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Aliases for CENPI Gene

Aliases for CENPI Gene

  • Centromere Protein I 2 3
  • FSHPRH1 3 4 6
  • LRPR1 3 4 6
  • Follicle-Stimulating Hormone Primary Response Protein 3 4
  • Interphase Centromere Complex Protein 19 3 4
  • Leucine-Rich Primary Response Protein 1 3 4
  • FSH Primary Response Protein 1 3 4
  • CENP-I 3 4
  • FSH Primary Response (LRPR1, Rat) Homolog 1 2
  • FSH Primary Response (LRPR1 Homolog, Rat) 1 2
  • FSH Primary Response 1 3
  • ICEN19 4
  • Mis6 3

External Ids for CENPI Gene

Previous HGNC Symbols for CENPI Gene

  • FSHPRH1

Previous GeneCards Identifiers for CENPI Gene

  • GC0XP100241
  • GC0XP100353
  • GC0XP090157

Summaries for CENPI Gene

Entrez Gene Summary for CENPI Gene

  • The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for CENPI Gene

CENPI (Centromere Protein I) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CENPI Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.

Gene Wiki entry for CENPI Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPI Gene

Genomics for CENPI Gene

Regulatory Elements for CENPI Gene

Genomic Location for CENPI Gene

Start:
101,098,204 bp from pter
End:
101,163,681 bp from pter
Size:
65,478 bases
Orientation:
Plus strand

Genomic View for CENPI Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CENPI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPI Gene

Proteins for CENPI Gene

  • Protein details for CENPI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92674-CENPI_HUMAN
    Recommended name:
    Centromere protein I
    Protein Accession:
    Q92674
    Secondary Accessions:
    • Q5JWZ9
    • Q96ED0

    Protein attributes for CENPI Gene

    Size:
    756 amino acids
    Molecular mass:
    86720 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts with SENP6.

    Alternative splice isoforms for CENPI Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPI Gene

Proteomics data for CENPI Gene at MOPED

Post-translational modifications for CENPI Gene

  • Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation.
  • Ubiquitination at Lys270 and Lys627
  • Modification sites at PhosphoSitePlus

Other Protein References for CENPI Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CENPI Gene

Domains for CENPI Gene

Protein Domains for CENPI Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92674

UniProtKB/Swiss-Prot:

CENPI_HUMAN :
  • Q92674
Family:
  • Belongs to the mis6 family.
genes like me logo Genes that share domains with CENPI: view

No data available for Gene Families for CENPI Gene

Function for CENPI Gene

Molecular function for CENPI Gene

UniProtKB/Swiss-Prot Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.
UniProtKB/Swiss-Prot Induction: By follicle-stimulating hormone (FSH)

Gene Ontology (GO) - Molecular Function for CENPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20212317
genes like me logo Genes that share ontologies with CENPI: view
genes like me logo Genes that share phenotypes with CENPI: view

Animal Model Products

CRISPR Products

miRNA for CENPI Gene

miRTarBase miRNAs that target CENPI

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CENPI

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CENPI Gene

Localization for CENPI Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPI Gene

Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPI Gene COMPARTMENTS Subcellular localization image for CENPI gene
Compartment Confidence
nucleus 5
cytosol 4
peroxisome 2

Gene Ontology (GO) - Cellular Components for CENPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 20212317
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CENPI: view

Pathways for CENPI Gene

genes like me logo Genes that share pathways with CENPI: view

Pathways by source for CENPI Gene

Gene Ontology (GO) - Biological Process for CENPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006334 nucleosome assembly TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007548 sex differentiation TAS 8921378
GO:0034080 CENP-A containing nucleosome assembly TAS --
genes like me logo Genes that share ontologies with CENPI: view

Transcripts for CENPI Gene

mRNA/cDNA for CENPI Gene

(11) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CENPI

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CENPI

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CENPI Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1:
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for CENPI Gene

GeneLoc Exon Structure for
CENPI
ECgene alternative splicing isoforms for
CENPI

Expression for CENPI Gene

mRNA expression in normal human tissues for CENPI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPI Gene

SOURCE GeneReport for Unigene cluster for CENPI Gene Hs.348920

genes like me logo Genes that share expressions with CENPI: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CENPI Gene

Orthologs for CENPI Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CENPI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPI 35
  • 99.6 (n)
  • 99.47 (a)
CENPI 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CENPI 35
  • 89.24 (n)
  • 83.99 (a)
CENPI 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CENPI 35
  • 89.47 (n)
  • 86.27 (a)
CENPI 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cenpi 35
  • 80.91 (n)
  • 73.72 (a)
Cenpi 16
Cenpi 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPI 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPI 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpi 35
  • 81.27 (n)
  • 73.85 (a)
chicken
(Gallus gallus)
Aves CENPI 35
  • 64.8 (n)
  • 57.24 (a)
CENPI 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPI 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpi 35
  • 56.47 (n)
  • 48.6 (a)
Str.3859 35
zebrafish
(Danio rerio)
Actinopterygii cenpi 35
  • 53.89 (n)
  • 44.01 (a)
cenpi 36
  • 39 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU04131 35
  • 38.33 (n)
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToOne
Species with no ortholog for CENPI:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPI Gene

ENSEMBL:
Gene Tree for CENPI (if available)
TreeFam:
Gene Tree for CENPI (if available)

Paralogs for CENPI Gene

Pseudogenes.org Pseudogenes for CENPI Gene

genes like me logo Genes that share paralogs with CENPI: view

No data available for Paralogs for CENPI Gene

Variants for CENPI Gene

Sequence variations from dbSNP and Humsavar for CENPI Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs767461 -- 101,124,084(+) ATATA(A/G)AATCA intron-variant
rs768584 -- 101,142,573(+) CACAG(C/T)GACTG intron-variant
rs768585 -- 101,142,331(+) TTATA(A/T)AAATG intron-variant
rs1054490 -- 101,163,458(+) TGGTA(A/G)CTTCC downstream-variant-500B, utr-variant-3-prime
rs1546984 -- 101,137,110(+) GTCTC(A/G)CTATG intron-variant

Relevant External Links for CENPI Gene

HapMap Linkage Disequilibrium report
CENPI
Locus Specific Mutation Databases (LSDB)
CENPI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CENPI Gene

Disorders for CENPI Gene

Relevant External Links for CENPI

Genetic Association Database (GAD)
CENPI
genes like me logo Genes that share disorders with CENPI: view

No data available for UniProtKB/Swiss-Prot for CENPI Gene

Publications for CENPI Gene

  1. Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene. (PMID: 8921378) Roberts R.G. … Bobrow M. (Genomics 1996) 3 4 23
  2. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 2 3 4
  3. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PMID: 16716197) Izuta H. … Yoda K. (Genes Cells 2006) 3 4
  4. Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein. (PMID: 7758824) Slegtenhorst-Eegdeman K.E. … Grootegoed J.A. (Mol. Cell. Endocrinol. 1995) 3 23
  5. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 3 4

Products for CENPI Gene

Sources for CENPI Gene

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