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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CENPF Gene

protein-coding   GIFtS: 59
GCID: GC01P214776

centromere protein F, 350/400kDa

(Previous names: centromere protein F, 350/400kDa (mitosin) )
 Explore 25 diseases affiliated with
CENPF via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CENPF    

Aliases
for CENPF gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Centromere Protein F, 350/400kDa1 2     Cell-Cycle-Dependent 350K Nuclear Protein2
Centromere Protein F, 350/400kDa (Mitosin)1 2     CENP-F Kinetochore Protein2
Hcp-11     Centromere Protein F2
Kinetochore Protein CENPF2 3     Centromere Protein F, 350/400ka (Mitosin)2
AH Antigen2 3     Mitosin3
CENF2     CENP-F3
PRO17792     Mitosin3

External Ids:    HGNC: 18571   Entrez Gene: 10632   Ensembl: ENSG000001177247   OMIM: 6002365   UniProtKB: P494543   

Export aliases for CENPF gene to outside databases

Previous GC identifers: GC01P213428 GC01P210596 GC01P211392 GC01P211833 GC01P211165 GC01P212843 GC01P185450


Summaries
for CENPF gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CENPF:
This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the
nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains
this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late
anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein
suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or
heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CENPF_HUMAN, P49454
Function: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore
localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between
recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential
inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins
during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte
cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction
with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence
cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell
differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia

Gene Wiki entry for CENPF


Genomic Views
for CENPF gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CENPF gene promoter:
         HOXA9   HOXA9B   AhR   HTF   Pax-2   Pax-2a   Meis-1b   CBF-A   Meis-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CENPF promoter sequence
   Search SABiosciences Chromatin IP Primers for CENPF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

CENPF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPF gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P214776:  view genomic region     (about GC identifiers)

Start:
 214,776,532 bp from pter      End:
 214,837,931 bp from pter
Size:
 61,400 bases      Orientation:
 plus strand

Proteins
for CENPF gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CENPF_HUMAN, P49454 (See protein sequence)
Recommended Name: Centromere protein F precursor  
Size: 3210 amino acids; 367764 Da
Subunit: Interacts with and STX4 (via C-terminus) (By similarity). Interacts (via N-terminus) with RBL1, RBL2 and
SNAP25 (By similarity). Self-associates. Interacts with CENP-E and BUBR1 (via C-terminus). Interacts (via C-terminus)
with NDE1, NDEL1 and RB1
Subcellular location: Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore. Cytoplasm,
cytoskeleton, spindle. Note=Relocalizes to the kinetochore/centromere (coronal surface of the outer plate) and the
spindle during mitosis. Observed in nucleus during interphase but not in the nucleolus. At metaphase becomes localized
to areas including kinetochore and mitotic apparatus as well as cytoplasm. By telophase, is concentrated within the
intracellular bridge at either side of the mid-body
Developmental stage: Gradually accumulates during the cell cycle, reaching peak levels in G2 and M phase, and is
rapidly degraded upon completion of mitosis
Secondary accessions: Q13171 Q13246 Q5VVM7

Explore the universe of human proteins at neXtProt for CENPF: NX_P49454

Post-translational modifications:

  • Hyperphosphorylated during mitosis1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49454

    • CENPF Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057427.3  
    ENSEMBL proteins: 
     ENSP00000355922  
    Reactome Protein details: P49454
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CENPF

    Gene Ontology (GO): 5/14 cellular component terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA11084331
    GO:0000776kinetochore IDA17363900
    GO:0000785colocalizes with chromatin NAS9891037
    GO:0000922spindle pole IDA7542657
    GO:0000940condensed chromosome outer kinetochore TAS12974617


    CENPF for ontologies           About GeneDecksing



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    Uscn Antibodies for CENPF
    ThermoFisher Antibodies for CENPF

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    Uscn ELISAs and CLIAs for CENPF

    Protein Domains /
    Families
    for CENPF gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CENPF for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR019513 Centromere_CenpF_leu-rich_rpt
     IPR018463 Centromere_CenpF_N
     IPR018302 Centromere_CenpF_Rb-prot-bd

    Graphical View of Domain Structure for InterPro Entry P49454

    ProtoNet protein and cluster: P49454

    UniProtKB/Swiss-Prot: CENPF_HUMAN, P49454
    Similarity: Belongs to the centromere protein F family


    Function
    for CENPF gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CENPF_HUMAN, P49454
    Function: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore
    localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between
    recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential
    inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins
    during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte
    cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction
    with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence
    cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell
    differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia

         Genatlas biochemistry entry for CENPF:
    centromere protein F,component of the outer kinetochore plate

    miRNA
    Products:            		miRTarBase miRNAs that target CENPF:
    hsa-mir-373 (MIRT002525)

    OriGene 3'-UTR Clone: CENPF
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CENPF
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CENPF:
    hsa-miR-205 hsa-miR-520f hsa-miR-2115 hsa-miR-510
    SwitchGear 3'UTR luciferase reporter plasmid: CENPF 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CENPF (see all 4)
    OriGene shRNA RFP: CENPF
    OriGene siRNA: CENPF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CENPF

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CENPF

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CENPF (see all 2)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPF 

    Cell Line
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    Search LifeMap BioReagents cell lines for CENPF

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPF

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding NAS9891037
    GO:0005515protein binding IPI17600710
    GO:0008022protein C-terminus binding IPI7642639
    GO:0008134transcription factor binding IPI15677469
    GO:0042803protein homodimerization activity IPI7642639


    CENPF for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CENPF:
     Decreased viability with pacli 


    Pathways & Interactions
    for CENPF gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    2Resolution of Sister Chromatid Cohesion
    		Resolution of Sister Chromatid Cohesion1.00
    		Mitotic Prometaphase0.93
    		Kinetochore assembly0.96
    3Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84
    4FOXM1 transcription factor network
    		FOXM1 transcription factor network1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for CENPF 
        FOXM1 transcription factor network

    5/10        Reactome Pathways for CENPF (see all 10)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase
    Cell Cycle



    CENPF for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CENPF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/98 Interacting proteins for CENPF (P494541, 2, 3 ENSP000003559224) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDEL1Q9GZM81, 3, ENSP000003339824EBI-2563723,EBI-2557484 I2D: score=2 STRING: ENSP00000333982
    NUP133Q8WUM02, 3, ENSP000002613964MINT-4788132 MINT-4788150 I2D: score=2 STRING: ENSP00000261396
    CENPEQ022243, ENSP000002651484I2D: score=2 STRING: ENSP00000265148
    FNTAP493543, ENSP000003034234I2D: score=2 STRING: ENSP00000303423
    FNTBP493563, ENSP000002461664I2D: score=2 STRING: ENSP00000246166
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000085G2 phase of mitotic cell cycle IMP12154071
    GO:0000087M phase of mitotic cell cycle TAS--
    GO:0000236mitotic prometaphase TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication IEA--


    CENPF for ontologies           About GeneDecksing



    Drugs & Compounds
    for CENPF gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CENPF for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CENPF
    4 Novoseek chemical compound relationships for CENPF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lonafarnib 73.8 2 17431110 (2)
    leucine 21.4 2 15677469 (2)
    paclitaxel 9.8 2 12467231 (1)
    tyrosine 0 2 11953011 (1), 14724156 (1)

    Search CenterWatch for drugs/clinical trials and news about CENPF 

    Transcripts
    for CENPF gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CENPF gene: 
    NM_016343.3  

    Unigene Cluster for CENPF:

    Centromere protein F, 350/400kDa (mitosin)
    Hs.497741  [show with all ESTs]
    Unigene Representative Sequence: NM_016343
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366955(uc001hkm.3) ENST00000464322 ENST00000495259 ENST00000467765
    ENST00000469862

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CENPF
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate CENPF:
    hsa-miR-205 hsa-miR-520f hsa-miR-2115 hsa-miR-510
    SwitchGear 3'UTR luciferase reporter plasmid: CENPF 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CENPF (see all 4)
    OriGene shRNA RFP: CENPF
    OriGene siRNA: CENPF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CENPF
    Clone
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    GenScript: all cDNA clones in your preferred vector: CENPF (NM_016343)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CENPF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPF 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CENPF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CENPF

    Additional cDNA sequence: 

    AK307690.1 U19769.1 U25725.1 U30872.1 

    10 DOTS entries:

    DT.451965  DT.100647943  DT.95101953  DT.100029355  DT.100861068  DT.95101934  DT.95101938  DT.95101962 
    DT.95333967  DT.95101937 

    24/256 AceView cDNA sequences (see all 256):

    AU119246 BM480419 AI219225 BX415708 AI559904 AU118719 CA455130 CR597113 
    CB129229 BE046018 BQ424843 BU188761 AA633479 T89017 BU618793 AL134865 
    AI142604 CA748558 BU155312 CB145897 BE046913 U30872 NM_016343 BQ688528 

    GeneLoc Exon Structure


    Expression
    for CENPF gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CENPF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTAGGTATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CENPF expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyS-shaped BodyKidney Endothelial CellsEndothelium
    TestisTestis CordXY Germ CellsGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    Adult human kidney epithelial cells (Primary Cell)Kidney

    See CENPF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CENPF

    SOURCE GeneReport for Unigene cluster: Hs.497741
        SABiosciences Custom PCR Arrays for CENPF
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CENPF
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPF

    Orthologs
    for CENPF gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CENPF gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CENPF1 centromere protein F, 350/400kDa (mitosin) 55.51(n)
    40.72(a)    		   395357  NM_204645.2  NP_989976.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii cenpf1 centromere protein F, (mitosin) 45.26(n)
    31.67(a)    		   497403  XM_002665215.2  XP_002665261.2 
    honey bee
    (Apis mellifera)    		 Insecta --
    --
    		 --
    		 8(a)
    10(a)
    		 1 ↔ many
    possible ortholog
    		 GroupUn.9(154139-167900)
    Group8.17(54593-62455)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G643306
    AT1G053206
    (see all 4)    		 uncharacterized protein
    (see all 4)    		 14(a)
    12(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 1(23870905-23874198)
    1(1553603-1557733)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 retrotransposon protein, putative, unclassified, e...
    		 12(a)
    		 possible ortholog
    		 4(31002238-31010796)


    ENSEMBL Gene Tree for CENPF (if available)
    TreeFam Gene Tree for CENPF (if available) 

    Paralogs
    for CENPF gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CENPF gene
    GOLGA42  GCC22  CEP2502  AKAP92  PCNT2  LOC7287632  CROCC2  EEA12  
    NUMA12  TRIP112  CNTRL2  GOLGB12  

    CENPF for paralogs           About GeneDecksing



    Genomic Variants
    for CENPF gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1258 NCBI SNPs in CENPF are shown (see all 1258)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1451391051,2
    		--214774717(+) GTAGAA/CAAGAT 1 -- us2k10--------
    rs1406078761,2
    		C,--214774793(+) AGTAG-/ACT   
       GGCTA    ACTGA     		1 -- us2k10--------
    rs177926741,2
    		C,F,H,--214774867(+) TCTGTC/TTTTGG 1 -- us2k110Minor allele frequency- T:0.05NA NS EA WA 918
    rs1473903391,2
    		C,--214774912(+) CAACC-/GGGGGG 1 -- us2k10--------
    rs1490829591,2
    		--214774975(+) CAGGAA/GTTACT 1 -- us2k10--------
    rs1835269751,2
    		--214775039(+) TGTTCA/GTTGTA 1 -- us2k10--------
    rs1447329431,2
    		--214775097(+) ATCTGA/CTGAAG 1 -- us2k10--------
    rs763389421,2
    		F,--214775116(+) AATGAA/GTAGTA 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs615339241,2
    		--214775172(+) GTCTTA/TCTAGC 1 -- us2k10--------
    rs9984521,2
    		C,F,O,A,H,--214775195(+) CTTAAA/GCAGCC 1 -- us2k1 tfbs316Minor allele frequency- G:0.18NA PA NS EA WA CSA 993

    HapMap Linkage Disequilibrium report for CENPF (214776532 - 214837931 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for CENPF
         3 CNVs: 22966 65838 71234
         1 Indel: 44506

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    Disorders / Diseases
    for CENPF gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CENPF for disorders           About GeneDecksing

    OMIM gene information: 600236    OMIM disorders: --

    20/25 diseases for CENPF (see all 25):    About MalaCards
    graft versus host disease    dna topoisomerase i    non-hodgkin lymphoma    esophageal squamous cell carcinoma
    squamous cell carcinoma    hodgkin's lymphoma    diffuse astrocytoma    fanconi's anemia
    kaposi's sarcoma    astrocytoma    retinoblastoma    breast cancer
    anemia    sarcoma    gingivitis    esophagitis
    nasopharyngitis    carcinoma    meningioma    breast carcinoma

    9 Novoseek disease relationships for CENPF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 22.4 3 11556747 (3)
    tumors 20.1 26 19102762 (4), 11303627 (3), 12507285 (2), 15927522 (2) (see all 8)
    glioblastoma 19.1 1 12937144 (1)
    retinoblastoma 18 4 7651420 (1), 11814677 (1)
    cancer 6.67 9 15927522 (3), 9156273 (1), 17431110 (1), 11303627 (1)
    carcinoma squamous cell 5.67 6 14720137 (2), 11303627 (2), 11092977 (1)
    leukemia 0 1 15032718 (1)
    breast cancer 0 11 17205517 (4), 9407959 (3), 19102762 (2)
    metastasis 0 1 11303627 (1)

    Human Genome Epidemiology (HuGE) Navigator: CENPF (1 document)

    Export disorders for CENPF gene to outside databases

    Publications
    for CENPF gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CENPF gene, integrated from 9 sources (see all 109):
    (articles sorted by number of sources associating them with CENPF)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis. (PubMed id 7542657)1, 2, 9 Liao H.... Yen T.J. (1995)
    2. Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. (PubMed id 10852915)1, 2, 9 Ashar H.R.... Kirschmeier P. (2000)
    3. Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. (PubMed id 12974617)1, 2, 9 Yang Z.Y.... Zhu X.L. (2003)
    4. Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression. (PubMed id 7651420)1, 2, 9 Zhu X.... Lee W.-H. (1995)
    5. Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24-->q25 and 1q32-->q41, respectively, by fluorescence in situ hybridization. (PubMed id 7851898)1, 3, 9 Testa J.R....Yen T.J. (1994)
    6. Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes. (PubMed id 17600710)1, 2 Vergnolle M.A.S. and Taylor S.S. (2007)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. (PubMed id 9763420)1, 2 Chan G.K.T.... Yen T.J. (1998)
    10. The C-terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization. (PubMed id 7642639)1, 2 Zhu X.... Lee W.-H. (1995)

    External Searches for CENPF gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing CENPF gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1063 HGNC: 1857 AceView: CENPF Ensembl:ENSG00000117724 euGenes: HUgn1063
    ECgene: CENPF H-InvDB: CENPF

    Other Databases showing CENPF gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CENPF gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CENPF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CENPF Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for CENPF gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CENPF gene:
    Search GeneIP for patents involving CENPF

    GeneCards and IP:
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