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CENPF Gene

protein-coding   GIFtS: 61
GCID: GC01P214776

Centromere Protein F, 350/400kDa

(Previous names: centromere protein F, 350/400kDa (mitosin))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centromere Protein F, 350/400kDa1 2     Cell-Cycle-Dependent 350K Nuclear Protein2
Centromere Protein F, 350/400kDa (Mitosin)1 2     CENP-F Kinetochore Protein2
mitosin1 2     Centromere Protein F2
Kinetochore Protein CENPF2 3     Centromere Protein F, 350/400ka (Mitosin)2
AH Antigen2 3     hcp-12
CENF2     CENP-F3
PRO17792     Mitosin3

External Ids:    HGNC: 18571   Entrez Gene: 10632   Ensembl: ENSG000001177247   OMIM: 6002365   UniProtKB: P494543   

Export aliases for CENPF gene to outside databases

Previous GC identifers: GC01P213428 GC01P210596 GC01P211392 GC01P211833 GC01P211165 GC01P212843 GC01P185450


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CENPF Gene:
This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of
the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and
maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular
bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization
of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form
either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or
graft versus host disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for CENPF Gene:
CENPF (centromere protein F, 350/400kDa) is a protein-coding gene. Diseases associated with CENPF include graft versus host disease, and diffuse astrocytoma. GO annotations related to this gene include protein homodimerization activity and transcription factor binding.

UniProtKB/Swiss-Prot: CENPF_HUMAN, P49454
Function: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore
localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link
between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a
potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity
of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal
embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing
neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in
the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role
regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell
regulation of T-cell immunity against chlamydia

Gene Wiki entry for CENPF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CENPF gene promoter:
         HOXA9   HOXA9B   AhR   HTF   Pax-2   Pax-2a   Meis-1b   CBF-A   Meis-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCENPF promoter sequence
   Search Chromatin IP Primers for CENPF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CENPF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

CENPF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPF gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P214776:  view genomic region     (about GC identifiers)

Start:
214,776,532 bp from pter      End:
214,837,931 bp from pter
Size:
61,400 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CENPF_HUMAN, P49454 (See protein sequence)
Recommended Name: Centromere protein F precursor  
Size: 3210 amino acids; 367764 Da
Subunit: Interacts with and STX4 (via C-terminus) (By similarity). Interacts (via N-terminus) with RBL1, RBL2 and
SNAP25 (By similarity). Self-associates. Interacts with CENP-E and BUBR1 (via C-terminus). Interacts (via
C-terminus) with NDE1, NDEL1 and RB1
Developmental stage: Gradually accumulates during the cell cycle, reaching peak levels in G2 and M phase, and is
rapidly degraded upon completion of mitosis
Secondary accessions: Q13171 Q13246 Q5VVM7

Explore the universe of human proteins at neXtProt for CENPF: NX_P49454

Explore proteomics data for CENPF at MOPED

Post-translational modifications: 

  • Hyperphosphorylated during mitosis1
  • Ubiquitination2 at Lys19, Lys223, Lys293, Lys314, Lys356, Lys457, Lys513, Lys527, Lys555, Lys697,
                                 Lys768, Lys770, Lys823, Lys956, Lys1022, Lys1088, Lys1334, Lys1341, Lys1410, Lys1906 (see all 22)
  • Modification sites at PhosphoSitePlus

  • See CENPF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057427.3  
    ENSEMBL proteins: 
     ENSP00000355922  
    Reactome Protein details: P49454

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    Cloud-Clone Corp. CLIAs for CENPF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR019513 Centromere_CenpF_leu-rich_rpt
     IPR018463 Centromere_CenpF_N
     IPR018302 CenpF/LEK1_Rb-prot-bd

    Graphical View of Domain Structure for InterPro Entry P49454

    ProtoNet protein and cluster: P49454

    UniProtKB/Swiss-Prot: CENPF_HUMAN, P49454
    Similarity: Belongs to the centromere protein F family


    CENPF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPF_HUMAN, P49454
    Function: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore
    localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link
    between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a
    potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity
    of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal
    embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing
    neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in
    the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role
    regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell
    regulation of T-cell immunity against chlamydia

         Genatlas biochemistry entry for CENPF:
    centromere protein F,component of the outer kinetochore plate

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding NAS9891037
    GO:0005515protein binding IPI17043677
    GO:0008022protein C-terminus binding IPI7642639
    GO:0008134transcription factor binding IPI15677469
    GO:0042803protein homodimerization activity IPI7642639
         
    CENPF for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CENPF:
     Decreased viability with pacli 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cenpf):
     cardiovascular system  cellular  growth/size/body  mortality/aging  muscle 

    CENPF for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CENPF
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CENPF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CENPF

    miRNA
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    miRTarBase miRNAs that target CENPF:
    hsa-mir-877-5p (MIRT037353), hsa-mir-215-5p (MIRT024521), hsa-mir-122-5p (MIRT023287), hsa-mir-93-3p (MIRT038774), hsa-mir-375 (MIRT019840), hsa-mir-373-3p (MIRT002525), hsa-mir-192-5p (MIRT026480), hsa-mir-1226-3p (MIRT036512), hsa-mir-16-5p (MIRT031672), hsa-mir-1 (MIRT023780)

    Block miRNA regulation of human, mouse, rat CENPF using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate CENPF:
    hsa-miR-205 hsa-miR-520f hsa-miR-2115 hsa-miR-510
    SwitchGear 3'UTR luciferase reporter plasmidCENPF 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CENPF

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPF

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CENPF_HUMAN, P49454: Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore.
    Cytoplasm, cytoskeleton, spindle. Note=Relocalizes to the kinetochore/centromere (coronal surface of the outer
    plate) and the spindle during mitosis. Observed in nucleus during interphase but not in the nucleolus. At
    metaphase becomes localized to areas including kinetochore and mitotic apparatus as well as cytoplasm. By
    telophase, is concentrated within the intracellular bridge at either side of the mid-body
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA11084331
    GO:0000776kinetochore IDA17363900
    GO:0000785colocalizes with chromatin NAS9891037
    GO:0000922spindle pole IDA7542657
    GO:0000940condensed chromosome outer kinetochore TAS12974617

    CENPF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CENPF About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Regulation of PLK1 Activity at G2/M Transition
    G2/M Transition0.70
    Polo-like kinase mediated events0.00
    Mitotic G2-G2/M phases0.69
    4Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    5Gastric cancer network 1
    Gastric cancer network 1

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for CENPF
        Gastric cancer network 1
    FOXM1 transcription factor network

    4 Reactome Pathways for CENPF
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    Polo-like kinase mediated events



    CENPF for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CENPF
    Interactions:

        GeneGlobe Interaction Network for CENPF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CENPF (P494541, 2, 3 ENSP000003559224) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDEL1Q9GZM81, 3, ENSP000003339824EBI-968343,EBI-928842 I2D: score=2 STRING: ENSP00000333982
    NUP133Q8WUM01, 2, 3, ENSP000002613964EBI-968343,EBI-295695 MINT-4788132 MINT-4788150 I2D: score=2 STRING: ENSP00000261396
    CENPEQ022243, ENSP000002651484I2D: score=2 STRING: ENSP00000265148
    FNTAP493543, ENSP000003034234I2D: score=2 STRING: ENSP00000303423
    FNTBP493563, ENSP000002461664I2D: score=2 STRING: ENSP00000246166
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000085mitotic G2 phase IMP12154071
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000087mitotic M phase IMP12154071
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication IEA--

    CENPF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CENPF

    4 Novoseek inferred chemical compound relationships for CENPF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lonafarnib 73.8 2 17431110 (2)
    leucine 21.4 2 15677469 (2)
    paclitaxel 9.8 2 12467231 (1)
    tyrosine 0 2 11953011 (1), 14724156 (1)



    CENPF for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CENPF gene: 
    NM_016343.3  

    Unigene Cluster for CENPF:

    Centromere protein F, 350/400kDa
    Hs.497741  [show with all ESTs]
    Unigene Representative Sequence: NM_016343
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464322 ENST00000366955(uc001hkm.3) ENST00000495259 ENST00000467765
    ENST00000469862
    miRNA
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    hsa-miR-205 hsa-miR-520f hsa-miR-2115 hsa-miR-510
    SwitchGear 3'UTR luciferase reporter plasmidCENPF 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CENPF
      QuantiFast Probe-based Assays in human, mouse, rat CENPF

    Additional mRNA sequence: 

    AK307690.1 U19769.1 U25725.1 U30872.1 

    10 DOTS entries:

    DT.451965  DT.100647943  DT.95101953  DT.100029355  DT.100861068  DT.95101934  DT.95101938  DT.95101962 
    DT.95333967  DT.95101937 

    Selected AceView cDNA sequences (see all 256):

    R58608 AA535948 CB108852 BU618793 BI871558 BU155312 BM677311 AU132621 
    BE046913 BU521335 U30872 BG259797 T89017 BQ222419 CA748558 BQ688528 
    AI219225 BQ222736 AA569029 BQ424843 AI673331 BU188761 BE046018 AL134865 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CENPF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAGGTATT
    CENPF Expression
    About this image


    CENPF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Gonad
             XY Germ Cells Testis Cord
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    CENPF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CENPF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497741
        Custom PCR Arrays for CENPF
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CENPF gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenpf1 , 5 centromere protein F1, 5 75.67(n)1
    65.48(a)1
      1 (95.03 cM)5
    1080001  NM_001081363.21  NP_001074832.21 
     1896405995 
    chicken
    (Gallus gallus)
    Aves CENPF1 centromere protein F, 350/400kDa (mitosin) 59.13(n)
    44.33(a)
      395357  NM_204645.2  NP_989976.2 
    lizard
    (Anolis carolinensis)
    Reptilia CENPF6
    centromere protein F, 350/400kDa
    40(a)
    1 ↔ 1
    1(240010792-240052996)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cenpf1 centromere protein F, 350/400kDa 53.33(n)
    42.05(a)
      100127686  XM_002934692.2  XP_002934738.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cenpf6
    centromere protein F, (mitosin)
    29(a)
    1 ↔ 1
    17(32927923-32948802) ENSDARG00000055133


    ENSEMBL Gene Tree for CENPF (if available)
    TreeFam Gene Tree for CENPF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CENPF (see all 1609)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1451391051,2
    --214774717(+) GTAGAA/CAAGAT 1 -- us2k10--------
    rs1406078761,2
    C--214774793(+) AGTAG-/ACT   
       GGCTA
    ACTGA
    1 -- us2k10--------
    rs177926741,2
    C,F,H--214774867(+) TCTGTC/TTTTGG 1 -- us2k110Minor allele frequency- T:0.05NA NS EA WA 918
    rs1473903391,2
    C--214774912(+) CAACC-/GGGGGG 1 -- us2k10--------
    rs1490829591,2
    C--214774975(+) CAGGAA/GTTACT 1 -- us2k10--------
    rs1835269751,2
    --214775039(+) TGTTCA/GTTGTA 1 -- us2k10--------
    rs1447329431,2
    --214775097(+) ATCTGA/CTGAAG 1 -- us2k10--------
    rs763389421,2
    F--214775116(+) AATGAA/GTAGTA 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs615339241,2
    --214775172(+) GTCTTA/TCTAGC 1 -- us2k10--------
    rs9984521,2
    C,F,O,A,H--214775195(+) CTTAAA/GCAGCC 1 -- us2k1 tfbs316Minor allele frequency- G:0.18NA PA NS EA WA CSA 993

    HapMap Linkage Disequilibrium report for CENPF (214776532 - 214837931 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CENPF:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722628CNV Deletion23290073
    esv2145066CNV Deletion18987734
    nsv436780CNV Insertion17901297
    esv1007536CNV Insertion20482838
    nsv873165CNV Loss21882294
    nsv160230CNV Loss16902084
    esv29119CNV Loss19812545
    esv27146CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CENPF
    DNA2.0 Custom Variant and Variant Library Synthesis for CENPF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600236    OMIM disorders: --

    Selected diseases for CENPF (see all 24):    
    About MalaCards
    graft versus host disease    diffuse astrocytoma    chronic graft versus host disease    astrocytoma
    retinoblastoma    fanconi's anemia    gingivitis    kaposi's sarcoma
    esophageal squamous cell carcinoma    non-hodgkin lymphoma    hodgkin's lymphoma    nasopharyngitis
    meningioma    squamous cell carcinoma    sarcoma    esophagitis
    schizophrenia    chronic lymphocytic leukemia    breast cancer    melanoma


    CENPF for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for CENPF gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 22.4 3 11556747 (3)
    tumors 20.1 26 19102762 (4), 11303627 (3), 12507285 (2), 15927522 (2) (see all 8)
    glioblastoma 19.1 1 12937144 (1)
    retinoblastoma 18 4 7651420 (1), 11814677 (1)
    cancer 6.67 9 15927522 (3), 9156273 (1), 17431110 (1), 11303627 (1)
    carcinoma squamous cell 5.67 6 14720137 (2), 11303627 (2), 11092977 (1)
    leukemia 0 1 15032718 (1)
    breast cancer 0 11 17205517 (4), 9407959 (3), 19102762 (2)
    metastasis 0 1 11303627 (1)

    Genetic Association Database (GAD): CENPF
    Human Genome Epidemiology (HuGE) Navigator: CENPF (1 document)

    Export disorders for CENPF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CENPF gene, integrated from 10 sources (see all 117):
    (articles sorted by number of sources associating them with CENPF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis. (PubMed id 7542657)1, 2, 9 Liao H.... Yen T.J. (J. Cell Biol. 1995)
    2. Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. (PubMed id 10852915)1, 2, 9 Ashar H.R.... Kirschmeier P. (J. Biol. Chem. 2000)
    3. Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. (PubMed id 12974617)1, 2, 9 Yang Z.Y.... Zhu X.L. (Cell Res. 2003)
    4. Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression. (PubMed id 7651420)1, 2, 9 Zhu X.... Lee W.-H. (Mol. Cell. Biol. 1995)
    5. Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24--&gt;q25 and 1q32--&gt;q41, respectively, by fluorescence in situ hybridization. (PubMed id 7851898)1, 3, 9 Testa J.R....Yen T.J. (Genomics 1994)
    6. Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial. (PubMed id 21659360)1, 4 Wade R....Houlston R.S. (Haematologica 2011)
    7. Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study. (PubMed id 19008095)1, 4 Brendle A....FAPrsti A. (Eur. J. Cancer 2009)
    8. Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes. (PubMed id 17600710)1, 2 Vergnolle M.A.S. and Taylor S.S. (Curr. Biol. 2007)
    9. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1063 HGNC: 1857 AceView: CENPF Ensembl:ENSG00000117724 euGenes: HUgn1063
    ECgene: CENPF H-InvDB: CENPF

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CENPF Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CENPF Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CENPF gene:
    Search GeneIP for patents involving CENPF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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