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Aliases for CENPI Gene

Aliases for CENPI Gene

  • Centromere Protein I 2 3 5
  • Follicle-Stimulating Hormone Primary Response Protein 3 4
  • Interphase Centromere Complex Protein 19 3 4
  • Leucine-Rich Primary Response Protein 1 3 4
  • FSHPRH1 3 4
  • CENP-I 3 4
  • LRPR1 3 4
  • FSH Primary Response (LRPR1, Rat) Homolog 1 2
  • FSH Primary Response (LRPR1 Homolog, Rat) 1 2
  • FSH Primary Response Protein 1 4
  • FSH Primary Response 1 3
  • ICEN19 4

External Ids for CENPI Gene

Previous HGNC Symbols for CENPI Gene

  • FSHPRH1

Previous GeneCards Identifiers for CENPI Gene

  • GC0XP100241
  • GC0XP100353
  • GC0XP090157

Summaries for CENPI Gene

Entrez Gene Summary for CENPI Gene

  • This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal. The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. Mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jan 2016]

GeneCards Summary for CENPI Gene

CENPI (Centromere Protein I) is a Protein Coding gene. Among its related pathways are Chromosome Maintenance and Mitotic Metaphase and Anaphase.

UniProtKB/Swiss-Prot for CENPI Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.

Gene Wiki entry for CENPI Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPI Gene

Genomics for CENPI Gene

Regulatory Elements for CENPI Gene

Enhancers for CENPI Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG101097 1 ENCODE 0.7 +0.0 6 1.9 PKNOX1 ATF1 ARID4B E2F7 SIN3A YBX1 FEZF1 YY1 ZNF121 GLIS2 CENPI PIR51843
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CENPI on UCSC Golden Path with GeneCards custom track

Promoters for CENPI Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247606 141 1801 PKNOX1 ATF1 ARID4B E2F7 SIN3A YBX1 FEZF1 YY1 ZNF121 GLIS2

Genomic Location for CENPI Gene

Chromosome:
X
Start:
101,098,159 bp from pter
End:
101,163,681 bp from pter
Size:
65,523 bases
Orientation:
Plus strand

Genomic View for CENPI Gene

Genes around CENPI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPI Gene

Proteins for CENPI Gene

  • Protein details for CENPI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92674-CENPI_HUMAN
    Recommended name:
    Centromere protein I
    Protein Accession:
    Q92674
    Secondary Accessions:
    • Q5JWZ9
    • Q96ED0

    Protein attributes for CENPI Gene

    Size:
    756 amino acids
    Molecular mass:
    86720 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts with SENP6.

    Alternative splice isoforms for CENPI Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPI Gene

Post-translational modifications for CENPI Gene

  • Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation.
  • Ubiquitination at Lys270 and Lys627
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CENPI Gene

Domains & Families for CENPI Gene

Protein Domains for CENPI Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPI Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92674

UniProtKB/Swiss-Prot:

CENPI_HUMAN :
  • Belongs to the mis6 family.
Family:
  • Belongs to the mis6 family.
genes like me logo Genes that share domains with CENPI: view

No data available for Gene Families for CENPI Gene

Function for CENPI Gene

Molecular function for CENPI Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.
UniProtKB/Swiss-Prot Induction:
By follicle-stimulating hormone (FSH).

Gene Ontology (GO) - Molecular Function for CENPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20212317
genes like me logo Genes that share ontologies with CENPI: view
genes like me logo Genes that share phenotypes with CENPI: view

Animal Model Products

CRISPR Products

miRNA for CENPI Gene

miRTarBase miRNAs that target CENPI

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CENPI

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPI Gene

Localization for CENPI Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPI Gene

Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPI gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CENPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 20212317
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CENPI: view

Pathways & Interactions for CENPI Gene

genes like me logo Genes that share pathways with CENPI: view

Pathways by source for CENPI Gene

Gene Ontology (GO) - Biological Process for CENPI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0007548 sex differentiation TAS 8921378
GO:0034080 CENP-A containing nucleosome assembly TAS --
GO:0034508 centromere complex assembly IEA --
genes like me logo Genes that share ontologies with CENPI: view

No data available for SIGNOR curated interactions for CENPI Gene

Drugs & Compounds for CENPI Gene

No Compound Related Data Available

Transcripts for CENPI Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CENPI

Alternative Splicing Database (ASD) splice patterns (SP) for CENPI Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1:
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for CENPI Gene

GeneLoc Exon Structure for
CENPI
ECgene alternative splicing isoforms for
CENPI

Expression for CENPI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CENPI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CENPI Gene

This gene is overexpressed in Liver, secretome (64.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CENPI Gene



Protein tissue co-expression partners for CENPI Gene

NURSA nuclear receptor signaling pathways regulating expression of CENPI Gene:

CENPI

SOURCE GeneReport for Unigene cluster for CENPI Gene:

Hs.348920
genes like me logo Genes that share expression patterns with CENPI: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPI Gene

Orthologs for CENPI Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CENPI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPI 34 35
  • 99.6 (n)
dog
(Canis familiaris)
Mammalia CENPI 34 35
  • 89.47 (n)
cow
(Bos Taurus)
Mammalia CENPI 34 35
  • 89.24 (n)
rat
(Rattus norvegicus)
Mammalia Cenpi 34
  • 81.27 (n)
mouse
(Mus musculus)
Mammalia Cenpi 34 16 35
  • 80.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CENPI 35
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPI 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPI 34 35
  • 64.8 (n)
lizard
(Anolis carolinensis)
Reptilia CENPI 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpi 34
  • 56.47 (n)
Str.3859 34
zebrafish
(Danio rerio)
Actinopterygii cenpi 34 35
  • 53.89 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04131 34
  • 38.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToOne
Species where no ortholog for CENPI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPI Gene

ENSEMBL:
Gene Tree for CENPI (if available)
TreeFam:
Gene Tree for CENPI (if available)

Paralogs for CENPI Gene

Pseudogenes.org Pseudogenes for CENPI Gene

genes like me logo Genes that share paralogs with CENPI: view

No data available for Paralogs for CENPI Gene

Variants for CENPI Gene

Sequence variations from dbSNP and Humsavar for CENPI Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000095347 -- 101,171,489(+) TAGAG(G/T)GCAGT intron-variant
rs1000113753 -- 101,103,254(+) CTCCC(A/G)AAGTG intron-variant
rs1000123874 -- 101,169,092(+) TACAC(A/G)TACAC intron-variant
rs1000143218 -- 101,147,881(+) CCTGA(G/T)GGGAG intron-variant
rs1000146326 -- 101,171,739(+) ACTTT(C/T)AGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPI Gene

Variant ID Type Subtype PubMed ID
esv3574256 CNV loss 25503493
nsv476319 CNV novel sequence insertion 20440878

Variation tolerance for CENPI Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 24.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CENPI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPI Gene

Disorders for CENPI Gene

Relevant External Links for CENPI

Genetic Association Database (GAD)
CENPI
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPI

No disorders were found for CENPI Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPI Gene

Publications for CENPI Gene

  1. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 2 3 4 64
  2. Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene. (PMID: 8921378) Roberts R.G. … Bobrow M. (Genomics 1996) 3 4 22 64
  3. The SUMO protease SENP6 is essential for inner kinetochore assembly. (PMID: 20212317) Mukhopadhyay D. … Dasso M. (J. Cell Biol. 2010) 3 4 64
  4. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 3 4 64
  5. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PMID: 16716197) Izuta H. … Yoda K. (Genes Cells 2006) 3 4 64

Products for CENPI Gene

  • Addgene plasmids for CENPI

Sources for CENPI Gene

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