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Aliases for CENPF Gene

Aliases for CENPF Gene

  • Centromere Protein F, 350/400kDa 2 3
  • Mitosin 2 3 4
  • Centromere Protein F, 350/400kDa (Mitosin) 2 3
  • Kinetochore Protein CENPF 3 4
  • AH Antigen 3 4
  • Cell-Cycle-Dependent 350K Nuclear Protein 3
  • Centromere Protein F, 350/400ka (Mitosin) 3
  • CENP-F Kinetochore Protein 3
  • Centromere Protein F 3
  • PRO1779 3
  • CENP-F 4
  • Hcp-1 3
  • CENF 3

External Ids for CENPF Gene

Previous GeneCards Identifiers for CENPF Gene

  • GC01P213428
  • GC01P210596
  • GC01P211392
  • GC01P211833
  • GC01P211165
  • GC01P212843
  • GC01P214776
  • GC01P185450

Summaries for CENPF Gene

Entrez Gene Summary for CENPF Gene

  • This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for CENPF Gene

CENPF (Centromere Protein F, 350/400kDa) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein homodimerization activity and transcription factor binding.

UniProtKB/Swiss-Prot for CENPF Gene

  • Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia.

Gene Wiki entry for CENPF Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPF Gene

Genomics for CENPF Gene

Regulatory Elements for CENPF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CENPF Gene

Start:
214,603,189 bp from pter
End:
214,664,588 bp from pter
Size:
61,400 bases
Orientation:
Plus strand

Genomic View for CENPF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CENPF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPF Gene

Proteins for CENPF Gene

  • Protein details for CENPF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49454-CENPF_HUMAN
    Recommended name:
    Centromere protein F
    Protein Accession:
    P49454
    Secondary Accessions:
    • Q13171
    • Q13246
    • Q5VVM7

    Protein attributes for CENPF Gene

    Size:
    3210 amino acids
    Molecular mass:
    367764 Da
    Quaternary structure:
    • Interacts with and STX4 (via C-terminus) (By similarity). Interacts (via N-terminus) with RBL1, RBL2 and SNAP25 (By similarity). Self-associates. Interacts with CENP-E and BUBR1 (via C-terminus). Interacts (via C-terminus) with NDE1, NDEL1 and RB1.

neXtProt entry for CENPF Gene

Proteomics data for CENPF Gene at MOPED

Post-translational modifications for CENPF Gene

  • Hyperphosphorylated during mitosis
  • Ubiquitination at Lys19, Lys223, Lys293, Lys314, Lys356, Lys457, Lys513, Lys527, Lys555, Lys697, Lys768, Lys770, Lys823, Lys956, Lys1022, Lys1088, Lys1334, Lys1341, Lys1410, Lys1906, Lys2132, and Lys2940
  • Modification sites at PhosphoSitePlus

Other Protein References for CENPF Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CENPF Gene

Domains for CENPF Gene

Protein Domains for CENPF Gene

Suggested Antigen Peptide Sequences for CENPF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49454

UniProtKB/Swiss-Prot:

CENPF_HUMAN :
  • P49454
Family:
  • Belongs to the centromere protein F family.
genes like me logo Genes that share domains with CENPF: view

No data available for Gene Families for CENPF Gene

Function for CENPF Gene

Molecular function for CENPF Gene

GENATLAS Biochemistry: centromere protein F,component of the outer kinetochore plate
UniProtKB/Swiss-Prot Function: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia.

Gene Ontology (GO) - Molecular Function for CENPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding NAS 9891037
GO:0005515 protein binding IPI 17043677
GO:0008022 protein C-terminus binding IPI 7642639
GO:0008134 transcription factor binding IPI 15677469
GO:0042803 protein homodimerization activity IPI 7642639
genes like me logo Genes that share ontologies with CENPF: view
genes like me logo Genes that share phenotypes with CENPF: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CENPF Gene

Localization for CENPF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPF Gene

Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Relocalizes to the kinetochore/centromere (coronal surface of the outer plate) and the spindle during mitosis. Observed in nucleus during interphase but not in the nucleolus. At metaphase becomes localized to areas including kinetochore and mitotic apparatus as well as cytoplasm. By telophase, is concentrated within the intracellular bridge at either side of the mid-body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPF Gene COMPARTMENTS Subcellular localization image for CENPF gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for CENPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 11084331
GO:0000776 kinetochore IDA 17363900
GO:0000785 colocalizes_with chromatin NAS 9891037
GO:0000922 spindle pole IDA 7542657
GO:0000940 condensed chromosome outer kinetochore TAS 12974617
genes like me logo Genes that share ontologies with CENPF: view

Pathways for CENPF Gene

genes like me logo Genes that share pathways with CENPF: view

Pathways by source for CENPF Gene

Gene Ontology (GO) - Biological Process for CENPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0007059 chromosome segregation NAS 7542657
GO:0007067 mitotic nuclear division IEA --
GO:0007094 mitotic spindle assembly checkpoint NAS 12974617
genes like me logo Genes that share ontologies with CENPF: view

Compounds for CENPF Gene

(4) Novoseek inferred chemical compound relationships for CENPF Gene

Compound -log(P) Hits PubMed IDs
lonafarnib 73.8 2
leucine 21.4 2
paclitaxel 9.8 1
tyrosine 0 2
genes like me logo Genes that share compounds with CENPF: view

Transcripts for CENPF Gene

Unigene Clusters for CENPF Gene

Centromere protein F, 350/400kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CENPF

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CENPF

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CENPF Gene

No ASD Table

Relevant External Links for CENPF Gene

GeneLoc Exon Structure for
CENPF
ECgene alternative splicing isoforms for
CENPF

Expression for CENPF Gene

mRNA expression in normal human tissues for CENPF Gene

mRNA differential expression in normal tissues according to GTEx for CENPF Gene

This gene is overexpressed in Testis (4.8) and Esophagus - Mucosa (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPF Gene

SOURCE GeneReport for Unigene cluster for CENPF Gene Hs.497741

genes like me logo Genes that share expressions with CENPF: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CENPF Gene

Orthologs for CENPF Gene

This gene was present in the common ancestor of animals.

Orthologs for CENPF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPF 35
  • 99.28 (n)
  • 98.78 (a)
CENPF 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CENPF 35
  • 84.66 (n)
  • 78.63 (a)
CENPF 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
CENPF 35
  • 83.79 (n)
  • 76.66 (a)
mouse
(Mus musculus)
Mammalia Cenpf 35
  • 75.67 (n)
  • 65.48 (a)
Cenpf 16
Cenpf 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPF 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPF 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpf 35
  • 77.45 (n)
  • 67.93 (a)
chicken
(Gallus gallus)
Aves CENPF 35
  • 59.13 (n)
  • 44.33 (a)
CENPF 36
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPF 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpf 35
  • 53.33 (n)
  • 42.05 (a)
zebrafish
(Danio rerio)
Actinopterygii cenpf 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C02F12.7 37
  • 21 (a)
Species with no ortholog for CENPF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CENPF Gene

ENSEMBL:
Gene Tree for CENPF (if available)
TreeFam:
Gene Tree for CENPF (if available)

Paralogs for CENPF Gene

No data available for Paralogs for CENPF Gene

Variants for CENPF Gene

Sequence variations from dbSNP and Humsavar for CENPF Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7289 - 214,663,767(-) CTGCC(C/G)TTGGA reference, missense
rs14284 -- 214,663,819(+) ACCCC(C/T)GGGAG utr-variant-3-prime
rs179813 -- 214,653,719(-) TGTAC(C/T)TAATT intron-variant
rs335522 -- 214,653,645(-) TATTT(G/T)CTGGA intron-variant
rs335523 -- 214,653,021(-) CCATT(C/T)GAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPF Gene

Variant ID Type Subtype PubMed ID
esv29119 CNV Loss 19812545
esv27146 CNV Gain+Loss 19812545
esv2145066 CNV Deletion 18987734
esv2722628 CNV Deletion 23290073
nsv160230 CNV Loss 16902084
esv1007536 CNV Insertion 20482838
nsv873165 CNV Loss 21882294
nsv436780 CNV Insertion 17901297

Relevant External Links for CENPF Gene

HapMap Linkage Disequilibrium report
CENPF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPF Gene

Disorders for CENPF Gene

(9) Novoseek inferred disease relationships for CENPF Gene

Disease -log(P) Hits PubMed IDs
astrocytoma 22.4 3
tumors 20.1 15
glioblastoma 19.1 1
retinoblastoma 18 2
cancer 6.67 6

Relevant External Links for CENPF

Genetic Association Database (GAD)
CENPF
Human Genome Epidemiology (HuGE) Navigator
CENPF
genes like me logo Genes that share disorders with CENPF: view

No data available for UniProtKB/Swiss-Prot for CENPF Gene

Publications for CENPF Gene

  1. CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis. (PMID: 7542657) Liao H. … Yen T.J. (J. Cell Biol. 1995) 3 4 23
  2. Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression. (PMID: 7651420) Zhu X. … Lee W.-H. (Mol. Cell. Biol. 1995) 3 4 23
  3. Chromosomal localization of the genes encoding the kinetochore proteins CENPE and CENPF to human chromosomes 4q24-->q25 and 1q32-->q41, respectively, by fluorescence in situ hybridization. (PMID: 7851898) Testa J.R. … Yen T.J. (Genomics 1994) 2 3 23
  4. Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. (PMID: 10852915) Ashar H.R. … Kirschmeier P. (J. Biol. Chem. 2000) 3 4 23
  5. Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. (PMID: 12974617) Yang Z.Y. … Zhu X.L. (Cell Res. 2003) 3 4 23

Products for CENPF Gene

Sources for CENPF Gene

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