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CENPL Gene

protein-coding   GIFtS: 50
GCID: GC01M173768

Centromere Protein L

(Previous name: chromosome 1 open reading frame 155)
(Previous symbol: C1orf155)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Centromere Protein L1 2     Chromosome 1 Open Reading Frame 1551
C1orf1551 2 3     dJ383J4.32
Interphase Centromere Complex Protein 332 3     ICEN333
CENP-L2 3     

External Ids:    HGNC: 178791   Entrez Gene: 916872   Ensembl: ENSG000001203347   OMIM: 6115035   UniProtKB: Q8N0S63   
ORGUL members:         

Export aliases for CENPL gene to outside databases

Previous GC identifers: GC01M172035 GC01M144993


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CENPL Gene:
CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA
(MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et
al., 2006) (PubMed 16622420).(supplied by OMIM, Mar 2008)

GeneCards Summary for CENPL Gene:
CENPL (centromere protein L) is a protein-coding gene. Diseases associated with CENPL include seckel syndrome, and brachydactyly.

UniProtKB/Swiss-Prot: CENPL_HUMAN, Q8N0S6
Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is
involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in
incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex

Gene Wiki entry for CENPL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CENPL gene promoter:
         Max1   AML1a   MyoD   RelA   NF-kappaB   GATA-6   POU2F1   NF-kappaB1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CENPL promoter sequence
   Search Chromatin IP Primers for CENPL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CENPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1   Ensembl cytogenetic band:  1q25.1   HGNC cytogenetic band: 1q25.1

CENPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPL gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M173768:  view genomic region     (about GC identifiers)

Start:
173,768,688 bp from pter      End:
173,793,858 bp from pter
Size:
25,171 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CENPL_HUMAN, Q8N0S6 (See protein sequence)
Recommended Name: Centromere protein L  
Size: 344 amino acids; 38998 Da
Subunit: Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and
CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH,
CENPM, CENPN, CENPT and CENPU
Secondary accessions: Q5TEL5 Q96ND4
Alternative splicing: 3 isoforms:  Q8N0S6-1   Q8N0S6-2   Q8N0S6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CENPL: NX_Q8N0S6

Explore proteomics data for CENPL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys63
  • Modification sites at PhosphoSitePlus

  • See CENPL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001120653.1  NP_001164653.1  NP_201576.1  

    ENSEMBL proteins: 
     ENSP00000348527   ENSP00000323543   ENSP00000356683  
    Reactome Protein details: Q8N0S6

    CENPL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals CENPL Protein
    Novus Biologicals CENPL Lysate
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    Cloud-Clone Corp. Proteins for CENPL

    CENPL Antibody Products:

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    LSBio Antibodies in human, mouse, rat for CENPL

    CENPL Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for CENPL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR025204 CENP-L

    Graphical View of Domain Structure for InterPro Entry Q8N0S6

    ProtoNet protein and cluster: Q8N0S6


    CENPL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPL_HUMAN, Q8N0S6
    Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is
    involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in
    incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex

    Phenotypes:
         1 GenomeRNAi human phenotype for CENPL:

     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CENPL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CENPL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CENPL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CENPL

    miRNA
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    Block miRNA regulation of human, mouse, rat CENPL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CENPL (see all 10):
    hsa-miR-579 hsa-miR-1248 hsa-miR-570 hsa-miR-511 hsa-miR-3667-5p hsa-miR-629* hsa-miR-4279 hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidCENPL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CENPL
    Predesigned siRNA for gene silencing in human, mouse, rat CENPL

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): CENPL (NM_033319)
    Sino Biological Human cDNA Clone for CENPL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CENPL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPL

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CENPL_HUMAN, Q8N0S6: Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The
    CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    peroxisome2
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    CENPL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CENPL About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for CENPL
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids



    CENPL for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CENPL
    Interactions:

        Search GeneGlobe Interaction Network for CENPL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CENPL (ENSP000003485274) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AURKBENSP000003139504STRING: ENSP00000313950
    BIRC5ENSP000003016334STRING: ENSP00000301633
    BUB1ENSP000003025304STRING: ENSP00000302530
    BUB1BENSP000002875984STRING: ENSP00000287598
    BUB3ENSP000003578584STRING: ENSP00000357858
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--

    CENPL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CENPL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CENPL gene (3 alternative transcripts): 
    NM_001127181.2  NM_001171182.1  NM_033319.3  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356198(uc001gje.4 uc001gjg.4 uc001gjf.4) ENST00000345664
    ENST00000367710 ENST00000496683 ENST00000460816 ENST00000484920 ENST00000479159
    ENST00000493233 ENST00000495275
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CENPL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CENPL (see all 10):
    hsa-miR-579 hsa-miR-1248 hsa-miR-570 hsa-miR-511 hsa-miR-3667-5p hsa-miR-629* hsa-miR-4279 hsa-miR-2115
    SwitchGear 3'UTR luciferase reporter plasmidCENPL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CENPL
    Predesigned siRNA for gene silencing in human, mouse, rat CENPL
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CENPL (NM_033319)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CENPL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPL
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CENPL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CENPL
      QuantiTect SYBR Green Assays in human, mouse, rat CENPL
      QuantiFast Probe-based Assays in human, mouse, rat CENPL

    10 AceView cDNA sequences:

    AA918218 AA813991 CR617320 BX108997 N29457 AA687221 BG677088 AA360930 
    AW291488 N41481 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CENPL    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
    SP1:                                      -                     
    SP2:                                                            
    SP3:        -                                                   
    SP4:                          -           -                     


    ECgene alternative splicing isoforms for CENPL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CENPL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTATGATCC
    CENPL Expression
    About this image

    CENPL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CENPL Protein Expression
        Custom PCR Arrays for CENPL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CENPL gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenpl1 , 5 centromere protein L1, 5 87.81(n)1
    87.31(a)1
      1 (69.75 cM)5
    704541  NM_001159930.11  NP_001153402.11 
     1610707675 
    chicken
    (Gallus gallus)
    Aves CENPL1 centromere protein L 64.47(n)
    65.46(a)
      426563  NM_001006569.3  NP_001006569.2 
    lizard
    (Anolis carolinensis)
    Reptilia CENPL6
    centromere protein L
    49(a)
    1 ↔ 1
    4(71335453-71355560)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.41982 Xenopus laevis transcribed sequences 75.29(n)    CA974001.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cenpl1 centromere protein L 52.64(n)
    43.77(a)
      445401  NM_001003878.1  NP_001003878.1 


    ENSEMBL Gene Tree for CENPL (if available)
    TreeFam Gene Tree for CENPL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CENPL gene

    CENPL for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CENPL
    PGOHUM00000240406


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CENPL (see all 409)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844101271,2
    --173768230(+) CTCCTA/TGTACA 3 -- int10--------
    rs121382571,2
    C,H--173768512(+) TGAAGG/TTTAAA 3 -- int16Minor allele frequency- T:0.00NS EA NA 422
    rs789401151,2
    C,F--173768819(+) TTGCCA/GGTTCT 3 -- ut312Minor allele frequency- G:0.05WA 120
    rs168464181,2
    C,F--173768826(+) TTCTCC/GGCAGT 3 -- ut31 ese37Minor allele frequency- G:0.13NA EA WA 562
    rs94257421,2
    C,F,A--173768985(+) ACGCTG/ATATTT 3 -- ut31 ese36Minor allele frequency- A:0.36NA WA CSA 128
    rs1115765051,2
    F--173769059(+) CAGTGG/CTGCAG 3 -- ut311Minor allele frequency- C:0.50CSA 2
    rs1894322611,2
    --173769071(+) CTTGGC/GTCACT 3 -- ut310--------
    rs1929312391,2
    --173769161(+) CCCAGC/TTAATT 3 -- ut310--------
    rs1840987461,2
    --173769455(+) GGCAAC/TTCCAA 3 -- ut310--------
    rs585297811,2
    C--173769671(+) AAAAG-/AAGGAGAC 3 -- int10--------

    HapMap Linkage Disequilibrium report for CENPL (173768688 - 173793858 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CENPL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831926CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CENPL
    DNA2.0 Custom Variant and Variant Library Synthesis for CENPL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611503    OMIM disorders: --

    4 diseases for CENPL:    
    About MalaCards
    seckel syndrome    brachydactyly    cryptorchidism    microcephaly

    2 diseases from the University of Copenhagen DISEASES database for CENPL:
    Seckel syndrome     Brachydactyly

    CENPL for disorders           About GeneDecksing


    Export disorders for CENPL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CENPL gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with CENPL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)1, 2, 3 Foltz D.R....Cleveland D.W. (Nat. Cell Biol. 2006)
    2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PubMed id 16622420)1, 3 Okada M.... Fukagawa T. (Nat. Cell Biol. 2006)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PubMed id 16716197)1, 2 Izuta H.... Yoda K. (Genes Cells 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91687 HGNC: 17879 AceView: dJ383J4.3 Ensembl:ENSG00000120334 euGenes: HUgn91687
    ECgene: CENPL H-InvDB: CENPL

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CENPL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CENPL gene:
    Search GeneIP for patents involving CENPL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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