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Aliases for CENPL Gene

Aliases for CENPL Gene

  • Centromere Protein L 2 3 5
  • Interphase Centromere Complex Protein 33 3 4
  • C1orf155 3 4
  • CENP-L 3 4
  • Chromosome 1 Open Reading Frame 155 2
  • DJ383J4.3 3
  • ICEN33 4

External Ids for CENPL Gene

Previous HGNC Symbols for CENPL Gene

  • C1orf155

Previous GeneCards Identifiers for CENPL Gene

  • GC01M172035
  • GC01M144993

Summaries for CENPL Gene

Entrez Gene Summary for CENPL Gene

  • CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]

GeneCards Summary for CENPL Gene

CENPL (Centromere Protein L) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Chromosome Maintenance.

UniProtKB/Swiss-Prot for CENPL Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.

Gene Wiki entry for CENPL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPL Gene

Genomics for CENPL Gene

Regulatory Elements for CENPL Gene

Enhancers for CENPL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CENPL on UCSC Golden Path with GeneCards custom track

Promoters for CENPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CENPL on UCSC Golden Path with GeneCards custom track

Genomic Location for CENPL Gene

Chromosome:
1
Start:
173,799,550 bp from pter
End:
173,824,720 bp from pter
Size:
25,171 bases
Orientation:
Minus strand

Genomic View for CENPL Gene

Genes around CENPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPL Gene

Proteins for CENPL Gene

  • Protein details for CENPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0S6-CENPL_HUMAN
    Recommended name:
    Centromere protein L
    Protein Accession:
    Q8N0S6
    Secondary Accessions:
    • Q5TEL5
    • Q96ND4

    Protein attributes for CENPL Gene

    Size:
    344 amino acids
    Molecular mass:
    38998 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.

    Alternative splice isoforms for CENPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPL Gene

Proteomics data for CENPL Gene at MOPED

Post-translational modifications for CENPL Gene

  • Ubiquitination at Lys 63
  • Modification sites at PhosphoSitePlus

Other Protein References for CENPL Gene

No data available for DME Specific Peptides for CENPL Gene

Domains & Families for CENPL Gene

Protein Domains for CENPL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CENPL: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CENPL Gene

Function for CENPL Gene

Molecular function for CENPL Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
genes like me logo Genes that share phenotypes with CENPL: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPL Gene

Localization for CENPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPL Gene

Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPL Gene COMPARTMENTS Subcellular localization image for CENPL gene
Compartment Confidence
cytosol 5
nucleus 5
peroxisome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CENPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CENPL: view

Pathways & Interactions for CENPL Gene

genes like me logo Genes that share pathways with CENPL: view

Gene Ontology (GO) - Biological Process for CENPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006334 nucleosome assembly TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with CENPL: view

No data available for SIGNOR curated interactions for CENPL Gene

Drugs & Compounds for CENPL Gene

No Compound Related Data Available

Transcripts for CENPL Gene

mRNA/cDNA for CENPL Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CENPL Gene

Centromere protein L:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CENPL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2:
SP3: -
SP4: - -

Relevant External Links for CENPL Gene

GeneLoc Exon Structure for
CENPL
ECgene alternative splicing isoforms for
CENPL

Expression for CENPL Gene

mRNA expression in normal human tissues for CENPL Gene

Protein differential expression in normal tissues from HIPED for CENPL Gene

This gene is overexpressed in Nasal epithelium (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPL Gene



SOURCE GeneReport for Unigene cluster for CENPL Gene Hs.720473

genes like me logo Genes that share expression patterns with CENPL: view

Protein tissue co-expression partners for CENPL Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CENPL Gene

Orthologs for CENPL Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CENPL 35
  • 91.09 (n)
  • 91.28 (a)
CENPL 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CENPL 35
  • 91.69 (n)
  • 92.67 (a)
CENPL 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cenpl 35
  • 87.81 (n)
  • 87.31 (a)
Cenpl 16
Cenpl 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CENPL 35
  • 99.4 (n)
  • 98.72 (a)
CENPL 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpl 35
  • 84.5 (n)
  • 84.59 (a)
oppossum
(Monodelphis domestica)
Mammalia CENPL 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPL 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPL 35
  • 64.47 (n)
  • 65.46 (a)
CENPL 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPL 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpl 35
  • 61.52 (n)
  • 55.98 (a)
Str.5928 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4198 35
zebrafish
(Danio rerio)
Actinopterygii cenpl 35
  • 52.64 (n)
  • 43.77 (a)
cenpl 36
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4945 36
  • 27 (a)
OneToOne
Species with no ortholog for CENPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPL Gene

ENSEMBL:
Gene Tree for CENPL (if available)
TreeFam:
Gene Tree for CENPL (if available)

Paralogs for CENPL Gene

Pseudogenes.org Pseudogenes for CENPL Gene

genes like me logo Genes that share paralogs with CENPL: view

No data available for Paralogs for CENPL Gene

Variants for CENPL Gene

Sequence variations from dbSNP and Humsavar for CENPL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12086855 - 173,807,338(+) TTTGA(A/T)GTTGA reference, missense
rs25571 -- 173,804,790(-) ATTTA(-/AA)GTTTG intron-variant
rs1135333 -- 173,820,689(-) tattt(A/G)tcatt intron-variant
rs2144708 -- 173,810,981(+) GTAGC(A/G)CTGAT intron-variant
rs4971204 -- 173,808,260(+) aataa(A/G)taagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPL Gene

Variant ID Type Subtype PubMed ID
nsv831926 CNV Gain+Loss 17160897

Variation tolerance for CENPL Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CENPL Gene

HapMap Linkage Disequilibrium report
CENPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPL Gene

Disorders for CENPL Gene

Relevant External Links for CENPL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPL

No disorders were found for CENPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPL Gene

Publications for CENPL Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 2 3 4 67
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CENPL Gene

Sources for CENPL Gene

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