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Aliases for CENPH Gene

Aliases for CENPH Gene

  • Centromere Protein H 2 3 5
  • Interphase Centromere Complex Protein 35 3 4
  • CENP-H 3 4
  • Kinetochore Protein CENP-H 3
  • ICEN35 4

External Ids for CENPH Gene

Previous GeneCards Identifiers for CENPH Gene

  • GC05P068637
  • GC05P070050
  • GC05P068455
  • GC05P068502
  • GC05P068503
  • GC05P068521
  • GC05P068486
  • GC05P065440
  • GC05P068488
  • GC05P068496
  • GC05P068508

Summaries for CENPH Gene

Entrez Gene Summary for CENPH Gene

  • Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for CENPH Gene

CENPH (Centromere Protein H) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Signaling by Rho GTPases. GO annotations related to this gene include kinetochore binding.

UniProtKB/Swiss-Prot for CENPH Gene

  • Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.

Gene Wiki entry for CENPH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPH Gene

Genomics for CENPH Gene

Regulatory Elements for CENPH Gene

Enhancers for CENPH Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CENPH on UCSC Golden Path with GeneCards custom track

Promoters for CENPH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CENPH on UCSC Golden Path with GeneCards custom track

Genomic Location for CENPH Gene

Chromosome:
5
Start:
69,189,548 bp from pter
End:
69,210,357 bp from pter
Size:
20,810 bases
Orientation:
Plus strand

Genomic View for CENPH Gene

Genes around CENPH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPH Gene

Proteins for CENPH Gene

  • Protein details for CENPH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3R5-CENPH_HUMAN
    Recommended name:
    Centromere protein H
    Protein Accession:
    Q9H3R5
    Secondary Accessions:
    • A8K3Y1

    Protein attributes for CENPH Gene

    Size:
    247 amino acids
    Molecular mass:
    28481 Da
    Quaternary structure:
    • Self-associates. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts directly with CENPK. Interacts with KIF2C and NDC80. Interacts with TRIM36 (By similarity).

neXtProt entry for CENPH Gene

Proteomics data for CENPH Gene at MOPED

Post-translational modifications for CENPH Gene

  • Ubiquitination at Lys 76, Lys 131, and Lys 138
  • Modification sites at PhosphoSitePlus

Other Protein References for CENPH Gene

No data available for DME Specific Peptides for CENPH Gene

Domains & Families for CENPH Gene

Protein Domains for CENPH Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9H3R5

UniProtKB/Swiss-Prot:

CENPH_HUMAN :
  • Belongs to the centromere protein H family.
Family:
  • Belongs to the centromere protein H family.
genes like me logo Genes that share domains with CENPH: view

No data available for Gene Families for CENPH Gene

Function for CENPH Gene

Molecular function for CENPH Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
genes like me logo Genes that share phenotypes with CENPH: view

Animal Models for CENPH Gene

MGI Knock Outs for CENPH:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CENPH Gene

Localization for CENPH Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPH Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Associates with active centromere-kinetochore complexes throughout the cell cycle. Colocalizes with inner kinetochore plate proteins CENPA and CENPC during both interphase and metaphase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPH Gene COMPARTMENTS Subcellular localization image for CENPH gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2

No data available for Gene Ontology (GO) - Cellular Components for CENPH Gene

Pathways & Interactions for CENPH Gene

genes like me logo Genes that share pathways with CENPH: view

Gene Ontology (GO) - Biological Process for CENPH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051383 kinetochore organization TAS 11092768
genes like me logo Genes that share ontologies with CENPH: view

No data available for SIGNOR curated interactions for CENPH Gene

Drugs & Compounds for CENPH Gene

No Compound Related Data Available

Transcripts for CENPH Gene

Unigene Clusters for CENPH Gene

Centromere protein H:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CENPH Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c
SP1: - -
SP2: - - -
SP3: - - -
SP4:
SP5:

Relevant External Links for CENPH Gene

GeneLoc Exon Structure for
CENPH
ECgene alternative splicing isoforms for
CENPH

Expression for CENPH Gene

mRNA expression in normal human tissues for CENPH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CENPH Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for CENPH Gene

This gene is overexpressed in Fetal ovary (20.7), Amniocyte (15.7), Testis (10.6), Islet of Langerhans (10.4), and Plasma (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPH Gene



SOURCE GeneReport for Unigene cluster for CENPH Gene Hs.631967

genes like me logo Genes that share expression patterns with CENPH: view

Protein tissue co-expression partners for CENPH Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CENPH Gene

Orthologs for CENPH Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CENPH 35
  • 88.39 (n)
  • 83.2 (a)
CENPH 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CENPH 35
  • 85.52 (n)
  • 77.37 (a)
CENPH 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cenph 35
  • 76.01 (n)
  • 67.78 (a)
Cenph 16
Cenph 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CENPH 35
  • 99.33 (n)
  • 98.79 (a)
CENPH 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC681185 35
  • 78.5 (n)
  • 76 (a)
oppossum
(Monodelphis domestica)
Mammalia CENPH 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPH 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPH 35
  • 51.97 (n)
  • 35.91 (a)
CENPH 36
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPH 36
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenph 35
  • 56.45 (n)
  • 46.73 (a)
zebrafish
(Danio rerio)
Actinopterygii cenph 36
  • 24 (a)
OneToOne
Species with no ortholog for CENPH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPH Gene

ENSEMBL:
Gene Tree for CENPH (if available)
TreeFam:
Gene Tree for CENPH (if available)

Paralogs for CENPH Gene

No data available for Paralogs for CENPH Gene

Variants for CENPH Gene

Sequence variations from dbSNP and Humsavar for CENPH Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_036167 A colorectal cancer sample
rs2637128 -- 69,208,504(+) CAGGC(A/G)TCCAC intron-variant
rs2637129 -- 69,208,549(+) AGACG(A/G)GGTTT intron-variant
rs100192 -- 69,192,347(-) TGGAA(C/T)GTAAA intron-variant
rs2930952 -- 69,196,427(+) atcac(C/T)tgagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPH Gene

Variant ID Type Subtype PubMed ID
nsv509066 CNV Insertion 20534489

Variation tolerance for CENPH Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.21% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CENPH Gene

Disorders for CENPH Gene

Relevant External Links for CENPH

Human Genome Epidemiology (HuGE) Navigator
CENPH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPH

No disorders were found for CENPH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPH Gene

Publications for CENPH Gene

  1. Human CENP-H multimers colocalize with CENP-A and CENP-C at active centromere-kinetochore complexes. (PMID: 11092768) Sugata N. … Todokoro K. (Hum. Mol. Genet. 2000) 2 3 4 23 67
  2. Centromere protein H is a novel prognostic marker for human nonsmall cell lung cancer progression and overall patient survival. (PMID: 19170237) Liao W.T. … Song L.B. (Cancer 2009) 3 23
  3. Upregulation of CENP-H in tongue cancer correlates with poor prognosis and progression. (PMID: 19500341) Liao W.T. … Li J.S. (J. Exp. Clin. Cancer Res. 2009) 3 23
  4. Prognostic relevance of Centromere protein H expression in esophageal carcinoma. (PMID: 18700042) Guo X.Z. … Zeng M.S. (BMC Cancer 2008) 3 23
  5. Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival. (PMID: 17255272) Liao W.T. … Zeng M.S. (Clin. Cancer Res. 2007) 3 23

Products for CENPH Gene

Sources for CENPH Gene

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