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CENPH Gene

protein-coding   GIFtS: 57
GCID: GC05P068508

Centromere Protein H

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centromere Protein H1 2
Interphase Centromere Complex Protein 352 3
CENP-H2 3
Kinetochore Protein CENP-H2
ICEN353

External Ids:    HGNC: 172681   Entrez Gene: 649462   Ensembl: ENSG000001530447   OMIM: 6056075   UniProtKB: Q9H3R53   

Export aliases for CENPH gene to outside databases

Previous GC identifers: GC05P068637 GC05P070050 GC05P068455 GC05P068502 GC05P068503 GC05P068521 GC05P068486 GC05P065440 GC05P068488 GC05P068496


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CENPH Gene:
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and
sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins
CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where
CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is
thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein
localize constitutively to the inner kinetochore plate and play an important role in the organization and
function of the active centromere-kinetochore complex. (provided by RefSeq, Jul 2008)

GeneCards Summary for CENPH Gene:
CENPH (centromere protein H) is a protein-coding gene. GO annotations related to this gene include kinetochore binding.

UniProtKB/Swiss-Prot: CENPH_HUMAN, Q9H3R5
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in
assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits
the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into
centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate

Gene Wiki entry for CENPH Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the CENPH gene promoter:
         YY1   NF-AT   PPAR-gamma1   NF-AT4   NF-AT2   E2F-1   E2F   NF-AT3   PPAR-gamma2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCENPH promoter sequence
   Search Chromatin IP Primers for CENPH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CENPH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5p15.2

CENPH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPH gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P068508:  view genomic region     (about GC identifiers)

Start:
68,485,375 bp from pter      End:
68,506,184 bp from pter
Size:
20,810 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CENPH_HUMAN, Q9H3R5 (See protein sequence)
Recommended Name: Centromere protein H  
Size: 247 amino acids; 28481 Da
Subunit: Self-associates. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM,
CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK,
CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts directly with CENPK. Interacts with KIF2C and NDC80.
Interacts with TRIM36 (By similarity)
Secondary accessions: A8K3Y1

Explore the universe of human proteins at neXtProt for CENPH: NX_Q9H3R5

Explore proteomics data for CENPH at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys76, Lys131, Lys138
  • Modification sites at PhosphoSitePlus

  • See CENPH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_075060.1  
    ENSEMBL proteins: 
     ENSP00000283006   ENSP00000426014   ENSP00000422665   ENSP00000423936  
    Reactome Protein details: Q9H3R5

    CENPH Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008426 CENP-H

    Graphical View of Domain Structure for InterPro Entry Q9H3R5

    ProtoNet protein and cluster: Q9H3R5

    UniProtKB/Swiss-Prot: CENPH_HUMAN, Q9H3R5
    Similarity: Belongs to the centromere protein H family


    Find genes that share domains with CENPH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPH_HUMAN, Q9H3R5
    Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in
    assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits
    the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into
    centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11092768
    GO:0043515kinetochore binding IDA11092768
         
    Find genes that share ontologies with CENPH           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CENPH:
     Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CENPH
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CENPH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CENPH

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    Inhib. RNA
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    Sino Biological Human cDNA Clone for CENPH
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPH

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CENPH_HUMAN, Q9H3R5: Nucleus. Chromosome, centromere, kinetochore. Note=Associates with active
    centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins
    CENPA and CENPC during both interphase and metaphase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore NAS11092768
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0005634nucleus IDA11092768
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CENPH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CENPH About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Packaging Of Telomere Ends
    Chromosome Maintenance0.62
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.59
    Nucleosome assembly0.59
    4Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92


    Find genes that share SuperPaths with CENPH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4 Reactome Pathways for CENPH
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    Deposition of new CENPA-containing nucleosomes at the centromere


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CENPH
    Interactions:

        GeneGlobe Interaction Network for CENPH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CENPH (Q9H3R51, 3 ENSP000002830064) via UniProtKB, MINT, STRING, and/or I2D (see all 84)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDC80O147771, 3, ENSP000002615974EBI-1003700,EBI-715849 I2D: score=1 STRING: ENSP00000261597
    KIF2CQ996613, ENSP000003612984I2D: score=2 STRING: ENSP00000361298
    CENPAP494503, ENSP000003368684I2D: score=1 STRING: ENSP00000336868
    EMC1Q8N7663, ENSP000004206084I2D: score=1 STRING: ENSP00000420608
    PMVKQ151263, ENSP000003574524I2D: score=2 STRING: ENSP00000357452
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006334nucleosome assembly TAS--
    GO:0034080CENP-A containing nucleosome assembly at centromere TAS--
    GO:0051382kinetochore assembly IEA--
    GO:0051383kinetochore organization TAS11092768

    Find genes that share ontologies with CENPH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CENPH



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CENPH gene: 
    NM_022909.3  

    Unigene Cluster for CENPH:

    Centromere protein H
    Hs.631967  [show with all ESTs]
    Unigene Representative Sequence: NM_022909
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283006(uc003jvp.3 uc010ixc.3) ENST00000515001 ENST00000513575
    ENST00000514753 ENST00000502689 ENST00000510742
    miRNA
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    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CENPH (NM_022909)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPH
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CENPH
      QuantiTect SYBR Green Assays in human, mouse, rat CENPH
      QuantiFast Probe-based Assays in human, mouse, rat CENPH

    Additional mRNA sequence: 

    AB035124.1 AK123761.1 AK290746.1 BC012024.1 BC015355.1 

    5 DOTS entries:

    DT.436393  DT.95265199  DT.70104003  DT.100752314  DT.102825493 

    Selected AceView cDNA sequences (see all 68):

    AA621909 BQ224410 CR591291 BU619072 BC012024 BM759142 BE048279 BM907456 
    BC015355 BU171154 CR616601 BM460410 BM475537 BU618976 BF795308 NM_022909 
    AB035124 BM468907 BQ049779 BG773549 AL539195 BQ231085 AA116064 BU685604 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CENPH    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c
    SP1:                                                  -                 -                                 
    SP2:                                            -     -                 -                                 
    SP3:                                      -           -                 -                                 
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for CENPH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CENPH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTAATAAG
    CENPH Expression
    About this image


    CENPH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
    CENPH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CENPH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631967
        Custom PCR Arrays for CENPH
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CENPH
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CENPH gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenph1 , 5 centromere protein H1, 5 76.01(n)1
    67.78(a)1
      13 (53.23 cM)5
    268861  NM_021886.11  NP_068686.11 
     1007596745 
    chicken
    (Gallus gallus)
    Aves CENPH1 centromere protein H 51.97(n)
    35.91(a)
      395316  NM_204611.1  NP_989942.1 
    lizard
    (Anolis carolinensis)
    Reptilia CENPH6
    centromere protein H
    34(a)
    1 ↔ 1
    2(12380183-12389248)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cenph1 centromere protein H 56.45(n)
    46.73(a)
      779498  XM_002934203.2  XP_002934249.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cenph6
    centromere protein H
    24(a)
    1 ↔ 1
    8(17687276-17693094) ENSDARG00000094892


    ENSEMBL Gene Tree for CENPH (if available)
    TreeFam Gene Tree for CENPH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CENPH (see all 516)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361674
    A colorectal cancer sample4--see VAR_0361672 E K mis40--------
    rs360530161,2
    C--68483561(+) TTTTTT/-GAGAC 1 -- us2k12Minor allele frequency- -:0.25NA CSA 4
    rs1475643281,2
    --68483602(+) ACCCAA/GGATGG 1 -- us2k10--------
    rs5385461,2
    H--68483656(-) acttgA/Ggcccc 1 -- us2k1 tfbs35Minor allele frequency- G:0.06NS EA MN 598
    rs583976181,2
    C,F--68483658(+) GGCCCA/TAGTGA 1 -- us2k12Minor allele frequency- T:0.18WA 120
    rs773945501,2
    --68483893(+) TGTTTG/TTTTGT 1 -- us2k10--------
    rs1129504421,2
    C--68483893(+) GTTTTTTTG/-  
            
    TTTGT
    1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1398470231,2
    C--68483894(+) TTTGT-/TTTG  
            
    TTGTT
    1 -- us2k10--------
    rs589068501,2
    C--68483896(+) TGTTTGTTT/-  
            
    TTCGA
    1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs3501151,2
    C,F,A,H--68483948(-) tgcacT/Gccagc 1 -- us2k110Minor allele frequency- G:0.38MN WA NA CSA EA 436

    HapMap Linkage Disequilibrium report for CENPH (68485375 - 68506184 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CENPH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509066CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CENPH
    DNA2.0 Custom Variant and Variant Library Synthesis for CENPH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605607    OMIM disorders: --


    Find genes that share disorders with CENPH           About GenesLikeMe

    1 Novoseek inferred disease relationship for CENPH gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 15930286 (1), 17255272 (1), 19170237 (1), 18700042 (1)

    Human Genome Epidemiology (HuGE) Navigator: CENPH (1 document)

    Export disorders for CENPH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CENPH gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with CENPH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere-kinetochore complexes. (PubMed id 11092768)1, 2, 3, 9 Sugata N.... Todokoro K. (Hum. Mol. Genet. 2000)
    2. RNAi knockdown of human kinetochore protein CENP-H. (PubMed id 16875666)1, 2, 9 Orthaus S.... Diekmann S. (Biochem. Biophys. Res. Commun. 2006)
    3. Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres. (PubMed id 17651496)1, 2, 9 Alonso A.... Warburton P.E. (Genome Biol. 2007)
    4. The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)1, 2, 9 Foltz D.R....Cleveland D.W. (Nat. Cell Biol. 2006)
    5. Transcription within a functional human centromere. (PubMed id 14536089)1, 2, 9 Saffery R.... Choo K.H.A. (Mol. Cell 2003)
    6. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PubMed id 16716197)1, 2 Izuta H.... Yoda K. (Genes Cells 2006)
    7. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PubMed id 16622420)1, 2 Okada M.... Fukagawa T. (Nat. Cell Biol. 2006)
    8. The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis. (PubMed id 15713649)1, 2 Mikami Y.... Fukagawa T. (Mol. Cell. Biol. 2005)
    9. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. (PubMed id 15502821)1, 3 Obuse C....Yanagida M. (Nat. Cell Biol. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64946 HGNC: 17268 AceView: CENPH Ensembl:ENSG00000153044 euGenes: HUgn64946
    ECgene: CENPH H-InvDB: CENPH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CENPH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CENPH gene:
    Search GeneIP for patents involving CENPH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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