unigene cluster for CENPL Gene:

Hs.720473

Evidence on tissue expression from TISSUES for CENPL Gene

  • Eye(4.2)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with CENPL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPL Gene

Orthologs for CENPL Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPL 33 34
  • 99.4 (n)
dog
(Canis familiaris)
Mammalia CENPL 33 34
  • 91.69 (n)
cow
(Bos Taurus)
Mammalia CENPL 33 34
  • 91.09 (n)
mouse
(Mus musculus)
Mammalia Cenpl 33 16 34
  • 87.81 (n)
rat
(Rattus norvegicus)
Mammalia Cenpl 33
  • 84.5 (n)
oppossum
(Monodelphis domestica)
Mammalia CENPL 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPL 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPL 33 34
  • 64.47 (n)
lizard
(Anolis carolinensis)
Reptilia CENPL 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpl 33
  • 61.52 (n)
Str.5928 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4198 33
zebrafish
(Danio rerio)
Actinopterygii cenpl 33 34
  • 52.64 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4945 34
  • 27 (a)
OneToOne
Species where no ortholog for CENPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPL Gene

ENSEMBL:
Gene Tree for CENPL (if available)
TreeFam:
Gene Tree for CENPL (if available)

Paralogs for CENPL Gene

Pseudogenes.org Pseudogenes for CENPL Gene

genes like me logo Genes that share paralogs with CENPL: view

No data available for Paralogs for CENPL Gene

Variants for CENPL Gene

Sequence variations from dbSNP and Humsavar for CENPL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs869312918 Pathogenic 173,825,357(+) TCCAG(A/G)TGAAA upstream-variant-2KB, splice-donor-variant
rs533128814 Uncertain significance 173,824,697(+) GCGGC(A/G)ATCTG upstream-variant-2KB, utr-variant-5-prime
rs886045585 Uncertain significance 173,824,708(+) TGTTT(C/G)GGTTC upstream-variant-2KB, utr-variant-5-prime
rs1000035024 -- 173,805,825(+) TCGGA(C/G)AGCTT intron-variant
rs1000060095 -- 173,821,555(+) GTCAA(G/T)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPL Gene

Variant ID Type Subtype PubMed ID
nsv831926 CNV gain+loss 17160897

Variation tolerance for CENPL Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CENPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPL Gene

Disorders for CENPL Gene

MalaCards: The human disease database

(1) MalaCards diseases for CENPL Gene - From: DISEASES

Disorder Aliases PubMed IDs
seckel syndrome
  • bird-headed dwarfism
- elite association - COSMIC cancer census association via MalaCards
Search CENPL in MalaCards View complete list of genes associated with diseases

Relevant External Links for CENPL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPL
genes like me logo Genes that share disorders with CENPL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CENPL Gene

Publications for CENPL Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz DR … Cleveland DW (Nature cell biology 2006) 2 3 4 60
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M … Fukagawa T (Nature cell biology 2006) 2 3 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PMID: 16716197) Izuta H … Yoda K (Genes to cells : devoted to molecular & cellular mechanisms 2006) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for CENPL Gene

Sources for CENPL Gene

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