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CENPK Gene

protein-coding   GIFtS: 52
GCID: GC05M064850

Centromere Protein K

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Centromere Protein K1 2     Leucine Zipper Protein FKSG142
Interphase Centromere Complex Protein 372 3     SoxLZ/Sox6-Binding Protein Solt2
Protein AF-5alpha2 3     ICEN373
CENP-K2 3     p333
AF5alpha2     CEMPK5
P332     SOLT5
Solt2     

External Ids:    HGNC: 294791   Entrez Gene: 641052   Ensembl: ENSG000001232197   OMIM: 6115025   UniProtKB: Q9BS163   
ORGUL members:         

Export aliases for CENPK gene to outside databases

Previous GC identifer: GC05M061769


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CENPK Gene:
CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA
(MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et
al., 2006 (PubMed 16622420)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CENPK Gene:
CENPK (centromere protein K) is a protein-coding gene. Diseases associated with CENPK include acute leukemia, and multiple myeloma.

UniProtKB/Swiss-Prot: CENPK_HUMAN, Q9BS16
Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is
involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in
incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in
coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore

Gene Wiki entry for CENPK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_034772.7  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CENPK gene promoter:
         HFH-3   AML1a   Pbx1a   HNF-1A   Arnt   FOXI1   POU2F1   POU2F1a   HNF-1   SEF-1 (1)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCENPK promoter sequence
   Search Chromatin IP Primers for CENPK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CENPK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.3   Ensembl cytogenetic band:  5q12.3   HGNC cytogenetic band: 5q12.3

CENPK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPK gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M064850:  view genomic region     (about GC identifiers)

Start:
64,813,593 bp from pter      End:
64,858,998 bp from pter
Size:
45,406 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CENPK_HUMAN, Q9BS16 (See protein sequence)
Recommended Name: Centromere protein K  
Size: 269 amino acids; 31655 Da
Subunit: Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and
CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH,
CENPM, CENPN, CENPT and CENPU. Interacts directly with CENPH
Secondary accessions: Q9H4L0

Explore the universe of human proteins at neXtProt for CENPK: NX_Q9BS16

Explore proteomics data for CENPK at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys77, Lys149
  • Modification sites at PhosphoSitePlus

  • See CENPK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001253967.1  NP_071428.2  

    ENSEMBL proteins: 
     ENSP00000422421   ENSP00000379911   ENSP00000421034   ENSP00000425686   ENSP00000424450  
     ENSP00000423308   ENSP00000422365   ENSP00000424039   ENSP00000424686   ENSP00000427648  
     ENSP00000242872  
    Reactome Protein details: Q9BS16

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR020993 Centromere_CenpK

    Graphical View of Domain Structure for InterPro Entry Q9BS16

    ProtoNet protein and cluster: Q9BS16

    UniProtKB/Swiss-Prot: CENPK_HUMAN, Q9BS16
    Similarity: Belongs to the CENPK family


    CENPK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPK_HUMAN, Q9BS16
    Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is
    involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in
    incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in
    coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CENPK for ontologies           About GeneDecksing


    Animal Models:
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    hsa-mir-215-5p (MIRT024346), hsa-mir-192-5p (MIRT026538)

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    3 qRT-PCR Assays for microRNAs that regulate CENPK:
    hsa-miR-3942-5p hsa-miR-186 hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidCENPK 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CENPK_HUMAN, Q9BS16: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes
    exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC
    complex
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--

    CENPK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CENPK About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Packaging Of Telomere Ends
    Chromosome Maintenance0.62
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    Nucleosome assembly0.59
    4Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Reactome Pathways for CENPK
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    Deposition of new CENPA-containing nucleosomes at the centromere



    CENPK for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CENPK
    Interactions:

        Search GeneGlobe Interaction Network for CENPK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CENPK (Q9BS163 ENSP000002428724) via UniProtKB, MINT, STRING, and/or I2D (see all 114)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CENPAP494503, ENSP000003368684I2D: score=1 STRING: ENSP00000336868
    PCBD2Q9H0N53, ENSP000002549084I2D: score=1 STRING: ENSP00000254908
    SOX6P357123I2D: score=2 
    AURKBENSP000003139504STRING: ENSP00000313950
    BIRC5ENSP000003016334STRING: ENSP00000301633
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006334nucleosome assembly TAS--
    GO:0034080CENP-A containing nucleosome assembly at centromere TAS--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--

    CENPK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CENPK



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CENPK gene (2 alternative transcripts): 
    NM_001267038.1  NM_022145.4  

    Unigene Cluster for CENPK:

    Centromere protein K
    Hs.529778  [show with all ESTs]
    Unigene Representative Sequence: BC008504
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514814(uc003jtu.3) ENST00000396679(uc003jts.3) ENST00000508421
    ENST00000510693 ENST00000506282 ENST00000509397 ENST00000511841 ENST00000505960
    ENST00000515497 ENST00000515873 ENST00000510768 ENST00000513951 ENST00000502997
    ENST00000510354 ENST00000504508 ENST00000508311 ENST00000242872
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate CENPK:
    hsa-miR-3942-5p hsa-miR-186 hsa-miR-892a
    SwitchGear 3'UTR luciferase reporter plasmidCENPK 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CENPK
      QuantiTect SYBR Green Assays in human, mouse, rat CENPK
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    Additional mRNA sequence: 

    AF315941.1 AY009151.1 BC005400.1 BC008504.1 

    15 DOTS entries:

    DT.310661  DT.120886160  DT.100783243  DT.120886226  DT.91761160  DT.100025665  DT.91761161  DT.100783242 
    DT.100783244  DT.120886220  DT.91761155  DT.91761157  DT.91761170  DT.91761174  DT.95313503 

    Selected AceView cDNA sequences (see all 183):

    CF528606 AA807302 BX459174 AA552978 BM970571 CR596611 AI312843 BC071654 
    NM_197941 AW302499 BQ013157 AA854015 AI697838 CR749356 AA832416 AI436670 
    BM782515 AW297206 CR593673 AV714932 CB121560 AI080760 AI819500 AA905058 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CENPK    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:                                                                  
    SP2:                                                                  
    SP3:                                -           -                     
    SP4:                                                                  


    ECgene alternative splicing isoforms for CENPK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CENPK expression in normal human tissues (normalized intensities)      CENPK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATTTTATT
    CENPK Expression
    About this image


    CENPK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
    CENPK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CENPK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529778

    UniProtKB/Swiss-Prot: CENPK_HUMAN, Q9BS16
    Tissue specificity: Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly
    expressed in lung and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CENPK gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenpk1 , 5 centromere protein K1, 5 83.96(n)1
    75.37(a)1
      13 (56.42 cM)5
    604111  NM_021790.21  NP_068562.11 
     1042289555 
    chicken
    (Gallus gallus)
    Aves CENPK1 centromere protein K 68.76(n)
    56.9(a)
      427162  NM_001044663.1  NP_001038128.1 
    lizard
    (Anolis carolinensis)
    Reptilia CENPK6
    centromere protein K
    49(a)
    1 ↔ 1
    2(10664231-10685976)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.131032 Xenopus laevis transcribed sequence with weak similarity more 73.24(n)    48048528 
    zebrafish
    (Danio rerio)
    Actinopterygii cenpk1 centromere protein K 53.07(n)
    42.11(a)
      565144  NM_001256665.1  NP_001243594.1 


    ENSEMBL Gene Tree for CENPK (if available)
    TreeFam Gene Tree for CENPK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CENPK gene
    3 SIMAP similar genes for CENPK using alignment to 8 protein entries:     CENPK_HUMAN (see all proteins):
    GLT8D2    CRCP    FAM3A

    CENPK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CENPK (see all 865)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1472679221,2
    C--64780216(+) TGTGAG/TTGATG 2 -- us2k10--------
    rs1402413871,2
    C--64813093(+) GTTTTA/CATTAG 2 -- int10--------
    rs2455511,2
    C,F,A,H--64813275(-) GGGGAA/GGATAA 2 -- int121Minor allele frequency- G:0.28NS EA NA WA CSA 2340
    rs2455501,2
    C,F,A,H--64813296(-) TTAGGG/AAACGT 2 -- int125Minor allele frequency- A:0.47EA NA NS WA CSA 2490
    rs1453016891,2
    --64813349(+) CTTCAA/CATATT 2 -- int10--------
    rs1865755841,2
    --64813378(+) TGAAGA/TAATTA 2 -- int10--------
    rs737620181,2
    C,F--64813421(+) GAAAGC/TGCTTT 2 -- int12Minor allele frequency- T:0.06WA 120
    rs1913778331,2
    --64813867(+) TATTAC/GCTCAA 2 -- ut310--------
    rs1812913841,2
    --64813872(+) CCTCAA/GTTTTA 2 -- ut310--------
    rs1380075571,2
    C--64813962(+) AAAGAC/TATTGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CENPK (64813593 - 64858998 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CENPK: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CENPK
    DNA2.0 Custom Variant and Variant Library Synthesis for CENPK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611502    OMIM disorders: --

    UniProtKB/Swiss-Prot: CENPK_HUMAN, Q9BS16
  • Note=Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation
    t(5;11)(q12;q23) with KMT2A/MLL1

  • 5 diseases for CENPK:    About MalaCards
    acute leukemia    multiple myeloma    leukemia    myeloma
    endotheliitis


    CENPK for disorders           About GeneDecksing


    Export disorders for CENPK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CENPK gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with CENPK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia. (PubMed id 8950979)1, 2, 3 Taki T.... Morishita K. (Oncogene 1996)
    2. KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates. (PubMed id 18045986)1, 2 Cheeseman I.M.... Desai A. (Mol. Biol. Cell 2008)
    3. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PubMed id 16622420)1, 2 Okada M.... Fukagawa T. (Nat. Cell Biol. 2006)
    4. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PubMed id 16716197)1, 2 Izuta H.... Yoda K. (Genes Cells 2006)
    5. The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)1, 2 Foltz D.R....Cleveland D.W. (Nat. Cell Biol. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    10. CENP-K and CENP-H may form coiled-coils in the kinetochores. (PubMed id 19381461)2 Qiu S.... He D. (Sci. China, Ser. C, Life Sci. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64105 HGNC: 29479 AceView: ADAMTS6andFKSG14andLOC345667 Ensembl:ENSG00000123219 euGenes: HUgn64105
    ECgene: CENPK H-InvDB: CENPK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CENPK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CENPK gene:
    Search GeneIP for patents involving CENPK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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