Aliases for CENPK Gene
External Ids for CENPK Gene
Previous GeneCards Identifiers for CENPK Gene
CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
GeneCards Summary for CENPK Gene
CENPK (Centromere Protein K) is a Protein Coding gene. Diseases associated with CENPK include vertebrobasilar insufficiency. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases.
UniProtKB/Swiss-Prot for CENPK Gene
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore.