Aliases for CENPJ Gene
External Ids for CENPJ Gene
Previous HGNC Symbols for CENPJ Gene
Previous GeneCards Identifiers for CENPJ Gene
This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for CENPJ Gene
CENPJ (Centromere Protein J) is a Protein Coding gene. Diseases associated with CENPJ include seckel syndrome 4 and microcephaly 6, primary, autosomal recessive. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Organelle biogenesis and maintenance. GO annotations related to this gene include protein kinase binding and tubulin binding.
UniProtKB/Swiss-Prot for CENPJ Gene
Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome.