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Aliases for CENPL Gene

Aliases for CENPL Gene

  • Centromere Protein L 2 3
  • Interphase Centromere Complex Protein 33 3 4
  • C1orf155 3 4
  • CENP-L 3 4
  • Chromosome 1 Open Reading Frame 155 2
  • DJ383J4.3 3
  • ICEN33 4

External Ids for CENPL Gene

Previous Symbols for CENPL Gene

  • C1orf155

Summaries for CENPL Gene

Entrez Gene Summary for CENPL Gene

  • CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]

GeneCards Summary for CENPL Gene

CENPL (Centromere Protein L) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CENPL Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Gene Wiki entry for CENPL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPL Gene

Genomics for CENPL Gene

Genomic Location for CENPL Gene

Start:
173,799,550 bp from pter
End:
173,824,720 bp from pter
Size:
25,171 bases
Orientation:
Minus strand

Genomic View for CENPL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CENPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPL Gene

Regulatory Elements for CENPL Gene

Proteins for CENPL Gene

  • Protein details for CENPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0S6-CENPL_HUMAN
    Recommended name:
    Centromere protein L
    Protein Accession:
    Q8N0S6
    Secondary Accessions:
    • Q5TEL5
    • Q96ND4

    Protein attributes for CENPL Gene

    Size:
    344 amino acids
    Molecular mass:
    38998 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.

    Alternative splice isoforms for CENPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPL Gene

Proteomics data for CENPL Gene at MOPED

Post-translational modifications for CENPL Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys63

Other Protein References for CENPL Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CENPL Gene

Domains for CENPL Gene

Protein Domains for CENPL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CENPL: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CENPL Gene

Function for CENPL Gene

Molecular function for CENPL Gene

UniProtKB/Swiss-Prot Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Gene Ontology (GO) - Molecular Function for CENPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CENPL: view

Phenotypes for CENPL Gene

GenomeRNAi human phenotypes for CENPL:
genes like me logo Genes that share phenotypes with CENPL: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CENPL Gene

Localization for CENPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPL Gene

Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPL Gene COMPARTMENTS Subcellular localization image for CENPL gene
Compartment Confidence
nucleus 5
cytosol 4
peroxisome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CENPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CENPL: view

Pathways for CENPL Gene

genes like me logo Genes that share pathways with CENPL: view

Pathways by source for CENPL Gene

Gene Ontology (GO) - Biological Process for CENPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006334 nucleosome assembly TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0034080 CENP-A containing nucleosome assembly TAS --
genes like me logo Genes that share ontologies with CENPL: view

Transcripts for CENPL Gene

mRNA/cDNA for CENPL Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CENPL Gene

Centromere protein L:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CENPL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for CENPL Gene

GeneLoc Exon Structure for
CENPL
ECgene alternative splicing isoforms for
CENPL

Expression for CENPL Gene

mRNA expression in normal human tissues for CENPL Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPL Gene

SOURCE GeneReport for Unigene cluster for CENPL Gene Hs.720473

genes like me logo Genes that share expressions with CENPL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CENPL Gene

Orthologs for CENPL Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPL 35
  • 99.4 (n)
  • 98.72 (a)
CENPL 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CENPL 35
  • 91.09 (n)
  • 91.28 (a)
CENPL 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CENPL 35
  • 91.69 (n)
  • 92.67 (a)
CENPL 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cenpl 35
  • 87.81 (n)
  • 87.31 (a)
Cenpl 16
Cenpl 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPL 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPL 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpl 35
  • 84.5 (n)
  • 84.59 (a)
chicken
(Gallus gallus)
Aves CENPL 35
  • 64.47 (n)
  • 65.46 (a)
CENPL 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPL 36
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4198 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpl 35
  • 61.52 (n)
  • 55.98 (a)
Str.5928 35
zebrafish
(Danio rerio)
Actinopterygii cenpl 35
  • 52.64 (n)
  • 43.77 (a)
cenpl 36
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4945 36
  • 27 (a)
OneToOne
Species with no ortholog for CENPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPL Gene

ENSEMBL:
Gene Tree for CENPL (if available)
TreeFam:
Gene Tree for CENPL (if available)

Paralogs for CENPL Gene

Pseudogenes.org Pseudogenes for CENPL Gene

genes like me logo Genes that share paralogs with CENPL: view

No data available for Paralogs for CENPL Gene

Variants for CENPL Gene

Sequence variations from dbSNP and Humsavar for CENPL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs25571 -- 173,804,790(-) ATTTA(-/AA)GTTTG intron-variant
rs1135333 -- 173,820,689(-) tattt(A/G)tcatt intron-variant
rs2144708 -- 173,810,981(+) GTAGC(A/G)CTGAT intron-variant
rs4971204 -- 173,808,260(+) aataa(A/G)taagc intron-variant
rs4971205 -- 173,815,094(+) aaatg(A/G)ataaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPL Gene

Variant ID Type Subtype PubMed ID
nsv831926 CNV Gain+Loss 17160897

Relevant External Links for CENPL Gene

HapMap Linkage Disequilibrium report
CENPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPL Gene

Disorders for CENPL Gene

(2) University of Copenhagen DISEASES for CENPL Gene

genes like me logo Genes that share disorders with CENPL: view

No data available for UniProtKB/Swiss-Prot for CENPL Gene

Publications for CENPL Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 2 3 4
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 2 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PMID: 16716197) Izuta H. … Yoda K. (Genes Cells 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CENPL Gene

Sources for CENPL Gene

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